TY  - JOUR
AU  - Koss-Mikołajczyk, Izabela
AU  - Todorović, Vanja
AU  - Šobajić, Slađana
AU  - Mahajna, Jamal
AU  - Gerić, Marko
AU  - Tur, Josep A.
AU  - Bartoszek, Agnieszka
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3971
AB  - Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent.
PB  - MDPI
T2  - International Journal of Molecular Sciences
T1  - Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review
VL  - 22
IS  - 18
DO  - 10.3390/ijms221810037
ER  - 

@article{
author = "Koss-Mikołajczyk, Izabela and Todorović, Vanja and Šobajić, Slađana and Mahajna, Jamal and Gerić, Marko and Tur, Josep A. and Bartoszek, Agnieszka",
year = "2021",
abstract = "Cardiotoxicity is a frequent undesirable phenomenon observed during oncological treatment that limits the therapeutic dose of antitumor drugs and thus may decrease the effectiveness of cancer eradication. Almost all antitumor drugs exhibit toxic properties towards cardiac muscle. One of the underlying causes of cardiotoxicity is the stimulation of oxidative stress by chemotherapy. This suggests that an appropriately designed diet or dietary supplements based on edible plants rich in antioxidants could decrease the toxicity of antitumor drugs and diminish the risk of cardiac failure. This comprehensive review compares the cardioprotective efficacy of edible plant extracts and foodborne phytochemicals whose beneficial activity was demonstrated in various models in vivo and in vitro. The studies selected for this review concentrated on a therapy frequently applied in cancer, anthracycline antibiotic—doxorubicin—as the oxidative stress- and cardiotoxicity-inducing agent.",
publisher = "MDPI",
journal = "International Journal of Molecular Sciences",
title = "Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review",
volume = "22",
number = "18",
doi = "10.3390/ijms221810037"
}

Koss-Mikołajczyk, I., Todorović, V., Šobajić, S., Mahajna, J., Gerić, M., Tur, J. A.,& Bartoszek, A.. (2021). Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review. in International Journal of Molecular Sciences
MDPI., 22(18).
https://doi.org/10.3390/ijms221810037

Koss-Mikołajczyk I, Todorović V, Šobajić S, Mahajna J, Gerić M, Tur JA, Bartoszek A. Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review. in International Journal of Molecular Sciences. 2021;22(18).
doi:10.3390/ijms221810037 .

Koss-Mikołajczyk, Izabela, Todorović, Vanja, Šobajić, Slađana, Mahajna, Jamal, Gerić, Marko, Tur, Josep A., Bartoszek, Agnieszka, "Natural products counteracting cardiotoxicity during cancer chemotherapy: The special case of doxorubicin, a comprehensive review" in International Journal of Molecular Sciences, 22, no. 18 (2021),
https://doi.org/10.3390/ijms221810037 . .

TY  - JOUR
AU  - Baranowska, Monika
AU  - Suliborska, Klaudia
AU  - Todorović, Vanja
AU  - Kusznierewicz, Barbara
AU  - Chrzanowski, Wojciech
AU  - Šobajić, Slađana
AU  - Bartoszek, Agnieszka
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3584
AB  - Numerous studies have shown, rather disappointingly, that isolated bioactive phytochemicals are not as biologically effective as natural plant products. Such a discrepancy may be explained by the concept of food synergy, which was verified in this research for cocoa extract versus its major components with regard to cancer chemoprevention. The evaluation embraced the relationship between redox properties evaluated in cell-free systems with the aid of free radicals scavenging method and differential pulse voltammetry, and redox associated anticarcinogenic activities (cellular antioxidant activity, cytotoxicity, nutrigenomic activity) in human colon adenocarcinoma cell line exposed to either cocoa powder extract or artificial mixtures of cocoa bioactives at matching concentrations. In contrast to expectations, our results showed that the stepwise enrichment with antioxidants caused no gradual increase in the antioxidant activity of the model mixtures; also, these model mixtures did not reach the reducing potential of cocoa in the cell-free systems or cellular model employed. Further, the biological activities examined in colon adenocarcinoma cells did not alter in a stepwise manner that could reflect the gradual changes in composition of bioactive ingredients. In conclusion, the experiments presented here showed that the growing complexity of a mixture of phytochemicals seems to create a new redox bioactive substance rather than enrich the mixture with new activities, characteristic of the compound added. It follows that no simple, predictable relationship can be expected between the chemopreventive potential and the composition of real food items containing a complicated set of non-toxic redox active ingredients. Our observations suggest that the interactions between different bioactive compounds and food matrix components are cooperating factors determining the final bioactivity of foods.
PB  - Elsevier
T2  - Free Radical Biology and Medicine
T1  - Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract
VL  - 154
SP  - 48
EP  - 61
DO  - 10.1016/j.freeradbiomed.2020.04.022
ER  - 

