TY  - JOUR
AU  - Kovačević, Tijana
AU  - Miljković, Branislava
AU  - Mikov, Momir
AU  - Stojisavljević-Satara, Svjetlana
AU  - Dragić, Sasa
AU  - Momcicević, Danica
AU  - Kovacević, Peđa
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3345
AB  - Purpose: To determine whether severe hypoalbuminemia ( lt 25 mg/L) has a significant effect on serum levels of vancomycin and whether it can effect vancomycin dosage regimen and the loading dose administration. Material and Methods: Prospective, cohort, and a single-center study included 61 patients whose vancomycin serum levels were measured in steady state. Vancomycin trough levels (C-min) that were in the range 15 to 20 mu g/mL were considered therapeutic and trough levels higher than 15 mu g/mL were considered potentially nephrotoxic. Results: In the group of patients with severe hypoalbuminemia, C-min was significantly higher compared to the those with nonsevere hypoalbuminemia (>25 mg/L; 23.04 [19.14] vs 13.28 [11.28], P = .01). In the group of patients who received the vancomycin loading dose of 2 g, C-min was significantly higher in patients with severe hypoalbuminemia compared to the patients with nonsevere hypoalbuminemia (34.52 [25.93] vs 15.37 [10.48], P = .04). Conclusion: In critically ill septic patients with severe hypoalbuminemia, there is a high probability that the loading dose of vancomycin is not necessary since it is associated with potentially toxic vancomycin C-min, while in the patients with nonsevere hypoalbuminemia the loading dose may be necessary to achieving therapeutic C-min.
PB  - Sage Publications Inc, Thousand Oaks
T2  - Dose-Response
T1  - The Effect of Hypoalbuminemia on the Therapeutic Concentration and Dosage of Vancomycin in Critically Ill Septic Patients in Low-Resource Countries
VL  - 17
IS  - 2
DO  - 10.1177/1559325819850419
ER  - 

@article{
author = "Kovačević, Tijana and Miljković, Branislava and Mikov, Momir and Stojisavljević-Satara, Svjetlana and Dragić, Sasa and Momcicević, Danica and Kovacević, Peđa",
year = "2019",
abstract = "Purpose: To determine whether severe hypoalbuminemia ( lt 25 mg/L) has a significant effect on serum levels of vancomycin and whether it can effect vancomycin dosage regimen and the loading dose administration. Material and Methods: Prospective, cohort, and a single-center study included 61 patients whose vancomycin serum levels were measured in steady state. Vancomycin trough levels (C-min) that were in the range 15 to 20 mu g/mL were considered therapeutic and trough levels higher than 15 mu g/mL were considered potentially nephrotoxic. Results: In the group of patients with severe hypoalbuminemia, C-min was significantly higher compared to the those with nonsevere hypoalbuminemia (>25 mg/L; 23.04 [19.14] vs 13.28 [11.28], P = .01). In the group of patients who received the vancomycin loading dose of 2 g, C-min was significantly higher in patients with severe hypoalbuminemia compared to the patients with nonsevere hypoalbuminemia (34.52 [25.93] vs 15.37 [10.48], P = .04). Conclusion: In critically ill septic patients with severe hypoalbuminemia, there is a high probability that the loading dose of vancomycin is not necessary since it is associated with potentially toxic vancomycin C-min, while in the patients with nonsevere hypoalbuminemia the loading dose may be necessary to achieving therapeutic C-min.",
publisher = "Sage Publications Inc, Thousand Oaks",
journal = "Dose-Response",
title = "The Effect of Hypoalbuminemia on the Therapeutic Concentration and Dosage of Vancomycin in Critically Ill Septic Patients in Low-Resource Countries",
volume = "17",
number = "2",
doi = "10.1177/1559325819850419"
}

Kovačević, T., Miljković, B., Mikov, M., Stojisavljević-Satara, S., Dragić, S., Momcicević, D.,& Kovacević, P.. (2019). The Effect of Hypoalbuminemia on the Therapeutic Concentration and Dosage of Vancomycin in Critically Ill Septic Patients in Low-Resource Countries. in Dose-Response
Sage Publications Inc, Thousand Oaks., 17(2).
https://doi.org/10.1177/1559325819850419

Kovačević T, Miljković B, Mikov M, Stojisavljević-Satara S, Dragić S, Momcicević D, Kovacević P. The Effect of Hypoalbuminemia on the Therapeutic Concentration and Dosage of Vancomycin in Critically Ill Septic Patients in Low-Resource Countries. in Dose-Response. 2019;17(2).
doi:10.1177/1559325819850419 .

Kovačević, Tijana, Miljković, Branislava, Mikov, Momir, Stojisavljević-Satara, Svjetlana, Dragić, Sasa, Momcicević, Danica, Kovacević, Peđa, "The Effect of Hypoalbuminemia on the Therapeutic Concentration and Dosage of Vancomycin in Critically Ill Septic Patients in Low-Resource Countries" in Dose-Response, 17, no. 2 (2019),
https://doi.org/10.1177/1559325819850419 . .