TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Šćepanović, A.
AU  - Kotur-Stevuljević, Jelena
AU  - Ninić, Ana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4174
AB  - OBJECTIVE: To our knowledge, there are no studies that investigated the relationship between diabetes mellitus type 2 (T2D) and some novel indexes, such as monocyte/granulocyte to lymphocyte ratio (M/GLR), derived neutrophil to lymphocyte ratio (dNLR), and platelets to neutrophil ratio (PNR). The aim of this study was to examine the association between these novel indexes and glycated hemoglobin (HbA1c) in patients with prediabetes and T2D. PATIENTS AND METHODS: A total of 827 participants were consecutively recruited. According to the American Diabetes Association (ADA) criteria, participants were divided into control, prediabetes, and T2D group. RESULTS: White blood cell count (WBC), neutrophil count, NLR, dNLR, and M/GLR were higher in T2D patients than in the other two groups, whereas PNR was the lowest in T2D group. Lymphocyte count was higher in prediabetes and T2D patients than in control group. Multivariable ordinal regression analysis showed that WBC, neutrophil count, lymphocyte count, NLR, dNLR, and M/GLR were positively associated [OR (95% CI) 1.287 (1.191-1.390), p<0.001; 1.427 (1.275-1.594), p<0.001; 1.347 (1.130- 1.606), p=0.001; 1.350 (1.090-1.670), p=0.006; 1.662 (1.189-2.326), p=0.003; 1.275 (1.057-1.540), p=0.012, respectively] with HbA1c. However, PNR was negatively associated with HbA1c [0.987 (0.981-0.993), p<0.001]. CONCLUSIONS: Novel, modified NLR indexes, such as dNLR and M/GLR were independently correlated with HbA1c. Also, PNR showed superiority over platelets (PLT) in relation to HbA1c. These novel indexes might give a significant contribution to the timely recognition of disturbances of glucose homeostasis in patients with prediabetes and overt diabetes.
PB  - Verduci Editore srl
T2  - European Review for Medical and Pharmacological Sciences
T1  - Novel leukocyte and thrombocyte indexes in patients with prediabetes and type 2 diabetes mellitus
VL  - 26
IS  - 8
SP  - 2775
EP  - 2781
DO  - 10.26355/eurrev_202204_28607
ER  - 

@article{
author = "Klisić, Aleksandra and Šćepanović, A. and Kotur-Stevuljević, Jelena and Ninić, Ana",
year = "2022",
abstract = "OBJECTIVE: To our knowledge, there are no studies that investigated the relationship between diabetes mellitus type 2 (T2D) and some novel indexes, such as monocyte/granulocyte to lymphocyte ratio (M/GLR), derived neutrophil to lymphocyte ratio (dNLR), and platelets to neutrophil ratio (PNR). The aim of this study was to examine the association between these novel indexes and glycated hemoglobin (HbA1c) in patients with prediabetes and T2D. PATIENTS AND METHODS: A total of 827 participants were consecutively recruited. According to the American Diabetes Association (ADA) criteria, participants were divided into control, prediabetes, and T2D group. RESULTS: White blood cell count (WBC), neutrophil count, NLR, dNLR, and M/GLR were higher in T2D patients than in the other two groups, whereas PNR was the lowest in T2D group. Lymphocyte count was higher in prediabetes and T2D patients than in control group. Multivariable ordinal regression analysis showed that WBC, neutrophil count, lymphocyte count, NLR, dNLR, and M/GLR were positively associated [OR (95% CI) 1.287 (1.191-1.390), p<0.001; 1.427 (1.275-1.594), p<0.001; 1.347 (1.130- 1.606), p=0.001; 1.350 (1.090-1.670), p=0.006; 1.662 (1.189-2.326), p=0.003; 1.275 (1.057-1.540), p=0.012, respectively] with HbA1c. However, PNR was negatively associated with HbA1c [0.987 (0.981-0.993), p<0.001]. CONCLUSIONS: Novel, modified NLR indexes, such as dNLR and M/GLR were independently correlated with HbA1c. Also, PNR showed superiority over platelets (PLT) in relation to HbA1c. These novel indexes might give a significant contribution to the timely recognition of disturbances of glucose homeostasis in patients with prediabetes and overt diabetes.",
publisher = "Verduci Editore srl",
journal = "European Review for Medical and Pharmacological Sciences",
title = "Novel leukocyte and thrombocyte indexes in patients with prediabetes and type 2 diabetes mellitus",
volume = "26",
number = "8",
pages = "2775-2781",
doi = "10.26355/eurrev_202204_28607"
}

Klisić, A., Šćepanović, A., Kotur-Stevuljević, J.,& Ninić, A.. (2022). Novel leukocyte and thrombocyte indexes in patients with prediabetes and type 2 diabetes mellitus. in European Review for Medical and Pharmacological Sciences
Verduci Editore srl., 26(8), 2775-2781.
https://doi.org/10.26355/eurrev_202204_28607

Klisić A, Šćepanović A, Kotur-Stevuljević J, Ninić A. Novel leukocyte and thrombocyte indexes in patients with prediabetes and type 2 diabetes mellitus. in European Review for Medical and Pharmacological Sciences. 2022;26(8):2775-2781.
doi:10.26355/eurrev_202204_28607 .

Klisić, Aleksandra, Šćepanović, A., Kotur-Stevuljević, Jelena, Ninić, Ana, "Novel leukocyte and thrombocyte indexes in patients with prediabetes and type 2 diabetes mellitus" in European Review for Medical and Pharmacological Sciences, 26, no. 8 (2022):2775-2781,
https://doi.org/10.26355/eurrev_202204_28607 . .