TY  - JOUR
AU  - Martić, Radava
AU  - Kotur-Stevuljević, Jelena
AU  - Malenović, Anđelija
AU  - Ušjak, Ljuboš
AU  - Petrović, Silvana
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Krajišnik, Danina
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4200
AB  - Fast inverted, oil-in-water (o/w) emulsions, also known as SWitch-Oil-Phase (SWOP) emulsions, express the performances of both o/w and water-in-oil (w/o) emulsions during application to the skin, favoring their use as cosmetic carriers in sunscreen products. The objective of this study was to investigate the antioxidant potential (by 2 different methods) and the ultraviolet (UV) absorption ability of SWOP emulsion (S) with incorporated plant-based antioxidants dihydroquercetin (DHQ) and β-carotene (βC), using quercetin (Q) in a reference emulsion, in addition to the evaluation of their physicochemical properties and stability. A new biochemical extra- cellular model for in vitro assessment of antioxidative properties for the SWOP emulsions (S, SQ, SDHQ, and SDHQβC) was developed and compared with the results of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay. The analyses were performed at 20 °C and 37 °C, and oxidative stress parameters were monitored and statistically analyzed. The sun protection factor (SPF) of the samples was determined in vitro. Q and DHQ incorporated into the SWOP emulsion exhibited a strong DPPH radical scavenging ability. Neither incorporated nor pure βC showed DPPH radical scavenging ability at the tested concentrations. Contrary to that, in the bioenvironment conditions, SDHQβC showed minor antioxidative effects increase and also a significant decrease in exogenous pro-oxidative effects, caused by pro-oxidant, when compared to SDHQ. The obtained SPFs of SDHQβC, SDHQ, and SQ were 5.19, 4.65, and 3.35, respectively. The phys- icochemical stability of the emulsions was satisfactory during 1 month storage. The presented results demonstrated that the SWOP emul- sion is a suitable carrier for antioxidants with a photoprotective ability. The novel biochemical approach could be used in addition to DPPH assay with several advantages, relevant for the testing of antioxidant activity of potential active ingredients in cosmetic products.
PB  - SAGE Publications Inc.
T2  - Natural Product Communications
T1  - Fast Inverted Photoprotective o/w Emulsions Loaded With Dihydroquercetin and β-Carotene: An Innovative Approach to In Vitro Assessment of Antioxidant Activity in a Bioenvironment
VL  - 17
IS  - 7
DO  - 10.1177/1934578X221112811
ER  - 

@article{
author = "Martić, Radava and Kotur-Stevuljević, Jelena and Malenović, Anđelija and Ušjak, Ljuboš and Petrović, Silvana and Čalija, Bojan and Milić, Jela and Krajišnik, Danina",
year = "2022",
abstract = "Fast inverted, oil-in-water (o/w) emulsions, also known as SWitch-Oil-Phase (SWOP) emulsions, express the performances of both o/w and water-in-oil (w/o) emulsions during application to the skin, favoring their use as cosmetic carriers in sunscreen products. The objective of this study was to investigate the antioxidant potential (by 2 different methods) and the ultraviolet (UV) absorption ability of SWOP emulsion (S) with incorporated plant-based antioxidants dihydroquercetin (DHQ) and β-carotene (βC), using quercetin (Q) in a reference emulsion, in addition to the evaluation of their physicochemical properties and stability. A new biochemical extra- cellular model for in vitro assessment of antioxidative properties for the SWOP emulsions (S, SQ, SDHQ, and SDHQβC) was developed and compared with the results of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay. The analyses were performed at 20 °C and 37 °C, and oxidative stress parameters were monitored and statistically analyzed. The sun protection factor (SPF) of the samples was determined in vitro. Q and DHQ incorporated into the SWOP emulsion exhibited a strong DPPH radical scavenging ability. Neither incorporated nor pure βC showed DPPH radical scavenging ability at the tested concentrations. Contrary to that, in the bioenvironment conditions, SDHQβC showed minor antioxidative effects increase and also a significant decrease in exogenous pro-oxidative effects, caused by pro-oxidant, when compared to SDHQ. The obtained SPFs of SDHQβC, SDHQ, and SQ were 5.19, 4.65, and 3.35, respectively. The phys- icochemical stability of the emulsions was satisfactory during 1 month storage. The presented results demonstrated that the SWOP emul- sion is a suitable carrier for antioxidants with a photoprotective ability. The novel biochemical approach could be used in addition to DPPH assay with several advantages, relevant for the testing of antioxidant activity of potential active ingredients in cosmetic products.",
publisher = "SAGE Publications Inc.",
journal = "Natural Product Communications",
title = "Fast Inverted Photoprotective o/w Emulsions Loaded With Dihydroquercetin and β-Carotene: An Innovative Approach to In Vitro Assessment of Antioxidant Activity in a Bioenvironment",
volume = "17",
number = "7",
doi = "10.1177/1934578X221112811"
}

Martić, R., Kotur-Stevuljević, J., Malenović, A., Ušjak, L., Petrović, S., Čalija, B., Milić, J.,& Krajišnik, D.. (2022). Fast Inverted Photoprotective o/w Emulsions Loaded With Dihydroquercetin and β-Carotene: An Innovative Approach to In Vitro Assessment of Antioxidant Activity in a Bioenvironment. in Natural Product Communications
SAGE Publications Inc.., 17(7).
https://doi.org/10.1177/1934578X221112811

Martić R, Kotur-Stevuljević J, Malenović A, Ušjak L, Petrović S, Čalija B, Milić J, Krajišnik D. Fast Inverted Photoprotective o/w Emulsions Loaded With Dihydroquercetin and β-Carotene: An Innovative Approach to In Vitro Assessment of Antioxidant Activity in a Bioenvironment. in Natural Product Communications. 2022;17(7).
doi:10.1177/1934578X221112811 .

Martić, Radava, Kotur-Stevuljević, Jelena, Malenović, Anđelija, Ušjak, Ljuboš, Petrović, Silvana, Čalija, Bojan, Milić, Jela, Krajišnik, Danina, "Fast Inverted Photoprotective o/w Emulsions Loaded With Dihydroquercetin and β-Carotene: An Innovative Approach to In Vitro Assessment of Antioxidant Activity in a Bioenvironment" in Natural Product Communications, 17, no. 7 (2022),
https://doi.org/10.1177/1934578X221112811 . .

TY  - JOUR
AU  - Račić, Andjelka
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Jurišić Dukovski, Bisera
AU  - Lovrić, Jasmina
AU  - Dobričić, Vladimir
AU  - Micov, Ana
AU  - Vuković, Milja
AU  - Stepanović-Petrović, Radica
AU  - Krajišnik, Danina
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3938
AB  - The aim of this work was the formulation and the comprehensive evaluation of the viscous eye drops using vehicles containing medium chain chitosan (0.5% w/v), hydroxypropyl guar gum (0.25% w/v) and their com-bination as carriers for olopatadine (0.1% w/v). Physicochemical properties (appearance, clarity, pH, osmolality, viscosity and drug content) of the tested formulations were within acceptable ranges for the ophthalmic prep-arations, while DSC and FT-IR techniques demonstrated the compatibility between olopatadine and polymers. The drug permeability was successfully estimated in vitro using both HCE-T cell-based models (Model I and Model II) and the parallel artificial membrane permeability assay (PAMPA), considering the impact of chitosan as a permeation enhancer. The MTT cytotoxicity assay demonstrates that the tested formulations (diluted 10-fold in HBSS pH 5.5) were non-toxic and well tolerated. An ocular itch test on mice was carried out with the formulation containing the combination of polymers comparable with a commercially available olopatadine eye drops without viscosity enhancers. The tested eye drops produced a slightly higher anti-pruritic/analgesic-like effect than the commercial preparation. It could be assumed that the use of this viscous ophthalmic vehicle due to its advanced mucoadhesive properties and good safety profile is a feasible strategy to improve the efficacy of olopatadine.
PB  - Elsevier B.V.
T2  - European Journal of Pharmaceutical Sciences
T1  - Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches
VL  - 166
DO  - 10.1016/j.ejps.2021.105906
ER  - 

@article{
author = "Račić, Andjelka and Čalija, Bojan and Milić, Jela and Jurišić Dukovski, Bisera and Lovrić, Jasmina and Dobričić, Vladimir and Micov, Ana and Vuković, Milja and Stepanović-Petrović, Radica and Krajišnik, Danina",
year = "2021",
abstract = "The aim of this work was the formulation and the comprehensive evaluation of the viscous eye drops using vehicles containing medium chain chitosan (0.5% w/v), hydroxypropyl guar gum (0.25% w/v) and their com-bination as carriers for olopatadine (0.1% w/v). Physicochemical properties (appearance, clarity, pH, osmolality, viscosity and drug content) of the tested formulations were within acceptable ranges for the ophthalmic prep-arations, while DSC and FT-IR techniques demonstrated the compatibility between olopatadine and polymers. The drug permeability was successfully estimated in vitro using both HCE-T cell-based models (Model I and Model II) and the parallel artificial membrane permeability assay (PAMPA), considering the impact of chitosan as a permeation enhancer. The MTT cytotoxicity assay demonstrates that the tested formulations (diluted 10-fold in HBSS pH 5.5) were non-toxic and well tolerated. An ocular itch test on mice was carried out with the formulation containing the combination of polymers comparable with a commercially available olopatadine eye drops without viscosity enhancers. The tested eye drops produced a slightly higher anti-pruritic/analgesic-like effect than the commercial preparation. It could be assumed that the use of this viscous ophthalmic vehicle due to its advanced mucoadhesive properties and good safety profile is a feasible strategy to improve the efficacy of olopatadine.",
publisher = "Elsevier B.V.",
journal = "European Journal of Pharmaceutical Sciences",
title = "Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches",
volume = "166",
doi = "10.1016/j.ejps.2021.105906"
}

Račić, A., Čalija, B., Milić, J., Jurišić Dukovski, B., Lovrić, J., Dobričić, V., Micov, A., Vuković, M., Stepanović-Petrović, R.,& Krajišnik, D.. (2021). Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches. in European Journal of Pharmaceutical Sciences
Elsevier B.V.., 166.
https://doi.org/10.1016/j.ejps.2021.105906

Račić A, Čalija B, Milić J, Jurišić Dukovski B, Lovrić J, Dobričić V, Micov A, Vuković M, Stepanović-Petrović R, Krajišnik D. Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches. in European Journal of Pharmaceutical Sciences. 2021;166.
doi:10.1016/j.ejps.2021.105906 .

Račić, Andjelka, Čalija, Bojan, Milić, Jela, Jurišić Dukovski, Bisera, Lovrić, Jasmina, Dobričić, Vladimir, Micov, Ana, Vuković, Milja, Stepanović-Petrović, Radica, Krajišnik, Danina, "Formulation of olopatadine hydrochloride viscous eye drops – physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches" in European Journal of Pharmaceutical Sciences, 166 (2021),
https://doi.org/10.1016/j.ejps.2021.105906 . .

TY  - CONF
AU  - Račić, Anđelka
AU  - Jurišić Dukovski, Bisera
AU  - Lovrić, Jasmina
AU  - Dobričić, Vladimir
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Krajišnik, Danina
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5481
AB  - Olopatadine is a selective H1-receptore antagonist that
inhibits release of histamine and proinflammatory
mediators [1]. The poor ocular bioavailability, as the main
limitation of efficient ocular therapy, could be overcome by
increasing residence time and enhancing corneal
penetration. ...
PB  - International Association for Pharmaceutical Technology, Mainz, Germany
C3  - 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11-14 May 2021, Vienna, Austria, Virtual meeting
T1  - Permeability and biocompatibility evaluation of olopatadine hydrochloride viscous ophthalmic solutions using in vitro 3D corneal model
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5481
ER  - 

@conference{
author = "Račić, Anđelka and Jurišić Dukovski, Bisera and Lovrić, Jasmina and Dobričić, Vladimir and Čalija, Bojan and Milić, Jela and Krajišnik, Danina",
year = "2021",
abstract = "Olopatadine is a selective H1-receptore antagonist that
inhibits release of histamine and proinflammatory
mediators [1]. The poor ocular bioavailability, as the main
limitation of efficient ocular therapy, could be overcome by
increasing residence time and enhancing corneal
penetration. ...",
publisher = "International Association for Pharmaceutical Technology, Mainz, Germany",
journal = "12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11-14 May 2021, Vienna, Austria, Virtual meeting",
title = "Permeability and biocompatibility evaluation of olopatadine hydrochloride viscous ophthalmic solutions using in vitro 3D corneal model",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5481"
}

Račić, A., Jurišić Dukovski, B., Lovrić, J., Dobričić, V., Čalija, B., Milić, J.,& Krajišnik, D.. (2021). Permeability and biocompatibility evaluation of olopatadine hydrochloride viscous ophthalmic solutions using in vitro 3D corneal model. in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11-14 May 2021, Vienna, Austria, Virtual meeting
International Association for Pharmaceutical Technology, Mainz, Germany..
https://hdl.handle.net/21.15107/rcub_farfar_5481

Račić A, Jurišić Dukovski B, Lovrić J, Dobričić V, Čalija B, Milić J, Krajišnik D. Permeability and biocompatibility evaluation of olopatadine hydrochloride viscous ophthalmic solutions using in vitro 3D corneal model. in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11-14 May 2021, Vienna, Austria, Virtual meeting. 2021;.
https://hdl.handle.net/21.15107/rcub_farfar_5481 .

Račić, Anđelka, Jurišić Dukovski, Bisera, Lovrić, Jasmina, Dobričić, Vladimir, Čalija, Bojan, Milić, Jela, Krajišnik, Danina, "Permeability and biocompatibility evaluation of olopatadine hydrochloride viscous ophthalmic solutions using in vitro 3D corneal model" in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 11-14 May 2021, Vienna, Austria, Virtual meeting (2021),
https://hdl.handle.net/21.15107/rcub_farfar_5481 .

TY  - JOUR
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Milašinović, Nikola
AU  - Daković, Aleksandra
AU  - Trifković, Kata
AU  - Stojanović, Jovica
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3478
AB  - This study was designed to investigate functionality of tetracycline‐loaded chitosan‐halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT‐IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan‐halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality‐related characteristic of chitosan‐halloysite nanocomposite films as potential sustained‐release carriers for topical delivery of antibiotics
PB  - Wiley Periodicals, Inc.
T2  - Journal of Applied Polymer Science
T1  - Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass
VL  - 137
IS  - 8
DO  - 10.1002/app.48406
ER  - 

@article{
author = "Čalija, Bojan and Milić, Jela and Milašinović, Nikola and Daković, Aleksandra and Trifković, Kata and Stojanović, Jovica",
year = "2020",
abstract = "This study was designed to investigate functionality of tetracycline‐loaded chitosan‐halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT‐IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan‐halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality‐related characteristic of chitosan‐halloysite nanocomposite films as potential sustained‐release carriers for topical delivery of antibiotics",
publisher = "Wiley Periodicals, Inc.",
journal = "Journal of Applied Polymer Science",
title = "Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass",
volume = "137",
number = "8",
doi = "10.1002/app.48406"
}

Čalija, B., Milić, J., Milašinović, N., Daković, A., Trifković, K.,& Stojanović, J.. (2020). Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science
Wiley Periodicals, Inc.., 137(8).
https://doi.org/10.1002/app.48406

Čalija B, Milić J, Milašinović N, Daković A, Trifković K, Stojanović J. Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science. 2020;137(8).
doi:10.1002/app.48406 .

Čalija, Bojan, Milić, Jela, Milašinović, Nikola, Daković, Aleksandra, Trifković, Kata, Stojanović, Jovica, "Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass" in Journal of Applied Polymer Science, 137, no. 8 (2020),
https://doi.org/10.1002/app.48406 . .

