Varagić, V.M.

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  • Varagić, V.M. (13)
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Author's Bibliography

Disposition of Lamotrigine in children with epilepsy receiving politherapy

Brzaković, Branka; Pokrajac, Milena; Martinović, Žarko J.; Veličković, Ružica; Miljković, Branislava; Varagić, V.M.

(Savez farmaceutskih udruženja Srbije, Beograd, 2002)

TY  - CONF
AU  - Brzaković, Branka
AU  - Pokrajac, Milena
AU  - Martinović, Žarko J.
AU  - Veličković, Ružica
AU  - Miljković, Branislava
AU  - Varagić, V.M.
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/363
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Disposition of Lamotrigine in children with epilepsy receiving politherapy
T1  - Dispozicija Lamotrigina u kombinovano terapiji dece sa epilepsijom
VL  - 52
IS  - 4
SP  - 668
EP  - 669
UR  - https://hdl.handle.net/21.15107/rcub_farfar_363
ER  - 
@conference{
author = "Brzaković, Branka and Pokrajac, Milena and Martinović, Žarko J. and Veličković, Ružica and Miljković, Branislava and Varagić, V.M.",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Disposition of Lamotrigine in children with epilepsy receiving politherapy, Dispozicija Lamotrigina u kombinovano terapiji dece sa epilepsijom",
volume = "52",
number = "4",
pages = "668-669",
url = "https://hdl.handle.net/21.15107/rcub_farfar_363"
}
Brzaković, B., Pokrajac, M., Martinović, Ž. J., Veličković, R., Miljković, B.,& Varagić, V.M.. (2002). Disposition of Lamotrigine in children with epilepsy receiving politherapy. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 668-669.
https://hdl.handle.net/21.15107/rcub_farfar_363
Brzaković B, Pokrajac M, Martinović ŽJ, Veličković R, Miljković B, Varagić V. Disposition of Lamotrigine in children with epilepsy receiving politherapy. in Arhiv za farmaciju. 2002;52(4):668-669.
https://hdl.handle.net/21.15107/rcub_farfar_363 .
Brzaković, Branka, Pokrajac, Milena, Martinović, Žarko J., Veličković, Ružica, Miljković, Branislava, Varagić, V.M., "Disposition of Lamotrigine in children with epilepsy receiving politherapy" in Arhiv za farmaciju, 52, no. 4 (2002):668-669,
https://hdl.handle.net/21.15107/rcub_farfar_363 .

The influence of lithium on fluvoxamine therapeutic efficacy and pharmacokinetics in depressed patients on combined fluvoxamine-lithium therapy

Miljković, Branislava; Pokrajac, Milena; Timotijević, Ivana; Varagić, V.M.

(Rapid Science Publishers, London, 1997)

