TY  - JOUR
AU  - Cekić, Nebojša
AU  - Savić, Snežana
AU  - Milić, Jela
AU  - Savić, Miroslav
AU  - Jović, Žarko
AU  - Malesević, Marjia
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/890
AB  - We aimed to prepare and investigate microparticles with the varying contents of calcium gelling ion, loaded with phenytoin, a standard antiepileptic agent, in its acidic form. Two different methods of alginate-based microparticles preparation were used: with and without treatment with chitosan. Furthermore, two standard procedures, the one-stage and the two-stage, were applied. Microparticle size of 12 one-stage formulations ranged from 466 to 636 m. Both types of formulations, chitosan-treated and nontreated, appeared to be highly loaded with the model drug ( 91-96%). The chitosan-coated alginate-based microparticles prepared by the one-stage procedure exhibited kinetics of phenytoin liberation comparable to a similar sustained release system that had been tested at pH 6.8, as published earlier. As the gel erosion of alginate-based microparticles should be potentiated by the higher pH ( used in the present study at pH 7.4), the most favorable of 12 formulations, with the liberation half-time of about 2 hr, seemed to be eligible for further modifications. Counterintuitively, the applied two-stage procedure did not appear to beneficially affect the dissolution behavior of phenytoin when tested in two formulations, which makes further modifications necessary.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Drug Delivery
T1  - Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles
VL  - 14
IS  - 8
SP  - 483
EP  - 490
DO  - 10.1080/10717540701604769
ER  - 

@article{
author = "Cekić, Nebojša and Savić, Snežana and Milić, Jela and Savić, Miroslav and Jović, Žarko and Malesević, Marjia",
year = "2007",
abstract = "We aimed to prepare and investigate microparticles with the varying contents of calcium gelling ion, loaded with phenytoin, a standard antiepileptic agent, in its acidic form. Two different methods of alginate-based microparticles preparation were used: with and without treatment with chitosan. Furthermore, two standard procedures, the one-stage and the two-stage, were applied. Microparticle size of 12 one-stage formulations ranged from 466 to 636 m. Both types of formulations, chitosan-treated and nontreated, appeared to be highly loaded with the model drug ( 91-96%). The chitosan-coated alginate-based microparticles prepared by the one-stage procedure exhibited kinetics of phenytoin liberation comparable to a similar sustained release system that had been tested at pH 6.8, as published earlier. As the gel erosion of alginate-based microparticles should be potentiated by the higher pH ( used in the present study at pH 7.4), the most favorable of 12 formulations, with the liberation half-time of about 2 hr, seemed to be eligible for further modifications. Counterintuitively, the applied two-stage procedure did not appear to beneficially affect the dissolution behavior of phenytoin when tested in two formulations, which makes further modifications necessary.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Drug Delivery",
title = "Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles",
volume = "14",
number = "8",
pages = "483-490",
doi = "10.1080/10717540701604769"
}

Cekić, N., Savić, S., Milić, J., Savić, M., Jović, Ž.,& Malesević, M.. (2007). Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles. in Drug Delivery
Taylor & Francis Inc, Philadelphia., 14(8), 483-490.
https://doi.org/10.1080/10717540701604769

Cekić N, Savić S, Milić J, Savić M, Jović Ž, Malesević M. Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles. in Drug Delivery. 2007;14(8):483-490.
doi:10.1080/10717540701604769 .

Cekić, Nebojša, Savić, Snežana, Milić, Jela, Savić, Miroslav, Jović, Žarko, Malesević, Marjia, "Preparation and characterisation of phenytoin-loaded alginate and alginate-chitosan microparticles" in Drug Delivery, 14, no. 8 (2007):483-490,
https://doi.org/10.1080/10717540701604769 . .