TY  - JOUR
AU  - Novaković, Aleksandra
AU  - Pavlović, Marija
AU  - Milojević, Predrag
AU  - Stojanović, Ivan
AU  - Nenezić, Dragoslav
AU  - Jović, Miomir
AU  - Ugrešić, Nenad
AU  - Kanjuh, Vladimir
AU  - Yang, Qin
AU  - He, Guo-Wei
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1731
AB  - The ATP-sensitive K+ channels opener (KATPCO), P1075 [N-cyano-N'-(1,1-dimethylpropyl)-N?-3-pyridylguanidine], has been shown to cause relaxation of various isolated animal and human blood vessels by opening of vascular smooth muscle ATP-sensitive K+ (KATP) channels. In addition to the well-known effect on the opening of KATP channels, it has been reported that vasorelaxation induced by some of the KATPCOs includes some other K+ channel subtypes. Given that there is still no information on other types of K+ channels possibly involved in the mechanism of relaxation induced by P1075, this study was designed to examine the effects of P1075 on the rat renal artery with endothelium and with denuded endothelium and to define the contribution of different K+ channel subtypes in the P1075 action on this blood vessel. Our results show that P1075 induced a concentration-dependent relaxation of rat renal artery rings pre-contracted by phenylephrine. Glibenclamide, a selective KATP channels inhibitor, partly antagonized the relaxation of rat renal artery induced by P1075. Tetraethylammonium (TEA), a non-selective inhibitor of Ca2+-activated K+ channels, as well as iberiotoxin, a most selective blocker of large-conductance Ca2+-activated K+ (BKCa) channels, did not abolish the effect of P1075 on rat renal artery. In contrast, a non-selective blocker of voltage-gated K+ (KV) channels, 4-aminopyridine (4-AP), as well as margatoxin, a potent inhibitor of KV1.3 channels, caused partial inhibition of the P1075-induced relaxation of rat renal artery. In addition, in this study, P1075 relaxed contractions induced by 20 similar to mM K+, but had no effect on contractions induced by 80 similar to mM K+. Our results showed that P1075 induced strong endothelium-independent relaxation of rat renal artery. It seems that KATP, 4-AP- and margatoxin-sensitive K+ channels located in vascular smooth muscle mediated the relaxation of rat renal artery induced by P1075.
PB  - Wiley, Hoboken
T2  - Basic & Clinical Pharmacology & Toxicology
T1  - Different Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075
VL  - 111
IS  - 1
SP  - 24
EP  - 30
DO  - 10.1111/j.1742-7843.2011.00855.x
ER  - 

@article{
author = "Novaković, Aleksandra and Pavlović, Marija and Milojević, Predrag and Stojanović, Ivan and Nenezić, Dragoslav and Jović, Miomir and Ugrešić, Nenad and Kanjuh, Vladimir and Yang, Qin and He, Guo-Wei",
year = "2012",
abstract = "The ATP-sensitive K+ channels opener (KATPCO), P1075 [N-cyano-N'-(1,1-dimethylpropyl)-N?-3-pyridylguanidine], has been shown to cause relaxation of various isolated animal and human blood vessels by opening of vascular smooth muscle ATP-sensitive K+ (KATP) channels. In addition to the well-known effect on the opening of KATP channels, it has been reported that vasorelaxation induced by some of the KATPCOs includes some other K+ channel subtypes. Given that there is still no information on other types of K+ channels possibly involved in the mechanism of relaxation induced by P1075, this study was designed to examine the effects of P1075 on the rat renal artery with endothelium and with denuded endothelium and to define the contribution of different K+ channel subtypes in the P1075 action on this blood vessel. Our results show that P1075 induced a concentration-dependent relaxation of rat renal artery rings pre-contracted by phenylephrine. Glibenclamide, a selective KATP channels inhibitor, partly antagonized the relaxation of rat renal artery induced by P1075. Tetraethylammonium (TEA), a non-selective inhibitor of Ca2+-activated K+ channels, as well as iberiotoxin, a most selective blocker of large-conductance Ca2+-activated K+ (BKCa) channels, did not abolish the effect of P1075 on rat renal artery. In contrast, a non-selective blocker of voltage-gated K+ (KV) channels, 4-aminopyridine (4-AP), as well as margatoxin, a potent inhibitor of KV1.3 channels, caused partial inhibition of the P1075-induced relaxation of rat renal artery. In addition, in this study, P1075 relaxed contractions induced by 20 similar to mM K+, but had no effect on contractions induced by 80 similar to mM K+. Our results showed that P1075 induced strong endothelium-independent relaxation of rat renal artery. It seems that KATP, 4-AP- and margatoxin-sensitive K+ channels located in vascular smooth muscle mediated the relaxation of rat renal artery induced by P1075.",
publisher = "Wiley, Hoboken",
journal = "Basic & Clinical Pharmacology & Toxicology",
title = "Different Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075",
volume = "111",
number = "1",
pages = "24-30",
doi = "10.1111/j.1742-7843.2011.00855.x"
}

