TY  - CONF
AU  - Popović-Nikolić, Marija
AU  - Nikolić, Katarina
AU  - Aleksić, Mara
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5044
AB  - he redox properties of two quinoxaline derivatives, brimonidine and varenicline,
previously studied electrochemically, were evaluated by performing a computational study. On
the basis of some useful quantum chemical parameters the differences and similarities between
their redox features were explained. The obtained results support the experimental findings that
the redox processes of both compounds are under strong influence of the solution pH, whereas
the reduction of brimonidine occurs easier than the reduction of varenicline, at corresponding pH
values.
PB  - Institute for Information Technologies, University of Kragujevac, Serbia
C3  - 2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023, BOOK OF PROCEEDINGS
T1  - DFT approach of the redox properties of brimonidine and varenicline
SP  - 423
EP  - 426
DO  - 10.46793/ICCBI23.423PN
ER  - 

@conference{
author = "Popović-Nikolić, Marija and Nikolić, Katarina and Aleksić, Mara",
year = "2023",
abstract = "he redox properties of two quinoxaline derivatives, brimonidine and varenicline,
previously studied electrochemically, were evaluated by performing a computational study. On
the basis of some useful quantum chemical parameters the differences and similarities between
their redox features were explained. The obtained results support the experimental findings that
the redox processes of both compounds are under strong influence of the solution pH, whereas
the reduction of brimonidine occurs easier than the reduction of varenicline, at corresponding pH
values.",
publisher = "Institute for Information Technologies, University of Kragujevac, Serbia",
journal = "2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023, BOOK OF PROCEEDINGS",
title = "DFT approach of the redox properties of brimonidine and varenicline",
pages = "423-426",
doi = "10.46793/ICCBI23.423PN"
}

Popović-Nikolić, M., Nikolić, K.,& Aleksić, M.. (2023). DFT approach of the redox properties of brimonidine and varenicline. in 2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023, BOOK OF PROCEEDINGS
Institute for Information Technologies, University of Kragujevac, Serbia., 423-426.
https://doi.org/10.46793/ICCBI23.423PN

Popović-Nikolić M, Nikolić K, Aleksić M. DFT approach of the redox properties of brimonidine and varenicline. in 2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023, BOOK OF PROCEEDINGS. 2023;:423-426.
doi:10.46793/ICCBI23.423PN .

Popović-Nikolić, Marija, Nikolić, Katarina, Aleksić, Mara, "DFT approach of the redox properties of brimonidine and varenicline" in 2nd International Conference on Chemo and Bioinformatics ICCBIKG 2023, BOOK OF PROCEEDINGS (2023):423-426,
https://doi.org/10.46793/ICCBI23.423PN . .

TY  - JOUR
AU  - Jovanović, Milan
AU  - Nikolić, Katarina
AU  - Čarapić, Marija
AU  - Aleksić, Mara
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4931
AB  - A comprehensive investigation of tyrosine kinase inhibitor erlotinib (ERL) electrochemical behavior and interaction with DNA was performed with the aim to clarify its redox mechanism and to determine the mode of binding. Irreversible oxidation and reduction processes of ERL on glassy carbon electrode were investigated using three voltammetric techniques CV, DPV, SWV in pH range between 2.0 and 9.0. Oxidation was established as an adsorption-controlled process, while the reduction manifested diffusion-adsorption mixed controlled process in acidic medium and adsorption became predominant in the neutral solutions. According to the determined number of transferred electrons and protons, oxidation and reduction mechanism of ERL are proposed. To follow the interaction between ERL and DNA, the multilayer ct-DNA electrochemical biosensor was incubated in ERL solutions concentrations ranged from 2 × 10–7 M to 5 × 10–5 M (pH 4.6) for 30 min. SWV measurements have shown the decrease in deoxyadenosine peak current as a consequence of ERL increased concentration and binding to ct-DNA. The calculated value of binding constant was K = 8.25 × 104 M−1. Molecular docking showed that ERL forms hydrophobic interactions when docked into minor groove, as well as when intercalated, and molecular dynamics analysis predicted the stability of obtained complexes. These results together with voltammetric studies imply that the intercalation could be more dominant way ERL binding to DNA compared to minor groove binding.
PB  - Elsevier B.V.
T2  - Journal of Pharmaceutical and Biomedical Analysis
T1  - Electrochemical and theoretical study on interaction between erlotinib and DNA
VL  - 234
DO  - 10.1016/j.jpba.2023.115560
ER  - 

@article{
author = "Jovanović, Milan and Nikolić, Katarina and Čarapić, Marija and Aleksić, Mara",
year = "2023",
abstract = "A comprehensive investigation of tyrosine kinase inhibitor erlotinib (ERL) electrochemical behavior and interaction with DNA was performed with the aim to clarify its redox mechanism and to determine the mode of binding. Irreversible oxidation and reduction processes of ERL on glassy carbon electrode were investigated using three voltammetric techniques CV, DPV, SWV in pH range between 2.0 and 9.0. Oxidation was established as an adsorption-controlled process, while the reduction manifested diffusion-adsorption mixed controlled process in acidic medium and adsorption became predominant in the neutral solutions. According to the determined number of transferred electrons and protons, oxidation and reduction mechanism of ERL are proposed. To follow the interaction between ERL and DNA, the multilayer ct-DNA electrochemical biosensor was incubated in ERL solutions concentrations ranged from 2 × 10–7 M to 5 × 10–5 M (pH 4.6) for 30 min. SWV measurements have shown the decrease in deoxyadenosine peak current as a consequence of ERL increased concentration and binding to ct-DNA. The calculated value of binding constant was K = 8.25 × 104 M−1. Molecular docking showed that ERL forms hydrophobic interactions when docked into minor groove, as well as when intercalated, and molecular dynamics analysis predicted the stability of obtained complexes. These results together with voltammetric studies imply that the intercalation could be more dominant way ERL binding to DNA compared to minor groove binding.",
publisher = "Elsevier B.V.",
journal = "Journal of Pharmaceutical and Biomedical Analysis",
title = "Electrochemical and theoretical study on interaction between erlotinib and DNA",
volume = "234",
doi = "10.1016/j.jpba.2023.115560"
}

Jovanović, M., Nikolić, K., Čarapić, M.,& Aleksić, M.. (2023). Electrochemical and theoretical study on interaction between erlotinib and DNA. in Journal of Pharmaceutical and Biomedical Analysis
Elsevier B.V.., 234.
https://doi.org/10.1016/j.jpba.2023.115560

Jovanović M, Nikolić K, Čarapić M, Aleksić M. Electrochemical and theoretical study on interaction between erlotinib and DNA. in Journal of Pharmaceutical and Biomedical Analysis. 2023;234.
doi:10.1016/j.jpba.2023.115560 .

Jovanović, Milan, Nikolić, Katarina, Čarapić, Marija, Aleksić, Mara, "Electrochemical and theoretical study on interaction between erlotinib and DNA" in Journal of Pharmaceutical and Biomedical Analysis, 234 (2023),
https://doi.org/10.1016/j.jpba.2023.115560 . .

TY  - JOUR
AU  - Selaković, Milan
AU  - Aleksić, Mara
AU  - Kotur-Stevuljević, Jelena
AU  - Rupar, Jelena
AU  - Ivković, Branka
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4550
AB  - Ivermectin (IVM) is a drug from the group of anthelmintics used in veterinary and human medicine. Recently, interest in IVM has increased as it has been used for the treatment of some malignant diseases, as well as viral infections caused by the Zika virus, HIV-1 and SARS-CoV-2. The electrochemical behaviour of IVM was investigated using cyclic (CV), differential pulse (DPV) and square wave voltammetry (SWV) at glassy carbon electrode (GCE). IVM showed independent oxidation and reduction processes. The effect of pH and scan rate indicated the irreversibility of all processes and confirmed the diffusion character of oxidation and reduction as an adsorption-controlled process. Mechanisms for IVM oxidation at the tetrahydrofuran ring and reduction of the 1,4-diene structure in the IVM molecule are proposed. The redox behaviour of IVM in a biological matrix (human serum pool) showed a pronounced antioxidant potential similar to that of Trolox during short incubation, whereas a prolonged stay among biomolecules and in the presence of an exogenous pro-oxidant (tert-butyl hydroperoxide, TBH) resulted in a loss of its antioxidant effect. The antioxidant potential of IVM was confirmed by voltametric methodology which is proposed for the first time.
PB  - MDPI
T2  - Molecules
T1  - Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium
VL  - 28
IS  - 5
DO  - 10.3390/molecules28052113
ER  - 

@article{
author = "Selaković, Milan and Aleksić, Mara and Kotur-Stevuljević, Jelena and Rupar, Jelena and Ivković, Branka",
year = "2023",
abstract = "Ivermectin (IVM) is a drug from the group of anthelmintics used in veterinary and human medicine. Recently, interest in IVM has increased as it has been used for the treatment of some malignant diseases, as well as viral infections caused by the Zika virus, HIV-1 and SARS-CoV-2. The electrochemical behaviour of IVM was investigated using cyclic (CV), differential pulse (DPV) and square wave voltammetry (SWV) at glassy carbon electrode (GCE). IVM showed independent oxidation and reduction processes. The effect of pH and scan rate indicated the irreversibility of all processes and confirmed the diffusion character of oxidation and reduction as an adsorption-controlled process. Mechanisms for IVM oxidation at the tetrahydrofuran ring and reduction of the 1,4-diene structure in the IVM molecule are proposed. The redox behaviour of IVM in a biological matrix (human serum pool) showed a pronounced antioxidant potential similar to that of Trolox during short incubation, whereas a prolonged stay among biomolecules and in the presence of an exogenous pro-oxidant (tert-butyl hydroperoxide, TBH) resulted in a loss of its antioxidant effect. The antioxidant potential of IVM was confirmed by voltametric methodology which is proposed for the first time.",
publisher = "MDPI",
journal = "Molecules",
title = "Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium",
volume = "28",
number = "5",
doi = "10.3390/molecules28052113"
}

Selaković, M., Aleksić, M., Kotur-Stevuljević, J., Rupar, J.,& Ivković, B.. (2023). Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium. in Molecules
MDPI., 28(5).
https://doi.org/10.3390/molecules28052113

Selaković M, Aleksić M, Kotur-Stevuljević J, Rupar J, Ivković B. Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium. in Molecules. 2023;28(5).
doi:10.3390/molecules28052113 .

Selaković, Milan, Aleksić, Mara, Kotur-Stevuljević, Jelena, Rupar, Jelena, Ivković, Branka, "Electrochemical Characterisation and Confirmation of Antioxidative Properties of Ivermectin in Biological Medium" in Molecules, 28, no. 5 (2023),
https://doi.org/10.3390/molecules28052113 . .

TY  - JOUR
AU  - Rupar, Jelena
AU  - Dobričić, Vladimir
AU  - Brborić, Jasmina
AU  - Čudina, Olivera
AU  - Aleksić, Mara
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4323
AB  - Electrochemical oxidation of newly synthesized acridine derivatives (ADs): PG, PA, EG and EA was studied using square wave voltammetry at a glassy carbon electrode. Oxidation occurs as an irreversible process for all ADs. The ADs interaction with DNA was investigated using multi-layer DNA electrochemical biosensor. The shift of dA peak in positive direction indicated that the type of interaction is most likely an intercalation. PG showed the widest range of concentration capable to interact with DNA (1 × 10−7 M − 2.5 × 10−4 M). Analysing [Formula presented] vs logcAD plots, the binding constants were determined. For the lowest PG concentrations, obtained K value close to 106 M−1 refers to strong binding. The values of K for PA may be classified as medium strength, while EG and EA showed low K values. Our results unequivocally showed that the characteristics of association complexes may vary depending on the concentration of the interacting substance. The negative ΔG value for all ADs, (- 21 to - 34 kJ mol−1), confirms the process spontaneity. The best result, indicating the most stable formed complex with DNA adsorbed at the electrode surface, showed PG when present in low concentration, order of 10−7 M. The intercalation of ADs into DNA was supported by molecular docking analysis.
PB  - Elsevier B.V.
T2  - Bioelectrochemistry
T1  - Square wave voltammetric study of interaction between 9-acridinyl amino acid derivatives and DNA
VL  - 149
DO  - 10.1016/j.bioelechem.2022.108323
ER  - 

@article{
author = "Rupar, Jelena and Dobričić, Vladimir and Brborić, Jasmina and Čudina, Olivera and Aleksić, Mara",
year = "2023",
abstract = "Electrochemical oxidation of newly synthesized acridine derivatives (ADs): PG, PA, EG and EA was studied using square wave voltammetry at a glassy carbon electrode. Oxidation occurs as an irreversible process for all ADs. The ADs interaction with DNA was investigated using multi-layer DNA electrochemical biosensor. The shift of dA peak in positive direction indicated that the type of interaction is most likely an intercalation. PG showed the widest range of concentration capable to interact with DNA (1 × 10−7 M − 2.5 × 10−4 M). Analysing [Formula presented] vs logcAD plots, the binding constants were determined. For the lowest PG concentrations, obtained K value close to 106 M−1 refers to strong binding. The values of K for PA may be classified as medium strength, while EG and EA showed low K values. Our results unequivocally showed that the characteristics of association complexes may vary depending on the concentration of the interacting substance. The negative ΔG value for all ADs, (- 21 to - 34 kJ mol−1), confirms the process spontaneity. The best result, indicating the most stable formed complex with DNA adsorbed at the electrode surface, showed PG when present in low concentration, order of 10−7 M. The intercalation of ADs into DNA was supported by molecular docking analysis.",
publisher = "Elsevier B.V.",
journal = "Bioelectrochemistry",
title = "Square wave voltammetric study of interaction between 9-acridinyl amino acid derivatives and DNA",
volume = "149",
doi = "10.1016/j.bioelechem.2022.108323"
}

Rupar, J., Dobričić, V., Brborić, J., Čudina, O.,& Aleksić, M.. (2023). Square wave voltammetric study of interaction between 9-acridinyl amino acid derivatives and DNA. in Bioelectrochemistry
Elsevier B.V.., 149.
https://doi.org/10.1016/j.bioelechem.2022.108323

Rupar J, Dobričić V, Brborić J, Čudina O, Aleksić M. Square wave voltammetric study of interaction between 9-acridinyl amino acid derivatives and DNA. in Bioelectrochemistry. 2023;149.
doi:10.1016/j.bioelechem.2022.108323 .

Rupar, Jelena, Dobričić, Vladimir, Brborić, Jasmina, Čudina, Olivera, Aleksić, Mara, "Square wave voltammetric study of interaction between 9-acridinyl amino acid derivatives and DNA" in Bioelectrochemistry, 149 (2023),
https://doi.org/10.1016/j.bioelechem.2022.108323 . .

