TY  - JOUR
AU  - Popović, Dejana
AU  - Lavie, Carl
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4653
AB  - The assuredness that adverse life stressors can lead to major negative impacts on an individual's health has been held since antiquity. Stress is considered a state of homeostasis being challenged, with biological consequences that can cause cardiovascular diseases (CVD). Stressors may be diverse and include a variety of psychological stressors, such as family stress, job strain, effort-award imbalance, long working hours, insecurity, social isolation, and lack of purpose in life. However, stressors may also be physical, immunological, metabolic, or environmental. Type of personality, anxiety, depression, pessimism or hostility, previous experience, genomics, body composition, nutritive and training status modulate stress responses and are important co-stressors. Chronic stress is linked with altered neurohormonal activity, which increases apoptotic pathways in cardiomyocytes. These pathways contribute to impaired myocardial contractility, increased risk of myocardial ischemia, infarction, heart failure, and arrhythmias. While stress is a vital risk factor for CVD, it has not been a major focus of preventive strategies. The purpose of this article is to review the impact of stress on CVD risk with an emphasis on approaches for stress reduction. Strength and endurance exercise, although being stress itself, leads to better adaptiveness to other types of stress, and by far has played an inevitable role in CVD risk reduction. Innovative strategies to combat CVD are strongly needed and exercise may be the best population-level cost-effective approach.
PB  - Wolters Kluwer Medknow Publications
T2  - Heart and Mind
T1  - Stress, cardiovascular diseases and exercise - A narrative review
VL  - 7
IS  - 1
SP  - 18
EP  - 24
DO  - 10.4103/hm.hm_33_22
ER  - 

@article{
author = "Popović, Dejana and Lavie, Carl",
year = "2023",
abstract = "The assuredness that adverse life stressors can lead to major negative impacts on an individual's health has been held since antiquity. Stress is considered a state of homeostasis being challenged, with biological consequences that can cause cardiovascular diseases (CVD). Stressors may be diverse and include a variety of psychological stressors, such as family stress, job strain, effort-award imbalance, long working hours, insecurity, social isolation, and lack of purpose in life. However, stressors may also be physical, immunological, metabolic, or environmental. Type of personality, anxiety, depression, pessimism or hostility, previous experience, genomics, body composition, nutritive and training status modulate stress responses and are important co-stressors. Chronic stress is linked with altered neurohormonal activity, which increases apoptotic pathways in cardiomyocytes. These pathways contribute to impaired myocardial contractility, increased risk of myocardial ischemia, infarction, heart failure, and arrhythmias. While stress is a vital risk factor for CVD, it has not been a major focus of preventive strategies. The purpose of this article is to review the impact of stress on CVD risk with an emphasis on approaches for stress reduction. Strength and endurance exercise, although being stress itself, leads to better adaptiveness to other types of stress, and by far has played an inevitable role in CVD risk reduction. Innovative strategies to combat CVD are strongly needed and exercise may be the best population-level cost-effective approach.",
publisher = "Wolters Kluwer Medknow Publications",
journal = "Heart and Mind",
title = "Stress, cardiovascular diseases and exercise - A narrative review",
volume = "7",
number = "1",
pages = "18-24",
doi = "10.4103/hm.hm_33_22"
}

Popović, D.,& Lavie, C.. (2023). Stress, cardiovascular diseases and exercise - A narrative review. in Heart and Mind
Wolters Kluwer Medknow Publications., 7(1), 18-24.
https://doi.org/10.4103/hm.hm_33_22

Popović D, Lavie C. Stress, cardiovascular diseases and exercise - A narrative review. in Heart and Mind. 2023;7(1):18-24.
doi:10.4103/hm.hm_33_22 .