TY  - JOUR
AU  - Miljković, Branislava
AU  - Pokrajac, Milena
AU  - Timotijević, Ivana
AU  - Varagić, V.M.
PY  - 1997
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/155
AB  - The influence of lithium on fluvoxamine therapeutic efficacy, plasma concentrations and pharmacokinetics was studied in 12 depressed inpatients. Six patients were on fluvoxamine monotherapy and six were on combined fluvoxamine-lithium therapy. The treatment response was determined using 17-item Hamilton Rating Scale for Depression. Blood samples were collected during 48 h after a single dose administration of 100 mg fluvoxamine, and five times at steady state after repeated doses of 100 mg fluvoxamine per day. The evaluation of 17-item Hamilton Rating Scale for Depression Scores showed a significant clinical improvement 2 and 4 weeks after the beginning of the therapy in both groups (p  lt  0.01). However, 2 weeks after the administration of the drug(s) had started, significant differences (p  lt  0.05) in efficacy between the two treatments in favour of the fluvoxamine-lithium combination were found. Plasma concentrations of fluvoxamine were measured by high-performance liquid chromatography. The comparison of the measured concentrations of fluvoxamine showed a similar course of the plasma concentration-time curves in both groups of patients. Pharmacokinetic parameters of fluvoxamine did not show any significant difference on the comparison between the groups. According to the results from this study, it is evident that lithium does not affect plasma concentrations and pharmacokinetics of fluvoxamine in depressed patients on concomitant treatment with these two drugs. However, the effect achieved with the combination was better.
PB  - Rapid Science Publishers, London
T2  - International Clinical Psychopharmacology
T1  - The influence of lithium on fluvoxamine therapeutic efficacy and pharmacokinetics in depressed patients on combined fluvoxamine-lithium therapy
VL  - 12
IS  - 4
SP  - 207
EP  - 212
DO  - 10.1097/00004850-199707000-00004
ER  - 
@article{
author = "Miljković, Branislava and Pokrajac, Milena and Timotijević, Ivana and Varagić, V.M.",
year = "1997",
abstract = "The influence of lithium on fluvoxamine therapeutic efficacy, plasma concentrations and pharmacokinetics was studied in 12 depressed inpatients. Six patients were on fluvoxamine monotherapy and six were on combined fluvoxamine-lithium therapy. The treatment response was determined using 17-item Hamilton Rating Scale for Depression. Blood samples were collected during 48 h after a single dose administration of 100 mg fluvoxamine, and five times at steady state after repeated doses of 100 mg fluvoxamine per day. The evaluation of 17-item Hamilton Rating Scale for Depression Scores showed a significant clinical improvement 2 and 4 weeks after the beginning of the therapy in both groups (p  lt  0.01). However, 2 weeks after the administration of the drug(s) had started, significant differences (p  lt  0.05) in efficacy between the two treatments in favour of the fluvoxamine-lithium combination were found. Plasma concentrations of fluvoxamine were measured by high-performance liquid chromatography. The comparison of the measured concentrations of fluvoxamine showed a similar course of the plasma concentration-time curves in both groups of patients. Pharmacokinetic parameters of fluvoxamine did not show any significant difference on the comparison between the groups. According to the results from this study, it is evident that lithium does not affect plasma concentrations and pharmacokinetics of fluvoxamine in depressed patients on concomitant treatment with these two drugs. However, the effect achieved with the combination was better.",
publisher = "Rapid Science Publishers, London",
journal = "International Clinical Psychopharmacology",
title = "The influence of lithium on fluvoxamine therapeutic efficacy and pharmacokinetics in depressed patients on combined fluvoxamine-lithium therapy",
volume = "12",
number = "4",
pages = "207-212",
doi = "10.1097/00004850-199707000-00004"
}
Miljković, B., Pokrajac, M., Timotijević, I.,& Varagić, V.M.. (1997). The influence of lithium on fluvoxamine therapeutic efficacy and pharmacokinetics in depressed patients on combined fluvoxamine-lithium therapy. in International Clinical Psychopharmacology
Rapid Science Publishers, London., 12(4), 207-212.
https://doi.org/10.1097/00004850-199707000-00004
Miljković B, Pokrajac M, Timotijević I, Varagić V. The influence of lithium on fluvoxamine therapeutic efficacy and pharmacokinetics in depressed patients on combined fluvoxamine-lithium therapy. in International Clinical Psychopharmacology. 1997;12(4):207-212.
doi:10.1097/00004850-199707000-00004 .
Miljković, Branislava, Pokrajac, Milena, Timotijević, Ivana, Varagić, V.M., "The influence of lithium on fluvoxamine therapeutic efficacy and pharmacokinetics in depressed patients on combined fluvoxamine-lithium therapy" in International Clinical Psychopharmacology, 12, no. 4 (1997):207-212,
https://doi.org/10.1097/00004850-199707000-00004 . .
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Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients

Miljković, Branislava; Pokrajac, Milena; Timotijević, Ivana; Varagić, V.M.

(Medecine Et Hygiene, Geneva 4, 1996)