TY  - JOUR
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Milašinović, Nikola
AU  - Daković, Aleksandra
AU  - Trifković, Kata
AU  - Stojanović, Jovica
AU  - Krajišnik, Danina
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3476
AB  - This study was designed to investigate functionality of tetracycline‐loaded chitosan‐halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT‐IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan‐halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality‐related characteristic of chitosan‐halloysite nanocomposite films as potential sustained‐release carriers for topical delivery of antibiotics.
PB  - Wiley Periodicals, Inc.
T2  - Journal of Applied Polymer Science
T1  - Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass
VL  - 137
IS  - 8
DO  - 10.1002/app.48406
ER  - 

@article{
author = "Čalija, Bojan and Milić, Jela and Milašinović, Nikola and Daković, Aleksandra and Trifković, Kata and Stojanović, Jovica and Krajišnik, Danina",
year = "2020",
abstract = "This study was designed to investigate functionality of tetracycline‐loaded chitosan‐halloysite nanocomposite films, with focus on evaluating the influence of chitosan molar mass on films applicability for sustained local antibiotic delivery. The films were prepared by casting and solvent evaporation using low, medium, and high molar mass chitosan. SEM analysis revealed compact, nonporous and rough surface of the nanocomposite films due to the presence of halloysite agglomerates and tetracycline crystals. Increasing chitosan molar mass led to higher values of elongation at break (from 21.65 ± 2.65 to 34.48 ± 2.34%), tensile strength (from 134.8 ± 13.21 to 246.36 ± 14.69 MPa), and elastic modulus (from 633.79 ± 128.37 to 716.55 ± 60.76 MPa) of the nanocomposite films. FT‐IR, XRPD, and thermal analyses confirmed molar mass dependent chitosan‐halloysite interactions and improved thermal stability of the nanocomposite films in comparison with chitosan films. The nanocomposite films released tetracycline in a sustained manner, with the slowest release achieved from the films consisting of low molar mass chitosan. Chitosan molar mass was confirmed to be a functionality‐related characteristic of chitosan‐halloysite nanocomposite films as potential sustained‐release carriers for topical delivery of antibiotics.",
publisher = "Wiley Periodicals, Inc.",
journal = "Journal of Applied Polymer Science",
title = "Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass",
volume = "137",
number = "8",
doi = "10.1002/app.48406"
}

Čalija, B., Milić, J., Milašinović, N., Daković, A., Trifković, K., Stojanović, J.,& Krajišnik, D.. (2020). Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science
Wiley Periodicals, Inc.., 137(8).
https://doi.org/10.1002/app.48406

Čalija B, Milić J, Milašinović N, Daković A, Trifković K, Stojanović J, Krajišnik D. Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass. in Journal of Applied Polymer Science. 2020;137(8).
doi:10.1002/app.48406 .

Čalija, Bojan, Milić, Jela, Milašinović, Nikola, Daković, Aleksandra, Trifković, Kata, Stojanović, Jovica, Krajišnik, Danina, "Functionality of chitosan‐halloysite nanocomposite films for sustained delivery of antibiotics: The effect of chitosan molar mass" in Journal of Applied Polymer Science, 137, no. 8 (2020),
https://doi.org/10.1002/app.48406 . .

TY  - CONF
AU  - Račić, Anđelka
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Dobričić, Vladimir
AU  - Krajišnik, Danina
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5480
AB  - Ketotifen hidrogenfumarat (KF) je selektivni, nekompetitivni antagonist histamina (H1-
receptori) koji se koristi u lokalnoj terapiji alergijskog rinitisa i konjuktivitisa. Hitozan (H)
i hidroksipropil guar guma (HP GG) su biokompatibilni i biodegradabilni polimeri koji u
oftalmološkim preparatima zahvaljujući povećanju viskoziteta i mukoadhezivnim osobinama,
omogućavaju duži kontakt aktivne supstance sa rožnjačom i poboljšanje bioraspoloživosti.
Cilj ove studije bila su formulaciona i funkcionalna ispitivanja rastvora KF (0,025% m/v) za
oftalmološku primjenu koji sadrže H srednje molekulske mase (0,5% m/v) (uzorak F1), HP GG
(0,25% m/v) (uzorak F2) i njihovu kombinaciju (0,25 % m/v H/0,25% m/v HP GG) (uzorak F3) kao
modifikatore viskoziteta. Oftalmološki rastvori su pripremljeni miješanjem vehikuluma koji su
sadržavali polisaharide i pomoćne supstance (dibazni natrijum-fosfat, boraks i benzalkonijum-
hlorid) sa vodenim rastvorima KF. Izrađenim uzorcima ispitana je pH vrijednost, bistrina,
osmolalnost i sadržaj ljekovite supstance. Reološka karakterizacija sprovedena je na svježim
uzorcima na 20 °C i 34 °C (nakon razblaživanja sa vještačkom suznom tečnosti (VST) u odnosu
40:7) prije i nakon sterilizacije vodenom parom pod pritiskom. Sadržaj KF analiziran je HPLC
metodom.
Za sve ispitivane formulacije pH vrijednost, bistrina i osmolalnost bili su u prihvatljivom opsegu
za oftalmološke preparate. Vrijednosti viskoziteta (pri 20 ºC/100 s-1) bile su u opsegu od 13,2
mPa·s (F1) do 21 mPa·s (F3). Nakon razblaživanja sa VST i procesa sterilizacije, promjene
viskoziteta bile su manje od ±10% u odnosu na početne vrijednosti, za sve ispitivane formulacije.
Sadržaj KF nakon tri mjeseca bio je u opsegu 88-100% kod sterilisanih i nesterilisanih uzoraka.
Uspješno su formulisani viskozni rastvori KF za oftalmološku primjenu koji sadrže modifikatore
viskoziteta tipa polisaharida. Reproduktivni HPLC rezultati ukazuju na stabilnost KF i nakon
sterilizacije. Buduća istraživanja imaće za cilj ispitivanje lijek-polimer interakcija, uticaja izbora
pomoćnih supstanci kao i postupka izrade na funkcionalne karakteristike i stabilnost ispitivanih
rastvora za oftalmološku primjenu.
AB  - Ketotifen hydrogen fumarate (KF) is a selective and non-competitive histamine antagonist (H1-receptor) used topically in the treatment of allergic rhinitis and conjunctivitis. Chitosan (CH) and hydroxypropyl guar gum (HP GG), biocompatible and biodegradable polymers as mucoadhesive and viscosity increasing agents in ophthalmic products enable longer contact of active ingredient and the corneal surface, enhancing its bioavailability. The purpose of this study was formulation and functionality assessment of KF ophthalmic solutions (0.025% w/v) containing medium molecular weight CH (0.5% w/v) (sample F1), HP GG (0.25% w/v) (sample F2) and their combination (0.25% w/v CH/0.25% w/v HP GG) (sample F3) as viscosity modifiers. The ophthalmic solutions were prepared by mixing of solutions containing these polysaccharides, auxiliary substances (dibasic sodium phosphate, borax and benzalkonium chloride) and aqueous solutions of KF. The samples were evaluated for pH, clarity, osmolality and drug content. Rheological characterization was performed on fresh samples at 20 °C and 34 °C (after addition of simulated tear fluid (STF) in a ratio 40:7), before and after steam sterilization. The content of KF was analyzed by HPLC method. The pH, clarity and osmolality of all the tested formulations were within the acceptable range for ophthalmic preparations. The viscosity values (at 20 ºC/100 s-1) were in the range from 13.2 mPa·s (F1) to 21 mPa·s (F3). After dilution with STF and steam sterilization, changes of viscosity deviated less than ±10% compared with initial values for all tested vehicles. The drug content after 3 months was within range 88-100%, for both sterilized and non-sterilized samples. KF was successfully formulated in viscous ophthalmic solutions containing polysaccharidebased viscosity modifiers. Reproducible HPLC data revealed stability of KF after steam sterilization. Future research will be focused on investigations of drug-polymer interactions and influence of auxiliary substances selection alongside with preparation procedure on functional properties and ophthalmic solutions stability.
PB  - Prisma - korporativne komunikacije
PB  - Farmaceutska komora Crne Gore
C3  - Treći kongres farmaceuta Crne Gore sa međunarodnim učešćem, 09. - 12. maj 2019. godine, Budva, Bečići, Crna Gora, Knjiga sažetaka
T1  - Formulaciona i funkcionalna ispitivanja rastvora ketotifen-fumarata za oftalmološku primjenu sa polisaharidnim modifikatorima viskoziteta
T1  - Formulation and functionality assessment of ketotifen fumarate ophthalmic solutions containing polysaccharide-based viscosity modifiers
SP  - 192
EP  - 193
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5480
ER  - 

@conference{
author = "Račić, Anđelka and Čalija, Bojan and Milić, Jela and Dobričić, Vladimir and Krajišnik, Danina",
year = "2019",
abstract = "Ketotifen hidrogenfumarat (KF) je selektivni, nekompetitivni antagonist histamina (H1-
receptori) koji se koristi u lokalnoj terapiji alergijskog rinitisa i konjuktivitisa. Hitozan (H)
i hidroksipropil guar guma (HP GG) su biokompatibilni i biodegradabilni polimeri koji u
oftalmološkim preparatima zahvaljujući povećanju viskoziteta i mukoadhezivnim osobinama,
omogućavaju duži kontakt aktivne supstance sa rožnjačom i poboljšanje bioraspoloživosti.
Cilj ove studije bila su formulaciona i funkcionalna ispitivanja rastvora KF (0,025% m/v) za
oftalmološku primjenu koji sadrže H srednje molekulske mase (0,5% m/v) (uzorak F1), HP GG
(0,25% m/v) (uzorak F2) i njihovu kombinaciju (0,25 % m/v H/0,25% m/v HP GG) (uzorak F3) kao
modifikatore viskoziteta. Oftalmološki rastvori su pripremljeni miješanjem vehikuluma koji su
sadržavali polisaharide i pomoćne supstance (dibazni natrijum-fosfat, boraks i benzalkonijum-
hlorid) sa vodenim rastvorima KF. Izrađenim uzorcima ispitana je pH vrijednost, bistrina,
osmolalnost i sadržaj ljekovite supstance. Reološka karakterizacija sprovedena je na svježim
uzorcima na 20 °C i 34 °C (nakon razblaživanja sa vještačkom suznom tečnosti (VST) u odnosu
40:7) prije i nakon sterilizacije vodenom parom pod pritiskom. Sadržaj KF analiziran je HPLC
metodom.
Za sve ispitivane formulacije pH vrijednost, bistrina i osmolalnost bili su u prihvatljivom opsegu
za oftalmološke preparate. Vrijednosti viskoziteta (pri 20 ºC/100 s-1) bile su u opsegu od 13,2
mPa·s (F1) do 21 mPa·s (F3). Nakon razblaživanja sa VST i procesa sterilizacije, promjene
viskoziteta bile su manje od ±10% u odnosu na početne vrijednosti, za sve ispitivane formulacije.
Sadržaj KF nakon tri mjeseca bio je u opsegu 88-100% kod sterilisanih i nesterilisanih uzoraka.
Uspješno su formulisani viskozni rastvori KF za oftalmološku primjenu koji sadrže modifikatore
viskoziteta tipa polisaharida. Reproduktivni HPLC rezultati ukazuju na stabilnost KF i nakon
sterilizacije. Buduća istraživanja imaće za cilj ispitivanje lijek-polimer interakcija, uticaja izbora
pomoćnih supstanci kao i postupka izrade na funkcionalne karakteristike i stabilnost ispitivanih
rastvora za oftalmološku primjenu., Ketotifen hydrogen fumarate (KF) is a selective and non-competitive histamine antagonist (H1-receptor) used topically in the treatment of allergic rhinitis and conjunctivitis. Chitosan (CH) and hydroxypropyl guar gum (HP GG), biocompatible and biodegradable polymers as mucoadhesive and viscosity increasing agents in ophthalmic products enable longer contact of active ingredient and the corneal surface, enhancing its bioavailability. The purpose of this study was formulation and functionality assessment of KF ophthalmic solutions (0.025% w/v) containing medium molecular weight CH (0.5% w/v) (sample F1), HP GG (0.25% w/v) (sample F2) and their combination (0.25% w/v CH/0.25% w/v HP GG) (sample F3) as viscosity modifiers. The ophthalmic solutions were prepared by mixing of solutions containing these polysaccharides, auxiliary substances (dibasic sodium phosphate, borax and benzalkonium chloride) and aqueous solutions of KF. The samples were evaluated for pH, clarity, osmolality and drug content. Rheological characterization was performed on fresh samples at 20 °C and 34 °C (after addition of simulated tear fluid (STF) in a ratio 40:7), before and after steam sterilization. The content of KF was analyzed by HPLC method. The pH, clarity and osmolality of all the tested formulations were within the acceptable range for ophthalmic preparations. The viscosity values (at 20 ºC/100 s-1) were in the range from 13.2 mPa·s (F1) to 21 mPa·s (F3). After dilution with STF and steam sterilization, changes of viscosity deviated less than ±10% compared with initial values for all tested vehicles. The drug content after 3 months was within range 88-100%, for both sterilized and non-sterilized samples. KF was successfully formulated in viscous ophthalmic solutions containing polysaccharidebased viscosity modifiers. Reproducible HPLC data revealed stability of KF after steam sterilization. Future research will be focused on investigations of drug-polymer interactions and influence of auxiliary substances selection alongside with preparation procedure on functional properties and ophthalmic solutions stability.",
publisher = "Prisma - korporativne komunikacije, Farmaceutska komora Crne Gore",
journal = "Treći kongres farmaceuta Crne Gore sa međunarodnim učešćem, 09. - 12. maj 2019. godine, Budva, Bečići, Crna Gora, Knjiga sažetaka",
title = "Formulaciona i funkcionalna ispitivanja rastvora ketotifen-fumarata za oftalmološku primjenu sa polisaharidnim modifikatorima viskoziteta, Formulation and functionality assessment of ketotifen fumarate ophthalmic solutions containing polysaccharide-based viscosity modifiers",
pages = "192-193",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5480"
}

Račić, A., Čalija, B., Milić, J., Dobričić, V.,& Krajišnik, D.. (2019). Formulaciona i funkcionalna ispitivanja rastvora ketotifen-fumarata za oftalmološku primjenu sa polisaharidnim modifikatorima viskoziteta. in Treći kongres farmaceuta Crne Gore sa međunarodnim učešćem, 09. - 12. maj 2019. godine, Budva, Bečići, Crna Gora, Knjiga sažetaka
Prisma - korporativne komunikacije., 192-193.
https://hdl.handle.net/21.15107/rcub_farfar_5480

Račić A, Čalija B, Milić J, Dobričić V, Krajišnik D. Formulaciona i funkcionalna ispitivanja rastvora ketotifen-fumarata za oftalmološku primjenu sa polisaharidnim modifikatorima viskoziteta. in Treći kongres farmaceuta Crne Gore sa međunarodnim učešćem, 09. - 12. maj 2019. godine, Budva, Bečići, Crna Gora, Knjiga sažetaka. 2019;:192-193.
https://hdl.handle.net/21.15107/rcub_farfar_5480 .

Račić, Anđelka, Čalija, Bojan, Milić, Jela, Dobričić, Vladimir, Krajišnik, Danina, "Formulaciona i funkcionalna ispitivanja rastvora ketotifen-fumarata za oftalmološku primjenu sa polisaharidnim modifikatorima viskoziteta" in Treći kongres farmaceuta Crne Gore sa međunarodnim učešćem, 09. - 12. maj 2019. godine, Budva, Bečići, Crna Gora, Knjiga sažetaka (2019):192-193,
https://hdl.handle.net/21.15107/rcub_farfar_5480 .

