TY  - JOUR
AU  - Petrović, Milan
AU  - Petrović, Marija
AU  - Milasinović, Goran
AU  - Vujisić-Tesić, Bosiljka
AU  - Trifunović, Danijela
AU  - Petrović, Olga
AU  - Nedeljković, Ivana
AU  - Petrović, Ivana
AU  - Banović, Marko
AU  - Boricić-Kostić, Marija
AU  - Petrović, Jelena
AU  - Arena, Ross
AU  - Popović, Dejana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2918
AB  - Aims: Selection of patients who are viable candidates for cardiac resynchronization therapy (CRT), prediction of the response to CRT as well as an optimal definition of a favorable response, all require further exploration. The purpose of this study was to evaluate the interplay between the prediction of the response to CRT and the definition of a favorable outcome. Methods: Seventy patients who received CRT were included. All patients met current guideline criteria for CRT. Forty-three echocardiographic parameters were evaluated before CRT and at 1, 3, 6, and 12 months. M-mode, 2D echocardiography, and Doppler imaging were used to quantify left ventricular (LV) systolic and diastolic function, mitral regurgitation, right ventricular systolic function, pulmonary artery pressure, and myocardial mechanical dyssynchrony. The following definitions of a favorable CRT response were used: left ventricular ejection fraction (LVEF) improvement more >5% acutely following CRT, LVEF improvement >20% at 12-month follow-up, and a LV end-systolic volume (LVESV) decrease >15% at 12-month follow-up. Results: For the LVEF improvement >5%, the best predictor was isovolumetric relaxation time (IVRT; P=.035). For improvement of LVEF >20%, the best predictors were left ventricular stroke index (LVSI; P=.044) and left ventricular fractional shortening (LVFS; P=.031). For the drop in left ventricular systolic volume (LVESV >15%), the best predictor was septal-to-lateral wall delay (Delta T) (P=.043, RR=1.023, 95% CI for RR=1.001-1.045). Conclusion: The definition of a favorable CRT response influenced the optimal predictor variable(s). Standardization of defining a favorable response to CRT is needed to guide clinical decision making processes.
PB  - Wiley, Hoboken
T2  - Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
T1  - Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome
VL  - 34
IS  - 3
SP  - 371
EP  - 375
DO  - 10.1111/echo.13453
ER  - 

@article{
author = "Petrović, Milan and Petrović, Marija and Milasinović, Goran and Vujisić-Tesić, Bosiljka and Trifunović, Danijela and Petrović, Olga and Nedeljković, Ivana and Petrović, Ivana and Banović, Marko and Boricić-Kostić, Marija and Petrović, Jelena and Arena, Ross and Popović, Dejana",
year = "2017",
abstract = "Aims: Selection of patients who are viable candidates for cardiac resynchronization therapy (CRT), prediction of the response to CRT as well as an optimal definition of a favorable response, all require further exploration. The purpose of this study was to evaluate the interplay between the prediction of the response to CRT and the definition of a favorable outcome. Methods: Seventy patients who received CRT were included. All patients met current guideline criteria for CRT. Forty-three echocardiographic parameters were evaluated before CRT and at 1, 3, 6, and 12 months. M-mode, 2D echocardiography, and Doppler imaging were used to quantify left ventricular (LV) systolic and diastolic function, mitral regurgitation, right ventricular systolic function, pulmonary artery pressure, and myocardial mechanical dyssynchrony. The following definitions of a favorable CRT response were used: left ventricular ejection fraction (LVEF) improvement more >5% acutely following CRT, LVEF improvement >20% at 12-month follow-up, and a LV end-systolic volume (LVESV) decrease >15% at 12-month follow-up. Results: For the LVEF improvement >5%, the best predictor was isovolumetric relaxation time (IVRT; P=.035). For improvement of LVEF >20%, the best predictors were left ventricular stroke index (LVSI; P=.044) and left ventricular fractional shortening (LVFS; P=.031). For the drop in left ventricular systolic volume (LVESV >15%), the best predictor was septal-to-lateral wall delay (Delta T) (P=.043, RR=1.023, 95% CI for RR=1.001-1.045). Conclusion: The definition of a favorable CRT response influenced the optimal predictor variable(s). Standardization of defining a favorable response to CRT is needed to guide clinical decision making processes.",
publisher = "Wiley, Hoboken",
journal = "Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques",
title = "Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome",
volume = "34",
number = "3",
pages = "371-375",
doi = "10.1111/echo.13453"
}