TY  - JOUR
AU  - Miljković, Branislava
AU  - Pokrajac, Milena
AU  - Timotijević, Ivana
AU  - Varagić, V.M.
PY  - 1996
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/142
AB  - Although many attempts have been made, to date no convincing evidence exists of a relationship between plasma concentrations of amitriptyline (AT), its active metabolite nortriptyline (NT) and clinical response. Fifteen patients with primary depression (according to DSM-IV) were divided in two groups according to given doses: (I) 6 patients received 3 x 50 mg of AT daily; and (II) 9 patients received 3 x 25 mg of AT daily, for 6 weeks. The clinical status was determined with Hamilton Depression Rating Scale. Both investigated doses were therapeutically effective. AT and NT plasma concentrations were assayed by high performance liquid chromatography. Following administration of 3 x 50 mg of AT daily, the correlation of concentrations of AT, NT, total AT+NT and clinical response were r(AT) = -0.702 (P  lt  0.1), r(NT) = -0.761 (P  lt  0.1), r(AT+NT) = -0.741 (P  lt  0.1). The linear and very high correlation were also present with concentrations of AT, NT, total AT+NT and clinical response in depressive patients on 3 x 25 mg AT daily: r(AT) = -0.785 (P  lt  0.02), r(NT) = -0.811 (P  lt  0.01), r(AT+NT) = -0.848 (P  lt  0.01). Our results support a high correlation between AT/NT plasma concentrations and clinical response indicating that therapeutic monitoring of AT and its metabolite, NT, can provide eventual clinical response.
PB  - Medecine Et Hygiene, Geneva 4
T2  - European Journal of Drug Metabolism and Pharmacokinetics
T1  - Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients
VL  - 21
IS  - 3
SP  - 251
EP  - 255
DO  - 10.1007/BF03189722
ER  - 
@article{
author = "Miljković, Branislava and Pokrajac, Milena and Timotijević, Ivana and Varagić, V.M.",
year = "1996",
abstract = "Although many attempts have been made, to date no convincing evidence exists of a relationship between plasma concentrations of amitriptyline (AT), its active metabolite nortriptyline (NT) and clinical response. Fifteen patients with primary depression (according to DSM-IV) were divided in two groups according to given doses: (I) 6 patients received 3 x 50 mg of AT daily; and (II) 9 patients received 3 x 25 mg of AT daily, for 6 weeks. The clinical status was determined with Hamilton Depression Rating Scale. Both investigated doses were therapeutically effective. AT and NT plasma concentrations were assayed by high performance liquid chromatography. Following administration of 3 x 50 mg of AT daily, the correlation of concentrations of AT, NT, total AT+NT and clinical response were r(AT) = -0.702 (P  lt  0.1), r(NT) = -0.761 (P  lt  0.1), r(AT+NT) = -0.741 (P  lt  0.1). The linear and very high correlation were also present with concentrations of AT, NT, total AT+NT and clinical response in depressive patients on 3 x 25 mg AT daily: r(AT) = -0.785 (P  lt  0.02), r(NT) = -0.811 (P  lt  0.01), r(AT+NT) = -0.848 (P  lt  0.01). Our results support a high correlation between AT/NT plasma concentrations and clinical response indicating that therapeutic monitoring of AT and its metabolite, NT, can provide eventual clinical response.",
publisher = "Medecine Et Hygiene, Geneva 4",
journal = "European Journal of Drug Metabolism and Pharmacokinetics",
title = "Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients",
volume = "21",
number = "3",
pages = "251-255",
doi = "10.1007/BF03189722"
}
Miljković, B., Pokrajac, M., Timotijević, I.,& Varagić, V.M.. (1996). Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients. in European Journal of Drug Metabolism and Pharmacokinetics
Medecine Et Hygiene, Geneva 4., 21(3), 251-255.
https://doi.org/10.1007/BF03189722
Miljković B, Pokrajac M, Timotijević I, Varagić V. Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients. in European Journal of Drug Metabolism and Pharmacokinetics. 1996;21(3):251-255.
doi:10.1007/BF03189722 .
Miljković, Branislava, Pokrajac, Milena, Timotijević, Ivana, Varagić, V.M., "Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients" in European Journal of Drug Metabolism and Pharmacokinetics, 21, no. 3 (1996):251-255,
https://doi.org/10.1007/BF03189722 . .
6
10
9

Pharmacokinetic interaction between valproic acid and phenobarbital

Pokrajac, Milena; Miljković, Branislava; Varagić, V.M.; Lević, Z

(1993)

TY  - JOUR
AU  - Pokrajac, Milena
AU  - Miljković, Branislava
AU  - Varagić, V.M.
AU  - Lević, Z
PY  - 1993
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/106
T2  - Biopharmaceutics & Drug Disposition
T1  - Pharmacokinetic interaction between valproic acid and phenobarbital
VL  - 14
IS  - 1
SP  - 81
EP  - 86
DO  - 10.1002/bdd.2510140108
ER  - 
@article{
author = "Pokrajac, Milena and Miljković, Branislava and Varagić, V.M. and Lević, Z",
year = "1993",
journal = "Biopharmaceutics & Drug Disposition",
title = "Pharmacokinetic interaction between valproic acid and phenobarbital",
volume = "14",
number = "1",
pages = "81-86",
doi = "10.1002/bdd.2510140108"
}
Pokrajac, M., Miljković, B., Varagić, V.M.,& Lević, Z.. (1993). Pharmacokinetic interaction between valproic acid and phenobarbital. in Biopharmaceutics & Drug Disposition, 14(1), 81-86.
https://doi.org/10.1002/bdd.2510140108
Pokrajac M, Miljković B, Varagić V, Lević Z. Pharmacokinetic interaction between valproic acid and phenobarbital. in Biopharmaceutics & Drug Disposition. 1993;14(1):81-86.
doi:10.1002/bdd.2510140108 .
Pokrajac, Milena, Miljković, Branislava, Varagić, V.M., Lević, Z, "Pharmacokinetic interaction between valproic acid and phenobarbital" in Biopharmaceutics & Drug Disposition, 14, no. 1 (1993):81-86,
https://doi.org/10.1002/bdd.2510140108 . .
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An improved gas chromatographic determination of valproic acid and valpromide in plasma

Pokrajac, Milena; Miljković, Branislava; Spiridonović, D; Varagić, V.M.

