TY  - JOUR
AU  - Ibrić, Svetlana
AU  - Jovanović, Milica
AU  - Đurić, Zorica
AU  - Parojčić, Jelena
AU  - Solomun, Ljiljana
AU  - Lucić, Branka
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/922
AB  - This study had two aims. Firstly, we wanted to model the effects of the percentage of Eudragit RS PO and compression pressure as the most important process and formulation variables on the time course of drug release from extended-release matrix aspirin tablets. Secondly, we investigated the possibility of predicting drug stability and shelf-life using an artificial neural network (ANN). Ten types of matrix aspirin tablets were prepared as model formulations and were stored in stability chambers at 60 degrees C, 50 degrees C, 40 degrees C and 30 degrees C and controlled humidity. Samples were removed at predefined time points and analysed for acetylsalicylic acid (ASA) and salicylic acid (SA) content using stability-indicating HPLC. The decrease in aspirin content followed apparent zero-order kinetics. The amount of Eudragit RS PO and compression pressure were selected as causal factors. The apparent zero-order rate constants for each temperature were chosen as output variables for the ANN. A set of output parameters and causal factors were used as training data for the generalized regression neural network (GRNN). For two additional test formulations, Arrhenius plots were constructed from the experimentally observed and GRNN-predicted results. The slopes of experimentally observed and predicted Arrhenius plots were tested for significance using Student's t-test. For test formulations, the shelf life (t(95%)) was then calculated from experimentally observed values (t(95%) 82.90 weeks), as well as from GRNN-predicted values (t(95%) 81.88 weeks). These results demonstrate that GRNN networks can be used to predict ASA content and shelf life without stability testing for formulations in which the amount of polymer and tablet hardness are within the investigated range.
PB  - Pharmaceutical Press-Royal Pharmaceutical Soc Great Britian, London
T2  - Journal of Pharmacy and Pharmacology
T1  - Generalized regression neural networks in prediction of drug stability
VL  - 59
IS  - 5
SP  - 745
EP  - 750
DO  - 10.1211/jpp.59.5.0017
ER  - 

@article{
author = "Ibrić, Svetlana and Jovanović, Milica and Đurić, Zorica and Parojčić, Jelena and Solomun, Ljiljana and Lucić, Branka",
year = "2007",
abstract = "This study had two aims. Firstly, we wanted to model the effects of the percentage of Eudragit RS PO and compression pressure as the most important process and formulation variables on the time course of drug release from extended-release matrix aspirin tablets. Secondly, we investigated the possibility of predicting drug stability and shelf-life using an artificial neural network (ANN). Ten types of matrix aspirin tablets were prepared as model formulations and were stored in stability chambers at 60 degrees C, 50 degrees C, 40 degrees C and 30 degrees C and controlled humidity. Samples were removed at predefined time points and analysed for acetylsalicylic acid (ASA) and salicylic acid (SA) content using stability-indicating HPLC. The decrease in aspirin content followed apparent zero-order kinetics. The amount of Eudragit RS PO and compression pressure were selected as causal factors. The apparent zero-order rate constants for each temperature were chosen as output variables for the ANN. A set of output parameters and causal factors were used as training data for the generalized regression neural network (GRNN). For two additional test formulations, Arrhenius plots were constructed from the experimentally observed and GRNN-predicted results. The slopes of experimentally observed and predicted Arrhenius plots were tested for significance using Student's t-test. For test formulations, the shelf life (t(95%)) was then calculated from experimentally observed values (t(95%) 82.90 weeks), as well as from GRNN-predicted values (t(95%) 81.88 weeks). These results demonstrate that GRNN networks can be used to predict ASA content and shelf life without stability testing for formulations in which the amount of polymer and tablet hardness are within the investigated range.",
publisher = "Pharmaceutical Press-Royal Pharmaceutical Soc Great Britian, London",
journal = "Journal of Pharmacy and Pharmacology",
title = "Generalized regression neural networks in prediction of drug stability",
volume = "59",
number = "5",
pages = "745-750",
doi = "10.1211/jpp.59.5.0017"
}

Ibrić, S., Jovanović, M., Đurić, Z., Parojčić, J., Solomun, L.,& Lucić, B.. (2007). Generalized regression neural networks in prediction of drug stability. in Journal of Pharmacy and Pharmacology
Pharmaceutical Press-Royal Pharmaceutical Soc Great Britian, London., 59(5), 745-750.
https://doi.org/10.1211/jpp.59.5.0017

Ibrić S, Jovanović M, Đurić Z, Parojčić J, Solomun L, Lucić B. Generalized regression neural networks in prediction of drug stability. in Journal of Pharmacy and Pharmacology. 2007;59(5):745-750.
doi:10.1211/jpp.59.5.0017 .