TY  - CONF
AU  - Selaković, Milan
AU  - Aleksić, Mara
AU  - Ivković, Branka
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4603
AB  - Ivermectin (IVM) is a drug from the group of anthelmintics used in veterinary and
human medicine. Recently, it has been used in the treatment of some malignant diseases, as
well as viral infections caused by Zika virus, HIV-1, SARS-CoV-2, which has increased the
interest in this medicine (1). Electrochemical characterization of IVM was done with the aim
of better understanding the redox behavior of the molecule, as well as to predict potential
transformations during interactions with other electroactive biomolecules. Electrochemical
behavior was examined by cyclic (CV), differential pulse (DPV) and square wave
voltammetry (SWV) using a glassy carbon electrode (GCE). The effect of pH was examined in
the pH range 2–10. The results confirmed that IVM is electroactive in the entire study area.
IVM shows the main oxidation peak at a potential of about 1.0 V, which is most intense in a
neutral environment, and an additional (weakly expressed) peak, due to oxidation of the
reduced drug form. In voltammograms, there is also a peak of low intensity, which originates
from the reduction of the previously oxidized form of the drug. Based on the shape of the
voltammogram, it is concluded that all these processes are irreversible. The analysis of the
influence of the rate of change of potential (pH 4.6 and 7.0) is also responsible for the
adsorption of the active component on the electrode. The presented results indicate the
advantage of applying electrochemical methods in drug analysis due to low cost, high speed
and ease of execution.
AB  - Ivermektin (IVM) je lek iz grupe antihelmintik koji se primenjuje u veterinarskoj i
humanoj medicini. U novije vreme našao je primenu i kao lek u terapiji nekih malignih
oboljenja, kao i virusnih infekcija prouzrokovanih virusom Zika, HIV-1, SARS-CoV-2 , čime je
ponovo poraslo interesovanje za ovaj lek (1). Elektrohemijska karakterizacija IVM je rađena
sa ciljem boljeg razumevanja redoks ponašanja samog molekula, kao i za predviđanje
potencijalnih transformacija tokom interakcija sa drugim elektroaktivnim lekovima ili
biomolekulima. Elektrohemijsko ponašanje IVM-a ispitivano je cikličnom (CV),
diferencijalnom pulsnom (DPV) i voltametrijom pravougaonih talasa (SWV) korišćenjem
elektrode od staklastog ugljenika (GCE). Uticaj pH na oksidaciju i redukciju IVM ispitan je u
opsegu pH 2–10. Rezultati su potvrdili da je IVM elektroaktivan u celoj ispitivanoj oblasti.
IVM pokazuje glavni oksidacioni pik na potencijalu oko 1,0 V koji je najintenzivniji u
neutralnoj sredini i dodatni (slabo izražen) pik koji je posledica oksidacije redukovanog
oblika leka . U voltamogramima IVM-a javlja se i pik slabog intenziteta koji potiče od
redukcije prethodno oksidovane forme leka. Na osnovu oblika voltamograma zaključuje se
da su svi navedeni procesi ireverzibilni. Analizom uticaja brzine promene potencijala (pH 4,6
i 7,0) određena je priroda redoks procesa: oksidacija IVM-a je difuziono kontrolisan proces,
dok je pored difuzije za redukciju IVM-a odgovorna i adsorpcija aktivne komponente na
elektrodi. Pored svog fundamentalnog značaja, prikazani rezultati ukazuju na prednost
primene elektrohemijskih metoda u analizi lekova zbog niske cene, velike brzine i
jednostavnosti izvođenja.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Ivermectin electrochemical behavoiur at glassy carbon electrode
T1  - Elektrohemijsko ponašanje ivermektina na elektrodi od staklastog ugljenika
VL  - 72
IS  - 4 suplement
SP  - S544
EP  - S545
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4603
ER  - 

@conference{
author = "Selaković, Milan and Aleksić, Mara and Ivković, Branka",
year = "2022",
abstract = "Ivermectin (IVM) is a drug from the group of anthelmintics used in veterinary and
human medicine. Recently, it has been used in the treatment of some malignant diseases, as
well as viral infections caused by Zika virus, HIV-1, SARS-CoV-2, which has increased the
interest in this medicine (1). Electrochemical characterization of IVM was done with the aim
of better understanding the redox behavior of the molecule, as well as to predict potential
transformations during interactions with other electroactive biomolecules. Electrochemical
behavior was examined by cyclic (CV), differential pulse (DPV) and square wave
voltammetry (SWV) using a glassy carbon electrode (GCE). The effect of pH was examined in
the pH range 2–10. The results confirmed that IVM is electroactive in the entire study area.
IVM shows the main oxidation peak at a potential of about 1.0 V, which is most intense in a
neutral environment, and an additional (weakly expressed) peak, due to oxidation of the
reduced drug form. In voltammograms, there is also a peak of low intensity, which originates
from the reduction of the previously oxidized form of the drug. Based on the shape of the
voltammogram, it is concluded that all these processes are irreversible. The analysis of the
influence of the rate of change of potential (pH 4.6 and 7.0) is also responsible for the
adsorption of the active component on the electrode. The presented results indicate the
advantage of applying electrochemical methods in drug analysis due to low cost, high speed
and ease of execution., Ivermektin (IVM) je lek iz grupe antihelmintik koji se primenjuje u veterinarskoj i
humanoj medicini. U novije vreme našao je primenu i kao lek u terapiji nekih malignih
oboljenja, kao i virusnih infekcija prouzrokovanih virusom Zika, HIV-1, SARS-CoV-2 , čime je
ponovo poraslo interesovanje za ovaj lek (1). Elektrohemijska karakterizacija IVM je rađena
sa ciljem boljeg razumevanja redoks ponašanja samog molekula, kao i za predviđanje
potencijalnih transformacija tokom interakcija sa drugim elektroaktivnim lekovima ili
biomolekulima. Elektrohemijsko ponašanje IVM-a ispitivano je cikličnom (CV),
diferencijalnom pulsnom (DPV) i voltametrijom pravougaonih talasa (SWV) korišćenjem
elektrode od staklastog ugljenika (GCE). Uticaj pH na oksidaciju i redukciju IVM ispitan je u
opsegu pH 2–10. Rezultati su potvrdili da je IVM elektroaktivan u celoj ispitivanoj oblasti.
IVM pokazuje glavni oksidacioni pik na potencijalu oko 1,0 V koji je najintenzivniji u
neutralnoj sredini i dodatni (slabo izražen) pik koji je posledica oksidacije redukovanog
oblika leka . U voltamogramima IVM-a javlja se i pik slabog intenziteta koji potiče od
redukcije prethodno oksidovane forme leka. Na osnovu oblika voltamograma zaključuje se
da su svi navedeni procesi ireverzibilni. Analizom uticaja brzine promene potencijala (pH 4,6
i 7,0) određena je priroda redoks procesa: oksidacija IVM-a je difuziono kontrolisan proces,
dok je pored difuzije za redukciju IVM-a odgovorna i adsorpcija aktivne komponente na
elektrodi. Pored svog fundamentalnog značaja, prikazani rezultati ukazuju na prednost
primene elektrohemijskih metoda u analizi lekova zbog niske cene, velike brzine i
jednostavnosti izvođenja.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Ivermectin electrochemical behavoiur at glassy carbon electrode, Elektrohemijsko ponašanje ivermektina na elektrodi od staklastog ugljenika",
volume = "72",
number = "4 suplement",
pages = "S544-S545",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4603"
}

Selaković, M., Aleksić, M.,& Ivković, B.. (2022). Ivermectin electrochemical behavoiur at glassy carbon electrode. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S544-S545.
https://hdl.handle.net/21.15107/rcub_farfar_4603

Selaković M, Aleksić M, Ivković B. Ivermectin electrochemical behavoiur at glassy carbon electrode. in Arhiv za farmaciju. 2022;72(4 suplement):S544-S545.
https://hdl.handle.net/21.15107/rcub_farfar_4603 .

Selaković, Milan, Aleksić, Mara, Ivković, Branka, "Ivermectin electrochemical behavoiur at glassy carbon electrode" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S544-S545,
https://hdl.handle.net/21.15107/rcub_farfar_4603 .

TY  - CONF
AU  - Rupar, Jelena
AU  - Aleksić, Mara
AU  - Dobričić, Vladimir
AU  - Čudina, Olivera
AU  - Brborić, Jasmina
AU  - Gavrilov, Nemanja
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5482
AB  - Oxidation of newly synthesized acridine derivatives was studied using cyclic voltammetry at glassy
carbon electrode. Oxidation occurs as irreversible, diffusion-controlled process at pH 4.6 for
compounds 1-3 and as adsorption controlled process for compound 4. The interaction between newly
synthesized acridine compounds (compounds 1-4) and dsDNA was studied using a multilayer dsDNA
biosensor applying square wave voltammetry. Peak current corresponding to deoxyadenosine
decreased after 30 minutes of interaction suggesting interaction with dsDNA.
PB  - Society of Physical Chemists of Serbia
C3  - Physical Chemistry 2021 (Proceedings), 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 20-24, 2021. Belgrade, Serbia
T1  - Electrochemical oxidation and interaction of newly synthesized acridine derivatives with DNA
VL  - I
SP  - 294
EP  - 297
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5482
ER  - 

@conference{
author = "Rupar, Jelena and Aleksić, Mara and Dobričić, Vladimir and Čudina, Olivera and Brborić, Jasmina and Gavrilov, Nemanja",
year = "2021",
abstract = "Oxidation of newly synthesized acridine derivatives was studied using cyclic voltammetry at glassy
carbon electrode. Oxidation occurs as irreversible, diffusion-controlled process at pH 4.6 for
compounds 1-3 and as adsorption controlled process for compound 4. The interaction between newly
synthesized acridine compounds (compounds 1-4) and dsDNA was studied using a multilayer dsDNA
biosensor applying square wave voltammetry. Peak current corresponding to deoxyadenosine
decreased after 30 minutes of interaction suggesting interaction with dsDNA.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical Chemistry 2021 (Proceedings), 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 20-24, 2021. Belgrade, Serbia",
title = "Electrochemical oxidation and interaction of newly synthesized acridine derivatives with DNA",
volume = "I",
pages = "294-297",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5482"
}

Rupar, J., Aleksić, M., Dobričić, V., Čudina, O., Brborić, J.,& Gavrilov, N.. (2021). Electrochemical oxidation and interaction of newly synthesized acridine derivatives with DNA. in Physical Chemistry 2021 (Proceedings), 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 20-24, 2021. Belgrade, Serbia
Society of Physical Chemists of Serbia., I, 294-297.
https://hdl.handle.net/21.15107/rcub_farfar_5482

Rupar J, Aleksić M, Dobričić V, Čudina O, Brborić J, Gavrilov N. Electrochemical oxidation and interaction of newly synthesized acridine derivatives with DNA. in Physical Chemistry 2021 (Proceedings), 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 20-24, 2021. Belgrade, Serbia. 2021;I:294-297.
https://hdl.handle.net/21.15107/rcub_farfar_5482 .

Rupar, Jelena, Aleksić, Mara, Dobričić, Vladimir, Čudina, Olivera, Brborić, Jasmina, Gavrilov, Nemanja, "Electrochemical oxidation and interaction of newly synthesized acridine derivatives with DNA" in Physical Chemistry 2021 (Proceedings), 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 20-24, 2021. Belgrade, Serbia, I (2021):294-297,
https://hdl.handle.net/21.15107/rcub_farfar_5482 .

TY  - JOUR
AU  - Rupar, Jelena
AU  - Aleksić, Mara
AU  - Dobričić, Vladimir
AU  - Brborić, Jasmina
AU  - Čudina, Olivera
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3611
AB  - The electrochemical behavior of 9-chloroacridine (9Cl-A), a precursor molecule for synthesis of acridine derivatives with cytostatic activity, is a complex, pH-dependent, diffusion-controlled irreversible process. Oxidation of 9Cl-A initiates with the formation of a cation radical monomer, continues via the formation of a dimer subsequent oxidation to new cation radical. Reduction of 9Cl-A produces radical monomers which are stabilized by dimer formation. The investigation was performed using cyclic, differential pulse and square wave voltammetry at a glassy carbon electrode. The interaction between 9Cl-A and double-stranded DNA (dsDNA) was investigated using a multilayer dsDNA-electrochemical biosensor and 9Cl-A solutions from 1.0×10-7M (the lowest 9Cl-A concentration whose interaction with DNA was possible to detect) up to 1×10-4M. These allowed the binding constant, K=3.45×105M-1 and change in Gibbs free energy of the formed adsorbed complex to be calculated. Complex formation was a spontaneous process proceeding via 9Cl-A intercalation into dsDNA inducing structural changes. The intercalation of 9Cl-A into dsDNA was supported by molecular docking analysis. The combination of simple methodology and the use of biosensors to investigate DNA interactions is a powerful tool to offer insight into aspects of drug design during pharmaceutical development.
PB  - Elsevier B.V.
T2  - Bioelectrochemistry
T1  - An electrochemical study of 9-chloroacridine redox behavior and its interaction with double-stranded DNA
VL  - 135
DO  - 10.1016/j.bioelechem.2020.107579
ER  - 

@article{
author = "Rupar, Jelena and Aleksić, Mara and Dobričić, Vladimir and Brborić, Jasmina and Čudina, Olivera",
year = "2020",
abstract = "The electrochemical behavior of 9-chloroacridine (9Cl-A), a precursor molecule for synthesis of acridine derivatives with cytostatic activity, is a complex, pH-dependent, diffusion-controlled irreversible process. Oxidation of 9Cl-A initiates with the formation of a cation radical monomer, continues via the formation of a dimer subsequent oxidation to new cation radical. Reduction of 9Cl-A produces radical monomers which are stabilized by dimer formation. The investigation was performed using cyclic, differential pulse and square wave voltammetry at a glassy carbon electrode. The interaction between 9Cl-A and double-stranded DNA (dsDNA) was investigated using a multilayer dsDNA-electrochemical biosensor and 9Cl-A solutions from 1.0×10-7M (the lowest 9Cl-A concentration whose interaction with DNA was possible to detect) up to 1×10-4M. These allowed the binding constant, K=3.45×105M-1 and change in Gibbs free energy of the formed adsorbed complex to be calculated. Complex formation was a spontaneous process proceeding via 9Cl-A intercalation into dsDNA inducing structural changes. The intercalation of 9Cl-A into dsDNA was supported by molecular docking analysis. The combination of simple methodology and the use of biosensors to investigate DNA interactions is a powerful tool to offer insight into aspects of drug design during pharmaceutical development.",
publisher = "Elsevier B.V.",
journal = "Bioelectrochemistry",
title = "An electrochemical study of 9-chloroacridine redox behavior and its interaction with double-stranded DNA",
volume = "135",
doi = "10.1016/j.bioelechem.2020.107579"
}

Rupar, J., Aleksić, M., Dobričić, V., Brborić, J.,& Čudina, O.. (2020). An electrochemical study of 9-chloroacridine redox behavior and its interaction with double-stranded DNA. in Bioelectrochemistry
Elsevier B.V.., 135.
https://doi.org/10.1016/j.bioelechem.2020.107579

Rupar J, Aleksić M, Dobričić V, Brborić J, Čudina O. An electrochemical study of 9-chloroacridine redox behavior and its interaction with double-stranded DNA. in Bioelectrochemistry. 2020;135.
doi:10.1016/j.bioelechem.2020.107579 .