(1992)

TY  - JOUR
AU  - Pokrajac, Milena
AU  - Miljković, Branislava
AU  - Spiridonović, D
AU  - Varagić, V.M.
PY  - 1992
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/95
T2  - Pharmaceutica Acta Helvetiae
T1  - An improved gas chromatographic determination of valproic acid and valpromide in plasma
VL  - 67
IS  - 8
SP  - 237
EP  - 240
UR  - https://hdl.handle.net/21.15107/rcub_farfar_95
ER  - 
@article{
author = "Pokrajac, Milena and Miljković, Branislava and Spiridonović, D and Varagić, V.M.",
year = "1992",
journal = "Pharmaceutica Acta Helvetiae",
title = "An improved gas chromatographic determination of valproic acid and valpromide in plasma",
volume = "67",
number = "8",
pages = "237-240",
url = "https://hdl.handle.net/21.15107/rcub_farfar_95"
}
Pokrajac, M., Miljković, B., Spiridonović, D.,& Varagić, V.M.. (1992). An improved gas chromatographic determination of valproic acid and valpromide in plasma. in Pharmaceutica Acta Helvetiae, 67(8), 237-240.
https://hdl.handle.net/21.15107/rcub_farfar_95
Pokrajac M, Miljković B, Spiridonović D, Varagić V. An improved gas chromatographic determination of valproic acid and valpromide in plasma. in Pharmaceutica Acta Helvetiae. 1992;67(8):237-240.
https://hdl.handle.net/21.15107/rcub_farfar_95 .
Pokrajac, Milena, Miljković, Branislava, Spiridonović, D, Varagić, V.M., "An improved gas chromatographic determination of valproic acid and valpromide in plasma" in Pharmaceutica Acta Helvetiae, 67, no. 8 (1992):237-240,
https://hdl.handle.net/21.15107/rcub_farfar_95 .
6

Single dosa and steady state pharmacokinetics of valproic acid in adult epileptic patients

Miljković, Branislava; Pokrajac, Milena; Varagić, V.M.; Lević, Z

(1991)

TY  - JOUR
AU  - Miljković, Branislava
AU  - Pokrajac, Milena
AU  - Varagić, V.M.
AU  - Lević, Z
PY  - 1991
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/84
T2  - International Journal of Clinical Pharmacology Research
T1  - Single dosa and steady state pharmacokinetics of valproic acid in adult epileptic patients
VL  - 11
IS  - 3
SP  - 137
EP  - 141
UR  - https://hdl.handle.net/21.15107/rcub_farfar_84
ER  - 
@article{
author = "Miljković, Branislava and Pokrajac, Milena and Varagić, V.M. and Lević, Z",
year = "1991",
journal = "International Journal of Clinical Pharmacology Research",
title = "Single dosa and steady state pharmacokinetics of valproic acid in adult epileptic patients",
volume = "11",
number = "3",
pages = "137-141",
url = "https://hdl.handle.net/21.15107/rcub_farfar_84"
}
Miljković, B., Pokrajac, M., Varagić, V.M.,& Lević, Z.. (1991). Single dosa and steady state pharmacokinetics of valproic acid in adult epileptic patients. in International Journal of Clinical Pharmacology Research, 11(3), 137-141.
https://hdl.handle.net/21.15107/rcub_farfar_84
Miljković B, Pokrajac M, Varagić V, Lević Z. Single dosa and steady state pharmacokinetics of valproic acid in adult epileptic patients. in International Journal of Clinical Pharmacology Research. 1991;11(3):137-141.
https://hdl.handle.net/21.15107/rcub_farfar_84 .
Miljković, Branislava, Pokrajac, Milena, Varagić, V.M., Lević, Z, "Single dosa and steady state pharmacokinetics of valproic acid in adult epileptic patients" in International Journal of Clinical Pharmacology Research, 11, no. 3 (1991):137-141,
https://hdl.handle.net/21.15107/rcub_farfar_84 .
8

When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline.

Pokrajac, Milena; Agbaba, Danica; Miljković, Branislava; Varagić, V.M.

(1991)