Ibrić, Svetlana, Jovanović, Milica, Đurić, Zorica, Parojčić, Jelena, Solomun, Ljiljana, Lucić, Branka, "Generalized regression neural networks in prediction of drug stability" in Journal of Pharmacy and Pharmacology, 59, no. 5 (2007):745-750,
https://doi.org/10.1211/jpp.59.5.0017 . .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Ibrić, Svetlana
AU  - Đurić, Zorica
AU  - Jovanović, Milica
AU  - Corrigan, Owen I.
PY  - 2007
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/960
AB  - Quantitative correlations between in vivo and in vitro data (IVIVC) reduce the number of human in vivo studies, thus decreasing the overall time and expenses necessary for the development of optimal drug product formulation. Although linear regression analysis represents the simplest relationship, it is recognized that IVIVC should not be limited to linear relationship. With regards to the implementation of non-linear IVIVC models and the ability of artificial neural network (ANN) computing to cope with non-linear relationships, the usefulness of ANN analysis in the development of IVIVC merits further evaluation. The present paper is an attempt to develop an IVIVC for model sustained release paracetamol matrix tablet formulations employing various correlation approaches based on linear and non-linear modeling of in vitro and in vivo data. Currently accepted compendial methodology was compared with the alternative approaches, involving general mixed effects model and generalized regression neural network (GRNN) analysis, in order to evaluate their usefulness for predicting the in vivo behavior of drug products. Although based on analogous approaches, data generated by GRNN were closer to those observed in vivo, leading to the higher level of IVIVC than obtained by convolution. It can be assumed that GRNN analysis was able to generalize complex relations between the output and input parameters and could account for the differences in drug release kinetics observed under various conditions in vitro, thus offering potential as a reliable and robust estimate of drug products in vivo behavior.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation
VL  - 30
IS  - 3-4
SP  - 264
EP  - 272
DO  - 10.1016/j.ejps.2006.11.010
ER  - 

@article{
author = "Parojčić, Jelena and Ibrić, Svetlana and Đurić, Zorica and Jovanović, Milica and Corrigan, Owen I.",
year = "2007",
abstract = "Quantitative correlations between in vivo and in vitro data (IVIVC) reduce the number of human in vivo studies, thus decreasing the overall time and expenses necessary for the development of optimal drug product formulation. Although linear regression analysis represents the simplest relationship, it is recognized that IVIVC should not be limited to linear relationship. With regards to the implementation of non-linear IVIVC models and the ability of artificial neural network (ANN) computing to cope with non-linear relationships, the usefulness of ANN analysis in the development of IVIVC merits further evaluation. The present paper is an attempt to develop an IVIVC for model sustained release paracetamol matrix tablet formulations employing various correlation approaches based on linear and non-linear modeling of in vitro and in vivo data. Currently accepted compendial methodology was compared with the alternative approaches, involving general mixed effects model and generalized regression neural network (GRNN) analysis, in order to evaluate their usefulness for predicting the in vivo behavior of drug products. Although based on analogous approaches, data generated by GRNN were closer to those observed in vivo, leading to the higher level of IVIVC than obtained by convolution. It can be assumed that GRNN analysis was able to generalize complex relations between the output and input parameters and could account for the differences in drug release kinetics observed under various conditions in vitro, thus offering potential as a reliable and robust estimate of drug products in vivo behavior.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation",
volume = "30",
number = "3-4",
pages = "264-272",
doi = "10.1016/j.ejps.2006.11.010"
}

Parojčić, J., Ibrić, S., Đurić, Z., Jovanović, M.,& Corrigan, O. I.. (2007). An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 30(3-4), 264-272.
https://doi.org/10.1016/j.ejps.2006.11.010

Parojčić J, Ibrić S, Đurić Z, Jovanović M, Corrigan OI. An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation. in European Journal of Pharmaceutical Sciences. 2007;30(3-4):264-272.
doi:10.1016/j.ejps.2006.11.010 .

