TY  - JOUR
AU  - Buha, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Moulis, Jean-Marc
AU  - Goumenou, Marina
AU  - Wallace, David
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3659
AB  - Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of "hyperglycemic" metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance.
PB  - MDPI AG
T2  - Toxics
T1  - Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data
VL  - 8
IS  - 3
DO  - 10.3390/TOXICS8030063
ER  - 

@article{
author = "Buha, Aleksandra and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Moulis, Jean-Marc and Goumenou, Marina and Wallace, David",
year = "2020",
abstract = "Recent research has helped clarify the role of cadmium (Cd) in various pathological states. We have demonstrated Cd involvement in pancreatic cancer, as well as the bioaccumulation of Cd in the pancreas. Bioaccumulation and increased toxicity suggest that Cd may also be involved in other pancreas-mediated diseases, like diabetes. Cd falls into the category of "hyperglycemic" metals, i.e., metals that increase blood glucose levels, which could be due to increased gluconeogenesis, damage to β-cells leading to reduced insulin production, or insulin resistance at target tissue resulting in a lack of glucose uptake. This review addresses the current evidence for the role of Cd, leading to insulin resistance from human, animal, and in vitro studies. Available data have shown that Cd may affect normal insulin function through multiple pathways. There is evidence that Cd exposure results in the perturbation of the enzymes and modulatory proteins involved in insulin signal transduction at the target tissue and mutations of the insulin receptor. Cd, through well-described mechanisms of oxidative stress, inflammation, and mitochondrial damage, may also alter insulin production in β-cells. More work is necessary to elucidate the mechanisms associated with Cd-mediated insulin resistance.",
publisher = "MDPI AG",
journal = "Toxics",
title = "Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data",
volume = "8",
number = "3",
doi = "10.3390/TOXICS8030063"
}

Buha, A., Đukić-Ćosić, D., Ćurčić, M., Bulat, Z., Antonijević, B., Moulis, J., Goumenou, M.,& Wallace, D.. (2020). Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data. in Toxics
MDPI AG., 8(3).
https://doi.org/10.3390/TOXICS8030063

Buha A, Đukić-Ćosić D, Ćurčić M, Bulat Z, Antonijević B, Moulis J, Goumenou M, Wallace D. Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data. in Toxics. 2020;8(3).
doi:10.3390/TOXICS8030063 .

Buha, Aleksandra, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Moulis, Jean-Marc, Goumenou, Marina, Wallace, David, "Emerging links between cadmium exposure and insulin resistance: Human, animal, and cell study data" in Toxics, 8, no. 3 (2020),
https://doi.org/10.3390/TOXICS8030063 . .

TY  - JOUR
AU  - Renieri, Elisavet A.
AU  - Goumenou, Marina
AU  - Kardonsky, Dmitry A.
AU  - Veselov, Valery V.
AU  - Alegakis, Athanasios K.
AU  - Buha, Aleksandra
AU  - Tzatzarakis, Manolis N.
AU  - Nosyrev, Alexander E.
AU  - Rakitskii, Valerii N.
AU  - Kentouri, Maroudio
AU  - Tsatsakis, Aristidis
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3371
AB  - Health benefits of fish consumption could be counterbalanced by the intake of contaminants after long term fish consumption, burdened even in trace levels. The presence of the indicator PCBs (NDL-PCBs and PCB 118) in farmed and wild seabream and seabass was evaluated. For the determination of PCB, a GC-MS method was developed and evaluated. The association of PCB accumulation in fish with seasonality, locality, production mode and species was also investigated. A new approach for the risk characterisation after exposure to NDL-PCB through fish consumption in Greece was developed, based on the real exposure and the permitted maximum levels of both aggregated dietary exposure and exposure through fish consumption. PCB levels determined in fish were below established permitted limits (6.24 ng/g 95th percentile), while PCB levels and congener distribution varied significantly between farmed and wild fish (p = 0.001). Seasonality was highlighted as an important factor affecting NDL-PCBs accumulation, with high levels coinciding with the reproduction period of each species. Differences were also depicted for sampling sites, with PCB 118 presenting significantly higher values in open seas while NDL-PCB congeners in closed seas. Risk assessment of NDL-PCB intake through fish consumption corrected for the aggregated exposure revealed no risk for the consumers.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Food and Chemical Toxicology
T1  - Indicator PCBs in farmed and wild fish in Greece - Risk assessment for the Greek population
VL  - 127
SP  - 260
EP  - 269
DO  - 10.1016/j.fct.2019.03.027
ER  - 