TY  - JOUR
AU  - Pokrajac, Milena
AU  - Agbaba, Danica
AU  - Miljković, Branislava
AU  - Varagić, V.M.
PY  - 1991
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/90
AB  - Special interest in alternative approach to clinical pharmacokinetic research nowadays, especially in pediatric practice, is concerned on biological fluids obtainable by non- invasive methodology. Saliva and urine are the most interesting fluids in this approach. The possibility of using saliva and urine was investigated and evaluated in theophylline (Th) therapy, both in asthmatic children and adults. The investigation on drug presence in saliva (asthmatic children and adults) and in urine (asthmatic children) during Th therapy, confirmed good correlation between saliva and plasma, and between urine and plasma, and provided reliable basis for the conclusion that both saliva and urine can be used in pharmacokinetic research of The elimination in asthmatic children. Only saliva was investigated in adult patients and it was found that it can be used as alternative biological fluid in pharmacokinetic research, but with less reliability than in children.
T2  - European Journal of Drug Metabolism and Pharmacokinetics
T1  - When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline.
SP  - 513
EP  - 518
UR  - https://hdl.handle.net/21.15107/rcub_farfar_90
ER  - 
@article{
author = "Pokrajac, Milena and Agbaba, Danica and Miljković, Branislava and Varagić, V.M.",
year = "1991",
abstract = "Special interest in alternative approach to clinical pharmacokinetic research nowadays, especially in pediatric practice, is concerned on biological fluids obtainable by non- invasive methodology. Saliva and urine are the most interesting fluids in this approach. The possibility of using saliva and urine was investigated and evaluated in theophylline (Th) therapy, both in asthmatic children and adults. The investigation on drug presence in saliva (asthmatic children and adults) and in urine (asthmatic children) during Th therapy, confirmed good correlation between saliva and plasma, and between urine and plasma, and provided reliable basis for the conclusion that both saliva and urine can be used in pharmacokinetic research of The elimination in asthmatic children. Only saliva was investigated in adult patients and it was found that it can be used as alternative biological fluid in pharmacokinetic research, but with less reliability than in children.",
journal = "European Journal of Drug Metabolism and Pharmacokinetics",
title = "When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline.",
pages = "513-518",
url = "https://hdl.handle.net/21.15107/rcub_farfar_90"
}
Pokrajac, M., Agbaba, D., Miljković, B.,& Varagić, V.M.. (1991). When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline.. in European Journal of Drug Metabolism and Pharmacokinetics, 513-518.
https://hdl.handle.net/21.15107/rcub_farfar_90
Pokrajac M, Agbaba D, Miljković B, Varagić V. When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline.. in European Journal of Drug Metabolism and Pharmacokinetics. 1991;:513-518.
https://hdl.handle.net/21.15107/rcub_farfar_90 .
Pokrajac, Milena, Agbaba, Danica, Miljković, Branislava, Varagić, V.M., "When is the use of alternative biological fluid in pharmacokinetics possible; an example of theophylline." in European Journal of Drug Metabolism and Pharmacokinetics (1991):513-518,
https://hdl.handle.net/21.15107/rcub_farfar_90 .

Dependence of the Renal Excretion of Theophylline on its Plasma Concentrations and Urine Flow Rate in Asthmatic Children

Agbaba, Danica; Pokrajac, Milena; Varagić, V.M.; Pešić, V.

(1990)

