TY  - JOUR
AU  - Ranković, Maja
AU  - Jevremović, Anka
AU  - Janošević-Ležaić, Aleksandra
AU  - Arsenijević, Aleksandar
AU  - Rupar, Jelena
AU  - Dobričić, Vladimir
AU  - Nedić Vasiljević, Bojana
AU  - Gavrilov, Nemanja
AU  - Bajuk-Bogdanović, Danica
AU  - Milojević-Rakić, Maja
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4649
AB  - Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was employed for drug quantification. The effects of the tested compounds on cell viability were evaluated using in vitro methylthiazol-tetrazolium (MTT) colorimetric technique against human colorectal carcinoma (cell line HCT-116) and MRC-5 fibroblasts. Zeolite structure remained unchanged during homogeneous drug impregnation with achieved drug loadings in the 18–21 mg/g range. The highest drug release, in the µM concentration range, with favourable kinetics was established for zeolite-supported 9-aminoacridine. The acridine delivery via zeolite carrier is viewed in terms of solvation energy and zeolite adsorption sites. The cytotoxic effect of supported acridines on HCT-116 cells reveals that the zeolite carrier improves toxicity, while the highest efficiency is displayed by zeolite-impregnated 9-aminoacridine. The 9-aminoacridine delivery via zeolite carrier favours healthy tissue preservation while accompanying increased toxicity toward cancer cells. Cytotoxicity results are well correlated with theoretical modelling and release study, providing promising results for applicative purposes.
PB  - MDPI
T2  - Journal of Functional Biomaterials
T1  - Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?
VL  - 14
IS  - 3
DO  - 10.3390/jfb14030173
ER  - 

@article{
author = "Ranković, Maja and Jevremović, Anka and Janošević-Ležaić, Aleksandra and Arsenijević, Aleksandar and Rupar, Jelena and Dobričić, Vladimir and Nedić Vasiljević, Bojana and Gavrilov, Nemanja and Bajuk-Bogdanović, Danica and Milojević-Rakić, Maja",
year = "2023",
abstract = "Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the zeolite surface, while spectrofluorimetry was employed for drug quantification. The effects of the tested compounds on cell viability were evaluated using in vitro methylthiazol-tetrazolium (MTT) colorimetric technique against human colorectal carcinoma (cell line HCT-116) and MRC-5 fibroblasts. Zeolite structure remained unchanged during homogeneous drug impregnation with achieved drug loadings in the 18–21 mg/g range. The highest drug release, in the µM concentration range, with favourable kinetics was established for zeolite-supported 9-aminoacridine. The acridine delivery via zeolite carrier is viewed in terms of solvation energy and zeolite adsorption sites. The cytotoxic effect of supported acridines on HCT-116 cells reveals that the zeolite carrier improves toxicity, while the highest efficiency is displayed by zeolite-impregnated 9-aminoacridine. The 9-aminoacridine delivery via zeolite carrier favours healthy tissue preservation while accompanying increased toxicity toward cancer cells. Cytotoxicity results are well correlated with theoretical modelling and release study, providing promising results for applicative purposes.",
publisher = "MDPI",
journal = "Journal of Functional Biomaterials",
title = "Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?",
volume = "14",
number = "3",
doi = "10.3390/jfb14030173"
}

Ranković, M., Jevremović, A., Janošević-Ležaić, A., Arsenijević, A., Rupar, J., Dobričić, V., Nedić Vasiljević, B., Gavrilov, N., Bajuk-Bogdanović, D.,& Milojević-Rakić, M.. (2023). Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?. in Journal of Functional Biomaterials
MDPI., 14(3).
https://doi.org/10.3390/jfb14030173

Ranković M, Jevremović A, Janošević-Ležaić A, Arsenijević A, Rupar J, Dobričić V, Nedić Vasiljević B, Gavrilov N, Bajuk-Bogdanović D, Milojević-Rakić M. Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?. in Journal of Functional Biomaterials. 2023;14(3).
doi:10.3390/jfb14030173 .

Ranković, Maja, Jevremović, Anka, Janošević-Ležaić, Aleksandra, Arsenijević, Aleksandar, Rupar, Jelena, Dobričić, Vladimir, Nedić Vasiljević, Bojana, Gavrilov, Nemanja, Bajuk-Bogdanović, Danica, Milojević-Rakić, Maja, "Can Zeolite-Supporting Acridines Boost Their Anticancer Performance?" in Journal of Functional Biomaterials, 14, no. 3 (2023),
https://doi.org/10.3390/jfb14030173 . .