Rupar, Jelena, Aleksić, Mara, Dobričić, Vladimir, Brborić, Jasmina, Čudina, Olivera, "An electrochemical study of 9-chloroacridine redox behavior and its interaction with double-stranded DNA" in Bioelectrochemistry, 135 (2020),
https://doi.org/10.1016/j.bioelechem.2020.107579 . .

TY  - JOUR
AU  - Rupar, Jelena
AU  - Dobričić, Vladimir
AU  - Grahovac, Jelena
AU  - Radulović, Siniša
AU  - Skok, Žiga
AU  - Ilaš, Janez
AU  - Aleksić, Mara
AU  - Brborić, Jasmina
AU  - Čudina, Olivera
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3606
AB  - A series of eleven 9-acridinyl amino acid derivatives were synthesized using a two-step procedure. Cytotoxicity was tested on the K562 and A549 cancer cell lines and normal diploid cell line MRC5 using the MTT assay. Compounds 6, 7, 8 and 9 were the most active, with IC50 values comparable to or lower than that of chemotherapeutic agent amsacrine. 8 and 9 were especially effective in the A549 cell line (IC50 ≈ 6 μM), which is of special interest since amsacrine is not sufficiently active in lung cancer patients. Cell cycle analysis revealed that 7 and 9 caused G2/M block, amsacrine caused arrest in the S phase, while 6 and 8 induced apoptotic cell death independently of the cell cycle regulation. In comparison to amsacrine, 6, 7, 8, and 9 showed similar inhibitory potential towards topoisomerase II, whereas only 7 showed DNA intercalation properties. In contrast to amsacrine, 6, 7, 8 and 9 showed a lack of toxicity towards unstimulated normal human leucocytes.
PB  - Royal Society of Chemistry
T2  - RSC Medicinal Chemistry
T1  - Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives
VL  - 11
IS  - 3
SP  - 378
EP  - 386
DO  - 10.1039/c9md00597h
DO  - 2-s2.0-85083014447
ER  - 

@article{
author = "Rupar, Jelena and Dobričić, Vladimir and Grahovac, Jelena and Radulović, Siniša and Skok, Žiga and Ilaš, Janez and Aleksić, Mara and Brborić, Jasmina and Čudina, Olivera",
year = "2020",
abstract = "A series of eleven 9-acridinyl amino acid derivatives were synthesized using a two-step procedure. Cytotoxicity was tested on the K562 and A549 cancer cell lines and normal diploid cell line MRC5 using the MTT assay. Compounds 6, 7, 8 and 9 were the most active, with IC50 values comparable to or lower than that of chemotherapeutic agent amsacrine. 8 and 9 were especially effective in the A549 cell line (IC50 ≈ 6 μM), which is of special interest since amsacrine is not sufficiently active in lung cancer patients. Cell cycle analysis revealed that 7 and 9 caused G2/M block, amsacrine caused arrest in the S phase, while 6 and 8 induced apoptotic cell death independently of the cell cycle regulation. In comparison to amsacrine, 6, 7, 8, and 9 showed similar inhibitory potential towards topoisomerase II, whereas only 7 showed DNA intercalation properties. In contrast to amsacrine, 6, 7, 8 and 9 showed a lack of toxicity towards unstimulated normal human leucocytes.",
publisher = "Royal Society of Chemistry",
journal = "RSC Medicinal Chemistry",
title = "Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives",
volume = "11",
number = "3",
pages = "378-386",
doi = "10.1039/c9md00597h, 2-s2.0-85083014447"
}

Rupar, J., Dobričić, V., Grahovac, J., Radulović, S., Skok, Ž., Ilaš, J., Aleksić, M., Brborić, J.,& Čudina, O.. (2020). Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives. in RSC Medicinal Chemistry
Royal Society of Chemistry., 11(3), 378-386.
https://doi.org/10.1039/c9md00597h

Rupar J, Dobričić V, Grahovac J, Radulović S, Skok Ž, Ilaš J, Aleksić M, Brborić J, Čudina O. Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives. in RSC Medicinal Chemistry. 2020;11(3):378-386.
doi:10.1039/c9md00597h .

Rupar, Jelena, Dobričić, Vladimir, Grahovac, Jelena, Radulović, Siniša, Skok, Žiga, Ilaš, Janez, Aleksić, Mara, Brborić, Jasmina, Čudina, Olivera, "Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives" in RSC Medicinal Chemistry, 11, no. 3 (2020):378-386,
https://doi.org/10.1039/c9md00597h . .

TY  - JOUR
AU  - Radulović, Valentina
AU  - Aleksić, Mara
AU  - Kapetanović, Vera
AU  - Rajić, K.K
AU  - Jovanović, M
AU  - Marjanović, I
AU  - Stojković, M
AU  - Agbaba, Danica
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3286
AB  - A novel voltammetric method was developed for brimonidine (BRIM) determination in deproteinized aqueous humor, simplifying preparation of biological samples for analysis for stability studies. The differential pulse voltammetric (DPV) method using boron doped diamond electrode (BDDE), based on characteristic oxidation peaks, was proposed and successfully applied. The linearity range was within 5.0 × 10−6 to 5.0 × 10−5 M of brimonidine, and limit of detection and limit of quantitation were 1.94 × 10−6 M and 6.46 × 10−6 M, respectively. Intra-day and inter-day precision and accuracy were evaluated and all results were in accordance with validation ICH guidelines. The best short-term stability study results were obtained for a concentration level of 3.0 × 10−5 M expressed by deviation of + 1.86% between initial and post storage concentrations. A long-term stability study was performed for two concentrations of 3.0 × 10−5 M and 5.0 × 10−5 M and resulted in deviations of + 1.63% and + 3.56%, respectively. A freeze and thaw stability study indicated that samples might be frozen only once. The enhancement of DPV/BDDE method sensitivity gained by modification, for the analysis of immeasurable BRIM quantities in native, untreated aqueous humor, was reached for quantities of 6 or 12 nmol/0.1 mL aqueous humor with acceptable accuracy (up to + 7.5%). The nature of the process—the irreversible one electron oxidation voltammetric peak of BRIM—limited the sensitivity. Only electrochemical pre-treatment of the BDD electrode before each measurement significantly speeded up the whole procedure. The advantages of the proposed method are simplicity, short-time performance, and good specificity/selectivity, as well as satisfactory accuracy, and no chemical modification of BDDE was necessary.
PB  - Springer Verlag
T2  - Analytical and Bioanalytical Chemistry
T1  - The evaluation of short- and long-term stability studies for brimonidine in aqueous humor by DPV/BDDE method—possible application for direct assay in native samples
DO  - 10.1007/s00216-019-01955-3
ER  - 

@article{
author = "Radulović, Valentina and Aleksić, Mara and Kapetanović, Vera and Rajić, K.K and Jovanović, M and Marjanović, I and Stojković, M and Agbaba, Danica",
year = "2019",
abstract = "A novel voltammetric method was developed for brimonidine (BRIM) determination in deproteinized aqueous humor, simplifying preparation of biological samples for analysis for stability studies. The differential pulse voltammetric (DPV) method using boron doped diamond electrode (BDDE), based on characteristic oxidation peaks, was proposed and successfully applied. The linearity range was within 5.0 × 10−6 to 5.0 × 10−5 M of brimonidine, and limit of detection and limit of quantitation were 1.94 × 10−6 M and 6.46 × 10−6 M, respectively. Intra-day and inter-day precision and accuracy were evaluated and all results were in accordance with validation ICH guidelines. The best short-term stability study results were obtained for a concentration level of 3.0 × 10−5 M expressed by deviation of + 1.86% between initial and post storage concentrations. A long-term stability study was performed for two concentrations of 3.0 × 10−5 M and 5.0 × 10−5 M and resulted in deviations of + 1.63% and + 3.56%, respectively. A freeze and thaw stability study indicated that samples might be frozen only once. The enhancement of DPV/BDDE method sensitivity gained by modification, for the analysis of immeasurable BRIM quantities in native, untreated aqueous humor, was reached for quantities of 6 or 12 nmol/0.1 mL aqueous humor with acceptable accuracy (up to + 7.5%). The nature of the process—the irreversible one electron oxidation voltammetric peak of BRIM—limited the sensitivity. Only electrochemical pre-treatment of the BDD electrode before each measurement significantly speeded up the whole procedure. The advantages of the proposed method are simplicity, short-time performance, and good specificity/selectivity, as well as satisfactory accuracy, and no chemical modification of BDDE was necessary.",
publisher = "Springer Verlag",
journal = "Analytical and Bioanalytical Chemistry",
title = "The evaluation of short- and long-term stability studies for brimonidine in aqueous humor by DPV/BDDE method—possible application for direct assay in native samples",
doi = "10.1007/s00216-019-01955-3"
}

Radulović, V., Aleksić, M., Kapetanović, V., Rajić, K.K, Jovanović, M., Marjanović, I., Stojković, M.,& Agbaba, D.. (2019). The evaluation of short- and long-term stability studies for brimonidine in aqueous humor by DPV/BDDE method—possible application for direct assay in native samples. in Analytical and Bioanalytical Chemistry
Springer Verlag..
https://doi.org/10.1007/s00216-019-01955-3

Radulović V, Aleksić M, Kapetanović V, Rajić K, Jovanović M, Marjanović I, Stojković M, Agbaba D. The evaluation of short- and long-term stability studies for brimonidine in aqueous humor by DPV/BDDE method—possible application for direct assay in native samples. in Analytical and Bioanalytical Chemistry. 2019;.
doi:10.1007/s00216-019-01955-3 .

Radulović, Valentina, Aleksić, Mara, Kapetanović, Vera, Rajić, K.K, Jovanović, M, Marjanović, I, Stojković, M, Agbaba, Danica, "The evaluation of short- and long-term stability studies for brimonidine in aqueous humor by DPV/BDDE method—possible application for direct assay in native samples" in Analytical and Bioanalytical Chemistry (2019),
https://doi.org/10.1007/s00216-019-01955-3 . .

TY  - JOUR
AU  - Rupar, Jelena
AU  - Aleksić, Mara
AU  - Nikolić, Katarina
AU  - Popović-Nikolić, Marija
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3145
AB  - The electrochemical response of two biologically important benzopyrazine derivative, Quinoxaline and Brimonidine (5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl) quinoxaline-6-amine) was studied at glassy carbon electrode. Investigations were performed in acetate buffer at pH 3.6 where both compounds undergo complex electrode process which begins with quasi reversible redox process at pyrazine ring forming di-hydro derivative, which is further irreversible oxidized to hydroxyl-derivative. Cyclic voltammetry at different scan rates was employed for the determination of heterogeneous electron transfer rate constant and diffusion coefficient of the compounds. The values of electron transfer rate constant at different temperatures were used for the evaluation of thermodynamic parameters like enthalpy, entropy and Gibbs free energy changes, as well as apparent energy of activation. Computational study has been performed in order to evaluate some useful quantum chemical parameters with the aim to confirm and explain the difference in experimentally obtained kinetic and thermodynamic parameters of the investigated QUI and BRIM redox process. Results were compared with studies of similar compounds and pointed out the observed similarities and differences.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Electrochimica Acta
T1  - Comparative electrochemical studies of kinetic and thermodynamic parameters of Quinoxaline and Brimonidine redox process
VL  - 271
SP  - 220
EP  - 231
DO  - 10.1016/j.electacta.2018.03.114
ER  - 

@article{
author = "Rupar, Jelena and Aleksić, Mara and Nikolić, Katarina and Popović-Nikolić, Marija",
year = "2018",
abstract = "The electrochemical response of two biologically important benzopyrazine derivative, Quinoxaline and Brimonidine (5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl) quinoxaline-6-amine) was studied at glassy carbon electrode. Investigations were performed in acetate buffer at pH 3.6 where both compounds undergo complex electrode process which begins with quasi reversible redox process at pyrazine ring forming di-hydro derivative, which is further irreversible oxidized to hydroxyl-derivative. Cyclic voltammetry at different scan rates was employed for the determination of heterogeneous electron transfer rate constant and diffusion coefficient of the compounds. The values of electron transfer rate constant at different temperatures were used for the evaluation of thermodynamic parameters like enthalpy, entropy and Gibbs free energy changes, as well as apparent energy of activation. Computational study has been performed in order to evaluate some useful quantum chemical parameters with the aim to confirm and explain the difference in experimentally obtained kinetic and thermodynamic parameters of the investigated QUI and BRIM redox process. Results were compared with studies of similar compounds and pointed out the observed similarities and differences.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Electrochimica Acta",
title = "Comparative electrochemical studies of kinetic and thermodynamic parameters of Quinoxaline and Brimonidine redox process",
volume = "271",
pages = "220-231",
doi = "10.1016/j.electacta.2018.03.114"
}

Rupar, J., Aleksić, M., Nikolić, K.,& Popović-Nikolić, M.. (2018). Comparative electrochemical studies of kinetic and thermodynamic parameters of Quinoxaline and Brimonidine redox process. in Electrochimica Acta
Pergamon-Elsevier Science Ltd, Oxford., 271, 220-231.
https://doi.org/10.1016/j.electacta.2018.03.114

Rupar J, Aleksić M, Nikolić K, Popović-Nikolić M. Comparative electrochemical studies of kinetic and thermodynamic parameters of Quinoxaline and Brimonidine redox process. in Electrochimica Acta. 2018;271:220-231.
doi:10.1016/j.electacta.2018.03.114 .

Rupar, Jelena, Aleksić, Mara, Nikolić, Katarina, Popović-Nikolić, Marija, "Comparative electrochemical studies of kinetic and thermodynamic parameters of Quinoxaline and Brimonidine redox process" in Electrochimica Acta, 271 (2018):220-231,
https://doi.org/10.1016/j.electacta.2018.03.114 . .