Popović, Dejana, Lavie, Carl, "Stress, cardiovascular diseases and exercise - A narrative review" in Heart and Mind, 7, no. 1 (2023):18-24,
https://doi.org/10.4103/hm.hm_33_22 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Bjelobrk, Marija
AU  - Tesić, Milorad
AU  - Seman, Stefan
AU  - Jayasinghe, Sisitha
AU  - Hills, Andrew
AU  - Samuel Babu, Abraham
AU  - Jakovljević, Đorđe.
AU  - Stoner, Lee
AU  - Ozemek, Cemal
AU  - Bond, Samantha
AU  - Faghy, Mark
AU  - Pronk, Nicolaas
AU  - Lavie, Carl
AU  - Arena, Ross
AU  - On behalf of the HL - PIVOT Network
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4064
AB  - Traditional risk factors for cardiovascular disease (CVD) have long been the focus of preventive strategies. The impact of family stress, depression, anxiety, hostility, pessimism, job strain, social isolation, lack of purpose in life and social support, are well recognized risks for CVD development, however they are under-appreciated in clinical practice guidelines. The purpose of this article is to review the impact of acute and chronic stress on CVD risk, elaborate repositioning in guidelines, with emphasis to approaches for stress reduction. Regular exercise, both aerobic and resistance, leads to better adaptiveness to other types of stress, however, it remains unknown whether the total amount of stress one can receive before negative health effects is unlimited. Evidently, marked reductions in stress related disorders are shown following formal cardiac rehabilitation programs. Attendance of cardiac rehabilitation is highly recommended for the stress-related mortality risk reduction. Innovative approaches to offset the broad challenges that CVD pose, augmented by sustained exposure to stress, are desperately needed, but hindered by a lack of successful population-level interventions that promote lasting change.
PB  - W.B. Saunders
T2  - Progress in Cardiovascular Diseases
T1  - Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise
DO  - 10.1016/j.pcad.2022.01.008
ER  - 

@article{
author = "Popović, Dejana and Bjelobrk, Marija and Tesić, Milorad and Seman, Stefan and Jayasinghe, Sisitha and Hills, Andrew and Samuel Babu, Abraham and Jakovljević, Đorđe. and Stoner, Lee and Ozemek, Cemal and Bond, Samantha and Faghy, Mark and Pronk, Nicolaas and Lavie, Carl and Arena, Ross and On behalf of the HL - PIVOT Network",
year = "2022",
abstract = "Traditional risk factors for cardiovascular disease (CVD) have long been the focus of preventive strategies. The impact of family stress, depression, anxiety, hostility, pessimism, job strain, social isolation, lack of purpose in life and social support, are well recognized risks for CVD development, however they are under-appreciated in clinical practice guidelines. The purpose of this article is to review the impact of acute and chronic stress on CVD risk, elaborate repositioning in guidelines, with emphasis to approaches for stress reduction. Regular exercise, both aerobic and resistance, leads to better adaptiveness to other types of stress, however, it remains unknown whether the total amount of stress one can receive before negative health effects is unlimited. Evidently, marked reductions in stress related disorders are shown following formal cardiac rehabilitation programs. Attendance of cardiac rehabilitation is highly recommended for the stress-related mortality risk reduction. Innovative approaches to offset the broad challenges that CVD pose, augmented by sustained exposure to stress, are desperately needed, but hindered by a lack of successful population-level interventions that promote lasting change.",
publisher = "W.B. Saunders",
journal = "Progress in Cardiovascular Diseases",
title = "Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise",
doi = "10.1016/j.pcad.2022.01.008"
}

Popović, D., Bjelobrk, M., Tesić, M., Seman, S., Jayasinghe, S., Hills, A., Samuel Babu, A., Jakovljević, Đorđe., Stoner, L., Ozemek, C., Bond, S., Faghy, M., Pronk, N., Lavie, C., Arena, R.,& On behalf of the HL - PIVOT Network. (2022). Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise. in Progress in Cardiovascular Diseases
W.B. Saunders..
https://doi.org/10.1016/j.pcad.2022.01.008

Popović D, Bjelobrk M, Tesić M, Seman S, Jayasinghe S, Hills A, Samuel Babu A, Jakovljević Đ, Stoner L, Ozemek C, Bond S, Faghy M, Pronk N, Lavie C, Arena R, On behalf of the HL - PIVOT Network. Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise. in Progress in Cardiovascular Diseases. 2022;.
doi:10.1016/j.pcad.2022.01.008 .