Petrović, M., Petrović, M., Milasinović, G., Vujisić-Tesić, B., Trifunović, D., Petrović, O., Nedeljković, I., Petrović, I., Banović, M., Boricić-Kostić, M., Petrović, J., Arena, R.,& Popović, D.. (2017). Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome. in Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques
Wiley, Hoboken., 34(3), 371-375.
https://doi.org/10.1111/echo.13453

Petrović M, Petrović M, Milasinović G, Vujisić-Tesić B, Trifunović D, Petrović O, Nedeljković I, Petrović I, Banović M, Boricić-Kostić M, Petrović J, Arena R, Popović D. Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome. in Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques. 2017;34(3):371-375.
doi:10.1111/echo.13453 .

Petrović, Milan, Petrović, Marija, Milasinović, Goran, Vujisić-Tesić, Bosiljka, Trifunović, Danijela, Petrović, Olga, Nedeljković, Ivana, Petrović, Ivana, Banović, Marko, Boricić-Kostić, Marija, Petrović, Jelena, Arena, Ross, Popović, Dejana, "Gauging the response to cardiac resynchronization therapy: The important interplay between predictor variables and definition of a favorable outcome" in Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques, 34, no. 3 (2017):371-375,
https://doi.org/10.1111/echo.13453 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Plećaš-Solarović, Bosiljka
AU  - Pešić, Vesna
AU  - Petrović, Milan
AU  - Vujisić-Tesić, Bosiljka
AU  - Popović, Bojana
AU  - Ignjatović, Svetlana
AU  - Ristić, Arsen
AU  - Damjanović, Svetozar S.
PY  - 2014
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2105
AB  - This aim of this study was to evaluate the predictive value of adrenocorticotropic hormone (ACTH), cortisol and ACTH receptor polymorphism (ACTHRP) for left ventricular (LV) remodeling. Thirty-six elite male athletes, as chronic stress adaptation models, and twenty sedentary age and sex-mached subjects emabarked on standard and tissue Doppler echocardiography to assess cardiac parameters at rest. They performed maximal cardiopulmonary test, which was used as an acute stress model. ACTH and cortisol were measured at rest (10 min before test), at beginning, at maximal effort, at 3rd min of recovery, using radioimmunometric and radioimmunoassey techniques, respectively. Promoter region of ACTHR gene (18p11.2) was analysed from blood samples using reverse polymerization reaction with the analysis of restriction fragment length polimorphisam by SacI restriction enzyme. Normal genotype was CTC/CTC, heterozygot for ACTHRP CTC/CCC and homozygot CCC/CCC. In all participants, ACTH and cortisol increased during acute stress, whereas in recovery ACTH increased and cortisol remained unchanged. 49/56 examiners manifested CTC/CTC, 7/56 CTC/CCC and 0/56 CCC/CCC. There was no difference in ACTHRP frequency between groups (chi(2)((1))= 0.178, p = 0.67). LV mass (LVM) and LV end-diastolic volume (LVVd) were higher in athletes than in controls (p  lt  0.01) and lower in CTC/CTC than in CTC/CCC genotype (219.43 +/- 46.59(SD)g vs. 276.34 +/- 48.86(SD)g, p = 0.004; 141.24 +/- 24.46(SD)ml vs. 175.29 +/- 37.07(SD)ml, p = 0.002; respectively). In all participants, predictors of LVM and LVVd were ACTH at rest (B = -1.00, -0.44; beta= -0.30, -0.31; p = 0.026,0.012, respectively) and ACTHRP (B = 56.63,34; beta= 0.37,0.40; p = 0.003,0.001, respectively). These results demonstrate that ACTH and ACTHRP strongly predict cardiac morphology suggesting possible regulatory role of stress system activity and sensitivity in cardiac remodeling.
PB  - Elsevier Science Inc, New York
T2  - Peptides
T1  - How does stress possibly affect cardiac remodeling?
VL  - 57
SP  - 20
EP  - 30
DO  - 10.1016/j.peptides.2014.04.006
ER  - 

