TY  - JOUR
AU  - Vekić, Jelena
AU  - Vujčić, Sanja
AU  - Bufan, Biljana
AU  - Bojanin, Dragana
AU  - Al-Hashmi, Khamis
AU  - Al-Rasadi, Khaild
AU  - Stoian, Anca Pantea
AU  - Zeljković, Aleksandra
AU  - Rizzo, Manfredi
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4415
AB  - Disorders of lipoprotein metabolism and glucose homeostasis are common consequences of insulin resistance and usually co-segregate in patients with metabolic syndrome and type 2 diabetes mellitus (DM). Insulin-resistant subjects are characterized by atherogenic dyslipidemia, a specific lipid pattern which includes hypertriglyceridemia, reduced high-density lipoprotein cholesterol level, and increased proportion of small, dense low-density lipoprotein (LDL). Chronic hyperglycemia favors the processes of non-enzymatic glycation, leading to the increased production of advanced glycation end products (AGEs). Apart from direct harmful effects, AGEs are also potent inducers of oxidative stress and inflammation. In addition, increased AGEs’ production may induce further qualitative modifications of small, dense LDL particles, converting them to glycated LDLs. These particles are even more atherogenic and may confer an increased cardiovascular risk. In this narrative review, we summarize the available evidence of the pathophysiological role and clinical importance of circulating AGEs and glycated LDLs in patients with dyslipidemia, particularly those with DM and related complications. In addition, we discuss recent advances and the issues that should be improved regarding laboratory assessment of AGEs and glycated LDLs, as well as the possibilities for their therapeutic modulation.
PB  - MDPI
T2  - Metabolites
T1  - The Role of Advanced Glycation End Products on Dyslipidemia
VL  - 13
IS  - 1
DO  - 10.3390/metabo13010077
ER  - 

@article{
author = "Vekić, Jelena and Vujčić, Sanja and Bufan, Biljana and Bojanin, Dragana and Al-Hashmi, Khamis and Al-Rasadi, Khaild and Stoian, Anca Pantea and Zeljković, Aleksandra and Rizzo, Manfredi",
year = "2023",
abstract = "Disorders of lipoprotein metabolism and glucose homeostasis are common consequences of insulin resistance and usually co-segregate in patients with metabolic syndrome and type 2 diabetes mellitus (DM). Insulin-resistant subjects are characterized by atherogenic dyslipidemia, a specific lipid pattern which includes hypertriglyceridemia, reduced high-density lipoprotein cholesterol level, and increased proportion of small, dense low-density lipoprotein (LDL). Chronic hyperglycemia favors the processes of non-enzymatic glycation, leading to the increased production of advanced glycation end products (AGEs). Apart from direct harmful effects, AGEs are also potent inducers of oxidative stress and inflammation. In addition, increased AGEs’ production may induce further qualitative modifications of small, dense LDL particles, converting them to glycated LDLs. These particles are even more atherogenic and may confer an increased cardiovascular risk. In this narrative review, we summarize the available evidence of the pathophysiological role and clinical importance of circulating AGEs and glycated LDLs in patients with dyslipidemia, particularly those with DM and related complications. In addition, we discuss recent advances and the issues that should be improved regarding laboratory assessment of AGEs and glycated LDLs, as well as the possibilities for their therapeutic modulation.",
publisher = "MDPI",
journal = "Metabolites",
title = "The Role of Advanced Glycation End Products on Dyslipidemia",
volume = "13",
number = "1",
doi = "10.3390/metabo13010077"
}

Vekić, J., Vujčić, S., Bufan, B., Bojanin, D., Al-Hashmi, K., Al-Rasadi, K., Stoian, A. P., Zeljković, A.,& Rizzo, M.. (2023). The Role of Advanced Glycation End Products on Dyslipidemia. in Metabolites
MDPI., 13(1).
https://doi.org/10.3390/metabo13010077

Vekić J, Vujčić S, Bufan B, Bojanin D, Al-Hashmi K, Al-Rasadi K, Stoian AP, Zeljković A, Rizzo M. The Role of Advanced Glycation End Products on Dyslipidemia. in Metabolites. 2023;13(1).
doi:10.3390/metabo13010077 .

Vekić, Jelena, Vujčić, Sanja, Bufan, Biljana, Bojanin, Dragana, Al-Hashmi, Khamis, Al-Rasadi, Khaild, Stoian, Anca Pantea, Zeljković, Aleksandra, Rizzo, Manfredi, "The Role of Advanced Glycation End Products on Dyslipidemia" in Metabolites, 13, no. 1 (2023),
https://doi.org/10.3390/metabo13010077 . .

TY  - JOUR
AU  - Sopić, Miron
AU  - Ninić, Ana
AU  - Ostanek, Barbara
AU  - Bojanin, Dragana
AU  - Milenković, Tatjana
AU  - Munjas, Jelena
AU  - Mihajlović, Marija
AU  - Vekić, Jelena
AU  - Marc, Janja
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4255
AB  - Background: Type 1 diabetes mellitus (T1DM) is one of the
most common endocrine diseases in children. T-cell autore-
activity toward b-cells is controlled by significant changes in
metabolism of T cells. Mammalian target of rapamycin
(mTOR) is an important intracellular regulator of metabolism
and cell growth. MAPK/MAK/MRK overlapping kinase 1
(MOK1) is one of the less known regulators of mTOR. We
sought to investigate if MOK1 and mTOR mRNA levels in
peripheral blood mononuclear cells (PBMCs) of T1DM pedi-
atric patients are different compared to healthy subjects.
Methods: This study included 172 adolescents with T1DM
and 36 healthy adolescent volunteers designated for control
group (CG). MOK1 and mTOR mRNA levels were deter-
mined in PBMCs by qPCR.
Results: T1DM patients have significant downregulation of
MOK1 mRNA levels in PBMCs compared CG (P=0.018),
while there was no significant difference in mTOR mRNA
levels (P=0.891). Furthermore, in T1DM patients, MOK1
significantly correlated with age, triglycerides and mTOR,
while mTOR correlated significantly with BMI and systolic
blood pressure. Overweight T1DM subjects had significantly
lower MOK1 (P=0.034) and mTOR (P=0.017) mRNA
levels, together with significantly higher levels of systolic
blood pressure (P<0.001), total cholesterol (P=0.001),
LDL-cholesterol (P=0.001) and CRP (P<0.001). Multi-
variate analysis showed that MOK1 was independently
negatively associated with T1DM when adjusted for sex, age, HDL-C and CRP (OR=0.417 (95%CI: 0.175–0.997),
p=0.049).
Conclusions: Our study demonstrated for the first time that
T1DM is associated with MOK1 downregulation. In addition,
downregulation of both mTOR and MOK1 gene expressions
was associated with cardiovascular risk factors in overweight
T1DM patients.
AB  - Uvod: Dijabetes melitus tip 1 (T1DM) jedno je od najčešćih endokrinih oboljenja kod dece. Autoreaktivnost T-ćelija prema b-ćelijama kontroliše se značajnim promenama u metabolizmu T ćelija. Cilj delovanja rapamicina kod sisara je važan unutarćelijski regulator metabolizma i rasta ćelija. MAPK/MAK/MRK preklapajuće kinaze koja se preklapa (MOK1) jedan je od manje poznatih regulatora mTOR-a. Cilj istraživanja je bio da se ispita da li su nivoi iRNK MOK1 i mTOR u mononuklearnim ćelijama periferne krvi različiti kod pedijatrijskih pacijenata sa T1DM u odnosu na zdrave ispitanike. Metode: Ovo istraživanje je obuhvatilo 172 adolescenta sa T1DM i 36 zdravih adolescenata dobrovoljaca koji su činili kontrolnu grupu (CG). Nivoi MOK1 i mTOR mRNA određeni su u PBMC-ima pomoću qPCR-a. Rezultati: Pacijenti sa T1DM imali su značajno niže nivoe iRNK MOK1 u PBMC u odnosu na CG, dok razlike u nivoima iRNK mTOR nisu bile značajne (P = 0,891). Štaviše, kod pacijenata sa T1DM, MOK1 je značajno korelirao sa godinama, trigliceri dima i mTOR, dok je mTOR značajno korelirao sa BMI i sistolnim krvnim pritiskom. Ispitanici sa prekomernom težinom T1DM imali su značajno niže nivoe iRNK MOK1 (P = 0,034) i mTOR (P = 0,017), zajedno sa značajno većim nivoima sistolnog krvnog pritiska (P <0,001), ukupnog holesterola (P = 0,001), LDL-holesterola (P = 0,001) i CRP (P <0,001). Multivarijantna analiza je pokazala da je MOK1 nezavisno negativno povezan sa T1DM kada je prilagođen polu, starosti, HDL-C i CRP (OR = 0,417 (95%CI: 0,175-0,997), p = 0,049). Zaključak: Naša studija je prva koja je pokazala da je T1DM udružen sa nishodnom regulacijom MOK1. Pored toga, snižena regulacija ekspresije gena mTOR i MOK1 bila je povezana sa kardiovaskularnim faktorima rizika kod pacije nata sa T1DM sa prekomernom težinom.
PB  - Beograd : Društvo medicinskih biohemičara Srbije
T2  - Journal of Medical Biochemistry
T1  - Downregulation of MAPK/MAK/MRK overlapping kinase 1 in peripheral blood mononuclear cells of pediatric patients with type 1 diabetes mellitus
T1  - Nishodna regulacija MAPK/MAK/MRK preklapajuće kinaze u mononuklearnim ćelijama periferne krvi pedijatrijskih pacijenata sa tip1 diiabetes mellitus-om
VL  - 41
IS  - 3
SP  - 282
EP  - 289
DO  - 10.5937/jomb0-33220
ER  - 

