Jaćević, V., Dumanović, J., Grujić-Milanović, J., Milovanović, Z., Amidžić, L., Vojinović, N., Nežić, L., Marković, B., Dobričić, V., Milosavljević, P., Nepovimova, E.,& Kuča, K.. (2023). Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes. in Chemico-biological interactions
Elsevier B.V.., 383, 110658.
https://doi.org/10.1016/j.cbi.2023.110658

Jaćević V, Dumanović J, Grujić-Milanović J, Milovanović Z, Amidžić L, Vojinović N, Nežić L, Marković B, Dobričić V, Milosavljević P, Nepovimova E, Kuča K. Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes. in Chemico-biological interactions. 2023;383:110658.
doi:10.1016/j.cbi.2023.110658 .

Jaćević, Vesna, Dumanović, Jelena, Grujić-Milanović, Jelica, Milovanović, Zoran, Amidžić, Ljiljana, Vojinović, Nataša, Nežić, Lana, Marković, Bojan, Dobričić, Vladimir, Milosavljević, Petar, Nepovimova, Eugenie, Kuča, Kamil, "Oxidative stress status assessment of rats' brains injury following subacute exposure to K-oximes" in Chemico-biological interactions, 383 (2023):110658,
https://doi.org/10.1016/j.cbi.2023.110658 . .

TY  - CONF
AU  - Stefanović, D.
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Milovanović, Zoran A.
AU  - Stojiljković, Miloš P.
AU  - Nedeljković, M.
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/866
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats
T1  - Primena modela pri evaluaciji efikasnosti trimedoksima, atropina i natrijum-hidrogenkarbonata kod trovanja dihlorvosom u pacova
VL  - 56
IS  - 4
SP  - 602
EP  - 603
UR  - https://hdl.handle.net/21.15107/rcub_farfar_866
ER  - 

@conference{
author = "Stefanović, D. and Antonijević, Biljana and Bokonjić, Dubravko and Milovanović, Zoran A. and Stojiljković, Miloš P. and Nedeljković, M.",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats, Primena modela pri evaluaciji efikasnosti trimedoksima, atropina i natrijum-hidrogenkarbonata kod trovanja dihlorvosom u pacova",
volume = "56",
number = "4",
pages = "602-603",
url = "https://hdl.handle.net/21.15107/rcub_farfar_866"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Milovanović, Z. A., Stojiljković, M. P.,& Nedeljković, M.. (2006). Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(4), 602-603.
https://hdl.handle.net/21.15107/rcub_farfar_866

Stefanović D, Antonijević B, Bokonjić D, Milovanović ZA, Stojiljković MP, Nedeljković M. Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Arhiv za farmaciju. 2006;56(4):602-603.
https://hdl.handle.net/21.15107/rcub_farfar_866 .

Stefanović, D., Antonijević, Biljana, Bokonjić, Dubravko, Milovanović, Zoran A., Stojiljković, Miloš P., Nedeljković, M., "Application of modeling for evaluation of the efficacy of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats" in Arhiv za farmaciju, 56, no. 4 (2006):602-603,
https://hdl.handle.net/21.15107/rcub_farfar_866 .

TY  - CONF
AU  - Stefanović, D.
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Milovanović, Zoran A.
AU  - Stojiljković, Miloš P.
AU  - Nedeljković, Mirjana
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/711
PB  - Elsevier
C3  - Toxicology Letters
T1  - Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats
VL  - 164, Supplement
SP  - S244
EP  - S244
DO  - 10.1016/j.toxlet.2006.07.167
ER  - 

@conference{
author = "Stefanović, D. and Antonijević, Biljana and Bokonjić, Dubravko and Milovanović, Zoran A. and Stojiljković, Miloš P. and Nedeljković, Mirjana",
year = "2006",
publisher = "Elsevier",
journal = "Toxicology Letters",
title = "Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats",
volume = "164, Supplement",
pages = "S244-S244",
doi = "10.1016/j.toxlet.2006.07.167"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Milovanović, Z. A., Stojiljković, M. P.,& Nedeljković, M.. (2006). Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Toxicology Letters
Elsevier., 164, Supplement, S244-S244.
https://doi.org/10.1016/j.toxlet.2006.07.167

Stefanović D, Antonijević B, Bokonjić D, Milovanović ZA, Stojiljković MP, Nedeljković M. Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats. in Toxicology Letters. 2006;164, Supplement:S244-S244.
doi:10.1016/j.toxlet.2006.07.167 .

