TY  - JOUR
AU  - Radovanović, Ana M.
AU  - Cupara, Snežana
AU  - Popović, Suzana L. J.
AU  - Tomović, Marina T.
AU  - Slavkovska, Violeta
AU  - Janković, Slobodan
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1869
AB  - Potentilla reptans L. belongs to the least studied of the plants from Rosaceae family, Potentilla genus. There are no data on cytotoxicity of P. reptans extracts, though traditionaly it was used as anti-inflammatory and antiinfective. The aim of these studies was to investigate potential antitumor activity of aqueous extracts (rhizome and aerial parts) of P. reptans on 4T1 mouse breast cancer cell line._Aqueous extracts of rhizome and aerial parts of P. reptans were tested for cytotoxicity by the MTT colorimetric assay on 4T1 cancer cell line in concentration range 100-800 mu g/mL. Aqueous extracts of P. reptans rhizome and aerial parts show concentration dependent cytotoxic effect in the range of tested concentrations. IC50 value of P. reptans rhizome extract was 280.51 +/- 1.16 mu g/mL. IC50 value of P. reptans aerial parts extract was 310.79 +/- 1.22 mu g/mL. The significant difference in cytotoxicity among tested concentrations was observed. Aqueous extracts of P. mptans rhizome and aerial parts demonstrated weak cytotoxic activity on 4T1 mouse breast cancer cell line, which is in correlation with current cytotoxicity data for aqueous herbal extracts. Rhizome extract of P. reptans has slightly higher antitumor activity than aerial parts extract. The results represent the first report on cytotoxicity for this plant and further research on human cell lines is indicated.
PB  - Polskie Towarzystwo Farmaceutyczne, Warsaw
T2  - Acta Poloniae Pharmaceutica - Drug Research
T1  - Cytotoxic effect of Potentilla reptans L. rhizome and aerial part extracts
VL  - 70
IS  - 5
SP  - 851
EP  - 854
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1869
ER  - 

@article{
author = "Radovanović, Ana M. and Cupara, Snežana and Popović, Suzana L. J. and Tomović, Marina T. and Slavkovska, Violeta and Janković, Slobodan",
year = "2013",
abstract = "Potentilla reptans L. belongs to the least studied of the plants from Rosaceae family, Potentilla genus. There are no data on cytotoxicity of P. reptans extracts, though traditionaly it was used as anti-inflammatory and antiinfective. The aim of these studies was to investigate potential antitumor activity of aqueous extracts (rhizome and aerial parts) of P. reptans on 4T1 mouse breast cancer cell line._Aqueous extracts of rhizome and aerial parts of P. reptans were tested for cytotoxicity by the MTT colorimetric assay on 4T1 cancer cell line in concentration range 100-800 mu g/mL. Aqueous extracts of P. reptans rhizome and aerial parts show concentration dependent cytotoxic effect in the range of tested concentrations. IC50 value of P. reptans rhizome extract was 280.51 +/- 1.16 mu g/mL. IC50 value of P. reptans aerial parts extract was 310.79 +/- 1.22 mu g/mL. The significant difference in cytotoxicity among tested concentrations was observed. Aqueous extracts of P. mptans rhizome and aerial parts demonstrated weak cytotoxic activity on 4T1 mouse breast cancer cell line, which is in correlation with current cytotoxicity data for aqueous herbal extracts. Rhizome extract of P. reptans has slightly higher antitumor activity than aerial parts extract. The results represent the first report on cytotoxicity for this plant and further research on human cell lines is indicated.",
publisher = "Polskie Towarzystwo Farmaceutyczne, Warsaw",
journal = "Acta Poloniae Pharmaceutica - Drug Research",
title = "Cytotoxic effect of Potentilla reptans L. rhizome and aerial part extracts",
volume = "70",
number = "5",
pages = "851-854",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1869"
}

Radovanović, A. M., Cupara, S., Popović, S. L. J., Tomović, M. T., Slavkovska, V.,& Janković, S.. (2013). Cytotoxic effect of Potentilla reptans L. rhizome and aerial part extracts. in Acta Poloniae Pharmaceutica - Drug Research
Polskie Towarzystwo Farmaceutyczne, Warsaw., 70(5), 851-854.
https://hdl.handle.net/21.15107/rcub_farfar_1869

Radovanović AM, Cupara S, Popović SLJ, Tomović MT, Slavkovska V, Janković S. Cytotoxic effect of Potentilla reptans L. rhizome and aerial part extracts. in Acta Poloniae Pharmaceutica - Drug Research. 2013;70(5):851-854.
https://hdl.handle.net/21.15107/rcub_farfar_1869 .

Radovanović, Ana M., Cupara, Snežana, Popović, Suzana L. J., Tomović, Marina T., Slavkovska, Violeta, Janković, Slobodan, "Cytotoxic effect of Potentilla reptans L. rhizome and aerial part extracts" in Acta Poloniae Pharmaceutica - Drug Research, 70, no. 5 (2013):851-854,
https://hdl.handle.net/21.15107/rcub_farfar_1869 .