TY  - JOUR
AU  - Mijailović, Nataša R.
AU  - Nedić Vasiljević, Bojana
AU  - Ranković, Maja
AU  - Milanović, Vladimir
AU  - Uskoković-Marković, Snežana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4266
AB  - Zeolites belong to aluminosilicate microporous solids, with strong and diverse catalytic
activity, which makes them applicable in almost every kind of industrial process, particularly thanks
to their eco-friendly profile. Another crucial characteristic of zeolites is their tremendous adsorption
capability. Therefore, it is self-evident that the widespread use of zeolites is in environmental
protection, based primarily on the adsorption capacity of substances potentially harmful to the
environment, such as pharmaceuticals, pesticides, or other industry pollutants. On the other hand,
zeolites are also recognized as drug delivery systems (DDS) carriers for numerous pharmacologically
active agents. The enhanced bioactive ability of DDS zeolite as a drug carrying nanoplatform is
confirmed, making this system more specific and efficient, compared to the drug itself. These two
applications of zeolite, in fact, illustrate the importance of (ir)reversibility of the adsorption process.
This review gives deep insight into the balance and dynamics that are established during that
process, i.e., the interaction between zeolites and pharmaceuticals, helping scientists to expand their
knowledge necessarily for a more effective application of the adsorption phenomenon of zeolites.
PB  - MDPI
T2  - Catalysts
T1  - Environmental and Pharmacokinetic Aspects of Zeolite/Pharmaceuticals Systems—Two Facets of Adsorption Ability
VL  - 12
IS  - 8
DO  - 10.3390/catal12080837
ER  - 

@article{
author = "Mijailović, Nataša R. and Nedić Vasiljević, Bojana and Ranković, Maja and Milanović, Vladimir and Uskoković-Marković, Snežana",
year = "2022",
abstract = "Zeolites belong to aluminosilicate microporous solids, with strong and diverse catalytic
activity, which makes them applicable in almost every kind of industrial process, particularly thanks
to their eco-friendly profile. Another crucial characteristic of zeolites is their tremendous adsorption
capability. Therefore, it is self-evident that the widespread use of zeolites is in environmental
protection, based primarily on the adsorption capacity of substances potentially harmful to the
environment, such as pharmaceuticals, pesticides, or other industry pollutants. On the other hand,
zeolites are also recognized as drug delivery systems (DDS) carriers for numerous pharmacologically
active agents. The enhanced bioactive ability of DDS zeolite as a drug carrying nanoplatform is
confirmed, making this system more specific and efficient, compared to the drug itself. These two
applications of zeolite, in fact, illustrate the importance of (ir)reversibility of the adsorption process.
This review gives deep insight into the balance and dynamics that are established during that
process, i.e., the interaction between zeolites and pharmaceuticals, helping scientists to expand their
knowledge necessarily for a more effective application of the adsorption phenomenon of zeolites.",
publisher = "MDPI",
journal = "Catalysts",
title = "Environmental and Pharmacokinetic Aspects of Zeolite/Pharmaceuticals Systems—Two Facets of Adsorption Ability",
volume = "12",
number = "8",
doi = "10.3390/catal12080837"
}

Mijailović, N. R., Nedić Vasiljević, B., Ranković, M., Milanović, V.,& Uskoković-Marković, S.. (2022). Environmental and Pharmacokinetic Aspects of Zeolite/Pharmaceuticals Systems—Two Facets of Adsorption Ability. in Catalysts
MDPI., 12(8).
https://doi.org/10.3390/catal12080837

Mijailović NR, Nedić Vasiljević B, Ranković M, Milanović V, Uskoković-Marković S. Environmental and Pharmacokinetic Aspects of Zeolite/Pharmaceuticals Systems—Two Facets of Adsorption Ability. in Catalysts. 2022;12(8).
doi:10.3390/catal12080837 .

Mijailović, Nataša R., Nedić Vasiljević, Bojana, Ranković, Maja, Milanović, Vladimir, Uskoković-Marković, Snežana, "Environmental and Pharmacokinetic Aspects of Zeolite/Pharmaceuticals Systems—Two Facets of Adsorption Ability" in Catalysts, 12, no. 8 (2022),
https://doi.org/10.3390/catal12080837 . .