Stefanović, D., Antonijević, Biljana, Bokonjić, Dubravko, Milovanović, Zoran A., Stojiljković, Miloš P., Nedeljković, Mirjana, "Response surface modeling in evaluation of trimedoxime, atropine and sodium bicarbonate against dichlorvos poisoning in rats" in Toxicology Letters, 164, Supplement (2006):S244-S244,
https://doi.org/10.1016/j.toxlet.2006.07.167 . .

TY  - JOUR
AU  - Stefanović, D
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Stojiljković, Miloš P.
AU  - Milovanović, Zoran A.
AU  - Nedeljković, M
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/773
AB  - The development of effective antidotes against organophosphates such as dichlorvos has been a persistent challenge over the past decades. Therapy of organophosphate poisoning is based on the administration of atropine and oxime as standard antidotes. The present study was undertaken to evaluate the ability of sodium bicarbonate to improve protective effects of standard antidotes in rats poisoned with dichlorvos. The aim of this experiment was to establish the correlation between protective effects and biochemical parameters relevant for acid-base status. In order to examine the protective effect of both standard antidotes and their combinations, groups of experimental animals were poisoned subcutaneously with increasing doses of dichlorvos. Immediately thereafter, rats were treated with atropine 10 mg/kg intramuscularly, oximes 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally. These antidotes were administered either as single doses or in combinations. In the biochemical part of the experiments, rats were poisoned with dichlorvos 1.3 LD50 (10.64 mg/kg) subcutaneously and immediately thereafter treated with atropine 10 mg/kg intramuscularly, oximes (trimedoxime or obidoxime) 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally either as single doses or in combinations. Parameters relevant for acid-base status were measured 10 minutes after the administration of antidotes. The results of our study indicate that addition of sodium bicarbonate to standard antidotes significantly improves protective effects of atropine, obidoxime and trimedoxime. Correlation between protection and biochemical outcome is clearly evident when sodium bicarbonate is being added to atropine.
PB  - Wiley, Hoboken
T2  - Basic & Clinical Pharmacology & Toxicology
T1  - Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos
VL  - 98
IS  - 2
SP  - 173
EP  - 180
DO  - 10.1111/j.1742-7843.2006.pto_68.x
ER  - 

@article{
author = "Stefanović, D and Antonijević, Biljana and Bokonjić, Dubravko and Stojiljković, Miloš P. and Milovanović, Zoran A. and Nedeljković, M",
year = "2006",
abstract = "The development of effective antidotes against organophosphates such as dichlorvos has been a persistent challenge over the past decades. Therapy of organophosphate poisoning is based on the administration of atropine and oxime as standard antidotes. The present study was undertaken to evaluate the ability of sodium bicarbonate to improve protective effects of standard antidotes in rats poisoned with dichlorvos. The aim of this experiment was to establish the correlation between protective effects and biochemical parameters relevant for acid-base status. In order to examine the protective effect of both standard antidotes and their combinations, groups of experimental animals were poisoned subcutaneously with increasing doses of dichlorvos. Immediately thereafter, rats were treated with atropine 10 mg/kg intramuscularly, oximes 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally. These antidotes were administered either as single doses or in combinations. In the biochemical part of the experiments, rats were poisoned with dichlorvos 1.3 LD50 (10.64 mg/kg) subcutaneously and immediately thereafter treated with atropine 10 mg/kg intramuscularly, oximes (trimedoxime or obidoxime) 10 mg/kg intramuscularly and sodium bicarbonate 3 mmol/kg intraperitoneally either as single doses or in combinations. Parameters relevant for acid-base status were measured 10 minutes after the administration of antidotes. The results of our study indicate that addition of sodium bicarbonate to standard antidotes significantly improves protective effects of atropine, obidoxime and trimedoxime. Correlation between protection and biochemical outcome is clearly evident when sodium bicarbonate is being added to atropine.",
publisher = "Wiley, Hoboken",
journal = "Basic & Clinical Pharmacology & Toxicology",
title = "Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos",
volume = "98",
number = "2",
pages = "173-180",
doi = "10.1111/j.1742-7843.2006.pto_68.x"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Stojiljković, M. P., Milovanović, Z. A.,& Nedeljković, M.. (2006). Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos. in Basic & Clinical Pharmacology & Toxicology
Wiley, Hoboken., 98(2), 173-180.
https://doi.org/10.1111/j.1742-7843.2006.pto_68.x

Stefanović D, Antonijević B, Bokonjić D, Stojiljković MP, Milovanović ZA, Nedeljković M. Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos. in Basic & Clinical Pharmacology & Toxicology. 2006;98(2):173-180.
doi:10.1111/j.1742-7843.2006.pto_68.x .

Stefanović, D, Antonijević, Biljana, Bokonjić, Dubravko, Stojiljković, Miloš P., Milovanović, Zoran A., Nedeljković, M, "Effect of sodium bicarbonate in rats acutely poisoned with dichlorvos" in Basic & Clinical Pharmacology & Toxicology, 98, no. 2 (2006):173-180,
https://doi.org/10.1111/j.1742-7843.2006.pto_68.x . .

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Stojiljković, Miloš P.
AU  - Kilibarda, Vesna
AU  - Milovanović, Zoran A.
AU  - Nedeljković, M
AU  - Maksimović, M
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/632
AB  - The aim of the study was to examine antidotal potency of trimedoxime in mice poisoned with three direct dimethoxy-substituted organophosphorus inhibitors. In order to assess the protective efficacy of trimedoxime against dichlorvos, heptenophos or monocrotophos, median effective doses and efficacy half-times were calculated. Trimedoxime (24 mg/kg intravenously) was injected 5 min. before 1.3 LD50 intravenously of poisons. Activities of brain, diaphragmal and erythrocyte acetylcholinesterase, as well as of plasma carboxylesterases were determined at different time intervals (10, 40 and 60 min.) after administration of the antidotes. Protective effect of trimedoxime decreased according to the following order: monocrotophos > heptenophos > dichlorvos. Administration of the oxime produced a significant reactivation of central and peripheral acetylcholinesterase inhibited with dichlorvos and heptenophos, with the exception of erythrocyte acetylcholinesterase inhibited by heptenophos. Surprisingly, trimedoxime did not induce reactivation of monocrotophos-inhibited acetylcholinesterase in any of the tissues tested. These organophosphorus compounds produced a significant inhibition of plasma carboxylesterase activity, while administration of trimedoxime led to regeneration of the enzyme activity. The same dose of trimedoxime assured survival of experimental animals poisoned by all three organophosphorus compounds, although the biochemical findings were quite different.
PB  - Wiley, Hoboken
T2  - Basic & Clinical Pharmacology & Toxicology
T1  - Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos
VL  - 96
IS  - 2
SP  - 111
EP  - 117
DO  - 10.1111/j.1742-7843.2005.pto960204.x
ER  - 

