TY  - JOUR
AU  - Lukić, Milica
AU  - Jaksić, I.
AU  - Krstonosić, Veljko
AU  - Cekić, Nebojša
AU  - Savić, Snežana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1709
AB  - To formulate a consumer-acceptable cosmetic product, numerous demands have to be fulfilled, and as the most important, efficacy (both real and perceived), adequate aesthetic (visual perception) and all sensorial characteristics have to be achieved. In this study, four model water-in-oil creams intended for hand care, varying in one emollient component, were submitted to rheological, sensory and textural characterization, and their efficacy was evaluated in in vivo study on human volunteers. Our results indicate that certain alteration restricted to the oil phase induced a change in all investigated characteristics, showing that each instrumental measurement can be used as a sensitive tool in the characterization of cream samples. Regarding the correlation between physical measurements and certain sensory attributes, it is possible to formulate a product with specific sensory characteristics by using pre-defined rheological or textural parameters. To obtain a complete sensory profile of a cosmetic product, a detailed sensory evaluation should be carried out according to the existing standard practices, which are both time- and money-consuming. However, a modified sensory study could be useful for fast in-line screening along with instrumental characterization of a novel cosmetic emulsion product and could be particularly helpful in the process of distinguishing a single formulation from several differing in one component.
PB  - Wiley-Blackwell, Hoboken
T2  - International Journal of Cosmetic Science
T1  - A combined approach in characterization of an effective w/o hand cream: the influence of emollient on textural, sensorial and in vivo skin performance
VL  - 34
IS  - 2
SP  - 140
EP  - 149
DO  - 10.1111/j.1468-2494.2011.00693.x
ER  - 

@article{
author = "Lukić, Milica and Jaksić, I. and Krstonosić, Veljko and Cekić, Nebojša and Savić, