TY  - JOUR
AU  - Brborić, Jasmina
AU  - Jovanović, Mirjana
AU  - Čudina, Olivera
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1813
AB  - Hepatobiliary scintigraphy (Cholescintigraphy) is a nuclear imaging procedure for morphological and functional investigation of hepatobiliary system. 99mTc-IDA derivatives are commonly used for hepatobiliary imaging. Biological properties of IDA analogues are determined by chemical structure. Corresponding molecular mass, lipophilicity, protein binding, as well as nature and position of substituents attached to the phenyl ring have major influence on biokinetics (the degree of hepatic uptake and the rate of excretion, as well as urinary elimination) of the 99mTc-IDA complexes. Since bilirubin competes with IDA derivatives, hyperbilirubinemia represents the limiting factor in the application of 99mTc-IDA analogues as hepatobiliary imaging agents. This paper's goal is to give a review of the most important data about physico-chemical and biological properties of numerous 99mTc-IDA analogues which are synthesized and evaluated as potential radiopharmaceuticals, and also those which are commercially used as diagnostics agents. Of all IDA derivatives, 99mTc-mebrofenin is the agents of choice for hepatobiliary imaging in hiperbilirubinemia conditions.
AB  - Hepatobilijarna scintigrafija (HBS) predstavlja značajnu nuklearno-medicinsku metodu za morfološka i funkciona ispitivanja hepatobilijarnog sistema. Uobičajeno se za ova ispitivanja koriste 99mTc-IDA analozi. Biološke osobine IDA analoga određene su njihovom hemijskom strukturom. Odgovarajuća molekulska masa, lipofilnost, proteinsko vezivanje, kao i vrsta i položaj supstituenata u aromatičnom sistemu imaju presudan uticaj na biokinetiku (visoko nakupljanje i brz transport kroz hepatocite, visoku bilijarnu i minimalnu renalnu ekskreciju) 99mTc-IDA kompleksa. Pošto bilirubin ulazi u kompeticiju sa IDA analozima, hiperbilirubinemija može ograničavati primenu 99mTc-IDA analoga kao hepatobilijarnih agenasa. Ovaj rad ima za cilj da pruži pregled najvažnijih podataka o fizičko-hemijskim i biološkim osobinama brojnih 99mTc-IDA analoga koji su sintetisani i ispitani kao potencijalni radiofarmaceutici, kao i onih koji se komercijalno koriste kao dijagnostička sredstva. Od svih IDA analoga, 99mTc-mebrofenin predstavlja agens izbora za hepatobilijarna ispitivanja u uslovima hiperbilirubinemije.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Radiopharmaceuticals for hepatobiliary scintigraphy: Iminodiacetic acid analogues labeled with technetium-99m
T1  - Radiofarmaceutici za hepatobilijarnu scintigrafiju - analozi iminodisirćetne kiseline obeleženi tehnecijumom-99m
VL  - 62
IS  - 6
SP  - 527
EP  - 547
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1813
ER  - 