TY  - JOUR
AU  - Čalija, Bojan
AU  - Krajišnik, Danina
AU  - Milić, Jela
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3651
AB  - Owing to its safety, wide distribution, and unique physicochemical properties, water is indispensable in pharmaceutical industry as excipient, solvent for extraction, production of active ingredients and analytical reagents, cleaning and heat-transfer agent. Various water types are used for production of pharmaceutical preparations and the water quality requirements depend on characteristics and use of final pharmaceutical preparation and production stage at which is water used. This paper summarizes regulatory requirements related to water for pharmaceutical use and systems for water production, storage and distribution in pharmaceutical industry, with focus on current regulation changes in this field. An overview on types of water for pharmaceutical use is provided, especially that official in The European and The United States Pharmacopoeia, including their quality requirements, usage and production methods.
AB  - Zahvaljujući bezbednosti, rasprostranjenosti i jedinstvenim fizičko-hemijskim osobinama, voda je nezamenjiva u farmaceutskoj industriji kao ekscipijens, sredstvo za proizvodnju aktivnih supstanci i analitičkih reagenasa, ekstrakciju, čišćenje/pranje i razmenu toplote. Vode različitog kvaliteta se koriste za proizvodnju farmaceutskih preparata, a zahtevani kvalitet vode definisan je osobinama i namenom finalnog farmaceutskog preparata i fazom u postupku njegove proizvodnje u kojoj se voda koristi. U ovom radu su predstavljeni regulatorni zahtevi za vode za farmaceutsku upotrebu i sisteme za proizvodnju, distribuciju i čuvanje vode u farmaceutskoj industriji, sa posebnim osvrtom na aktuelne izmene propisa u ovoj oblasti. Prikazan je i pregled voda za farmaceutsku upotrebu, sa fokusom na vode oficijalne u Evropskoj i Američkoj farmakopeji, uključujući zahteve za njihov kvalitet, namenu i postupke proizvodnje.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Watertypesfor pharmaceuticaland quality requirementsuse – importance
T1  - Voda za farmaceutsku upotrebu – značaj, vrste i zahtevi za kvalitet
T1  - Zahvaljujući bezbednosti, rasprostranjenosti i jedinstvenim fizičko-hemijskim osobinama, voda  je  nezamenjiva  u  farmaceutskoj  industriji  kao  ekscipijens,  sredstvo  za  proizvodnju aktivnih supstanci i analitičkih reagenasa, ekstrakciju, čišćenje/pranje i razmenu toplote. Vode različitog kvaliteta se koriste za proizvodnju farmaceutskih preparata, a zahtevani kvalitet vode definisan  je  osobinama  i  namenom  finalnog  farmaceutskog  preparata  i  fazom  u  postupku njegove proizvodnje u kojoj se voda koristi.  U  ovom  radu  su  predstavljeni  regulatorni  zahtevi za  vode  za  farmaceutsku  upotrebu  i sisteme  za  proizvodnju,  distribuciju  i  čuvanje  vode  u  farmaceutskoj  industriji,  sa  posebnim osvrtom na aktuelne izmene propisa u ovoj oblasti. Prikazan je i pregled voda za farmaceutsku upotrebu,  sa  fokusom  na  vode  oficinalne  u  Evropskoj  i  Američkoj  farmakopeji,  uključujući zahteve za njihov kvalitet, namenu i postupke proizvodnje.
VL  - 69
IS  - 2
SP  - 90
EP  - 115
DO  - 10.5937/arhfarm1902090Q
ER  - 

@article{
author = "Čalija, Bojan and Krajišnik, Danina and Milić, Jela",
year = "2019",
abstract = "Owing to its safety, wide distribution, and unique physicochemical properties, water is indispensable in pharmaceutical industry as excipient, solvent for extraction, production of active ingredients and analytical reagents, cleaning and heat-transfer agent. Various water types are used for production of pharmaceutical preparations and the water quality requirements depend on characteristics and use of final pharmaceutical preparation and production stage at which is water used. This paper summarizes regulatory requirements related to water for pharmaceutical use and systems for water production, storage and distribution in pharmaceutical industry, with focus on current regulation changes in this field. An overview on types of water for pharmaceutical use is provided, especially that official in The European and The United States Pharmacopoeia, including their quality requirements, usage and production methods., Zahvaljujući bezbednosti, rasprostranjenosti i jedinstvenim fizičko-hemijskim osobinama, voda je nezamenjiva u farmaceutskoj industriji kao ekscipijens, sredstvo za proizvodnju aktivnih supstanci i analitičkih reagenasa, ekstrakciju, čišćenje/pranje i razmenu toplote. Vode različitog kvaliteta se koriste za proizvodnju farmaceutskih preparata, a zahtevani kvalitet vode definisan je osobinama i namenom finalnog farmaceutskog preparata i fazom u postupku njegove proizvodnje u kojoj se voda koristi. U ovom radu su predstavljeni regulatorni zahtevi za vode za farmaceutsku upotrebu i sisteme za proizvodnju, distribuciju i čuvanje vode u farmaceutskoj industriji, sa posebnim osvrtom na aktuelne izmene propisa u ovoj oblasti. Prikazan je i pregled voda za farmaceutsku upotrebu, sa fokusom na vode oficijalne u Evropskoj i Američkoj farmakopeji, uključujući zahteve za njihov kvalitet, namenu i postupke proizvodnje.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Watertypesfor pharmaceuticaland quality requirementsuse – importance, Voda za farmaceutsku upotrebu – značaj, vrste i zahtevi za kvalitet, Zahvaljujući bezbednosti, rasprostranjenosti i jedinstvenim fizičko-hemijskim osobinama, voda  je  nezamenjiva  u  farmaceutskoj  industriji  kao  ekscipijens,  sredstvo  za  proizvodnju aktivnih supstanci i analitičkih reagenasa, ekstrakciju, čišćenje/pranje i razmenu toplote. Vode različitog kvaliteta se koriste za proizvodnju farmaceutskih preparata, a zahtevani kvalitet vode definisan  je  osobinama  i  namenom  finalnog  farmaceutskog  preparata  i  fazom  u  postupku njegove proizvodnje u kojoj se voda koristi.  U  ovom  radu  su  predstavljeni  regulatorni  zahtevi za  vode  za  farmaceutsku  upotrebu  i sisteme  za  proizvodnju,  distribuciju  i  čuvanje  vode  u  farmaceutskoj  industriji,  sa  posebnim osvrtom na aktuelne izmene propisa u ovoj oblasti. Prikazan je i pregled voda za farmaceutsku upotrebu,  sa  fokusom  na  vode  oficinalne  u  Evropskoj  i  Američkoj  farmakopeji,  uključujući zahteve za njihov kvalitet, namenu i postupke proizvodnje.",
volume = "69",
number = "2",
pages = "90-115",
doi = "10.5937/arhfarm1902090Q"
}

Čalija, B., Krajišnik, D.,& Milić, J.. (2019). Watertypesfor pharmaceuticaland quality requirementsuse – importance. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 69(2), 90-115.
https://doi.org/10.5937/arhfarm1902090Q

Čalija B, Krajišnik D, Milić J. Watertypesfor pharmaceuticaland quality requirementsuse – importance. in Arhiv za farmaciju. 2019;69(2):90-115.
doi:10.5937/arhfarm1902090Q .

Čalija, Bojan, Krajišnik, Danina, Milić, Jela, "Watertypesfor pharmaceuticaland quality requirementsuse – importance" in Arhiv za farmaciju, 69, no. 2 (2019):90-115,
https://doi.org/10.5937/arhfarm1902090Q . .

TY  - JOUR
AU  - Krajišnik, Danina
AU  - Milić, Jela
AU  - Savić, Snežana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3490
AB  - Parenteralnim  putem  se  primenjuju  različiti  tipovi  farmaceutskih  preparata  čiji  sastav može  biti  jednostavan  (vodeni  rastvori)  i  manje  ili  više  kompleksan  (emulzije,  suspenzije, liposomi kao nosači lekovitih supstanci, čestični sistemi, čvrsti implanti/implantati). Napredak u bio-  i  nanotehnologiji  omogućio  je  razvoj  nove  klase  kompleksnih  lekova,  bioloških  i  tzv. nebioloških  kompleksnih  lekova  (i  njihovih  „similara”-  sličnih lekova),  čiji  dalji  razvoj  se očekuje u bliskoj budućnosti, a  koji se, u velikom broju slučajeva, primenjuju parenteralnim putem.  Parenteralni preparati koji u svom sastavu sadrže lekovite supstance koje su inkapsulirane u nosače tipa liposoma predstavljaju nebiološke kompleksne lekove koji su do sada najduže u upotrebi i čije su osobine i definisana svojstva kvaliteta najviše ispitivana. U radu je dat pregled obaveznih  i  dodatnih  (specifičnih) in  vitro  ispitivanja  liposomskih  nosača  lekovitih supstanci za primenu parenteralnim putem. Činjenica da postupci izvođenja ovih ispitivanja u  osnovi  nisu  propisani  u  relevantnim  farmakopejama  (Ph.  Eur., USP  i  JP)  i  da  se  mogu značajno razlikovati između laboratorija, doprinosi velikoj varijabilnosti dobijenih rezultata i ograničenjima u njihovom međusobnom poređenju. Regulatorna tela EMA i FDA učestvovala su u pripremi određenih dokumenata i razvoju odgovarajućih standarda i smernica u pogledu ispitivanja  kvaliteta  farmaceutskih  oblika  sa  liposomskim  nosačima  lekovitih  supstanci  za parenteralnu primenu.
AB  - A greater variety of pharmaceutical preparations can be administered by the parenteral route, the composition of which can be simple (aqueous solutions) and more or less complex (emulsions,  suspensions,  liposomes  as  carriers  of  active  pharmaceutical  ingredients,  particle systems,  solid  implants/implants).  In  addition,  advances  in  bio-  and  nano-  technology  have enabled the development of new classes of complex drugs, so-called non-biological complex drugs (and their similars) whose further development is expected in the near future, and which are in many cases applied by parenteral route.  Parenteral preparations containing active substances encapsulated in the liposome-type carriers represent a class of non-biological complex drugs which have the longest use so far and whose properties and defined quality characteristics are being most examined. In this paper, an overview  of  mandatory  and  additional  (specific) in  vitro  tests  for  parenteral  liposomal  drug carriers is presented. The fact that standard testing procedures are often not available in relevant pharmacopoeias  (Ph.  Eur.,  USP  and  JP),  so  that  they  can  vary  significantly  between laboratories, contributes to the great variability of the results obtained and constraints in their mutual  comparison.  EMA  and  FDA,  as  regulatory  agencies,  have  also  participated  in  the preparation of certain documents and development of appropriate standards and guidelines for quality control of liposomal drug carriers for parenteral application.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Izazovi in vitro karakterizacije nebioloških kompleksnih lekova - primer parenteralnih preparata sa liposomskim nosačima lekovitih supstanci
T1  - Challenges of in vitro characterization of non-biological complex drugs - example of parenteral preparations with liposomal drug carriers
VL  - 69
IS  - 3
SP  - 176
EP  - 198
DO  - 10.5937/arhfarm1903176K
ER  - 

@article{
author = "Krajišnik, Danina and Milić, Jela and Savić, Snežana",
year = "2019",
abstract = "Parenteralnim  putem  se  primenjuju  različiti  tipovi  farmaceutskih  preparata  čiji  sastav može  biti  jednostavan  (vodeni  rastvori)  i  manje  ili  više  kompleksan  (emulzije,  suspenzije, liposomi kao nosači lekovitih supstanci, čestični sistemi, čvrsti implanti/implantati). Napredak u bio-  i  nanotehnologiji  omogućio  je  razvoj  nove  klase  kompleksnih  lekova,  bioloških  i  tzv. nebioloških  kompleksnih  lekova  (i  njihovih  „similara”-  sličnih lekova),  čiji  dalji  razvoj  se očekuje u bliskoj budućnosti, a  koji se, u velikom broju slučajeva, primenjuju parenteralnim putem.  Parenteralni preparati koji u svom sastavu sadrže lekovite supstance koje su inkapsulirane u nosače tipa liposoma predstavljaju nebiološke kompleksne lekove koji su do sada najduže u upotrebi i čije su osobine i definisana svojstva kvaliteta najviše ispitivana. U radu je dat pregled obaveznih  i  dodatnih  (specifičnih) in  vitro  ispitivanja  liposomskih  nosača  lekovitih supstanci za primenu parenteralnim putem. Činjenica da postupci izvođenja ovih ispitivanja u  osnovi  nisu  propisani  u  relevantnim  farmakopejama  (Ph.  Eur., USP  i  JP)  i  da  se  mogu značajno razlikovati između laboratorija, doprinosi velikoj varijabilnosti dobijenih rezultata i ograničenjima u njihovom međusobnom poređenju. Regulatorna tela EMA i FDA učestvovala su u pripremi određenih dokumenata i razvoju odgovarajućih standarda i smernica u pogledu ispitivanja  kvaliteta  farmaceutskih  oblika  sa  liposomskim  nosačima  lekovitih  supstanci  za parenteralnu primenu., A greater variety of pharmaceutical preparations can be administered by the parenteral route, the composition of which can be simple (aqueous solutions) and more or less complex (emulsions,  suspensions,  liposomes  as  carriers  of  active  pharmaceutical  ingredients,  particle systems,  solid  implants/implants).  In  addition,  advances  in  bio-  and  nano-  technology  have enabled the development of new classes of complex drugs, so-called non-biological complex drugs (and their similars) whose further development is expected in the near future, and which are in many cases applied by parenteral route.  Parenteral preparations containing active substances encapsulated in the liposome-type carriers represent a class of non-biological complex drugs which have the longest use so far and whose properties and defined quality characteristics are being most examined. In this paper, an overview  of  mandatory  and  additional  (specific) in  vitro  tests  for  parenteral  liposomal  drug carriers is presented. The fact that standard testing procedures are often not available in relevant pharmacopoeias  (Ph.  Eur.,  USP  and  JP),  so  that  they  can  vary  significantly  between laboratories, contributes to the great variability of the results obtained and constraints in their mutual  comparison.  EMA  and  FDA,  as  regulatory  agencies,  have  also  participated  in  the preparation of certain documents and development of appropriate standards and guidelines for quality control of liposomal drug carriers for parenteral application.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Izazovi in vitro karakterizacije nebioloških kompleksnih lekova - primer parenteralnih preparata sa liposomskim nosačima lekovitih supstanci, Challenges of in vitro characterization of non-biological complex drugs - example of parenteral preparations with liposomal drug carriers",
volume = "69",
number = "3",
pages = "176-198",
doi = "10.5937/arhfarm1903176K"
}

Krajišnik, D., Milić, J.,& Savić, S.. (2019). Izazovi in vitro karakterizacije nebioloških kompleksnih lekova - primer parenteralnih preparata sa liposomskim nosačima lekovitih supstanci. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 69(3), 176-198.
https://doi.org/10.5937/arhfarm1903176K

Krajišnik D, Milić J, Savić S. Izazovi in vitro karakterizacije nebioloških kompleksnih lekova - primer parenteralnih preparata sa liposomskim nosačima lekovitih supstanci. in Arhiv za farmaciju. 2019;69(3):176-198.
doi:10.5937/arhfarm1903176K .

Krajišnik, Danina, Milić, Jela, Savić, Snežana, "Izazovi in vitro karakterizacije nebioloških kompleksnih lekova - primer parenteralnih preparata sa liposomskim nosačima lekovitih supstanci" in Arhiv za farmaciju, 69, no. 3 (2019):176-198,
https://doi.org/10.5937/arhfarm1903176K . .