@article{
author = "Sopić, Miron and Ninić, Ana and Ostanek, Barbara and Bojanin, Dragana and Milenković, Tatjana and Munjas, Jelena and Mihajlović, Marija and Vekić, Jelena and Marc, Janja and Spasojević-Kalimanovska, Vesna",
year = "2022",
abstract = "Background: Type 1 diabetes mellitus (T1DM) is one of the
most common endocrine diseases in children. T-cell autore-
activity toward b-cells is controlled by significant changes in
metabolism of T cells. Mammalian target of rapamycin
(mTOR) is an important intracellular regulator of metabolism
and cell growth. MAPK/MAK/MRK overlapping kinase 1
(MOK1) is one of the less known regulators of mTOR. We
sought to investigate if MOK1 and mTOR mRNA levels in
peripheral blood mononuclear cells (PBMCs) of T1DM pedi-
atric patients are different compared to healthy subjects.
Methods: This study included 172 adolescents with T1DM
and 36 healthy adolescent volunteers designated for control
group (CG). MOK1 and mTOR mRNA levels were deter-
mined in PBMCs by qPCR.
Results: T1DM patients have significant downregulation of
MOK1 mRNA levels in PBMCs compared CG (P=0.018),
while there was no significant difference in mTOR mRNA
levels (P=0.891). Furthermore, in T1DM patients, MOK1
significantly correlated with age, triglycerides and mTOR,
while mTOR correlated significantly with BMI and systolic
blood pressure. Overweight T1DM subjects had significantly
lower MOK1 (P=0.034) and mTOR (P=0.017) mRNA
levels, together with significantly higher levels of systolic
blood pressure (P<0.001), total cholesterol (P=0.001),
LDL-cholesterol (P=0.001) and CRP (P<0.001). Multi-
variate analysis showed that MOK1 was independently
negatively associated with T1DM when adjusted for sex, age, HDL-C and CRP (OR=0.417 (95%CI: 0.175–0.997),
p=0.049).
Conclusions: Our study demonstrated for the first time that
T1DM is associated with MOK1 downregulation. In addition,
downregulation of both mTOR and MOK1 gene expressions
was associated with cardiovascular risk factors in overweight
T1DM patients., Uvod: Dijabetes melitus tip 1 (T1DM) jedno je od najčešćih endokrinih oboljenja kod dece. Autoreaktivnost T-ćelija prema b-ćelijama kontroliše se značajnim promenama u metabolizmu T ćelija. Cilj delovanja rapamicina kod sisara je važan unutarćelijski regulator metabolizma i rasta ćelija. MAPK/MAK/MRK preklapajuće kinaze koja se preklapa (MOK1) jedan je od manje poznatih regulatora mTOR-a. Cilj istraživanja je bio da se ispita da li su nivoi iRNK MOK1 i mTOR u mononuklearnim ćelijama periferne krvi različiti kod pedijatrijskih pacijenata sa T1DM u odnosu na zdrave ispitanike. Metode: Ovo istraživanje je obuhvatilo 172 adolescenta sa T1DM i 36 zdravih adolescenata dobrovoljaca koji su činili kontrolnu grupu (CG). Nivoi MOK1 i mTOR mRNA određeni su u PBMC-ima pomoću qPCR-a. Rezultati: Pacijenti sa T1DM imali su značajno niže nivoe iRNK MOK1 u PBMC u odnosu na CG, dok razlike u nivoima iRNK mTOR nisu bile značajne (P = 0,891). Štaviše, kod pacijenata sa T1DM, MOK1 je značajno korelirao sa godinama, trigliceri dima i mTOR, dok je mTOR značajno korelirao sa BMI i sistolnim krvnim pritiskom. Ispitanici sa prekomernom težinom T1DM imali su značajno niže nivoe iRNK MOK1 (P = 0,034) i mTOR (P = 0,017), zajedno sa značajno većim nivoima sistolnog krvnog pritiska (P <0,001), ukupnog holesterola (P = 0,001), LDL-holesterola (P = 0,001) i CRP (P <0,001). Multivarijantna analiza je pokazala da je MOK1 nezavisno negativno povezan sa T1DM kada je prilagođen polu, starosti, HDL-C i CRP (OR = 0,417 (95%CI: 0,175-0,997), p = 0,049). Zaključak: Naša studija je prva koja je pokazala da je T1DM udružen sa nishodnom regulacijom MOK1. Pored toga, snižena regulacija ekspresije gena mTOR i MOK1 bila je povezana sa kardiovaskularnim faktorima rizika kod pacije nata sa T1DM sa prekomernom težinom.",
publisher = "Beograd : Društvo medicinskih biohemičara Srbije",
journal = "Journal of Medical Biochemistry",
title = "Downregulation of MAPK/MAK/MRK overlapping kinase 1 in peripheral blood mononuclear cells of pediatric patients with type 1 diabetes mellitus, Nishodna regulacija MAPK/MAK/MRK preklapajuće kinaze u mononuklearnim ćelijama periferne krvi pedijatrijskih pacijenata sa tip1 diiabetes mellitus-om",
volume = "41",
number = "3",
pages = "282-289",
doi = "10.5937/jomb0-33220"
}