@article{
author = "Antonijević, Biljana and Bokonjić, Dubravko and Stojiljković, Miloš P. and Kilibarda, Vesna and Milovanović, Zoran A. and Nedeljković, M and Maksimović, M",
year = "2005",
abstract = "The aim of the study was to examine antidotal potency of trimedoxime in mice poisoned with three direct dimethoxy-substituted organophosphorus inhibitors. In order to assess the protective efficacy of trimedoxime against dichlorvos, heptenophos or monocrotophos, median effective doses and efficacy half-times were calculated. Trimedoxime (24 mg/kg intravenously) was injected 5 min. before 1.3 LD50 intravenously of poisons. Activities of brain, diaphragmal and erythrocyte acetylcholinesterase, as well as of plasma carboxylesterases were determined at different time intervals (10, 40 and 60 min.) after administration of the antidotes. Protective effect of trimedoxime decreased according to the following order: monocrotophos > heptenophos > dichlorvos. Administration of the oxime produced a significant reactivation of central and peripheral acetylcholinesterase inhibited with dichlorvos and heptenophos, with the exception of erythrocyte acetylcholinesterase inhibited by heptenophos. Surprisingly, trimedoxime did not induce reactivation of monocrotophos-inhibited acetylcholinesterase in any of the tissues tested. These organophosphorus compounds produced a significant inhibition of plasma carboxylesterase activity, while administration of trimedoxime led to regeneration of the enzyme activity. The same dose of trimedoxime assured survival of experimental animals poisoned by all three organophosphorus compounds, although the biochemical findings were quite different.",
publisher = "Wiley, Hoboken",
journal = "Basic & Clinical Pharmacology & Toxicology",
title = "Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos",
volume = "96",
number = "2",
pages = "111-117",
doi = "10.1111/j.1742-7843.2005.pto960204.x"
}

Antonijević, B., Bokonjić, D., Stojiljković, M. P., Kilibarda, V., Milovanović, Z. A., Nedeljković, M.,& Maksimović, M.. (2005). Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. in Basic & Clinical Pharmacology & Toxicology
Wiley, Hoboken., 96(2), 111-117.
https://doi.org/10.1111/j.1742-7843.2005.pto960204.x

Antonijević B, Bokonjić D, Stojiljković MP, Kilibarda V, Milovanović ZA, Nedeljković M, Maksimović M. Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos. in Basic & Clinical Pharmacology & Toxicology. 2005;96(2):111-117.
doi:10.1111/j.1742-7843.2005.pto960204.x .

Antonijević, Biljana, Bokonjić, Dubravko, Stojiljković, Miloš P., Kilibarda, Vesna, Milovanović, Zoran A., Nedeljković, M, Maksimović, M, "Efficacy of trimedoxime in mice poisoned with dichlorvos, heptenophos or monocrotophos" in Basic & Clinical Pharmacology & Toxicology, 96, no. 2 (2005):111-117,
https://doi.org/10.1111/j.1742-7843.2005.pto960204.x . .

TY  - JOUR
AU  - Stefanović, Danka
AU  - Antonijević, Biljana
AU  - Bokonjić, Dubravko
AU  - Stojiljković, Miloš P.
AU  - Milovanović, Zoran A.
AU  - Nedeljković, Mirjana
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/565
AB  - The aim of the present work was to examine potential beneficial role of sodium bicarbonate (3 mmol/kg ip) on protective potency of trimedoxime (10 mg/kg im), obidoxime (10 mg/kg im) and atropine (10 mg/kg im) in rats poisoned with dichlorvos. Special attention was paid to the influence of co-administration of sodium bicarbonate on acid-base status in experimental animals poisoned with dichlorvos (1.3 LD50 sc). Coadministration of sodium bicarbonate significantly increased protective effect of standard antidotes in rats poisoned with dichlorvos. Sodium bicarbonate given along with atropine/oxime produced an increase in blood pH value and correction of acidosis. In conclusion, correlation between protective effect and biochemical outcome was evident when sodium bicarbonate was added to antidotes.
AB  - Cilj rada je bio da se ispita efekat natrijum bikarbonata (3 mmol/kg ip) na zaštitni potencijal trimedoksima (10 mg/kg im), obidoksima (10 mg/kg im) i atropina (10 mg/kg im) u pacova trovanih dihlorvosom. Posebna pažnja je posvećena uticaju kombinacija natrijum bikarbonata i antidota na acido-bazni status eksperimentalnih životinja trovanih dihlorvosom (1.3 LD50 ). Primena kombinacija sa natrijum bikarbonatom zna- čajno je povećala zaštitne efekte standardnih antidota, a došlo je i do porasta vrednosti pH krvi i korekcije acidoze. Takođe, moglo se zaključiti da kada je natrijum bikarbonat dat zajedno sa atropinom/oksimom postoji jasna korelacija između dobijenih zaštitnih efekata i testiranih biohemijskih parametara.
PB  - Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd
T2  - Jugoslovenska medicinska biohemija
T1  - Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos
T1  - Uticaj natrijum bikarbonata i standardnih antidota na acido-bazni status pacova trovanih dihlorvosom
VL  - 23
IS  - 2
SP  - 165
EP  - 170
DO  - 10.2298/JMH0402165S
ER  - 

