TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Jovanović, M
AU  - Stanišić, Verica
AU  - Ninić, Ana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3142
AB  - Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity. Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained. Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = − 0.489, p < 0.001) are the independent predictors of XO activity (R2-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction. Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population. Level of Evidence: Level V: cross-sectional descriptive study.
PB  - Springer International Publishing
T2  - Eating and Weight Disorders
T1  - Body mass index is independently associated with xanthine oxidase activity in overweight/obese population
VL  - 25
IS  - 1
SP  - 9
EP  - 15
DO  - 10.1007/s40519-018-0490-5
ER  - 

@article{
author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Jovanović, M and Stanišić, Verica and Ninić, Ana",
year = "2020",
abstract = "Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity. Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained. Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = − 0.489, p < 0.001) are the independent predictors of XO activity (R2-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction. Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population. Level of Evidence: Level V: cross-sectional descriptive study.",
publisher = "Springer International Publishing",
journal = "Eating and Weight Disorders",
title = "Body mass index is independently associated with xanthine oxidase activity in overweight/obese population",
volume = "25",
number = "1",
pages = "9-15",
doi = "10.1007/s40519-018-0490-5"
}

Klisić, A., Kocić, G., Kavarić, N., Jovanović, M., Stanišić, V.,& Ninić, A.. (2020). Body mass index is independently associated with xanthine oxidase activity in overweight/obese population. in Eating and Weight Disorders
Springer International Publishing., 25(1), 9-15.
https://doi.org/10.1007/s40519-018-0490-5

Klisić A, Kocić G, Kavarić N, Jovanović M, Stanišić V, Ninić A. Body mass index is independently associated with xanthine oxidase activity in overweight/obese population. in Eating and Weight Disorders. 2020;25(1):9-15.
doi:10.1007/s40519-018-0490-5 .

Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Jovanović, M, Stanišić, Verica, Ninić, Ana, "Body mass index is independently associated with xanthine oxidase activity in overweight/obese population" in Eating and Weight Disorders, 25, no. 1 (2020):9-15,
https://doi.org/10.1007/s40519-018-0490-5 . .

TY  - JOUR
AU  - Radulović, Valentina
AU  - Aleksić, Mara
AU  - Kapetanović, Vera
AU  - Rajić, K.K
AU  - Jovanović, M
AU  - Marjanović, I
AU  - Stojković, M
AU  - Agbaba, Danica
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3286
AB  - A novel voltammetric method was developed for brimonidine (BRIM) determination in deproteinized aqueous humor, simplifying preparation of biological samples for analysis for stability studies. The differential pulse voltammetric (DPV) method using boron doped diamond electrode (BDDE), based on characteristic oxidation peaks, was proposed and successfully applied. The linearity range was within 5.0 × 10−6 to 5.0 × 10−5 M of brimonidine, and limit of detection and limit of quantitation were 1.94 × 10−6 M and 6.46 × 10−6 M, respectively. Intra-day and inter-day precision and accuracy were evaluated and all results were in accordance with validation ICH guidelines. The best short-term stability study results were obtained for a concentration level of 3.0 × 10−5 M expressed by deviation of + 1.86% between initial and post storage concentrations. A long-term stability study was performed for two concentrations of 3.0 × 10−5 M and 5.0 × 10−5 M and resulted in deviations of + 1.63% and + 3.56%, respectively. A freeze and thaw stability study indicated that samples might be frozen only once. The enhancement of DPV/BDDE method sensitivity gained by modification, for the analysis of immeasurable BRIM quantities in native, untreated aqueous humor, was reached for quantities of 6 or 12 nmol/0.1 mL aqueous humor with acceptable accuracy (up to + 7.5%). The nature of the process—the irreversible one electron oxidation voltammetric peak of BRIM—limited the sensitivity. Only electrochemical pre-treatment of the BDD electrode before each measurement significantly speeded up the whole procedure. The advantages of the proposed method are simplicity, short-time performance, and good specificity/selectivity, as well as satisfactory accuracy, and no chemical modification of BDDE was necessary.
PB  - Springer Verlag
T2  - Analytical and Bioanalytical Chemistry
T1  - The evaluation of short- and long-term stability studies for brimonidine in aqueous humor by DPV/BDDE method—possible application for direct assay in native samples
DO  - 10.1007/s00216-019-01955-3
ER  - 

@article{
author = "Radulović, Valentina and Aleksić, Mara and Kapetanović, Vera and Rajić, K.K and Jovanović, M and Marjanović, I and Stojković, M and Agbaba, Danica",
year = "2019",
abstract = "A novel voltammetric method was developed for brimonidine (BRIM) determination in deproteinized aqueous humor, simplifying preparation of biological samples for analysis for stability studies. The differential pulse voltammetric (DPV) method using boron doped diamond electrode (BDDE), based on characteristic oxidation peaks, was proposed and successfully applied. The linearity range was within 5.0 × 10−6 to 5.0 × 10−5 M of brimonidine, and limit of detection and limit of quantitation were 1.94 × 10−6 M and 6.46 × 10−6 M, respectively. Intra-day and inter-day precision and accuracy were evaluated and all results were in accordance with validation ICH guidelines. The best short-term stability study results were obtained for a concentration level of 3.0 × 10−5 M expressed by deviation of + 1.86% between initial and post storage concentrations. A long-term stability study was performed for two concentrations of 3.0 × 10−5 M and 5.0 × 10−5 M and resulted in deviations of + 1.63% and + 3.56%, respectively. A freeze and thaw stability study indicated that samples might be frozen only once. The enhancement of DPV/BDDE method sensitivity gained by modification, for the analysis of immeasurable BRIM quantities in native, untreated aqueous humor, was reached for quantities of 6 or 12 nmol/0.1 mL aqueous humor with acceptable accuracy (up to + 7.5%). The nature of the process—the irreversible one electron oxidation voltammetric peak of BRIM—limited the sensitivity. Only electrochemical pre-treatment of the BDD electrode before each measurement significantly speeded up the whole procedure. The advantages of the proposed method are simplicity, short-time performance, and good specificity/selectivity, as well as satisfactory accuracy, and no chemical modification of BDDE was necessary.",
publisher = "Springer Verlag",
journal = "Analytical and Bioanalytical Chemistry",
title = "The evaluation of short- and long-term stability studies for brimonidine in aqueous humor by DPV/BDDE method—possible application for direct assay in native samples",
doi = "10.1007/s00216-019-01955-3"
}

Radulović, V., Aleksić, M., Kapetanović, V., Rajić, K.K, Jovanović, M., Marjanović, I., Stojković, M.,& Agbaba, D.. (2019). The evaluation of short- and long-term stability studies for brimonidine in aqueous humor by DPV/BDDE method—possible application for direct assay in native samples. in Analytical and Bioanalytical Chemistry
Springer Verlag..
https://doi.org/10.1007/s00216-019-01955-3

Radulović V, Aleksić M, Kapetanović V, Rajić K, Jovanović M, Marjanović I, Stojković M, Agbaba D. The evaluation of short- and long-term stability studies for brimonidine in aqueous humor by DPV/BDDE method—possible application for direct assay in native samples. in Analytical and Bioanalytical Chemistry. 2019;.
doi:10.1007/s00216-019-01955-3 .

Radulović, Valentina, Aleksić, Mara, Kapetanović, Vera, Rajić, K.K, Jovanović, M, Marjanović, I, Stojković, M, Agbaba, Danica, "The evaluation of short- and long-term stability studies for brimonidine in aqueous humor by DPV/BDDE method—possible application for direct assay in native samples" in Analytical and Bioanalytical Chemistry (2019),
https://doi.org/10.1007/s00216-019-01955-3 . .

TY  - CONF
AU  - Vučinić, Slavica
AU  - Kilibarda, Vesna
AU  - Jović-Stošić, Jasmina
AU  - Jovanović, M.
AU  - Antonijević, Biljana
AU  - Antonijević, Evica
AU  - Brajković, Gordana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2371
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions
VL  - 238
IS  - 2, Supplement
SP  - S145
EP  - S145
DO  - 10.1016/j.toxlet.2015.08.456
ER  - 

@conference{
author = "Vučinić, Slavica and Kilibarda, Vesna and Jović-Stošić, Jasmina and Jovanović, M. and Antonijević, Biljana and Antonijević, Evica and Brajković, Gordana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions",
volume = "238",
number = "2, Supplement",
pages = "S145-S145",
doi = "10.1016/j.toxlet.2015.08.456"
}

Vučinić, S., Kilibarda, V., Jović-Stošić, J., Jovanović, M., Antonijević, B., Antonijević, E.,& Brajković, G.. (2015). Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 238(2, Supplement), S145-S145.
https://doi.org/10.1016/j.toxlet.2015.08.456

Vučinić S, Kilibarda V, Jović-Stošić J, Jovanović M, Antonijević B, Antonijević E, Brajković G. Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions. in Toxicology Letters. 2015;238(2, Supplement):S145-S145.
doi:10.1016/j.toxlet.2015.08.456 .

Vučinić, Slavica, Kilibarda, Vesna, Jović-Stošić, Jasmina, Jovanović, M., Antonijević, Biljana, Antonijević, Evica, Brajković, Gordana, "Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions" in Toxicology Letters, 238, no. 2, Supplement (2015):S145-S145,
https://doi.org/10.1016/j.toxlet.2015.08.456 . .