@article{
author = "Baranowska, Monika and Suliborska, Klaudia and Todorović, Vanja and Kusznierewicz, Barbara and Chrzanowski, Wojciech and Šobajić, Slađana and Bartoszek, Agnieszka",
year = "2020",
abstract = "Numerous studies have shown, rather disappointingly, that isolated bioactive phytochemicals are not as biologically effective as natural plant products. Such a discrepancy may be explained by the concept of food synergy, which was verified in this research for cocoa extract versus its major components with regard to cancer chemoprevention. The evaluation embraced the relationship between redox properties evaluated in cell-free systems with the aid of free radicals scavenging method and differential pulse voltammetry, and redox associated anticarcinogenic activities (cellular antioxidant activity, cytotoxicity, nutrigenomic activity) in human colon adenocarcinoma cell line exposed to either cocoa powder extract or artificial mixtures of cocoa bioactives at matching concentrations. In contrast to expectations, our results showed that the stepwise enrichment with antioxidants caused no gradual increase in the antioxidant activity of the model mixtures; also, these model mixtures did not reach the reducing potential of cocoa in the cell-free systems or cellular model employed. Further, the biological activities examined in colon adenocarcinoma cells did not alter in a stepwise manner that could reflect the gradual changes in composition of bioactive ingredients. In conclusion, the experiments presented here showed that the growing complexity of a mixture of phytochemicals seems to create a new redox bioactive substance rather than enrich the mixture with new activities, characteristic of the compound added. It follows that no simple, predictable relationship can be expected between the chemopreventive potential and the composition of real food items containing a complicated set of non-toxic redox active ingredients. Our observations suggest that the interactions between different bioactive compounds and food matrix components are cooperating factors determining the final bioactivity of foods.",
publisher = "Elsevier",
journal = "Free Radical Biology and Medicine",
title = "Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract",
volume = "154",
pages = "48-61",
doi = "10.1016/j.freeradbiomed.2020.04.022"
}

Baranowska, M., Suliborska, K., Todorović, V., Kusznierewicz, B., Chrzanowski, W., Šobajić, S.,& Bartoszek, A.. (2020). Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract. in Free Radical Biology and Medicine
Elsevier., 154, 48-61.
https://doi.org/10.1016/j.freeradbiomed.2020.04.022

Baranowska M, Suliborska K, Todorović V, Kusznierewicz B, Chrzanowski W, Šobajić S, Bartoszek A. Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract. in Free Radical Biology and Medicine. 2020;154:48-61.
doi:10.1016/j.freeradbiomed.2020.04.022 .

Baranowska, Monika, Suliborska, Klaudia, Todorović, Vanja, Kusznierewicz, Barbara, Chrzanowski, Wojciech, Šobajić, Slađana, Bartoszek, Agnieszka, "Interactions between bioactive components determine antioxidant, cytotoxic and nutrigenomic activity of cocoa powder extract" in Free Radical Biology and Medicine, 154 (2020):48-61,
https://doi.org/10.1016/j.freeradbiomed.2020.04.022 . .