@article{
author = "Stefanović, Danka and Antonijević, Biljana and Bokonjić, Dubravko and Stojiljković, Miloš P. and Milovanović, Zoran A. and Nedeljković, Mirjana",
year = "2004",
abstract = "The aim of the present work was to examine potential beneficial role of sodium bicarbonate (3 mmol/kg ip) on protective potency of trimedoxime (10 mg/kg im), obidoxime (10 mg/kg im) and atropine (10 mg/kg im) in rats poisoned with dichlorvos. Special attention was paid to the influence of co-administration of sodium bicarbonate on acid-base status in experimental animals poisoned with dichlorvos (1.3 LD50 sc). Coadministration of sodium bicarbonate significantly increased protective effect of standard antidotes in rats poisoned with dichlorvos. Sodium bicarbonate given along with atropine/oxime produced an increase in blood pH value and correction of acidosis. In conclusion, correlation between protective effect and biochemical outcome was evident when sodium bicarbonate was added to antidotes., Cilj rada je bio da se ispita efekat natrijum bikarbonata (3 mmol/kg ip) na zaštitni potencijal trimedoksima (10 mg/kg im), obidoksima (10 mg/kg im) i atropina (10 mg/kg im) u pacova trovanih dihlorvosom. Posebna pažnja je posvećena uticaju kombinacija natrijum bikarbonata i antidota na acido-bazni status eksperimentalnih životinja trovanih dihlorvosom (1.3 LD50 ). Primena kombinacija sa natrijum bikarbonatom zna- čajno je povećala zaštitne efekte standardnih antidota, a došlo je i do porasta vrednosti pH krvi i korekcije acidoze. Takođe, moglo se zaključiti da kada je natrijum bikarbonat dat zajedno sa atropinom/oksimom postoji jasna korelacija između dobijenih zaštitnih efekata i testiranih biohemijskih parametara.",
publisher = "Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd",
journal = "Jugoslovenska medicinska biohemija",
title = "Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos, Uticaj natrijum bikarbonata i standardnih antidota na acido-bazni status pacova trovanih dihlorvosom",
volume = "23",
number = "2",
pages = "165-170",
doi = "10.2298/JMH0402165S"
}

Stefanović, D., Antonijević, B., Bokonjić, D., Stojiljković, M. P., Milovanović, Z. A.,& Nedeljković, M.. (2004). Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos. in Jugoslovenska medicinska biohemija
Društvo medicinskih biohemičara Srbije i Crne Gore, Beograd i Univerzitet u Beogradu - Farmaceutski fakultet, Beograd., 23(2), 165-170.
https://doi.org/10.2298/JMH0402165S

Stefanović D, Antonijević B, Bokonjić D, Stojiljković MP, Milovanović ZA, Nedeljković M. Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos. in Jugoslovenska medicinska biohemija. 2004;23(2):165-170.
doi:10.2298/JMH0402165S .

Stefanović, Danka, Antonijević, Biljana, Bokonjić, Dubravko, Stojiljković, Miloš P., Milovanović, Zoran A., Nedeljković, Mirjana, "Influence of sodium bicarbonate and standard antidotes on acid-base status in rats poisoned with dichlorvos" in Jugoslovenska medicinska biohemija, 23, no. 2 (2004):165-170,
https://doi.org/10.2298/JMH0402165S . .

