TY  - JOUR
AU  - Kosec, Duško
AU  - Vidić-Danković, Biljana
AU  - Isaković, K
AU  - Leposavić, Gordana
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/593
AB  - Experimental autoimmune myasthenia gravis (EAMG) was induced in female AO rats, by a single immunization with Torpedo acetylcholine receptor (AChR). Animals injected with saline served as controls. The study showed substantial changes in EAMG rats in the thymopoiesis, causing an increase in the relative proportion of mature CD8+ and, particularly, CD4+ (possibly autoreactive) single positive (SP) cells expressing TCR alpha beta at high level (TCR alpha beta(high)), as well as in that of mature double negative (DN) TCR alpha beta(high) cells, which are believed to be the immunoregulatory cells that augment autoantibody (autoAb) production. These results indicate that an augmented production of autoreactive CD4+ cells, on one side, and an increase of the immunoregulatory T cells that augment autoAb production, on the other side (reflecting, most likely, an increased entry of activated autoreactive CD4+ T cells from the periphery into the thymus), may have a significant role in the sustention of immune response in EAMG, and may suggest a putative mechanism underlying the sustention of autoimmune response in acquired MG.
PB  - Taylor & Francis Ltd, Abingdon
T2  - International Journal of Neuroscience
T1  - Alterations in the thymopoiesis in experimental autoimmune myasthenia gravis
VL  - 115
IS  - 4
SP  - 461
EP  - 477
DO  - 10.1080/00207450590522464
ER  - 

@article{
author = "Kosec, Duško and Vidić-Danković, Biljana and Isaković, K and Leposavić, Gordana",
year = "2005",
abstract = "Experimental autoimmune myasthenia gravis (EAMG) was induced in female AO rats, by a single immunization with Torpedo acetylcholine receptor (AChR). Animals injected with saline served as controls. The study showed substantial changes in EAMG rats in the thymopoiesis, causing an increase in the relative proportion of mature CD8+ and, particularly, CD4+ (possibly autoreactive) single positive (SP) cells expressing TCR alpha beta at high level (TCR alpha beta(high)), as well as in that of mature double negative (DN) TCR alpha beta(high) cells, which are believed to be the immunoregulatory cells that augment autoantibody (autoAb) production. These results indicate that an augmented production of autoreactive CD4+ cells, on one side, and an increase of the immunoregulatory T cells that augment autoAb production, on the other side (reflecting, most likely, an increased entry of activated autoreactive CD4+ T cells from the periphery into the thymus), may have a significant role in the sustention of immune response in EAMG, and may suggest a putative mechanism underlying the sustention of autoimmune response in acquired MG.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "International Journal of Neuroscience",
title = "Alterations in the thymopoiesis in experimental autoimmune myasthenia gravis",
volume = "115",
number = "4",
pages = "461-477",
doi = "10.1080/00207450590522464"
}

Kosec, D., Vidić-Danković, B., Isaković, K.,& Leposavić, G.. (2005). Alterations in the thymopoiesis in experimental autoimmune myasthenia gravis. in International Journal of Neuroscience
Taylor & Francis Ltd, Abingdon., 115(4), 461-477.
https://doi.org/10.1080/00207450590522464

Kosec D, Vidić-Danković B, Isaković K, Leposavić G. Alterations in the thymopoiesis in experimental autoimmune myasthenia gravis. in International Journal of Neuroscience. 2005;115(4):461-477.
doi:10.1080/00207450590522464 .

Kosec, Duško, Vidić-Danković, Biljana, Isaković, K, Leposavić, Gordana, "Alterations in the thymopoiesis in experimental autoimmune myasthenia gravis" in International Journal of Neuroscience, 115, no. 4 (2005):461-477,
https://doi.org/10.1080/00207450590522464 . .