Sopić, M., Ninić, A., Ostanek, B., Bojanin, D., Milenković, T., Munjas, J., Mihajlović, M., Vekić, J., Marc, J.,& Spasojević-Kalimanovska, V.. (2022). Downregulation of MAPK/MAK/MRK overlapping kinase 1 in peripheral blood mononuclear cells of pediatric patients with type 1 diabetes mellitus. in Journal of Medical Biochemistry
Beograd : Društvo medicinskih biohemičara Srbije., 41(3), 282-289.
https://doi.org/10.5937/jomb0-33220

Sopić M, Ninić A, Ostanek B, Bojanin D, Milenković T, Munjas J, Mihajlović M, Vekić J, Marc J, Spasojević-Kalimanovska V. Downregulation of MAPK/MAK/MRK overlapping kinase 1 in peripheral blood mononuclear cells of pediatric patients with type 1 diabetes mellitus. in Journal of Medical Biochemistry. 2022;41(3):282-289.
doi:10.5937/jomb0-33220 .

Sopić, Miron, Ninić, Ana, Ostanek, Barbara, Bojanin, Dragana, Milenković, Tatjana, Munjas, Jelena, Mihajlović, Marija, Vekić, Jelena, Marc, Janja, Spasojević-Kalimanovska, Vesna, "Downregulation of MAPK/MAK/MRK overlapping kinase 1 in peripheral blood mononuclear cells of pediatric patients with type 1 diabetes mellitus" in Journal of Medical Biochemistry, 41, no. 3 (2022):282-289,
https://doi.org/10.5937/jomb0-33220 . .

TY  - JOUR
AU  - Perović-Blagojević, Iva
AU  - Bojanin, Dragana
AU  - Ristovski-Kornic, Danijela
AU  - Marković, Jelena
AU  - Aleksić, Predrag
AU  - Subošić, Branko
AU  - Vekić, Jelena
AU  - Kotur-Stevuljević, Jelena
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4190
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a highly
transmittable and heterogenic infection of the respiratory tract, characterized by a broad spectrum
of clinical manifestations with a different degree of severity. Medical laboratories play an
important role in early diagnosis and management of Coronavirus Disease 2019 (COVID-19)
patients. Indeed, the results of several laboratory tests are essential for assessing the severity of
the disease, selecting appropriate therapeutic procedures and monitoring treatment response.
Routine laboratory testing in COVID-19 patients includes biomarkers of acute phase reaction,
hematological and biochemical parameters that indicate tissue injury. The aim of this review
paper is to describe the role of these biomarkers in the diagnostics and management of adult and
pediatric COVID-19 patients.
AB  - Novi koronavirus SARS-CoV-2 je uzročnik lako prenosive i veoma heterogene infekcije respiratornog trakta, koju karakteriše širok spektar kliničkih manifestacija, različitog stepena težine. Medicinske laboratorije igraju važnu ulogu u ranoj dijagnostici i praćenju pacijenata sa COVID-19. Rezultati nekoliko laboratorijskih testova su od suštinskog značaja za procenu težine bolesti, odabir odgovarajućih terapijskih procedura i praćenje odgovora na terapiju. Rutinska laboratorijska ispitivanja kod pacijenata sa COVID-19 uključuju biomarkere akutne faze, hematološke i biohemijske parametre koji ukazuju na oštećenje tkiva. Cilj ovog rada je da se prikaže uloga tih biomarkera u dijagnostici i praćenju toka bolesti kod odraslih i pedijatrijskih pacijenata sa COVID-19.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - The role of laboratory biomarkers in diagnostics and management of COVID-19 patients
T1  - Uloga laboratorijskih biomarkera u dijagnostici i praćenju pacijenata sa COVID-19
VL  - 72
IS  - 2
SP  - 231
EP  - 246
DO  - 10.5937/arhfarm72-36369
ER  - 

@article{
author = "Perović-Blagojević, Iva and Bojanin, Dragana and Ristovski-Kornic, Danijela and Marković, Jelena and Aleksić, Predrag and Subošić, Branko and Vekić, Jelena and Kotur-Stevuljević, Jelena",
year = "2022",
abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a highly
transmittable and heterogenic infection of the respiratory tract, characterized by a broad spectrum
of clinical manifestations with a different degree of severity. Medical laboratories play an
important role in early diagnosis and management of Coronavirus Disease 2019 (COVID-19)
patients. Indeed, the results of several laboratory tests are essential for assessing the severity of
the disease, selecting appropriate therapeutic procedures and monitoring treatment response.
Routine laboratory testing in COVID-19 patients includes biomarkers of acute phase reaction,
hematological and biochemical parameters that indicate tissue injury. The aim of this review
paper is to describe the role of these biomarkers in the diagnostics and management of adult and
pediatric COVID-19 patients., Novi koronavirus SARS-CoV-2 je uzročnik lako prenosive i veoma heterogene infekcije respiratornog trakta, koju karakteriše širok spektar kliničkih manifestacija, različitog stepena težine. Medicinske laboratorije igraju važnu ulogu u ranoj dijagnostici i praćenju pacijenata sa COVID-19. Rezultati nekoliko laboratorijskih testova su od suštinskog značaja za procenu težine bolesti, odabir odgovarajućih terapijskih procedura i praćenje odgovora na terapiju. Rutinska laboratorijska ispitivanja kod pacijenata sa COVID-19 uključuju biomarkere akutne faze, hematološke i biohemijske parametre koji ukazuju na oštećenje tkiva. Cilj ovog rada je da se prikaže uloga tih biomarkera u dijagnostici i praćenju toka bolesti kod odraslih i pedijatrijskih pacijenata sa COVID-19.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "The role of laboratory biomarkers in diagnostics and management of COVID-19 patients, Uloga laboratorijskih biomarkera u dijagnostici i praćenju pacijenata sa COVID-19",
volume = "72",
number = "2",
pages = "231-246",
doi = "10.5937/arhfarm72-36369"
}

Perović-Blagojević, I., Bojanin, D., Ristovski-Kornic, D., Marković, J., Aleksić, P., Subošić, B., Vekić, J.,& Kotur-Stevuljević, J.. (2022). The role of laboratory biomarkers in diagnostics and management of COVID-19 patients. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 72(2), 231-246.
https://doi.org/10.5937/arhfarm72-36369

Perović-Blagojević I, Bojanin D, Ristovski-Kornic D, Marković J, Aleksić P, Subošić B, Vekić J, Kotur-Stevuljević J. The role of laboratory biomarkers in diagnostics and management of COVID-19 patients. in Arhiv za farmaciju. 2022;72(2):231-246.
doi:10.5937/arhfarm72-36369 .