TY  - CONF
AU  - Knjeginjić, M.
AU  - Cvijanović, Cuic C.
AU  - Dabić, N.
AU  - Jovanović, M.
AU  - Vezmar-Kovačević, Sandra
AU  - Ćulafić, Milica
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1993
PB  - Springer
C3  - International Journal of Clinical Pharmacy
T1  - Patients' knowledge of pen-insulin therapy
VL  - 35
IS  - 3
SP  - 500
EP  - 500
DO  - 10.1007/s11096-013-9773-0
ER  - 

@conference{
author = "Knjeginjić, M. and Cvijanović, Cuic C. and Dabić, N. and Jovanović, M. and Vezmar-Kovačević, Sandra and Ćulafić, Milica",
year = "2013",
publisher = "Springer",
journal = "International Journal of Clinical Pharmacy",
title = "Patients' knowledge of pen-insulin therapy",
volume = "35",
number = "3",
pages = "500-500",
doi = "10.1007/s11096-013-9773-0"
}

Knjeginjić, M., Cvijanović, C. C., Dabić, N., Jovanović, M., Vezmar-Kovačević, S.,& Ćulafić, M.. (2013). Patients' knowledge of pen-insulin therapy. in International Journal of Clinical Pharmacy
Springer., 35(3), 500-500.
https://doi.org/10.1007/s11096-013-9773-0

Knjeginjić M, Cvijanović CC, Dabić N, Jovanović M, Vezmar-Kovačević S, Ćulafić M. Patients' knowledge of pen-insulin therapy. in International Journal of Clinical Pharmacy. 2013;35(3):500-500.
doi:10.1007/s11096-013-9773-0 .

Knjeginjić, M., Cvijanović, Cuic C., Dabić, N., Jovanović, M., Vezmar-Kovačević, Sandra, Ćulafić, Milica, "Patients' knowledge of pen-insulin therapy" in International Journal of Clinical Pharmacy, 35, no. 3 (2013):500-500,
https://doi.org/10.1007/s11096-013-9773-0 . .

TY  - CONF
AU  - Vučinić, Slavica
AU  - Antonijević, Biljana
AU  - Zlatković, M.
AU  - Đorđević, D.
AU  - Jovanović, M.
AU  - Ćurčić, Marijana
AU  - Kilibarda, Vesna
AU  - Bokonjić, Dubravko
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1469
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - How have the latest trends in toxicology of organophosphates affected our clinical practice?
VL  - 205
IS  - Supplement
SP  - S56
EP  - S56
DO  - 10.1016/j.toxlet.2011.05.215
ER  - 

@conference{
author = "Vučinić, Slavica and Antonijević, Biljana and Zlatković, M. and Đorđević, D. and Jovanović, M. and Ćurčić, Marijana and Kilibarda, Vesna and Bokonjić, Dubravko",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "How have the latest trends in toxicology of organophosphates affected our clinical practice?",
volume = "205",
number = "Supplement",
pages = "S56-S56",
doi = "10.1016/j.toxlet.2011.05.215"
}

Vučinić, S., Antonijević, B., Zlatković, M., Đorđević, D., Jovanović, M., Ćurčić, M., Kilibarda, V.,& Bokonjić, D.. (2011). How have the latest trends in toxicology of organophosphates affected our clinical practice?. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 205(Supplement), S56-S56.
https://doi.org/10.1016/j.toxlet.2011.05.215

Vučinić S, Antonijević B, Zlatković M, Đorđević D, Jovanović M, Ćurčić M, Kilibarda V, Bokonjić D. How have the latest trends in toxicology of organophosphates affected our clinical practice?. in Toxicology Letters. 2011;205(Supplement):S56-S56.
doi:10.1016/j.toxlet.2011.05.215 .

Vučinić, Slavica, Antonijević, Biljana, Zlatković, M., Đorđević, D., Jovanović, M., Ćurčić, Marijana, Kilibarda, Vesna, Bokonjić, Dubravko, "How have the latest trends in toxicology of organophosphates affected our clinical practice?" in Toxicology Letters, 205, no. Supplement (2011):S56-S56,
https://doi.org/10.1016/j.toxlet.2011.05.215 . .

TY  - JOUR
AU  - Davidović, Vesna
AU  - Lazarević, M.
AU  - Joksimović-Todorović, Mirjana
AU  - Maksimović, Zoran
AU  - Jovanović, M.
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1441
AB  - The objective of this research was to study the effects that the extract of rhizome and root of Helleborus odorus W. et K. (Ranunculaceae) can have on modifications in the parameter values of white blood cells count and degree of phagocytosis by peritoneal macrophages and neutrophil granulocytes in Wistar rats. The trial was conducted on 28 rats divided into 4 groups with 7 animals in each group. To the control group of rats sterile physiological solution in the quantity of 0.25 mL/100 g BW was applied intramuscularly. For the purpose of monitoring the effect of the extract of rhizome and root of hellebore (HE) during a time period, the HE was applied intramuscularly to rats in a dose of 10 mg/100 g BW, while the blood samples for analysis were taken after 24h, 48h and 72h. The consequence of intramuscular application of HE was an increased count of total leukocytes in all trial groups, the most expressed leukocytosis being registered 24h after application of HE. Statistically significant higher value in the count and percent of neutrophil granulocytes in the blood was recorded 24h after treatment in relation to the control and two other trial groups (p lt 0.001), among which a statistical significance was not established. The extract of hellebore rhizome and root has led to lymphopenia, resulting in the increase of the neutrophil/limphocyte index in the trial groups 24h and 48h after treatment. The application of HE had no significant effect on the count of monocytes in treated animals. The applied extract has caused a significant increase in the degree of phagocytosis by residing peritoneal macrophages and neutrophil granulocytes in blood.
AB  - Cilj ovog rada je bio da se ispita uticaj ekstrakta rizoma i korena H. odorus W. et K. na promenu vrednosti parametara bele krvne slike i stepen fagocitoze od strane peritonealnih makrofaga i neutrofilnih granulocita kod pacova soja Wistar. Ogled je izveden na 28 pacova podeljenih u 4 grupe po 7 jedinki. Kontrolnoj grupi pacova je intramuskularno aplikovan sterilan fiziološki rastvor u količini od 0,25 ml/100 g TM. U cilju praćenja efekta ekstrakta rizoma i korena kukureka (EK) u toku vremena, pacovima je intramuskularno aplikovan EK u dozi od 10mg/100g TM, a krv za analizu je uzimana posle 24h, 48h i 72h. Intramuskularna aplikacija EK imala je za posledicu povećanje broja ukupnih leukocita u svim oglednim grupama, pri čemu je najizraženija leukocitoza registrovana 24h nakon aplikovanja EK. Statistički značajno veća vrednost broja i procenta neutrofilnih granulocita u krvi zabeležena je 24h posle tretmana u odnosu na kontrolnu i ostale dve ogledne grupe (p lt 0,001), između kojih nije utvrđena statistička značajnost. Ekstrakt rizoma i korena kukureka doveo je do nastanka limfopenije, što je imalo za posledicu povećanje neutrofilno/limfocitnog indeksa u oglednim grupama 24h i 48h nakon tretmana. Aplikacija EK nije značajno uticala na broj monocita kod tretiranih životinja. Upotrebljeni ekstrakt doveo je do značajnog povećanja stepena fagocitoze od strane rezidentnih peritonealnih makrofaga i neutrofilnih granulocita krvi.
PB  - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
T2  - Acta veterinaria
T1  - The effect of the extract of rhizome and root of hellebore (Helleborus odorus W. et K.) on parameters of white blood count and degree of phagocytosis in wistar rats
T1  - Uticaj ekstrakta rizoma i korena kukureka (Helleborus odorus W. et K.) na parametre bele krvne slike i stepen fagocitoze kod wistar pacova
VL  - 60
IS  - 5-6
SP  - 605
EP  - 618
DO  - 10.2298/AVB1006605D
ER  - 