TY  - CONF
AU  - Antonijević, Biljana
AU  - Stefanović, Danka
AU  - Nedeljković, Mirjana
AU  - Stojiljković, Miloš P.
AU  - Bokonjić, Dubravko
AU  - Milovanović, Zoran A.
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/368
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos
T1  - Zaštitni efekat standardnih antidota primenjenih sa natrijum bikarbonatom u pacova trovanih dihlorvosom
VL  - 52
IS  - 4
SP  - 762
EP  - 763
UR  - https://hdl.handle.net/21.15107/rcub_farfar_368
ER  - 

@conference{
author = "Antonijević, Biljana and Stefanović, Danka and Nedeljković, Mirjana and Stojiljković, Miloš P. and Bokonjić, Dubravko and Milovanović, Zoran A.",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos, Zaštitni efekat standardnih antidota primenjenih sa natrijum bikarbonatom u pacova trovanih dihlorvosom",
volume = "52",
number = "4",
pages = "762-763",
url = "https://hdl.handle.net/21.15107/rcub_farfar_368"
}

Antonijević, B., Stefanović, D., Nedeljković, M., Stojiljković, M. P., Bokonjić, D.,& Milovanović, Z. A.. (2002). Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 762-763.
https://hdl.handle.net/21.15107/rcub_farfar_368

Antonijević B, Stefanović D, Nedeljković M, Stojiljković MP, Bokonjić D, Milovanović ZA. Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos. in Arhiv za farmaciju. 2002;52(4):762-763.
https://hdl.handle.net/21.15107/rcub_farfar_368 .

Antonijević, Biljana, Stefanović, Danka, Nedeljković, Mirjana, Stojiljković, Miloš P., Bokonjić, Dubravko, Milovanović, Zoran A., "Protective effect of standard antidotes along with sodium bicarbonate in rats poisoned with dichlorvos" in Arhiv za farmaciju, 52, no. 4 (2002):762-763,
https://hdl.handle.net/21.15107/rcub_farfar_368 .

TY  - JOUR
AU  - Antonijević, Biljana
AU  - Maksimović, Matej
AU  - Kilibarda, Vesna
AU  - Stojiljković, Miloš P.
AU  - Nedeljković, Mirjana
AU  - Milovanović, Zoran A.
AU  - Bokonjić, Dubravko
PY  - 2001
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/305
AB  - The aim of this study was to investigate the efficacy of four pyridinium oximes - pralidoxime (PAM-2), trimedoxime (TMB-4), obidoxime (LuH-6) and HI-6 - alone or in combination with memantine and its principal metabolite 1-amino-3-hydroxymethyl-5-methyl adamantane (Mrz 2/373) against soman in mice. Male Albino mice were pretreated iv with oximes and adamantanes at various times before 1.3 LD-50 of soman iv in order to obtain their ED-50t. In a separate experiment, the brain, dia­phragmai and erythrocytic acetylcholinesterase and plasma carboxylesterase activities were determined after sacrificing mice 5 min after soman 0.75 LD-50. Oxime HI-6 (ED-50 value at 5 min before soman) and adamantanes were administered 5 min before soman. In the combination regimens and in the biochemical experiments the dose of memantine and Mrz 2/373 was fixed at 10 mg/kg iv. Along the tested time intervals, HI-6 afforded the best protection of experimental animals, and calculated EDSOo value of HI-6 was 7.96 µmol/kg. Memantine significantly (up to 9 times) de­creased ED-500 values of all the oximes used, with the exception of TMB-4. Among tested tis­sues, the highest recovery of inhibited acetylcholinesterase was obtained in the diaphragm. Co-administration of adamantanes (memantine, Mrz 2/373) produced a statistically significant in­crease in the erythrocyte acetylcholinesterase activity. It could be concluded that memantine antidotal efficacy could be ascribed to the protection of acetylcholinesterase activity. .
AB  - Pored činjenice daje oksim HI-6 najefikasniji u antagonizovanju toksičnih efekata somana, terapija trovanja ovim nervnim bojnim otrovom još nije u potpunosti zadovoljavajuća. Dosadašnji eksperimenti sa memantinom su pokazali da ovaj derivat adamantana potencira terapijski efekat standardnih antidota pri trovanju organofosfornim jedinjenjima. U ovom radu ispitivana je antidotska efikasnost piridinijumskih oksima - pralidoksima, trimedoksima, obidoksima i HI-6, kao i njihovih kombinacija sa memantinom ili njegovim aktivnim metabolitom Mrz 2/373 u miševa trovanih somanom. Radi dobijanja parametara zaštitne efikasnosti antidota, albino miševima mužjacima su iv aplikovane rastuće doze antidota u određenim vremenskim intervalima ( 1 -60 min) pre 1,3 LD-50 iv somana. Aktivnosti acetilholinesteraze mozga, dijafragme i eritrocita, kao i karboksilesteraza plazme, određivane su nakon iv primene adamantana (10 mg/kg) i/ili oksima HI-6 (3,1 mg/kg; 7,96 µmol/kg) datih 5 min pre 0,75 LD-50 iv somana. Primena oksima HI-6 je obezbedila najbolju zaštitu eksperimentalnih životinja, a srednja efektivna doza u nultom vremenu ED-500 iznosila je 7,96 µmol/kg. Kada je primenjen u kombinaciji sa oksimima, memantin je doveo do značajnog (oko 9 puta) smanjenja HD-500 vrednosti svih oksima, osim trimedoksima. ali je zato poluvreme efikasnosti trimedoksima povećano 4,82 puta. Značajan porast acetilholinesteraze dijafragme dobijen je primenom HI-6, memantina kao i njihove kombinacije. U odnosu na grupu koja je primila samo soman, aktivnost acetilholi­nesteraze eritrocita bila je značajno veća u grupama kojima su davani adamantani i/ili HI-6. Nijedan od primenjenih tretmana nije doveo do statistički značajnog povećanja aktivnosti acetilholinesteraze mozga i karboksilesteraza plazme. Bolji zaštitni efekt kombinacija oksima i memantina u odnosu na same oksime mogao bi se pripisati antikonvulzivnom potencijalu memantina, koji je nekompetitivni antagonista NMDA receptora, ali i izvesnoj zaštiti aktivnog centra acetilholinesteraze dijafragme.
PB  - Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd
T2  - Archives of Toxicology, Kinetics and Xenobiotic Metabolism
T1  - Potential beneficial action of adamantanes in mice poisoned with soman
T1  - Potencijalna uloga adamantana u trovanju miševa somanom
VL  - 9
IS  - 1-2
SP  - 13
EP  - 20
UR  - https://hdl.handle.net/21.15107/rcub_farfar_305
ER  - 