Perović-Blagojević, Iva, Bojanin, Dragana, Ristovski-Kornic, Danijela, Marković, Jelena, Aleksić, Predrag, Subošić, Branko, Vekić, Jelena, Kotur-Stevuljević, Jelena, "The role of laboratory biomarkers in diagnostics and management of COVID-19 patients" in Arhiv za farmaciju, 72, no. 2 (2022):231-246,
https://doi.org/10.5937/arhfarm72-36369 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Jorgovanović, Dragica
AU  - Bojanin, Dragana
AU  - Radovanović, Jelena
AU  - Gojković, Tamara
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Mandinić, Zoran
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3916
AB  - Linkage between bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA) coexposure and type 2 diabetes mellitus (T2DM), as well as ability of multi-strained probiotic to reduce DEHP, DBP and BPA mixture-induced oxidative damage in rat pancreas were investigated. The Comparative Toxicogenomics Database, Cytoscape software and ToppGene Suite were used for data-mining. Animals were sorted into seven groups (n = 6): (1) Control group: corn oil, (2) P: probiotic: Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus plantarum LP 6595 + Lactobacillus plantarum HEAL9; (3) DEHP: 50 mg/kg b.w./day, (4) DBP: 50 mg/kg b.w./day, (5) BPA: 25 mg/kg b.w./day, and (6) MIX: 50 mg/kg b.w./day DEHP + 50 mg/kg b.w/ day DBP + 25 mg/kg b.w./day BPA; (7) MIX + P. Rats were sacrificed after 28 days of oral exposure. In silico investigation highlighted 44 DEHP, DBP and BPA mutual genes linked to the T2DM, while apoptosis and oxidative stress were highlighted as the main mechanisms of DEHP, DBP and BPA mixture-linked T2DM. In vivo experiment confirmed the presence of significant changes in redox status parameters (TOS, SOD and SH groups) only in the MIX group, indicating possible additive effects, while probiotic ameliorated mixture-induced redox status changes in rat pancreatic tissue.
PB  - Elsevier
T2  - Food and Chemical Toxicology
T1  - Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis
VL  - 154
DO  - 10.1016/j.fct.2021.112325
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Jorgovanović, Dragica and Bojanin, Dragana and Radovanović, Jelena and Gojković, Tamara and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Mandinić, Zoran and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2021",
abstract = "Linkage between bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA) coexposure and type 2 diabetes mellitus (T2DM), as well as ability of multi-strained probiotic to reduce DEHP, DBP and BPA mixture-induced oxidative damage in rat pancreas were investigated. The Comparative Toxicogenomics Database, Cytoscape software and ToppGene Suite were used for data-mining. Animals were sorted into seven groups (n = 6): (1) Control group: corn oil, (2) P: probiotic: Saccharomyces boulardii + Lactobacillus rhamnosus + Lactobacillus plantarum LP 6595 + Lactobacillus plantarum HEAL9; (3) DEHP: 50 mg/kg b.w./day, (4) DBP: 50 mg/kg b.w./day, (5) BPA: 25 mg/kg b.w./day, and (6) MIX: 50 mg/kg b.w./day DEHP + 50 mg/kg b.w/ day DBP + 25 mg/kg b.w./day BPA; (7) MIX + P. Rats were sacrificed after 28 days of oral exposure. In silico investigation highlighted 44 DEHP, DBP and BPA mutual genes linked to the T2DM, while apoptosis and oxidative stress were highlighted as the main mechanisms of DEHP, DBP and BPA mixture-linked T2DM. In vivo experiment confirmed the presence of significant changes in redox status parameters (TOS, SOD and SH groups) only in the MIX group, indicating possible additive effects, while probiotic ameliorated mixture-induced redox status changes in rat pancreatic tissue.",
publisher = "Elsevier",
journal = "Food and Chemical Toxicology",
title = "Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis",
volume = "154",
doi = "10.1016/j.fct.2021.112325"
}

Baralić, K., Živančević, K., Jorgovanović, D., Bojanin, D., Radovanović, J., Gojković, T., Buha-Đorđević, A., Ćurčić, M., Mandinić, Z., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2021). Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis. in Food and Chemical Toxicology
Elsevier., 154.
https://doi.org/10.1016/j.fct.2021.112325

Baralić K, Živančević K, Jorgovanović D, Bojanin D, Radovanović J, Gojković T, Buha-Đorđević A, Ćurčić M, Mandinić Z, Bulat Z, Antonijević B, Đukić-Ćosić D. Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis. in Food and Chemical Toxicology. 2021;154.
doi:10.1016/j.fct.2021.112325 .

Baralić, Katarina, Živančević, Katarina, Jorgovanović, Dragica, Bojanin, Dragana, Radovanović, Jelena, Gojković, Tamara, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Mandinić, Zoran, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Probiotic reduced the impact of phthalates and bisphenol A mixture on type 2 diabetes mellitus development: Merging bioinformatics with in vivo analysis" in Food and Chemical Toxicology, 154 (2021),
https://doi.org/10.1016/j.fct.2021.112325 . .

TY  - JOUR
AU  - Ninić, Ana
AU  - Bojanin, Dragana
AU  - Sopić, Miron
AU  - Mihajlović, Marija
AU  - Munjas, Jelena
AU  - Milenković, Tatjana
AU  - Stefanović, Aleksandra
AU  - Vekić, Jelena
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3799
AB  - Objective: Type 1 diabetes (T1D) mellitus is one of the most frequent autoimmune diseases in childhood. Chronic complications are the main causes of cardiovascular morbidity and mortality in T1D. Although interactions between advanced glycation end products (AGE) and their receptors (RAGE) and transforming growth factor-β1 (TGF-β1) are implicated in development and progression of diabetic micro-and macro-vascular complications, they also have important roles in immune system regulation. Methods: Blood samples were obtained from 156 adolescents with T1D and 80 apparently healthy controls. T1D patients diagnosed with any other autoimmune disease and receiving any kind of drugs except insulin therapy were excluded from this study. Exclusion criteria for controls were positive family history of T1D and drugs/supplements application. TGF-β1 and transmembrane full-length RAGE (flRAGE) messenger ribonucleic acid (mRNA) levels in peripheral blood mononuclear cells (PBMC) were obtained by quantitative polymerase chain reaction (qPCR) method. Circulating levels of biochemical markers, TGF-β1 and soluble RAGE (sRAGE) levels were also determined. Results: TGF-β1 and flRAGE mRNA levels were significantly higher in controls compared to patients (p<0.001, for both). However, TGF-β1 and sRAGE levels were higher in patients than controls (p<0.001, for both). There were significant independent associations of all mRNA and protein levels with T1D. TGF-β1 mRNA was the only marker independently negatively associated with urinary albumin excretion rate in T1D adolescents (p=0.005). Conclusion: Our results indicated gene expression downregulation of TGF-β1 and flRAGE in PBMC of T1D adolescents. TGF-β1 mRNA downregulation may be useful for predicting early elevation of urinary albumin excretion rate.
PB  - Galenos
T2  - JCRPE Journal of Clinical Research in Pediatric Endocrinology
T1  - Transforming growth factor-β1 and receptor for advanced glycation end products gene expression and protein levels in adolescents with type 1 diabetes mellitus
VL  - 13
IS  - 1
SP  - 61
EP  - 71
DO  - 10.4274/jcrpe.galenos.2020.2020.0155
ER  - 