Novaković, A., Pavlović, M., Milojević, P., Stojanović, I., Nenezić, D., Jović, M., Ugrešić, N., Kanjuh, V., Yang, Q.,& He, G.. (2012). Different Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075. in Basic & Clinical Pharmacology & Toxicology
Wiley, Hoboken., 111(1), 24-30.
https://doi.org/10.1111/j.1742-7843.2011.00855.x

Novaković A, Pavlović M, Milojević P, Stojanović I, Nenezić D, Jović M, Ugrešić N, Kanjuh V, Yang Q, He G. Different Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075. in Basic & Clinical Pharmacology & Toxicology. 2012;111(1):24-30.
doi:10.1111/j.1742-7843.2011.00855.x .

Novaković, Aleksandra, Pavlović, Marija, Milojević, Predrag, Stojanović, Ivan, Nenezić, Dragoslav, Jović, Miomir, Ugrešić, Nenad, Kanjuh, Vladimir, Yang, Qin, He, Guo-Wei, "Different Potassium Channels are Involved in Relaxation of Rat Renal Artery Induced by P1075" in Basic & Clinical Pharmacology & Toxicology, 111, no. 1 (2012):24-30,
https://doi.org/10.1111/j.1742-7843.2011.00855.x . .

TY  - JOUR
AU  - Nikolić, Katarina
AU  - Pavlović, Marija
AU  - Smolinski, Adam
AU  - Agbaba, Danica
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1670
AB  - Optimization of the experimental conditions of a novel HPLC method for determination of the impurity levels with ziprasidone (in bulk substance and pharmaceutical dosage forms) was performed with use of Multi-Layer Perceptron (MLP) Artificial Neural Networks (ANN) and Response Surface Plots. The obtained experimental conditions were further used to test a set of 20 reversed-phase columns for their selectivity towards ziprasidone components by use of the principal component analysis (PCA) and hierarchical clustering analysis (HCA). The obtained HPLC retention times of ziprasidone and its impurities (Imp I-V) along with the computed molecular parameters of the examined compounds were further used in the Quantitative Structure Retention Relationship (QSRR) study. The performed QSRR study has selected the LogD(pH) (1.5), LogD(pH 2.5), LogD(pH 4.0), LogP, MS, and SAS parameters as descriptors of the chromatographic behavior of ziprasidone components. The developed QSRR model can be very useful in the t(R) prediction for the ziprasidone derivatives (impurities, degradation products, and metabolites). As the performed LC-MS study of the test solution has confirmed that the unknown impurity (t(R): 11.270 min) in the test solution is the TS1, one from two candidates predicted by QSRR (TS1 and TS5), the high prediction potential of the created QSRR models has been proved.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Combinatorial Chemistry & High Throughput Screening
T1  - The Chemometric Study and Quantitative Structure Retention Relationship Modeling of Liquid Chromatography Separation of Ziprasidone Components
VL  - 15
IS  - 9
SP  - 730
EP  - 744
DO  - 10.2174/138620712803519699
ER  - 

@article{
author = "Nikolić, Katarina and Pavlović, Marija and Smolinski, Adam and Agbaba, Danica",
year = "2012",
abstract = "Optimization of the experimental conditions of a novel HPLC method for determination of the impurity levels with ziprasidone (in bulk substance and pharmaceutical dosage forms) was performed with use of Multi-Layer Perceptron (MLP) Artificial Neural Networks (ANN) and Response Surface Plots. The obtained experimental conditions were further used to test a set of 20 reversed-phase columns for their selectivity towards ziprasidone components by use of the principal component analysis (PCA) and hierarchical clustering analysis (HCA). The obtained HPLC retention times of ziprasidone and its impurities (Imp I-V) along with the computed molecular parameters of the examined compounds were further used in the Quantitative Structure Retention Relationship (QSRR) study. The performed QSRR study has selected the LogD(pH) (1.5), LogD(pH 2.5), LogD(pH 4.0), LogP, MS, and SAS parameters as descriptors of the chromatographic behavior of ziprasidone components. The developed QSRR model can be very useful in the t(R) prediction for the ziprasidone derivatives (impurities, degradation products, and metabolites). As the performed LC-MS study of the test solution has confirmed that the unknown impurity (t(R): 11.270 min) in the test solution is the TS1, one from two candidates predicted by QSRR (TS1 and TS5), the high prediction potential of the created QSRR models has been proved.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Combinatorial Chemistry & High Throughput Screening",
title = "The Chemometric Study and Quantitative Structure Retention Relationship Modeling of Liquid Chromatography Separation of Ziprasidone Components",
volume = "15",
number = "9",
pages = "730-744",
doi = "10.2174/138620712803519699"
}

Nikolić, K., Pavlović, M., Smolinski, A.,& Agbaba, D.. (2012). The Chemometric Study and Quantitative Structure Retention Relationship Modeling of Liquid Chromatography Separation of Ziprasidone Components. in Combinatorial Chemistry & High Throughput Screening
Bentham Science Publ Ltd, Sharjah., 15(9), 730-744.
https://doi.org/10.2174/138620712803519699

Nikolić K, Pavlović M, Smolinski A, Agbaba D. The Chemometric Study and Quantitative Structure Retention Relationship Modeling of Liquid Chromatography Separation of Ziprasidone Components. in Combinatorial Chemistry & High Throughput Screening. 2012;15(9):730-744.
doi:10.2174/138620712803519699 .