@article{
author = "Brborić, Jasmina and Jovanović, Mirjana and Čudina, Olivera",
year = "2012",
abstract = "Hepatobiliary scintigraphy (Cholescintigraphy) is a nuclear imaging procedure for morphological and functional investigation of hepatobiliary system. 99mTc-IDA derivatives are commonly used for hepatobiliary imaging. Biological properties of IDA analogues are determined by chemical structure. Corresponding molecular mass, lipophilicity, protein binding, as well as nature and position of substituents attached to the phenyl ring have major influence on biokinetics (the degree of hepatic uptake and the rate of excretion, as well as urinary elimination) of the 99mTc-IDA complexes. Since bilirubin competes with IDA derivatives, hyperbilirubinemia represents the limiting factor in the application of 99mTc-IDA analogues as hepatobiliary imaging agents. This paper's goal is to give a review of the most important data about physico-chemical and biological properties of numerous 99mTc-IDA analogues which are synthesized and evaluated as potential radiopharmaceuticals, and also those which are commercially used as diagnostics agents. Of all IDA derivatives, 99mTc-mebrofenin is the agents of choice for hepatobiliary imaging in hiperbilirubinemia conditions., Hepatobilijarna scintigrafija (HBS) predstavlja značajnu nuklearno-medicinsku metodu za morfološka i funkciona ispitivanja hepatobilijarnog sistema. Uobičajeno se za ova ispitivanja koriste 99mTc-IDA analozi. Biološke osobine IDA analoga određene su njihovom hemijskom strukturom. Odgovarajuća molekulska masa, lipofilnost, proteinsko vezivanje, kao i vrsta i položaj supstituenata u aromatičnom sistemu imaju presudan uticaj na biokinetiku (visoko nakupljanje i brz transport kroz hepatocite, visoku bilijarnu i minimalnu renalnu ekskreciju) 99mTc-IDA kompleksa. Pošto bilirubin ulazi u kompeticiju sa IDA analozima, hiperbilirubinemija može ograničavati primenu 99mTc-IDA analoga kao hepatobilijarnih agenasa. Ovaj rad ima za cilj da pruži pregled najvažnijih podataka o fizičko-hemijskim i biološkim osobinama brojnih 99mTc-IDA analoga koji su sintetisani i ispitani kao potencijalni radiofarmaceutici, kao i onih koji se komercijalno koriste kao dijagnostička sredstva. Od svih IDA analoga, 99mTc-mebrofenin predstavlja agens izbora za hepatobilijarna ispitivanja u uslovima hiperbilirubinemije.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Radiopharmaceuticals for hepatobiliary scintigraphy: Iminodiacetic acid analogues labeled with technetium-99m, Radiofarmaceutici za hepatobilijarnu scintigrafiju - analozi iminodisirćetne kiseline obeleženi tehnecijumom-99m",
volume = "62",
number = "6",
pages = "527-547",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1813"
}

Brborić, J., Jovanović, M.,& Čudina, O.. (2012). Radiopharmaceuticals for hepatobiliary scintigraphy: Iminodiacetic acid analogues labeled with technetium-99m. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 62(6), 527-547.
https://hdl.handle.net/21.15107/rcub_farfar_1813

Brborić J, Jovanović M, Čudina O. Radiopharmaceuticals for hepatobiliary scintigraphy: Iminodiacetic acid analogues labeled with technetium-99m. in Arhiv za farmaciju. 2012;62(6):527-547.
https://hdl.handle.net/21.15107/rcub_farfar_1813 .

Brborić, Jasmina, Jovanović, Mirjana, Čudina, Olivera, "Radiopharmaceuticals for hepatobiliary scintigraphy: Iminodiacetic acid analogues labeled with technetium-99m" in Arhiv za farmaciju, 62, no. 6 (2012):527-547,
https://hdl.handle.net/21.15107/rcub_farfar_1813 .

