TY  - JOUR
AU  - Marinković, Valentina
AU  - Agbaba, Danica
AU  - Karljiković-Rajić, Katarina
AU  - Comor, J
AU  - Živanov-Stakić, Dobrila
PY  - 2000
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/239
AB  - The photodecomposition of nisoldipine ((+/-)3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate), whereby its 4-(2-nitrosophenyl) pyridine analogue is obtained as the photolytic product, was investigated under daylight exposure by means of UV derivative spectrophotometry. The optimal instrumental parameters (120 nm/min scan speed: 2 nm slit width; Delta lambda = 10 nm and 5 s response time) for analogue derivative spectra were established for amplitudes D-1(285) and D-2(291) (measured to the baseline) of the nitroso analogue assay, as well as for D-1(386) of the parent compound-nisoldipine assay. Using the first-order derivative spectrum, the minimum detectable amount of nitroso analogue in the presence of nisoldipine was equivalent to an impurity level of 5% and by the second-order derivative spectrum, the determination limit was equivalent to an impurity level of 2%. The degradation of nisoldipine followed within 30 days and the calculated maximal degradation rate was 1.6% per day for nisoldipine raw material, but significantly lower values of 0.19 and 0.15% per day were obtained for Nisoldin(R) tablets (10 and 5 mg, respectively).
PB  - Elsevier Science Sa, Lausanne
T2  - Farmaco
T1  - UV derivative spectrophotometric study of the photochemical degradation of nisoldipine
VL  - 55
IS  - 2
SP  - 128
EP  - 133
DO  - 10.1016/S0014-827X(00)00004-5
ER  - 

@article{
author = "Marinković, Valentina and Agbaba, Danica and Karljiković-Rajić, Katarina and Comor, J and Živanov-Stakić, Dobrila",
year = "2000",
abstract = "The photodecomposition of nisoldipine ((+/-)3-isobutyl-5-methyl-1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-dicarboxylate), whereby its 4-(2-nitrosophenyl) pyridine analogue is obtained as the photolytic product, was investigated under daylight exposure by means of UV derivative spectrophotometry. The optimal instrumental parameters (120 nm/min scan speed: 2 nm slit width; Delta lambda = 10 nm and 5 s response time) for analogue derivative spectra were established for amplitudes D-1(285) and D-2(291) (measured to the baseline) of the nitroso analogue assay, as well as for D-1(386) of the parent compound-nisoldipine assay. Using the first-order derivative spectrum, the minimum detectable amount of nitroso analogue in the presence of nisoldipine was equivalent to an impurity level of 5% and by the second-order derivative spectrum, the determination limit was equivalent to an impurity level of 2%. The degradation of nisoldipine followed within 30 days and the calculated maximal degradation rate was 1.6% per day for nisoldipine raw material, but significantly lower values of 0.19 and 0.15% per day were obtained for Nisoldin(R) tablets (10 and 5 mg, respectively).",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Farmaco",
title = "UV derivative spectrophotometric study of the photochemical degradation of nisoldipine",
volume = "55",
number = "2",
pages = "128-133",
doi = "10.1016/S0014-827X(00)00004-5"
}

Marinković, V., Agbaba, D., Karljiković-Rajić, K., Comor, J.,& Živanov-Stakić, D.. (2000). UV derivative spectrophotometric study of the photochemical degradation of nisoldipine. in Farmaco
Elsevier Science Sa, Lausanne., 55(2), 128-133.
https://doi.org/10.1016/S0014-827X(00)00004-5

Marinković V, Agbaba D, Karljiković-Rajić K, Comor J, Živanov-Stakić D. UV derivative spectrophotometric study of the photochemical degradation of nisoldipine. in Farmaco. 2000;55(2):128-133.
doi:10.1016/S0014-827X(00)00004-5 .

Marinković, Valentina, Agbaba, Danica, Karljiković-Rajić, Katarina, Comor, J, Živanov-Stakić, Dobrila, "UV derivative spectrophotometric study of the photochemical degradation of nisoldipine" in Farmaco, 55, no. 2 (2000):128-133,
https://doi.org/10.1016/S0014-827X(00)00004-5 . .