@article{
author = "Renieri, Elisavet A. and Goumenou, Marina and Kardonsky, Dmitry A. and Veselov, Valery V. and Alegakis, Athanasios K. and Buha, Aleksandra and Tzatzarakis, Manolis N. and Nosyrev, Alexander E. and Rakitskii, Valerii N. and Kentouri, Maroudio and Tsatsakis, Aristidis",
year = "2019",
abstract = "Health benefits of fish consumption could be counterbalanced by the intake of contaminants after long term fish consumption, burdened even in trace levels. The presence of the indicator PCBs (NDL-PCBs and PCB 118) in farmed and wild seabream and seabass was evaluated. For the determination of PCB, a GC-MS method was developed and evaluated. The association of PCB accumulation in fish with seasonality, locality, production mode and species was also investigated. A new approach for the risk characterisation after exposure to NDL-PCB through fish consumption in Greece was developed, based on the real exposure and the permitted maximum levels of both aggregated dietary exposure and exposure through fish consumption. PCB levels determined in fish were below established permitted limits (6.24 ng/g 95th percentile), while PCB levels and congener distribution varied significantly between farmed and wild fish (p = 0.001). Seasonality was highlighted as an important factor affecting NDL-PCBs accumulation, with high levels coinciding with the reproduction period of each species. Differences were also depicted for sampling sites, with PCB 118 presenting significantly higher values in open seas while NDL-PCB congeners in closed seas. Risk assessment of NDL-PCB intake through fish consumption corrected for the aggregated exposure revealed no risk for the consumers.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Food and Chemical Toxicology",
title = "Indicator PCBs in farmed and wild fish in Greece - Risk assessment for the Greek population",
volume = "127",
pages = "260-269",
doi = "10.1016/j.fct.2019.03.027"
}

Renieri, E. A., Goumenou, M., Kardonsky, D. A., Veselov, V. V., Alegakis, A. K., Buha, A., Tzatzarakis, M. N., Nosyrev, A. E., Rakitskii, V. N., Kentouri, M.,& Tsatsakis, A.. (2019). Indicator PCBs in farmed and wild fish in Greece - Risk assessment for the Greek population. in Food and Chemical Toxicology
Pergamon-Elsevier Science Ltd, Oxford., 127, 260-269.
https://doi.org/10.1016/j.fct.2019.03.027

Renieri EA, Goumenou M, Kardonsky DA, Veselov VV, Alegakis AK, Buha A, Tzatzarakis MN, Nosyrev AE, Rakitskii VN, Kentouri M, Tsatsakis A. Indicator PCBs in farmed and wild fish in Greece - Risk assessment for the Greek population. in Food and Chemical Toxicology. 2019;127:260-269.
doi:10.1016/j.fct.2019.03.027 .

Renieri, Elisavet A., Goumenou, Marina, Kardonsky, Dmitry A., Veselov, Valery V., Alegakis, Athanasios K., Buha, Aleksandra, Tzatzarakis, Manolis N., Nosyrev, Alexander E., Rakitskii, Valerii N., Kentouri, Maroudio, Tsatsakis, Aristidis, "Indicator PCBs in farmed and wild fish in Greece - Risk assessment for the Greek population" in Food and Chemical Toxicology, 127 (2019):260-269,
https://doi.org/10.1016/j.fct.2019.03.027 . .