TY  - JOUR
AU  - Dragičević, Nina
AU  - Krajišnik, Danina
AU  - Milić, Jela
AU  - Fahr, Alfred
AU  - Maibach, Howard
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3319
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3438
AB  - Objective: The aim of this study was to develop, characterize and evaluate stability of a gel containing coenzyme Q(10) (Q(10))-loaded liposomes, and enhance the stability of Q(10) in the nanocarrier-containing gel compared to the conventional gel. Methods: Q(10)-loaded liposome dispersions prepared from unsaturated or saturated lecithin, were characterized for particle size, polydispersity index (PDI), zeta-potential, pH value, oxidation index, Q(10)-content and morphology, and incorporated into carbomer gel. Liposome gels and liposome-free gel were analyzed for flow properties, pH values, Q(10)-content, and liposomes size and PDI (liposome gels), 48 h after preparation and in predetermined time intervals during 6 months storage at different temperatures in order to predict their long term stability. Results: Liposomes were of small particle size, homogeneous, negatively charged, and their incorporation into gel did not significantly change (p > .05) their particle size and PDI. All gels revealed non-Newtonian, shear-thinning plastic flow behavior during storage with no marked changes in rheological parameters. Storage of gels did not significantly influence the pH value (p > .05), while it significantly decreased Q(10)-content (p  lt  .05). Q(10) was significantly more (p  lt  .05) stable in liposome gel containing unsaturated lecithin liposomes (G1) than in gel containing saturated lecithin liposomes (G2) and liposome-free gel (G3). Conclusions: Q(10)-loaded liposome gel G1 was the optimal formulation, since during storage at different temperatures, it did not show significant increase in liposome size and PDI, it provided significantly higher stability for Q(10) than other gels and its pH value was suitable for skin application. Due to limited Q(10)-stability it should be stored at 4 degrees C.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Development and Industrial Pharmacy
T1  - Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements
VL  - 45
IS  - 1
SP  - 43
EP  - 54
DO  - 10.1080/03639045.2018.1515220
ER  - 

@article{
author = "Dragičević, Nina and Krajišnik, Danina and Milić, Jela and Fahr, Alfred and Maibach, Howard",
year = "2019",
abstract = "Objective: The aim of this study was to develop, characterize and evaluate stability of a gel containing coenzyme Q(10) (Q(10))-loaded liposomes, and enhance the stability of Q(10) in the nanocarrier-containing gel compared to the conventional gel. Methods: Q(10)-loaded liposome dispersions prepared from unsaturated or saturated lecithin, were characterized for particle size, polydispersity index (PDI), zeta-potential, pH value, oxidation index, Q(10)-content and morphology, and incorporated into carbomer gel. Liposome gels and liposome-free gel were analyzed for flow properties, pH values, Q(10)-content, and liposomes size and PDI (liposome gels), 48 h after preparation and in predetermined time intervals during 6 months storage at different temperatures in order to predict their long term stability. Results: Liposomes were of small particle size, homogeneous, negatively charged, and their incorporation into gel did not significantly change (p > .05) their particle size and PDI. All gels revealed non-Newtonian, shear-thinning plastic flow behavior during storage with no marked changes in rheological parameters. Storage of gels did not significantly influence the pH value (p > .05), while it significantly decreased Q(10)-content (p  lt  .05). Q(10) was significantly more (p  lt  .05) stable in liposome gel containing unsaturated lecithin liposomes (G1) than in gel containing saturated lecithin liposomes (G2) and liposome-free gel (G3). Conclusions: Q(10)-loaded liposome gel G1 was the optimal formulation, since during storage at different temperatures, it did not show significant increase in liposome size and PDI, it provided significantly higher stability for Q(10) than other gels and its pH value was suitable for skin application. Due to limited Q(10)-stability it should be stored at 4 degrees C.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements",
volume = "45",
number = "1",
pages = "43-54",
doi = "10.1080/03639045.2018.1515220"
}

Dragičević, N., Krajišnik, D., Milić, J., Fahr, A.,& Maibach, H.. (2019). Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 45(1), 43-54.
https://doi.org/10.1080/03639045.2018.1515220

Dragičević N, Krajišnik D, Milić J, Fahr A, Maibach H. Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements. in Drug Development and Industrial Pharmacy. 2019;45(1):43-54.
doi:10.1080/03639045.2018.1515220 .

Dragičević, Nina, Krajišnik, Danina, Milić, Jela, Fahr, Alfred, Maibach, Howard, "Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements" in Drug Development and Industrial Pharmacy, 45, no. 1 (2019):43-54,
https://doi.org/10.1080/03639045.2018.1515220 . .

TY  - JOUR
AU  - Račić, Anđelka
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Milasinvić, Nikola
AU  - Krajišnik, Danina
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3330
AB  - Incorporation of mucoadhesive polymers is one of the first efficient modification of conventional liquid ophthalmic formulations in order to prolong the residence time at ocular surface. The aim of this work was formulation of viscous ophthalmic vehicles/ocular lubricants containing derivative of guar gum, chitosan and cellulose derivatives (hypromellose and hydroxyethylcellulose) alone or in combination. Optimized formulations were developed by choosing appropriate polymer or combination of polymers in suitable concentrations with adequate physicochemical, rheological and mucoadhesive properties. Influence of the addition of simulated tear fluid, steam sterilization and storage on clarity, pH value and rheological properties of different formulations were evaluated. The compounded vehicles were compared with commercially available ocular lubricants containing similar polymers. It was observed that viscosities of commercially available eye drops were above the optimal viscosity range. The mucoadhesive potential of the vehicles, rheological synergism and type of polymermucin interaction were determined. Combination of chitosan and guar gum exhibited optimal physicochemical, rheological and mucoadhesive properties and had a potential for the longest retention time in tear film. Considering the simplicity of its preparation and stability (over a period of one-month storage), this vehicle could be used for extemporaneously compounded ocular preparations for specific needs of individual patients.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Drug Delivery Science and Technology
T1  - Development of polysaccharide-based mucoadhesive ophthalmic lubricating vehicles: The effect of different polymers on physicochemical properties and functionality
VL  - 49
SP  - 50
EP  - 57
DO  - 10.1016/j.jddst.2018.10.034
ER  - 

@article{
author = "Račić, Anđelka and Čalija, Bojan and Milić, Jela and Milasinvić, Nikola and Krajišnik, Danina",
year = "2019",
abstract = "Incorporation of mucoadhesive polymers is one of the first efficient modification of conventional liquid ophthalmic formulations in order to prolong the residence time at ocular surface. The aim of this work was formulation of viscous ophthalmic vehicles/ocular lubricants containing derivative of guar gum, chitosan and cellulose derivatives (hypromellose and hydroxyethylcellulose) alone or in combination. Optimized formulations were developed by choosing appropriate polymer or combination of polymers in suitable concentrations with adequate physicochemical, rheological and mucoadhesive properties. Influence of the addition of simulated tear fluid, steam sterilization and storage on clarity, pH value and rheological properties of different formulations were evaluated. The compounded vehicles were compared with commercially available ocular lubricants containing similar polymers. It was observed that viscosities of commercially available eye drops were above the optimal viscosity range. The mucoadhesive potential of the vehicles, rheological synergism and type of polymermucin interaction were determined. Combination of chitosan and guar gum exhibited optimal physicochemical, rheological and mucoadhesive properties and had a potential for the longest retention time in tear film. Considering the simplicity of its preparation and stability (over a period of one-month storage), this vehicle could be used for extemporaneously compounded ocular preparations for specific needs of individual patients.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Drug Delivery Science and Technology",
title = "Development of polysaccharide-based mucoadhesive ophthalmic lubricating vehicles: The effect of different polymers on physicochemical properties and functionality",
volume = "49",
pages = "50-57",
doi = "10.1016/j.jddst.2018.10.034"
}

Račić, A., Čalija, B., Milić, J., Milasinvić, N.,& Krajišnik, D.. (2019). Development of polysaccharide-based mucoadhesive ophthalmic lubricating vehicles: The effect of different polymers on physicochemical properties and functionality. in Journal of Drug Delivery Science and Technology
Elsevier Science BV, Amsterdam., 49, 50-57.
https://doi.org/10.1016/j.jddst.2018.10.034

Račić A, Čalija B, Milić J, Milasinvić N, Krajišnik D. Development of polysaccharide-based mucoadhesive ophthalmic lubricating vehicles: The effect of different polymers on physicochemical properties and functionality. in Journal of Drug Delivery Science and Technology. 2019;49:50-57.
doi:10.1016/j.jddst.2018.10.034 .

Račić, Anđelka, Čalija, Bojan, Milić, Jela, Milasinvić, Nikola, Krajišnik, Danina, "Development of polysaccharide-based mucoadhesive ophthalmic lubricating vehicles: The effect of different polymers on physicochemical properties and functionality" in Journal of Drug Delivery Science and Technology, 49 (2019):50-57,
https://doi.org/10.1016/j.jddst.2018.10.034 . .

TY  - JOUR
AU  - Dragičević, Nina
AU  - Krajišnik, Danina
AU  - Milić, Jela
AU  - Fahr, Alfred
AU  - Maibach, Howard
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3319
AB  - Objective: The aim of this study was to develop, characterize and evaluate stability of a gel containing coenzyme Q(10) (Q(10))-loaded liposomes, and enhance the stability of Q(10) in the nanocarrier-containing gel compared to the conventional gel. Methods: Q(10)-loaded liposome dispersions prepared from unsaturated or saturated lecithin, were characterized for particle size, polydispersity index (PDI), zeta-potential, pH value, oxidation index, Q(10)-content and morphology, and incorporated into carbomer gel. Liposome gels and liposome-free gel were analyzed for flow properties, pH values, Q(10)-content, and liposomes size and PDI (liposome gels), 48 h after preparation and in predetermined time intervals during 6 months storage at different temperatures in order to predict their long term stability. Results: Liposomes were of small particle size, homogeneous, negatively charged, and their incorporation into gel did not significantly change (p > .05) their particle size and PDI. All gels revealed non-Newtonian, shear-thinning plastic flow behavior during storage with no marked changes in rheological parameters. Storage of gels did not significantly influence the pH value (p > .05), while it significantly decreased Q(10)-content (p  lt  .05). Q(10) was significantly more (p  lt  .05) stable in liposome gel containing unsaturated lecithin liposomes (G1) than in gel containing saturated lecithin liposomes (G2) and liposome-free gel (G3). Conclusions: Q(10)-loaded liposome gel G1 was the optimal formulation, since during storage at different temperatures, it did not show significant increase in liposome size and PDI, it provided significantly higher stability for Q(10) than other gels and its pH value was suitable for skin application. Due to limited Q(10)-stability it should be stored at 4 degrees C.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Drug Development and Industrial Pharmacy
T1  - Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements
VL  - 45
IS  - 1
SP  - 43
EP  - 54
DO  - 10.1080/03639045.2018.1515220
ER  - 

@article{
author = "Dragičević, Nina and Krajišnik, Danina and Milić, Jela and Fahr, Alfred and Maibach, Howard",
year = "2019",
abstract = "Objective: The aim of this study was to develop, characterize and evaluate stability of a gel containing coenzyme Q(10) (Q(10))-loaded liposomes, and enhance the stability of Q(10) in the nanocarrier-containing gel compared to the conventional gel. Methods: Q(10)-loaded liposome dispersions prepared from unsaturated or saturated lecithin, were characterized for particle size, polydispersity index (PDI), zeta-potential, pH value, oxidation index, Q(10)-content and morphology, and incorporated into carbomer gel. Liposome gels and liposome-free gel were analyzed for flow properties, pH values, Q(10)-content, and liposomes size and PDI (liposome gels), 48 h after preparation and in predetermined time intervals during 6 months storage at different temperatures in order to predict their long term stability. Results: Liposomes were of small particle size, homogeneous, negatively charged, and their incorporation into gel did not significantly change (p > .05) their particle size and PDI. All gels revealed non-Newtonian, shear-thinning plastic flow behavior during storage with no marked changes in rheological parameters. Storage of gels did not significantly influence the pH value (p > .05), while it significantly decreased Q(10)-content (p  lt  .05). Q(10) was significantly more (p  lt  .05) stable in liposome gel containing unsaturated lecithin liposomes (G1) than in gel containing saturated lecithin liposomes (G2) and liposome-free gel (G3). Conclusions: Q(10)-loaded liposome gel G1 was the optimal formulation, since during storage at different temperatures, it did not show significant increase in liposome size and PDI, it provided significantly higher stability for Q(10) than other gels and its pH value was suitable for skin application. Due to limited Q(10)-stability it should be stored at 4 degrees C.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Drug Development and Industrial Pharmacy",
title = "Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements",
volume = "45",
number = "1",
pages = "43-54",
doi = "10.1080/03639045.2018.1515220"
}

Dragičević, N., Krajišnik, D., Milić, J., Fahr, A.,& Maibach, H.. (2019). Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements. in Drug Development and Industrial Pharmacy
Taylor & Francis Ltd, Abingdon., 45(1), 43-54.
https://doi.org/10.1080/03639045.2018.1515220

Dragičević N, Krajišnik D, Milić J, Fahr A, Maibach H. Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements. in Drug Development and Industrial Pharmacy. 2019;45(1):43-54.
doi:10.1080/03639045.2018.1515220 .

Dragičević, Nina, Krajišnik, Danina, Milić, Jela, Fahr, Alfred, Maibach, Howard, "Development of hydrophilic gels containing coenzyme Q(10)-loaded liposomes: characterization, stability and rheology measurements" in Drug Development and Industrial Pharmacy, 45, no. 1 (2019):43-54,
https://doi.org/10.1080/03639045.2018.1515220 . .

TY  - JOUR
AU  - Dragičević, Nina
AU  - Krajišnik, Danina
AU  - Milić, Jela
AU  - Pecarski, D
AU  - Jugović, Z
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3283
AB  - The aim of this study was to develop a semisolid formulation containing liposomes loaded with coenzyme Q10 (Q10). Q10-loaded liposome dispersion prepared from non-hydrogenated lecithin and characterized for particle size, polydispersity index (PDI), pH value and Q10-content was incorporated into carbomer gel, and a liposome gel was obtained. Liposome gel and liposome-free gel were analyzed for flow properties by continuous rheology measurements, pH values and Q10-content, 48 h after preparation and after a temperature stress test (1 cycle: 24 h at 4 o C, 24 h at 20±2 o C and 24 h at 40 o C), in order to predict their long-term stability. Liposomes were identified in liposome dispersion and liposome gel by freeze fracture electron microscopy (FFEM), while their particle size, PDI and zeta potential were determined by photon correlation spectroscopy (PCS). Q10-loaded liposomes were of small particle size (125 nm), homogeneous (PDI=0.2) and negatively charged, and their incorporation into the gel did not significantly change (p&0.05) their particle size and PDI. FFEM confirmed liposomes presence in the liposome gel. Liposome and liposome-free gel revealed non-Newtonian, shear-thinning plastic flow behavior. The temperature stress test revealed that temperature changes did not significantly influence (p&0.05) the pH value, while they significantly decreased (p&0.05) Q10-content in gels. Q10 was significantly more stable (p&0.05) in liposome gel than in liposome-free gel. Rheological parameters of liposome-free gel significantly changed, in contrast to the liposome gel. In conclusion, Q10-loaded liposome gel suitable for dermal use was developed, exhibiting high stability even after subjecting to the temperature stress test.
PB  - Bulgarian Academy of Sciences
T2  - Bulgarian Chemical Communications
T1  - Hydrophilic gel containing coenzyme Q 10 -loaded liposomes: Preparation, characterization and stress stability tests
VL  - 51
IS  - 1
SP  - 117
EP  - 124
UR  - https://hdl.handle.net/21.15107/rcub_farfar_3283
ER  - 

