TY  - JOUR
AU  - Vezmar-Kovačević, Sandra
AU  - Simisić, Mika
AU  - Stojkov-Rudinski, Svetlana
AU  - Ćulafić, Milica
AU  - Vučićević, Katarina
AU  - Prostran, Milica
AU  - Miljković, Branislava
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2227
AB  - Objectives: The aim of the study was to determine the rate of Potentially Inappropriate Medicines (PIM) and Potential Prescription Omissions (PPO) according to Screening Tool of Older Person's potentially inappropriate Prescriptions/Screening Tool to Alert doctors to the Right Treatment (STOPP/START) criteria. Study Design: A cross-sectional survey in community pharmacy. Method: A prospective cross-sectional study was performed, during March-May 2012, in five community pharmacies. Patients aged >= 65 years, who collected one or more prescribed medications, were asked to participate in the study, and an interview was scheduled. Patients were asked to provide their complete medical and biochemical record from their general practitioner. Results: 509 patients, mean age 74.8 +/- 6.5 years, 57.4% female, participated in the study. 164 PIM were identified in 139 patients (27.3%). The most common were: long-term use of long-acting benzodiazepines (20.7%), use of non-steroidal antiinflammatory drugs (NSAID) in patients with moderate-severe hypertension (20.1%), use of theophylline as monotherapy for chronic obstructive pulmonary disease (COPD, 15.9%) and use of aspirin without appropriate indication (15.2%). Patients with more than four prescpritions had a higher risk for PIM (OR 2.85, 95% CI 1.97-4.14, p lt 0.001). There were 439 PPO, identified in 257, (50.5%) patients. Predictors for PPO were older age, presence of diabetes, myocardial infarction, osteoporosis, stroke, COPD and/or angina pectoris. Conclusion: STOPP/START criteria may be useful in identifying inappropriate prescribing and improving the current prescribing practices. Pharmacists should focus more on patients with more than four medications and/or patients with gout or pain accompanied with arterial hypertension because those patient may be at higher risk of PIM. Additionlly, patients older than 74 years with diabetes, osteoporosis, myocardial infarction, stroke, angina pectoris and/or COPD may have an increased risk of PPO.
PB  - Public Library Science, San Francisco
T2  - PLoS One
T1  - Potentially Inappropriate Prescribing in Older Primary Care Patients
VL  - 9
IS  - 4
DO  - 10.1371/journal.pone.0095536
ER  - 

@article{
author = "Vezmar-Kovačević, Sandra and Simisić, Mika and Stojkov-Rudinski, Svetlana and Ćulafić, Milica and Vučićević, Katarina and Prostran, Milica and Miljković, Branislava",
year = "2014",
abstract = "Objectives: The aim of the study was to determine the rate of Potentially Inappropriate Medicines (PIM) and Potential Prescription Omissions (PPO) according to Screening Tool of Older Person's potentially inappropriate Prescriptions/Screening Tool to Alert doctors to the Right Treatment (STOPP/START) criteria. Study Design: A cross-sectional survey in community pharmacy. Method: A prospective cross-sectional study was performed, during March-May 2012, in five community pharmacies. Patients aged >= 65 years, who collected one or more prescribed medications, were asked to participate in the study, and an interview was scheduled. Patients were asked to provide their complete medical and biochemical record from their general practitioner. Results: 509 patients, mean age 74.8 +/- 6.5 years, 57.4% female, participated in the study. 164 PIM were identified in 139 patients (27.3%). The most common were: long-term use of long-acting benzodiazepines (20.7%), use of non-steroidal antiinflammatory drugs (NSAID) in patients with moderate-severe hypertension (20.1%), use of theophylline as monotherapy for chronic obstructive pulmonary disease (COPD, 15.9%) and use of aspirin without appropriate indication (15.2%). Patients with more than four prescpritions had a higher risk for PIM (OR 2.85, 95% CI 1.97-4.14, p lt 0.001). There were 439 PPO, identified in 257, (50.5%) patients. Predictors for PPO were older age, presence of diabetes, myocardial infarction, osteoporosis, stroke, COPD and/or angina pectoris. Conclusion: STOPP/START criteria may be useful in identifying inappropriate prescribing and improving the current prescribing practices. Pharmacists should focus more on patients with more than four medications and/or patients with gout or pain accompanied with arterial hypertension because those patient may be at higher risk of PIM. Additionlly, patients older than 74 years with diabetes, osteoporosis, myocardial infarction, stroke, angina pectoris and/or COPD may have an increased risk of PPO.",
publisher = "Public Library Science, San Francisco",
journal = "PLoS One",
title = "Potentially Inappropriate Prescribing in Older Primary Care Patients",
volume = "9",
number = "4",
doi = "10.1371/journal.pone.0095536"
}

Vezmar-Kovačević, S., Simisić, M., Stojkov-Rudinski, S., Ćulafić, M., Vučićević, K., Prostran, M.,& Miljković, B.. (2014). Potentially Inappropriate Prescribing in Older Primary Care Patients. in PLoS One
Public Library Science, San Francisco., 9(4).
https://doi.org/10.1371/journal.pone.0095536

Vezmar-Kovačević S, Simisić M, Stojkov-Rudinski S, Ćulafić M, Vučićević K, Prostran M, Miljković B. Potentially Inappropriate Prescribing in Older Primary Care Patients. in PLoS One. 2014;9(4).
doi:10.1371/journal.pone.0095536 .

Vezmar-Kovačević, Sandra, Simisić, Mika, Stojkov-Rudinski, Svetlana, Ćulafić, Milica, Vučićević, Katarina, Prostran, Milica, Miljković, Branislava, "Potentially Inappropriate Prescribing in Older Primary Care Patients" in PLoS One, 9, no. 4 (2014),
https://doi.org/10.1371/journal.pone.0095536 . .