TY  - JOUR
AU  - Dobričić, Vladimir
AU  - Stanišić, Aleksa
AU  - Vladimirov, Sote
AU  - Čudina, Olivera
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3209
AB  - Octanol-water partition coefficients (log Po/w) of fifteen previously synthesized 17 beta-carboxamide glucocorticoid derivatives and prednisolone were determined using shake-flask method. The retention behavior of selected compounds was tested in five reversed-phased thin-layer chromatography (RP-TLC) systems, consisting of water and organic solvent (acetonitrile, acetone, ethanol 96%, methanol, or tetrahydrofuran), and chromatography parameters (R-M(0), S, and C-0) were calculated. Simple linear regression (SLR) analysis was performed, and the correlation between log Po/w and chromatography parameters was tested. The most appropriate RP-TLC system for log Po/w prediction was that consisting of water and ethanol 96% as the mobile phase. Statisitical evaluation of the quality of models created using this system proved their reliability for log Po/w prediction of new 17 beta-carboxamide glucocorticoid derivatives, and the model with the most favorable statistical parameters was underlined.
PB  - Akademiai Kiado Zrt, Budapest
T2  - Journal of Planar Chromatography - Modern TLC
T1  - Development of a Reversed-Phased Thin-Layer
Chromatography Method for the Lipophilicity Prediction of
17β-Carboxamide Glucocorticoid Derivatives
VL  - 31
IS  - 3
SP  - 250
EP  - 256
DO  - 10.1556/1006.2018.31.3.11
ER  - 

@article{
author = "Dobričić, Vladimir and Stanišić, Aleksa and Vladimirov, Sote and Čudina, Olivera",
year = "2018",
abstract = "Octanol-water partition coefficients (log Po/w) of fifteen previously synthesized 17 beta-carboxamide glucocorticoid derivatives and prednisolone were determined using shake-flask method. The retention behavior of selected compounds was tested in five reversed-phased thin-layer chromatography (RP-TLC) systems, consisting of water and organic solvent (acetonitrile, acetone, ethanol 96%, methanol, or tetrahydrofuran), and chromatography parameters (R-M(0), S, and C-0) were calculated. Simple linear regression (SLR) analysis was performed, and the correlation between log Po/w and chromatography parameters was tested. The most appropriate RP-TLC system for log Po/w prediction was that consisting of water and ethanol 96% as the mobile phase. Statisitical evaluation of the quality of models created using this system proved their reliability for log Po/w prediction of new 17 beta-carboxamide glucocorticoid derivatives, and the model with the most favorable statistical parameters was underlined.",
publisher = "Akademiai Kiado Zrt, Budapest",
journal = "Journal of Planar Chromatography - Modern TLC",
title = "Development of a Reversed-Phased Thin-Layer
Chromatography Method for the Lipophilicity Prediction of
17β-Carboxamide Glucocorticoid Derivatives",
volume = "31",
number = "3",
pages = "250-256",
doi = "10.1556/1006.2018.31.3.11"
}

Dobričić, V., Stanišić, A., Vladimirov, S.,& Čudina, O.. (2018). Development of a Reversed-Phased Thin-Layer
Chromatography Method for the Lipophilicity Prediction of
17β-Carboxamide Glucocorticoid Derivatives. in Journal of Planar Chromatography - Modern TLC
Akademiai Kiado Zrt, Budapest., 31(3), 250-256.
https://doi.org/10.1556/1006.2018.31.3.11

Dobričić V, Stanišić A, Vladimirov S, Čudina O. Development of a Reversed-Phased Thin-Layer
Chromatography Method for the Lipophilicity Prediction of
17β-Carboxamide Glucocorticoid Derivatives. in Journal of Planar Chromatography - Modern TLC. 2018;31(3):250-256.
doi:10.1556/1006.2018.31.3.11 .

Dobričić, Vladimir, Stanišić, Aleksa, Vladimirov, Sote, Čudina, Olivera, "Development of a Reversed-Phased Thin-Layer
Chromatography Method for the Lipophilicity Prediction of
17β-Carboxamide Glucocorticoid Derivatives" in Journal of Planar Chromatography - Modern TLC, 31, no. 3 (2018):250-256,
https://doi.org/10.1556/1006.2018.31.3.11 . .