TY  - JOUR
AU  - Agbaba, Danica
AU  - Pokrajac, Milena
AU  - Varagić, V.M.
AU  - Pešić, V.
PY  - 1990
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/65
AB  - Abstract— The dependence of the renal excretion of theophylline on its plasma concentration and urine flow rate has been investigated in asthmatic children of either sex. One group (age 12.25 ± 0.80, mean ± s.d. n = 8) was given aminophylline intravenously (i.v.), while another (age 10.00 ± 3.64 n = 14) was given a sustained release preparation of theophylline orally (single dose and repeated doses). Unchanged drug (11.6% ± 1.75) was excreted in the urine corresponding to a renal clearance of 10.6 ± 1.6 mL h−1 kg−1. Time dependence of the renal clearance of theophylline was found only after i.v. administration. Dependence of the renal clearance on urine flow rate was found both after i.v. administration and at steady state, but not after a single oral dose of theophylline. After oral administration, renal clearance of theophylline was higher at steady state than after a single dose (0.58 ± 0.06 L h−1 kg−1 vs 0.23 ± 0.03 L h−1 kg−1), while urine flow rate was lower (1.1 ± 0.5 mL min−1 vs 1.8 ± 0.9 mL min−1). High correlation of theophylline plasma concentration and theophylline excretion rate was obtained in 10 of 14 patients after administration of a single oral dose of the preparation (r = 0.8567 to 0.9830). There was no dose dependence of the renal clearance of the drug either after a single dose, or at steady state. 1990 Royal Pharmaceutical Society of Great Britain
T2  - Journal of Pharmacy and Pharmacology
T1  - Dependence of the Renal Excretion of Theophylline on its Plasma Concentrations and Urine Flow Rate in Asthmatic Children
VL  - 42
IS  - 12
SP  - 827
EP  - 830
DO  - 10.1111/j.2042-7158.1990.tb07034.x
ER  - 
@article{
author = "Agbaba, Danica and Pokrajac, Milena and Varagić, V.M. and Pešić, V.",
year = "1990",
abstract = "Abstract— The dependence of the renal excretion of theophylline on its plasma concentration and urine flow rate has been investigated in asthmatic children of either sex. One group (age 12.25 ± 0.80, mean ± s.d. n = 8) was given aminophylline intravenously (i.v.), while another (age 10.00 ± 3.64 n = 14) was given a sustained release preparation of theophylline orally (single dose and repeated doses). Unchanged drug (11.6% ± 1.75) was excreted in the urine corresponding to a renal clearance of 10.6 ± 1.6 mL h−1 kg−1. Time dependence of the renal clearance of theophylline was found only after i.v. administration. Dependence of the renal clearance on urine flow rate was found both after i.v. administration and at steady state, but not after a single oral dose of theophylline. After oral administration, renal clearance of theophylline was higher at steady state than after a single dose (0.58 ± 0.06 L h−1 kg−1 vs 0.23 ± 0.03 L h−1 kg−1), while urine flow rate was lower (1.1 ± 0.5 mL min−1 vs 1.8 ± 0.9 mL min−1). High correlation of theophylline plasma concentration and theophylline excretion rate was obtained in 10 of 14 patients after administration of a single oral dose of the preparation (r = 0.8567 to 0.9830). There was no dose dependence of the renal clearance of the drug either after a single dose, or at steady state. 1990 Royal Pharmaceutical Society of Great Britain",
journal = "Journal of Pharmacy and Pharmacology",
title = "Dependence of the Renal Excretion of Theophylline on its Plasma Concentrations and Urine Flow Rate in Asthmatic Children",
volume = "42",
number = "12",
pages = "827-830",
doi = "10.1111/j.2042-7158.1990.tb07034.x"
}
Agbaba, D., Pokrajac, M., Varagić, V.M.,& Pešić, V.. (1990). Dependence of the Renal Excretion of Theophylline on its Plasma Concentrations and Urine Flow Rate in Asthmatic Children. in Journal of Pharmacy and Pharmacology, 42(12), 827-830.
https://doi.org/10.1111/j.2042-7158.1990.tb07034.x
Agbaba D, Pokrajac M, Varagić V, Pešić V. Dependence of the Renal Excretion of Theophylline on its Plasma Concentrations and Urine Flow Rate in Asthmatic Children. in Journal of Pharmacy and Pharmacology. 1990;42(12):827-830.
doi:10.1111/j.2042-7158.1990.tb07034.x .
Agbaba, Danica, Pokrajac, Milena, Varagić, V.M., Pešić, V., "Dependence of the Renal Excretion of Theophylline on its Plasma Concentrations and Urine Flow Rate in Asthmatic Children" in Journal of Pharmacy and Pharmacology, 42, no. 12 (1990):827-830,
https://doi.org/10.1111/j.2042-7158.1990.tb07034.x . .
8
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Epileptic patients compliance in valproic acid therapy

Miljković, Branislava; Pokrajac, Milena; Lević, Z; Varagić, V.M.

(1990)

TY  - CONF
AU  - Miljković, Branislava
AU  - Pokrajac, Milena
AU  - Lević, Z
AU  - Varagić, V.M.
PY  - 1990
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/62
C3  - European Journal of Pharmacology
T1  - Epileptic patients compliance in valproic acid therapy
VL  - 183
IS  - 2
SP  - 518
DO  - 10.1016/0014-2999(90)93419-Q
ER  - 
@conference{
author = "Miljković, Branislava and Pokrajac, Milena and Lević, Z and Varagić, V.M.",
year = "1990",
journal = "European Journal of Pharmacology",
title = "Epileptic patients compliance in valproic acid therapy",
volume = "183",
number = "2",
pages = "518",
doi = "10.1016/0014-2999(90)93419-Q"
}
Miljković, B., Pokrajac, M., Lević, Z.,& Varagić, V.M.. (1990). Epileptic patients compliance in valproic acid therapy. in European Journal of Pharmacology, 183(2), 518.
https://doi.org/10.1016/0014-2999(90)93419-Q
Miljković B, Pokrajac M, Lević Z, Varagić V. Epileptic patients compliance in valproic acid therapy. in European Journal of Pharmacology. 1990;183(2):518.
doi:10.1016/0014-2999(90)93419-Q .
Miljković, Branislava, Pokrajac, Milena, Lević, Z, Varagić, V.M., "Epileptic patients compliance in valproic acid therapy" in European Journal of Pharmacology, 183, no. 2 (1990):518,
https://doi.org/10.1016/0014-2999(90)93419-Q . .

