TY  - JOUR
AU  - Popović, Dejana
AU  - Damjanović, Svetozar
AU  - Popović, Bojana
AU  - Kocijančić, Aleksandar
AU  - Labudović, Dragana
AU  - Seman, Stefan
AU  - Stojiljković, Stanimir
AU  - Tesić, Milorad
AU  - Arena, Ross
AU  - Lasica, Ratko
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4020
AB  - Anticipation of stress induces physiological, behavioral and cognitive adjustments that are required for an appropriate response to the upcoming situation. Additional research examining the response of cardiopulmonary parameters and stress hormones during anticipation of stress in different chronic stress adaptive models is needed. As an addition to our previous research, a total of 57 subjects (16 elite male wrestlers, 21 water polo player and 20 sedentary subjects matched for age) were analyzed. Cardiopulmonary exercise testing (CPET) on a treadmill was used as the laboratory stress model; peak oxygen consumption (VO2) was obtained during CPET. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, alpha-melanocyte stimulating hormone (alpha-MSH) and N-terminal-pro-B type natriuretic peptide (NT-pro-BNP) were measured by radioimmunometric, radioimmunoassay and immunoassay sandwich technique, respectively, together with cardiopulmonary measurements, 10 minutes pre-CPET and at the initiation of CPET. The response of diastolic blood pressure and heart rate was different between groups during stress anticipation (p¼0.019, 0.049, respectively), while systolic blood pressure, peak VO2 and carbon-dioxide production responses were similar. ACTH and cortisol increased during the experimental condition, NT-pro-BNP decreased and alpha-MSH remained unchanged. All groups had similar hormonal responses during stress anticipation with the exception of the ACTH/cortisol ratio. In all three groups, DNT-pro-BNP during stress anticipation was the best independent predictor of peak VO2 (B¼36.01, r¼0.37, p¼0.001). In conclusion, the type of chronic stress exposure influences the hemodynamic response during anticipation of physical stress and the path of hormonal stress axis activation. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. LAY SUMMARY The study revealed differences in hormonal and hemodynamic responses during anticipation of stress between athletes and sedentary participants. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. Abbreviations: ACTH: adrenocorticitropic hormone; BSA: body surface area; BW: body weight; C: controls; CPET: cardiopulmonary exercise test; DBP: diastolic arterial blood pressure; FFM: fat-free mass; FM: fat mass; HR: heart rate; MSH: melanocyte-stimulating hormone; NT-pro-BNP: N terminal-pro-B type natriuretic peptide; SBP: systolic arterial blood pressure; VCO2: carbon dioxide production; VE: minute ventilation; VO2: oxygen consumption; W: wrestlers; WP: water polo players
PB  - Taylor and Francis Ltd.
T2  - Stress
T1  - Physiological behavior during stress anticipation across different chronic stress exposure adaptive models
DO  - 10.1080/10253890.2021.2006178
ER  - 

