TY  - JOUR
AU  - Bjelobrk, Marija
AU  - Lakočević, Milan
AU  - Damjanović, Svetozar
AU  - Petakov, Milan
AU  - Petrović, Milan
AU  - Bosnić, Zoran
AU  - Arena, Ross
AU  - Popović, Dejana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3930
AB  - Background: Understanding the basis of the phenotypic variation in Gaucher's disease (GD) has proven to be challenging for efficient treatment. The current study examined cardiopulmonary characteristics of patients with GD type 1. Methods: Twenty Caucasian subjects (8/20 female) with diagnosed GD type I (GD-S) and 20 age- and sex-matched healthy controls (C), were assessed (mean age GD-S: 32.6 ± 13.1 vs. C: 36.2 ± 10.6, p >.05) before the initiation of treatment. Standard echocardiography at rest was used to assess left ventricular ejection fraction (LVEF) and pulmonary artery systolic pressure (PASP). Cardiopulmonary exercise testing (CPET) was performed on a recumbent ergometer using a ramp protocol. Results: LVEF was similar in both groups (GD-S: 65.1 ± 5.2% vs. C: 65.2 ± 5.2%, p >.05), as well as PAPS (24.1 ± 4.2 mmHg vs. C: 25.5 ± 1.3 mmHg, p >.05). GD-S had lower weight (p <.05) and worse CPET responses compared to C, including peak values of heart rate, oxygen consumption, carbondioxide production (VCO2), end-tidal pressure of CO2, and O2 pulse, as well as HR reserve after 3 min of recovery and the minute ventilation/VCO2 slope. Conclusions: Patients with GD type I have an abnormal CPET response compared to healthy controls likely due to the complex pathophysiologic process in GD that impacts multiple systems integral to the physiologic response to exercise.
PB  - John Wiley and Sons Inc
T2  - Molecular Genetics and Genomic Medicine
T1  - Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I
VL  - 9
IS  - 8
DO  - 10.1002/mgg3.1757
ER  - 

@article{
author = "Bjelobrk, Marija and Lakočević, Milan and Damjanović, Svetozar and Petakov, Milan and Petrović, Milan and Bosnić, Zoran and Arena, Ross and Popović, Dejana",
year = "2021",
abstract = "Background: Understanding the basis of the phenotypic variation in Gaucher's disease (GD) has proven to be challenging for efficient treatment. The current study examined cardiopulmonary characteristics of patients with GD type 1. Methods: Twenty Caucasian subjects (8/20 female) with diagnosed GD type I (GD-S) and 20 age- and sex-matched healthy controls (C), were assessed (mean age GD-S: 32.6 ± 13.1 vs. C: 36.2 ± 10.6, p >.05) before the initiation of treatment. Standard echocardiography at rest was used to assess left ventricular ejection fraction (LVEF) and pulmonary artery systolic pressure (PASP). Cardiopulmonary exercise testing (CPET) was performed on a recumbent ergometer using a ramp protocol. Results: LVEF was similar in both groups (GD-S: 65.1 ± 5.2% vs. C: 65.2 ± 5.2%, p >.05), as well as PAPS (24.1 ± 4.2 mmHg vs. C: 25.5 ± 1.3 mmHg, p >.05). GD-S had lower weight (p <.05) and worse CPET responses compared to C, including peak values of heart rate, oxygen consumption, carbondioxide production (VCO2), end-tidal pressure of CO2, and O2 pulse, as well as HR reserve after 3 min of recovery and the minute ventilation/VCO2 slope. Conclusions: Patients with GD type I have an abnormal CPET response compared to healthy controls likely due to the complex pathophysiologic process in GD that impacts multiple systems integral to the physiologic response to exercise.",
publisher = "John Wiley and Sons Inc",
journal = "Molecular Genetics and Genomic Medicine",
title = "Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I",
volume = "9",
number = "8",
doi = "10.1002/mgg3.1757"
}

Bjelobrk, M., Lakočević, M., Damjanović, S., Petakov, M., Petrović, M., Bosnić, Z., Arena, R.,& Popović, D.. (2021). Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I. in Molecular Genetics and Genomic Medicine
John Wiley and Sons Inc., 9(8).
https://doi.org/10.1002/mgg3.1757

Bjelobrk M, Lakočević M, Damjanović S, Petakov M, Petrović M, Bosnić Z, Arena R, Popović D. Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I. in Molecular Genetics and Genomic Medicine. 2021;9(8).
doi:10.1002/mgg3.1757 .