@article{
author = "Popović, Dejana and Plećaš-Solarović, Bosiljka and Pešić, Vesna and Petrović, Milan and Vujisić-Tesić, Bosiljka and Popović, Bojana and Ignjatović, Svetlana and Ristić, Arsen and Damjanović, Svetozar S.",
year = "2014",
abstract = "This aim of this study was to evaluate the predictive value of adrenocorticotropic hormone (ACTH), cortisol and ACTH receptor polymorphism (ACTHRP) for left ventricular (LV) remodeling. Thirty-six elite male athletes, as chronic stress adaptation models, and twenty sedentary age and sex-mached subjects emabarked on standard and tissue Doppler echocardiography to assess cardiac parameters at rest. They performed maximal cardiopulmonary test, which was used as an acute stress model. ACTH and cortisol were measured at rest (10 min before test), at beginning, at maximal effort, at 3rd min of recovery, using radioimmunometric and radioimmunoassey techniques, respectively. Promoter region of ACTHR gene (18p11.2) was analysed from blood samples using reverse polymerization reaction with the analysis of restriction fragment length polimorphisam by SacI restriction enzyme. Normal genotype was CTC/CTC, heterozygot for ACTHRP CTC/CCC and homozygot CCC/CCC. In all participants, ACTH and cortisol increased during acute stress, whereas in recovery ACTH increased and cortisol remained unchanged. 49/56 examiners manifested CTC/CTC, 7/56 CTC/CCC and 0/56 CCC/CCC. There was no difference in ACTHRP frequency between groups (chi(2)((1))= 0.178, p = 0.67). LV mass (LVM) and LV end-diastolic volume (LVVd) were higher in athletes than in controls (p  lt  0.01) and lower in CTC/CTC than in CTC/CCC genotype (219.43 +/- 46.59(SD)g vs. 276.34 +/- 48.86(SD)g, p = 0.004; 141.24 +/- 24.46(SD)ml vs. 175.29 +/- 37.07(SD)ml, p = 0.002; respectively). In all participants, predictors of LVM and LVVd were ACTH at rest (B = -1.00, -0.44; beta= -0.30, -0.31; p = 0.026,0.012, respectively) and ACTHRP (B = 56.63,34; beta= 0.37,0.40; p = 0.003,0.001, respectively). These results demonstrate that ACTH and ACTHRP strongly predict cardiac morphology suggesting possible regulatory role of stress system activity and sensitivity in cardiac remodeling.",
publisher = "Elsevier Science Inc, New York",
journal = "Peptides",
title = "How does stress possibly affect cardiac remodeling?",
volume = "57",
pages = "20-30",
doi = "10.1016/j.peptides.2014.04.006"
}

Popović, D., Plećaš-Solarović, B., Pešić, V., Petrović, M., Vujisić-Tesić, B., Popović, B., Ignjatović, S., Ristić, A.,& Damjanović, S. S.. (2014). How does stress possibly affect cardiac remodeling?. in Peptides
Elsevier Science Inc, New York., 57, 20-30.
https://doi.org/10.1016/j.peptides.2014.04.006

Popović D, Plećaš-Solarović B, Pešić V, Petrović M, Vujisić-Tesić B, Popović B, Ignjatović S, Ristić A, Damjanović SS. How does stress possibly affect cardiac remodeling?. in Peptides. 2014;57:20-30.
doi:10.1016/j.peptides.2014.04.006 .