Parojčić, Jelena, Ibrić, Svetlana, Đurić, Zorica, Jovanović, Milica, Corrigan, Owen I., "An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation" in European Journal of Pharmaceutical Sciences, 30, no. 3-4 (2007):264-272,
https://doi.org/10.1016/j.ejps.2006.11.010 . .

TY  - CONF
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, Milica
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/740
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Application of optimization techniques in drug design and development
T1  - Primena optimizacionih tehnika u formulaciji farmaceutskih oblika
VL  - 56
IS  - 5
SP  - 1006
EP  - 1007
UR  - https://hdl.handle.net/21.15107/rcub_farfar_740
ER  - 

@conference{
author = "Ibrić, Svetlana and Parojčić, Jelena and Đurić, Zorica and Jovanović, Milica",
year = "2006",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Application of optimization techniques in drug design and development, Primena optimizacionih tehnika u formulaciji farmaceutskih oblika",
volume = "56",
number = "5",
pages = "1006-1007",
url = "https://hdl.handle.net/21.15107/rcub_farfar_740"
}

Ibrić, S., Parojčić, J., Đurić, Z.,& Jovanović, M.. (2006). Application of optimization techniques in drug design and development. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(5), 1006-1007.
https://hdl.handle.net/21.15107/rcub_farfar_740

Ibrić S, Parojčić J, Đurić Z, Jovanović M. Application of optimization techniques in drug design and development. in Arhiv za farmaciju. 2006;56(5):1006-1007.
https://hdl.handle.net/21.15107/rcub_farfar_740 .

Ibrić, Svetlana, Parojčić, Jelena, Đurić, Zorica, Jovanović, Milica, "Application of optimization techniques in drug design and development" in Arhiv za farmaciju, 56, no. 5 (2006):1006-1007,
https://hdl.handle.net/21.15107/rcub_farfar_740 .

TY  - JOUR
AU  - Ibrić, Svetlana
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, Milica
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/682
AB  - Within recent years the level of interest in both local and systemic vaginal drug delivery systems has increased considerably. The vagina offers advantages as a site for drug delivery, such as convenient access, prolonged retention of formulations, a great permeation area, high vaskularization, relatively low enzymatic activity, and the avoidance of first-pass metabolism. The rate and extent of drug absorption after intravaginal administration may vary depending on formulation factors, vaginal physiology, age of the patient. Peccaries, creams, gels, tablets, inserts and vaginal rings are commonly used dosage forms for vaginal drug delivery. The purpose of this communication is to provide the reader with a summary of advances made in the field of vaginal delivery with respect to preparations used in pregnancy and/or lactation.
AB  - Poslednjih godina je u porastu interes za vaginalnu primenu lekova, kako sa lokalnim, tako i sa sistemskim delovanjem. Vagina omogućava niz prednosti kao mesto za primenu terapijskih sistema, kao što su jednostavnost pristupa, duže zadržavanje formulacije na mestu primene, velika površina permeacije, dobra vaskularizacija, relativno niska enzimska aktivnost i izbegavanje efekta metabolizma prvog prolaza. Brzina i obim apsorpcije nakon intravaginalne primene lekova zavisi kako od fizioloških, tako i od farmaceutsko-tehnoloških faktora vezanih za vrstu i sastav lekovitog oblika. U radu su prikazani intravaginalni terapijski sistemi namenjeni za primenu u trudnoći, za indukciju porođaja ili kod dojilja, sa posebnim osvrtom na nove sisteme: vaginalne inserte, vaginalne prstenove, bioadhezivne preparate.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Intravaginal drug delivery systems: Application in pregnancy and lactation
T1  - Trudnoća i dojenje - mogućnost primene intravaginalnih terapijskih sistema
VL  - 56
IS  - 3
SP  - 240
EP  - 251
UR  - https://hdl.handle.net/21.15107/rcub_farfar_682
ER  - 