Bjelobrk, Marija, Lakočević, Milan, Damjanović, Svetozar, Petakov, Milan, Petrović, Milan, Bosnić, Zoran, Arena, Ross, Popović, Dejana, "Cardiopulmonary assessment of patients diagnosed with Gaucher’s disease type I" in Molecular Genetics and Genomic Medicine, 9, no. 8 (2021),
https://doi.org/10.1002/mgg3.1757 . .

TY  - JOUR
AU  - Culafić-Vojinović, Violeta
AU  - Ćulafić, Đorđe
AU  - Ignjatović, Svetlana
AU  - Petakov, Milan
AU  - Đurović-Nikolić, Marina
AU  - Vasić, Jelena
AU  - Mirković, Duško
AU  - Mijac, Dragana
AU  - Stulić, Miloš
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2146
AB  - Background: Metabolic bone disease in patients with chronic liver disease is called hepatic osteodystrophy and is primarily a sequel to osteopenia/osteoporosis, and rarely secondary to osteomalacia: The aim of this work was to define the influence of vitamin D-3 and parathyroid hormone (PTH) in the pathogenesis of hepatic osteodystrophy, as well as the predictive significance of biochemical bone markers. Methods: This prospective study included 58 male patients with alcoholic (49) and viral (9) cirrhosis. The concentrations of serum vitamin D-3, PTH, osteocalcin and beta-carboxy-terminal cross-linked telopeptide of type I collagen (beta-CTX) were determined. Bone density was measured by dual energy X-ray absorptiometry in the L1 -L4 spinal segment and the femoral neck. Results: Lower bone mineral density (BMD) was measured in 41 patients (70.7%). There was no significant correlation between PTH and vitamin D3 values and T score in the femoral neck (p=0.51; p=0.063) and lumbar spine (p=0.49; 0.064). Also, no significant correlation was found between the osteocalcin values in lumbar spine BMD (p=0.944) and femoral neck (p=0.161), or with beta-CTX values and BMD in the lumbar spine (p=0.347) and femoral neck (p=0.73). Statistically significant difference was confirmed between the stage A osteocalcin (p=0.000) and beta-CTX (p=0.008) values in relation to advanced stages B and C. Conclusions: PTH and vitamin D3 do not influence the development of hepatic osteodystrophy. In patients with cirrhosis, osteocalcin and beta-CTX are not valid indicators of decreased BMD, but their values correlate with the degree of liver insufficiency.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis
VL  - 33
IS  - 2
SP  - 149
EP  - 155
DO  - 10.2478/jomb-2013-0025
ER  - 

@article{
author = "Culafić-Vojinović, Violeta and Ćulafić, Đorđe and Ignjatović, Svetlana and Petakov, Milan and Đurović-Nikolić, Marina and Vasić, Jelena and Mirković, Duško and Mijac, Dragana and Stulić, Miloš",
year = "2014",
abstract = "Background: Metabolic bone disease in patients with chronic liver disease is called hepatic osteodystrophy and is primarily a sequel to osteopenia/osteoporosis, and rarely secondary to osteomalacia: The aim of this work was to define the influence of vitamin D-3 and parathyroid hormone (PTH) in the pathogenesis of hepatic osteodystrophy, as well as the predictive significance of biochemical bone markers. Methods: This prospective study included 58 male patients with alcoholic (49) and viral (9) cirrhosis. The concentrations of serum vitamin D-3, PTH, osteocalcin and beta-carboxy-terminal cross-linked telopeptide of type I collagen (beta-CTX) were determined. Bone density was measured by dual energy X-ray absorptiometry in the L1 -L4 spinal segment and the femoral neck. Results: Lower bone mineral density (BMD) was measured in 41 patients (70.7%). There was no significant correlation between PTH and vitamin D3 values and T score in the femoral neck (p=0.51; p=0.063) and lumbar spine (p=0.49; 0.064). Also, no significant correlation was found between the osteocalcin values in lumbar spine BMD (p=0.944) and femoral neck (p=0.161), or with beta-CTX values and BMD in the lumbar spine (p=0.347) and femoral neck (p=0.73). Statistically significant difference was confirmed between the stage A osteocalcin (p=0.000) and beta-CTX (p=0.008) values in relation to advanced stages B and C. Conclusions: PTH and vitamin D3 do not influence the development of hepatic osteodystrophy. In patients with cirrhosis, osteocalcin and beta-CTX are not valid indicators of decreased BMD, but their values correlate with the degree of liver insufficiency.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis",
volume = "33",
number = "2",
pages = "149-155",
doi = "10.2478/jomb-2013-0025"
}

Culafić-Vojinović, V., Ćulafić, Đ., Ignjatović, S., Petakov, M., Đurović-Nikolić, M., Vasić, J., Mirković, D., Mijac, D.,& Stulić, M.. (2014). The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 33(2), 149-155.
https://doi.org/10.2478/jomb-2013-0025

Culafić-Vojinović V, Ćulafić Đ, Ignjatović S, Petakov M, Đurović-Nikolić M, Vasić J, Mirković D, Mijac D, Stulić M. The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis. in Journal of Medical Biochemistry. 2014;33(2):149-155.
doi:10.2478/jomb-2013-0025 .