@article{
author = "Ninić, Ana and Bojanin, Dragana and Sopić, Miron and Mihajlović, Marija and Munjas, Jelena and Milenković, Tatjana and Stefanović, Aleksandra and Vekić, Jelena and Spasojević-Kalimanovska, Vesna",
year = "2021",
abstract = "Objective: Type 1 diabetes (T1D) mellitus is one of the most frequent autoimmune diseases in childhood. Chronic complications are the main causes of cardiovascular morbidity and mortality in T1D. Although interactions between advanced glycation end products (AGE) and their receptors (RAGE) and transforming growth factor-β1 (TGF-β1) are implicated in development and progression of diabetic micro-and macro-vascular complications, they also have important roles in immune system regulation. Methods: Blood samples were obtained from 156 adolescents with T1D and 80 apparently healthy controls. T1D patients diagnosed with any other autoimmune disease and receiving any kind of drugs except insulin therapy were excluded from this study. Exclusion criteria for controls were positive family history of T1D and drugs/supplements application. TGF-β1 and transmembrane full-length RAGE (flRAGE) messenger ribonucleic acid (mRNA) levels in peripheral blood mononuclear cells (PBMC) were obtained by quantitative polymerase chain reaction (qPCR) method. Circulating levels of biochemical markers, TGF-β1 and soluble RAGE (sRAGE) levels were also determined. Results: TGF-β1 and flRAGE mRNA levels were significantly higher in controls compared to patients (p<0.001, for both). However, TGF-β1 and sRAGE levels were higher in patients than controls (p<0.001, for both). There were significant independent associations of all mRNA and protein levels with T1D. TGF-β1 mRNA was the only marker independently negatively associated with urinary albumin excretion rate in T1D adolescents (p=0.005). Conclusion: Our results indicated gene expression downregulation of TGF-β1 and flRAGE in PBMC of T1D adolescents. TGF-β1 mRNA downregulation may be useful for predicting early elevation of urinary albumin excretion rate.",
publisher = "Galenos",
journal = "JCRPE Journal of Clinical Research in Pediatric Endocrinology",
title = "Transforming growth factor-β1 and receptor for advanced glycation end products gene expression and protein levels in adolescents with type 1 diabetes mellitus",
volume = "13",
number = "1",
pages = "61-71",
doi = "10.4274/jcrpe.galenos.2020.2020.0155"
}

Ninić, A., Bojanin, D., Sopić, M., Mihajlović, M., Munjas, J., Milenković, T., Stefanović, A., Vekić, J.,& Spasojević-Kalimanovska, V.. (2021). Transforming growth factor-β1 and receptor for advanced glycation end products gene expression and protein levels in adolescents with type 1 diabetes mellitus. in JCRPE Journal of Clinical Research in Pediatric Endocrinology
Galenos., 13(1), 61-71.
https://doi.org/10.4274/jcrpe.galenos.2020.2020.0155

Ninić A, Bojanin D, Sopić M, Mihajlović M, Munjas J, Milenković T, Stefanović A, Vekić J, Spasojević-Kalimanovska V. Transforming growth factor-β1 and receptor for advanced glycation end products gene expression and protein levels in adolescents with type 1 diabetes mellitus. in JCRPE Journal of Clinical Research in Pediatric Endocrinology. 2021;13(1):61-71.
doi:10.4274/jcrpe.galenos.2020.2020.0155 .

Ninić, Ana, Bojanin, Dragana, Sopić, Miron, Mihajlović, Marija, Munjas, Jelena, Milenković, Tatjana, Stefanović, Aleksandra, Vekić, Jelena, Spasojević-Kalimanovska, Vesna, "Transforming growth factor-β1 and receptor for advanced glycation end products gene expression and protein levels in adolescents with type 1 diabetes mellitus" in JCRPE Journal of Clinical Research in Pediatric Endocrinology, 13, no. 1 (2021):61-71,
https://doi.org/10.4274/jcrpe.galenos.2020.2020.0155 . .

TY  - THES
AU  - Bojanin, Dragana
PY  - 2020
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=7586
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:22516/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=18003465
UR  - http://nardus.mpn.gov.rs/handle/123456789/17432
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3702
AB  - Cilj ove disertacije je bio određivanje lipidnih i inflamatornih markera ateroskleroze kod dece sa tipom 1 dijabetes melitusa (T1DM) (N=201) i zdrave dece (N=141), ispitivanje njihove međusobne povezanosti, kao i uticaja metaboličke kontrole i komorbiditeta na analizirane parametre. To je uključilo određivanje standardnog lipidnog profila, veličine i raspodele subfrakcija lipoproteina niske (LDL) i visoke (HDL) gustine, koncentracije proprotein konvertaze subtilisin keksin tip 9 (PCSK9), koncentracije i genske ekspresije receptora za krajnje produkte uznapredovale glikacije (RAGE) i transformišućeg faktora rasta β1 (TGF-β1) u mononuklearnim ćelijama periferne krvi. U grupi sa T1DM bilo je 30 pacijenata sa pridruženim autoimunskim tireoiditisom i 15 sa pridruženom celijačnom bolešću. Koncentracije HDL-holesterola su bile više kod dece sa T1DM u odnosu na zdravu decu, dok se drugi parametri lipidnog profila nisu značajno razlikovali. Pacijenti sa neadekvatnom metaboličkom kontrolom su imali više koncentracije PCSK9 i veće udele malih HDL subfrakcija. U grupi sa dobrom metaboličkom kontrolom je utvrđena negativna korelacija između koncentracija PCSK9 i udela malih LDL čestica. Ekspresija gena za RAGE i TGF-β1 je bila značajno niža, a koncentracije značajno više kod dece sa T1DM. Koncentracije TGF-β1 u plazmi pacijenata sa T1DM su pozitivno korelirale sa udelom malih HDL subfrakcija, a genska ekspresija sa povećanom ekskrecijom albumina. Pacijenti sa pridruženom celijačnom bolešću su imali najniže koncentracije HDL-holesterola, najmanje dijametre HDL čestica i najveći indeks ateroskleroze. Rezultati su ukazali na značaj određivanja lipidnih i inflamatornih markera i ranog povećanja ekskrecije albumina u prevenciji dijabetesnih komplikacija.
AB  - The aim of this thesis was to determine lipid and inflammatory markers of atherosclerosis in children with type 1 diabetes mellitus (T1DM) (N=201) and healthy children (N=141), to investigate their mutual relationships and the effects of metabolic control and comorbidities on examined markers. Standard lipid profile, low-density (LDL) and high-density (HDL) size and subclasses distribution, concentration of proprotein convertase subtilisin kexin type 9 (PCSK9), and concentrations and gene expression of receptor for advanced glycation end-products (RAGE) and transforming growth factor β1 (TGF-β1) in peripheral blood mononuclear cells were determined. In T1DM group 30 patients had associated autoimmune thyroiditis and 15 patients had celiac disease. HDL-cholesterol (HDL-C) levels were higher in children with T1DM, while other lipid status parameters did not differ between the groups. Patients with inadequate metabolic control had increased PCSK9 levels and higher proportion of small HDL subfractions. In the group with good metabolic control an inverse association between PCSK9 level and proportion of small LDL particles was found. Gene expression of RAGE and TGF-β1 was significantly lower and plasma concentrations were significantly higher in children with T1DM. TGF-β1 levels in plasma of T1DM patients were positively associated with the proportion of small HDL subfractions, and higher gene expression was associated with increased albumin excretion. Patients with associated celiac disease had the lowest concentrations of HDL-C, the smallest diameter of HDL particles, and the highest index of atherosclerosis. The results indicated importance of lipid and inflammatory markers and early increase of albumin excretion determination for prevention of diabetic complications.
PB  - Универзитет у Београду, Фармацеутски факултет
T2  - Универзитет у Београду
T1  - Rani lipidni i inflamatorni markeri ateroskleroze kod dece sa tipom 1 dijabetes melitusa: uticaj metaboličke kontrole i komorbiditeta
UR  - https://hdl.handle.net/21.15107/rcub_nardus_17432
ER  - 