TY  - JOUR
AU  - Rupar, Jelena
AU  - Dobričić, Vladimir
AU  - Aleksić, Mara
AU  - Brborić, Jasmina
AU  - Čudina, Olivera
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3033
AB  - Acridine ring can be found in molecules used in many different spheres, including industry and medicine. Nowadays, even acridines with antibacterial activity are of research interest due to increasing bacterial resistance. Some acridine derivatives showed antimalarial or antiviral activity. Acridine derivatives were also investigated for antitumor activity due to the interaction with topoisomerase II and DNA base pairs. Considering these possible uses of acridine derivatives, this work was made as overview of all significant structure characteristics for specific action of these compounds.
PB  - Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac
T2  - Kragujevac Journal of Science
T1  - A review of published data on acridine derivatives with different biological activities
IS  - 40
SP  - 83
EP  - 101
DO  - 10.5937/KgJSci1840083R
ER  - 

@article{
author = "Rupar, Jelena and Dobričić, Vladimir and Aleksić, Mara and Brborić, Jasmina and Čudina, Olivera",
year = "2018",
abstract = "Acridine ring can be found in molecules used in many different spheres, including industry and medicine. Nowadays, even acridines with antibacterial activity are of research interest due to increasing bacterial resistance. Some acridine derivatives showed antimalarial or antiviral activity. Acridine derivatives were also investigated for antitumor activity due to the interaction with topoisomerase II and DNA base pairs. Considering these possible uses of acridine derivatives, this work was made as overview of all significant structure characteristics for specific action of these compounds.",
publisher = "Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac",
journal = "Kragujevac Journal of Science",
title = "A review of published data on acridine derivatives with different biological activities",
number = "40",
pages = "83-101",
doi = "10.5937/KgJSci1840083R"
}

Rupar, J., Dobričić, V., Aleksić, M., Brborić, J.,& Čudina, O.. (2018). A review of published data on acridine derivatives with different biological activities. in Kragujevac Journal of Science
Univerzitet u Kragujevcu - Prirodno-matematički fakultet, Kragujevac.(40), 83-101.
https://doi.org/10.5937/KgJSci1840083R

Rupar J, Dobričić V, Aleksić M, Brborić J, Čudina O. A review of published data on acridine derivatives with different biological activities. in Kragujevac Journal of Science. 2018;(40):83-101.
doi:10.5937/KgJSci1840083R .

Rupar, Jelena, Dobričić, Vladimir, Aleksić, Mara, Brborić, Jasmina, Čudina, Olivera, "A review of published data on acridine derivatives with different biological activities" in Kragujevac Journal of Science, no. 40 (2018):83-101,
https://doi.org/10.5937/KgJSci1840083R . .

TY  - CONF
AU  - Pantić, Jelena
AU  - Aleksić, Mara
AU  - Kapetanović, Vera
AU  - Ružić, Dušan
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4923
AB  - Electrochemical behavior of sulfaquinoxaline (SQN) was investigated using cyclic (CV) and differential pulse voltammetry (DPV) at glassy carbon electrode (GCE). CV was applied to investigate the effect of the supporting electrolyte pH on the SQN electrochemical behavior. In the pH range 2.0 – 10.0, the best current response was obtained at pH 7.0 in phosphate buffer. Results indicated that SQN is oxidized in irreversible process. DPV method was optimized, and the linear dependence of peak current vs. SQN concentration was obtained in the range 3×10-6 ‒ 5×10-5 molL-1, with limits of detection and quantification of 1.53×10-6 molL-1 and 5.10×10-6 molL-1, respectively. DPV was successively applied for SQN determination in veterinary medicine NEOCOCCYN WSP, which contains amprolium hydrochloride, as active component too.
PB  - Society of Physical Chemists of Serbia
C3  - PHYSICAL CHEMISTRY 2016 (Proceedings) 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia
T1  - Electrochemical behavior and determination od sulfaquinoxaline at glassy carbon electrode
VL  - II
SP  - 829
EP  - 832
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4923
ER  - 

@conference{
author = "Pantić, Jelena and Aleksić, Mara and Kapetanović, Vera and Ružić, Dušan",
year = "2016",
abstract = "Electrochemical behavior of sulfaquinoxaline (SQN) was investigated using cyclic (CV) and differential pulse voltammetry (DPV) at glassy carbon electrode (GCE). CV was applied to investigate the effect of the supporting electrolyte pH on the SQN electrochemical behavior. In the pH range 2.0 – 10.0, the best current response was obtained at pH 7.0 in phosphate buffer. Results indicated that SQN is oxidized in irreversible process. DPV method was optimized, and the linear dependence of peak current vs. SQN concentration was obtained in the range 3×10-6 ‒ 5×10-5 molL-1, with limits of detection and quantification of 1.53×10-6 molL-1 and 5.10×10-6 molL-1, respectively. DPV was successively applied for SQN determination in veterinary medicine NEOCOCCYN WSP, which contains amprolium hydrochloride, as active component too.",
publisher = "Society of Physical Chemists of Serbia",
journal = "PHYSICAL CHEMISTRY 2016 (Proceedings) 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia",
title = "Electrochemical behavior and determination od sulfaquinoxaline at glassy carbon electrode",
volume = "II",
pages = "829-832",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4923"
}

Pantić, J., Aleksić, M., Kapetanović, V.,& Ružić, D.. (2016). Electrochemical behavior and determination od sulfaquinoxaline at glassy carbon electrode. in PHYSICAL CHEMISTRY 2016 (Proceedings) 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia
Society of Physical Chemists of Serbia., II, 829-832.
https://hdl.handle.net/21.15107/rcub_farfar_4923

Pantić J, Aleksić M, Kapetanović V, Ružić D. Electrochemical behavior and determination od sulfaquinoxaline at glassy carbon electrode. in PHYSICAL CHEMISTRY 2016 (Proceedings) 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia. 2016;II:829-832.
https://hdl.handle.net/21.15107/rcub_farfar_4923 .

Pantić, Jelena, Aleksić, Mara, Kapetanović, Vera, Ružić, Dušan, "Electrochemical behavior and determination od sulfaquinoxaline at glassy carbon electrode" in PHYSICAL CHEMISTRY 2016 (Proceedings) 13th International Conference on Fundamental and Applied Aspects of Physical Chemistry, September 26-30, 2016, Belgrade, Serbia, II (2016):829-832,
https://hdl.handle.net/21.15107/rcub_farfar_4923 .

TY  - JOUR
AU  - Nikolić, Katarina
AU  - Aleksić, Mara
AU  - Kapetanović, Vera
AU  - Agbaba, Danica
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2300
AB  - The adsorption and electroreduction behavior of cefpodoxime proxetil, cefotaxime, desacetylcefotaxime, cefetamet, ceftriaxone, ceftazidime, and cefuroxime axetil at a mercury electrode surface were studied using cyclic (CV), differential pulse (DPV) and adsorptive stripping differential pulse (AdSDPV) voltammetry. The quantitative structure property relationship (QSPR) study of the seven cephalosporins adsorption at the mercury electrode was based on density functional theory DFT-B3LYP/6-31G(d,p) calculations of molecular orbitals, partial charges and electron densities of the analytes. The DFT-parameters and QSPR model explain well the process of adsorption of the examined cephalosporins. The QSPR study defined that cephalosporins with lower electron density on the nitrogen atom of the N-O bond, higher number of hydrogen bond-accepting groups, and higher principal moment of inertia should express high adsorption on the mercury electrode.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Voltammetric and theoretical studies of the electrochemical behavior of cephalosporins at a mercury electrode
VL  - 80
IS  - 8
SP  - 1035
EP  - 1049
DO  - 10.2298/JSC150129019N
ER  - 

@article{
author = "Nikolić, Katarina and Aleksić, Mara and Kapetanović, Vera and Agbaba, Danica",
year = "2015",
abstract = "The adsorption and electroreduction behavior of cefpodoxime proxetil, cefotaxime, desacetylcefotaxime, cefetamet, ceftriaxone, ceftazidime, and cefuroxime axetil at a mercury electrode surface were studied using cyclic (CV), differential pulse (DPV) and adsorptive stripping differential pulse (AdSDPV) voltammetry. The quantitative structure property relationship (QSPR) study of the seven cephalosporins adsorption at the mercury electrode was based on density functional theory DFT-B3LYP/6-31G(d,p) calculations of molecular orbitals, partial charges and electron densities of the analytes. The DFT-parameters and QSPR model explain well the process of adsorption of the examined cephalosporins. The QSPR study defined that cephalosporins with lower electron density on the nitrogen atom of the N-O bond, higher number of hydrogen bond-accepting groups, and higher principal moment of inertia should express high adsorption on the mercury electrode.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Voltammetric and theoretical studies of the electrochemical behavior of cephalosporins at a mercury electrode",
volume = "80",
number = "8",
pages = "1035-1049",
doi = "10.2298/JSC150129019N"
}

Nikolić, K., Aleksić, M., Kapetanović, V.,& Agbaba, D.. (2015). Voltammetric and theoretical studies of the electrochemical behavior of cephalosporins at a mercury electrode. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 80(8), 1035-1049.
https://doi.org/10.2298/JSC150129019N

Nikolić K, Aleksić M, Kapetanović V, Agbaba D. Voltammetric and theoretical studies of the electrochemical behavior of cephalosporins at a mercury electrode. in Journal of the Serbian Chemical Society. 2015;80(8):1035-1049.
doi:10.2298/JSC150129019N .

Nikolić, Katarina, Aleksić, Mara, Kapetanović, Vera, Agbaba, Danica, "Voltammetric and theoretical studies of the electrochemical behavior of cephalosporins at a mercury electrode" in Journal of the Serbian Chemical Society, 80, no. 8 (2015):1035-1049,
https://doi.org/10.2298/JSC150129019N . .

TY  - JOUR
AU  - Aleksić, Mara
AU  - Pantić, Jelena
AU  - Kapetanović, Vera
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2295
AB  - The electrochemical behavior of a biologically important heterocyclic compound quinoxaline (QUI) was investigated by cyclic voltammetry (CV) in solutions of differing pH, using a glassy carbon electrode (GCE). The reduction of QUI occurs as a quasi-reversible reaction in acid medium, reaching reversibility in alkaline solutions. The kinetic parameters of the electrode process such as αnα, diffusion coefficient (D) and heterogeneous rate constant (ks), were evaluated and discussed. Redox mechanism of QUI was proposed on the basis of experimental results. Reduction process involves a transfer of two electrons and two protons at the pyrazine ring of QUI forming a dihydro-derivative. In acid solutions, the product of QUI reduction undergoes irreversible oxidation in a one-electron process. The electrode processes was found to be diffusion controlled.
AB  - Elektrohemijsko ponašanje biološki značajnog heterocikličnog jedinjenja hinoksalina (QUI) ispitivano je cikličnom voltametrijom (CV) u rastvorima različitih pH vrednosti, korišćenjem electrode odstaklastog ugljenika. Redukcija QUI u kiseloj sredini se odigrava kao kvazi-reverzibilna reakcija, koja u baznoj sredini postaje reverzibilna. Određeni su i razmatrani kinetički parametric elektrodnog procesa kao što su koeficijent αnα, difuzioni koeficijent (D) i konstanta brzine (ks). Na osnovu eksperimentalnih rezultata predložen je mehanizam elektrodne reakcije. U procesu redukcije adiraju se dva elektrona i dva protona na pirazinski prsten hinoksalina i nastaje njegov dihidro derivat. Proizvod redukcije hinoksalina u kiseloj sredini se dalje oksiduje. Ovaj process oksidacije je difuziono kontrolisan, ireverzibilan i odigrava se uz učešće jednog elektrona i jednog protona.
PB  - Univerzitet u Nišu, Niš
T2  - Facta universitatis - series: Physics, Chemistry and Technology
T1  - Evaluation of kinetic parameters and redox mechanism of quinoxaline at glassy carbon electrode
T1  - Određivanje kinetičkih parametara i ispitivanje redoks mehanizma hinoksalina na elektrodi od staklastog ugljenika
VL  - 12
IS  - 1
SP  - 55
EP  - 63
DO  - 10.2298/FUPCT1401055A
ER  - 

@article{
author = "Aleksić, Mara and Pantić, Jelena and Kapetanović, Vera",
year = "2014",
abstract = "The electrochemical behavior of a biologically important heterocyclic compound quinoxaline (QUI) was investigated by cyclic voltammetry (CV) in solutions of differing pH, using a glassy carbon electrode (GCE). The reduction of QUI occurs as a quasi-reversible reaction in acid medium, reaching reversibility in alkaline solutions. The kinetic parameters of the electrode process such as αnα, diffusion coefficient (D) and heterogeneous rate constant (ks), were evaluated and discussed. Redox mechanism of QUI was proposed on the basis of experimental results. Reduction process involves a transfer of two electrons and two protons at the pyrazine ring of QUI forming a dihydro-derivative. In acid solutions, the product of QUI reduction undergoes irreversible oxidation in a one-electron process. The electrode processes was found to be diffusion controlled., Elektrohemijsko ponašanje biološki značajnog heterocikličnog jedinjenja hinoksalina (QUI) ispitivano je cikličnom voltametrijom (CV) u rastvorima različitih pH vrednosti, korišćenjem electrode odstaklastog ugljenika. Redukcija QUI u kiseloj sredini se odigrava kao kvazi-reverzibilna reakcija, koja u baznoj sredini postaje reverzibilna. Određeni su i razmatrani kinetički parametric elektrodnog procesa kao što su koeficijent αnα, difuzioni koeficijent (D) i konstanta brzine (ks). Na osnovu eksperimentalnih rezultata predložen je mehanizam elektrodne reakcije. U procesu redukcije adiraju se dva elektrona i dva protona na pirazinski prsten hinoksalina i nastaje njegov dihidro derivat. Proizvod redukcije hinoksalina u kiseloj sredini se dalje oksiduje. Ovaj process oksidacije je difuziono kontrolisan, ireverzibilan i odigrava se uz učešće jednog elektrona i jednog protona.",
publisher = "Univerzitet u Nišu, Niš",
journal = "Facta universitatis - series: Physics, Chemistry and Technology",
title = "Evaluation of kinetic parameters and redox mechanism of quinoxaline at glassy carbon electrode, Određivanje kinetičkih parametara i ispitivanje redoks mehanizma hinoksalina na elektrodi od staklastog ugljenika",
volume = "12",
number = "1",
pages = "55-63",
doi = "10.2298/FUPCT1401055A"
}

Aleksić, M., Pantić, J.,& Kapetanović, V.. (2014). Evaluation of kinetic parameters and redox mechanism of quinoxaline at glassy carbon electrode. in Facta universitatis - series: Physics, Chemistry and Technology
Univerzitet u Nišu, Niš., 12(1), 55-63.
https://doi.org/10.2298/FUPCT1401055A

Aleksić M, Pantić J, Kapetanović V. Evaluation of kinetic parameters and redox mechanism of quinoxaline at glassy carbon electrode. in Facta universitatis - series: Physics, Chemistry and Technology. 2014;12(1):55-63.
doi:10.2298/FUPCT1401055A .

