TY  - CONF
AU  - Đunić, Irena
AU  - Dopsaj, Violeta
AU  - Lesić, Aleksandar
AU  - Miljić, Predrag
AU  - Mihaljević, Biljana
AU  - Suvajdžić-Vuković, Nada
AU  - Tomin, Dragica
AU  - Novković, Aleksandra
AU  - Elezović, Ivo
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2229
PB  - Wiley-Blackwell, Hoboken
C3  - Haemophilia
T1  - The role of biomarkers of joint damage in monitoring the efficacy of different prophylaxis regimens for severe hemophilia
VL  - 20
IS  - Supplement 3
SP  - 64
EP  - 64
DO  - 10.1111/hae.12400
ER  - 

@conference{
author = "Đunić, Irena and Dopsaj, Violeta and Lesić, Aleksandar and Miljić, Predrag and Mihaljević, Biljana and Suvajdžić-Vuković, Nada and Tomin, Dragica and Novković, Aleksandra and Elezović, Ivo",
year = "2014",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Haemophilia",
title = "The role of biomarkers of joint damage in monitoring the efficacy of different prophylaxis regimens for severe hemophilia",
volume = "20",
number = "Supplement 3",
pages = "64-64",
doi = "10.1111/hae.12400"
}

Đunić, I., Dopsaj, V., Lesić, A., Miljić, P., Mihaljević, B., Suvajdžić-Vuković, N., Tomin, D., Novković, A.,& Elezović, I.. (2014). The role of biomarkers of joint damage in monitoring the efficacy of different prophylaxis regimens for severe hemophilia. in Haemophilia
Wiley-Blackwell, Hoboken., 20(Supplement 3), 64-64.
https://doi.org/10.1111/hae.12400

Đunić I, Dopsaj V, Lesić A, Miljić P, Mihaljević B, Suvajdžić-Vuković N, Tomin D, Novković A, Elezović I. The role of biomarkers of joint damage in monitoring the efficacy of different prophylaxis regimens for severe hemophilia. in Haemophilia. 2014;20(Supplement 3):64-64.
doi:10.1111/hae.12400 .

Đunić, Irena, Dopsaj, Violeta, Lesić, Aleksandar, Miljić, Predrag, Mihaljević, Biljana, Suvajdžić-Vuković, Nada, Tomin, Dragica, Novković, Aleksandra, Elezović, Ivo, "The role of biomarkers of joint damage in monitoring the efficacy of different prophylaxis regimens for severe hemophilia" in Haemophilia, 20, no. Supplement 3 (2014):64-64,
https://doi.org/10.1111/hae.12400 . .

TY  - JOUR
AU  - Gojković-Bukarica, Ljiljana
AU  - Novaković, Aleksandra
AU  - Kanjuh, Vladimir
AU  - Bumbasirević, Marko
AU  - Lesić, Aleksandar
AU  - Heinle, Helmut
PY  - 2008
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1041
AB  - Recently it has been suggested that resveratrol relaxes different isolated arteries. The present study addressed the question whether different ion channels are involved in the endothelium-independent mechanism of vasodilatation induced by resveratrol. For that purpose, we tested the action of resveratrol on the rat mesenteric artery without endothelium. Resveratrol induced con centration-dependent relaxation of rat mesenteric artery. Among the K+-channel blockers, 4-amynopiridine (4-AP) moderately antagonized the resveratrol-induced relaxation, while glibendamide, tetraethylammonium chloride, charybdotoxin, margatoxin, and barium chloride did not inhibit resveratrol-induced vasorelaxation. In rings, precontracted with 100 mM K+, the relaxant responses to resveratrol were highly significantly shifted to the right compared to those obtained in rings precontracted with phenylephrine, but resveratrol-induced maximal relaxation was only slightly affected. In order to minimize the influence of K+ channels and voltage-gated Ca2+ channels (VGCCs) in vascular smooth muscle, the third contraction was made by 100 in M K- in the presence of nifedipine. The relaxant response to resveratrol was abolished. Thus, the mechanism of vasorelaxation induced by resveratrol probably involves activation of 4-AP-sensitive K+ channels. Its ability to completely relax the mesenteric artery precontracted with K+-rich solution suggests that K channel-independent mechanism(s) are involved in its vasorelaxant effect. It seems that interaction with VGCCs plays a part in this K+ channel-independent effect of resveratrol.
PB  - Japanese Pharmacological Soc, Kyoto
T2  - Journal of Pharmacological Sciences
T1  - A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol
VL  - 108
IS  - 1
SP  - 124
EP  - 130
DO  - 10.1254/jphs.08128FP
ER  - 

@article{
author = "Gojković-Bukarica, Ljiljana and Novaković, Aleksandra and Kanjuh, Vladimir and Bumbasirević, Marko and Lesić, Aleksandar and Heinle, Helmut",
year = "2008",
abstract = "Recently it has been suggested that resveratrol relaxes different isolated arteries. The present study addressed the question whether different ion channels are involved in the endothelium-independent mechanism of vasodilatation induced by resveratrol. For that purpose, we tested the action of resveratrol on the rat mesenteric artery without endothelium. Resveratrol induced con centration-dependent relaxation of rat mesenteric artery. Among the K+-channel blockers, 4-amynopiridine (4-AP) moderately antagonized the resveratrol-induced relaxation, while glibendamide, tetraethylammonium chloride, charybdotoxin, margatoxin, and barium chloride did not inhibit resveratrol-induced vasorelaxation. In rings, precontracted with 100 mM K+, the relaxant responses to resveratrol were highly significantly shifted to the right compared to those obtained in rings precontracted with phenylephrine, but resveratrol-induced maximal relaxation was only slightly affected. In order to minimize the influence of K+ channels and voltage-gated Ca2+ channels (VGCCs) in vascular smooth muscle, the third contraction was made by 100 in M K- in the presence of nifedipine. The relaxant response to resveratrol was abolished. Thus, the mechanism of vasorelaxation induced by resveratrol probably involves activation of 4-AP-sensitive K+ channels. Its ability to completely relax the mesenteric artery precontracted with K+-rich solution suggests that K channel-independent mechanism(s) are involved in its vasorelaxant effect. It seems that interaction with VGCCs plays a part in this K+ channel-independent effect of resveratrol.",
publisher = "Japanese Pharmacological Soc, Kyoto",
journal = "Journal of Pharmacological Sciences",
title = "A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol",
volume = "108",
number = "1",
pages = "124-130",
doi = "10.1254/jphs.08128FP"
}

Gojković-Bukarica, L., Novaković, A., Kanjuh, V., Bumbasirević, M., Lesić, A.,& Heinle, H.. (2008). A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol. in Journal of Pharmacological Sciences
Japanese Pharmacological Soc, Kyoto., 108(1), 124-130.
https://doi.org/10.1254/jphs.08128FP

Gojković-Bukarica L, Novaković A, Kanjuh V, Bumbasirević M, Lesić A, Heinle H. A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol. in Journal of Pharmacological Sciences. 2008;108(1):124-130.
doi:10.1254/jphs.08128FP .

Gojković-Bukarica, Ljiljana, Novaković, Aleksandra, Kanjuh, Vladimir, Bumbasirević, Marko, Lesić, Aleksandar, Heinle, Helmut, "A role of ion channels in the endothelium-independent relaxation of rat mesenteric artery induced by resveratrol" in Journal of Pharmacological Sciences, 108, no. 1 (2008):124-130,
https://doi.org/10.1254/jphs.08128FP . .