@phdthesis{
author = "Bojanin, Dragana",
year = "2020",
abstract = "Cilj ove disertacije je bio određivanje lipidnih i inflamatornih markera ateroskleroze kod dece sa tipom 1 dijabetes melitusa (T1DM) (N=201) i zdrave dece (N=141), ispitivanje njihove međusobne povezanosti, kao i uticaja metaboličke kontrole i komorbiditeta na analizirane parametre. To je uključilo određivanje standardnog lipidnog profila, veličine i raspodele subfrakcija lipoproteina niske (LDL) i visoke (HDL) gustine, koncentracije proprotein konvertaze subtilisin keksin tip 9 (PCSK9), koncentracije i genske ekspresije receptora za krajnje produkte uznapredovale glikacije (RAGE) i transformišućeg faktora rasta β1 (TGF-β1) u mononuklearnim ćelijama periferne krvi. U grupi sa T1DM bilo je 30 pacijenata sa pridruženim autoimunskim tireoiditisom i 15 sa pridruženom celijačnom bolešću. Koncentracije HDL-holesterola su bile više kod dece sa T1DM u odnosu na zdravu decu, dok se drugi parametri lipidnog profila nisu značajno razlikovali. Pacijenti sa neadekvatnom metaboličkom kontrolom su imali više koncentracije PCSK9 i veće udele malih HDL subfrakcija. U grupi sa dobrom metaboličkom kontrolom je utvrđena negativna korelacija između koncentracija PCSK9 i udela malih LDL čestica. Ekspresija gena za RAGE i TGF-β1 je bila značajno niža, a koncentracije značajno više kod dece sa T1DM. Koncentracije TGF-β1 u plazmi pacijenata sa T1DM su pozitivno korelirale sa udelom malih HDL subfrakcija, a genska ekspresija sa povećanom ekskrecijom albumina. Pacijenti sa pridruženom celijačnom bolešću su imali najniže koncentracije HDL-holesterola, najmanje dijametre HDL čestica i najveći indeks ateroskleroze. Rezultati su ukazali na značaj određivanja lipidnih i inflamatornih markera i ranog povećanja ekskrecije albumina u prevenciji dijabetesnih komplikacija., The aim of this thesis was to determine lipid and inflammatory markers of atherosclerosis in children with type 1 diabetes mellitus (T1DM) (N=201) and healthy children (N=141), to investigate their mutual relationships and the effects of metabolic control and comorbidities on examined markers. Standard lipid profile, low-density (LDL) and high-density (HDL) size and subclasses distribution, concentration of proprotein convertase subtilisin kexin type 9 (PCSK9), and concentrations and gene expression of receptor for advanced glycation end-products (RAGE) and transforming growth factor β1 (TGF-β1) in peripheral blood mononuclear cells were determined. In T1DM group 30 patients had associated autoimmune thyroiditis and 15 patients had celiac disease. HDL-cholesterol (HDL-C) levels were higher in children with T1DM, while other lipid status parameters did not differ between the groups. Patients with inadequate metabolic control had increased PCSK9 levels and higher proportion of small HDL subfractions. In the group with good metabolic control an inverse association between PCSK9 level and proportion of small LDL particles was found. Gene expression of RAGE and TGF-β1 was significantly lower and plasma concentrations were significantly higher in children with T1DM. TGF-β1 levels in plasma of T1DM patients were positively associated with the proportion of small HDL subfractions, and higher gene expression was associated with increased albumin excretion. Patients with associated celiac disease had the lowest concentrations of HDL-C, the smallest diameter of HDL particles, and the highest index of atherosclerosis. The results indicated importance of lipid and inflammatory markers and early increase of albumin excretion determination for prevention of diabetic complications.",
publisher = "Универзитет у Београду, Фармацеутски факултет",
journal = "Универзитет у Београду",
title = "Rani lipidni i inflamatorni markeri ateroskleroze kod dece sa tipom 1 dijabetes melitusa: uticaj metaboličke kontrole i komorbiditeta",
url = "https://hdl.handle.net/21.15107/rcub_nardus_17432"
}

Bojanin, D.. (2020). Rani lipidni i inflamatorni markeri ateroskleroze kod dece sa tipom 1 dijabetes melitusa: uticaj metaboličke kontrole i komorbiditeta. in Универзитет у Београду
Универзитет у Београду, Фармацеутски факултет..
https://hdl.handle.net/21.15107/rcub_nardus_17432

Bojanin D. Rani lipidni i inflamatorni markeri ateroskleroze kod dece sa tipom 1 dijabetes melitusa: uticaj metaboličke kontrole i komorbiditeta. in Универзитет у Београду. 2020;.
https://hdl.handle.net/21.15107/rcub_nardus_17432 .

Bojanin, Dragana, "Rani lipidni i inflamatorni markeri ateroskleroze kod dece sa tipom 1 dijabetes melitusa: uticaj metaboličke kontrole i komorbiditeta" in Универзитет у Београду (2020),
https://hdl.handle.net/21.15107/rcub_nardus_17432 .

TY  - JOUR
AU  - Bojanin, Dragana
AU  - Vekić, Jelena
AU  - Milenković, Tatjana
AU  - Vuković, Rade
AU  - Zeljković, Aleksandra
AU  - Stefanović, Aleksandra
AU  - Janać, Jelena
AU  - Ivanišević, Jasmina
AU  - Mitrović, Katarina
AU  - Miljković, Milica
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3326
AB  - Background and aims: Dyslipidemia in type 1 diabetes mellitus (T1DM) is characterised by altered distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses. Recent studies suggested that proprotein convertase subtilisin/kexin 9 (PCSK9) may contribute to the development of dyslipidemia in T1DM. In this cross-sectional study, we investigated the association between PCSK9 and lipoprotein subclasses in young T1DM patients, with respect to glycemic control. Methods: Plasma PCSK9 and lipoprotein subclasses were determined in 207 patients with T1DM (106 boys and 101 girls), aged 13.9 +/- 3.0 years and treated by intensive insulin therapy. Results: Plasma PCSK9 levels significantly increased with worsening of glycemic control (p  lt  0.001). T1DM patients with poor glucoregulation had the highest proportion of small, dense LDL (sdLDL) and smaller HDL particles, as well. PCSK9 was positively associated with markers of glucose homeostasis and serum lipid parameters only in patients with suboptimal/poor glucoregulation. In well-controlled T1DM, plasma PCSK9 level was inversely associated with a relative proportion of sdLDL particles (p  lt  0.01) and this association remained significant in multivariate analysis. In T1DM patients with suboptimal/poor glycemic control, PCSK9 was positively associated with the proportion of the smallest HDL3c particles (p  lt  0.001), but negatively with HDL size (p  lt  0.05). Conclusions: The extent of achieved metabolic control modifies the association between PCSK9 and lipoprotein subclasses in T1DM. Further investigations are needed to reveal whether the observed effects of glycemic control on PCSK9 and sdLDL levels have causal consequences on CVD risk in young patients with T1DM.
PB  - Elsevier Ireland Ltd, Clare
T2  - Atherosclerosis
T1  - Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control
VL  - 280
SP  - 14
EP  - 20
DO  - 10.1016/j.atherosclerosis.2018.11.020
ER  - 