Popović, Dejana, Plećaš-Solarović, Bosiljka, Pešić, Vesna, Petrović, Milan, Vujisić-Tesić, Bosiljka, Popović, Bojana, Ignjatović, Svetlana, Ristić, Arsen, Damjanović, Svetozar S., "How does stress possibly affect cardiac remodeling?" in Peptides, 57 (2014):20-30,
https://doi.org/10.1016/j.peptides.2014.04.006 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Popović, Bojana
AU  - Plećaš-Solarović, Bosiljka
AU  - Pešić, Vesna
AU  - Marković, Vidan
AU  - Stojiljković, Stanimir
AU  - Vukcević, Vladan
AU  - Petrović, Ivana
AU  - Banović, Marko
AU  - Petrović, Milan
AU  - Vujisić-Tesić, Bosiljka
AU  - Ostojić, Miodrag
AU  - Ristić, Arsen
AU  - Damjanović, Svetozar S.
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1857
AB  - Brain natriuretic peptide (NT-pro-BNP) was implicated in the regulation of hypothalamic-pituitary-adrenocortical (HPA) responses to psychological stressors. However, HPA axis activation in different physical stress models and its interface with NT-pro-BNP in the prediction of cardiopulmonary performance is unclear. Cardiopulmonary test on a treadmill was used to assess cardiopulmonary parameters in 16 elite male wrestlers (W), 21 water polo player (WP) and 20 sedentary age-matched subjects
PB  - Elsevier Science Inc, New York
T2  - Peptides
T1  - The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress
VL  - 47
SP  - 85
EP  - 93
DO  - 10.1016/j.peptides.2013.07.009
ER  - 

@article{
author = "Popović, Dejana and Popović, Bojana and Plećaš-Solarović, Bosiljka and Pešić, Vesna and Marković, Vidan and Stojiljković, Stanimir and Vukcević, Vladan and Petrović, Ivana and Banović, Marko and Petrović, Milan and Vujisić-Tesić, Bosiljka and Ostojić, Miodrag and Ristić, Arsen and Damjanović, Svetozar S.",
year = "2013",
abstract = "Brain natriuretic peptide (NT-pro-BNP) was implicated in the regulation of hypothalamic-pituitary-adrenocortical (HPA) responses to psychological stressors. However, HPA axis activation in different physical stress models and its interface with NT-pro-BNP in the prediction of cardiopulmonary performance is unclear. Cardiopulmonary test on a treadmill was used to assess cardiopulmonary parameters in 16 elite male wrestlers (W), 21 water polo player (WP) and 20 sedentary age-matched subjects",
publisher = "Elsevier Science Inc, New York",
journal = "Peptides",
title = "The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress",
volume = "47",
pages = "85-93",
doi = "10.1016/j.peptides.2013.07.009"
}

Popović, D., Popović, B., Plećaš-Solarović, B., Pešić, V., Marković, V., Stojiljković, S., Vukcević, V., Petrović, I., Banović, M., Petrović, M., Vujisić-Tesić, B., Ostojić, M., Ristić, A.,& Damjanović, S. S.. (2013). The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress. in Peptides
Elsevier Science Inc, New York., 47, 85-93.
https://doi.org/10.1016/j.peptides.2013.07.009

Popović D, Popović B, Plećaš-Solarović B, Pešić V, Marković V, Stojiljković S, Vukcević V, Petrović I, Banović M, Petrović M, Vujisić-Tesić B, Ostojić M, Ristić A, Damjanović SS. The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress. in Peptides. 2013;47:85-93.
doi:10.1016/j.peptides.2013.07.009 .

Popović, Dejana, Popović, Bojana, Plećaš-Solarović, Bosiljka, Pešić, Vesna, Marković, Vidan, Stojiljković, Stanimir, Vukcević, Vladan, Petrović, Ivana, Banović, Marko, Petrović, Milan, Vujisić-Tesić, Bosiljka, Ostojić, Miodrag, Ristić, Arsen, Damjanović, Svetozar S., "The interface of hypothalamic-pituitary-adrenocortical axis and circulating brain natriuretic peptide in prediction of cardiopulmonary performance during physical stress" in Peptides, 47 (2013):85-93,
https://doi.org/10.1016/j.peptides.2013.07.009 . .