@article{
author = "Davidović, Vesna and Lazarević, M. and Joksimović-Todorović, Mirjana and Maksimović, Zoran and Jovanović, M.",
year = "2010",
abstract = "The objective of this research was to study the effects that the extract of rhizome and root of Helleborus odorus W. et K. (Ranunculaceae) can have on modifications in the parameter values of white blood cells count and degree of phagocytosis by peritoneal macrophages and neutrophil granulocytes in Wistar rats. The trial was conducted on 28 rats divided into 4 groups with 7 animals in each group. To the control group of rats sterile physiological solution in the quantity of 0.25 mL/100 g BW was applied intramuscularly. For the purpose of monitoring the effect of the extract of rhizome and root of hellebore (HE) during a time period, the HE was applied intramuscularly to rats in a dose of 10 mg/100 g BW, while the blood samples for analysis were taken after 24h, 48h and 72h. The consequence of intramuscular application of HE was an increased count of total leukocytes in all trial groups, the most expressed leukocytosis being registered 24h after application of HE. Statistically significant higher value in the count and percent of neutrophil granulocytes in the blood was recorded 24h after treatment in relation to the control and two other trial groups (p lt 0.001), among which a statistical significance was not established. The extract of hellebore rhizome and root has led to lymphopenia, resulting in the increase of the neutrophil/limphocyte index in the trial groups 24h and 48h after treatment. The application of HE had no significant effect on the count of monocytes in treated animals. The applied extract has caused a significant increase in the degree of phagocytosis by residing peritoneal macrophages and neutrophil granulocytes in blood., Cilj ovog rada je bio da se ispita uticaj ekstrakta rizoma i korena H. odorus W. et K. na promenu vrednosti parametara bele krvne slike i stepen fagocitoze od strane peritonealnih makrofaga i neutrofilnih granulocita kod pacova soja Wistar. Ogled je izveden na 28 pacova podeljenih u 4 grupe po 7 jedinki. Kontrolnoj grupi pacova je intramuskularno aplikovan sterilan fiziološki rastvor u količini od 0,25 ml/100 g TM. U cilju praćenja efekta ekstrakta rizoma i korena kukureka (EK) u toku vremena, pacovima je intramuskularno aplikovan EK u dozi od 10mg/100g TM, a krv za analizu je uzimana posle 24h, 48h i 72h. Intramuskularna aplikacija EK imala je za posledicu povećanje broja ukupnih leukocita u svim oglednim grupama, pri čemu je najizraženija leukocitoza registrovana 24h nakon aplikovanja EK. Statistički značajno veća vrednost broja i procenta neutrofilnih granulocita u krvi zabeležena je 24h posle tretmana u odnosu na kontrolnu i ostale dve ogledne grupe (p lt 0,001), između kojih nije utvrđena statistička značajnost. Ekstrakt rizoma i korena kukureka doveo je do nastanka limfopenije, što je imalo za posledicu povećanje neutrofilno/limfocitnog indeksa u oglednim grupama 24h i 48h nakon tretmana. Aplikacija EK nije značajno uticala na broj monocita kod tretiranih životinja. Upotrebljeni ekstrakt doveo je do značajnog povećanja stepena fagocitoze od strane rezidentnih peritonealnih makrofaga i neutrofilnih granulocita krvi.",
publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd",
journal = "Acta veterinaria",
title = "The effect of the extract of rhizome and root of hellebore (Helleborus odorus W. et K.) on parameters of white blood count and degree of phagocytosis in wistar rats, Uticaj ekstrakta rizoma i korena kukureka (Helleborus odorus W. et K.) na parametre bele krvne slike i stepen fagocitoze kod wistar pacova",
volume = "60",
number = "5-6",
pages = "605-618",
doi = "10.2298/AVB1006605D"
}

Davidović, V., Lazarević, M., Joksimović-Todorović, M., Maksimović, Z.,& Jovanović, M.. (2010). The effect of the extract of rhizome and root of hellebore (Helleborus odorus W. et K.) on parameters of white blood count and degree of phagocytosis in wistar rats. in Acta veterinaria
Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 60(5-6), 605-618.
https://doi.org/10.2298/AVB1006605D

Davidović V, Lazarević M, Joksimović-Todorović M, Maksimović Z, Jovanović M. The effect of the extract of rhizome and root of hellebore (Helleborus odorus W. et K.) on parameters of white blood count and degree of phagocytosis in wistar rats. in Acta veterinaria. 2010;60(5-6):605-618.
doi:10.2298/AVB1006605D .

Davidović, Vesna, Lazarević, M., Joksimović-Todorović, Mirjana, Maksimović, Zoran, Jovanović, M., "The effect of the extract of rhizome and root of hellebore (Helleborus odorus W. et K.) on parameters of white blood count and degree of phagocytosis in wistar rats" in Acta veterinaria, 60, no. 5-6 (2010):605-618,
https://doi.org/10.2298/AVB1006605D . .

TY  - CONF
AU  - Brborić, Jasmina
AU  - Jovanović, M.
AU  - Ivković, Branka
AU  - Vladimirov, S.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/749
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - RP-HPLC metoda za određivanje hemijske čistoće analoga iminodisirćetne kiseline-liganada u 99mTC-radiofarmačeutičima za hepatobilijarnu scintigrafiju
T1  - RP-HPLC method for the determination of purity of iminodiacetic acid analogs-ligands in 99mTC-radiopharmaceuticals for hepatobiliary scintigraphy
VL  - 56
IS  - 5
SP  - 730
EP  - 731
UR  - https://hdl.handle.net/21.15107/rcub_farfar_749
ER  - 

@conference{
author = "Brborić, Jasmina and Jovanović, M. and Ivković, Branka and Vladimirov, S.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "RP-HPLC metoda za određivanje hemijske čistoće analoga iminodisirćetne kiseline-liganada u 99mTC-radiofarmačeutičima za hepatobilijarnu scintigrafiju, RP-HPLC method for the determination of purity of iminodiacetic acid analogs-ligands in 99mTC-radiopharmaceuticals for hepatobiliary scintigraphy",
volume = "56",
number = "5",
pages = "730-731",
url = "https://hdl.handle.net/21.15107/rcub_farfar_749"
}

Brborić, J., Jovanović, M., Ivković, B.,& Vladimirov, S.. (2006). RP-HPLC metoda za određivanje hemijske čistoće analoga iminodisirćetne kiseline-liganada u 99mTC-radiofarmačeutičima za hepatobilijarnu scintigrafiju. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(5), 730-731.
https://hdl.handle.net/21.15107/rcub_farfar_749

Brborić J, Jovanović M, Ivković B, Vladimirov S. RP-HPLC metoda za određivanje hemijske čistoće analoga iminodisirćetne kiseline-liganada u 99mTC-radiofarmačeutičima za hepatobilijarnu scintigrafiju. in Arhiv za farmaciju. 2006;56(5):730-731.
https://hdl.handle.net/21.15107/rcub_farfar_749 .

Brborić, Jasmina, Jovanović, M., Ivković, Branka, Vladimirov, S., "RP-HPLC metoda za određivanje hemijske čistoće analoga iminodisirćetne kiseline-liganada u 99mTC-radiofarmačeutičima za hepatobilijarnu scintigrafiju" in Arhiv za farmaciju, 56, no. 5 (2006):730-731,
https://hdl.handle.net/21.15107/rcub_farfar_749 .

TY  - CONF
AU  - Ćurčić-Jovanović, Marijana
AU  - Đukić, Mirjana
AU  - Ninković, Milica
AU  - Vasiljević, Ivana
AU  - Jovanović, M.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/790
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Influence of naloxone pretreatment on nitric oxide levels in diquat neurotoxicity
T1  - Uticaj pretretmana naloksonom na sadržaj azot(II)-oksida u neurotoksičnosti dikvata
VL  - 56
IS  - 4
SP  - 608
EP  - 609
UR  - https://hdl.handle.net/21.15107/rcub_farfar_790
ER  - 

@conference{
author = "Ćurčić-Jovanović, Marijana and Đukić, Mirjana and Ninković, Milica and Vasiljević, Ivana and Jovanović, M.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Influence of naloxone pretreatment on nitric oxide levels in diquat neurotoxicity, Uticaj pretretmana naloksonom na sadržaj azot(II)-oksida u neurotoksičnosti dikvata",
volume = "56",
number = "4",
pages = "608-609",
url = "https://hdl.handle.net/21.15107/rcub_farfar_790"
}

Ćurčić-Jovanović, M., Đukić, M., Ninković, M., Vasiljević, I.,& Jovanović, M.. (2006). Influence of naloxone pretreatment on nitric oxide levels in diquat neurotoxicity. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 608-609.
https://hdl.handle.net/21.15107/rcub_farfar_790

Ćurčić-Jovanović M, Đukić M, Ninković M, Vasiljević I, Jovanović M. Influence of naloxone pretreatment on nitric oxide levels in diquat neurotoxicity. in Arhiv za farmaciju. 2006;56(4):608-609.
https://hdl.handle.net/21.15107/rcub_farfar_790 .

Ćurčić-Jovanović, Marijana, Đukić, Mirjana, Ninković, Milica, Vasiljević, Ivana, Jovanović, M., "Influence of naloxone pretreatment on nitric oxide levels in diquat neurotoxicity" in Arhiv za farmaciju, 56, no. 4 (2006):608-609,
https://hdl.handle.net/21.15107/rcub_farfar_790 .

TY  - CONF
AU  - Cvijić, Sandra
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Ibrić, Svetlana
AU  - Jovanović, M.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/834
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Surface active agents in biorelevant dissolution media composition: Basic considerations and recent trends
T1  - Primena površinski aktivnih materija u medijumu za ispitivanje brzine rastvaranja lekovite supstance iz lekovitih preparata - osnovna razmatranja i savremeni trend
VL  - 56
IS  - 4
SP  - 438
EP  - 439
UR  - https://hdl.handle.net/21.15107/rcub_farfar_834
ER  - 

@conference{
author = "Cvijić, Sandra and Parojčić, Jelena and Đurić, Zorica and Ibrić, Svetlana and Jovanović, M.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Surface active agents in biorelevant dissolution media composition: Basic considerations and recent trends, Primena površinski aktivnih materija u medijumu za ispitivanje brzine rastvaranja lekovite supstance iz lekovitih preparata - osnovna razmatranja i savremeni trend",
volume = "56",
number = "4",
pages = "438-439",
url = "https://hdl.handle.net/21.15107/rcub_farfar_834"
}

Cvijić, S., Parojčić, J., Đurić, Z., Ibrić, S.,& Jovanović, M.. (2006). Surface active agents in biorelevant dissolution media composition: Basic considerations and recent trends. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 438-439.
https://hdl.handle.net/21.15107/rcub_farfar_834

Cvijić S, Parojčić J, Đurić Z, Ibrić S, Jovanović M. Surface active agents in biorelevant dissolution media composition: Basic considerations and recent trends. in Arhiv za farmaciju. 2006;56(4):438-439.
https://hdl.handle.net/21.15107/rcub_farfar_834 .

