Larsen, Anders Rhod

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  • Larsen, Anders Rhod (2)
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Author's Bibliography

Methicillin-resistant Staphylococcus aureus biofilm formation on dacryocystorhinostomy silicone tubes depends on the genetic lineage

Cirković, Ivana; Knežević, Miroslav; Božić, Dragana; Rasić, Dejan; Larsen, Anders Rhod; Dukić, Slobodanka

(Springer, New York, 2015) 

TY  - JOUR
AU  - Cirković, Ivana
AU  - Knežević, Miroslav
AU  - Božić, Dragana
AU  - Rasić, Dejan
AU  - Larsen, Anders Rhod
AU  - Dukić, Slobodanka
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2414
AB  - The aim of this study was to investigate biofilm formation on silicone tubes by genetically diverse methicillin-resistant Staphylococcus aureus (MRSA) strains. Capacity of biofilm formation on dacryocystorhinostomy silicone tubes was tested on 30 MRSA strains. Identification and methicillin resistance were confirmed by PCR for nuc and mecA genes. Strains were genotypically characterised (SCCmec, agr and spa typing). Biofilm formation was tested in microtiter plate and on silicone tubes. Tested MRSA strains were classified into SCCmec type I (33.3 %), II (3.3 %), III (20.0 %), IV (26.7 %) and V (16.7 %), agr type I (56.7 %), II (36.7 %) and III (6.6 %), and eight spa clonal complexes (CCs). All tested MRSA strains showed ability to form biofilm on microtiter plate. Capacity of biofilm formation on silicone tubes was as follows: 33.3 % of strains belonged to the category of low biofilm producers, and 66.7 % to moderate biofilm producers. There was statistically significant correlation between spa CC and the category of biofilm production on silicone tubes (p = 0.01): CC5 and CC45 with moderate amount of biofilm, and CC8 with low amount of biofilm. A moderate amount of biofilm formed on silicone tubes correlated with agr type II MRSA strains (p = 0.008). Biofilm formation by MRSA on silicone tubes is highly dependent on genetic characteristics of the strains. Therefore, MRSA genotyping may aid the determination of the possibility of biofilm-related ocular device infections. Genotyping and biofilm quantification may be helpful in determining when decolonisation and cohort isolation are required to prevent device-related infections.
PB  - Springer, New York
T2  - Graefes Archive for Clinical and Experimental Ophthalmology
T1  - Methicillin-resistant Staphylococcus aureus biofilm formation on dacryocystorhinostomy silicone tubes depends on the genetic lineage
VL  - 253
IS  - 1
SP  - 77
EP  - 82
DO  - 10.1007/s00417-014-2786-0
ER  - 
@article{
author = "Cirković, Ivana and Knežević, Miroslav and Božić, Dragana and Rasić, Dejan and Larsen, Anders Rhod and Dukić, Slobodanka",
year = "2015",
abstract = "The aim of this study was to investigate biofilm formation on silicone tubes by genetically diverse methicillin-resistant Staphylococcus aureus (MRSA) strains. Capacity of biofilm formation on dacryocystorhinostomy silicone tubes was tested on 30 MRSA strains. Identification and methicillin resistance were confirmed by PCR for nuc and mecA genes. Strains were genotypically characterised (SCCmec, agr and spa typing). Biofilm formation was tested in microtiter plate and on silicone tubes. Tested MRSA strains were classified into SCCmec type I (33.3 %), II (3.3 %), III (20.0 %), IV (26.7 %) and V (16.7 %), agr type I (56.7 %), II (36.7 %) and III (6.6 %), and eight spa clonal complexes (CCs). All tested MRSA strains showed ability to form biofilm on microtiter plate. Capacity of biofilm formation on silicone tubes was as follows: 33.3 % of strains belonged to the category of low biofilm producers, and 66.7 % to moderate biofilm producers. There was statistically significant correlation between spa CC and the category of biofilm production on silicone tubes (p = 0.01): CC5 and CC45 with moderate amount of biofilm, and CC8 with low amount of biofilm. A moderate amount of biofilm formed on silicone tubes correlated with agr type II MRSA strains (p = 0.008). Biofilm formation by MRSA on silicone tubes is highly dependent on genetic characteristics of the strains. Therefore, MRSA genotyping may aid the determination of the possibility of biofilm-related ocular device infections. Genotyping and biofilm quantification may be helpful in determining when decolonisation and cohort isolation are required to prevent device-related infections.",
publisher = "Springer, New York",
journal = "Graefes Archive for Clinical and Experimental Ophthalmology",
title = "Methicillin-resistant Staphylococcus aureus biofilm formation on dacryocystorhinostomy silicone tubes depends on the genetic lineage",
volume = "253",
number = "1",
pages = "77-82",
doi = "10.1007/s00417-014-2786-0"
}
Cirković, I., Knežević, M., Božić, D., Rasić, D., Larsen, A. R.,& Dukić, S.. (2015). Methicillin-resistant Staphylococcus aureus biofilm formation on dacryocystorhinostomy silicone tubes depends on the genetic lineage. in Graefes Archive for Clinical and Experimental Ophthalmology
Springer, New York., 253(1), 77-82.
https://doi.org/10.1007/s00417-014-2786-0
Cirković I, Knežević M, Božić D, Rasić D, Larsen AR, Dukić S. Methicillin-resistant Staphylococcus aureus biofilm formation on dacryocystorhinostomy silicone tubes depends on the genetic lineage. in Graefes Archive for Clinical and Experimental Ophthalmology. 2015;253(1):77-82.
doi:10.1007/s00417-014-2786-0 .
Cirković, Ivana, Knežević, Miroslav, Božić, Dragana, Rasić, Dejan, Larsen, Anders Rhod, Dukić, Slobodanka, "Methicillin-resistant Staphylococcus aureus biofilm formation on dacryocystorhinostomy silicone tubes depends on the genetic lineage" in Graefes Archive for Clinical and Experimental Ophthalmology, 253, no. 1 (2015):77-82,
https://doi.org/10.1007/s00417-014-2786-0 . .
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Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus

