TY  - JOUR
AU  - Popović, Dejana
AU  - Guazzi, Marco
AU  - Jakovljević, Đorđe G.
AU  - Lasica, Ratko
AU  - Banović, Marko
AU  - Ostojić, Miodrag
AU  - Arena, Ross
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3316
AB  - Background: This study examined the accuracy of cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometry (RE) in the predicting coronary artery disease (CAD) severity and prognosis. Methods: Forty Caucasian subjects, mean age 63.5 +/- 7.6, with significant coronary artery lesions (>= 50%) were included. Within two months of coronary angiography, TM and RE CPET were performed on two visits 2-4 days apart and subsequently followed up to 32 +/- 10 months. Results: Mean left ventricular ejection fraction was 56.7 +/- 9.6%. TM CPET exhibited a higher occurrence of ST segment depression >= 1 mm (71.05% vs 28.95%, p = 0.04). Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a better CPET response compared to those with 3-SCA. ROC analysis revealed a high predictive value for the ventilation/carbon dioxide production (VE/VCO2) slope obtained on TM (area 0.84, p = 0.003, Sn 88.9%, Sp 72%) in distinguishing between 1 and 2-SCA and 3-SCA. Among all CPET parameters, work efficiency (Delta VO2/Delta WR) during RE predicted cumulative cardiac events (p  lt  0.01). Conclusions: CPET parameters hold predictive value for CAD severity and prognosis. CPET on a TM appears to be more reliable in the quantification of CAD compared to RE.
PB  - Elsevier Ireland Ltd, Clare
T2  - International Journal of Cardiology
T1  - Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing
VL  - 285
SP  - 11
EP  - 13
DO  - 10.1016/j.ijcard.2019.03.012
ER  - 

@article{
author = "Popović, Dejana and Guazzi, Marco and Jakovljević, Đorđe G. and Lasica, Ratko and Banović, Marko and Ostojić, Miodrag and Arena, Ross",
year = "2019",
abstract = "Background: This study examined the accuracy of cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometry (RE) in the predicting coronary artery disease (CAD) severity and prognosis. Methods: Forty Caucasian subjects, mean age 63.5 +/- 7.6, with significant coronary artery lesions (>= 50%) were included. Within two months of coronary angiography, TM and RE CPET were performed on two visits 2-4 days apart and subsequently followed up to 32 +/- 10 months. Results: Mean left ventricular ejection fraction was 56.7 +/- 9.6%. TM CPET exhibited a higher occurrence of ST segment depression >= 1 mm (71.05% vs 28.95%, p = 0.04). Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a better CPET response compared to those with 3-SCA. ROC analysis revealed a high predictive value for the ventilation/carbon dioxide production (VE/VCO2) slope obtained on TM (area 0.84, p = 0.003, Sn 88.9%, Sp 72%) in distinguishing between 1 and 2-SCA and 3-SCA. Among all CPET parameters, work efficiency (Delta VO2/Delta WR) during RE predicted cumulative cardiac events (p  lt  0.01). Conclusions: CPET parameters hold predictive value for CAD severity and prognosis. CPET on a TM appears to be more reliable in the quantification of CAD compared to RE.",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "International Journal of Cardiology",
title = "Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing",
volume = "285",
pages = "11-13",
doi = "10.1016/j.ijcard.2019.03.012"
}

Popović, D., Guazzi, M., Jakovljević, Đ. G., Lasica, R., Banović, M., Ostojić, M.,& Arena, R.. (2019). Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing. in International Journal of Cardiology
Elsevier Ireland Ltd, Clare., 285, 11-13.
https://doi.org/10.1016/j.ijcard.2019.03.012

Popović D, Guazzi M, Jakovljević ĐG, Lasica R, Banović M, Ostojić M, Arena R. Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing. in International Journal of Cardiology. 2019;285:11-13.
doi:10.1016/j.ijcard.2019.03.012 .

Popović, Dejana, Guazzi, Marco, Jakovljević, Đorđe G., Lasica, Ratko, Banović, Marko, Ostojić, Miodrag, Arena, Ross, "Quantification of coronary artery disease using different modalities of cardiopulmonary exercise testing" in International Journal of Cardiology, 285 (2019):11-13,
https://doi.org/10.1016/j.ijcard.2019.03.012 . .