@article{
author = "Dragičević, Nina and Krajišnik, Danina and Milić, Jela and Pecarski, D and Jugović, Z",
year = "2019",
abstract = "The aim of this study was to develop a semisolid formulation containing liposomes loaded with coenzyme Q10 (Q10). Q10-loaded liposome dispersion prepared from non-hydrogenated lecithin and characterized for particle size, polydispersity index (PDI), pH value and Q10-content was incorporated into carbomer gel, and a liposome gel was obtained. Liposome gel and liposome-free gel were analyzed for flow properties by continuous rheology measurements, pH values and Q10-content, 48 h after preparation and after a temperature stress test (1 cycle: 24 h at 4 o C, 24 h at 20±2 o C and 24 h at 40 o C), in order to predict their long-term stability. Liposomes were identified in liposome dispersion and liposome gel by freeze fracture electron microscopy (FFEM), while their particle size, PDI and zeta potential were determined by photon correlation spectroscopy (PCS). Q10-loaded liposomes were of small particle size (125 nm), homogeneous (PDI=0.2) and negatively charged, and their incorporation into the gel did not significantly change (p&0.05) their particle size and PDI. FFEM confirmed liposomes presence in the liposome gel. Liposome and liposome-free gel revealed non-Newtonian, shear-thinning plastic flow behavior. The temperature stress test revealed that temperature changes did not significantly influence (p&0.05) the pH value, while they significantly decreased (p&0.05) Q10-content in gels. Q10 was significantly more stable (p&0.05) in liposome gel than in liposome-free gel. Rheological parameters of liposome-free gel significantly changed, in contrast to the liposome gel. In conclusion, Q10-loaded liposome gel suitable for dermal use was developed, exhibiting high stability even after subjecting to the temperature stress test.",
publisher = "Bulgarian Academy of Sciences",
journal = "Bulgarian Chemical Communications",
title = "Hydrophilic gel containing coenzyme Q 10 -loaded liposomes: Preparation, characterization and stress stability tests",
volume = "51",
number = "1",
pages = "117-124",
url = "https://hdl.handle.net/21.15107/rcub_farfar_3283"
}

Dragičević, N., Krajišnik, D., Milić, J., Pecarski, D.,& Jugović, Z.. (2019). Hydrophilic gel containing coenzyme Q 10 -loaded liposomes: Preparation, characterization and stress stability tests. in Bulgarian Chemical Communications
Bulgarian Academy of Sciences., 51(1), 117-124.
https://hdl.handle.net/21.15107/rcub_farfar_3283

Dragičević N, Krajišnik D, Milić J, Pecarski D, Jugović Z. Hydrophilic gel containing coenzyme Q 10 -loaded liposomes: Preparation, characterization and stress stability tests. in Bulgarian Chemical Communications. 2019;51(1):117-124.
https://hdl.handle.net/21.15107/rcub_farfar_3283 .

Dragičević, Nina, Krajišnik, Danina, Milić, Jela, Pecarski, D, Jugović, Z, "Hydrophilic gel containing coenzyme Q 10 -loaded liposomes: Preparation, characterization and stress stability tests" in Bulgarian Chemical Communications, 51, no. 1 (2019):117-124,
https://hdl.handle.net/21.15107/rcub_farfar_3283 .

TY  - CONF
AU  - Martić, Radava
AU  - Krajišnik, Danina
AU  - Ušjak, Ljuboš
AU  - Petrović, Silvana
AU  - Savić, Snežana
AU  - Milić, Jela
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5247
AB  - INTRODUCTION
The SWOP (SWitch-Oil-Phase) emulsions are oil-in-water emulsions which are characterized by fast inversion into water-in-oil emulsions during application on the skin and consequent formation of a water-resistance layer over the skin [1]. Flavonoids quercetin (QUE) and dihydroquercetin (DHQ), as well as β-carotene (βC) are used in cosmetics as antioxidants. Additionally, these compounds show protective effects against ultraviolet radiation. Therefore, their incorporation into SWOP emulsion could result in a new waterproof sun protection product. The aim of this study was to prepare SWOP emulsion with 0.5% QUE (SQUE), 0.5% DHQ (SDHQ) and with combination of 0.5% DHQ and 0.2% βC (SDHQβC), and to evaluate DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging ability of incorporated antioxidants in comparison to the pure compounds.
MATERIALS AND METHODS
For this purpose, in vitro colorimetric DPPH assay was used [2, 3]. Results were expressed as the concentrations of antioxidants that scavenged 50% DPPH radicals, and analysed by one-way ANOVA, followed by Tukey’s post hoc test (α=0.05).
RESULTS
QUE and DHQ incorporated into SWOP emulsion exhibited strong anti-DPPH activity, without significant statistical difference compared to the pure compounds. The SC50 values of incorporated and pure QUE were 3.48±0.10 and 3.37±0.03 µg/mL, respectively. The SC50 values of DHQ incorporated in SDHQ and SDHQβC, and of pure DHQ were 5.36±0.27, 5.06±0.14 and 5.02±0.10 µg/mL, respectively. Neither incorporated nor pure βC showed anti-DPPH activity at tested concentrations (0.40-8.00 µg/mL). The SC50 values of tested SWOP emulsions, i.e. SQUE, SDHQ and SDHQβC were 0.70±0.02, 1.07±0.05, 1.01±0.03 mg/mL, respectively.
CONCLUSION
QUE and DHQ incorporated into SWOP emulsion retain their strong anti-DPPH activity, i.e. investigated SWOP emulsion is a suitable vehicle/base for the tested flavonoids. On the other hand, although known for its antioxidant activity, βC showed no anti-DPPH activity, which is in agreement with findings of some other authors [4]. Therefore, DPPH assay is not suitable for the testing of antioxidant activity of βC incorporated into SWOP emulsion.
REFERENCES
1.	Beuché M. et al. EP1917954 A1 (2008)
2.	Cuendet M. et al. Helv Chim Acta. 80, 1144-52 (1997)
3.	Casagrande R. et al. Int J Pharm. 328, 183–190 (2007)
4.	Müller L. et al. Food Chem. 129, 139-48 (2011)
PB  - Hungarian Society for Pharmaceutical Sciences
C3  - Acta Pharmaceutica Hungarica, 12th CESPT, Book of Abstracts
T1  - Investigation of DPPH radical scavenging ability of different antioxidants incorporated into fast inverted oil-in-water emulsion
VL  - 88
IS  - 043
SP  - 159
EP  - 160
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5247
ER  - 

@conference{
author = "Martić, Radava and Krajišnik, Danina and Ušjak, Ljuboš and Petrović, Silvana and Savić, Snežana and Milić, Jela",
year = "2018",
abstract = "INTRODUCTION
The SWOP (SWitch-Oil-Phase) emulsions are oil-in-water emulsions which are characterized by fast inversion into water-in-oil emulsions during application on the skin and consequent formation of a water-resistance layer over the skin [1]. Flavonoids quercetin (QUE) and dihydroquercetin (DHQ), as well as β-carotene (βC) are used in cosmetics as antioxidants. Additionally, these compounds show protective effects against ultraviolet radiation. Therefore, their incorporation into SWOP emulsion could result in a new waterproof sun protection product. The aim of this study was to prepare SWOP emulsion with 0.5% QUE (SQUE), 0.5% DHQ (SDHQ) and with combination of 0.5% DHQ and 0.2% βC (SDHQβC), and to evaluate DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging ability of incorporated antioxidants in comparison to the pure compounds.
MATERIALS AND METHODS
For this purpose, in vitro colorimetric DPPH assay was used [2, 3]. Results were expressed as the concentrations of antioxidants that scavenged 50% DPPH radicals, and analysed by one-way ANOVA, followed by Tukey’s post hoc test (α=0.05).
RESULTS
QUE and DHQ incorporated into SWOP emulsion exhibited strong anti-DPPH activity, without significant statistical difference compared to the pure compounds. The SC50 values of incorporated and pure QUE were 3.48±0.10 and 3.37±0.03 µg/mL, respectively. The SC50 values of DHQ incorporated in SDHQ and SDHQβC, and of pure DHQ were 5.36±0.27, 5.06±0.14 and 5.02±0.10 µg/mL, respectively. Neither incorporated nor pure βC showed anti-DPPH activity at tested concentrations (0.40-8.00 µg/mL). The SC50 values of tested SWOP emulsions, i.e. SQUE, SDHQ and SDHQβC were 0.70±0.02, 1.07±0.05, 1.01±0.03 mg/mL, respectively.
CONCLUSION
QUE and DHQ incorporated into SWOP emulsion retain their strong anti-DPPH activity, i.e. investigated SWOP emulsion is a suitable vehicle/base for the tested flavonoids. On the other hand, although known for its antioxidant activity, βC showed no anti-DPPH activity, which is in agreement with findings of some other authors [4]. Therefore, DPPH assay is not suitable for the testing of antioxidant activity of βC incorporated into SWOP emulsion.
REFERENCES
1.	Beuché M. et al. EP1917954 A1 (2008)
2.	Cuendet M. et al. Helv Chim Acta. 80, 1144-52 (1997)
3.	Casagrande R. et al. Int J Pharm. 328, 183–190 (2007)
4.	Müller L. et al. Food Chem. 129, 139-48 (2011)",
publisher = "Hungarian Society for Pharmaceutical Sciences",
journal = "Acta Pharmaceutica Hungarica, 12th CESPT, Book of Abstracts",
title = "Investigation of DPPH radical scavenging ability of different antioxidants incorporated into fast inverted oil-in-water emulsion",
volume = "88",
number = "043",
pages = "159-160",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5247"
}

Martić, R., Krajišnik, D., Ušjak, L., Petrović, S., Savić, S.,& Milić, J.. (2018). Investigation of DPPH radical scavenging ability of different antioxidants incorporated into fast inverted oil-in-water emulsion. in Acta Pharmaceutica Hungarica, 12th CESPT, Book of Abstracts
Hungarian Society for Pharmaceutical Sciences., 88(043), 159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5247

Martić R, Krajišnik D, Ušjak L, Petrović S, Savić S, Milić J. Investigation of DPPH radical scavenging ability of different antioxidants incorporated into fast inverted oil-in-water emulsion. in Acta Pharmaceutica Hungarica, 12th CESPT, Book of Abstracts. 2018;88(043):159-160.
https://hdl.handle.net/21.15107/rcub_farfar_5247 .

Martić, Radava, Krajišnik, Danina, Ušjak, Ljuboš, Petrović, Silvana, Savić, Snežana, Milić, Jela, "Investigation of DPPH radical scavenging ability of different antioxidants incorporated into fast inverted oil-in-water emulsion" in Acta Pharmaceutica Hungarica, 12th CESPT, Book of Abstracts, 88, no. 043 (2018):159-160,
https://hdl.handle.net/21.15107/rcub_farfar_5247 .

TY  - JOUR
AU  - Martić, Radava
AU  - Krajišnik, Danina
AU  - Milić, Jela
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3095
AB  - It is known that long-term exposure to ultraviolet (UV) radiation causes skin redness, solar erythema or burns, affects the structure of dermal connective tissue, increases the production of free radicals and the expression of matrix metalloproteinases, and can lead to the development of skin cancer. The World Health Organization recommends protective measures from the adverse effects of UV radiation, including the topical application of sunscreen products. One of the strategies for improving the quality and effectiveness of sunscreen products is introduction of new, more efficient and safer active molecules that absorb, reflect or disperse UV photons, as well as the introduction of substances that can prevent, neutralize or even repair damage caused by UV radiation. Significant potential for skin protection against harmful UV radiation is recognized in plant origin substances, which primarily exhibit an antioxidant effect, and additionally possess other photoprotective properties, which makes them interesting for further investigation. This paper presents an overview of the physicochemical properties of plant-based antioxidants, which are important for the formulation of the final cosmetic product and an overview of the potential effects of these substances in skin protection against UV radiation.
AB  - Poznato je da produženo izlaganje kože ultravioletnom (UV) zračenju dovodi do pojave crvenila, solarnog eritema ili opekotina, da utiče na strukturu vezivnog tkiva kože, proizvodnju slobodnih radikala, stimuliše proizvodnju matriks metaloproteinaza i da može dovesti do razvoja kancera kože. Svetska zdravstvena organizacija predlaže niz preventivnih mera za zaštitu kože od negativnih efekata UV zračenja, među kojima je i primena na kožu proizvoda za zaštitu od UV zračenja. Jedna od strategija za poboljšanje kvaliteta i efikasnosti proizvoda za zaštitu od UV zračenja je korišćenje novih, efikasnijih i bezbednijih aktivnih molekula koji apsorbuju, reflektuju ili rasipaju UV fotone, kao i uvođenje supstanci/materijala koji mogu da spreče, neutrališu i čak poprave oštećenja kože nastala delovanjem UV zračenja. Značajan potencijal za zaštitu kože od UV zračenja prepoznat je u supstancama/sastojcima biljnog porekla, koje primarno ispoljavaju antioksidantni efekat, a dodatno, poseduju i druge fotozaštitne osobine, što ih čini interesantnim za detaljnija istraživanja. U ovom radu je dat pregled fizičkohemijskih karakteristika antioksidanasa biljnog porekla, koje su značajne za formulaciju finalnog kozmetičkog proizvoda i potencijalnih efekata ovih sirovina/materijala u zaštiti kože od UV zračenja.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Antioxidants of plant origin in cosmetic products: Physicochemical properties and photoprotective potential
T1  - Antioksidansi biljnog porekla u kozmetičkim proizvodima - fizičkohemijske osobine i fotoprotektivni potencijal
VL  - 68
IS  - 1
SP  - 1
EP  - 33
DO  - 10.5937/arhFarm1801001M
ER  - 

@article{
author = "Martić, Radava and Krajišnik, Danina and Milić, Jela",
year = "2018",
abstract = "It is known that long-term exposure to ultraviolet (UV) radiation causes skin redness, solar erythema or burns, affects the structure of dermal connective tissue, increases the production of free radicals and the expression of matrix metalloproteinases, and can lead to the development of skin cancer. The World Health Organization recommends protective measures from the adverse effects of UV radiation, including the topical application of sunscreen products. One of the strategies for improving the quality and effectiveness of sunscreen products is introduction of new, more efficient and safer active molecules that absorb, reflect or disperse UV photons, as well as the introduction of substances that can prevent, neutralize or even repair damage caused by UV radiation. Significant potential for skin protection against harmful UV radiation is recognized in plant origin substances, which primarily exhibit an antioxidant effect, and additionally possess other photoprotective properties, which makes them interesting for further investigation. This paper presents an overview of the physicochemical properties of plant-based antioxidants, which are important for the formulation of the final cosmetic product and an overview of the potential effects of these substances in skin protection against UV radiation., Poznato je da produženo izlaganje kože ultravioletnom (UV) zračenju dovodi do pojave crvenila, solarnog eritema ili opekotina, da utiče na strukturu vezivnog tkiva kože, proizvodnju slobodnih radikala, stimuliše proizvodnju matriks metaloproteinaza i da može dovesti do razvoja kancera kože. Svetska zdravstvena organizacija predlaže niz preventivnih mera za zaštitu kože od negativnih efekata UV zračenja, među kojima je i primena na kožu proizvoda za zaštitu od UV zračenja. Jedna od strategija za poboljšanje kvaliteta i efikasnosti proizvoda za zaštitu od UV zračenja je korišćenje novih, efikasnijih i bezbednijih aktivnih molekula koji apsorbuju, reflektuju ili rasipaju UV fotone, kao i uvođenje supstanci/materijala koji mogu da spreče, neutrališu i čak poprave oštećenja kože nastala delovanjem UV zračenja. Značajan potencijal za zaštitu kože od UV zračenja prepoznat je u supstancama/sastojcima biljnog porekla, koje primarno ispoljavaju antioksidantni efekat, a dodatno, poseduju i druge fotozaštitne osobine, što ih čini interesantnim za detaljnija istraživanja. U ovom radu je dat pregled fizičkohemijskih karakteristika antioksidanasa biljnog porekla, koje su značajne za formulaciju finalnog kozmetičkog proizvoda i potencijalnih efekata ovih sirovina/materijala u zaštiti kože od UV zračenja.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Antioxidants of plant origin in cosmetic products: Physicochemical properties and photoprotective potential, Antioksidansi biljnog porekla u kozmetičkim proizvodima - fizičkohemijske osobine i fotoprotektivni potencijal",
volume = "68",
number = "1",
pages = "1-33",
doi = "10.5937/arhFarm1801001M"
}

Martić, R., Krajišnik, D.,& Milić, J.. (2018). Antioxidants of plant origin in cosmetic products: Physicochemical properties and photoprotective potential. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 68(1), 1-33.
https://doi.org/10.5937/arhFarm1801001M

Martić R, Krajišnik D, Milić J. Antioxidants of plant origin in cosmetic products: Physicochemical properties and photoprotective potential. in Arhiv za farmaciju. 2018;68(1):1-33.
doi:10.5937/arhFarm1801001M .