@article{
author = "Ibrić, Svetlana and Parojčić, Jelena and Đurić, Zorica and Jovanović, Milica",
year = "2006",
abstract = "Within recent years the level of interest in both local and systemic vaginal drug delivery systems has increased considerably. The vagina offers advantages as a site for drug delivery, such as convenient access, prolonged retention of formulations, a great permeation area, high vaskularization, relatively low enzymatic activity, and the avoidance of first-pass metabolism. The rate and extent of drug absorption after intravaginal administration may vary depending on formulation factors, vaginal physiology, age of the patient. Peccaries, creams, gels, tablets, inserts and vaginal rings are commonly used dosage forms for vaginal drug delivery. The purpose of this communication is to provide the reader with a summary of advances made in the field of vaginal delivery with respect to preparations used in pregnancy and/or lactation., Poslednjih godina je u porastu interes za vaginalnu primenu lekova, kako sa lokalnim, tako i sa sistemskim delovanjem. Vagina omogućava niz prednosti kao mesto za primenu terapijskih sistema, kao što su jednostavnost pristupa, duže zadržavanje formulacije na mestu primene, velika površina permeacije, dobra vaskularizacija, relativno niska enzimska aktivnost i izbegavanje efekta metabolizma prvog prolaza. Brzina i obim apsorpcije nakon intravaginalne primene lekova zavisi kako od fizioloških, tako i od farmaceutsko-tehnoloških faktora vezanih za vrstu i sastav lekovitog oblika. U radu su prikazani intravaginalni terapijski sistemi namenjeni za primenu u trudnoći, za indukciju porođaja ili kod dojilja, sa posebnim osvrtom na nove sisteme: vaginalne inserte, vaginalne prstenove, bioadhezivne preparate.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Intravaginal drug delivery systems: Application in pregnancy and lactation, Trudnoća i dojenje - mogućnost primene intravaginalnih terapijskih sistema",
volume = "56",
number = "3",
pages = "240-251",
url = "https://hdl.handle.net/21.15107/rcub_farfar_682"
}

Ibrić, S., Parojčić, J., Đurić, Z.,& Jovanović, M.. (2006). Intravaginal drug delivery systems: Application in pregnancy and lactation. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 56(3), 240-251.
https://hdl.handle.net/21.15107/rcub_farfar_682

Ibrić S, Parojčić J, Đurić Z, Jovanović M. Intravaginal drug delivery systems: Application in pregnancy and lactation. in Arhiv za farmaciju. 2006;56(3):240-251.
https://hdl.handle.net/21.15107/rcub_farfar_682 .

Ibrić, Svetlana, Parojčić, Jelena, Đurić, Zorica, Jovanović, Milica, "Intravaginal drug delivery systems: Application in pregnancy and lactation" in Arhiv za farmaciju, 56, no. 3 (2006):240-251,
https://hdl.handle.net/21.15107/rcub_farfar_682 .

TY  - JOUR
AU  - Đurić, Zorica
AU  - Jovanović, Milica
AU  - Parojčić, Jelena
AU  - Ibrić, Svetlana
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/491
AB  - In this report preparations of laxatives and antidiarrhoeals and the technological procedures used in production, have been reviewed.The importance of special technological procedure as freeze drying in the production and stabilisation has been explained. The most frequent dosage forms for these drugs are tablets.Good physical characteristics of tablets, insignificant variation of drug content, uniformity of dosage as required bioavailability are to bi provided by using adequate combination of excipients in the formulation and by proper selection of production method and order of technological operations.Additional requirements are to be achieved in the production of chewable tablets , frequently used as a dosage form for laxatives as calcium polycarbophil. Basic concept of tablet production validation is included in this report.
AB  - U radu su prikazani lekoviti preparati laksativa i antidijaroika i metode koje se koriste u proizvodnji. Objašnjen je značaj specijalnih tehnoloških postupaka kao što je liofilizacija u proizvodnji i stabilizaciji nekih proizvoda iz ove grupe.Najčešće primenjivani oblik ovih lekovitih supstanci su tablete. Za proizvodnju tableta koje će imati dobre fizičke karakteristike, zanemarljivo mala odstupanja u sadržaju leka, jednolikost doze kao i potrebnu bioraspoloživost, koristi se adekvatna kombinacija pomoćnih materija u formulaciji i pravilan izbor metode izrade. Dodatni zahtevi se postavljaju u slučaju proizvodnje tableta za žvakanje, kao što su tablete sa kalcijum polikarbofilom. U radu su dati i osnovni principi validacije procesa proizvodnje tableta.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Preparations of laxatives and antidiarrhoeals: Pharmaceutically - technological aspect
T1  - Lekoviti preparati lakasativa i antidijaroika - farmaceutsko tehnološki aspekt
VL  - 54
IS  - 3
SP  - 315
EP  - 332
UR  - https://hdl.handle.net/21.15107/rcub_farfar_491
ER  - 