Popović, Dejana, Bjelobrk, Marija, Tesić, Milorad, Seman, Stefan, Jayasinghe, Sisitha, Hills, Andrew, Samuel Babu, Abraham, Jakovljević, Đorđe., Stoner, Lee, Ozemek, Cemal, Bond, Samantha, Faghy, Mark, Pronk, Nicolaas, Lavie, Carl, Arena, Ross, On behalf of the HL - PIVOT Network, "Defining the importance of stress reduction in managing cardiovascular disease - the role of exercise" in Progress in Cardiovascular Diseases (2022),
https://doi.org/10.1016/j.pcad.2022.01.008 . .

TY  - JOUR
AU  - Taylor, Jenna
AU  - Popović, Dejana
AU  - Lavie, Carl
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4251
PB  - Elsevier Inc.
T2  - Canadian Journal of CardiologyOpen Access
T1  - Exercise Modalities and Intensity to Improve Functional Capacity and Psychological/Mental Health in Cardiac Rehabilitation: A Role for Nordic Walking?
VL  - 38
IS  - 8
SP  - 1135
EP  - 1137
DO  - 10.1016/j.cjca.2022.03.020
ER  - 

@article{
author = "Taylor, Jenna and Popović, Dejana and Lavie, Carl",
year = "2022",
publisher = "Elsevier Inc.",
journal = "Canadian Journal of CardiologyOpen Access",
title = "Exercise Modalities and Intensity to Improve Functional Capacity and Psychological/Mental Health in Cardiac Rehabilitation: A Role for Nordic Walking?",
volume = "38",
number = "8",
pages = "1135-1137",
doi = "10.1016/j.cjca.2022.03.020"
}

Taylor, J., Popović, D.,& Lavie, C.. (2022). Exercise Modalities and Intensity to Improve Functional Capacity and Psychological/Mental Health in Cardiac Rehabilitation: A Role for Nordic Walking?. in Canadian Journal of CardiologyOpen Access
Elsevier Inc.., 38(8), 1135-1137.
https://doi.org/10.1016/j.cjca.2022.03.020

Taylor J, Popović D, Lavie C. Exercise Modalities and Intensity to Improve Functional Capacity and Psychological/Mental Health in Cardiac Rehabilitation: A Role for Nordic Walking?. in Canadian Journal of CardiologyOpen Access. 2022;38(8):1135-1137.
doi:10.1016/j.cjca.2022.03.020 .

Taylor, Jenna, Popović, Dejana, Lavie, Carl, "Exercise Modalities and Intensity to Improve Functional Capacity and Psychological/Mental Health in Cardiac Rehabilitation: A Role for Nordic Walking?" in Canadian Journal of CardiologyOpen Access, 38, no. 8 (2022):1135-1137,
https://doi.org/10.1016/j.cjca.2022.03.020 . .

TY  - JOUR
AU  - Ozemek, Cemal
AU  - Phillips, Shane A.
AU  - Popović, Dejana
AU  - Laddu-Patel, Deepika
AU  - Fancher, Ibra S.
AU  - Arena, Ross
AU  - Lavie, Carl J.
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2911
AB  - Purpose of reviewNonpharmacologic lifestyle modification interventions (LMIs), such as increasing physical activity, dietary modification, weight-loss, reducing alcohol consumption and smoking cessation, are effective strategies to lower resting blood pressures (BPs) in prehypertensive or hypertensive patients. However, the limited time shared between a physician and a patient is not adequate to instill an adoption of LMI. The purpose of this review is to therefore highlight evidence-based BP lowering, LMI strategies that can feasibly be implemented in clinical practices.Recent findingsInterventions focusing on modifying physical activity, diet, weight-loss, drinking and smoking habits have established greater efficacy in reducing elevated BP compared with providing guideline recommendations based on national guidelines. Alone greater reductions in BP can be achieved through programmes that provide frequent contact time with exercise, nutrition and/or wellness professionals. Programmes that educate individuals to lead peer support groups can be an efficient method of ensuring compliance to LMI.SummaryEvidence of a multidisciplinary approach to LMI is an effective and attractive model in managing elevated BP. This strategy is an attractive model that provides the necessary patient attention to confer lifestyle maintenance.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - Current Opinion in Cardiology
T1  - Nonpharmacologic management of hypertension: a multidisciplinary approach
VL  - 32
IS  - 4
SP  - 381
EP  - 388
DO  - 10.1097/HCO.0000000000000406
ER  - 

