TY  - JOUR
AU  - Paripović, Dušan
AU  - Kotur-Stevuljević, Jelena
AU  - Vukašinović, Aleksandra
AU  - Ilisić, Tamara
AU  - Miloševski-Lomić, Gordana
AU  - Peco-Antić, Amira
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3144
AB  - Oxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. A total of 113 obese participants referred for 24-h ambulatory blood pressure monitoring (ABPM) aged 9-19 years, and 29 healthy controls were enrolled. In addition to anthropometric and biochemical measurements, such as fasting serum levels of glucose, insulin, lipid profile, and oxidative biomarkers, ABPM and echocardiography were performed.According to ABPM results, obese subjects were split in two groups: 57 hypertensive and 56 normotensive. Both hypertensive and normotensive obese participants had higher levels of oxidative stress parameters (pro-oxidative/antioxidative balance and total oxidant status) compared with control group. Levels of superoxide anion (O-2(-)) and sulfhydryl groups were higher in obese hypertensive participants as compared to obese normotensive and control groups. Abnormal left ventricular geometry among obese participants was independently associated with O-2(-) (p = .006) and body mass index z score (p = .020), with no significant impact of gender, while age and systolic blood pressure exhibited interaction term for the outcome.The independent effect of oxidative mechanisms on left ventricular geometry appears to start in childhood. Oxidative stress occurs in obese adolescents prior to the development of sustained hypertension.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Scandinavian Journal of Clinical and Laboratory Investigation
T1  - The influence of oxidative stress on cardiac remodeling in obese adolescents
VL  - 78
IS  - 7-8
SP  - 595
EP  - 600
DO  - 10.1080/00365513.2018.1528504
ER  - 

@article{
author = "Paripović, Dušan and Kotur-Stevuljević, Jelena and Vukašinović, Aleksandra and Ilisić, Tamara and Miloševski-Lomić, Gordana and Peco-Antić, Amira",
year = "2018",
abstract = "Oxidative stress seems to be an important link between obesity and cardiovascular disease. The aim of our study was to assess oxidative stress in obese patients stratified according to ambulatory blood pressure status and to determine independent predictors of abnormal left ventricular geometry.A cross-sectional study was conducted. A total of 113 obese participants referred for 24-h ambulatory blood pressure monitoring (ABPM) aged 9-19 years, and 29 healthy controls were enrolled. In addition to anthropometric and biochemical measurements, such as fasting serum levels of glucose, insulin, lipid profile, and oxidative biomarkers, ABPM and echocardiography were performed.According to ABPM results, obese subjects were split in two groups: 57 hypertensive and 56 normotensive. Both hypertensive and normotensive obese participants had higher levels of oxidative stress parameters (pro-oxidative/antioxidative balance and total oxidant status) compared with control group. Levels of superoxide anion (O-2(-)) and sulfhydryl groups were higher in obese hypertensive participants as compared to obese normotensive and control groups. Abnormal left ventricular geometry among obese participants was independently associated with O-2(-) (p = .006) and body mass index z score (p = .020), with no significant impact of gender, while age and systolic blood pressure exhibited interaction term for the outcome.The independent effect of oxidative mechanisms on left ventricular geometry appears to start in childhood. Oxidative stress occurs in obese adolescents prior to the development of sustained hypertension.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Scandinavian Journal of Clinical and Laboratory Investigation",
title = "The influence of oxidative stress on cardiac remodeling in obese adolescents",
volume = "78",
number = "7-8",
pages = "595-600",
doi = "10.1080/00365513.2018.1528504"
}

Paripović, D., Kotur-Stevuljević, J., Vukašinović, A., Ilisić, T., Miloševski-Lomić, G.,& Peco-Antić, A.. (2018). The influence of oxidative stress on cardiac remodeling in obese adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation
Taylor & Francis Ltd, Abingdon., 78(7-8), 595-600.
https://doi.org/10.1080/00365513.2018.1528504

Paripović D, Kotur-Stevuljević J, Vukašinović A, Ilisić T, Miloševski-Lomić G, Peco-Antić A. The influence of oxidative stress on cardiac remodeling in obese adolescents. in Scandinavian Journal of Clinical and Laboratory Investigation. 2018;78(7-8):595-600.
doi:10.1080/00365513.2018.1528504 .

Paripović, Dušan, Kotur-Stevuljević, Jelena, Vukašinović, Aleksandra, Ilisić, Tamara, Miloševski-Lomić, Gordana, Peco-Antić, Amira, "The influence of oxidative stress on cardiac remodeling in obese adolescents" in Scandinavian Journal of Clinical and Laboratory Investigation, 78, no. 7-8 (2018):595-600,
https://doi.org/10.1080/00365513.2018.1528504 . .