Martić, Radava, Krajišnik, Danina, Milić, Jela, "Antioxidants of plant origin in cosmetic products: Physicochemical properties and photoprotective potential" in Arhiv za farmaciju, 68, no. 1 (2018):1-33,
https://doi.org/10.5937/arhFarm1801001M . .

TY  - JOUR
AU  - Janićijević, Jelena
AU  - Milić, Jela
AU  - Čalija, Bojan
AU  - Micov, Ana
AU  - Stepanović-Petrović, Radica
AU  - Tomić, Maja
AU  - Daković, Aleksandra
AU  - Dobričić, Vladimir
AU  - Nedić-Vasiljević, Bojana
AU  - Krajišnik, Danina
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3050
AB  - Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.
PB  - Royal Soc Chemistry, Cambridge
T2  - Journal of Materials Chemistry B
T1  - Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite
VL  - 6
IS  - 36
SP  - 5812
EP  - 5822
DO  - 10.1039/c8tb01376d
ER  - 

@article{
author = "Janićijević, Jelena and Milić, Jela and Čalija, Bojan and Micov, Ana and Stepanović-Petrović, Radica and Tomić, Maja and Daković, Aleksandra and Dobričić, Vladimir and Nedić-Vasiljević, Bojana and Krajišnik, Danina",
year = "2018",
abstract = "Refined diatomite from the Kolubara coal basin (Serbia) was inorganically functionalized through a simple, one-pot, non-time-consuming procedure. Model drug ibuprofen was adsorbed on the functionalized diatomite under optimized conditions providing high drug Loading (similar to 201 mg g(-1)). Physicochemical characterization was performed on the starting and modified diatomite before and after ibuprofen adsorption. Dissolution testing was conducted on comprimates containing the drug adsorbed on the modified diatomite (composite) and those containing a physical mixture of the drug with the modified diatomite. The antihyperalgesic and the antiedematous activity of ibuprofen from both composites and physical mixtures were evaluated in vivo employing an inflammatory pain model in rats. Functionalization and subsequent drug adsorption had no significant effect on the diatomite ordered porous structure. Two forms of ibuprofen most likely coexisted in the adsorbed state - the acidic form and a salt/complex with aluminium. Both comprimate types showed extended ibuprofen release in vitro, but no significant influence on the duration of the ibuprofen effect was observed upon in vivo application of the composite or physical mixture. However, both the composite and the physical mixture were more effective than equivalent doses of ibuprofen in pain suppression in rats. This potentiation of the ibuprofen antihyperalgesic effect may result from the formation of the drug complex with the carrier and can be of clinical relevance.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Journal of Materials Chemistry B",
title = "Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite",
volume = "6",
number = "36",
pages = "5812-5822",
doi = "10.1039/c8tb01376d"
}

Janićijević, J., Milić, J., Čalija, B., Micov, A., Stepanović-Petrović, R., Tomić, M., Daković, A., Dobričić, V., Nedić-Vasiljević, B.,& Krajišnik, D.. (2018). Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite. in Journal of Materials Chemistry B
Royal Soc Chemistry, Cambridge., 6(36), 5812-5822.
https://doi.org/10.1039/c8tb01376d

Janićijević J, Milić J, Čalija B, Micov A, Stepanović-Petrović R, Tomić M, Daković A, Dobričić V, Nedić-Vasiljević B, Krajišnik D. Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite. in Journal of Materials Chemistry B. 2018;6(36):5812-5822.
doi:10.1039/c8tb01376d .

Janićijević, Jelena, Milić, Jela, Čalija, Bojan, Micov, Ana, Stepanović-Petrović, Radica, Tomić, Maja, Daković, Aleksandra, Dobričić, Vladimir, Nedić-Vasiljević, Bojana, Krajišnik, Danina, "Potentiation of the ibuprofen antihyperalgesic effect using inorganically functionalized diatomite" in Journal of Materials Chemistry B, 6, no. 36 (2018):5812-5822,
https://doi.org/10.1039/c8tb01376d . .

TY  - JOUR
AU  - Pantelić, Ivana
AU  - Savić, Snežana
AU  - Milić, Jela
AU  - Vuleta, Gordana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3097
AB  - Film-formers are cosmetic raw materials responsible for generating a film after their application. Recently, a certain expansion of these materials is noted, with numerous alleged functions and effects on skin or its appendages, making them a true example of multifunctional ingredients. CosIng database currently lists 965 ingredients with the recognized film-forming function. This paper offers a review of different types of film-formers as cosmetic raw materials, their properties and possible combinations in cosmetic products for skin, hair or nails. Although film-forming materials increasingly form part of contemporary cosmetic formulations, the paper mentions only the groups of cosmetic products that contain them in larger amounts, such as anti-age cosmetic products (lifting effect), sunscreens (water resistance and SPF/UVA-PF boosting), hair styling products and nail polishes. In line with the increase in their use, the Scientific Committee on Consumer Safety, operating within the European Commission, has announced recent development of scientific opinions on several cosmetic raw materials with film-forming properties.
AB  - Materijali/sastojci koji obrazuju film na mestu primene kozmetičkih proizvoda su poznati i pod nazivom film-formirajući materijali ili film-formeri. Poslednjih godina, primetno je povećanje broja ovih sirovina na tržištu, kojima se pripisuju različite uloge u kozmetičkim formulacijama, ali i kozmetički efekti na koži ili njenim adneksima, čineći ih dobrim primerom multifunkcionalnih sastojaka.CosIng baza podataka trenutno vodi čak 965 sastojaka sa ulogom 'film forming' sirovina. U radu je dat pregled film-formera različitog porekla, karakteristika i mogućnosti kombinovanja u kozmetičkim proizvodima za negu, zaštitu ili ulepšavanje kože, kose ili noktiju. Ove kozmetičke sirovine su sve češće deo savremenih kozmetičkih formulacija različite vrste i namene, ali su u radu obrađene one grupe kozmetičkih proizvoda koje ih sadrže u većoj koncentraciji, kao što su anti-age kozmetički proizvodi (lifting efekat), kozmetički proizvodi za zaštitu kože od sunca (vodootpornost i potenciranje SPF/UVA-PF faktora), za stilizovanje kose i dekorisanje noktiju. U skladu sa sve većom primenom, Naučni komitet za bezbednost korisnika pri Evropskoj komisiji najavio je skoro objavljivanje stručnih mišljenja o nekoliko kozmetičkih sastojaka iz ove grupe.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Film-forming materials in contemporary formulations of cosmetic products
T1  - Materijali koji obrazuju film u savremenim formulacijama kozmetičkih proizvoda
VL  - 68
IS  - 1
SP  - 46
EP  - 64
DO  - 10.5937/arhFarm1801046P
ER  - 

@article{
author = "Pantelić, Ivana and Savić, Snežana and Milić, Jela and Vuleta, Gordana",
year = "2018",
abstract = "Film-formers are cosmetic raw materials responsible for generating a film after their application. Recently, a certain expansion of these materials is noted, with numerous alleged functions and effects on skin or its appendages, making them a true example of multifunctional ingredients. CosIng database currently lists 965 ingredients with the recognized film-forming function. This paper offers a review of different types of film-formers as cosmetic raw materials, their properties and possible combinations in cosmetic products for skin, hair or nails. Although film-forming materials increasingly form part of contemporary cosmetic formulations, the paper mentions only the groups of cosmetic products that contain them in larger amounts, such as anti-age cosmetic products (lifting effect), sunscreens (water resistance and SPF/UVA-PF boosting), hair styling products and nail polishes. In line with the increase in their use, the Scientific Committee on Consumer Safety, operating within the European Commission, has announced recent development of scientific opinions on several cosmetic raw materials with film-forming properties., Materijali/sastojci koji obrazuju film na mestu primene kozmetičkih proizvoda su poznati i pod nazivom film-formirajući materijali ili film-formeri. Poslednjih godina, primetno je povećanje broja ovih sirovina na tržištu, kojima se pripisuju različite uloge u kozmetičkim formulacijama, ali i kozmetički efekti na koži ili njenim adneksima, čineći ih dobrim primerom multifunkcionalnih sastojaka.CosIng baza podataka trenutno vodi čak 965 sastojaka sa ulogom 'film forming' sirovina. U radu je dat pregled film-formera različitog porekla, karakteristika i mogućnosti kombinovanja u kozmetičkim proizvodima za negu, zaštitu ili ulepšavanje kože, kose ili noktiju. Ove kozmetičke sirovine su sve češće deo savremenih kozmetičkih formulacija različite vrste i namene, ali su u radu obrađene one grupe kozmetičkih proizvoda koje ih sadrže u većoj koncentraciji, kao što su anti-age kozmetički proizvodi (lifting efekat), kozmetički proizvodi za zaštitu kože od sunca (vodootpornost i potenciranje SPF/UVA-PF faktora), za stilizovanje kose i dekorisanje noktiju. U skladu sa sve većom primenom, Naučni komitet za bezbednost korisnika pri Evropskoj komisiji najavio je skoro objavljivanje stručnih mišljenja o nekoliko kozmetičkih sastojaka iz ove grupe.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Film-forming materials in contemporary formulations of cosmetic products, Materijali koji obrazuju film u savremenim formulacijama kozmetičkih proizvoda",
volume = "68",
number = "1",
pages = "46-64",
doi = "10.5937/arhFarm1801046P"
}

Pantelić, I., Savić, S., Milić, J.,& Vuleta, G.. (2018). Film-forming materials in contemporary formulations of cosmetic products. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 68(1), 46-64.
https://doi.org/10.5937/arhFarm1801046P

Pantelić I, Savić S, Milić J, Vuleta G. Film-forming materials in contemporary formulations of cosmetic products. in Arhiv za farmaciju. 2018;68(1):46-64.
doi:10.5937/arhFarm1801046P .

Pantelić, Ivana, Savić, Snežana, Milić, Jela, Vuleta, Gordana, "Film-forming materials in contemporary formulations of cosmetic products" in Arhiv za farmaciju, 68, no. 1 (2018):46-64,
https://doi.org/10.5937/arhFarm1801046P . .

TY  - JOUR
AU  - Marković, Marija
AU  - Daković, Aleksandra
AU  - Rottinghaus, George E.
AU  - Kragović, Milan
AU  - Petković, Andela
AU  - Krajišnik, Danina
AU  - Milić, Jela
AU  - Mercurio, Mariano
AU  - de Gennaro, Bruno
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2929
AB  - In this study, organozeolites were prepared by treatment of the natural zeolites (clinoptilolite and phillipsite) with cetylpyridinium chloride (CP) equivalent to 50 and 100% of their external cation exchange capacities (ECEC). Organoclinoptilolites (ZCPs) and organophillipsites (PCPs) were characterized by FTIR spectroscopy, thermal analysis, determination of the point of zero charge and zeta potential. Adsorption of zearalenone (ZEN) by ZCPs and PCPs at pH 3 and 7 was investigated. Results showed that adsorption of ZEN increases with increasing amounts of CP at the zeolitic surfaces for both ZCPs and PCPs but the adsorption mechanism was different. Adsorption of ZEN by ZCPs followed a linear type of isotherm at pH 3 and 7 while ZEN adsorption by PCPs showed non linear (Langmuir and Freundlich) type of isotherm at both pH values. Different interactions between the ZEN molecule (or ion) and ZCPs and PCPs occurred: partition (linear isotherms) and adsorption in addition to partition (non linear isotherms), respectively. For the highest level of organic phase at the zeolitic surfaces, the maximum adsorbed amount of ZEN was 5.73 mg/g for organoclinoptilolite and 6.86 mg/g for organophillipsite at pH 3. Slightly higher adsorption: 6.98 mg/g for organoclinoptilolite and 7.54 mg/g for organophillipsite was achieved at pH 7. The results confirmed that CP ions at both zeolitic surfaces are responsible for ZEN adsorption and that organophillipsites are as effective in ZEN adsorption as organoclinoptilolites.
PB  - Elsevier Science BV, Amsterdam
T2  - Colloids and Surfaces B: Biointerfaces
T1  - Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant
VL  - 151
SP  - 324
EP  - 332
DO  - 10.1016/j.colsurfb.2016.12.033
ER  - 

@article{
author = "Marković, Marija and Daković, Aleksandra and Rottinghaus, George E. and Kragović, Milan and Petković, Andela and Krajišnik, Danina and Milić, Jela and Mercurio, Mariano and de Gennaro, Bruno",
year = "2017",
abstract = "In this study, organozeolites were prepared by treatment of the natural zeolites (clinoptilolite and phillipsite) with cetylpyridinium chloride (CP) equivalent to 50 and 100% of their external cation exchange capacities (ECEC). Organoclinoptilolites (ZCPs) and organophillipsites (PCPs) were characterized by FTIR spectroscopy, thermal analysis, determination of the point of zero charge and zeta potential. Adsorption of zearalenone (ZEN) by ZCPs and PCPs at pH 3 and 7 was investigated. Results showed that adsorption of ZEN increases with increasing amounts of CP at the zeolitic surfaces for both ZCPs and PCPs but the adsorption mechanism was different. Adsorption of ZEN by ZCPs followed a linear type of isotherm at pH 3 and 7 while ZEN adsorption by PCPs showed non linear (Langmuir and Freundlich) type of isotherm at both pH values. Different interactions between the ZEN molecule (or ion) and ZCPs and PCPs occurred: partition (linear isotherms) and adsorption in addition to partition (non linear isotherms), respectively. For the highest level of organic phase at the zeolitic surfaces, the maximum adsorbed amount of ZEN was 5.73 mg/g for organoclinoptilolite and 6.86 mg/g for organophillipsite at pH 3. Slightly higher adsorption: 6.98 mg/g for organoclinoptilolite and 7.54 mg/g for organophillipsite was achieved at pH 7. The results confirmed that CP ions at both zeolitic surfaces are responsible for ZEN adsorption and that organophillipsites are as effective in ZEN adsorption as organoclinoptilolites.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces B: Biointerfaces",
title = "Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant",
volume = "151",
pages = "324-332",
doi = "10.1016/j.colsurfb.2016.12.033"
}

Marković, M., Daković, A., Rottinghaus, G. E., Kragović, M., Petković, A., Krajišnik, D., Milić, J., Mercurio, M.,& de Gennaro, B.. (2017). Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant. in Colloids and Surfaces B: Biointerfaces
Elsevier Science BV, Amsterdam., 151, 324-332.
https://doi.org/10.1016/j.colsurfb.2016.12.033

Marković M, Daković A, Rottinghaus GE, Kragović M, Petković A, Krajišnik D, Milić J, Mercurio M, de Gennaro B. Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant. in Colloids and Surfaces B: Biointerfaces. 2017;151:324-332.
doi:10.1016/j.colsurfb.2016.12.033 .