@article{
author = "Popović, Dejana and Damjanović, Svetozar and Popović, Bojana and Kocijančić, Aleksandar and Labudović, Dragana and Seman, Stefan and Stojiljković, Stanimir and Tesić, Milorad and Arena, Ross and Lasica, Ratko",
year = "2021",
abstract = "Anticipation of stress induces physiological, behavioral and cognitive adjustments that are required for an appropriate response to the upcoming situation. Additional research examining the response of cardiopulmonary parameters and stress hormones during anticipation of stress in different chronic stress adaptive models is needed. As an addition to our previous research, a total of 57 subjects (16 elite male wrestlers, 21 water polo player and 20 sedentary subjects matched for age) were analyzed. Cardiopulmonary exercise testing (CPET) on a treadmill was used as the laboratory stress model; peak oxygen consumption (VO2) was obtained during CPET. Plasma levels of adrenocorticotropic hormone (ACTH), cortisol, alpha-melanocyte stimulating hormone (alpha-MSH) and N-terminal-pro-B type natriuretic peptide (NT-pro-BNP) were measured by radioimmunometric, radioimmunoassay and immunoassay sandwich technique, respectively, together with cardiopulmonary measurements, 10 minutes pre-CPET and at the initiation of CPET. The response of diastolic blood pressure and heart rate was different between groups during stress anticipation (p¼0.019, 0.049, respectively), while systolic blood pressure, peak VO2 and carbon-dioxide production responses were similar. ACTH and cortisol increased during the experimental condition, NT-pro-BNP decreased and alpha-MSH remained unchanged. All groups had similar hormonal responses during stress anticipation with the exception of the ACTH/cortisol ratio. In all three groups, DNT-pro-BNP during stress anticipation was the best independent predictor of peak VO2 (B¼36.01, r¼0.37, p¼0.001). In conclusion, the type of chronic stress exposure influences the hemodynamic response during anticipation of physical stress and the path of hormonal stress axis activation. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. LAY SUMMARY The study revealed differences in hormonal and hemodynamic responses during anticipation of stress between athletes and sedentary participants. Stress hormones released during stress anticipation may hold predictive value for overall cardiopulmonary performance during the stress condition. Abbreviations: ACTH: adrenocorticitropic hormone; BSA: body surface area; BW: body weight; C: controls; CPET: cardiopulmonary exercise test; DBP: diastolic arterial blood pressure; FFM: fat-free mass; FM: fat mass; HR: heart rate; MSH: melanocyte-stimulating hormone; NT-pro-BNP: N terminal-pro-B type natriuretic peptide; SBP: systolic arterial blood pressure; VCO2: carbon dioxide production; VE: minute ventilation; VO2: oxygen consumption; W: wrestlers; WP: water polo players",
publisher = "Taylor and Francis Ltd.",
journal = "Stress",
title = "Physiological behavior during stress anticipation across different chronic stress exposure adaptive models",
doi = "10.1080/10253890.2021.2006178"
}

Popović, D., Damjanović, S., Popović, B., Kocijančić, A., Labudović, D., Seman, S., Stojiljković, S., Tesić, M., Arena, R.,& Lasica, R.. (2021). Physiological behavior during stress anticipation across different chronic stress exposure adaptive models. in Stress
Taylor and Francis Ltd...
https://doi.org/10.1080/10253890.2021.2006178

Popović D, Damjanović S, Popović B, Kocijančić A, Labudović D, Seman S, Stojiljković S, Tesić M, Arena R, Lasica R. Physiological behavior during stress anticipation across different chronic stress exposure adaptive models. in Stress. 2021;.
doi:10.1080/10253890.2021.2006178 .

Popović, Dejana, Damjanović, Svetozar, Popović, Bojana, Kocijančić, Aleksandar, Labudović, Dragana, Seman, Stefan, Stojiljković, Stanimir, Tesić, Milorad, Arena, Ross, Lasica, Ratko, "Physiological behavior during stress anticipation across different chronic stress exposure adaptive models" in Stress (2021),
https://doi.org/10.1080/10253890.2021.2006178 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Plećaš-Solarović, Bosiljka
AU  - Pešić, Vesna
AU  - Petrović, Milan
AU  - Vujisić-Tesić, Bosiljka
AU  - Popović, Bojana
AU  - Ignjatović, Svetlana
AU  - Ristić, Arsen
AU  - Damjanović, Svetozar S.
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2105
AB  - This aim of this study was to evaluate the predictive value of adrenocorticotropic hormone (ACTH), cortisol and ACTH receptor polymorphism (ACTHRP) for left ventricular (LV) remodeling. Thirty-six elite male athletes, as chronic stress adaptation models, and twenty sedentary age and sex-mached subjects emabarked on standard and tissue Doppler echocardiography to assess cardiac parameters at rest. They performed maximal cardiopulmonary test, which was used as an acute stress model. ACTH and cortisol were measured at rest (10 min before test), at beginning, at maximal effort, at 3rd min of recovery, using radioimmunometric and radioimmunoassey techniques, respectively. Promoter region of ACTHR gene (18p11.2) was analysed from blood samples using reverse polymerization reaction with the analysis of restriction fragment length polimorphisam by SacI restriction enzyme. Normal genotype was CTC/CTC, heterozygot for ACTHRP CTC/CCC and homozygot CCC/CCC. In all participants, ACTH and cortisol increased during acute stress, whereas in recovery ACTH increased and cortisol remained unchanged. 49/56 examiners manifested CTC/CTC, 7/56 CTC/CCC and 0/56 CCC/CCC. There was no difference in ACTHRP frequency between groups (chi(2)((1))= 0.178, p = 0.67). LV mass (LVM) and LV end-diastolic volume (LVVd) were higher in athletes than in controls (p  lt  0.01) and lower in CTC/CTC than in CTC/CCC genotype (219.43 +/- 46.59(SD)g vs. 276.34 +/- 48.86(SD)g, p = 0.004; 141.24 +/- 24.46(SD)ml vs. 175.29 +/- 37.07(SD)ml, p = 0.002; respectively). In all participants, predictors of LVM and LVVd were ACTH at rest (B = -1.00, -0.44; beta= -0.30, -0.31; p = 0.026,0.012, respectively) and ACTHRP (B = 56.63,34; beta= 0.37,0.40; p = 0.003,0.001, respectively). These results demonstrate that ACTH and ACTHRP strongly predict cardiac morphology suggesting possible regulatory role of stress system activity and sensitivity in cardiac remodeling.
PB  - Elsevier Science Inc, New York
T2  - Peptides
T1  - How does stress possibly affect cardiac remodeling?
VL  - 57
SP  - 20
EP  - 30
DO  - 10.1016/j.peptides.2014.04.006
ER  - 