@article{
author = "Đurić, Zorica and Jovanović, Milica and Parojčić, Jelena and Ibrić, Svetlana",
year = "2004",
abstract = "In this report preparations of laxatives and antidiarrhoeals and the technological procedures used in production, have been reviewed.The importance of special technological procedure as freeze drying in the production and stabilisation has been explained. The most frequent dosage forms for these drugs are tablets.Good physical characteristics of tablets, insignificant variation of drug content, uniformity of dosage as required bioavailability are to bi provided by using adequate combination of excipients in the formulation and by proper selection of production method and order of technological operations.Additional requirements are to be achieved in the production of chewable tablets , frequently used as a dosage form for laxatives as calcium polycarbophil. Basic concept of tablet production validation is included in this report., U radu su prikazani lekoviti preparati laksativa i antidijaroika i metode koje se koriste u proizvodnji. Objašnjen je značaj specijalnih tehnoloških postupaka kao što je liofilizacija u proizvodnji i stabilizaciji nekih proizvoda iz ove grupe.Najčešće primenjivani oblik ovih lekovitih supstanci su tablete. Za proizvodnju tableta koje će imati dobre fizičke karakteristike, zanemarljivo mala odstupanja u sadržaju leka, jednolikost doze kao i potrebnu bioraspoloživost, koristi se adekvatna kombinacija pomoćnih materija u formulaciji i pravilan izbor metode izrade. Dodatni zahtevi se postavljaju u slučaju proizvodnje tableta za žvakanje, kao što su tablete sa kalcijum polikarbofilom. U radu su dati i osnovni principi validacije procesa proizvodnje tableta.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Preparations of laxatives and antidiarrhoeals: Pharmaceutically - technological aspect, Lekoviti preparati lakasativa i antidijaroika - farmaceutsko tehnološki aspekt",
volume = "54",
number = "3",
pages = "315-332",
url = "https://hdl.handle.net/21.15107/rcub_farfar_491"
}

Đurić, Z., Jovanović, M., Parojčić, J.,& Ibrić, S.. (2004). Preparations of laxatives and antidiarrhoeals: Pharmaceutically - technological aspect. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 54(3), 315-332.
https://hdl.handle.net/21.15107/rcub_farfar_491

Đurić Z, Jovanović M, Parojčić J, Ibrić S. Preparations of laxatives and antidiarrhoeals: Pharmaceutically - technological aspect. in Arhiv za farmaciju. 2004;54(3):315-332.
https://hdl.handle.net/21.15107/rcub_farfar_491 .

Đurić, Zorica, Jovanović, Milica, Parojčić, Jelena, Ibrić, Svetlana, "Preparations of laxatives and antidiarrhoeals: Pharmaceutically - technological aspect" in Arhiv za farmaciju, 54, no. 3 (2004):315-332,
https://hdl.handle.net/21.15107/rcub_farfar_491 .