TY  - JOUR
AU  - Popović, Dejana
AU  - Damjanović, Svetozar S.
AU  - Đorđević, Tea
AU  - Martić, Dejana
AU  - Ignjatović, Svetlana
AU  - Milinković, Neda
AU  - Banović, Marko
AU  - Lasica, Ratko
AU  - Petrović, Milan
AU  - Guazzi, Marco
AU  - Arena, Ross
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2861
AB  - Objectives: Despite considerable knowledge regarding the importance of stress in coronary artery disease (CAD) pathogenesis, its underestimation persists in routine clinical practice, in part attributable to lack of a standardized, objective assessment. The current study examined the ability of stress hormones to predict CAD severity and prognosis at basal conditions as well as during and following an exertional stimulus.Materials and methods: Forty Caucasian subjects with significant coronary artery lesions (50%) were included. Within 2 months of coronary angiography, cardiopulmonary exercise testing (CPET) on a recumbent ergometer was performed in conjunction with stress echocardiography (SE). At rest, peak and after 3min of recovery following CPET, plasma levels of cortisol, adrenocorticotropic hormone (ACTH) and NT-pro-brain natriuretic peptide (NT-pro-BNP) were measured by immunoassay sandwich technique, radioimmunoassay, and radioimmunometric technique, respectively. Subjects were subsequently followed a mean of 3210months.Results and discussion: Mean ejection fraction was 56.7 +/- 9.6%. Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a significantly lower plasma cortisol levels during CPET compared to those with 3-SCA (p lt .05), whereas ACTH and NT-pro-BNP were not significantly different (p>.05). Among CPET, SE, and hormonal parameters, cortisol at rest and during CPET recovery demonstrated the best predictive value in distinguishing between 1-, 2-, and 3-SCA [area under ROC curve 0.75 and 0.77 (SE=0.11, 0.10; p=.043, .04) for rest and recovery, respectively]. Cortisol peak/rest predicted cumulative cardiac events (area under ROC curve 0.75, SE=0.10, p=.049).Conclusions: Cortisol at rest and following an exercise test holds predictive value for CAD severity and prognosis, further demonstrating a link between stress and unwanted cardiac events.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Supportive Care in Cancer
T1  - Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome
VL  - 20
IS  - 5
SP  - 523
EP  - 531
DO  - 10.1080/10253890.2017.1368488
ER  - 

@article{
author = "Popović, Dejana and Damjanović, Svetozar S. and Đorđević, Tea and Martić, Dejana and Ignjatović, Svetlana and Milinković, Neda and Banović, Marko and Lasica, Ratko and Petrović, Milan and Guazzi, Marco and Arena, Ross",
year = "2017",
abstract = "Objectives: Despite considerable knowledge regarding the importance of stress in coronary artery disease (CAD) pathogenesis, its underestimation persists in routine clinical practice, in part attributable to lack of a standardized, objective assessment. The current study examined the ability of stress hormones to predict CAD severity and prognosis at basal conditions as well as during and following an exertional stimulus.Materials and methods: Forty Caucasian subjects with significant coronary artery lesions (50%) were included. Within 2 months of coronary angiography, cardiopulmonary exercise testing (CPET) on a recumbent ergometer was performed in conjunction with stress echocardiography (SE). At rest, peak and after 3min of recovery following CPET, plasma levels of cortisol, adrenocorticotropic hormone (ACTH) and NT-pro-brain natriuretic peptide (NT-pro-BNP) were measured by immunoassay sandwich technique, radioimmunoassay, and radioimmunometric technique, respectively. Subjects were subsequently followed a mean of 3210months.Results and discussion: Mean ejection fraction was 56.7 +/- 9.6%. Subjects with 1-2 stenotic coronary arteries (SCA) demonstrated a significantly lower plasma cortisol levels during CPET compared to those with 3-SCA (p lt .05), whereas ACTH and NT-pro-BNP were not significantly different (p>.05). Among CPET, SE, and hormonal parameters, cortisol at rest and during CPET recovery demonstrated the best predictive value in distinguishing between 1-, 2-, and 3-SCA [area under ROC curve 0.75 and 0.77 (SE=0.11, 0.10; p=.043, .04) for rest and recovery, respectively]. Cortisol peak/rest predicted cumulative cardiac events (area under ROC curve 0.75, SE=0.10, p=.049).Conclusions: Cortisol at rest and following an exercise test holds predictive value for CAD severity and prognosis, further demonstrating a link between stress and unwanted cardiac events.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Supportive Care in Cancer",
title = "Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome",
volume = "20",
number = "5",
pages = "523-531",
doi = "10.1080/10253890.2017.1368488"
}

Popović, D., Damjanović, S. S., Đorđević, T., Martić, D., Ignjatović, S., Milinković, N., Banović, M., Lasica, R., Petrović, M., Guazzi, M.,& Arena, R.. (2017). Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome. in Supportive Care in Cancer
Taylor & Francis Ltd, Abingdon., 20(5), 523-531.
https://doi.org/10.1080/10253890.2017.1368488

Popović D, Damjanović SS, Đorđević T, Martić D, Ignjatović S, Milinković N, Banović M, Lasica R, Petrović M, Guazzi M, Arena R. Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome. in Supportive Care in Cancer. 2017;20(5):523-531.
doi:10.1080/10253890.2017.1368488 .

Popović, Dejana, Damjanović, Svetozar S., Đorđević, Tea, Martić, Dejana, Ignjatović, Svetlana, Milinković, Neda, Banović, Marko, Lasica, Ratko, Petrović, Milan, Guazzi, Marco, Arena, Ross, "Stress hormones at rest and following exercise testing predict coronary artery disease severity and outcome" in Supportive Care in Cancer, 20, no. 5 (2017):523-531,
https://doi.org/10.1080/10253890.2017.1368488 . .