@article{
author = "Antonijević, Biljana and Maksimović, Matej and Kilibarda, Vesna and Stojiljković, Miloš P. and Nedeljković, Mirjana and Milovanović, Zoran A. and Bokonjić, Dubravko",
year = "2001",
abstract = "The aim of this study was to investigate the efficacy of four pyridinium oximes - pralidoxime (PAM-2), trimedoxime (TMB-4), obidoxime (LuH-6) and HI-6 - alone or in combination with memantine and its principal metabolite 1-amino-3-hydroxymethyl-5-methyl adamantane (Mrz 2/373) against soman in mice. Male Albino mice were pretreated iv with oximes and adamantanes at various times before 1.3 LD-50 of soman iv in order to obtain their ED-50t. In a separate experiment, the brain, dia­phragmai and erythrocytic acetylcholinesterase and plasma carboxylesterase activities were determined after sacrificing mice 5 min after soman 0.75 LD-50. Oxime HI-6 (ED-50 value at 5 min before soman) and adamantanes were administered 5 min before soman. In the combination regimens and in the biochemical experiments the dose of memantine and Mrz 2/373 was fixed at 10 mg/kg iv. Along the tested time intervals, HI-6 afforded the best protection of experimental animals, and calculated EDSOo value of HI-6 was 7.96 µmol/kg. Memantine significantly (up to 9 times) de­creased ED-500 values of all the oximes used, with the exception of TMB-4. Among tested tis­sues, the highest recovery of inhibited acetylcholinesterase was obtained in the diaphragm. Co-administration of adamantanes (memantine, Mrz 2/373) produced a statistically significant in­crease in the erythrocyte acetylcholinesterase activity. It could be concluded that memantine antidotal efficacy could be ascribed to the protection of acetylcholinesterase activity. ., Pored činjenice daje oksim HI-6 najefikasniji u antagonizovanju toksičnih efekata somana, terapija trovanja ovim nervnim bojnim otrovom još nije u potpunosti zadovoljavajuća. Dosadašnji eksperimenti sa memantinom su pokazali da ovaj derivat adamantana potencira terapijski efekat standardnih antidota pri trovanju organofosfornim jedinjenjima. U ovom radu ispitivana je antidotska efikasnost piridinijumskih oksima - pralidoksima, trimedoksima, obidoksima i HI-6, kao i njihovih kombinacija sa memantinom ili njegovim aktivnim metabolitom Mrz 2/373 u miševa trovanih somanom. Radi dobijanja parametara zaštitne efikasnosti antidota, albino miševima mužjacima su iv aplikovane rastuće doze antidota u određenim vremenskim intervalima ( 1 -60 min) pre 1,3 LD-50 iv somana. Aktivnosti acetilholinesteraze mozga, dijafragme i eritrocita, kao i karboksilesteraza plazme, određivane su nakon iv primene adamantana (10 mg/kg) i/ili oksima HI-6 (3,1 mg/kg; 7,96 µmol/kg) datih 5 min pre 0,75 LD-50 iv somana. Primena oksima HI-6 je obezbedila najbolju zaštitu eksperimentalnih životinja, a srednja efektivna doza u nultom vremenu ED-500 iznosila je 7,96 µmol/kg. Kada je primenjen u kombinaciji sa oksimima, memantin je doveo do značajnog (oko 9 puta) smanjenja HD-500 vrednosti svih oksima, osim trimedoksima. ali je zato poluvreme efikasnosti trimedoksima povećano 4,82 puta. Značajan porast acetilholinesteraze dijafragme dobijen je primenom HI-6, memantina kao i njihove kombinacije. U odnosu na grupu koja je primila samo soman, aktivnost acetilholi­nesteraze eritrocita bila je značajno veća u grupama kojima su davani adamantani i/ili HI-6. Nijedan od primenjenih tretmana nije doveo do statistički značajnog povećanja aktivnosti acetilholinesteraze mozga i karboksilesteraza plazme. Bolji zaštitni efekt kombinacija oksima i memantina u odnosu na same oksime mogao bi se pripisati antikonvulzivnom potencijalu memantina, koji je nekompetitivni antagonista NMDA receptora, ali i izvesnoj zaštiti aktivnog centra acetilholinesteraze dijafragme.",
publisher = "Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd",
journal = "Archives of Toxicology, Kinetics and Xenobiotic Metabolism",
title = "Potential beneficial action of adamantanes in mice poisoned with soman, Potencijalna uloga adamantana u trovanju miševa somanom",
volume = "9",
number = "1-2",
pages = "13-20",
url = "https://hdl.handle.net/21.15107/rcub_farfar_305"
}