The possibility of measuring the salivary concentrations of theophylline in bioavailability studies

Agbaba, Danica; Pokrajac, Milena; Varagić, V.M.; Živanov-Stakić, Dobrila

(Informa Healthcare, 1988)

TY  - JOUR
AU  - Agbaba, Danica
AU  - Pokrajac, Milena
AU  - Varagić, V.M.
AU  - Živanov-Stakić, Dobrila
PY  - 1988
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/44
AB  - The possibility of using the saliva in bioavailability studies of theophylline was investigated. Plasma and saliva concentrations were determined simultaneously and corresponding pharmacokinetic parameters were calculated and compared.
PB  - Informa Healthcare
T2  - Drug Development and Industrial Pharmacy
T1  - The possibility of measuring the salivary concentrations of theophylline in bioavailability studies
VL  - 14
IS  - 15-17
SP  - 2467
EP  - 2476
DO  - 10.3109/03639048809152027
ER  - 
@article{
author = "Agbaba, Danica and Pokrajac, Milena and Varagić, V.M. and Živanov-Stakić, Dobrila",
year = "1988",
abstract = "The possibility of using the saliva in bioavailability studies of theophylline was investigated. Plasma and saliva concentrations were determined simultaneously and corresponding pharmacokinetic parameters were calculated and compared.",
publisher = "Informa Healthcare",
journal = "Drug Development and Industrial Pharmacy",
title = "The possibility of measuring the salivary concentrations of theophylline in bioavailability studies",
volume = "14",
number = "15-17",
pages = "2467-2476",
doi = "10.3109/03639048809152027"
}
Agbaba, D., Pokrajac, M., Varagić, V.M.,& Živanov-Stakić, D.. (1988). The possibility of measuring the salivary concentrations of theophylline in bioavailability studies. in Drug Development and Industrial Pharmacy
Informa Healthcare., 14(15-17), 2467-2476.
https://doi.org/10.3109/03639048809152027
Agbaba D, Pokrajac M, Varagić V, Živanov-Stakić D. The possibility of measuring the salivary concentrations of theophylline in bioavailability studies. in Drug Development and Industrial Pharmacy. 1988;14(15-17):2467-2476.
doi:10.3109/03639048809152027 .
Agbaba, Danica, Pokrajac, Milena, Varagić, V.M., Živanov-Stakić, Dobrila, "The possibility of measuring the salivary concentrations of theophylline in bioavailability studies" in Drug Development and Industrial Pharmacy, 14, no. 15-17 (1988):2467-2476,
https://doi.org/10.3109/03639048809152027 . .
1

Pharmacokinetic evaluation of a sustained release preparation of theophylline in asthmatic children and adults

Pokrajac, Milena; Agbaba, Danica; Peŝić, V; Bosnjak, V; Varagić, V.M.

(Informa Healthcare, 1988)

TY  - JOUR
AU  - Pokrajac, Milena
AU  - Agbaba, Danica
AU  - Peŝić, V
AU  - Bosnjak, V
AU  - Varagić, V.M.
PY  - 1988
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/42
AB  - A sustained release preparation of theophylline (SRP of Th) was evaluated pharmacokinetically in asthmatic children and adults and it was found to have good SR properties. Different dosage requirements for equal pharmacokinetic behaviour in these two groups have been explained by the influence of the factors which can be responsible, such as bioavailability, liver mass and free drug concentration.
PB  - Informa Healthcare
T2  - Drug Development and Industrial Pharmacy
T1  - Pharmacokinetic evaluation of a sustained release preparation of theophylline in asthmatic children and adults
VL  - 14
IS  - 15-17
SP  - 2567
EP  - 2577
DO  - 10.3109/03639048809152033
ER  - 
@article{
author = "Pokrajac, Milena and Agbaba, Danica and Peŝić, V and Bosnjak, V and Varagić, V.M.",
year = "1988",
abstract = "A sustained release preparation of theophylline (SRP of Th) was evaluated pharmacokinetically in asthmatic children and adults and it was found to have good SR properties. Different dosage requirements for equal pharmacokinetic behaviour in these two groups have been explained by the influence of the factors which can be responsible, such as bioavailability, liver mass and free drug concentration.",
publisher = "Informa Healthcare",
journal = "Drug Development and Industrial Pharmacy",
title = "Pharmacokinetic evaluation of a sustained release preparation of theophylline in asthmatic children and adults",
volume = "14",
number = "15-17",
pages = "2567-2577",
doi = "10.3109/03639048809152033"
}
Pokrajac, M., Agbaba, D., Peŝić, V., Bosnjak, V.,& Varagić, V.M.. (1988). Pharmacokinetic evaluation of a sustained release preparation of theophylline in asthmatic children and adults. in Drug Development and Industrial Pharmacy
Informa Healthcare., 14(15-17), 2567-2577.
https://doi.org/10.3109/03639048809152033
Pokrajac M, Agbaba D, Peŝić V, Bosnjak V, Varagić V. Pharmacokinetic evaluation of a sustained release preparation of theophylline in asthmatic children and adults. in Drug Development and Industrial Pharmacy. 1988;14(15-17):2567-2577.
doi:10.3109/03639048809152033 .
Pokrajac, Milena, Agbaba, Danica, Peŝić, V, Bosnjak, V, Varagić, V.M., "Pharmacokinetic evaluation of a sustained release preparation of theophylline in asthmatic children and adults" in Drug Development and Industrial Pharmacy, 14, no. 15-17 (1988):2567-2577,
https://doi.org/10.3109/03639048809152033 . .