Cvijić, Sandra, Parojčić, Jelena, Đurić, Zorica, Ibrić, Svetlana, Jovanović, M., "Surface active agents in biorelevant dissolution media composition: Basic considerations and recent trends" in Arhiv za farmaciju, 56, no. 4 (2006):438-439,
https://hdl.handle.net/21.15107/rcub_farfar_834 .

TY  - CONF
AU  - Knežević, Marijana
AU  - Parojčić, Jelena
AU  - Ibrić, Svetlana
AU  - Đurić, Zorica
AU  - Jovanović, M.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/766
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Tablet disintegration and drug dissolution in viscous media: Aspirin immediate-release tablets
T1  - Ispitivanje raspadljivosti i brzine rastvaranja u viskoznom medijumu - tablete acetilsalicilne kiseline
VL  - 56
IS  - 4
SP  - 480
EP  - 481
UR  - https://hdl.handle.net/21.15107/rcub_farfar_766
ER  - 

@conference{
author = "Knežević, Marijana and Parojčić, Jelena and Ibrić, Svetlana and Đurić, Zorica and Jovanović, M.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Tablet disintegration and drug dissolution in viscous media: Aspirin immediate-release tablets, Ispitivanje raspadljivosti i brzine rastvaranja u viskoznom medijumu - tablete acetilsalicilne kiseline",
volume = "56",
number = "4",
pages = "480-481",
url = "https://hdl.handle.net/21.15107/rcub_farfar_766"
}

Knežević, M., Parojčić, J., Ibrić, S., Đurić, Z.,& Jovanović, M.. (2006). Tablet disintegration and drug dissolution in viscous media: Aspirin immediate-release tablets. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 480-481.
https://hdl.handle.net/21.15107/rcub_farfar_766

Knežević M, Parojčić J, Ibrić S, Đurić Z, Jovanović M. Tablet disintegration and drug dissolution in viscous media: Aspirin immediate-release tablets. in Arhiv za farmaciju. 2006;56(4):480-481.
https://hdl.handle.net/21.15107/rcub_farfar_766 .

Knežević, Marijana, Parojčić, Jelena, Ibrić, Svetlana, Đurić, Zorica, Jovanović, M., "Tablet disintegration and drug dissolution in viscous media: Aspirin immediate-release tablets" in Arhiv za farmaciju, 56, no. 4 (2006):480-481,
https://hdl.handle.net/21.15107/rcub_farfar_766 .

TY  - CONF
AU  - Đaniš, J.
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, M.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/786
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Evaluation of Pemulen® TR-2 as drug release modifier in matrix tablets. Part I: Paracetamol extended release tablets
T1  - Mogućnost promene Pemulen® TR-2 polimera u formulaciji hidrofilnih matriks tableta sa usporenim oslobađanjem paracetamola
VL  - 56
IS  - 4
SP  - 476
EP  - 477
UR  - https://hdl.handle.net/21.15107/rcub_farfar_786
ER  - 

@conference{
author = "Đaniš, J. and Ibrić, Svetlana and Parojčić, Jelena and Đurić, Zorica and Jovanović, M.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Evaluation of Pemulen® TR-2 as drug release modifier in matrix tablets. Part I: Paracetamol extended release tablets, Mogućnost promene Pemulen® TR-2 polimera u formulaciji hidrofilnih matriks tableta sa usporenim oslobađanjem paracetamola",
volume = "56",
number = "4",
pages = "476-477",
url = "https://hdl.handle.net/21.15107/rcub_farfar_786"
}

Đaniš, J., Ibrić, S., Parojčić, J., Đurić, Z.,& Jovanović, M.. (2006). Evaluation of Pemulen® TR-2 as drug release modifier in matrix tablets. Part I: Paracetamol extended release tablets. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 476-477.
https://hdl.handle.net/21.15107/rcub_farfar_786

Đaniš J, Ibrić S, Parojčić J, Đurić Z, Jovanović M. Evaluation of Pemulen® TR-2 as drug release modifier in matrix tablets. Part I: Paracetamol extended release tablets. in Arhiv za farmaciju. 2006;56(4):476-477.
https://hdl.handle.net/21.15107/rcub_farfar_786 .

Đaniš, J., Ibrić, Svetlana, Parojčić, Jelena, Đurić, Zorica, Jovanović, M., "Evaluation of Pemulen® TR-2 as drug release modifier in matrix tablets. Part I: Paracetamol extended release tablets" in Arhiv za farmaciju, 56, no. 4 (2006):476-477,
https://hdl.handle.net/21.15107/rcub_farfar_786 .

TY  - CONF
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Grbić, S
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/613
PB  - Elsevier Science BV, Amsterdam
C3  - European Journal of Pharmaceutical Sciences
T1  - Predicting in vivo behavior of sustained release matrix tablet formulation: numerical convolution versus artificial neural network analysis
VL  - 25
IS  - SUPPL. 1
UR  - https://hdl.handle.net/21.15107/rcub_farfar_613
ER  - 

@conference{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Grbić, S",
year = "2005",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Predicting in vivo behavior of sustained release matrix tablet formulation: numerical convolution versus artificial neural network analysis",
volume = "25",
number = "SUPPL. 1",
url = "https://hdl.handle.net/21.15107/rcub_farfar_613"
}

Parojčić, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Grbić, S.. (2005). Predicting in vivo behavior of sustained release matrix tablet formulation: numerical convolution versus artificial neural network analysis. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 25(SUPPL. 1).
https://hdl.handle.net/21.15107/rcub_farfar_613

Parojčić J, Đurić Z, Jovanović M, Ibrić S, Grbić S. Predicting in vivo behavior of sustained release matrix tablet formulation: numerical convolution versus artificial neural network analysis. in European Journal of Pharmaceutical Sciences. 2005;25(SUPPL. 1).
https://hdl.handle.net/21.15107/rcub_farfar_613 .

Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Grbić, S, "Predicting in vivo behavior of sustained release matrix tablet formulation: numerical convolution versus artificial neural network analysis" in European Journal of Pharmaceutical Sciences, 25, no. SUPPL. 1 (2005),
https://hdl.handle.net/21.15107/rcub_farfar_613 .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Kilibarda, Vesna
AU  - Jovanović, D
AU  - Kovacević, I
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/594
AB  - With the increased interest in modified release dosage forms and drug delivery systems, there is an increasing concern for biopharmaceutical characterization of the formulation in the early stages of drug product development. The main objectives of biopharmaceutical characterization are the in vitro and in vivo evaluation of the selected formulations in order to identify the factors influencing drug release; define the in vitro test methodology that would be predictive of drug products in vivo behavior and develop quantitative in vitro - in vivo correlation. The purpose of this study was to assess the potential of novel carbomer polymers, Carbopol 971P and Carbopol 71G, as a sustained release agents in matrix tablets containing high dosage drug substance. Although chemically identical, the two polymers exhibited substantially different drug release properties in vitro. Hypothetical in vivo drug release profiles were calculated by numerical deconvolution from cumulative urinary excretion data observed in vivo. The obtained results indicated that sound and reliable in vivo drug release profiles could be obtained from urinary excretion data and also, emphasized the need for in vitro testing under a range of experimental conditions in order to develop the biorelevant drug release methodology.
PB  - Springer France, Paris
T2  - European Journal of Drug Metabolism and Pharmacokinetics
T1  - Biopharmaceutical characterization of sustained release matrix tablets based on novel carbomer polymers: formulation and in vivo investigation
VL  - 30
IS  - 1-2
SP  - 99
EP  - 104
DO  - 10.1007/BF03226414
ER  - 

@article{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Kilibarda, Vesna and Jovanović, D and Kovacević, I",
year = "2005",
abstract = "With the increased interest in modified release dosage forms and drug delivery systems, there is an increasing concern for biopharmaceutical characterization of the formulation in the early stages of drug product development. The main objectives of biopharmaceutical characterization are the in vitro and in vivo evaluation of the selected formulations in order to identify the factors influencing drug release; define the in vitro test methodology that would be predictive of drug products in vivo behavior and develop quantitative in vitro - in vivo correlation. The purpose of this study was to assess the potential of novel carbomer polymers, Carbopol 971P and Carbopol 71G, as a sustained release agents in matrix tablets containing high dosage drug substance. Although chemically identical, the two polymers exhibited substantially different drug release properties in vitro. Hypothetical in vivo drug release profiles were calculated by numerical deconvolution from cumulative urinary excretion data observed in vivo. The obtained results indicated that sound and reliable in vivo drug release profiles could be obtained from urinary excretion data and also, emphasized the need for in vitro testing under a range of experimental conditions in order to develop the biorelevant drug release methodology.",
publisher = "Springer France, Paris",
journal = "European Journal of Drug Metabolism and Pharmacokinetics",
title = "Biopharmaceutical characterization of sustained release matrix tablets based on novel carbomer polymers: formulation and in vivo investigation",
volume = "30",
number = "1-2",
pages = "99-104",
doi = "10.1007/BF03226414"
}

Parojčić, J., Đurić, Z., Jovanović, M., Ibrić, S., Kilibarda, V., Jovanović, D.,& Kovacević, I.. (2005). Biopharmaceutical characterization of sustained release matrix tablets based on novel carbomer polymers: formulation and in vivo investigation. in European Journal of Drug Metabolism and Pharmacokinetics
Springer France, Paris., 30(1-2), 99-104.
https://doi.org/10.1007/BF03226414

Parojčić J, Đurić Z, Jovanović M, Ibrić S, Kilibarda V, Jovanović D, Kovacević I. Biopharmaceutical characterization of sustained release matrix tablets based on novel carbomer polymers: formulation and in vivo investigation. in European Journal of Drug Metabolism and Pharmacokinetics. 2005;30(1-2):99-104.
doi:10.1007/BF03226414 .

Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Kilibarda, Vesna, Jovanović, D, Kovacević, I, "Biopharmaceutical characterization of sustained release matrix tablets based on novel carbomer polymers: formulation and in vivo investigation" in European Journal of Drug Metabolism and Pharmacokinetics, 30, no. 1-2 (2005):99-104,
https://doi.org/10.1007/BF03226414 . .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/499
AB  - Drug release from hydrophilic matrix tablets can be strongly influenced by the proportion of matrix forming polymer and the dimensions and geometry of the tablets. A complete two-factor, three-level factorial design, followed by multiple regression analysis and response surface methodology, was applied to investigate the influence of polymer level and tablet size on drug release kinetics from hydrophilic matrix tablets prepared with Carbopol 971P and Carbopol 71G. Tablet diameter, radius-to-height ratio, tablet surface area, and surface-area-to-volume ratio were evaluated as independent variables in terms of their applicability to characterize tablet size and geometry. The results indicate that it may be possible to control the rate of drug release by modifying the proportion of carbomer in tablets and tablet dimensions. The practical benefit of these simulations is to optimize the geometry and dimensions of a controlled release device and reduce the number of experiments involved in the development of new controlled release dosage forms.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Delivery
T1  - An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers
VL  - 11
IS  - 1
SP  - 59
EP  - 65
DO  - 10.1080/10717540490265379
ER  - 

@article{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana",
year = "2004",
abstract = "Drug release from hydrophilic matrix tablets can be strongly influenced by the proportion of matrix forming polymer and the dimensions and geometry of the tablets. A complete two-factor, three-level factorial design, followed by multiple regression analysis and response surface methodology, was applied to investigate the influence of polymer level and tablet size on drug release kinetics from hydrophilic matrix tablets prepared with Carbopol 971P and Carbopol 71G. Tablet diameter, radius-to-height ratio, tablet surface area, and surface-area-to-volume ratio were evaluated as independent variables in terms of their applicability to characterize tablet size and geometry. The results indicate that it may be possible to control the rate of drug release by modifying the proportion of carbomer in tablets and tablet dimensions. The practical benefit of these simulations is to optimize the geometry and dimensions of a controlled release device and reduce the number of experiments involved in the development of new controlled release dosage forms.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Delivery",
title = "An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers",
volume = "11",
number = "1",
pages = "59-65",
doi = "10.1080/10717540490265379"
}

Parojčić, J., Đurić, Z., Jovanović, M.,& Ibrić, S.. (2004). An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers. in Drug Delivery
Taylor & Francis Ltd, Abingdon., 11(1), 59-65.
https://doi.org/10.1080/10717540490265379

Parojčić J, Đurić Z, Jovanović M, Ibrić S. An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers. in Drug Delivery. 2004;11(1):59-65.
doi:10.1080/10717540490265379 .

Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, "An investigation into the factors influencing drug release from hydrophilic matrix tablets based on novel carbomer polymers" in Drug Delivery, 11, no. 1 (2004):59-65,
https://doi.org/10.1080/10717540490265379 . .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Durić, J
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Jovanović, D
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/486
AB  - The influence of dissolution media composition on drug release kinetics and in-vitro/in-vivo correlation (IVIVC) for hydrophilic matrix tablets based on Carbopol 971P and Carbopol 71G was investigated. A number of buffered and unbuffered media differing with respect to their pH value, ionic strength and ionic species was evaluated. The observed in-vitro drug release profiles were compared with the hypothetical drug release profiles in-vivo calculated by numerical deconvolution from the results of an in-vivo study. The obtained IVIVC plots were examined using linear and non-linear (proportional odds, proportional hazards and proportional reversed hazards) mathematical models. Although the studied sustained release agents were chemically identical, they exhibited pronounced differences in drug product behaviour both in-vitro and in-vivo. The use of non-linear modelling resulted in an improved level of correlation, especially in the case of Carbopol 71G matrices. The obtained results indicated the susceptibility of drug release kinetics and hence IVIVC in the case of anionic polymer matrices to media composition, and emphasized the need for thorough evaluation of applied media during the development of biorelevant dissolution methodology. Although the use of non-linear modelling could be advantageous, the need for a simple and meaningful nonlinear relationship is pointed out.
PB  - Wiley, Hoboken
T2  - Journal of Pharmacy and Pharmacology
T1  - Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers
VL  - 56
IS  - 6
SP  - 735
EP  - 741
DO  - 10.1211/0022357023583
ER  - 

@article{
author = "Parojčić, Jelena and Durić, J and Jovanović, M and Ibrić, Svetlana and Jovanović, D",
year = "2004",
abstract = "The influence of dissolution media composition on drug release kinetics and in-vitro/in-vivo correlation (IVIVC) for hydrophilic matrix tablets based on Carbopol 971P and Carbopol 71G was investigated. A number of buffered and unbuffered media differing with respect to their pH value, ionic strength and ionic species was evaluated. The observed in-vitro drug release profiles were compared with the hypothetical drug release profiles in-vivo calculated by numerical deconvolution from the results of an in-vivo study. The obtained IVIVC plots were examined using linear and non-linear (proportional odds, proportional hazards and proportional reversed hazards) mathematical models. Although the studied sustained release agents were chemically identical, they exhibited pronounced differences in drug product behaviour both in-vitro and in-vivo. The use of non-linear modelling resulted in an improved level of correlation, especially in the case of Carbopol 71G matrices. The obtained results indicated the susceptibility of drug release kinetics and hence IVIVC in the case of anionic polymer matrices to media composition, and emphasized the need for thorough evaluation of applied media during the development of biorelevant dissolution methodology. Although the use of non-linear modelling could be advantageous, the need for a simple and meaningful nonlinear relationship is pointed out.",
publisher = "Wiley, Hoboken",
journal = "Journal of Pharmacy and Pharmacology",
title = "Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers",
volume = "56",
number = "6",
pages = "735-741",
doi = "10.1211/0022357023583"
}

Parojčić, J., Durić, J., Jovanović, M., Ibrić, S.,& Jovanović, D.. (2004). Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers. in Journal of Pharmacy and Pharmacology
Wiley, Hoboken., 56(6), 735-741.
https://doi.org/10.1211/0022357023583

Parojčić J, Durić J, Jovanović M, Ibrić S, Jovanović D. Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers. in Journal of Pharmacy and Pharmacology. 2004;56(6):735-741.
doi:10.1211/0022357023583 .

Parojčić, Jelena, Durić, J, Jovanović, M, Ibrić, Svetlana, Jovanović, D, "Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers" in Journal of Pharmacy and Pharmacology, 56, no. 6 (2004):735-741,
https://doi.org/10.1211/0022357023583 . .

TY  - CONF
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Stanojević, M
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/474
PB  - Slovenian Pharmaceutical Society
C3  - Farmacevtski Vestnik
T1  - An investigation into the influence of buffer media composition on drug release and in vitro - In vivo correlation for Carbopol 71G matrix tablets
VL  - 54
IS  - SPEC. ISS.
SP  - 355
EP  - 356
UR  - https://hdl.handle.net/21.15107/rcub_farfar_474
ER  - 

@conference{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Stanojević, M",
year = "2003",
publisher = "Slovenian Pharmaceutical Society",
journal = "Farmacevtski Vestnik",
title = "An investigation into the influence of buffer media composition on drug release and in vitro - In vivo correlation for Carbopol 71G matrix tablets",
volume = "54",
number = "SPEC. ISS.",
pages = "355-356",
url = "https://hdl.handle.net/21.15107/rcub_farfar_474"
}

Parojčić, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Stanojević, M.. (2003). An investigation into the influence of buffer media composition on drug release and in vitro - In vivo correlation for Carbopol 71G matrix tablets. in Farmacevtski Vestnik
Slovenian Pharmaceutical Society., 54(SPEC. ISS.), 355-356.
https://hdl.handle.net/21.15107/rcub_farfar_474

Parojčić J, Đurić Z, Jovanović M, Ibrić S, Stanojević M. An investigation into the influence of buffer media composition on drug release and in vitro - In vivo correlation for Carbopol 71G matrix tablets. in Farmacevtski Vestnik. 2003;54(SPEC. ISS.):355-356.
https://hdl.handle.net/21.15107/rcub_farfar_474 .

Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Stanojević, M, "An investigation into the influence of buffer media composition on drug release and in vitro - In vivo correlation for Carbopol 71G matrix tablets" in Farmacevtski Vestnik, 54, no. SPEC. ISS. (2003):355-356,
https://hdl.handle.net/21.15107/rcub_farfar_474 .

TY  - JOUR
AU  - Ibrić, Svetlana
AU  - Jovanović, M
AU  - Đurić, Zorica
AU  - Parojčić, Jelena
AU  - Petrović, Slobodan D.
AU  - Solomun, Ljiljana
AU  - Stupar, Biljana
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/469
AB  - The purpose of the present study was to model the effects of the concentration of Eudragit L 100 and compression pressure as the most important process and formulation variables on the in vitro release profile of aspirin from matrix tablets formulated with Eudragit L 100 as matrix substance and to optimize the formulation by artificial neural network. As model formulations, 10 kinds of aspirin matrix tablets were prepared. The amount of Eudragit L 100 and the compression pressure were selected as causal factors. In vitro dissolution time profiles at 4 different sampling times were chosen as responses. A set of release parameters and causal factors were used as tutorial data for the generalized regression neural network (GRNN) and analyzed using a computer. Observed results of drug release studies indicate that drug release rates vary widely between investigated formulations, with a range of 5 hours to more than 10 hours to complete dissolution. The GRNN model was optimized. The root mean square value for the trained network was 1.12%, which indicated that the optimal GRNN model was reached. Applying the generalized distance function method, the optimal tablet formulation predicted by GRNN was with 5% of Eudragit L 100 and tablet hardness 60N. Calculated difference (f1 2.465) and similarity (f2 85.61) factors indicate that there is no difference between predicted and experimentally observed drug release profiles for the optimal formulation. This work illustrates the potential for an artificial neural network, GRNN, to assist in development of extended release dosage forms.
PB  - AAPS PharmSci Editorial Office
T2  - AAPS PharmSciTech
T1  - Artificial neural networks in the modeling and optimization of aspirin extended release tablets with Eudragit L 100 as matrix substance
VL  - 4
IS  - 1
DO  - 10.1208/pt040109
ER  - 

@article{
author = "Ibrić, Svetlana and Jovanović, M and Đurić, Zorica and Parojčić, Jelena and Petrović, Slobodan D. and Solomun, Ljiljana and Stupar, Biljana",
year = "2003",
abstract = "The purpose of the present study was to model the effects of the concentration of Eudragit L 100 and compression pressure as the most important process and formulation variables on the in vitro release profile of aspirin from matrix tablets formulated with Eudragit L 100 as matrix substance and to optimize the formulation by artificial neural network. As model formulations, 10 kinds of aspirin matrix tablets were prepared. The amount of Eudragit L 100 and the compression pressure were selected as causal factors. In vitro dissolution time profiles at 4 different sampling times were chosen as responses. A set of release parameters and causal factors were used as tutorial data for the generalized regression neural network (GRNN) and analyzed using a computer. Observed results of drug release studies indicate that drug release rates vary widely between investigated formulations, with a range of 5 hours to more than 10 hours to complete dissolution. The GRNN model was optimized. The root mean square value for the trained network was 1.12%, which indicated that the optimal GRNN model was reached. Applying the generalized distance function method, the optimal tablet formulation predicted by GRNN was with 5% of Eudragit L 100 and tablet hardness 60N. Calculated difference (f1 2.465) and similarity (f2 85.61) factors indicate that there is no difference between predicted and experimentally observed drug release profiles for the optimal formulation. This work illustrates the potential for an artificial neural network, GRNN, to assist in development of extended release dosage forms.",
publisher = "AAPS PharmSci Editorial Office",
journal = "AAPS PharmSciTech",
title = "Artificial neural networks in the modeling and optimization of aspirin extended release tablets with Eudragit L 100 as matrix substance",
volume = "4",
number = "1",
doi = "10.1208/pt040109"
}

Ibrić, S., Jovanović, M., Đurić, Z., Parojčić, J., Petrović, S. D., Solomun, L.,& Stupar, B.. (2003). Artificial neural networks in the modeling and optimization of aspirin extended release tablets with Eudragit L 100 as matrix substance. in AAPS PharmSciTech
AAPS PharmSci Editorial Office., 4(1).
https://doi.org/10.1208/pt040109

Ibrić S, Jovanović M, Đurić Z, Parojčić J, Petrović SD, Solomun L, Stupar B. Artificial neural networks in the modeling and optimization of aspirin extended release tablets with Eudragit L 100 as matrix substance. in AAPS PharmSciTech. 2003;4(1).
doi:10.1208/pt040109 .

Ibrić, Svetlana, Jovanović, M, Đurić, Zorica, Parojčić, Jelena, Petrović, Slobodan D., Solomun, Ljiljana, Stupar, Biljana, "Artificial neural networks in the modeling and optimization of aspirin extended release tablets with Eudragit L 100 as matrix substance" in AAPS PharmSciTech, 4, no. 1 (2003),
https://doi.org/10.1208/pt040109 . .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Karljiković-Rajić, Katarina
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/422
AB  - Paracetamol is a widely used nonsalicylate analgesic and antipyretic drug. The existing methods for the determination of paracetamol in biological fluids are mainly HPLC techniques, although there are some reported methods based on spectrophotometric determinations. However, all these methods involve some extraction or derivatisation procedures. In the present study the UV spectra of investigated samples were recorded over the wavelength range 220-400 nm (lambda step 0.21 nm; scan speed 60 nm/min) and second-order derivative spectra were calculated. Second-order derivative spectra of different blank urine samples displayed the presence of a zero-crossing point at 245-247 nm defined as lambda(zc). The zero-order absorption spectra of paracetamol in water displays maximum absorbance at 243 nm, while in second derivative spectra, a minimum peak at 246 nm was observed. Therefore, the application of zero-crossing technique to the second-derivative UV absorption spectrum should be useful for the determination of paracetamol using 2D(lambdazc). The proposed method enables determination of total paracetamol in urine directly and simply by reading the D-2(lambdazc) of the diluted samples. The obtained results were in good accordance with published data on cumulative urinary excretion after per oral administration of paracetamol obtained applying different spectrophotometric methods of determination. It could be useful for biopharmaceutical characterisation of drug products (monitoring of the levels of paracetamol in urine in bioavailability testing, for the evaluation of in vitro-in vivo correlation and screening of different formulations during drug product development). Copyright
PB  - John Wiley & Sons Ltd, Chichester
T2  - Biopharmaceutics & Drug Disposition
T1  - Development of the second-order derivative UV spectrophotometric method for direct determination of paracetamol in urine intended for biopharmaceutical characterisation of drug products
VL  - 24
IS  - 7
SP  - 309
EP  - 314
DO  - 10.1002/bdd.367
ER  - 

@article{
author = "Parojčić, Jelena and Karljiković-Rajić, Katarina and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana",
year = "2003",
abstract = "Paracetamol is a widely used nonsalicylate analgesic and antipyretic drug. The existing methods for the determination of paracetamol in biological fluids are mainly HPLC techniques, although there are some reported methods based on spectrophotometric determinations. However, all these methods involve some extraction or derivatisation procedures. In the present study the UV spectra of investigated samples were recorded over the wavelength range 220-400 nm (lambda step 0.21 nm; scan speed 60 nm/min) and second-order derivative spectra were calculated. Second-order derivative spectra of different blank urine samples displayed the presence of a zero-crossing point at 245-247 nm defined as lambda(zc). The zero-order absorption spectra of paracetamol in water displays maximum absorbance at 243 nm, while in second derivative spectra, a minimum peak at 246 nm was observed. Therefore, the application of zero-crossing technique to the second-derivative UV absorption spectrum should be useful for the determination of paracetamol using 2D(lambdazc). The proposed method enables determination of total paracetamol in urine directly and simply by reading the D-2(lambdazc) of the diluted samples. The obtained results were in good accordance with published data on cumulative urinary excretion after per oral administration of paracetamol obtained applying different spectrophotometric methods of determination. It could be useful for biopharmaceutical characterisation of drug products (monitoring of the levels of paracetamol in urine in bioavailability testing, for the evaluation of in vitro-in vivo correlation and screening of different formulations during drug product development). Copyright",
publisher = "John Wiley & Sons Ltd, Chichester",
journal = "Biopharmaceutics & Drug Disposition",
title = "Development of the second-order derivative UV spectrophotometric method for direct determination of paracetamol in urine intended for biopharmaceutical characterisation of drug products",
volume = "24",
number = "7",
pages = "309-314",
doi = "10.1002/bdd.367"
}

Parojčić, J., Karljiković-Rajić, K., Đurić, Z., Jovanović, M.,& Ibrić, S.. (2003). Development of the second-order derivative UV spectrophotometric method for direct determination of paracetamol in urine intended for biopharmaceutical characterisation of drug products. in Biopharmaceutics & Drug Disposition
John Wiley & Sons Ltd, Chichester., 24(7), 309-314.
https://doi.org/10.1002/bdd.367

Parojčić J, Karljiković-Rajić K, Đurić Z, Jovanović M, Ibrić S. Development of the second-order derivative UV spectrophotometric method for direct determination of paracetamol in urine intended for biopharmaceutical characterisation of drug products. in Biopharmaceutics & Drug Disposition. 2003;24(7):309-314.
doi:10.1002/bdd.367 .