@article{
author = "Ozemek, Cemal and Phillips, Shane A. and Popović, Dejana and Laddu-Patel, Deepika and Fancher, Ibra S. and Arena, Ross and Lavie, Carl J.",
year = "2017",
abstract = "Purpose of reviewNonpharmacologic lifestyle modification interventions (LMIs), such as increasing physical activity, dietary modification, weight-loss, reducing alcohol consumption and smoking cessation, are effective strategies to lower resting blood pressures (BPs) in prehypertensive or hypertensive patients. However, the limited time shared between a physician and a patient is not adequate to instill an adoption of LMI. The purpose of this review is to therefore highlight evidence-based BP lowering, LMI strategies that can feasibly be implemented in clinical practices.Recent findingsInterventions focusing on modifying physical activity, diet, weight-loss, drinking and smoking habits have established greater efficacy in reducing elevated BP compared with providing guideline recommendations based on national guidelines. Alone greater reductions in BP can be achieved through programmes that provide frequent contact time with exercise, nutrition and/or wellness professionals. Programmes that educate individuals to lead peer support groups can be an efficient method of ensuring compliance to LMI.SummaryEvidence of a multidisciplinary approach to LMI is an effective and attractive model in managing elevated BP. This strategy is an attractive model that provides the necessary patient attention to confer lifestyle maintenance.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "Current Opinion in Cardiology",
title = "Nonpharmacologic management of hypertension: a multidisciplinary approach",
volume = "32",
number = "4",
pages = "381-388",
doi = "10.1097/HCO.0000000000000406"
}

Ozemek, C., Phillips, S. A., Popović, D., Laddu-Patel, D., Fancher, I. S., Arena, R.,& Lavie, C. J.. (2017). Nonpharmacologic management of hypertension: a multidisciplinary approach. in Current Opinion in Cardiology
Lippincott Williams & Wilkins, Philadelphia., 32(4), 381-388.
https://doi.org/10.1097/HCO.0000000000000406

Ozemek C, Phillips SA, Popović D, Laddu-Patel D, Fancher IS, Arena R, Lavie CJ. Nonpharmacologic management of hypertension: a multidisciplinary approach. in Current Opinion in Cardiology. 2017;32(4):381-388.
doi:10.1097/HCO.0000000000000406 .

Ozemek, Cemal, Phillips, Shane A., Popović, Dejana, Laddu-Patel, Deepika, Fancher, Ibra S., Arena, Ross, Lavie, Carl J., "Nonpharmacologic management of hypertension: a multidisciplinary approach" in Current Opinion in Cardiology, 32, no. 4 (2017):381-388,
https://doi.org/10.1097/HCO.0000000000000406 . .

TY  - JOUR
AU  - Carbone, Salvatore
AU  - Popović, Dejana
AU  - Lavie, Carl J.
AU  - Arena, Ross
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2854
AB  - Obesity is defined as an excess body fat that impairs health and is associated with increased risk of heart failure (HF), particularly HF with preserved ejection fraction (HFpEF), evolving into a 'HFpEF obesity phenotype'. The interplay between obesity and cardiorespiratory fitness, primary clinical parameters in HF, requires further exploration. The contribution of body composition compartments in the development and progress of HF has been the object of numerous studies. Here we focus on how fat mass and lean tissues affect cardiorespiratory fitness, with emphasis on their effects on peak oxygen consumption. Moreover, while several studies have focused on characterization of body composition compartments, here we describe also recent findings related to abnormal and/or dysfunctional lean mass, especially in HFpEF.
PB  - Future Medicine Ltd, London
T2  - Future Cardiology
T1  - Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction
VL  - 13
IS  - 5
SP  - 451
EP  - 463
DO  - 10.2217/fca-2017-0023
ER  - 

@article{
author = "Carbone, Salvatore and Popović, Dejana and Lavie, Carl J. and Arena, Ross",
year = "2017",
abstract = "Obesity is defined as an excess body fat that impairs health and is associated with increased risk of heart failure (HF), particularly HF with preserved ejection fraction (HFpEF), evolving into a 'HFpEF obesity phenotype'. The interplay between obesity and cardiorespiratory fitness, primary clinical parameters in HF, requires further exploration. The contribution of body composition compartments in the development and progress of HF has been the object of numerous studies. Here we focus on how fat mass and lean tissues affect cardiorespiratory fitness, with emphasis on their effects on peak oxygen consumption. Moreover, while several studies have focused on characterization of body composition compartments, here we describe also recent findings related to abnormal and/or dysfunctional lean mass, especially in HFpEF.",
publisher = "Future Medicine Ltd, London",
journal = "Future Cardiology",
title = "Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction",
volume = "13",
number = "5",
pages = "451-463",
doi = "10.2217/fca-2017-0023"
}