Marković, Marija, Daković, Aleksandra, Rottinghaus, George E., Kragović, Milan, Petković, Andela, Krajišnik, Danina, Milić, Jela, Mercurio, Mariano, de Gennaro, Bruno, "Adsorption of the mycotoxin zearalenone by clinoptilolite and phillipsite zeolites treated with cetylpyridinium surfactant" in Colloids and Surfaces B: Biointerfaces, 151 (2017):324-332,
https://doi.org/10.1016/j.colsurfb.2016.12.033 . .

TY  - JOUR
AU  - Marković, Marija
AU  - Daković, Aleksandra
AU  - Rottinghaus, George E.
AU  - Petković, Andela
AU  - Kragović, Milan
AU  - Krajišnik, Danina
AU  - Milić, Jela
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2827
AB  - Benzalkonium chloride - BC (the mixture of alkylbenzyldimethylammonium chlorides containing the alkyl groups having chain lengths of C8 to C18 and benzyl functional group) was used as a surfactant for production of organozeolites (BZs). The natural zeolite - clinoptilolite was modified with three different levels (2, 5 and 10 mmol/100 g) of BC. FTIR spectroscopy, thermal analysis, zeta potential measurements, determination of the point of zero charge and BET were used to determine the quantity of the surfactant at the zeolitic surface. The main aim was to investigate adsorption properties of BZs towards ochratoxin A (OCHRA) and zearalenone (ZEN) under in vitro conditions. Results showed that adsorption of OCHRA and ZEN by BZs increased with increasing amounts of BC at the zeolitic surface but the adsorption mechanism was different. Adsorption of OCHRA by BZs followed nonlinear isotherms at pH 3 and 7, and higher adsorption capacity was observed at pH 3. This indicates that adsorption was dependent on the form of OCHRA in solution and that the sites at the uncovered zeolitic surface together with the surfactants contributed to OCHRA adsorption. Adsorption of ZEN by BZs showed linear isotherms at pH 3 and 7 and similar amounts were adsorbed at both pH values. This suggests that adsorption is practically independent of the form of ZEN in solution and that organic cations at the zeolitic surface are the active sites relevant for ZEN adsorption.
PB  - Elsevier Science BV, Amsterdam
T2  - Colloids and Surfaces A: Physicochemical and Engineering Aspects
T1  - Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride
VL  - 529
SP  - 7
EP  - 17
DO  - 10.1016/j.colsurfa.2017.05.054
ER  - 

@article{
author = "Marković, Marija and Daković, Aleksandra and Rottinghaus, George E. and Petković, Andela and Kragović, Milan and Krajišnik, Danina and Milić, Jela",
year = "2017",
abstract = "Benzalkonium chloride - BC (the mixture of alkylbenzyldimethylammonium chlorides containing the alkyl groups having chain lengths of C8 to C18 and benzyl functional group) was used as a surfactant for production of organozeolites (BZs). The natural zeolite - clinoptilolite was modified with three different levels (2, 5 and 10 mmol/100 g) of BC. FTIR spectroscopy, thermal analysis, zeta potential measurements, determination of the point of zero charge and BET were used to determine the quantity of the surfactant at the zeolitic surface. The main aim was to investigate adsorption properties of BZs towards ochratoxin A (OCHRA) and zearalenone (ZEN) under in vitro conditions. Results showed that adsorption of OCHRA and ZEN by BZs increased with increasing amounts of BC at the zeolitic surface but the adsorption mechanism was different. Adsorption of OCHRA by BZs followed nonlinear isotherms at pH 3 and 7, and higher adsorption capacity was observed at pH 3. This indicates that adsorption was dependent on the form of OCHRA in solution and that the sites at the uncovered zeolitic surface together with the surfactants contributed to OCHRA adsorption. Adsorption of ZEN by BZs showed linear isotherms at pH 3 and 7 and similar amounts were adsorbed at both pH values. This suggests that adsorption is practically independent of the form of ZEN in solution and that organic cations at the zeolitic surface are the active sites relevant for ZEN adsorption.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",
title = "Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride",
volume = "529",
pages = "7-17",
doi = "10.1016/j.colsurfa.2017.05.054"
}

Marković, M., Daković, A., Rottinghaus, G. E., Petković, A., Kragović, M., Krajišnik, D.,& Milić, J.. (2017). Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride. in Colloids and Surfaces A: Physicochemical and Engineering Aspects
Elsevier Science BV, Amsterdam., 529, 7-17.
https://doi.org/10.1016/j.colsurfa.2017.05.054

Marković M, Daković A, Rottinghaus GE, Petković A, Kragović M, Krajišnik D, Milić J. Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride. in Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2017;529:7-17.
doi:10.1016/j.colsurfa.2017.05.054 .

Marković, Marija, Daković, Aleksandra, Rottinghaus, George E., Petković, Andela, Kragović, Milan, Krajišnik, Danina, Milić, Jela, "Ochratoxin A and zearalenone adsorption by the natural zeolite treated with benzalkonium chloride" in Colloids and Surfaces A: Physicochemical and Engineering Aspects, 529 (2017):7-17,
https://doi.org/10.1016/j.colsurfa.2017.05.054 . .

TY  - CHAP
AU  - Čalija, Bojan
AU  - Cekić, Nebojša
AU  - Milić, Jela
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2789
AB  - In the last 2 decades, numerous studies have been carried out to synthesize biodegradable and nontoxic micro- and nanoparticulate carriers for nonsteroidal anti-inflammatory drugs. The potential benefits of these carriers are reduction of dosing frequency and minimization of side effects due to prolonged/delayed drug release, increased selectivity for target tissues and possibility of direct administration to the site of action.This chapter discusses characteristics of alginate-based micro- and nanoparticles reinforced with chitosan and gives an overview of the techniques commonly used for preparation of these drug carriers. It is focused on the chitosans' functionality-related characteristics, such as molecular weight and viscosity, and their influence on feasibility of the alginate-chitosan particulate carriers for oral delivery of nonsteroidal anti-inflammatory drugs. Additionally, chitosan's structure, safety, and overall characteristics are discussed in detail for better understanding.
PB  - Elsevier Inc.
T2  - Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
T1  - Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced via Polyelectrolyte Complexation: Alginate-Chitosan Case Study
SP  - 133
EP  - 160
DO  - 10.1016/B978-0-12-804017-1.00005-4
ER  - 

@inbook{
author = "Čalija, Bojan and Cekić, Nebojša and Milić, Jela",
year = "2017",
abstract = "In the last 2 decades, numerous studies have been carried out to synthesize biodegradable and nontoxic micro- and nanoparticulate carriers for nonsteroidal anti-inflammatory drugs. The potential benefits of these carriers are reduction of dosing frequency and minimization of side effects due to prolonged/delayed drug release, increased selectivity for target tissues and possibility of direct administration to the site of action.This chapter discusses characteristics of alginate-based micro- and nanoparticles reinforced with chitosan and gives an overview of the techniques commonly used for preparation of these drug carriers. It is focused on the chitosans' functionality-related characteristics, such as molecular weight and viscosity, and their influence on feasibility of the alginate-chitosan particulate carriers for oral delivery of nonsteroidal anti-inflammatory drugs. Additionally, chitosan's structure, safety, and overall characteristics are discussed in detail for better understanding.",
publisher = "Elsevier Inc.",
journal = "Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a",
booktitle = "Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced via Polyelectrolyte Complexation: Alginate-Chitosan Case Study",
pages = "133-160",
doi = "10.1016/B978-0-12-804017-1.00005-4"
}

Čalija, B., Cekić, N.,& Milić, J.. (2017). Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced via Polyelectrolyte Complexation: Alginate-Chitosan Case Study. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
Elsevier Inc.., 133-160.
https://doi.org/10.1016/B978-0-12-804017-1.00005-4

Čalija B, Cekić N, Milić J. Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced via Polyelectrolyte Complexation: Alginate-Chitosan Case Study. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a. 2017;:133-160.
doi:10.1016/B978-0-12-804017-1.00005-4 .

Čalija, Bojan, Cekić, Nebojša, Milić, Jela, "Influence of Polycation Functional Properties on Polyanion Micro/Nanoparticles for NSAIDs Reinforced via Polyelectrolyte Complexation: Alginate-Chitosan Case Study" in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a (2017):133-160,
https://doi.org/10.1016/B978-0-12-804017-1.00005-4 . .

TY  - JOUR
AU  - Milić, Jela
AU  - Radojković, Branko
AU  - Jančić-Stojanović, Biljana
AU  - Drašković, Jasmina
AU  - Mirašević, Slavica
AU  - Čalija, Bojan
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2943
AB  - In this paper, a study exploring the stability of omeprazole in pediatric suspensions is presented. In order to determine the most suitable suspension, three different formulations were prepared and stored under refrigerated conditions and at room temperature for 30 days. Contents of omeprazole and preservatives were determined by liquid chromatographic method. Obtained results demonstrate that the vehicle consisting of: xanthan gum 0.3%, sodium bicarbonate 8%, Compound hydroxybenzoate solution APF 1% and purified water to 100% could have a significant potential in the development of a suitable omeprazole oral liquid for pediatric use. Namely, the content of omeprazole in the suspension prepared with this vehicle remained within acceptable range during the 30-day period, when stored refrigerated (2-8°C).
AB  - U ovom radu predstavljeno je ispitivanje stabilnosti omeprazola u suspenzijama za pedijatrijsku primenu, koje su izrađene iz komercijalno dostupnih kapsula omeprazola u uslovima apoteke. U cilju utvrđivanja najpogodnijeg vehikuluma za magistralnu izradu suspenzija omeprazola, pripremljene su tri formulacije, koje su potom 30 dana čuvane u frižideru i na sobnoj temperaturi. Sadržaj omeprazola i konzervansa u suspenzijama je određivan primenom tečne hromatografije. Dobijeni rezultati ukazuju da vehikulum koji se sastoji iz ksantan gume 0,3%, natrijum-bikarbonata 8%, rastvora parabena 1% (Compound hydroxybenzoate solution APF) i prečišćene vode do 100% ima značajan potencijal za razvoj pogodnog tečnog oblika omeprazola za peroralnu primenu u pedijatrijskoj populaciji. Naime, sadržaj omeprazola u suspenziji pripremljenoj primenom ovog vehikuluma je ostao u okviru prihvatljivih granica tokom perioda od 30 dana, kada je suspenzija čuvana u frižideru (2-8°C).
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules
T1  - Ispitivanje stabilnosti oralnih suspenzija omeprazola za pedijatrijsku primenu magistralno izrađenih iz omeprazol kapsula
VL  - 67
IS  - 1
SP  - 14
EP  - 25
DO  - 10.5937/arhfarm1701014M
ER  - 

@article{
author = "Milić, Jela and Radojković, Branko and Jančić-Stojanović, Biljana and Drašković, Jasmina and Mirašević, Slavica and Čalija, Bojan",
year = "2017",
abstract = "In this paper, a study exploring the stability of omeprazole in pediatric suspensions is presented. In order to determine the most suitable suspension, three different formulations were prepared and stored under refrigerated conditions and at room temperature for 30 days. Contents of omeprazole and preservatives were determined by liquid chromatographic method. Obtained results demonstrate that the vehicle consisting of: xanthan gum 0.3%, sodium bicarbonate 8%, Compound hydroxybenzoate solution APF 1% and purified water to 100% could have a significant potential in the development of a suitable omeprazole oral liquid for pediatric use. Namely, the content of omeprazole in the suspension prepared with this vehicle remained within acceptable range during the 30-day period, when stored refrigerated (2-8°C)., U ovom radu predstavljeno je ispitivanje stabilnosti omeprazola u suspenzijama za pedijatrijsku primenu, koje su izrađene iz komercijalno dostupnih kapsula omeprazola u uslovima apoteke. U cilju utvrđivanja najpogodnijeg vehikuluma za magistralnu izradu suspenzija omeprazola, pripremljene su tri formulacije, koje su potom 30 dana čuvane u frižideru i na sobnoj temperaturi. Sadržaj omeprazola i konzervansa u suspenzijama je određivan primenom tečne hromatografije. Dobijeni rezultati ukazuju da vehikulum koji se sastoji iz ksantan gume 0,3%, natrijum-bikarbonata 8%, rastvora parabena 1% (Compound hydroxybenzoate solution APF) i prečišćene vode do 100% ima značajan potencijal za razvoj pogodnog tečnog oblika omeprazola za peroralnu primenu u pedijatrijskoj populaciji. Naime, sadržaj omeprazola u suspenziji pripremljenoj primenom ovog vehikuluma je ostao u okviru prihvatljivih granica tokom perioda od 30 dana, kada je suspenzija čuvana u frižideru (2-8°C).",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules, Ispitivanje stabilnosti oralnih suspenzija omeprazola za pedijatrijsku primenu magistralno izrađenih iz omeprazol kapsula",
volume = "67",
number = "1",
pages = "14-25",
doi = "10.5937/arhfarm1701014M"
}

Milić, J., Radojković, B., Jančić-Stojanović, B., Drašković, J., Mirašević, S.,& Čalija, B.. (2017). Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 67(1), 14-25.
https://doi.org/10.5937/arhfarm1701014M

Milić J, Radojković B, Jančić-Stojanović B, Drašković J, Mirašević S, Čalija B. Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules. in Arhiv za farmaciju. 2017;67(1):14-25.
doi:10.5937/arhfarm1701014M .

Milić, Jela, Radojković, Branko, Jančić-Stojanović, Biljana, Drašković, Jasmina, Mirašević, Slavica, Čalija, Bojan, "Investigation of omeprazole stability in oral suspensions for pediatric use prepared extemporaneously from omeprazole capsules" in Arhiv za farmaciju, 67, no. 1 (2017):14-25,
https://doi.org/10.5937/arhfarm1701014M . .

TY  - JOUR
AU  - Kalusević, Ana
AU  - Lević, Steva
AU  - Čalija, Bojan
AU  - Pantić, Milena
AU  - Belović, Miona
AU  - Pavlović, Vladimir
AU  - Bugarski, Branko
AU  - Milić, Jela
AU  - Žilić, Slađana
AU  - Nedović, Viktor
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3427
AB  - Black soybean coat is insufficiently valorised food production waste rich in anthocyanins. The goal of the study was to examine physicochemical properties of spray dried extract of black soybean coat in regard to carrier materials: maltodextrin, gum Arabic, and skimmed milk powder. Maltodextrin and gum Arabic-based microparticles were spherical and non-porous while skimmed milk powder-based were irregularly shaped. Low water activity of microparticles (0.31-0.33), good powders characteristics, high solubility (80.3-94.3%) and encapsulation yields (63.7-77.0%) were determined. All microparticles exhibited significant antioxidant capacity (243-386 mu molTE/g), good colour stability after three months of storage and antimicrobial activity. High content of total anthocyanins, with cyanidin-3-glucoside as predominant, were achieved. In vitro release of anthocyanins from microparticles was sustained, particularly from gum Arabic-based. These findings suggest that proposed simple eco-friendly extraction and microencapsulation procedures could serve as valuable tools for valorisation and conversion of black soybean coat into highly functional and stable food colourant.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Microencapsulation
T1  - Microencapsulation of anthocyanin-rich black soybean coat extract by spray drying using maltodextrin, gum Arabic and skimmed milk powder
VL  - 34
IS  - 5
SP  - 475
EP  - 487
DO  - 10.1080/02652048.2017.1354939
ER  - 

@article{
author = "Kalusević, Ana and Lević, Steva and Čalija, Bojan and Pantić, Milena and Belović, Miona and Pavlović, Vladimir and Bugarski, Branko and Milić, Jela and Žilić, Slađana and Nedović, Viktor",
year = "2017",
abstract = "Black soybean coat is insufficiently valorised food production waste rich in anthocyanins. The goal of the study was to examine physicochemical properties of spray dried extract of black soybean coat in regard to carrier materials: maltodextrin, gum Arabic, and skimmed milk powder. Maltodextrin and gum Arabic-based microparticles were spherical and non-porous while skimmed milk powder-based were irregularly shaped. Low water activity of microparticles (0.31-0.33), good powders characteristics, high solubility (80.3-94.3%) and encapsulation yields (63.7-77.0%) were determined. All microparticles exhibited significant antioxidant capacity (243-386 mu molTE/g), good colour stability after three months of storage and antimicrobial activity. High content of total anthocyanins, with cyanidin-3-glucoside as predominant, were achieved. In vitro release of anthocyanins from microparticles was sustained, particularly from gum Arabic-based. These findings suggest that proposed simple eco-friendly extraction and microencapsulation procedures could serve as valuable tools for valorisation and conversion of black soybean coat into highly functional and stable food colourant.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Microencapsulation",
title = "Microencapsulation of anthocyanin-rich black soybean coat extract by spray drying using maltodextrin, gum Arabic and skimmed milk powder",
volume = "34",
number = "5",
pages = "475-487",
doi = "10.1080/02652048.2017.1354939"
}

Kalusević, A., Lević, S., Čalija, B., Pantić, M., Belović, M., Pavlović, V., Bugarski, B., Milić, J., Žilić, S.,& Nedović, V.. (2017). Microencapsulation of anthocyanin-rich black soybean coat extract by spray drying using maltodextrin, gum Arabic and skimmed milk powder. in Journal of Microencapsulation
Taylor & Francis Ltd, Abingdon., 34(5), 475-487.
https://doi.org/10.1080/02652048.2017.1354939

Kalusević A, Lević S, Čalija B, Pantić M, Belović M, Pavlović V, Bugarski B, Milić J, Žilić S, Nedović V. Microencapsulation of anthocyanin-rich black soybean coat extract by spray drying using maltodextrin, gum Arabic and skimmed milk powder. in Journal of Microencapsulation. 2017;34(5):475-487.
doi:10.1080/02652048.2017.1354939 .