Culafić-Vojinović, Violeta, Ćulafić, Đorđe, Ignjatović, Svetlana, Petakov, Milan, Đurović-Nikolić, Marina, Vasić, Jelena, Mirković, Duško, Mijac, Dragana, Stulić, Miloš, "The clinical importance of biochemical bone markers in patients with alcoholic and viral liver cirrhosis" in Journal of Medical Biochemistry, 33, no. 2 (2014):149-155,
https://doi.org/10.2478/jomb-2013-0025 . .

TY  - JOUR
AU  - Šumarac, Zorica
AU  - Suvajdzić, Nada
AU  - Ignjatović, Svetlana
AU  - Majkić-Singh, Nada
AU  - Janić, Dragana
AU  - Petakov, Milan
AU  - Đorđević, Maja
AU  - Mitrović, Mirjana
AU  - Dajak, Marijana
AU  - Golubović, Milka
AU  - Rodić, Predrag
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1553
AB  - Objectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Clinical Biochemistry
T1  - Biomarkers in Serbian patients with Gaucher disease
VL  - 44
IS  - 12
SP  - 950
EP  - 954
DO  - 10.1016/j.clinbiochem.2011.05.016
ER  - 

@article{
author = "Šumarac, Zorica and Suvajdzić, Nada and Ignjatović, Svetlana and Majkić-Singh, Nada and Janić, Dragana and Petakov, Milan and Đorđević, Maja and Mitrović, Mirjana and Dajak, Marijana and Golubović, Milka and Rodić, Predrag",
year = "2011",
abstract = "Objectives: The aim of the study was to evaluate the efficiency of the biomarkers chitotriosidase (Chito), total acid phosphatase (TACP), angiotensin converting enzyme (ACE) and ferritin in the diagnosis of Gaucher disease (GD) and to assess the utility of biomarkers for monitoring the effects of enzyme replacement therapy (ERT). Design and methods: Forty treatment-naive Gaucher patients were studied. 27/40 GP were put on ERT and monitored every 6 months. Results: The baseline median values of Chito, TACP, ACE and ferritin were highly elevated in GP: 10216 nmol/mL/h, 26.1 U/L, 253 U/L, 515 mu g/L, and 555 mu g/L, respectively. The only significant difference between mild and moderate GP subgroups is observed for Chito activity (p=0.0116). During ERT, Chito showed the steepest decrease in regard to TACP and ACE, mainly within the first year (71.4%). Conclusions: Among these biomarkers, Chito proved to be the most useful biomarker for diagnosing GD and monitoring the ERT.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Clinical Biochemistry",
title = "Biomarkers in Serbian patients with Gaucher disease",
volume = "44",
number = "12",
pages = "950-954",
doi = "10.1016/j.clinbiochem.2011.05.016"
}

Šumarac, Z., Suvajdzić, N., Ignjatović, S., Majkić-Singh, N., Janić, D., Petakov, M., Đorđević, M., Mitrović, M., Dajak, M., Golubović, M.,& Rodić, P.. (2011). Biomarkers in Serbian patients with Gaucher disease. in Clinical Biochemistry
Pergamon-Elsevier Science Ltd, Oxford., 44(12), 950-954.
https://doi.org/10.1016/j.clinbiochem.2011.05.016

Šumarac Z, Suvajdzić N, Ignjatović S, Majkić-Singh N, Janić D, Petakov M, Đorđević M, Mitrović M, Dajak M, Golubović M, Rodić P. Biomarkers in Serbian patients with Gaucher disease. in Clinical Biochemistry. 2011;44(12):950-954.
doi:10.1016/j.clinbiochem.2011.05.016 .

Šumarac, Zorica, Suvajdzić, Nada, Ignjatović, Svetlana, Majkić-Singh, Nada, Janić, Dragana, Petakov, Milan, Đorđević, Maja, Mitrović, Mirjana, Dajak, Marijana, Golubović, Milka, Rodić, Predrag, "Biomarkers in Serbian patients with Gaucher disease" in Clinical Biochemistry, 44, no. 12 (2011):950-954,
https://doi.org/10.1016/j.clinbiochem.2011.05.016 . .