TY  - JOUR
AU  - Jovanović, Milica
AU  - Đurić, Zorica
AU  - Parojčić, Jelena
AU  - Ibrić, Svetlana
AU  - Milosavljević, Ana
PY  - 2003
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/452
AB  - Contemporary trends in dosage form development for cardiovascular therapeutics are orientated towards the rationalization and individualization of drug administration with the achievement of good compliance. Therefore, the controlled release dosage forms occupy an important place in the therapy of cardiovascular diseases. In this paper, the survey of commercially available modified release preparations in our country is given, as well as the most commonly employed technologies for development of controlled release dosage forms. Another aspect that is often used in order to attain the flexibility of dosing is divisibility of the scored tablets. The main reasons for tablet divisibility as well as the potential problems and disadvantages are discussed with regards to the literature data and experimental results obtained in a separate study.
AB  - Savremeni farmaceutsko-tehnološki pristup oblikovanju preparata u terapiji kardiovaskularnih oboljenja vezan je, pre svega, za individualizaciju i racionalizaciju terapije uz obezbeđenje dobre prihvatljivosti od strane pacijenta. U tom smislu, veliki značaj se pridaje razvoju formulacija i primeni peroralnih preparata sa kontrolisanim oslobađanjem aktivne komponente. U radu je dat prikaz najčešće zastupljenih tehnoloških rešenja u formulaciji savremenih, komercijalno dostupnih preparata sa kontrolisanim oslobađanjem, kao i pregled preparata ovog tipa registrovanih u našoj zemlji. Dodatni aspekt koji je često zastupljen u terapiji kardiovaskularnih oboljenja je i obezbeđenje fleksibilnosti doziranja koje se postiže deljenjem komercijalnio dostupnih tableta. Razlozi za deljenje tableta, kao i problemi i poteškoće koje pri tome mogu nastati prodiskutovani su u skladu sa navodima iz literature, kao i rezultatima sopstvenih istraživanja.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Dosage forms for cardiovascular therapeutics from the point of view of pharmaceutical technology
T1  - Lekoviti preparati u terapiji kardiovaskularnih oboljenja - savremeni farmaceutsko-tehnološki aspekt
VL  - 53
IS  - 5
SP  - 405
EP  - 418
UR  - https://hdl.handle.net/21.15107/rcub_farfar_452
ER  - 

@article{
author = "Jovanović, Milica and Đurić, Zorica and Parojčić, Jelena and Ibrić, Svetlana and Milosavljević, Ana",
year = "2003",
abstract = "Contemporary trends in dosage form development for cardiovascular therapeutics are orientated towards the rationalization and individualization of drug administration with the achievement of good compliance. Therefore, the controlled release dosage forms occupy an important place in the therapy of cardiovascular diseases. In this paper, the survey of commercially available modified release preparations in our country is given, as well as the most commonly employed technologies for development of controlled release dosage forms. Another aspect that is often used in order to attain the flexibility of dosing is divisibility of the scored tablets. The main reasons for tablet divisibility as well as the potential problems and disadvantages are discussed with regards to the literature data and experimental results obtained in a separate study., Savremeni farmaceutsko-tehnološki pristup oblikovanju preparata u terapiji kardiovaskularnih oboljenja vezan je, pre svega, za individualizaciju i racionalizaciju terapije uz obezbeđenje dobre prihvatljivosti od strane pacijenta. U tom smislu, veliki značaj se pridaje razvoju formulacija i primeni peroralnih preparata sa kontrolisanim oslobađanjem aktivne komponente. U radu je dat prikaz najčešće zastupljenih tehnoloških rešenja u formulaciji savremenih, komercijalno dostupnih preparata sa kontrolisanim oslobađanjem, kao i pregled preparata ovog tipa registrovanih u našoj zemlji. Dodatni aspekt koji je često zastupljen u terapiji kardiovaskularnih oboljenja je i obezbeđenje fleksibilnosti doziranja koje se postiže deljenjem komercijalnio dostupnih tableta. Razlozi za deljenje tableta, kao i problemi i poteškoće koje pri tome mogu nastati prodiskutovani su u skladu sa navodima iz literature, kao i rezultatima sopstvenih istraživanja.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Dosage forms for cardiovascular therapeutics from the point of view of pharmaceutical technology, Lekoviti preparati u terapiji kardiovaskularnih oboljenja - savremeni farmaceutsko-tehnološki aspekt",
volume = "53",
number = "5",
pages = "405-418",
url = "https://hdl.handle.net/21.15107/rcub_farfar_452"
}

Jovanović, M., Đurić, Z., Parojčić, J., Ibrić, S.,& Milosavljević, A.. (2003). Dosage forms for cardiovascular therapeutics from the point of view of pharmaceutical technology. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 53(5), 405-418.
https://hdl.handle.net/21.15107/rcub_farfar_452

Jovanović M, Đurić Z, Parojčić J, Ibrić S, Milosavljević A. Dosage forms for cardiovascular therapeutics from the point of view of pharmaceutical technology. in Arhiv za farmaciju. 2003;53(5):405-418.
https://hdl.handle.net/21.15107/rcub_farfar_452 .