Antonijević, B., Maksimović, M., Kilibarda, V., Stojiljković, M. P., Nedeljković, M., Milovanović, Z. A.,& Bokonjić, D.. (2001). Potential beneficial action of adamantanes in mice poisoned with soman. in Archives of Toxicology, Kinetics and Xenobiotic Metabolism
Srpsko lekarsko društvo - Sekcija za toksikologiju, Beograd., 9(1-2), 13-20.
https://hdl.handle.net/21.15107/rcub_farfar_305

Antonijević B, Maksimović M, Kilibarda V, Stojiljković MP, Nedeljković M, Milovanović ZA, Bokonjić D. Potential beneficial action of adamantanes in mice poisoned with soman. in Archives of Toxicology, Kinetics and Xenobiotic Metabolism. 2001;9(1-2):13-20.
https://hdl.handle.net/21.15107/rcub_farfar_305 .

Antonijević, Biljana, Maksimović, Matej, Kilibarda, Vesna, Stojiljković, Miloš P., Nedeljković, Mirjana, Milovanović, Zoran A., Bokonjić, Dubravko, "Potential beneficial action of adamantanes in mice poisoned with soman" in Archives of Toxicology, Kinetics and Xenobiotic Metabolism, 9, no. 1-2 (2001):13-20,
https://hdl.handle.net/21.15107/rcub_farfar_305 .