Carbone, S., Popović, D., Lavie, C. J.,& Arena, R.. (2017). Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction. in Future Cardiology
Future Medicine Ltd, London., 13(5), 451-463.
https://doi.org/10.2217/fca-2017-0023

Carbone S, Popović D, Lavie CJ, Arena R. Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction. in Future Cardiology. 2017;13(5):451-463.
doi:10.2217/fca-2017-0023 .

Carbone, Salvatore, Popović, Dejana, Lavie, Carl J., Arena, Ross, "Obesity, body composition and cardiorespiratory fitness in heart failure with preserved ejection fraction" in Future Cardiology, 13, no. 5 (2017):451-463,
https://doi.org/10.2217/fca-2017-0023 . .

TY  - JOUR
AU  - Parto, Parham
AU  - Lavie, Carl J.
AU  - Arena, Ross
AU  - Bond, Samantha
AU  - Popović, Dejana
AU  - Ventura, Hector O.
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2757
AB  - The prevalence of obesity among adults and children worldwide has reached epic proportions and has become a major independent risk factor for the development of heart failure (HF), in addition to a contributor of hypertension and cardiovascular disease. The implications of obesity in the development of HF involve adverse effects on cardiac structure and function. Despite all of this, in the setting of chronic HF, excess body mass is associated with improved clinical outcomes, demonstrating the presence of an obesity paradox. In this review, we will discuss the gender differences, global application, potential mechanisms and role of interventions based on fitness and purposeful weight loss as potential therapeutic strategies.
PB  - Future Medicine Ltd, London
T2  - Future Cardiology
T1  - Body habitus in heart failure: understanding the mechanisms and clinical significance of the obesity paradox
VL  - 12
IS  - 6
SP  - 639
EP  - 653
DO  - 10.2217/fca-2016-0029
ER  - 

@article{
author = "Parto, Parham and Lavie, Carl J. and Arena, Ross and Bond, Samantha and Popović, Dejana and Ventura, Hector O.",
year = "2016",
abstract = "The prevalence of obesity among adults and children worldwide has reached epic proportions and has become a major independent risk factor for the development of heart failure (HF), in addition to a contributor of hypertension and cardiovascular disease. The implications of obesity in the development of HF involve adverse effects on cardiac structure and function. Despite all of this, in the setting of chronic HF, excess body mass is associated with improved clinical outcomes, demonstrating the presence of an obesity paradox. In this review, we will discuss the gender differences, global application, potential mechanisms and role of interventions based on fitness and purposeful weight loss as potential therapeutic strategies.",
publisher = "Future Medicine Ltd, London",
journal = "Future Cardiology",
title = "Body habitus in heart failure: understanding the mechanisms and clinical significance of the obesity paradox",
volume = "12",
number = "6",
pages = "639-653",
doi = "10.2217/fca-2016-0029"
}

Parto, P., Lavie, C. J., Arena, R., Bond, S., Popović, D.,& Ventura, H. O.. (2016). Body habitus in heart failure: understanding the mechanisms and clinical significance of the obesity paradox. in Future Cardiology
Future Medicine Ltd, London., 12(6), 639-653.
https://doi.org/10.2217/fca-2016-0029

Parto P, Lavie CJ, Arena R, Bond S, Popović D, Ventura HO. Body habitus in heart failure: understanding the mechanisms and clinical significance of the obesity paradox. in Future Cardiology. 2016;12(6):639-653.
doi:10.2217/fca-2016-0029 .

Parto, Parham, Lavie, Carl J., Arena, Ross, Bond, Samantha, Popović, Dejana, Ventura, Hector O., "Body habitus in heart failure: understanding the mechanisms and clinical significance of the obesity paradox" in Future Cardiology, 12, no. 6 (2016):639-653,
https://doi.org/10.2217/fca-2016-0029 . .