Aleksić, Mara, Pantić, Jelena, Kapetanović, Vera, "Evaluation of kinetic parameters and redox mechanism of quinoxaline at glassy carbon electrode" in Facta universitatis - series: Physics, Chemistry and Technology, 12, no. 1 (2014):55-63,
https://doi.org/10.2298/FUPCT1401055A . .

TY  - JOUR
AU  - Aleksić, Mara
AU  - Kapetanović, Vera
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2138
AB  - A large number of inorganic and organic compounds is able to bind to DNA and form complexes. Among them, drugs are very important, especially chemotherapeutics. This paper presents the overview of DNA structural characteristics and types of interactions (covalent and non-covalent) between DNA molecule and drugs. Covalent binding of the drug is irreversible and leads to complete inhibition of DNA function, what conclusively, causes the cell death. On the other hand, non-covalent binding is reversible and based on the principle of molecular recognition. Special attention is given to elucidation of the specific sites in DNA molecule for drug binding. According to their structural characteristics, drugs that react non-covalently with DNA are mainly intercalators, but also minor and major groove binders. When the complex between drug and DNA is formed, both the drug molecule, as well as DNA, experienced some modifications. This paper presents the overview of the methods used for the study of the interactions between DNA and drugs with the aim of detection and explanation of the resulting changes. For this purpose many spectroscopic methods like UV/VIS, fluorescence, infrared and NMR, polarized light spectroscopies like circular and linear dichroism, and fluorescence anisotropy or resonance is used. The development of the electrochemical DNA biosensors has opened a wide perspective using particularly sensitive and selective electrochemical methods for the detection of specific DNA interactions. The presented results summarize literature data obtained by the mentioned methods. The results are used to confirm the DNA damage, to determine drug binding sites and sequence preference, as well as conformational changes due to drug-DNA interaction.
PB  - Slovensko Kemijsko Drustvo, Ljubljana
T2  - Acta Chimica Slovenica
T1  - An Overview of the Optical and Electrochemical Methods for Detection of DNA - Drug Interactions
VL  - 61
IS  - 3
SP  - 555
EP  - 573
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2138
ER  - 

@article{
author = "Aleksić, Mara and Kapetanović, Vera",
year = "2014",
abstract = "A large number of inorganic and organic compounds is able to bind to DNA and form complexes. Among them, drugs are very important, especially chemotherapeutics. This paper presents the overview of DNA structural characteristics and types of interactions (covalent and non-covalent) between DNA molecule and drugs. Covalent binding of the drug is irreversible and leads to complete inhibition of DNA function, what conclusively, causes the cell death. On the other hand, non-covalent binding is reversible and based on the principle of molecular recognition. Special attention is given to elucidation of the specific sites in DNA molecule for drug binding. According to their structural characteristics, drugs that react non-covalently with DNA are mainly intercalators, but also minor and major groove binders. When the complex between drug and DNA is formed, both the drug molecule, as well as DNA, experienced some modifications. This paper presents the overview of the methods used for the study of the interactions between DNA and drugs with the aim of detection and explanation of the resulting changes. For this purpose many spectroscopic methods like UV/VIS, fluorescence, infrared and NMR, polarized light spectroscopies like circular and linear dichroism, and fluorescence anisotropy or resonance is used. The development of the electrochemical DNA biosensors has opened a wide perspective using particularly sensitive and selective electrochemical methods for the detection of specific DNA interactions. The presented results summarize literature data obtained by the mentioned methods. The results are used to confirm the DNA damage, to determine drug binding sites and sequence preference, as well as conformational changes due to drug-DNA interaction.",
publisher = "Slovensko Kemijsko Drustvo, Ljubljana",
journal = "Acta Chimica Slovenica",
title = "An Overview of the Optical and Electrochemical Methods for Detection of DNA - Drug Interactions",
volume = "61",
number = "3",
pages = "555-573",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2138"
}

Aleksić, M.,& Kapetanović, V.. (2014). An Overview of the Optical and Electrochemical Methods for Detection of DNA - Drug Interactions. in Acta Chimica Slovenica
Slovensko Kemijsko Drustvo, Ljubljana., 61(3), 555-573.
https://hdl.handle.net/21.15107/rcub_farfar_2138

Aleksić M, Kapetanović V. An Overview of the Optical and Electrochemical Methods for Detection of DNA - Drug Interactions. in Acta Chimica Slovenica. 2014;61(3):555-573.
https://hdl.handle.net/21.15107/rcub_farfar_2138 .

Aleksić, Mara, Kapetanović, Vera, "An Overview of the Optical and Electrochemical Methods for Detection of DNA - Drug Interactions" in Acta Chimica Slovenica, 61, no. 3 (2014):555-573,
https://hdl.handle.net/21.15107/rcub_farfar_2138 .

TY  - JOUR
AU  - Aleksić, Mara
AU  - Kapetanović, Vera
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2017
AB  - Large number of inorganic and organic compounds is able to bind to DNA and form the complex. Among them, very important drugs are chemotherapeutics. This paper presents the overview of DNA structural characteristics and types of interactions (covalent and noncovalent) between drugs and DNA molecule. Covalent binding of the drug is irreversible and leads to complete inhibition of DNA function, what conclusively, causes the cell death. On the other hand, noncovalent binding is reversible and based on the principle of molecular recognition. Special attention is paid to explain the specific sites in DNA molecule for drug binding. According to their structural characteristics, drugs that react noncovalently with DNA are intercalators, minor or major groove binders. When the complex between drug and DNA is formed, both the drug molecule, as well as DNA, experienced some modifications. This paper presents the overview of the methods used for the investigation of the interactions between drug and DNA with the aim of detection and explanation of the resulting changes. For this purpose many spectroscopic methods like UV/VIS, infrared and NMR, polarized light spectroscopies like circular and linear dichroism, fluorescence anisotropy or resonance, or very sensitive DNA-biosensors are used. The presented results summarize literature data obtained by the use of mentioned methods. The results are used to confirm the DNA damage, to determine drug binding sites and sequence preference, as well as conformational changes due to drug-DNA interaction.
AB  - Komplekse sa dezoksiribonukleinskom kiselinom (DNK) gradi veliki broj neorganskih i organskih jedinjenja, među kojima su od posebnog značaja lekovi iz grupe hemioterapeutika. U radu je dat pregled strukturnih karakteristika DNK molekula i tipova interakcije (kovalentne i nekovalentne) koje se javljaju između molekula leka i DNK. Kovalentno vezivanje leka za DNK je ireverzibilno i vodi ka kompletnoj inhibiciji funkcija DNK što dovodi do smrti ćelije, dok je nekovalentno vezivanje reverzibilno i zasniva se na principu molekularnog prepoznavanja. Posebna pažnja je posvećena objašnjenju specifičnih mesta u molekulu DNK Na kojima dolazi do vezivanja leka, u zavisnosti od strukturnih karakteristika molekula leka. Najveći broj lekova koji reaguju nekovalentno su interkalatni agensi, a pored njih postoje i lekovi koji se vezuju za mali ili veliki žljeb molekula DNK. Prilikom građenja ovih kompleksa nastaju promene kako na molekulu DNK tako i na molekulu leka. U radu je dat pregled metoda koje se koriste u ispitivanju interakcija između leka i DNK sa ciljem detekcije i objašnjenja nastalih promena. U ovu svrhu koriste se spektroskopske metode, kao što su UV/VIS, infracrvena, ramanska i NMR spektroskopija, zatim spektroskopije polarizovane svetlosti: metode linearnog i cirkularnog dihroizma, fluorescentne anizotropije ili rezonancije, a u novije vreme i osetljivi DNK-biosenzori. Predstavljeni su literaturni rezultati dobijeni primenom navedenih metoda koji se koriste za utvrđivanje oštećenja na DNK molekulu, određivanje mesta specifičnog vezivanja leka, redosleda vezivanja, kao i za detekciju konformacionih promena nastalih usled lek-DNK interakcije.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Drug - DNA interactions: Properties and detection
T1  - Interakcije lekova i DNK- osobine i detekcija
VL  - 63
IS  - 3
SP  - 279
EP  - 292
UR  - https://hdl.handle.net/21.15107/rcub_farfar_2017
ER  - 

@article{
author = "Aleksić, Mara and Kapetanović, Vera",
year = "2013",
abstract = "Large number of inorganic and organic compounds is able to bind to DNA and form the complex. Among them, very important drugs are chemotherapeutics. This paper presents the overview of DNA structural characteristics and types of interactions (covalent and noncovalent) between drugs and DNA molecule. Covalent binding of the drug is irreversible and leads to complete inhibition of DNA function, what conclusively, causes the cell death. On the other hand, noncovalent binding is reversible and based on the principle of molecular recognition. Special attention is paid to explain the specific sites in DNA molecule for drug binding. According to their structural characteristics, drugs that react noncovalently with DNA are intercalators, minor or major groove binders. When the complex between drug and DNA is formed, both the drug molecule, as well as DNA, experienced some modifications. This paper presents the overview of the methods used for the investigation of the interactions between drug and DNA with the aim of detection and explanation of the resulting changes. For this purpose many spectroscopic methods like UV/VIS, infrared and NMR, polarized light spectroscopies like circular and linear dichroism, fluorescence anisotropy or resonance, or very sensitive DNA-biosensors are used. The presented results summarize literature data obtained by the use of mentioned methods. The results are used to confirm the DNA damage, to determine drug binding sites and sequence preference, as well as conformational changes due to drug-DNA interaction., Komplekse sa dezoksiribonukleinskom kiselinom (DNK) gradi veliki broj neorganskih i organskih jedinjenja, među kojima su od posebnog značaja lekovi iz grupe hemioterapeutika. U radu je dat pregled strukturnih karakteristika DNK molekula i tipova interakcije (kovalentne i nekovalentne) koje se javljaju između molekula leka i DNK. Kovalentno vezivanje leka za DNK je ireverzibilno i vodi ka kompletnoj inhibiciji funkcija DNK što dovodi do smrti ćelije, dok je nekovalentno vezivanje reverzibilno i zasniva se na principu molekularnog prepoznavanja. Posebna pažnja je posvećena objašnjenju specifičnih mesta u molekulu DNK Na kojima dolazi do vezivanja leka, u zavisnosti od strukturnih karakteristika molekula leka. Najveći broj lekova koji reaguju nekovalentno su interkalatni agensi, a pored njih postoje i lekovi koji se vezuju za mali ili veliki žljeb molekula DNK. Prilikom građenja ovih kompleksa nastaju promene kako na molekulu DNK tako i na molekulu leka. U radu je dat pregled metoda koje se koriste u ispitivanju interakcija između leka i DNK sa ciljem detekcije i objašnjenja nastalih promena. U ovu svrhu koriste se spektroskopske metode, kao što su UV/VIS, infracrvena, ramanska i NMR spektroskopija, zatim spektroskopije polarizovane svetlosti: metode linearnog i cirkularnog dihroizma, fluorescentne anizotropije ili rezonancije, a u novije vreme i osetljivi DNK-biosenzori. Predstavljeni su literaturni rezultati dobijeni primenom navedenih metoda koji se koriste za utvrđivanje oštećenja na DNK molekulu, određivanje mesta specifičnog vezivanja leka, redosleda vezivanja, kao i za detekciju konformacionih promena nastalih usled lek-DNK interakcije.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Drug - DNA interactions: Properties and detection, Interakcije lekova i DNK- osobine i detekcija",
volume = "63",
number = "3",
pages = "279-292",
url = "https://hdl.handle.net/21.15107/rcub_farfar_2017"
}

Aleksić, M.,& Kapetanović, V.. (2013). Drug - DNA interactions: Properties and detection. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 63(3), 279-292.
https://hdl.handle.net/21.15107/rcub_farfar_2017

Aleksić M, Kapetanović V. Drug - DNA interactions: Properties and detection. in Arhiv za farmaciju. 2013;63(3):279-292.
https://hdl.handle.net/21.15107/rcub_farfar_2017 .

Aleksić, Mara, Kapetanović, Vera, "Drug - DNA interactions: Properties and detection" in Arhiv za farmaciju, 63, no. 3 (2013):279-292,
https://hdl.handle.net/21.15107/rcub_farfar_2017 .

TY  - JOUR
AU  - Aleksić, Mara
AU  - Lijeskić, Nikola
AU  - Pantić, Jelena
AU  - Kapetanović, Vera
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2009
AB  - The voltammetric behavior of three cephalosporins: ceftazidime, cefuroxime-axetil and ceftriaxone has been examined in pH range 2.0-8.0 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV), using a hanging mercury drop electrode (HMDE). The effect of pH of the electrolyte solution and scan rate on the peak currents and peak potentials was examined. The nature of the electrode reduction process in acid solution was found to be diffusion controlled for ceftazidime and cefuroxime-axetil, but strongly influenced by adsorption in the case of ceftriaxone reduction. The adsorption and reorientation of the ceftriaxone molecule at the electrode surface caused instability of the voltammetric signal and disabled its determination in the acid medium. Ceftriaxone adsorption decreased with the increase of pH, and at pH>7 the reduction process became diffusion controlled. Based on this study, DPV method was developed, validated and suggested for determination of ceftazidime at pH 2.0, cefuroxime-axetil at pH 3.5 and for ceftriaxone at pH 8.0. Linear concentration ranges, limits of detection (LOD) and quantification (LOQ) were determined. The method was applied for determination of cephalosporins in pharmaceutical dosage forms: Ceftazidime powder, Ceroxim tablets and Longaceph powder for injection solution.
AB  - Voltametrijsko ponašanje tri cephalosporina: ceftazidima, cefuroksim-aksetila i ceftriaksona ispitivano je cikličnom (CV) i diferencijalno pulsnom (DPV) voltametrijom u pH oblasti od 2,0 do 8,0 na visećoj živnoj kapi. Razmatrani su uticaji pH osnovnog elektrolita i brzine promene potencijala na vrednost stuje i potencijala voltametrijskih pikova. Rezultati dobijeni u kiseloj sredini su pokazali da je redukcija ceftazidima i cefuroksim-aksetila difuziono kontrolisan proces, a da je u slučaju ceftriaksona priroda redukcije na elektrodi jako zavisna od adsorpcije. Posledica adsorpcije i reorijentacije molekula ceftriaksona na površini elektrode je nestabilnost i nereproduktivnost voltametrijskog signala što onemogućava određivanje cefriaksona u kiseloj sredini. Intenzitet adsorpcije ceftriaksona opada sa porastom pH i pri pH>7 njegova redukcija postaje difuzijom kontrolisan proces. Na osnovu ovih rezultata predložena je i validirana DPV metoda za određvanje ceftazidima na pH 2,0, cefuroksim-aksetila na pH 3,5 i ceftriaksona na pH 8,0. Određene su vrednosti opsega linearnosti, granice detekcije i određivanja. Metoda je uspešno primenjena za određivanje ovih cefalosporina u farmaceutskim doziranim oblicima i to u Ceroxim tabletama i Ceftazidim i Longaceph prašku za injekcione rastvore.
PB  - Univerzitet u Nišu, Niš
T2  - Facta universitatis - series: Physics, Chemistry and Technology
T1  - Electrochemical behavior and differential pulse voltammetric determination of ceftazidime, cefuroxime-axetil and ceftriaxone
T1  - Elektrohemijsko ponašanje i primena diferencijalno pulsne voltametrije za određivanje ceftazidima, cefuroksim-aksetila i ceftriaksona
VL  - 11
IS  - 1
SP  - 55
EP  - 66
DO  - 10.2298/FUPCT1301055A
ER  - 