@article{
author = "Popović, Dejana and Plećaš-Solarović, Bosiljka and Pešić, Vesna and Petrović, Milan and Vujisić-Tesić, Bosiljka and Popović, Bojana and Ignjatović, Svetlana and Ristić, Arsen and Damjanović, Svetozar S.",
year = "2014",
abstract = "This aim of this study was to evaluate the predictive value of adrenocorticotropic hormone (ACTH), cortisol and ACTH receptor polymorphism (ACTHRP) for left ventricular (LV) remodeling. Thirty-six elite male athletes, as chronic stress adaptation models, and twenty sedentary age and sex-mached subjects emabarked on standard and tissue Doppler echocardiography to assess cardiac parameters at rest. They performed maximal cardiopulmonary test, which was used as an acute stress model. ACTH and cortisol were measured at rest (10 min before test), at beginning, at maximal effort, at 3rd min of recovery, using radioimmunometric and radioimmunoassey techniques, respectively. Promoter region of ACTHR gene (18p11.2) was analysed from blood samples using reverse polymerization reaction with the analysis of restriction fragment length polimorphisam by SacI restriction enzyme. Normal genotype was CTC/CTC, heterozygot for ACTHRP CTC/CCC and homozygot CCC/CCC. In all participants, ACTH and cortisol increased during acute stress, whereas in recovery ACTH increased and cortisol remained unchanged. 49/56 examiners manifested CTC/CTC, 7/56 CTC/CCC and 0/56 CCC/CCC. There was no difference in ACTHRP frequency between groups (chi(2)((1))= 0.178, p = 0.67). LV mass (LVM) and LV end-diastolic volume (LVVd) were higher in athletes than in controls (p  lt  0.01) and lower in CTC/CTC than in CTC/CCC genotype (219.43 +/- 46.59(SD)g vs. 276.34 +/- 48.86(SD)g, p = 0.004; 141.24 +/- 24.46(SD)ml vs. 175.29 +/- 37.07(SD)ml, p = 0.002; respectively). In all participants, predictors of LVM and LVVd were ACTH at rest (B = -1.00, -0.44; beta= -0.30, -0.31; p = 0.026,0.012, respectively) and ACTHRP (B = 56.63,34; beta= 0.37,0.40; p = 0.003,0.001, respectively). These results demonstrate that ACTH and ACTHRP strongly predict cardiac morphology suggesting possible regulatory role of stress system activity and sensitivity in cardiac remodeling.",
publisher = "Elsevier Science Inc, New York",
journal = "Peptides",
title = "How does stress possibly affect cardiac remodeling?",
volume = "57",
pages = "20-30",
doi = "10.1016/j.peptides.2014.04.006"
}

Popović, D., Plećaš-Solarović, B., Pešić, V., Petrović, M., Vujisić-Tesić, B., Popović, B., Ignjatović, S., Ristić, A.,& Damjanović, S. S.. (2014). How does stress possibly affect cardiac remodeling?. in Peptides
Elsevier Science Inc, New York., 57, 20-30.
https://doi.org/10.1016/j.peptides.2014.04.006

Popović D, Plećaš-Solarović B, Pešić V, Petrović M, Vujisić-Tesić B, Popović B, Ignjatović S, Ristić A, Damjanović SS. How does stress possibly affect cardiac remodeling?. in Peptides. 2014;57:20-30.
doi:10.1016/j.peptides.2014.04.006 .

