TY  - JOUR
AU  - Ilić, V
AU  - Bogićević, Dragana
AU  - Miljković, Branislava
AU  - Ješić, M
AU  - Kovačević, M
AU  - Prostran, Milica
AU  - Vezmar-Kovačević, Sandra
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2767
AB  - Aim. To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Methods. Serumlevels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- And age-matched healthy children. Results. Meanvalproic acid treatment durationwas 2.80?}1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p lt 0.001) and free triiodothyronine (p lt 0.05) levels compared to the control group. Serum thyroid-stimulating hormone and free triiodothyronine were above the upper limit for healthy controls in 34% and 32% of patients, respectively, and no clinical features of thyroid dysfunction were observed. Duration of valproic acid monotherapy for less than four years was a risk factor for elevated thyroid-stimulating hormone levels. Conclusion. One third of children with normal range serum valproic acid levels may have elevated serum thyroid-stimulating hormone and free triiodothyronine levels, especially in the first four years of treatment.
PB  - John Libbey Eurotext
T2  - Epileptic Disorders
T1  - Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy
VL  - 18
IS  - 2
SP  - 181
EP  - 186
DO  - 10.1684/epd.2016.0821
ER  - 

@article{
author = "Ilić, V and Bogićević, Dragana and Miljković, Branislava and Ješić, M and Kovačević, M and Prostran, Milica and Vezmar-Kovačević, Sandra",
year = "2016",
abstract = "Aim. To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Methods. Serumlevels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- And age-matched healthy children. Results. Meanvalproic acid treatment durationwas 2.80?}1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p lt 0.001) and free triiodothyronine (p lt 0.05) levels compared to the control group. Serum thyroid-stimulating hormone and free triiodothyronine were above the upper limit for healthy controls in 34% and 32% of patients, respectively, and no clinical features of thyroid dysfunction were observed. Duration of valproic acid monotherapy for less than four years was a risk factor for elevated thyroid-stimulating hormone levels. Conclusion. One third of children with normal range serum valproic acid levels may have elevated serum thyroid-stimulating hormone and free triiodothyronine levels, especially in the first four years of treatment.",
publisher = "John Libbey Eurotext",
journal = "Epileptic Disorders",
title = "Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy",
volume = "18",
number = "2",
pages = "181-186",
doi = "10.1684/epd.2016.0821"
}

Ilić, V., Bogićević, D., Miljković, B., Ješić, M., Kovačević, M., Prostran, M.,& Vezmar-Kovačević, S.. (2016). Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy. in Epileptic Disorders
John Libbey Eurotext., 18(2), 181-186.
https://doi.org/10.1684/epd.2016.0821

Ilić V, Bogićević D, Miljković B, Ješić M, Kovačević M, Prostran M, Vezmar-Kovačević S. Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy. in Epileptic Disorders. 2016;18(2):181-186.
doi:10.1684/epd.2016.0821 .

Ilić, V, Bogićević, Dragana, Miljković, Branislava, Ješić, M, Kovačević, M, Prostran, Milica, Vezmar-Kovačević, Sandra, "Duration of valproic acid monotherapy correlates with subclinical thyroid dysfunction in children with epilepsy" in Epileptic Disorders, 18, no. 2 (2016):181-186,
https://doi.org/10.1684/epd.2016.0821 . .