TY  - JOUR
AU  - Todorović, Tatjana
AU  - Vujanović, Dragana
AU  - Dozić, Ivan
AU  - Petković-Ćurčin, Aleksandra
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1087
AB  - Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.
PB  - John Libbey Eurotext Ltd, Montrouge
T2  - Magnesium Research
T1  - Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication
VL  - 21
IS  - 1
SP  - 43
EP  - 50
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1087
ER  - 

@article{
author = "Todorović, Tatjana and Vujanović, Dragana and Dozić, Ivan and Petković-Ćurčin, Aleksandra",
year = "2008",
abstract = "Lead manifests toxic effects in almost all organs and tissues, especially in: the nervous system, hematopoietic system, kidney and liver. This metal has a special affinity for deposition in hard tissue, i.e., bones and teeth. It is generally believed that the main mechanism of its toxicity relies on its interaction with bioelements, especially with Ca and Mg. This article analyses the influence of Pb poisoning on Ca and Mg content in hard tissues, (mandible, femur, teeth and skull) of female and young rats. Experiments were carried out on 60 female rats, AO breed, and on 80 of their young rats (offspring). Female rats were divided into three groups: the first one was a control group, the second one received 100 mg/kg Pb2+ kg b.wt. per day in drinking water, the third one received 30 mg/kg Pb2+ kg b.wt. per day in drinking water. Young rats (offspring) were divided into the same respective three groups. Lead, calcium and magnesium content in hard tissues (mandible, femur, teeth-incisors and skull) was determined by flame atomic absorption spectrophotometry in mineralized samples. There was a statistically significant Pb deposition in all analyzed female and young rat hard tissues. Ca and Mg contents were significantly reduced in all female and young rat hard tissues. These results show that Pb poisoning causes a significant reduction in Ca and Mg content in animal hard tissues, which is probably the consequence of competitive antagonism between Pb and Ca and Mg.",
publisher = "John Libbey Eurotext Ltd, Montrouge",
journal = "Magnesium Research",
title = "Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication",
volume = "21",
number = "1",
pages = "43-50",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1087"
}

Todorović, T., Vujanović, D., Dozić, I.,& Petković-Ćurčin, A.. (2008). Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication. in Magnesium Research
John Libbey Eurotext Ltd, Montrouge., 21(1), 43-50.
https://hdl.handle.net/21.15107/rcub_farfar_1087

Todorović T, Vujanović D, Dozić I, Petković-Ćurčin A. Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication. in Magnesium Research. 2008;21(1):43-50.
https://hdl.handle.net/21.15107/rcub_farfar_1087 .

Todorović, Tatjana, Vujanović, Dragana, Dozić, Ivan, Petković-Ćurčin, Aleksandra, "Calcium and magnesium content in hard tissues of rats under condition of subchronic lead intoxication" in Magnesium Research, 21, no. 1 (2008):43-50,
https://hdl.handle.net/21.15107/rcub_farfar_1087 .

TY  - JOUR
AU  - Todorović, Tatjana
AU  - Dožić, I.
AU  - Vujanović, Dragana
AU  - Pejović, J.
AU  - Marjanović, Marjan
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/661
AB  - In this paper, the influence of chronic lead intoxication on the activity of serum enzymes aspartate and alanine aminotransferases (AST and ALT) and alkaline phosphatase (ALP) was examined. The experiment was performed on 130 adult female DA rats and 80 young rats. Rats were treated by lead-acetate 100 and 30 mg Pb per kg body weight for 10, 20, 30, 40, 50 and 60 days. Young rats (offspring of studied female rats) were treated with lead only through the placenta and mother's milk. The activities of serum AST, ALT and ALP were determined spectrophotomerically by IFCC method. The activity of examined serum enzymes was significantly increased in conditions of chronic lead intoxication in female rats and their offspring in relation to the control group. The activity of serum AST, ALT and ALP was in a positive correlation with the time of intoxication. There were no significant differences between the activities of enzymes AST and ALT in the serum and the amount of lead. The activity of ALP was significantly higher in serum of rats treated with higher amounts of lead. Increased AST, ALT and ALP activity in serum is most likely the consequence of lead hepatotoxicity.
AB  - U ovom radu su prikazani rezultati ispitivanja uticaja hroničnog trovanja olovom na aktivnost enzima aspartat i alanin aminotransferaze (AST i ALT) kao i alkalne fosfataze (ALP) u krvnom serumu pacova. Eksperiment je izveden na 130 ženki pacova i njihovih 80 mladunaca. Ženke su tretirane olovo-acetatom oralno putem pijaće vode u dve doze-100 i 30 mg/kg TM dnevno u trajanju od 10,20,30, 40, 50 i 60 dana, dok su njihovi mladunci olovo primali samo preko placente i putem mleka. Nakon žrtvovanja, od životinja je uzimana krv i u krvnom serumu je spektrofotometrijski, na automatskom analizatoru Hitachi 911, određivana aktivnost enzima AST, ALT i ALR Dobijeni rezultati su ukazali da hronično trovanje olovom ima za posledicu značajno povećanje aktivnosti enzima AST, ALT i ALP u krvnom serumu ženki pacova, pri čemu se aktivnost navedenih enzima linearno povećavala sa povećanjem vremena intoksikacije. Nisu zapažene značajne razlike u aktivnosti enzima AST i ALT u odnosu na primenjenu dozu olova, dok je u slučaju ALP ustanovljeno da veća doza olova ima za posledicu značajnije povećanje aktivnosti ovog enzima u krvnom serumu. U mladunaca ženki koje su tokom trudnoće i laktacije primale olovo, takođe je ustanovljeno značajno povećanje aktivnosti navedenih enzima u krvnom serumu u odnosu na kontrolnu grupu. Nisu ustanovljene značajne razlike u aktivnosti AST, ALT i ALP u serumu mladunaca u pogledu doze olova koje su njihove majke primale. Povećanje aktivnosti enzima AST, ALT i ALP u krvnom serumu ženki i mladunaca je najverovatnije posledica hepatotoksičnog dejstva olova udruženog sa intrahepatičkom holestazom.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - The influence of chronic lead poisoning on the activity of some serum enzymes in rats
T1  - Uticaj hroničnog trovanja olovom na aktivnost nekih enzima u krvnom serumu pacova
VL  - 55
IS  - 5-6
SP  - 471
EP  - 482
DO  - 10.2298/AVB0506471T
ER  - 