Jovanović, Milica, Đurić, Zorica, Parojčić, Jelena, Ibrić, Svetlana, Milosavljević, Ana, "Dosage forms for cardiovascular therapeutics from the point of view of pharmaceutical technology" in Arhiv za farmaciju, 53, no. 5 (2003):405-418,
https://hdl.handle.net/21.15107/rcub_farfar_452 .

TY  - CONF
AU  - Ibrić, Svetlana
AU  - Jovanović, Milica
AU  - Đurić, Zorica
AU  - Parojčić, Jelena
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/408
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Application of model-dependent and modelindependent methods in comparison of in vitro dissolution profiles of aspirin from Eudragit RS PO matrix tablets
T1  - Primena model-zavisnih i model-nezavisnih metoda u proceni i poređenju profila brzine rastvaranja acetilsalicilne kiseline iz matriks tableta sa Eudragit-om RS PO
VL  - 52
IS  - 4
SP  - 562
EP  - 563
UR  - https://hdl.handle.net/21.15107/rcub_farfar_408
ER  - 

@conference{
author = "Ibrić, Svetlana and Jovanović, Milica and Đurić, Zorica and Parojčić, Jelena",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Application of model-dependent and modelindependent methods in comparison of in vitro dissolution profiles of aspirin from Eudragit RS PO matrix tablets, Primena model-zavisnih i model-nezavisnih metoda u proceni i poređenju profila brzine rastvaranja acetilsalicilne kiseline iz matriks tableta sa Eudragit-om RS PO",
volume = "52",
number = "4",
pages = "562-563",
url = "https://hdl.handle.net/21.15107/rcub_farfar_408"
}

Ibrić, S., Jovanović, M., Đurić, Z.,& Parojčić, J.. (2002). Application of model-dependent and modelindependent methods in comparison of in vitro dissolution profiles of aspirin from Eudragit RS PO matrix tablets. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 562-563.
https://hdl.handle.net/21.15107/rcub_farfar_408

Ibrić S, Jovanović M, Đurić Z, Parojčić J. Application of model-dependent and modelindependent methods in comparison of in vitro dissolution profiles of aspirin from Eudragit RS PO matrix tablets. in Arhiv za farmaciju. 2002;52(4):562-563.
https://hdl.handle.net/21.15107/rcub_farfar_408 .

Ibrić, Svetlana, Jovanović, Milica, Đurić, Zorica, Parojčić, Jelena, "Application of model-dependent and modelindependent methods in comparison of in vitro dissolution profiles of aspirin from Eudragit RS PO matrix tablets" in Arhiv za farmaciju, 52, no. 4 (2002):562-563,
https://hdl.handle.net/21.15107/rcub_farfar_408 .

TY  - CONF
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, Milica
AU  - Ibrić, Svetlana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/357
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Biopharmaceutical characterization of drug dosage forms: Basic considerations and importance
T1  - Biofarmaceutska karakterizacija lekovitih preparata: osnovni pojmovi i značaj
VL  - 52
IS  - 4
SP  - 530
EP  - 531
UR  - https://hdl.handle.net/21.15107/rcub_farfar_357
ER  - 

@conference{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, Milica and Ibrić, Svetlana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Biopharmaceutical characterization of drug dosage forms: Basic considerations and importance, Biofarmaceutska karakterizacija lekovitih preparata: osnovni pojmovi i značaj",
volume = "52",
number = "4",
pages = "530-531",
url = "https://hdl.handle.net/21.15107/rcub_farfar_357"
}

Parojčić, J., Đurić, Z., Jovanović, M.,& Ibrić, S.. (2002). Biopharmaceutical characterization of drug dosage forms: Basic considerations and importance. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 530-531.
https://hdl.handle.net/21.15107/rcub_farfar_357

Parojčić J, Đurić Z, Jovanović M, Ibrić S. Biopharmaceutical characterization of drug dosage forms: Basic considerations and importance. in Arhiv za farmaciju. 2002;52(4):530-531.
https://hdl.handle.net/21.15107/rcub_farfar_357 .