Pharmacokinetics of a sustained release preparation of theophylline in asthmatic children

Pokrajac, Milena; Agbaba, Danica; Pešić, Vesna; Varagić, V.M.

(1987)

TY  - JOUR
AU  - Pokrajac, Milena
AU  - Agbaba, Danica
AU  - Pešić, Vesna
AU  - Varagić, V.M.
PY  - 1987
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/29
T2  - Acta Pharmaceutica Jugoslavica
T1  - Pharmacokinetics of a sustained release preparation of theophylline in asthmatic children
VL  - 37
IS  - 4
SP  - 353
EP  - 360
UR  - https://hdl.handle.net/21.15107/rcub_farfar_29
ER  - 
@article{
author = "Pokrajac, Milena and Agbaba, Danica and Pešić, Vesna and Varagić, V.M.",
year = "1987",
journal = "Acta Pharmaceutica Jugoslavica",
title = "Pharmacokinetics of a sustained release preparation of theophylline in asthmatic children",
volume = "37",
number = "4",
pages = "353-360",
url = "https://hdl.handle.net/21.15107/rcub_farfar_29"
}
Pokrajac, M., Agbaba, D., Pešić, V.,& Varagić, V.M.. (1987). Pharmacokinetics of a sustained release preparation of theophylline in asthmatic children. in Acta Pharmaceutica Jugoslavica, 37(4), 353-360.
https://hdl.handle.net/21.15107/rcub_farfar_29
Pokrajac M, Agbaba D, Pešić V, Varagić V. Pharmacokinetics of a sustained release preparation of theophylline in asthmatic children. in Acta Pharmaceutica Jugoslavica. 1987;37(4):353-360.
https://hdl.handle.net/21.15107/rcub_farfar_29 .
Pokrajac, Milena, Agbaba, Danica, Pešić, Vesna, Varagić, V.M., "Pharmacokinetics of a sustained release preparation of theophylline in asthmatic children" in Acta Pharmaceutica Jugoslavica, 37, no. 4 (1987):353-360,
https://hdl.handle.net/21.15107/rcub_farfar_29 .

The comparison of the spectrodensitometric determination of theophylline to HPLC, RIA and EMIT procedures

Pokrajac, Milena; Agbaba, Danica; Varagić, V.M.; Glisović, L

(1986)

TY  - JOUR
AU  - Pokrajac, Milena
AU  - Agbaba, Danica
AU  - Varagić, V.M.
AU  - Glisović, L
PY  - 1986
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/23
T2  - Acta Pharmaceutica Jugoslavica
T1  - The comparison of the spectrodensitometric determination of theophylline to HPLC, RIA and EMIT procedures
VL  - 36
IS  - 4
SP  - 445
EP  - 453
UR  - https://hdl.handle.net/21.15107/rcub_farfar_23
ER  - 
@article{
author = "Pokrajac, Milena and Agbaba, Danica and Varagić, V.M. and Glisović, L",
year = "1986",
journal = "Acta Pharmaceutica Jugoslavica",
title = "The comparison of the spectrodensitometric determination of theophylline to HPLC, RIA and EMIT procedures",
volume = "36",
number = "4",
pages = "445-453",
url = "https://hdl.handle.net/21.15107/rcub_farfar_23"
}
Pokrajac, M., Agbaba, D., Varagić, V.M.,& Glisović, L.. (1986). The comparison of the spectrodensitometric determination of theophylline to HPLC, RIA and EMIT procedures. in Acta Pharmaceutica Jugoslavica, 36(4), 445-453.
https://hdl.handle.net/21.15107/rcub_farfar_23
Pokrajac M, Agbaba D, Varagić V, Glisović L. The comparison of the spectrodensitometric determination of theophylline to HPLC, RIA and EMIT procedures. in Acta Pharmaceutica Jugoslavica. 1986;36(4):445-453.
https://hdl.handle.net/21.15107/rcub_farfar_23 .
Pokrajac, Milena, Agbaba, Danica, Varagić, V.M., Glisović, L, "The comparison of the spectrodensitometric determination of theophylline to HPLC, RIA and EMIT procedures" in Acta Pharmaceutica Jugoslavica, 36, no. 4 (1986):445-453,
https://hdl.handle.net/21.15107/rcub_farfar_23 .
6