@article{
author = "Todorović, Tatjana and Dožić, I. and Vujanović, Dragana and Pejović, J. and Marjanović, Marjan",
year = "2005",
abstract = "In this paper, the influence of chronic lead intoxication on the activity of serum enzymes aspartate and alanine aminotransferases (AST and ALT) and alkaline phosphatase (ALP) was examined. The experiment was performed on 130 adult female DA rats and 80 young rats. Rats were treated by lead-acetate 100 and 30 mg Pb per kg body weight for 10, 20, 30, 40, 50 and 60 days. Young rats (offspring of studied female rats) were treated with lead only through the placenta and mother's milk. The activities of serum AST, ALT and ALP were determined spectrophotomerically by IFCC method. The activity of examined serum enzymes was significantly increased in conditions of chronic lead intoxication in female rats and their offspring in relation to the control group. The activity of serum AST, ALT and ALP was in a positive correlation with the time of intoxication. There were no significant differences between the activities of enzymes AST and ALT in the serum and the amount of lead. The activity of ALP was significantly higher in serum of rats treated with higher amounts of lead. Increased AST, ALT and ALP activity in serum is most likely the consequence of lead hepatotoxicity., U ovom radu su prikazani rezultati ispitivanja uticaja hroničnog trovanja olovom na aktivnost enzima aspartat i alanin aminotransferaze (AST i ALT) kao i alkalne fosfataze (ALP) u krvnom serumu pacova. Eksperiment je izveden na 130 ženki pacova i njihovih 80 mladunaca. Ženke su tretirane olovo-acetatom oralno putem pijaće vode u dve doze-100 i 30 mg/kg TM dnevno u trajanju od 10,20,30, 40, 50 i 60 dana, dok su njihovi mladunci olovo primali samo preko placente i putem mleka. Nakon žrtvovanja, od životinja je uzimana krv i u krvnom serumu je spektrofotometrijski, na automatskom analizatoru Hitachi 911, određivana aktivnost enzima AST, ALT i ALR Dobijeni rezultati su ukazali da hronično trovanje olovom ima za posledicu značajno povećanje aktivnosti enzima AST, ALT i ALP u krvnom serumu ženki pacova, pri čemu se aktivnost navedenih enzima linearno povećavala sa povećanjem vremena intoksikacije. Nisu zapažene značajne razlike u aktivnosti enzima AST i ALT u odnosu na primenjenu dozu olova, dok je u slučaju ALP ustanovljeno da veća doza olova ima za posledicu značajnije povećanje aktivnosti ovog enzima u krvnom serumu. U mladunaca ženki koje su tokom trudnoće i laktacije primale olovo, takođe je ustanovljeno značajno povećanje aktivnosti navedenih enzima u krvnom serumu u odnosu na kontrolnu grupu. Nisu ustanovljene značajne razlike u aktivnosti AST, ALT i ALP u serumu mladunaca u pogledu doze olova koje su njihove majke primale. Povećanje aktivnosti enzima AST, ALT i ALP u krvnom serumu ženki i mladunaca je najverovatnije posledica hepatotoksičnog dejstva olova udruženog sa intrahepatičkom holestazom.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "The influence of chronic lead poisoning on the activity of some serum enzymes in rats, Uticaj hroničnog trovanja olovom na aktivnost nekih enzima u krvnom serumu pacova",
volume = "55",
number = "5-6",
pages = "471-482",
doi = "10.2298/AVB0506471T"
}

Todorović, T., Dožić, I., Vujanović, D., Pejović, J.,& Marjanović, M.. (2005). The influence of chronic lead poisoning on the activity of some serum enzymes in rats. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 55(5-6), 471-482.
https://doi.org/10.2298/AVB0506471T

Todorović T, Dožić I, Vujanović D, Pejović J, Marjanović M. The influence of chronic lead poisoning on the activity of some serum enzymes in rats. in Acta veterinaria. 2005;55(5-6):471-482.
doi:10.2298/AVB0506471T .

Todorović, Tatjana, Dožić, I., Vujanović, Dragana, Pejović, J., Marjanović, Marjan, "The influence of chronic lead poisoning on the activity of some serum enzymes in rats" in Acta veterinaria, 55, no. 5-6 (2005):471-482,
https://doi.org/10.2298/AVB0506471T . .