Parojčić, Jelena, Karljiković-Rajić, Katarina, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, "Development of the second-order derivative UV spectrophotometric method for direct determination of paracetamol in urine intended for biopharmaceutical characterisation of drug products" in Biopharmaceutics & Drug Disposition, 24, no. 7 (2003):309-314,
https://doi.org/10.1002/bdd.367 . .

TY  - CONF
AU  - Solomun, Ljiljana
AU  - Cvetićanin-Ilić, S.
AU  - Stupar, Biljana
AU  - Aćimović, D.
AU  - Jovanović, M.
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/409
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Photostability of drugs - nifedipine
T1  - Fotostabilnost lekova - nifedipin
VL  - 52
IS  - 4
SP  - 538
EP  - 539
UR  - https://hdl.handle.net/21.15107/rcub_farfar_409
ER  - 

@conference{
author = "Solomun, Ljiljana and Cvetićanin-Ilić, S. and Stupar, Biljana and Aćimović, D. and Jovanović, M.",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Photostability of drugs - nifedipine, Fotostabilnost lekova - nifedipin",
volume = "52",
number = "4",
pages = "538-539",
url = "https://hdl.handle.net/21.15107/rcub_farfar_409"
}

Solomun, L., Cvetićanin-Ilić, S., Stupar, B., Aćimović, D.,& Jovanović, M.. (2002). Photostability of drugs - nifedipine. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 538-539.
https://hdl.handle.net/21.15107/rcub_farfar_409

Solomun L, Cvetićanin-Ilić S, Stupar B, Aćimović D, Jovanović M. Photostability of drugs - nifedipine. in Arhiv za farmaciju. 2002;52(4):538-539.
https://hdl.handle.net/21.15107/rcub_farfar_409 .

Solomun, Ljiljana, Cvetićanin-Ilić, S., Stupar, Biljana, Aćimović, D., Jovanović, M., "Photostability of drugs - nifedipine" in Arhiv za farmaciju, 52, no. 4 (2002):538-539,
https://hdl.handle.net/21.15107/rcub_farfar_409 .

TY  - JOUR
AU  - Ibrić, Svetlana
AU  - Jovanović, M
AU  - Đurić, Zorica
AU  - Parojčić, Jelena
AU  - Solomun, Ljiljana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/321
AB  - The objective of this work is to use a generalized regression neural network (GRNN) in the design of extended-release aspirin tablets. As model formulations, 10 kinds of aspirin matrix tablets were prepared. Eudragit((R)) RS PO was used as matrix substance. The amount of Eudragit((R)) RS PO and compression pressure were selected as causal factors. In-vitro dissolution-time profiles at four different sampling times, as well as coefficients n (release order) and log k (release constant) from the Peppas equation were estimated as release parameters. A set of release parameters and causal factors were used as tutorial data for the GRNN and analyzing using a computer. A GRNN model was constructed. The optimized GRNN model was used for prediction of formulation with desired in vitro drug release. For two tested formulations there was very good agreement between the GRNN predicted and observed in vitro profiles and estimated coefficients. Calculated difference (f(1)) and similarity (f(2)) factors indicate that there is no difference between predicted and experimental observed drug release profiles. This work illustrates the potential for an artificial neural network, GRNN, to assist in development of extended-release dosage forms. This method can be employed to achieve a desired in vitro dissolution profile.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Controlled Release
T1  - The application of generalized regression neural network in the modeling and optimization of aspirin extended release tablets with Eudragit (R) RS PO as matrix substance
VL  - 82
IS  - 2-3
SP  - 213
EP  - 222
DO  - 10.1016/S0168-3659(02)00044-5
ER  - 

@article{
author = "Ibrić, Svetlana and Jovanović, M and Đurić, Zorica and Parojčić, Jelena and Solomun, Ljiljana",
year = "2002",
abstract = "The objective of this work is to use a generalized regression neural network (GRNN) in the design of extended-release aspirin tablets. As model formulations, 10 kinds of aspirin matrix tablets were prepared. Eudragit((R)) RS PO was used as matrix substance. The amount of Eudragit((R)) RS PO and compression pressure were selected as causal factors. In-vitro dissolution-time profiles at four different sampling times, as well as coefficients n (release order) and log k (release constant) from the Peppas equation were estimated as release parameters. A set of release parameters and causal factors were used as tutorial data for the GRNN and analyzing using a computer. A GRNN model was constructed. The optimized GRNN model was used for prediction of formulation with desired in vitro drug release. For two tested formulations there was very good agreement between the GRNN predicted and observed in vitro profiles and estimated coefficients. Calculated difference (f(1)) and similarity (f(2)) factors indicate that there is no difference between predicted and experimental observed drug release profiles. This work illustrates the potential for an artificial neural network, GRNN, to assist in development of extended-release dosage forms. This method can be employed to achieve a desired in vitro dissolution profile.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Controlled Release",
title = "The application of generalized regression neural network in the modeling and optimization of aspirin extended release tablets with Eudragit (R) RS PO as matrix substance",
volume = "82",
number = "2-3",
pages = "213-222",
doi = "10.1016/S0168-3659(02)00044-5"
}

Ibrić, S., Jovanović, M., Đurić, Z., Parojčić, J.,& Solomun, L.. (2002). The application of generalized regression neural network in the modeling and optimization of aspirin extended release tablets with Eudragit (R) RS PO as matrix substance. in Journal of Controlled Release
Elsevier Science BV, Amsterdam., 82(2-3), 213-222.
https://doi.org/10.1016/S0168-3659(02)00044-5

Ibrić S, Jovanović M, Đurić Z, Parojčić J, Solomun L. The application of generalized regression neural network in the modeling and optimization of aspirin extended release tablets with Eudragit (R) RS PO as matrix substance. in Journal of Controlled Release. 2002;82(2-3):213-222.
doi:10.1016/S0168-3659(02)00044-5 .

Ibrić, Svetlana, Jovanović, M, Đurić, Zorica, Parojčić, Jelena, Solomun, Ljiljana, "The application of generalized regression neural network in the modeling and optimization of aspirin extended release tablets with Eudragit (R) RS PO as matrix substance" in Journal of Controlled Release, 82, no. 2-3 (2002):213-222,
https://doi.org/10.1016/S0168-3659(02)00044-5 . .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Nikolić, L
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/304
AB  - Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.
PB  - Editio Cantor Verlag GmbH
T2  - Drugs Made in Germany
T1  - Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design
VL  - 44
IS  - 1
SP  - 19
EP  - 24
UR  - https://hdl.handle.net/21.15107/rcub_farfar_304
ER  - 

@article{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Nikolić, L",
year = "2001",
abstract = "Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results indicated that factorially designed experiments present a valuable tool in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.",
publisher = "Editio Cantor Verlag GmbH",
journal = "Drugs Made in Germany",
title = "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design",
volume = "44",
number = "1",
pages = "19-24",
url = "https://hdl.handle.net/21.15107/rcub_farfar_304"
}

Parojčić, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Nikolić, L.. (2001). Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Drugs Made in Germany
Editio Cantor Verlag GmbH., 44(1), 19-24.
https://hdl.handle.net/21.15107/rcub_farfar_304

Parojčić J, Đurić Z, Jovanović M, Ibrić S, Nikolić L. Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Drugs Made in Germany. 2001;44(1):19-24.
https://hdl.handle.net/21.15107/rcub_farfar_304 .

Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Nikolić, L, "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design" in Drugs Made in Germany, 44, no. 1 (2001):19-24,
https://hdl.handle.net/21.15107/rcub_farfar_304 .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Nikolić, L
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/284
AB  - Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most Important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results Indicated that factorially designed experiments present a valuable toot in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.
PB  - ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf
T2  - Pharmazeutische Industrie
T1  - Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design
VL  - 63
IS  - 7
SP  - 774
EP  - 779
UR  - https://hdl.handle.net/21.15107/rcub_farfar_284
ER  - 

@article{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Nikolić, L",
year = "2001",
abstract = "Dissolution rate of a drug substance can be strongly influenced by the experimental conditions employed, among which agitation intensity and pH value were recognized as the most Important. A complete two-factor, three-level factorial design followed by multiple regression analysis was applied in order to investigate the influence of pH and agitation intensity on paracetamol (CAS 103-90-2) and acetylsalicylic acid (CAS 50-78-2) dissolution from conventional tablets. Mean dissolution time, amount of drug dissolved after 30 min and first-order dissolution rate constant were evaluated as response variables in terms of their applicability to characterize different release profiles. The obtained results Indicated that factorially designed experiments present a valuable toot in dissolution method development. Mean dissolution time showed to be the most useful response criterion capable to differentiate between dissolution curves of different shape.",
publisher = "ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf",
journal = "Pharmazeutische Industrie",
title = "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design",
volume = "63",
number = "7",
pages = "774-779",
url = "https://hdl.handle.net/21.15107/rcub_farfar_284"
}

Parojčić, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Nikolić, L.. (2001). Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Pharmazeutische Industrie
ECV-Editio Cantor Verlag Medizin Naturwissenschaften, Aulendorf., 63(7), 774-779.
https://hdl.handle.net/21.15107/rcub_farfar_284

Parojčić J, Đurić Z, Jovanović M, Ibrić S, Nikolić L. Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design. in Pharmazeutische Industrie. 2001;63(7):774-779.
https://hdl.handle.net/21.15107/rcub_farfar_284 .

Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Nikolić, L, "Influence of pH and agitation intensity on drug dissolution from tablets evaluated by means of factorial design" in Pharmazeutische Industrie, 63, no. 7 (2001):774-779,
https://hdl.handle.net/21.15107/rcub_farfar_284 .

TY  - JOUR
AU  - Dukić, M
AU  - Jovanović, M
AU  - Nedeljković, M
AU  - Ignjatović, Svetlana
AU  - Antonijević, Biljana
PY  - 1999
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/226
AB  - Determination of gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities are two of the most recently used biochemical parameters in diagnosis of alcoholism and heavy drinking. We examined the effect of a two-week disulfiram (DSF) treatment on GGT and ALP activities in alcoholic volunteers. The trial lasted 21 days and it was conducted on ten moderate hospitalized alcoholics. During the first two experimental weeks the alcoholics received repeated oral doses of 500 mg DSF/day, and the last week was DSF free. Activities of both enzymes significantly decreased during the two-week DSF treatment. The calculated GGT/ALP ratio continually increased during the therapy, while it was enormously increased one-week after DSF therapy.
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics
VL  - 18
IS  - 4
SP  - 161
EP  - 165
UR  - https://hdl.handle.net/21.15107/rcub_farfar_226
ER  - 

@article{
author = "Dukić, M and Jovanović, M and Nedeljković, M and Ignjatović, Svetlana and Antonijević, Biljana",
year = "1999",
abstract = "Determination of gamma-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities are two of the most recently used biochemical parameters in diagnosis of alcoholism and heavy drinking. We examined the effect of a two-week disulfiram (DSF) treatment on GGT and ALP activities in alcoholic volunteers. The trial lasted 21 days and it was conducted on ten moderate hospitalized alcoholics. During the first two experimental weeks the alcoholics received repeated oral doses of 500 mg DSF/day, and the last week was DSF free. Activities of both enzymes significantly decreased during the two-week DSF treatment. The calculated GGT/ALP ratio continually increased during the therapy, while it was enormously increased one-week after DSF therapy.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics",
volume = "18",
number = "4",
pages = "161-165",
url = "https://hdl.handle.net/21.15107/rcub_farfar_226"
}

Dukić, M., Jovanović, M., Nedeljković, M., Ignjatović, S.,& Antonijević, B.. (1999). Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 18(4), 161-165.
https://hdl.handle.net/21.15107/rcub_farfar_226

Dukić M, Jovanović M, Nedeljković M, Ignjatović S, Antonijević B. Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics. in Jugoslovenska medicinska biohemija. 1999;18(4):161-165.
https://hdl.handle.net/21.15107/rcub_farfar_226 .

Dukić, M, Jovanović, M, Nedeljković, M, Ignjatović, Svetlana, Antonijević, Biljana, "Influence on a two-week disulfiram treatment on GGT and ALP activities in alcoholics" in Jugoslovenska medicinska biohemija, 18, no. 4 (1999):161-165,
https://hdl.handle.net/21.15107/rcub_farfar_226 .

TY  - JOUR
AU  - Radovanović, J
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Petrović, M
PY  - 1998
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/185
AB  - The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution media was investigated. The level B approach, using statistical moment analysis led to poor correlation results. The results obtained by numerical deconvolution in order to study level A correlation indicated that good correlation should be sought with moderate levels of agitation (beyond 50 rpm in rotating basket apparatus). Results obtained by numerical convolution showed the highest level of correlation, level A, with one-to-one relationship between observed and predicted in vivo profiles.
PB  - Medecine Et Hygiene, Geneva 4
T2  - European Journal of Drug Metabolism and Pharmacokinetics
T1  - An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets
VL  - 23
IS  - 1
SP  - 33
EP  - 40
DO  - 10.1007/BF03189824
ER  - 

@article{
author = "Radovanović, J and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Petrović, M",
year = "1998",
abstract = "The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution media was investigated. The level B approach, using statistical moment analysis led to poor correlation results. The results obtained by numerical deconvolution in order to study level A correlation indicated that good correlation should be sought with moderate levels of agitation (beyond 50 rpm in rotating basket apparatus). Results obtained by numerical convolution showed the highest level of correlation, level A, with one-to-one relationship between observed and predicted in vivo profiles.",
publisher = "Medecine Et Hygiene, Geneva 4",
journal = "European Journal of Drug Metabolism and Pharmacokinetics",
title = "An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets",
volume = "23",
number = "1",
pages = "33-40",
doi = "10.1007/BF03189824"
}

Radovanović, J., Đurić, Z., Jovanović, M., Ibrić, S.,& Petrović, M.. (1998). An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets. in European Journal of Drug Metabolism and Pharmacokinetics
Medecine Et Hygiene, Geneva 4., 23(1), 33-40.
https://doi.org/10.1007/BF03189824

Radovanović J, Đurić Z, Jovanović M, Ibrić S, Petrović M. An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets. in European Journal of Drug Metabolism and Pharmacokinetics. 1998;23(1):33-40.
doi:10.1007/BF03189824 .

Radovanović, J, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Petrović, M, "An attempt to establish an in vitro in vivo correlation: case of paracetamol immediate-release tablets" in European Journal of Drug Metabolism and Pharmacokinetics, 23, no. 1 (1998):33-40,
https://doi.org/10.1007/BF03189824 . .

TY  - JOUR
AU  - Jovanović, M
AU  - Jovicić, G
AU  - Đurić, Zorica
AU  - Agbaba, Danica
AU  - Karljiković-Rajić, Katarina
AU  - Radovanović, J
AU  - Nikolić, L
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/161
AB  - The effect of fillers and lubricants on the dissolution rate of acetylsalicylic acid (ASA) from matrix tablets has been evaluated. Eudragit S-100 and Eudragit L-100-55 where chosen as matrix substances. The process of drug release in vitro was studied by the modified half-change method. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. Differences in release rate of ASA from matrix tablets, regarding the diluents used, appeared to be more significant when matrices contained Eudragit L-100-55 as compared to Eudragit S-100. The highest dissolution rates of ASA were observed in the presence of Lubritab as lubricant. The other lubricants used showed similar effects on the release rate of ASA. The release of ASA from samples containing Eudragit L-100-55 corresponded best to the zero-order kinetics. The best-fitted model for the ASA release from tablets prepared with Eudragit S-100 was obtained by using the Hixson-Crowell equation.
PB  - Marcel Dekker Inc, New York
T2  - Drug Development and Industrial Pharmacy
T1  - Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets
VL  - 23
IS  - 6
SP  - 595
EP  - 602
DO  - 10.3109/03639049709149825
ER  - 

@article{
author = "Jovanović, M and Jovicić, G and Đurić, Zorica and Agbaba, Danica and Karljiković-Rajić, Katarina and Radovanović, J and Nikolić, L",
year = "1997",
abstract = "The effect of fillers and lubricants on the dissolution rate of acetylsalicylic acid (ASA) from matrix tablets has been evaluated. Eudragit S-100 and Eudragit L-100-55 where chosen as matrix substances. The process of drug release in vitro was studied by the modified half-change method. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. Differences in release rate of ASA from matrix tablets, regarding the diluents used, appeared to be more significant when matrices contained Eudragit L-100-55 as compared to Eudragit S-100. The highest dissolution rates of ASA were observed in the presence of Lubritab as lubricant. The other lubricants used showed similar effects on the release rate of ASA. The release of ASA from samples containing Eudragit L-100-55 corresponded best to the zero-order kinetics. The best-fitted model for the ASA release from tablets prepared with Eudragit S-100 was obtained by using the Hixson-Crowell equation.",
publisher = "Marcel Dekker Inc, New York",
journal = "Drug Development and Industrial Pharmacy",
title = "Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets",
volume = "23",
number = "6",
pages = "595-602",
doi = "10.3109/03639049709149825"
}

Jovanović, M., Jovicić, G., Đurić, Z., Agbaba, D., Karljiković-Rajić, K., Radovanović, J.,& Nikolić, L.. (1997). Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets. in Drug Development and Industrial Pharmacy
Marcel Dekker Inc, New York., 23(6), 595-602.
https://doi.org/10.3109/03639049709149825

Jovanović M, Jovicić G, Đurić Z, Agbaba D, Karljiković-Rajić K, Radovanović J, Nikolić L. Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets. in Drug Development and Industrial Pharmacy. 1997;23(6):595-602.
doi:10.3109/03639049709149825 .

Jovanović, M, Jovicić, G, Đurić, Zorica, Agbaba, Danica, Karljiković-Rajić, Katarina, Radovanović, J, Nikolić, L, "Effect of fillers and lubricants on acetylsalicylic acid release kinetics from Eudragit matrix tablets" in Drug Development and Industrial Pharmacy, 23, no. 6 (1997):595-602,
https://doi.org/10.3109/03639049709149825 . .