Parojčić, Jelena, Đurić, Zorica, Jovanović, Milica, Ibrić, Svetlana, "Biopharmaceutical characterization of drug dosage forms: Basic considerations and importance" in Arhiv za farmaciju, 52, no. 4 (2002):530-531,
https://hdl.handle.net/21.15107/rcub_farfar_357 .

TY  - CONF
AU  - Ibrić, Svetlana
AU  - Jovanović, Milica
AU  - Đurić, Zorica
AU  - Parojčić, Jelena
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/401
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Application of artificial neural network (ANN) in development of solid dosage forms
T1  - Primena veštačkih neuronskih mreža u razvoju čvrstih doziranih oblika
VL  - 52
IS  - 4
SP  - 536
EP  - 537
UR  - https://hdl.handle.net/21.15107/rcub_farfar_401
ER  - 

@conference{
author = "Ibrić, Svetlana and Jovanović, Milica and Đurić, Zorica and Parojčić, Jelena",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Application of artificial neural network (ANN) in development of solid dosage forms, Primena veštačkih neuronskih mreža u razvoju čvrstih doziranih oblika",
volume = "52",
number = "4",
pages = "536-537",
url = "https://hdl.handle.net/21.15107/rcub_farfar_401"
}

Ibrić, S., Jovanović, M., Đurić, Z.,& Parojčić, J.. (2002). Application of artificial neural network (ANN) in development of solid dosage forms. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 536-537.
https://hdl.handle.net/21.15107/rcub_farfar_401

Ibrić S, Jovanović M, Đurić Z, Parojčić J. Application of artificial neural network (ANN) in development of solid dosage forms. in Arhiv za farmaciju. 2002;52(4):536-537.
https://hdl.handle.net/21.15107/rcub_farfar_401 .

Ibrić, Svetlana, Jovanović, Milica, Đurić, Zorica, Parojčić, Jelena, "Application of artificial neural network (ANN) in development of solid dosage forms" in Arhiv za farmaciju, 52, no. 4 (2002):536-537,
https://hdl.handle.net/21.15107/rcub_farfar_401 .

TY  - CONF
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, Milica
AU  - Ibrić, Svetlana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/367
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - An investigation into the effect of polymer concentration and tablet size on paracetamol release kinetics from Carbopol 971P matrix tablets
T1  - Uticaj koncentracije polimera i veličine tableta na kinetiku oslobađanja paracetamola iz matriks tableta izrađenih sa Carbopolom 971P
VL  - 52
IS  - 4
SP  - 566
EP  - 567
UR  - https://hdl.handle.net/21.15107/rcub_farfar_367
ER  - 

@conference{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, Milica and Ibrić, Svetlana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "An investigation into the effect of polymer concentration and tablet size on paracetamol release kinetics from Carbopol 971P matrix tablets, Uticaj koncentracije polimera i veličine tableta na kinetiku oslobađanja paracetamola iz matriks tableta izrađenih sa Carbopolom 971P",
volume = "52",
number = "4",
pages = "566-567",
url = "https://hdl.handle.net/21.15107/rcub_farfar_367"
}

Parojčić, J., Đurić, Z., Jovanović, M.,& Ibrić, S.. (2002). An investigation into the effect of polymer concentration and tablet size on paracetamol release kinetics from Carbopol 971P matrix tablets. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 566-567.
https://hdl.handle.net/21.15107/rcub_farfar_367

Parojčić J, Đurić Z, Jovanović M, Ibrić S. An investigation into the effect of polymer concentration and tablet size on paracetamol release kinetics from Carbopol 971P matrix tablets. in Arhiv za farmaciju. 2002;52(4):566-567.
https://hdl.handle.net/21.15107/rcub_farfar_367 .

Parojčić, Jelena, Đurić, Zorica, Jovanović, Milica, Ibrić, Svetlana, "An investigation into the effect of polymer concentration and tablet size on paracetamol release kinetics from Carbopol 971P matrix tablets" in Arhiv za farmaciju, 52, no. 4 (2002):566-567,
https://hdl.handle.net/21.15107/rcub_farfar_367 .