@article{
author = "Bojanin, Dragana and Vekić, Jelena and Milenković, Tatjana and Vuković, Rade and Zeljković, Aleksandra and Stefanović, Aleksandra and Janać, Jelena and Ivanišević, Jasmina and Mitrović, Katarina and Miljković, Milica and Spasojević-Kalimanovska, Vesna",
year = "2019",
abstract = "Background and aims: Dyslipidemia in type 1 diabetes mellitus (T1DM) is characterised by altered distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses. Recent studies suggested that proprotein convertase subtilisin/kexin 9 (PCSK9) may contribute to the development of dyslipidemia in T1DM. In this cross-sectional study, we investigated the association between PCSK9 and lipoprotein subclasses in young T1DM patients, with respect to glycemic control. Methods: Plasma PCSK9 and lipoprotein subclasses were determined in 207 patients with T1DM (106 boys and 101 girls), aged 13.9 +/- 3.0 years and treated by intensive insulin therapy. Results: Plasma PCSK9 levels significantly increased with worsening of glycemic control (p  lt  0.001). T1DM patients with poor glucoregulation had the highest proportion of small, dense LDL (sdLDL) and smaller HDL particles, as well. PCSK9 was positively associated with markers of glucose homeostasis and serum lipid parameters only in patients with suboptimal/poor glucoregulation. In well-controlled T1DM, plasma PCSK9 level was inversely associated with a relative proportion of sdLDL particles (p  lt  0.01) and this association remained significant in multivariate analysis. In T1DM patients with suboptimal/poor glycemic control, PCSK9 was positively associated with the proportion of the smallest HDL3c particles (p  lt  0.001), but negatively with HDL size (p  lt  0.05). Conclusions: The extent of achieved metabolic control modifies the association between PCSK9 and lipoprotein subclasses in T1DM. Further investigations are needed to reveal whether the observed effects of glycemic control on PCSK9 and sdLDL levels have causal consequences on CVD risk in young patients with T1DM.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Atherosclerosis",
title = "Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control",
volume = "280",
pages = "14-20",
doi = "10.1016/j.atherosclerosis.2018.11.020"
}

Bojanin, D., Vekić, J., Milenković, T., Vuković, R., Zeljković, A., Stefanović, A., Janać, J., Ivanišević, J., Mitrović, K., Miljković, M.,& Spasojević-Kalimanovska, V.. (2019). Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control. in Atherosclerosis
Elsevier Ireland Ltd, Clare., 280, 14-20.
https://doi.org/10.1016/j.atherosclerosis.2018.11.020

Bojanin D, Vekić J, Milenković T, Vuković R, Zeljković A, Stefanović A, Janać J, Ivanišević J, Mitrović K, Miljković M, Spasojević-Kalimanovska V. Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control. in Atherosclerosis. 2019;280:14-20.
doi:10.1016/j.atherosclerosis.2018.11.020 .

Bojanin, Dragana, Vekić, Jelena, Milenković, Tatjana, Vuković, Rade, Zeljković, Aleksandra, Stefanović, Aleksandra, Janać, Jelena, Ivanišević, Jasmina, Mitrović, Katarina, Miljković, Milica, Spasojević-Kalimanovska, Vesna, "Association between proprotein convertase subtilisin/kexin 9 (PCSK9) and lipoprotein subclasses in children with type 1 diabetes mellitus: Effects of glycemic control" in Atherosclerosis, 280 (2019):14-20,
https://doi.org/10.1016/j.atherosclerosis.2018.11.020 . .

TY  - JOUR
AU  - Bojanin, Dragana
AU  - Milenković, Tatjana
AU  - Vekić, Jelena
AU  - Vuković, Rade
AU  - Zeljković, Aleksandra
AU  - Janać, Jelena
AU  - Ivanišević, Jasmina
AU  - Todorović, Slađana
AU  - Mazibrada, Ilijana
AU  - Spasojević-Kalimanovska, Vesna
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3153
AB  - Objective: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. Design and methods: Study included 201 subjects with T1DM (14.1 +/- 2.9 years) and 141 age-and gender-matched controls. ATD was presented in 30 and CD in 15 T1DM patients. Serum lipid parameters were determined by routine laboratory methods and plasma low-density (LDL) and high-density lipoprotein (HDL) subclasses by gradient-gel electrophoresis method. Results: Both groups of T1DM patients with concomitant autoimmune disease had significantly lower HDL-C levels (P  lt  0.05) than the patients with T1DM only, but comparable to control group (P = 0.436). T1DM patients had significantly higher (P  lt  0.001) proportion of small HDL subclasses than controls. Mean value of atherosclerosis index in patients with T1DM + CD was the highest (1.75 +/- 0.86) and it was significantly higher than the index in patients with T1DM only (1.33 +/- 0.51; P  lt  0.05). LDL size did not differ between the groups of T1DM patients and control group (P= 0.619). The size of HDL particles was significantly reduced (P  lt  0.05) in the groups with associated autoimmune diseases. The patients with co-existing autoimmune diseases had higher risk of low HDL-C level (OR: 2.96; P  lt  0.05). Conclusions: The results have shown significant impact of co-existing autoimmune diseases on lipid profile in patients with T1DM. The most prominent changes were found in HDL lipoprotein characteristics in T1DM + CD group.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus
VL  - 54
SP  - 11
EP  - 17
DO  - 10.1016/j.clinbiochem.2018.01.026
ER  - 

@article{
author = "Bojanin, Dragana and Milenković, Tatjana and Vekić, Jelena and Vuković, Rade and Zeljković, Aleksandra and Janać, Jelena and Ivanišević, Jasmina and Todorović, Slađana and Mazibrada, Ilijana and Spasojević-Kalimanovska, Vesna",
year = "2018",
abstract = "Objective: Paediatric patients with type 1 diabetes mellitus (T1DM) frequently develop other autoimmune disorders; most commonly autoimmune thyroiditis (ATD) and celiac disease (CD). In this study we evaluated whether co-existing autoimmune diseases had significant impact on lipid and lipoprotein subclasses, as known cardiovascular risk factors in T1DM. Design and methods: Study included 201 subjects with T1DM (14.1 +/- 2.9 years) and 141 age-and gender-matched controls. ATD was presented in 30 and CD in 15 T1DM patients. Serum lipid parameters were determined by routine laboratory methods and plasma low-density (LDL) and high-density lipoprotein (HDL) subclasses by gradient-gel electrophoresis method. Results: Both groups of T1DM patients with concomitant autoimmune disease had significantly lower HDL-C levels (P  lt  0.05) than the patients with T1DM only, but comparable to control group (P = 0.436). T1DM patients had significantly higher (P  lt  0.001) proportion of small HDL subclasses than controls. Mean value of atherosclerosis index in patients with T1DM + CD was the highest (1.75 +/- 0.86) and it was significantly higher than the index in patients with T1DM only (1.33 +/- 0.51; P  lt  0.05). LDL size did not differ between the groups of T1DM patients and control group (P= 0.619). The size of HDL particles was significantly reduced (P  lt  0.05) in the groups with associated autoimmune diseases. The patients with co-existing autoimmune diseases had higher risk of low HDL-C level (OR: 2.96; P  lt  0.05). Conclusions: The results have shown significant impact of co-existing autoimmune diseases on lipid profile in patients with T1DM. The most prominent changes were found in HDL lipoprotein characteristics in T1DM + CD group.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus",
volume = "54",
pages = "11-17",
doi = "10.1016/j.clinbiochem.2018.01.026"
}