TY  - JOUR
AU  - Brborić, Jasmina
AU  - Jovanović, Mirjana S.
AU  - Popović, Gordana
AU  - Kapetanović, Vera
AU  - Vladimirov, Sote
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/875
AB  - The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK2 = 2.52 ± 0.02; pK3 = 5.86 ± 0.06 and pK4 = 10.9 ± 0.1. The determinations were performed at 25 ºC and an ionic strength of 0.1 mol/dm3 (NaCl). The acidity constants (pK1 = 1.3 ± 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 ºC and an ionic strength 1 mol/dm3 (HCl, NaCl). DIIODIDA was labeled with technetium-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity (>98 %).
AB  - Ispitane su kiselinsko-bazne ravnoteže novog hepatobilijarnog agensa, 2,4-dijod- 6-metilfenilkarbamoilmetil iminodisirćetne kiseline. Kiselinske konstante koje odgovaraju drugoj karboksilnoj grupi, amino i amidnoj grupi određene su potenciometrijski: pK2 = 2.52 ± 0.02; pK3 = 5.86 ± 0.06 I pK4 = 10.9 ± 0.1. Određivanja su izvedena na 25 ºC i pri konstantnoj jonskoj sili 0,1 mol/dm3 (NaCl). Kiselinska konstanta prve karboksilne grupe (pK1 = 1,3_0,4) određena je indirektno na osnovu ravnotežnih konstanti određenih u heterogenom sistemu, na 25 ºC i jonskoj sili 1 mol/dm3 (HCl, NaCl). DIIODIDA je obeležena tehnecijumom-99m i ispitan je uticaj pH na prinos obeležavanja. Utvrđeno je da se obeležavanjem u pH opsegu 5,5-6,5 dobija radiofarmaceutik visoke radiohemijske čistoće (> 98 %).
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m
T1  - Kiselinsko-bazne ravnoteže 2,4-dijod-6-metilfenilkarbamoilmetil iminodisirćetne kiseline i obeležavanje tehnecijumom-99m
VL  - 71
IS  - 1
SP  - 55
EP  - 65
DO  - 10.2298/JSC0601055B
ER  - 

@article{
author = "Brborić, Jasmina and Jovanović, Mirjana S. and Popović, Gordana and Kapetanović, Vera and Vladimirov, Sote",
year = "2006",
abstract = "The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK2 = 2.52 ± 0.02; pK3 = 5.86 ± 0.06 and pK4 = 10.9 ± 0.1. The determinations were performed at 25 ºC and an ionic strength of 0.1 mol/dm3 (NaCl). The acidity constants (pK1 = 1.3 ± 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 ºC and an ionic strength 1 mol/dm3 (HCl, NaCl). DIIODIDA was labeled with technetium-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity (>98 %)., Ispitane su kiselinsko-bazne ravnoteže novog hepatobilijarnog agensa, 2,4-dijod- 6-metilfenilkarbamoilmetil iminodisirćetne kiseline. Kiselinske konstante koje odgovaraju drugoj karboksilnoj grupi, amino i amidnoj grupi određene su potenciometrijski: pK2 = 2.52 ± 0.02; pK3 = 5.86 ± 0.06 I pK4 = 10.9 ± 0.1. Određivanja su izvedena na 25 ºC i pri konstantnoj jonskoj sili 0,1 mol/dm3 (NaCl). Kiselinska konstanta prve karboksilne grupe (pK1 = 1,3_0,4) određena je indirektno na osnovu ravnotežnih konstanti određenih u heterogenom sistemu, na 25 ºC i jonskoj sili 1 mol/dm3 (HCl, NaCl). DIIODIDA je obeležena tehnecijumom-99m i ispitan je uticaj pH na prinos obeležavanja. Utvrđeno je da se obeležavanjem u pH opsegu 5,5-6,5 dobija radiofarmaceutik visoke radiohemijske čistoće (> 98 %).",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m, Kiselinsko-bazne ravnoteže 2,4-dijod-6-metilfenilkarbamoilmetil iminodisirćetne kiseline i obeležavanje tehnecijumom-99m",
volume = "71",
number = "1",
pages = "55-65",
doi = "10.2298/JSC0601055B"
}

Brborić, J., Jovanović, M. S., Popović, G., Kapetanović, V.,& Vladimirov, S.. (2006). Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 71(1), 55-65.
https://doi.org/10.2298/JSC0601055B

Brborić J, Jovanović MS, Popović G, Kapetanović V, Vladimirov S. Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m. in Journal of the Serbian Chemical Society. 2006;71(1):55-65.
doi:10.2298/JSC0601055B .

Brborić, Jasmina, Jovanović, Mirjana S., Popović, Gordana, Kapetanović, Vera, Vladimirov, Sote, "Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m" in Journal of the Serbian Chemical Society, 71, no. 1 (2006):55-65,
https://doi.org/10.2298/JSC0601055B . .