Nikolić, Katarina, Pavlović, Marija, Smolinski, Adam, Agbaba, Danica, "The Chemometric Study and Quantitative Structure Retention Relationship Modeling of Liquid Chromatography Separation of Ziprasidone Components" in Combinatorial Chemistry & High Throughput Screening, 15, no. 9 (2012):730-744,
https://doi.org/10.2174/138620712803519699 . .

TY  - JOUR
AU  - Pavlović, Marija
AU  - Malešević, Marija
AU  - Nikolić, Katarina
AU  - Agbaba, Danica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1561
AB  - Ziprasidone is known as a novel "atypical" or "second-generation" antipsychotic drug. A sensitive and reproducible method was developed and validated for determination of ziprasidone and its major impurities, which are significantly different in polarity. The separation is performed on a Waters Spherisorb (R) octadecylsilyl 1 column (5.0 mu m particle size, 250 x 4.6 mm id) using a gradient with mobile phase A [buffer acetonitrile (80+20, v/v)] and mobile phase B [buffer acetonitrile (10+90, v/v)] at a working temperature of 25 degrees C. The buffer was 0.05 M KH(2)PO(4) solution with an addition of 10 mL triethylamine/L solution, adjusted to pH 2.5 with orthophosphoric acid. The flow rate was 1.5 mL/min, and the eluate was monitored at 250 nm using a diode array detector. Optimization of the experimental conditions was performed using partial least squares regression, for which four factors were selected for optimization: buffer concentration, buffer pH, triethylamine concentration, and temperature. The proposed validated method is convenient and reliable for the assay and purity control in both raw materials and dosage forms.
PB  - AOAC Int, Gaithersburg
T2  - Journal of AOAC International
T1  - Development and Validation of an HPLC Method for Determination of Ziprasidone and Its Impurities in Pharmaceutical Dosage Forms
VL  - 94
IS  - 3
SP  - 713
EP  - 722
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1561
ER  - 

@article{
author = "Pavlović, Marija and Malešević, Marija and Nikolić, Katarina and Agbaba, Danica",
year = "2011",
abstract = "Ziprasidone is known as a novel "atypical" or "second-generation" antipsychotic drug. A sensitive and reproducible method was developed and validated for determination of ziprasidone and its major impurities, which are significantly different in polarity. The separation is performed on a Waters Spherisorb (R) octadecylsilyl 1 column (5.0 mu m particle size, 250 x 4.6 mm id) using a gradient with mobile phase A [buffer acetonitrile (80+20, v/v)] and mobile phase B [buffer acetonitrile (10+90, v/v)] at a working temperature of 25 degrees C. The buffer was 0.05 M KH(2)PO(4) solution with an addition of 10 mL triethylamine/L solution, adjusted to pH 2.5 with orthophosphoric acid. The flow rate was 1.5 mL/min, and the eluate was monitored at 250 nm using a diode array detector. Optimization of the experimental conditions was performed using partial least squares regression, for which four factors were selected for optimization: buffer concentration, buffer pH, triethylamine concentration, and temperature. The proposed validated method is convenient and reliable for the assay and purity control in both raw materials and dosage forms.",
publisher = "AOAC Int, Gaithersburg",
journal = "Journal of AOAC International",
title = "Development and Validation of an HPLC Method for Determination of Ziprasidone and Its Impurities in Pharmaceutical Dosage Forms",
volume = "94",
number = "3",
pages = "713-722",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1561"
}

Pavlović, M., Malešević, M., Nikolić, K.,& Agbaba, D.. (2011). Development and Validation of an HPLC Method for Determination of Ziprasidone and Its Impurities in Pharmaceutical Dosage Forms. in Journal of AOAC International
AOAC Int, Gaithersburg., 94(3), 713-722.
https://hdl.handle.net/21.15107/rcub_farfar_1561

Pavlović M, Malešević M, Nikolić K, Agbaba D. Development and Validation of an HPLC Method for Determination of Ziprasidone and Its Impurities in Pharmaceutical Dosage Forms. in Journal of AOAC International. 2011;94(3):713-722.
https://hdl.handle.net/21.15107/rcub_farfar_1561 .

Pavlović, Marija, Malešević, Marija, Nikolić, Katarina, Agbaba, Danica, "Development and Validation of an HPLC Method for Determination of Ziprasidone and Its Impurities in Pharmaceutical Dosage Forms" in Journal of AOAC International, 94, no. 3 (2011):713-722,
https://hdl.handle.net/21.15107/rcub_farfar_1561 .