Božić, Dragana; Milenković, Marina; Ivković, Branka; Larsen, Anders Rhod; Cirković, Ivana

(Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw, 2015) 

TY  - JOUR
AU  - Božić, Dragana
AU  - Milenković, Marina
AU  - Ivković, Branka
AU  - Larsen, Anders Rhod
AU  - Cirković, Ivana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2374
AB  - Pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) is associated with a broad spectrum of virulence factors, amongst which is a-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)propenone, 3(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on a-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2-1/4 x MIC (25-12.5 mu g/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on a-hemolysin production of multiresistant and genetically diverse MRSA strains.
PB  - Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw
T2  - Polish Journal of Microbiology
T1  - Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus
VL  - 64
IS  - 4
SP  - 379
EP  - 382
DO  - 10.5604/17331331.1185237
ER  - 
@article{
author = "Božić, Dragana and Milenković, Marina and Ivković, Branka and Larsen, Anders Rhod and Cirković, Ivana",
year = "2015",
abstract = "Pathogenicity of methicillin-resistant Staphylococcus aureus (MRSA) is associated with a broad spectrum of virulence factors, amongst which is a-hemolysin. The aim of this study was to investigate the effect of three newly-synthesized chalcones (1,3- Bis-(2-hydroxy-phenyl)propenone, 3(3-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone and 3-(4-Hydroxy-phenyl)-1-(2-hydroxy-phenyl)-propenone) on a-hemolysin production of clinical isolates of MRSA. Subinhibitory concentrations of the tested compounds reduced hemolytic activity of MRSA strains, with almost complete abolishment of hemolysis at concentrations in the range of 1/2-1/4 x MIC (25-12.5 mu g/ml). In conclusion, newly-synthesized chalcones tested in this study showed potent inhibitory activity on a-hemolysin production of multiresistant and genetically diverse MRSA strains.",
publisher = "Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw",
journal = "Polish Journal of Microbiology",
title = "Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus",
volume = "64",
number = "4",
pages = "379-382",
doi = "10.5604/17331331.1185237"
}
Božić, D., Milenković, M., Ivković, B., Larsen, A. R.,& Cirković, I.. (2015). Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus. in Polish Journal of Microbiology
Polskie Towarzystwo Mikrobiologow-Polish Society Of Microbiologists, Warsaw., 64(4), 379-382.
https://doi.org/10.5604/17331331.1185237
Božić D, Milenković M, Ivković B, Larsen AR, Cirković I. Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus. in Polish Journal of Microbiology. 2015;64(4):379-382.
doi:10.5604/17331331.1185237 .
Božić, Dragana, Milenković, Marina, Ivković, Branka, Larsen, Anders Rhod, Cirković, Ivana, "Inhibitory Effect of Newly-Synthesized Chalcones on Hemolytic Activity of Methicillin-Resistant Staphylococcus aureus" in Polish Journal of Microbiology, 64, no. 4 (2015):379-382,
https://doi.org/10.5604/17331331.1185237 . .
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