@article{
author = "Aleksić, Mara and Lijeskić, Nikola and Pantić, Jelena and Kapetanović, Vera",
year = "2013",
abstract = "The voltammetric behavior of three cephalosporins: ceftazidime, cefuroxime-axetil and ceftriaxone has been examined in pH range 2.0-8.0 by cyclic voltammetry (CV) and differential pulse voltammetry (DPV), using a hanging mercury drop electrode (HMDE). The effect of pH of the electrolyte solution and scan rate on the peak currents and peak potentials was examined. The nature of the electrode reduction process in acid solution was found to be diffusion controlled for ceftazidime and cefuroxime-axetil, but strongly influenced by adsorption in the case of ceftriaxone reduction. The adsorption and reorientation of the ceftriaxone molecule at the electrode surface caused instability of the voltammetric signal and disabled its determination in the acid medium. Ceftriaxone adsorption decreased with the increase of pH, and at pH>7 the reduction process became diffusion controlled. Based on this study, DPV method was developed, validated and suggested for determination of ceftazidime at pH 2.0, cefuroxime-axetil at pH 3.5 and for ceftriaxone at pH 8.0. Linear concentration ranges, limits of detection (LOD) and quantification (LOQ) were determined. The method was applied for determination of cephalosporins in pharmaceutical dosage forms: Ceftazidime powder, Ceroxim tablets and Longaceph powder for injection solution., Voltametrijsko ponašanje tri cephalosporina: ceftazidima, cefuroksim-aksetila i ceftriaksona ispitivano je cikličnom (CV) i diferencijalno pulsnom (DPV) voltametrijom u pH oblasti od 2,0 do 8,0 na visećoj živnoj kapi. Razmatrani su uticaji pH osnovnog elektrolita i brzine promene potencijala na vrednost stuje i potencijala voltametrijskih pikova. Rezultati dobijeni u kiseloj sredini su pokazali da je redukcija ceftazidima i cefuroksim-aksetila difuziono kontrolisan proces, a da je u slučaju ceftriaksona priroda redukcije na elektrodi jako zavisna od adsorpcije. Posledica adsorpcije i reorijentacije molekula ceftriaksona na površini elektrode je nestabilnost i nereproduktivnost voltametrijskog signala što onemogućava određivanje cefriaksona u kiseloj sredini. Intenzitet adsorpcije ceftriaksona opada sa porastom pH i pri pH>7 njegova redukcija postaje difuzijom kontrolisan proces. Na osnovu ovih rezultata predložena je i validirana DPV metoda za određvanje ceftazidima na pH 2,0, cefuroksim-aksetila na pH 3,5 i ceftriaksona na pH 8,0. Određene su vrednosti opsega linearnosti, granice detekcije i određivanja. Metoda je uspešno primenjena za određivanje ovih cefalosporina u farmaceutskim doziranim oblicima i to u Ceroxim tabletama i Ceftazidim i Longaceph prašku za injekcione rastvore.",
publisher = "Univerzitet u Nišu, Niš",
journal = "Facta universitatis - series: Physics, Chemistry and Technology",
title = "Electrochemical behavior and differential pulse voltammetric determination of ceftazidime, cefuroxime-axetil and ceftriaxone, Elektrohemijsko ponašanje i primena diferencijalno pulsne voltametrije za određivanje ceftazidima, cefuroksim-aksetila i ceftriaksona",
volume = "11",
number = "1",
pages = "55-66",
doi = "10.2298/FUPCT1301055A"
}

Aleksić, M., Lijeskić, N., Pantić, J.,& Kapetanović, V.. (2013). Electrochemical behavior and differential pulse voltammetric determination of ceftazidime, cefuroxime-axetil and ceftriaxone. in Facta universitatis - series: Physics, Chemistry and Technology
Univerzitet u Nišu, Niš., 11(1), 55-66.
https://doi.org/10.2298/FUPCT1301055A

Aleksić M, Lijeskić N, Pantić J, Kapetanović V. Electrochemical behavior and differential pulse voltammetric determination of ceftazidime, cefuroxime-axetil and ceftriaxone. in Facta universitatis - series: Physics, Chemistry and Technology. 2013;11(1):55-66.
doi:10.2298/FUPCT1301055A .

Aleksić, Mara, Lijeskić, Nikola, Pantić, Jelena, Kapetanović, Vera, "Electrochemical behavior and differential pulse voltammetric determination of ceftazidime, cefuroxime-axetil and ceftriaxone" in Facta universitatis - series: Physics, Chemistry and Technology, 11, no. 1 (2013):55-66,
https://doi.org/10.2298/FUPCT1301055A . .

TY  - JOUR
AU  - Aleksić, Mara
AU  - Kapetanović, Vera
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2007
AB  - In recent years, a great progress was achieved in the development of electrochemical sensors for DNA sequences, hybridization and damage. Nowadays, electrochemical methods are able to detect DNA at nanomolar concentration. In addition, these methods are suitable for studding both covalent and non-covalent binding interactions between DNA and different small molecules, e.g. drugs or potentially mutagenic agents. This suggests that electrochemical biosensors might become important tools in medical research. The aim of this review is to draw attention to the applicability of different electrochemical techniques for studying interactions between DNA with other molecules, and in the design of new sensitive and selective biosensors.
AB  - Poslednjih godina je postignut veliki napredak u razvoju elektrohemijskih biosenzora za ispitivanja sekvenci, hibridizacije i oštećenja na molekulu DNK. Primenom elektrohemijskih metoda se u današnje vreme mogu detektovati i određivati nanomolarne koncentracije DNK. Pored toga, ove metode su pogodne za ispitivanje kako kovalentnih, tako i nekovalentnih interakcija između DNK i različitih malih molekula, kakvi su lekovi i drugi potencijalno mutageni agensi. Ovo sugeriše da bi elektrohemijski biosenzori mogli biti od značaja i u oblast medicinskih istraživanja. Cilj ovoga preglednog rada je da skrene pažnju na primenljivost različitih elektrohemijskih metoda za proučavanje interakcija između DNK i drugih molekula, kao i u izradu novih osetljivih i selektivnih biosenzora.
PB  - Univerzitet u Nišu, Niš
T2  - Facta universitatis - series: Physics, Chemistry and Technology
T1  - Electrochemical biosensors as a tool for the investigation of DNA structure, damage and interaction with other molecules
T1  - Primena elektrohemijskih biosenzora za ispitivanje strukture, oštećenja i interakcija DNK sa drugim molekulima
VL  - 11
IS  - 1
SP  - 27
EP  - 43
DO  - 10.2298/FUPCT1301027A
ER  - 

@article{
author = "Aleksić, Mara and Kapetanović, Vera",
year = "2013",
abstract = "In recent years, a great progress was achieved in the development of electrochemical sensors for DNA sequences, hybridization and damage. Nowadays, electrochemical methods are able to detect DNA at nanomolar concentration. In addition, these methods are suitable for studding both covalent and non-covalent binding interactions between DNA and different small molecules, e.g. drugs or potentially mutagenic agents. This suggests that electrochemical biosensors might become important tools in medical research. The aim of this review is to draw attention to the applicability of different electrochemical techniques for studying interactions between DNA with other molecules, and in the design of new sensitive and selective biosensors., Poslednjih godina je postignut veliki napredak u razvoju elektrohemijskih biosenzora za ispitivanja sekvenci, hibridizacije i oštećenja na molekulu DNK. Primenom elektrohemijskih metoda se u današnje vreme mogu detektovati i određivati nanomolarne koncentracije DNK. Pored toga, ove metode su pogodne za ispitivanje kako kovalentnih, tako i nekovalentnih interakcija između DNK i različitih malih molekula, kakvi su lekovi i drugi potencijalno mutageni agensi. Ovo sugeriše da bi elektrohemijski biosenzori mogli biti od značaja i u oblast medicinskih istraživanja. Cilj ovoga preglednog rada je da skrene pažnju na primenljivost različitih elektrohemijskih metoda za proučavanje interakcija između DNK i drugih molekula, kao i u izradu novih osetljivih i selektivnih biosenzora.",
publisher = "Univerzitet u Nišu, Niš",
journal = "Facta universitatis - series: Physics, Chemistry and Technology",
title = "Electrochemical biosensors as a tool for the investigation of DNA structure, damage and interaction with other molecules, Primena elektrohemijskih biosenzora za ispitivanje strukture, oštećenja i interakcija DNK sa drugim molekulima",
volume = "11",
number = "1",
pages = "27-43",
doi = "10.2298/FUPCT1301027A"
}

Aleksić, M.,& Kapetanović, V.. (2013). Electrochemical biosensors as a tool for the investigation of DNA structure, damage and interaction with other molecules. in Facta universitatis - series: Physics, Chemistry and Technology
Univerzitet u Nišu, Niš., 11(1), 27-43.
https://doi.org/10.2298/FUPCT1301027A

Aleksić M, Kapetanović V. Electrochemical biosensors as a tool for the investigation of DNA structure, damage and interaction with other molecules. in Facta universitatis - series: Physics, Chemistry and Technology. 2013;11(1):27-43.
doi:10.2298/FUPCT1301027A .

Aleksić, Mara, Kapetanović, Vera, "Electrochemical biosensors as a tool for the investigation of DNA structure, damage and interaction with other molecules" in Facta universitatis - series: Physics, Chemistry and Technology, 11, no. 1 (2013):27-43,
https://doi.org/10.2298/FUPCT1301027A . .

TY  - JOUR
AU  - Aleksić, Mara
AU  - Radulović, Valentina
AU  - Agbaba, Danica
AU  - Kapetanović, Vera
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1979
AB  - The electrochemical behavior of brimonidine (BRIM), an antiglaucoma agent applied in therapy for lowering high intraocular pressure, was investigated by cyclic voltammetry, differential pulse voltammetry and square wave voltammetry using a glassy carbon electrode (GCE). The reduction of BRIM occurs as one-step quasi-reversible reaction in acid and neutral medium, reaching the full reversibility in alkaline solutions. Reduction process involves the transfer of two electrons and two protons at the pyrazine ring of quinoxaline moiety, forming a dihydro-derivative. In acid and neutral solutions, brimonidine reduction product is partly oxidized to its hydroxy-derivative. BRIM is also oxidized irreversibly with the transfer of one electron and one proton at secondary amine moiety. The effects of pH of the electrolyte solution, scan rate and BRIM concentration were monitored. The nature of the electrode process was found to be controlled by the adsorption at pH > 6 and the total surface concentration of brimonidine adsorbed onto the GCE surface at pH 7, Gamma(BRIM) = 1.35 x 10(-10) mol cm(-2) was obtained. Based on this study, differential pulse voltammetric method was developed, validated and suggested for rapid electroanalytical determination of the low concentration of brimonidine. The linearity was achieved within the concentration range from 5 x 10(-7) to 5 x 10(-6) M with LOD = 1.6 x 10(-7) M and LOQ = 5.3 x 10(-7) M. The method was applied for brimonidine determination in pharmaceutical dosage form, eye drops.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Electrochimica Acta
T1  - An extensive study of electrochemical behavior of brimonidine and its determination at glassy carbon electrode
VL  - 106
SP  - 75
EP  - 81
DO  - 10.1016/j.electacta.2013.05.053
ER  - 

@article{
author = "Aleksić, Mara and Radulović, Valentina and Agbaba, Danica and Kapetanović, Vera",
year = "2013",
abstract = "The electrochemical behavior of brimonidine (BRIM), an antiglaucoma agent applied in therapy for lowering high intraocular pressure, was investigated by cyclic voltammetry, differential pulse voltammetry and square wave voltammetry using a glassy carbon electrode (GCE). The reduction of BRIM occurs as one-step quasi-reversible reaction in acid and neutral medium, reaching the full reversibility in alkaline solutions. Reduction process involves the transfer of two electrons and two protons at the pyrazine ring of quinoxaline moiety, forming a dihydro-derivative. In acid and neutral solutions, brimonidine reduction product is partly oxidized to its hydroxy-derivative. BRIM is also oxidized irreversibly with the transfer of one electron and one proton at secondary amine moiety. The effects of pH of the electrolyte solution, scan rate and BRIM concentration were monitored. The nature of the electrode process was found to be controlled by the adsorption at pH > 6 and the total surface concentration of brimonidine adsorbed onto the GCE surface at pH 7, Gamma(BRIM) = 1.35 x 10(-10) mol cm(-2) was obtained. Based on this study, differential pulse voltammetric method was developed, validated and suggested for rapid electroanalytical determination of the low concentration of brimonidine. The linearity was achieved within the concentration range from 5 x 10(-7) to 5 x 10(-6) M with LOD = 1.6 x 10(-7) M and LOQ = 5.3 x 10(-7) M. The method was applied for brimonidine determination in pharmaceutical dosage form, eye drops.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Electrochimica Acta",
title = "An extensive study of electrochemical behavior of brimonidine and its determination at glassy carbon electrode",
volume = "106",
pages = "75-81",
doi = "10.1016/j.electacta.2013.05.053"
}

Aleksić, M., Radulović, V., Agbaba, D.,& Kapetanović, V.. (2013). An extensive study of electrochemical behavior of brimonidine and its determination at glassy carbon electrode. in Electrochimica Acta
Pergamon-Elsevier Science Ltd, Oxford., 106, 75-81.
https://doi.org/10.1016/j.electacta.2013.05.053

Aleksić M, Radulović V, Agbaba D, Kapetanović V. An extensive study of electrochemical behavior of brimonidine and its determination at glassy carbon electrode. in Electrochimica Acta. 2013;106:75-81.
doi:10.1016/j.electacta.2013.05.053 .