Kalusević, Ana, Lević, Steva, Čalija, Bojan, Pantić, Milena, Belović, Miona, Pavlović, Vladimir, Bugarski, Branko, Milić, Jela, Žilić, Slađana, Nedović, Viktor, "Microencapsulation of anthocyanin-rich black soybean coat extract by spray drying using maltodextrin, gum Arabic and skimmed milk powder" in Journal of Microencapsulation, 34, no. 5 (2017):475-487,
https://doi.org/10.1080/02652048.2017.1354939 . .

TY  - CHAP
AU  - Milić, Jela
AU  - Čalija, Bojan
AU  - Đorđević, Sanela
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2893
AB  - Continuous efforts to improve performance of drugs via incorporation in particulate and soft colloidal carriers have introduced new functional categories of excipients. These excipients are used to protect drugs, modify their release, and increase their bioavailability and/or selectivity for target tissues with the aim to improve patient compliance, and therapeutic outcomes. Structural and physicochemical variability of these materials may affect their functionality in the final formulation. Therefore, it is of great importance to identify, evaluate, and control physical or chemical characteristics of excipients that are important for their intended use. These characteristics are known as functionality-related characteristics of excipients.This chapter gives an overview of characteristics and variability of the three distinct groups of excipients commonly used for preparation of particulate and soft colloidal carriers: biodegradable polymeric materials, silica-based materials, and natural surfactants. Special attention is paid to functionality, functionality-related characteristics, and functionalization of these materials in relation to their use for preparation of micro/nanosized drug carriers.
PB  - Elsevier Inc.
T2  - Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
T1  - Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers
SP  - 95
EP  - 132
DO  - 10.1016/B978-0-12-804017-1.00004-2
ER  - 

@inbook{
author = "Milić, Jela and Čalija, Bojan and Đorđević, Sanela",
year = "2017",
abstract = "Continuous efforts to improve performance of drugs via incorporation in particulate and soft colloidal carriers have introduced new functional categories of excipients. These excipients are used to protect drugs, modify their release, and increase their bioavailability and/or selectivity for target tissues with the aim to improve patient compliance, and therapeutic outcomes. Structural and physicochemical variability of these materials may affect their functionality in the final formulation. Therefore, it is of great importance to identify, evaluate, and control physical or chemical characteristics of excipients that are important for their intended use. These characteristics are known as functionality-related characteristics of excipients.This chapter gives an overview of characteristics and variability of the three distinct groups of excipients commonly used for preparation of particulate and soft colloidal carriers: biodegradable polymeric materials, silica-based materials, and natural surfactants. Special attention is paid to functionality, functionality-related characteristics, and functionalization of these materials in relation to their use for preparation of micro/nanosized drug carriers.",
publisher = "Elsevier Inc.",
journal = "Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a",
booktitle = "Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers",
pages = "95-132",
doi = "10.1016/B978-0-12-804017-1.00004-2"
}

Milić, J., Čalija, B.,& Đorđević, S.. (2017). Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
Elsevier Inc.., 95-132.
https://doi.org/10.1016/B978-0-12-804017-1.00004-2

Milić J, Čalija B, Đorđević S. Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a. 2017;:95-132.
doi:10.1016/B978-0-12-804017-1.00004-2 .

Milić, Jela, Čalija, Bojan, Đorđević, Sanela, "Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers" in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a (2017):95-132,
https://doi.org/10.1016/B978-0-12-804017-1.00004-2 . .

TY  - CHAP
AU  - Krajišnik, Danina
AU  - Daković, Aleksandra
AU  - Janićijević, Jelena
AU  - Milić, Jela
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2819
AB  - In the last two decades several representatives of natural silica-based materials (clays, zeolites, and diatomites) have emerged in biomedical applications due to their favorable physicochemical and functionality-related characteristics along with good biocompatibility. The possibility of their use in drug delivery as carriers for NSAIDs, as one of the most widely prescribed drugs, is particularly interesting since it would overcome some of the therapy-related side effects and improve patience compliance.This chapter gives an overview of natural silica-based materials' characteristics relevant for their pharmaceutical use, along with various examples of their structure modification in order to obtain materials with improved functional properties as potential drug carriers. A review on application of these materials in drug delivery of NSAIDs is presented including evaluation of techniques used for drug silica based carrier characterization in addition to investigation of their biopharmaceutical performances.
PB  - Elsevier Inc.
T2  - Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
T1  - Natural and Modified Silica-Based Materials as Carriers for NSAIDs
SP  - 219
EP  - 258
DO  - 10.1016/B978-0-12-804017-1.00008-X
ER  - 

@inbook{
author = "Krajišnik, Danina and Daković, Aleksandra and Janićijević, Jelena and Milić, Jela",
year = "2017",
abstract = "In the last two decades several representatives of natural silica-based materials (clays, zeolites, and diatomites) have emerged in biomedical applications due to their favorable physicochemical and functionality-related characteristics along with good biocompatibility. The possibility of their use in drug delivery as carriers for NSAIDs, as one of the most widely prescribed drugs, is particularly interesting since it would overcome some of the therapy-related side effects and improve patience compliance.This chapter gives an overview of natural silica-based materials' characteristics relevant for their pharmaceutical use, along with various examples of their structure modification in order to obtain materials with improved functional properties as potential drug carriers. A review on application of these materials in drug delivery of NSAIDs is presented including evaluation of techniques used for drug silica based carrier characterization in addition to investigation of their biopharmaceutical performances.",
publisher = "Elsevier Inc.",
journal = "Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a",
booktitle = "Natural and Modified Silica-Based Materials as Carriers for NSAIDs",
pages = "219-258",
doi = "10.1016/B978-0-12-804017-1.00008-X"
}

Krajišnik, D., Daković, A., Janićijević, J.,& Milić, J.. (2017). Natural and Modified Silica-Based Materials as Carriers for NSAIDs. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a
Elsevier Inc.., 219-258.
https://doi.org/10.1016/B978-0-12-804017-1.00008-X

Krajišnik D, Daković A, Janićijević J, Milić J. Natural and Modified Silica-Based Materials as Carriers for NSAIDs. in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a. 2017;:219-258.
doi:10.1016/B978-0-12-804017-1.00008-X .

Krajišnik, Danina, Daković, Aleksandra, Janićijević, Jelena, Milić, Jela, "Natural and Modified Silica-Based Materials as Carriers for NSAIDs" in Microsized and Nanosized Carriers for Nonsteroidal Anti-Inflammatory Drugs: Formulation Challenges a (2017):219-258,
https://doi.org/10.1016/B978-0-12-804017-1.00008-X . .

TY  - JOUR
AU  - Đuriš, Jelena
AU  - Čalija, Bojan
AU  - Vidović, Bojana
AU  - Dobričić, Vladimir
AU  - Milić, Jela
AU  - Ibrić, Svetlana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3010
AB  - Previous reports revealed several concerns related to the quality of marketed folic acid dietary supplements with potential influence on their efficacy, such as underdosages of the folic acid content, complexity of composition and the failure to meet the disintegration and/or dissolution requirements. This study was aimed to compare various marketed folic acid supplements, formulated as single- or multicomponent products, by testing their weight variation, friability, hardness, disintegration and dissolution properties according to the compendial requirements; accompanied with the investigation of influence of composition on the dosage form properties. The obtained results revealed significant differences in mechanical and dissolution properties between the tested supplements, especially between the single- and multicomponent products, where most of the multicomponent products failed to meet the compendial requirements for either dissolution or disintegration. These findings indicate the need for harmonized and strict regulatory requirements for the quality of multicomponent dietary supplements.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Journal of Food Composition and Analysis
T1  - Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements
VL  - 60
SP  - 17
EP  - 24
DO  - 10.1016/j.jfca.2017.03.005
ER  - 

@article{
author = "Đuriš, Jelena and Čalija, Bojan and Vidović, Bojana and Dobričić, Vladimir and Milić, Jela and Ibrić, Svetlana",
year = "2017",
abstract = "Previous reports revealed several concerns related to the quality of marketed folic acid dietary supplements with potential influence on their efficacy, such as underdosages of the folic acid content, complexity of composition and the failure to meet the disintegration and/or dissolution requirements. This study was aimed to compare various marketed folic acid supplements, formulated as single- or multicomponent products, by testing their weight variation, friability, hardness, disintegration and dissolution properties according to the compendial requirements; accompanied with the investigation of influence of composition on the dosage form properties. The obtained results revealed significant differences in mechanical and dissolution properties between the tested supplements, especially between the single- and multicomponent products, where most of the multicomponent products failed to meet the compendial requirements for either dissolution or disintegration. These findings indicate the need for harmonized and strict regulatory requirements for the quality of multicomponent dietary supplements.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Journal of Food Composition and Analysis",
title = "Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements",
volume = "60",
pages = "17-24",
doi = "10.1016/j.jfca.2017.03.005"
}

Đuriš, J., Čalija, B., Vidović, B., Dobričić, V., Milić, J.,& Ibrić, S.. (2017). Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements. in Journal of Food Composition and Analysis
Academic Press Inc Elsevier Science, San Diego., 60, 17-24.
https://doi.org/10.1016/j.jfca.2017.03.005

Đuriš J, Čalija B, Vidović B, Dobričić V, Milić J, Ibrić S. Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements. in Journal of Food Composition and Analysis. 2017;60:17-24.
doi:10.1016/j.jfca.2017.03.005 .

Đuriš, Jelena, Čalija, Bojan, Vidović, Bojana, Dobričić, Vladimir, Milić, Jela, Ibrić, Svetlana, "Comparative analysis of mechanical and dissolution properties of single- and multicomponent folic acid supplements" in Journal of Food Composition and Analysis, 60 (2017):17-24,
https://doi.org/10.1016/j.jfca.2017.03.005 . .

TY  - JOUR
AU  - Kalusević, Ana
AU  - Lević, Steva
AU  - Čalija, Bojan
AU  - Milić, Jela
AU  - Pavlović, Vladimir
AU  - Bugarski, Branko
AU  - Nedović, Viktor
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2876
AB  - The goal of this study was to investigate the characteristics of grape skin extract (GSE) spray dried with different carriers: maltodextrin (MD), gum Arabic (GA) and skim milk powder (SMP). The grape skin extract was obtained from winery by-product of red grape variety Prokupac (Vitis vinifera L.). The morphology of the powders, their thermal, chemical and physical properties (water activity, bulk and tapped densities, solubility), as well as release studies in different pH conditions were analyzed. Total anthocyanin content and total phenolic content were determined by spectrophotometric methods. MD and GA-based microparticles were non-porous and spherical, while SMP-based ones were irregularly shaped. The process of spray drying Prokupac GSE using these three carriers produced powders with low water activity (0.24-0.28), good powder characteristics, high yields, and solubility higher than 90%. The obtained dissolution/release profiles indicated prolonged release of anthocyanins and phenolic compounds in different mediums, especially from GSE/GA microparticles. These results have shown that grape skin as the main by-product of wine production could be used as a source of natural colorants and bioactive compounds, and microencapsulation as a promising technique for the protection of these compounds, their stabilization in longer periods and prolonged release.
PB  - Springer India, New Delhi
T2  - Journal of Food Science and Technology-Mysore
T1  - Effects of different carrier materials on physicochemical properties of microencapsulated grape skin extract
VL  - 54
IS  - 11
SP  - 3411
EP  - 3420
DO  - 10.1007/s13197-017-2790-6
ER  - 

@article{
author = "Kalusević, Ana and Lević, Steva and Čalija, Bojan and Milić, Jela and Pavlović, Vladimir and Bugarski, Branko and Nedović, Viktor",
year = "2017",
abstract = "The goal of this study was to investigate the characteristics of grape skin extract (GSE) spray dried with different carriers: maltodextrin (MD), gum Arabic (GA) and skim milk powder (SMP). The grape skin extract was obtained from winery by-product of red grape variety Prokupac (Vitis vinifera L.). The morphology of the powders, their thermal, chemical and physical properties (water activity, bulk and tapped densities, solubility), as well as release studies in different pH conditions were analyzed. Total anthocyanin content and total phenolic content were determined by spectrophotometric methods. MD and GA-based microparticles were non-porous and spherical, while SMP-based ones were irregularly shaped. The process of spray drying Prokupac GSE using these three carriers produced powders with low water activity (0.24-0.28), good powder characteristics, high yields, and solubility higher than 90%. The obtained dissolution/release profiles indicated prolonged release of anthocyanins and phenolic compounds in different mediums, especially from GSE/GA microparticles. These results have shown that grape skin as the main by-product of wine production could be used as a source of natural colorants and bioactive compounds, and microencapsulation as a promising technique for the protection of these compounds, their stabilization in longer periods and prolonged release.",
publisher = "Springer India, New Delhi",
journal = "Journal of Food Science and Technology-Mysore",
title = "Effects of different carrier materials on physicochemical properties of microencapsulated grape skin extract",
volume = "54",
number = "11",
pages = "3411-3420",
doi = "10.1007/s13197-017-2790-6"
}

Kalusević, A., Lević, S., Čalija, B., Milić, J., Pavlović, V., Bugarski, B.,& Nedović, V.. (2017). Effects of different carrier materials on physicochemical properties of microencapsulated grape skin extract. in Journal of Food Science and Technology-Mysore
Springer India, New Delhi., 54(11), 3411-3420.
https://doi.org/10.1007/s13197-017-2790-6

Kalusević A, Lević S, Čalija B, Milić J, Pavlović V, Bugarski B, Nedović V. Effects of different carrier materials on physicochemical properties of microencapsulated grape skin extract. in Journal of Food Science and Technology-Mysore. 2017;54(11):3411-3420.
doi:10.1007/s13197-017-2790-6 .

Kalusević, Ana, Lević, Steva, Čalija, Bojan, Milić, Jela, Pavlović, Vladimir, Bugarski, Branko, Nedović, Viktor, "Effects of different carrier materials on physicochemical properties of microencapsulated grape skin extract" in Journal of Food Science and Technology-Mysore, 54, no. 11 (2017):3411-3420,
https://doi.org/10.1007/s13197-017-2790-6 . .