Bojanin, D., Milenković, T., Vekić, J., Vuković, R., Zeljković, A., Janać, J., Ivanišević, J., Todorović, S., Mazibrada, I.,& Spasojević-Kalimanovska, V.. (2018). Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 54, 11-17.
https://doi.org/10.1016/j.clinbiochem.2018.01.026

Bojanin D, Milenković T, Vekić J, Vuković R, Zeljković A, Janać J, Ivanišević J, Todorović S, Mazibrada I, Spasojević-Kalimanovska V. Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus. in Clinical Biochemistry. 2018;54:11-17.
doi:10.1016/j.clinbiochem.2018.01.026 .

Bojanin, Dragana, Milenković, Tatjana, Vekić, Jelena, Vuković, Rade, Zeljković, Aleksandra, Janać, Jelena, Ivanišević, Jasmina, Todorović, Slađana, Mazibrada, Ilijana, Spasojević-Kalimanovska, Vesna, "Effects of co-existing autoimmune diseases on serum lipids and lipoprotein subclasses profile in paediatric patients with type 1 diabetes mellitus" in Clinical Biochemistry, 54 (2018):11-17,
https://doi.org/10.1016/j.clinbiochem.2018.01.026 . .

TY  - JOUR
AU  - Kuburović, Vladimir
AU  - Vekić, Jelena
AU  - Zeljković, Aleksandra
AU  - Carrie, Alain
AU  - Kotur-Stevuljević, Jelena
AU  - Bojanin, Dragana
AU  - Kosutić, Jovan
AU  - Spasojević-Kalimanovska, Vesna
AU  - Miljković, Milica
AU  - Kuburović, Nina
AU  - Couvert, Philippe
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2840
AB  - Objective: Plasma high-density lipoprotein cholesterol (HDL-C) level is a strong inverse predictor of cardiovascular disease (CVD) development. Tangier disease, a consequence of mutations in the ATP binding cassette transporter 1 (ABCA1) gene, is associated with very low HDL-C levels. Still, the relationship between Tangier disease and CVD is not always evident. The study investigates usefulness of lipoprotein subfractions, oxidative stress and paraoxonase 1 (PON1) status assessment for evaluation and management of patient with low HDL-C phenotype. Patient and methods: A 12-year-old boy was hospitalised due to hypertension. Laboratory evaluation revealed low HDL-C level, and subsequent molecular diagnostic confirmed Tangier disease. Lipoprotein subfractions were assessed by gradient-gel electrophoresis. Oxidative stress status was estimated by measuring total antioxidative status, total oxidative status, prooxidative-antioxidative balance, malondialdehyde and advanced oxidation protein products levels. Activity of paraoxonase 1 in serum and its distribution within HDL subclasses was also determined (ten healthy boys aged 13.1 +/- 3.4 years served as the reference group). Results: Analysis of oxidative stress status biomarkers revealed a state of prolonged prooxidants activity. In turn, serum PON1 activity was substantially reduced. The majority of PON1 activity was present on HDL 2 particles. Conclusion: Impaired antioxidative potential of HDL may point toward hidden cardiovascular risk in isolated low HDL-phenotype.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report
VL  - 50
IS  - 18
SP  - 1323
EP  - 1325
DO  - 10.1016/j.clinbiochem.2017.06.007
ER  - 

@article{
author = "Kuburović, Vladimir and Vekić, Jelena and Zeljković, Aleksandra and Carrie, Alain and Kotur-Stevuljević, Jelena and Bojanin, Dragana and Kosutić, Jovan and Spasojević-Kalimanovska, Vesna and Miljković, Milica and Kuburović, Nina and Couvert, Philippe",
year = "2017",
abstract = "Objective: Plasma high-density lipoprotein cholesterol (HDL-C) level is a strong inverse predictor of cardiovascular disease (CVD) development. Tangier disease, a consequence of mutations in the ATP binding cassette transporter 1 (ABCA1) gene, is associated with very low HDL-C levels. Still, the relationship between Tangier disease and CVD is not always evident. The study investigates usefulness of lipoprotein subfractions, oxidative stress and paraoxonase 1 (PON1) status assessment for evaluation and management of patient with low HDL-C phenotype. Patient and methods: A 12-year-old boy was hospitalised due to hypertension. Laboratory evaluation revealed low HDL-C level, and subsequent molecular diagnostic confirmed Tangier disease. Lipoprotein subfractions were assessed by gradient-gel electrophoresis. Oxidative stress status was estimated by measuring total antioxidative status, total oxidative status, prooxidative-antioxidative balance, malondialdehyde and advanced oxidation protein products levels. Activity of paraoxonase 1 in serum and its distribution within HDL subclasses was also determined (ten healthy boys aged 13.1 +/- 3.4 years served as the reference group). Results: Analysis of oxidative stress status biomarkers revealed a state of prolonged prooxidants activity. In turn, serum PON1 activity was substantially reduced. The majority of PON1 activity was present on HDL 2 particles. Conclusion: Impaired antioxidative potential of HDL may point toward hidden cardiovascular risk in isolated low HDL-phenotype.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report",
volume = "50",
number = "18",
pages = "1323-1325",
doi = "10.1016/j.clinbiochem.2017.06.007"
}

Kuburović, V., Vekić, J., Zeljković, A., Carrie, A., Kotur-Stevuljević, J., Bojanin, D., Kosutić, J., Spasojević-Kalimanovska, V., Miljković, M., Kuburović, N.,& Couvert, P.. (2017). The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 50(18), 1323-1325.
https://doi.org/10.1016/j.clinbiochem.2017.06.007

Kuburović V, Vekić J, Zeljković A, Carrie A, Kotur-Stevuljević J, Bojanin D, Kosutić J, Spasojević-Kalimanovska V, Miljković M, Kuburović N, Couvert P. The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report. in Clinical Biochemistry. 2017;50(18):1323-1325.
doi:10.1016/j.clinbiochem.2017.06.007 .

Kuburović, Vladimir, Vekić, Jelena, Zeljković, Aleksandra, Carrie, Alain, Kotur-Stevuljević, Jelena, Bojanin, Dragana, Kosutić, Jovan, Spasojević-Kalimanovska, Vesna, Miljković, Milica, Kuburović, Nina, Couvert, Philippe, "The usefulness of advanced lipid and oxidative stress testing for diagnosis and management of low HDL-cholesterol phenotype: A case report" in Clinical Biochemistry, 50, no. 18 (2017):1323-1325,
https://doi.org/10.1016/j.clinbiochem.2017.06.007 . .