Aleksić, Mara, Radulović, Valentina, Agbaba, Danica, Kapetanović, Vera, "An extensive study of electrochemical behavior of brimonidine and its determination at glassy carbon electrode" in Electrochimica Acta, 106 (2013):75-81,
https://doi.org/10.1016/j.electacta.2013.05.053 . .

TY  - JOUR
AU  - Radulović, Valentina
AU  - Aleksić, Mara
AU  - Agbaba, Danica
AU  - Kapetanović, Vera
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1951
AB  - An extensive electrochemical study of brimonidine at boron doped diamond electrode (BDDE) was done by applying cyclic voltammetry (CV) and square-wave voltammetry (SWV) in sulfuric acid of different concentrations (pH ranged from 0.6 to 1.6), and in BR buffer (pH ranged from 2.0 to 9.0). It was found that the reduction of brimonidine occurred in a one-step quasi-reversible mechanism, involving the transfer of two electrons and two protons. The reduction process took place at the quinoxaline ring and the corresponding mechanism of reduction was confirmed to be the same as for the other quinoxaline derivatives. The nature of the electrode process was found to be diffusion controlled in acid medium, while in a more alkaline medium a certain degree of adsorption was noticed. Based on this study, two sensitive voltammetric methods, differential pulse (DPV) and square wave (SWV) were developed, fully validated and suggested for rapid electroanalytical determination of low concentrations of brimonidine. The linearity was achieved within the concentration range from 2x10-6 M to 3x10-5 M for DPV (LOD=6.31x10-7 M, LOQ=2.1x10-6 M) and from 5x10-7 M to 1.5x10-5 M for SWV (LOD=1.28x10-7 M, LOQ=4.28x10-7 M). The methods were applied for brimonidine determination in pharmaceutical dosage form, eye drops. The obtained good recoveries suggested these simple and accurate methods for quality control of brimonidine in dosage form. Due to its high sensitivity, the SWV method could be a good alternative for determination of low concentrations of brimonidine, even in biological samples.
PB  - Wiley-VCH Verlag GMBH, Weinheim
T2  - Electroanalysis
T1  - An Electroanalytical Approach to Brimonidine at Boron Doped Diamond Electrode Based on Its Extensive Voltammetric Study
VL  - 25
IS  - 1
SP  - 230
EP  - 236
DO  - 10.1002/elan.201200400
ER  - 

@article{
author = "Radulović, Valentina and Aleksić, Mara and Agbaba, Danica and Kapetanović, Vera",
year = "2013",
abstract = "An extensive electrochemical study of brimonidine at boron doped diamond electrode (BDDE) was done by applying cyclic voltammetry (CV) and square-wave voltammetry (SWV) in sulfuric acid of different concentrations (pH ranged from 0.6 to 1.6), and in BR buffer (pH ranged from 2.0 to 9.0). It was found that the reduction of brimonidine occurred in a one-step quasi-reversible mechanism, involving the transfer of two electrons and two protons. The reduction process took place at the quinoxaline ring and the corresponding mechanism of reduction was confirmed to be the same as for the other quinoxaline derivatives. The nature of the electrode process was found to be diffusion controlled in acid medium, while in a more alkaline medium a certain degree of adsorption was noticed. Based on this study, two sensitive voltammetric methods, differential pulse (DPV) and square wave (SWV) were developed, fully validated and suggested for rapid electroanalytical determination of low concentrations of brimonidine. The linearity was achieved within the concentration range from 2x10-6 M to 3x10-5 M for DPV (LOD=6.31x10-7 M, LOQ=2.1x10-6 M) and from 5x10-7 M to 1.5x10-5 M for SWV (LOD=1.28x10-7 M, LOQ=4.28x10-7 M). The methods were applied for brimonidine determination in pharmaceutical dosage form, eye drops. The obtained good recoveries suggested these simple and accurate methods for quality control of brimonidine in dosage form. Due to its high sensitivity, the SWV method could be a good alternative for determination of low concentrations of brimonidine, even in biological samples.",
publisher = "Wiley-VCH Verlag GMBH, Weinheim",
journal = "Electroanalysis",
title = "An Electroanalytical Approach to Brimonidine at Boron Doped Diamond Electrode Based on Its Extensive Voltammetric Study",
volume = "25",
number = "1",
pages = "230-236",
doi = "10.1002/elan.201200400"
}

Radulović, V., Aleksić, M., Agbaba, D.,& Kapetanović, V.. (2013). An Electroanalytical Approach to Brimonidine at Boron Doped Diamond Electrode Based on Its Extensive Voltammetric Study. in Electroanalysis
Wiley-VCH Verlag GMBH, Weinheim., 25(1), 230-236.
https://doi.org/10.1002/elan.201200400

Radulović V, Aleksić M, Agbaba D, Kapetanović V. An Electroanalytical Approach to Brimonidine at Boron Doped Diamond Electrode Based on Its Extensive Voltammetric Study. in Electroanalysis. 2013;25(1):230-236.
doi:10.1002/elan.201200400 .

Radulović, Valentina, Aleksić, Mara, Agbaba, Danica, Kapetanović, Vera, "An Electroanalytical Approach to Brimonidine at Boron Doped Diamond Electrode Based on Its Extensive Voltammetric Study" in Electroanalysis, 25, no. 1 (2013):230-236,
https://doi.org/10.1002/elan.201200400 . .

TY  - JOUR
AU  - Radulović, Valentina
AU  - Aleksić, Mara
AU  - Kapetanović, Vera
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1817
AB  - The electrochemical behaviour of a novel nicotinic α4β2 subtype receptor partial agonist varenicline (VAR), which is used for smoking cessation, was investigated in Britton-Robinson buffers (pH 2.0-12.0) by cyclic, differential pulse and square wave voltammetry at a hanging mercury drop electrode (HMDE). The influence of pH, scan rate, concentration, accumulation potential and time on the peak current and potential suggested that the redox process was adsorption controlled in alkaline media. In addition, the experimental value of the surface coverage, G = 1.03×10-10 mol cm-2, was used to determine the conditions when VAR was fully adsorbed at the electrode surface. Bearing in mind the potential high toxicity of VAR due to the presence of a quinoxaline structure, its interaction with double stranded-DNA (ds-DNA) was postulated and studied when both compounds were in the adsorbed state at a modified HMDE. Using the adsorptive transfer technique, changes in potential and decreases in the normalized peak currents were observed. The estimated value of the ratio of surface-binding constants indicated that the reduced form of VAR interacted with ds-DNA more strongly than the oxidized form. Subtle DNA damage under conditions of direct DNA-VAR interaction at room temperature was observed. The proposed type of interaction was intercalation. This study employed a simple electroanalytical methodology and showed the potential of a DNA/ /HMDE biosensor for investigation of genotoxic effects.
AB  - Elektrohemijsko ponašanje vareniklina, novog parcijalnog agoniste α4β2 nikotinskog receptora, koji se koristi za odvikavanje od pušenja, ispitano je cikličnom, diferencijalno pulsnom i voltametrijom pravougaonih talasa u Briton-Robinsonovom puferu (pH 2,0-12,0). Na osnovu uticaja pH, brzine promene potencijala, koncentracije, potencijala i vremena akumulacije na visinu i položaj pika, zaključeno je da je proces redukcije u alkalnoj sredini kontrolisan adsorpcijom vareniklina. Korišćenjem eksperimentalno dobijene vrednosti površinske zaposednutosti, G = 1,03×10-10 mol cm-2, određeni su uslovi pod kojima je vareniklin potpuno adsorbovan na površini elektrode. Imajući u vidu moguću visoku toksičnost vareniklina, s obzirom na prisustvo hinoksalinskog prstena u strukturi, pretpostavljeno je da vareniklin interaguje sa DNK kada su oba molekula adsorbovana na modifikovanoj živinoj elektrodi. Ova interakcija je ispitana korišćenjem 'adsorptivne transfer tehnike' i primećene su promene potencijala i smanjenje normalizovanih struja voltametrijskih pikova. Na osnovu izračunate vrednosti odnosa konstanti vezivanja zaključeno je da se redukovani oblik vareniklina jače vezuje za DNK od oksidovanog. Pretpostavljeno je da direktna vareniklin-DNK interakcija na sobnoj temperaturi dovodi do izvesnog oštećenja DNK i da je tip interakcije - interkalacija. Ova jednostavna elektroanalitička metodologija mogla bi naći primenu u vidu potencijalnog biosenzora za ispitivanje genotoksičnih efekata.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - An electrochemical study of the adsorptive behaviour of varenicline and its interaction with DNA
T1  - Elektrohemijsko ispitivanje adsorpcije i interakcije vareniklina i DNK
VL  - 77
IS  - 10
SP  - 1409
EP  - 1422
DO  - 10.2298/JSC120420073R
ER  - 

@article{
author = "Radulović, Valentina and Aleksić, Mara and Kapetanović, Vera",
year = "2012",
abstract = "The electrochemical behaviour of a novel nicotinic α4β2 subtype receptor partial agonist varenicline (VAR), which is used for smoking cessation, was investigated in Britton-Robinson buffers (pH 2.0-12.0) by cyclic, differential pulse and square wave voltammetry at a hanging mercury drop electrode (HMDE). The influence of pH, scan rate, concentration, accumulation potential and time on the peak current and potential suggested that the redox process was adsorption controlled in alkaline media. In addition, the experimental value of the surface coverage, G = 1.03×10-10 mol cm-2, was used to determine the conditions when VAR was fully adsorbed at the electrode surface. Bearing in mind the potential high toxicity of VAR due to the presence of a quinoxaline structure, its interaction with double stranded-DNA (ds-DNA) was postulated and studied when both compounds were in the adsorbed state at a modified HMDE. Using the adsorptive transfer technique, changes in potential and decreases in the normalized peak currents were observed. The estimated value of the ratio of surface-binding constants indicated that the reduced form of VAR interacted with ds-DNA more strongly than the oxidized form. Subtle DNA damage under conditions of direct DNA-VAR interaction at room temperature was observed. The proposed type of interaction was intercalation. This study employed a simple electroanalytical methodology and showed the potential of a DNA/ /HMDE biosensor for investigation of genotoxic effects., Elektrohemijsko ponašanje vareniklina, novog parcijalnog agoniste α4β2 nikotinskog receptora, koji se koristi za odvikavanje od pušenja, ispitano je cikličnom, diferencijalno pulsnom i voltametrijom pravougaonih talasa u Briton-Robinsonovom puferu (pH 2,0-12,0). Na osnovu uticaja pH, brzine promene potencijala, koncentracije, potencijala i vremena akumulacije na visinu i položaj pika, zaključeno je da je proces redukcije u alkalnoj sredini kontrolisan adsorpcijom vareniklina. Korišćenjem eksperimentalno dobijene vrednosti površinske zaposednutosti, G = 1,03×10-10 mol cm-2, određeni su uslovi pod kojima je vareniklin potpuno adsorbovan na površini elektrode. Imajući u vidu moguću visoku toksičnost vareniklina, s obzirom na prisustvo hinoksalinskog prstena u strukturi, pretpostavljeno je da vareniklin interaguje sa DNK kada su oba molekula adsorbovana na modifikovanoj živinoj elektrodi. Ova interakcija je ispitana korišćenjem 'adsorptivne transfer tehnike' i primećene su promene potencijala i smanjenje normalizovanih struja voltametrijskih pikova. Na osnovu izračunate vrednosti odnosa konstanti vezivanja zaključeno je da se redukovani oblik vareniklina jače vezuje za DNK od oksidovanog. Pretpostavljeno je da direktna vareniklin-DNK interakcija na sobnoj temperaturi dovodi do izvesnog oštećenja DNK i da je tip interakcije - interkalacija. Ova jednostavna elektroanalitička metodologija mogla bi naći primenu u vidu potencijalnog biosenzora za ispitivanje genotoksičnih efekata.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "An electrochemical study of the adsorptive behaviour of varenicline and its interaction with DNA, Elektrohemijsko ispitivanje adsorpcije i interakcije vareniklina i DNK",
volume = "77",
number = "10",
pages = "1409-1422",
doi = "10.2298/JSC120420073R"
}

Radulović, V., Aleksić, M.,& Kapetanović, V.. (2012). An electrochemical study of the adsorptive behaviour of varenicline and its interaction with DNA. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 77(10), 1409-1422.
https://doi.org/10.2298/JSC120420073R

Radulović V, Aleksić M, Kapetanović V. An electrochemical study of the adsorptive behaviour of varenicline and its interaction with DNA. in Journal of the Serbian Chemical Society. 2012;77(10):1409-1422.
doi:10.2298/JSC120420073R .

Radulović, Valentina, Aleksić, Mara, Kapetanović, Vera, "An electrochemical study of the adsorptive behaviour of varenicline and its interaction with DNA" in Journal of the Serbian Chemical Society, 77, no. 10 (2012):1409-1422,
https://doi.org/10.2298/JSC120420073R . .

