TY  - JOUR
AU  - Pavlov-Dolijanović, Slavica
AU  - Vujasinović-Stupar, Nada
AU  - Zugić, Vladimir
AU  - Ostojić, Predrag
AU  - Zeković, Ana
AU  - Živanović-Radnić, Tatjana
AU  - Jeremić, Ivan
AU  - Tadić, Ivana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3066
AB  - The study aims to analyze the effects of induction treatment with cyclophosphamide (CYC) pulse therapy followed by maintenance treatment with other mild immunosuppressive agents on lung function in scleroderma (SSc) patients. Thirty patients with SSc (mean age 52years, mean disease duration  lt 2years) with forced vital capacity (FVC) 80% and/or diffusing capacity of carbon monoxide (DLco) 70% were included. Monthly CYC pulses were given for 6months (induction treatment), followed by 3-monthly maintenance pulses for the next 18months, and during the next 5years patients received other mild immunosupressive therapy brought by the competent rheumatologist. The efficacy was evaluated by comparing FVC% and DLco% after 6, 24, and 84months from the baseline. All patients completed induction and maintenance treatment with CYC. Three patients were lost to follow-up. The rest of 27 patients, during the next 5years, received other immunosupressive agents (14 azathioprine, 9 methotrexate, and 4 mycophenolate mofetil). Three patients died in the 4years of follow-up. By 6, 24, and 84months, the mean FVC and DLco changes were +0.47 and +2.10, +3.30 and -2.49, and +1.53 and -3.76%, respectively. These changes were not significantly different from the baseline values. CYC does not appear to result in clinically significant improvement of pulmonary function but fulfilled criteria of stable disease. Maintenance treatment with other mild immunosupressive agents preserves the benefits achieved during CYC treatment.
PB  - Springer
T2  - Clinical Rheumatology
T1  - Long-term effects of immunosuppressive therapy on lung function in scleroderma patients
VL  - 37
IS  - 11
SP  - 3043
EP  - 3050
DO  - 10.1007/s10067-018-4266-0
ER  - 

@article{
author = "Pavlov-Dolijanović, Slavica and Vujasinović-Stupar, Nada and Zugić, Vladimir and Ostojić, Predrag and Zeković, Ana and Živanović-Radnić, Tatjana and Jeremić, Ivan and Tadić, Ivana",
year = "2018",
abstract = "The study aims to analyze the effects of induction treatment with cyclophosphamide (CYC) pulse therapy followed by maintenance treatment with other mild immunosuppressive agents on lung function in scleroderma (SSc) patients. Thirty patients with SSc (mean age 52years, mean disease duration  lt 2years) with forced vital capacity (FVC) 80% and/or diffusing capacity of carbon monoxide (DLco) 70% were included. Monthly CYC pulses were given for 6months (induction treatment), followed by 3-monthly maintenance pulses for the next 18months, and during the next 5years patients received other mild immunosupressive therapy brought by the competent rheumatologist. The efficacy was evaluated by comparing FVC% and DLco% after 6, 24, and 84months from the baseline. All patients completed induction and maintenance treatment with CYC. Three patients were lost to follow-up. The rest of 27 patients, during the next 5years, received other immunosupressive agents (14 azathioprine, 9 methotrexate, and 4 mycophenolate mofetil). Three patients died in the 4years of follow-up. By 6, 24, and 84months, the mean FVC and DLco changes were +0.47 and +2.10, +3.30 and -2.49, and +1.53 and -3.76%, respectively. These changes were not significantly different from the baseline values. CYC does not appear to result in clinically significant improvement of pulmonary function but fulfilled criteria of stable disease. Maintenance treatment with other mild immunosupressive agents preserves the benefits achieved during CYC treatment.",
publisher = "Springer",
journal = "Clinical Rheumatology",
title = "Long-term effects of immunosuppressive therapy on lung function in scleroderma patients",
volume = "37",
number = "11",
pages = "3043-3050",
doi = "10.1007/s10067-018-4266-0"
}

Pavlov-Dolijanović, S., Vujasinović-Stupar, N., Zugić, V., Ostojić, P., Zeković, A., Živanović-Radnić, T., Jeremić, I.,& Tadić, I.. (2018). Long-term effects of immunosuppressive therapy on lung function in scleroderma patients. in Clinical Rheumatology
Springer., 37(11), 3043-3050.
https://doi.org/10.1007/s10067-018-4266-0

Pavlov-Dolijanović S, Vujasinović-Stupar N, Zugić V, Ostojić P, Zeković A, Živanović-Radnić T, Jeremić I, Tadić I. Long-term effects of immunosuppressive therapy on lung function in scleroderma patients. in Clinical Rheumatology. 2018;37(11):3043-3050.
doi:10.1007/s10067-018-4266-0 .

Pavlov-Dolijanović, Slavica, Vujasinović-Stupar, Nada, Zugić, Vladimir, Ostojić, Predrag, Zeković, Ana, Živanović-Radnić, Tatjana, Jeremić, Ivan, Tadić, Ivana, "Long-term effects of immunosuppressive therapy on lung function in scleroderma patients" in Clinical Rheumatology, 37, no. 11 (2018):3043-3050,
https://doi.org/10.1007/s10067-018-4266-0 . .