Popović, Dejana, Plećaš-Solarović, Bosiljka, Pešić, Vesna, Petrović, Milan, Vujisić-Tesić, Bosiljka, Popović, Bojana, Ignjatović, Svetlana, Ristić, Arsen, Damjanović, Svetozar S., "How does stress possibly affect cardiac remodeling?" in Peptides, 57 (2014):20-30,
https://doi.org/10.1016/j.peptides.2014.04.006 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Popović, Bojana
AU  - Plećaš-Solarović, Bosiljka
AU  - Pešić, Vesna
AU  - Marković, Vidan
AU  - Stojiljković, Stanimir
AU  - Vukcević, Vladan
AU  - Petrović, Ivana
AU  - Banović, Marko
AU  - Petrović, Milan
AU  - Vujisić-Tesić, Bosiljka
AU  - Ostojić, Miodrag
AU  - Ristić, Arsen
AU  - Damjanović, Svetozar S.
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1857
AB  - Brain natriuretic peptide (NT-pro-BNP) was implicated in the regulation of hypothalamic-pituitary-adrenocortical (HPA) responses to psychological stressors. However, HPA axis activation in different physical stress models and its interface with NT-pro-BNP in the prediction of cardiopulmonary performance is unclear. Cardiopulmonary test on a treadmill was used to assess cardiopulmonary parameters in 16 elite male wrestlers (W), 21 water polo player (WP) and 20 sedentary age-matched subjects
PB  - Elsevier Science Inc, New York
T2  - Peptides
T1  - The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress
VL  - 47
SP  - 85
EP  - 93
DO  - 10.1016/j.peptides.2013.07.009
ER  - 

@article{
author = "Popović, Dejana and Popović, Bojana and Plećaš-Solarović, Bosiljka and Pešić, Vesna and Marković, Vidan and Stojiljković, Stanimir and Vukcević, Vladan and Petrović, Ivana and Banović, Marko and Petrović, Milan and Vujisić-Tesić, Bosiljka and Ostojić, Miodrag and Ristić, Arsen and Damjanović, Svetozar S.",
year = "2013",
abstract = "Brain natriuretic peptide (NT-pro-BNP) was implicated in the regulation of hypothalamic-pituitary-adrenocortical (HPA) responses to psychological stressors. However, HPA axis activation in different physical stress models and its interface with NT-pro-BNP in the prediction of cardiopulmonary performance is unclear. Cardiopulmonary test on a treadmill was used to assess cardiopulmonary parameters in 16 elite male wrestlers (W), 21 water polo player (WP) and 20 sedentary age-matched subjects",
publisher = "Elsevier Science Inc, New York",
journal = "Peptides",
title = "The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress",
volume = "47",
pages = "85-93",
doi = "10.1016/j.peptides.2013.07.009"
}

Popović, D., Popović, B., Plećaš-Solarović, B., Pešić, V., Marković, V., Stojiljković, S., Vukcević, V., Petrović, I., Banović, M., Petrović, M., Vujisić-Tesić, B., Ostojić, M., Ristić, A.,& Damjanović, S. S.. (2013). The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress. in Peptides
Elsevier Science Inc, New York., 47, 85-93.
https://doi.org/10.1016/j.peptides.2013.07.009

Popović D, Popović B, Plećaš-Solarović B, Pešić V, Marković V, Stojiljković S, Vukcević V, Petrović I, Banović M, Petrović M, Vujisić-Tesić B, Ostojić M, Ristić A, Damjanović SS. The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress. in Peptides. 2013;47:85-93.
doi:10.1016/j.peptides.2013.07.009 .

Popović, Dejana, Popović, Bojana, Plećaš-Solarović, Bosiljka, Pešić, Vesna, Marković, Vidan, Stojiljković, Stanimir, Vukcević, Vladan, Petrović, Ivana, Banović, Marko, Petrović, Milan, Vujisić-Tesić, Bosiljka, Ostojić, Miodrag, Ristić, Arsen, Damjanović, Svetozar S., "The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress" in Peptides, 47 (2013):85-93,
https://doi.org/10.1016/j.peptides.2013.07.009 . .