TY  - JOUR
AU  - Aleksić, Mara
AU  - Radulović, Valentina
AU  - Lijeskić, Nikola
AU  - Kapetanović, Vera
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1739
AB  - The electrochemical study of varenicline (VAR) was done in a wide pH range (2-12), at boron doped diamond electrode (BDDE), glassy carbon electrode (GCE) and hanging mercury electrode (HMDE), using cyclic (CV), square wave (SW) and adsorptive stripping square wave (AdSSW) voltammetric techniques. Depending on the pH and the type of the working electrode the characteristic electrochemical behavior of varenicline was established. The mechanism of the reduction process was suggested. Based on the obtained results, the new electroanalytical method was developed for its determination in the buffer solutions and plasma samples. By applying a square wave voltammetry (SWV) on BDDE and GCE, at pH 3.5 and 4.0, the linear dependence in plasma samples was achieved within the concentration range from 2 10(-6) -1 x 10(-5) M and 4 x 10(-6) -1 x 10(-5) M, respectively. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 7.1 x 10(-7) M and 2.4 x 10(-6) M on BDDE, and 1.0 x 10(-6) M and 3.5 x 10(-6) M on GCE, respectively. The recovery and RSD values obtained for VAR in plasma suggested BDDE electrode to be preferable in comparison with GCE. The accuracy of the voltammetric method was confirmed by the determination of VAR in plasma spiked with Champix (R) tablets and the results were statistically compared with those obtained with Ultra Performance Liquid Chromatography (UPLC) method, as a reference one.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Analytical Chemistry
T1  - Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes
VL  - 8
IS  - 1
SP  - 133
EP  - 142
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1739
ER  - 

@article{
author = "Aleksić, Mara and Radulović, Valentina and Lijeskić, Nikola and Kapetanović, Vera",
year = "2012",
abstract = "The electrochemical study of varenicline (VAR) was done in a wide pH range (2-12), at boron doped diamond electrode (BDDE), glassy carbon electrode (GCE) and hanging mercury electrode (HMDE), using cyclic (CV), square wave (SW) and adsorptive stripping square wave (AdSSW) voltammetric techniques. Depending on the pH and the type of the working electrode the characteristic electrochemical behavior of varenicline was established. The mechanism of the reduction process was suggested. Based on the obtained results, the new electroanalytical method was developed for its determination in the buffer solutions and plasma samples. By applying a square wave voltammetry (SWV) on BDDE and GCE, at pH 3.5 and 4.0, the linear dependence in plasma samples was achieved within the concentration range from 2 10(-6) -1 x 10(-5) M and 4 x 10(-6) -1 x 10(-5) M, respectively. Limit of detection (LOD) and limit of quantification (LOQ) were obtained as 7.1 x 10(-7) M and 2.4 x 10(-6) M on BDDE, and 1.0 x 10(-6) M and 3.5 x 10(-6) M on GCE, respectively. The recovery and RSD values obtained for VAR in plasma suggested BDDE electrode to be preferable in comparison with GCE. The accuracy of the voltammetric method was confirmed by the determination of VAR in plasma spiked with Champix (R) tablets and the results were statistically compared with those obtained with Ultra Performance Liquid Chromatography (UPLC) method, as a reference one.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Analytical Chemistry",
title = "Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes",
volume = "8",
number = "1",
pages = "133-142",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1739"
}

Aleksić, M., Radulović, V., Lijeskić, N.,& Kapetanović, V.. (2012). Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes. in Current Analytical Chemistry
Bentham Science Publ Ltd, Sharjah., 8(1), 133-142.
https://hdl.handle.net/21.15107/rcub_farfar_1739

Aleksić M, Radulović V, Lijeskić N, Kapetanović V. Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes. in Current Analytical Chemistry. 2012;8(1):133-142.
https://hdl.handle.net/21.15107/rcub_farfar_1739 .

Aleksić, Mara, Radulović, Valentina, Lijeskić, Nikola, Kapetanović, Vera, "Electrochemical Response and Determination of Varenicline at Boron Doped Diamond, Glassy Carbon and Hanging Mercury Electrodes" in Current Analytical Chemistry, 8, no. 1 (2012):133-142,
https://hdl.handle.net/21.15107/rcub_farfar_1739 .

TY  - JOUR
AU  - Aleksić, Mara
AU  - Kapetanović, Vera
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1345
AB  - In the last two decades different electroanalytical methods were used for sensitive and selective determination of cephalosporins. The paper was focused on the electrochemical behavior of methoxyimino cephalosporins, reduction mechanism and nature of the process at the mercury electrode surface. Special attention was paid to the cephalosporins adsorption at the mercury surface. Based on this phenomenon, the adsorptive stripping methods were established for determination of the low concentration of these drugs in urine samples, both in vitro, and in vivo conditions. The application of Adsorptive Stripping Differential Pulse Voltammetry (AdSDPV) for the determination of cefpodoxime proxetil (CP), cefotaxime (CF), desacetylcefotaxime (DCF) and cefetamet (CEF) was summarized. The best sensitivity of in vitro determination in urine was achieved for CP, in acid solutions (LOD 7.4.10(-9) M and LOQ 2.4.10(-8) M), followed by CF, CEF and DCF. This is in accordance with the strength of their adsorption. Determination of CF and DCF by AdSDPV in vivo was also presented. Compared to other analytical methods, AdSDPV showed advantages in the simplicity of sample preparation, and over the other voltamperometric methods, higher sensitivity and selectivity.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Combinatorial Chemistry & High Throughput Screening
T1  - Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples
VL  - 13
IS  - 8
SP  - 758
EP  - 763
DO  - 10.2174/138620710791920310
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1345
ER  - 

@article{
author = "Aleksić, Mara and Kapetanović, Vera",
year = "2010",
abstract = "In the last two decades different electroanalytical methods were used for sensitive and selective determination of cephalosporins. The paper was focused on the electrochemical behavior of methoxyimino cephalosporins, reduction mechanism and nature of the process at the mercury electrode surface. Special attention was paid to the cephalosporins adsorption at the mercury surface. Based on this phenomenon, the adsorptive stripping methods were established for determination of the low concentration of these drugs in urine samples, both in vitro, and in vivo conditions. The application of Adsorptive Stripping Differential Pulse Voltammetry (AdSDPV) for the determination of cefpodoxime proxetil (CP), cefotaxime (CF), desacetylcefotaxime (DCF) and cefetamet (CEF) was summarized. The best sensitivity of in vitro determination in urine was achieved for CP, in acid solutions (LOD 7.4.10(-9) M and LOQ 2.4.10(-8) M), followed by CF, CEF and DCF. This is in accordance with the strength of their adsorption. Determination of CF and DCF by AdSDPV in vivo was also presented. Compared to other analytical methods, AdSDPV showed advantages in the simplicity of sample preparation, and over the other voltamperometric methods, higher sensitivity and selectivity.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Combinatorial Chemistry & High Throughput Screening",
title = "Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples",
volume = "13",
number = "8",
pages = "758-763",
doi = "10.2174/138620710791920310",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1345"
}

Aleksić, M.,& Kapetanović, V.. (2010). Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples. in Combinatorial Chemistry & High Throughput Screening
Bentham Science Publ Ltd, Sharjah., 13(8), 758-763.
https://doi.org/10.2174/138620710791920310
https://hdl.handle.net/21.15107/rcub_farfar_1345

Aleksić M, Kapetanović V. Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples. in Combinatorial Chemistry & High Throughput Screening. 2010;13(8):758-763.
doi:10.2174/138620710791920310
https://hdl.handle.net/21.15107/rcub_farfar_1345 .

Aleksić, Mara, Kapetanović, Vera, "Application of Adsorptive Stripping Voltammetry for the Determination of Selected Methoxyimino Cephalosporins in Urine Samples" in Combinatorial Chemistry & High Throughput Screening, 13, no. 8 (2010):758-763,
https://doi.org/10.2174/138620710791920310 .,
https://hdl.handle.net/21.15107/rcub_farfar_1345 .

TY  - JOUR
AU  - Živanović, Marko
AU  - Aleksić, Mara
AU  - Ostatna, Veronika
AU  - Doneux, Thomas
AU  - Paleček, Emil
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5494
AB  - Abstract
It has been shown that peptides and proteins produce at nanomolar concentrations a structure-sensitive chronopotentiometric peak H at mercury electrodes, which is due to the catalytic hydrogen evolution reaction (HER).
Herein, we use for the first time poly(amino acids) to obtain information about the role of individual amino acid
residues in the HER. At pH 6 polylysine (polyLys) and polyarginine,tryptophan yield a peak H, in agreement with
their ionization state, while polyglutamic acid gives no catalytic response. PolyLys catalyzes hydrogen evolution in
its adsorbed state. Even at potentials negative to the potential of zero charge, hydrophobic interactions could be involved in polyLys adsorption.
PB  - Wiley
T2  - Electroanalysis
T1  - Polylysine-Catalyzed Hydrogen Evolution at Mercury Electrodes
VL  - 22
IS  - 17-18
SP  - 2064
EP  - 2070
DO  - 10.1002/elan.201000088
ER  - 

@article{
author = "Živanović, Marko and Aleksić, Mara and Ostatna, Veronika and Doneux, Thomas and Paleček, Emil",
year = "2010",
abstract = "Abstract
It has been shown that peptides and proteins produce at nanomolar concentrations a structure-sensitive chronopotentiometric peak H at mercury electrodes, which is due to the catalytic hydrogen evolution reaction (HER).
Herein, we use for the first time poly(amino acids) to obtain information about the role of individual amino acid
residues in the HER. At pH 6 polylysine (polyLys) and polyarginine,tryptophan yield a peak H, in agreement with
their ionization state, while polyglutamic acid gives no catalytic response. PolyLys catalyzes hydrogen evolution in
its adsorbed state. Even at potentials negative to the potential of zero charge, hydrophobic interactions could be involved in polyLys adsorption.",
publisher = "Wiley",
journal = "Electroanalysis",
title = "Polylysine-Catalyzed Hydrogen Evolution at Mercury Electrodes",
volume = "22",
number = "17-18",
pages = "2064-2070",
doi = "10.1002/elan.201000088"
}

Živanović, M., Aleksić, M., Ostatna, V., Doneux, T.,& Paleček, E.. (2010). Polylysine-Catalyzed Hydrogen Evolution at Mercury Electrodes. in Electroanalysis
Wiley., 22(17-18), 2064-2070.
https://doi.org/10.1002/elan.201000088

Živanović M, Aleksić M, Ostatna V, Doneux T, Paleček E. Polylysine-Catalyzed Hydrogen Evolution at Mercury Electrodes. in Electroanalysis. 2010;22(17-18):2064-2070.
doi:10.1002/elan.201000088 .

Živanović, Marko, Aleksić, Mara, Ostatna, Veronika, Doneux, Thomas, Paleček, Emil, "Polylysine-Catalyzed Hydrogen Evolution at Mercury Electrodes" in Electroanalysis, 22, no. 17-18 (2010):2064-2070,
https://doi.org/10.1002/elan.201000088 . .

TY  - JOUR
AU  - Aleksić, Mara
AU  - Radulović, Valentina
AU  - Kapetanović, Vera
AU  - Savić, Vladimir
PY  - 2010
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1359
AB  - The electrochemical behaviour of desloratadine (DLOR) and its derivative 3-hydroxydesloratadine (3OH-DLOR) was investigated by direct current (DCP) polarography, cyclic (CV), differential pulse (DPV) and square-wave (SWV) voltammetry in Britton-Robinson (BR) buffer solutions (pH 4-11). Both compounds are reduced at mercury electrode in irreversible two electron reduction of the C=N bond of the pyridine ring in their molecules. The difference in their electrochemical behaviour was investigated, and the most pronounced distinction is observed at pH > 9, as a consequence of the deprotonation of the phenolic moiety in 3OH-DLOR molecule, yielding significant change in their reduction potentials (E (p DLOR) = -1.48 V, and E(p 3OH-DLOR) = -1.6 V). The observed results correlate with calculated LUMO energy levels and Hammet substituent constants (sigma). Based on the difference in the reduction potential for DLOR and 3OH-DLOR, conditions for simultaneous determination these two molecules in alkaline medium were established. The best selectivity was achieved using SWV method at pH 10. The linearity of the calibration graphs were achieved in the concentration range from 1.5 x 10(-6) M-1 x 10(-5) M for DLOR and 7.5 x 10(-6) M(-5) x 10(-5) M for 3OH-DLOR with detection limits of 2.29 x 10(-7) M and 2.08 x 10(-6) M, and determination limits of 7.64 x 10(-7) M and 6.94 x 10(-6) M, for DLOR and 3OH-DLOR, respectively. The method was checked in human plasma sample. Good response was obtained with LOD and LOQ values of 4.63 x 10(-7) M and 1.54 x 10(-6) M, for DLOR and 2.39 x 10(-6) M and 7.97 x 10(-6) M, 3OH-DLOR, respectively.
PB  - Slovensko Kemijsko Drustvo, Ljubljana
T2  - Acta Chimica Slovenica
T1  - The Possibility of Simultaneous Voltammetric Determination of Desloratadine and 3-Hydroxydesloratadine
VL  - 57
IS  - 3
SP  - 686
EP  - 692
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1359
ER  - 

@article{
author = "Aleksić, Mara and Radulović, Valentina and Kapetanović, Vera and Savić, Vladimir",
year = "2010",
abstract = "The electrochemical behaviour of desloratadine (DLOR) and its derivative 3-hydroxydesloratadine (3OH-DLOR) was investigated by direct current (DCP) polarography, cyclic (CV), differential pulse (DPV) and square-wave (SWV) voltammetry in Britton-Robinson (BR) buffer solutions (pH 4-11). Both compounds are reduced at mercury electrode in irreversible two electron reduction of the C=N bond of the pyridine ring in their molecules. The difference in their electrochemical behaviour was investigated, and the most pronounced distinction is observed at pH > 9, as a consequence of the deprotonation of the phenolic moiety in 3OH-DLOR molecule, yielding significant change in their reduction potentials (E (p DLOR) = -1.48 V, and E(p 3OH-DLOR) = -1.6 V). The observed results correlate with calculated LUMO energy levels and Hammet substituent constants (sigma). Based on the difference in the reduction potential for DLOR and 3OH-DLOR, conditions for simultaneous determination these two molecules in alkaline medium were established. The best selectivity was achieved using SWV method at pH 10. The linearity of the calibration graphs were achieved in the concentration range from 1.5 x 10(-6) M-1 x 10(-5) M for DLOR and 7.5 x 10(-6) M(-5) x 10(-5) M for 3OH-DLOR with detection limits of 2.29 x 10(-7) M and 2.08 x 10(-6) M, and determination limits of 7.64 x 10(-7) M and 6.94 x 10(-6) M, for DLOR and 3OH-DLOR, respectively. The method was checked in human plasma sample. Good response was obtained with LOD and LOQ values of 4.63 x 10(-7) M and 1.54 x 10(-6) M, for DLOR and 2.39 x 10(-6) M and 7.97 x 10(-6) M, 3OH-DLOR, respectively.",
publisher = "Slovensko Kemijsko Drustvo, Ljubljana",
journal = "Acta Chimica Slovenica",
title = "The Possibility of Simultaneous Voltammetric Determination of Desloratadine and 3-Hydroxydesloratadine",
volume = "57",
number = "3",
pages = "686-692",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1359"
}

Aleksić, M., Radulović, V., Kapetanović, V.,& Savić, V.. (2010). The Possibility of Simultaneous Voltammetric Determination of Desloratadine and 3-Hydroxydesloratadine. in Acta Chimica Slovenica
Slovensko Kemijsko Drustvo, Ljubljana., 57(3), 686-692.
https://hdl.handle.net/21.15107/rcub_farfar_1359

Aleksić M, Radulović V, Kapetanović V, Savić V. The Possibility of Simultaneous Voltammetric Determination of Desloratadine and 3-Hydroxydesloratadine. in Acta Chimica Slovenica. 2010;57(3):686-692.
https://hdl.handle.net/21.15107/rcub_farfar_1359 .

Aleksić, Mara, Radulović, Valentina, Kapetanović, Vera, Savić, Vladimir, "The Possibility of Simultaneous Voltammetric Determination of Desloratadine and 3-Hydroxydesloratadine" in Acta Chimica Slovenica, 57, no. 3 (2010):686-692,
https://hdl.handle.net/21.15107/rcub_farfar_1359 .