TY  - JOUR
AU  - Vučinić, Slavica
AU  - Zlatković, Milica
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Bošković, Bogdan
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1966
AB  - Despite improvements to intensive care management and specific pharmacological treatments (atropine, oxime, diazepam), the mortality associated with organophosphate (OP) poisoning has not substantially decreased. The objective of this examination was to describe the role of fresh frozen plasma (FFP) in acute OP poisoning. After a deliberate ingestion of malathion, a 55-year-old male suffering from miosis, somnolence, bradycardia, muscular fasciculations, rales on auscultation, respiratory insufficiency, as well as from an inhibition of red blood cell acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BuChE), was admitted to hospital. Malathion was confirmed in a concentration of 18.01 mg L-1. Apart from supportive measures (including mechanical ventilation for four days), antidotal treatment with atropine, oxime - pralidoxime methylsulphate (Contrathion (R)), and diazepam was administered, along with FFP. The potentially beneficial effects of FFP therapy included a prompt increase of BuChE activity (from 926 IU L-1 to 3277 IU L-1; reference range from 7000 IU L-1 to 19000 IU L-1) and a reduction in the malathion concentration, followed by clinical recovery. Due to BuChE replacement, albumin content, and volume restitution, FFP treatment may be used as an alternative approach in patients with acute OP poisoning, especially when oximes are not available.
PB  - Inst Medical Research & Occupational Health, Zagreb
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Fresh frozen plasma as a successful antidotal supplement in acute organophosphate poisoning
VL  - 64
IS  - 2
SP  - 273
EP  - 277
DO  - 10.2478/10004-1254-64-2013-2378
ER  - 

@article{
author = "Vučinić, Slavica and Zlatković, Milica and Antonijević, Biljana and Ćurčić, Marijana and Bošković, Bogdan",
year = "2013",
abstract = "Despite improvements to intensive care management and specific pharmacological treatments (atropine, oxime, diazepam), the mortality associated with organophosphate (OP) poisoning has not substantially decreased. The objective of this examination was to describe the role of fresh frozen plasma (FFP) in acute OP poisoning. After a deliberate ingestion of malathion, a 55-year-old male suffering from miosis, somnolence, bradycardia, muscular fasciculations, rales on auscultation, respiratory insufficiency, as well as from an inhibition of red blood cell acetylcholinesterase (AChE) and plasma butyrylcholinesterase (BuChE), was admitted to hospital. Malathion was confirmed in a concentration of 18.01 mg L-1. Apart from supportive measures (including mechanical ventilation for four days), antidotal treatment with atropine, oxime - pralidoxime methylsulphate (Contrathion (R)), and diazepam was administered, along with FFP. The potentially beneficial effects of FFP therapy included a prompt increase of BuChE activity (from 926 IU L-1 to 3277 IU L-1; reference range from 7000 IU L-1 to 19000 IU L-1) and a reduction in the malathion concentration, followed by clinical recovery. Due to BuChE replacement, albumin content, and volume restitution, FFP treatment may be used as an alternative approach in patients with acute OP poisoning, especially when oximes are not available.",
publisher = "Inst Medical Research & Occupational Health, Zagreb",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Fresh frozen plasma as a successful antidotal supplement in acute organophosphate poisoning",
volume = "64",
number = "2",
pages = "273-277",
doi = "10.2478/10004-1254-64-2013-2378"
}

Vučinić, S., Zlatković, M., Antonijević, B., Ćurčić, M.,& Bošković, B.. (2013). Fresh frozen plasma as a successful antidotal supplement in acute organophosphate poisoning. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Inst Medical Research & Occupational Health, Zagreb., 64(2), 273-277.
https://doi.org/10.2478/10004-1254-64-2013-2378

Vučinić S, Zlatković M, Antonijević B, Ćurčić M, Bošković B. Fresh frozen plasma as a successful antidotal supplement in acute organophosphate poisoning. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2013;64(2):273-277.
doi:10.2478/10004-1254-64-2013-2378 .

Vučinić, Slavica, Zlatković, Milica, Antonijević, Biljana, Ćurčić, Marijana, Bošković, Bogdan, "Fresh frozen plasma as a successful antidotal supplement in acute organophosphate poisoning" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 64, no. 2 (2013):273-277,
https://doi.org/10.2478/10004-1254-64-2013-2378 . .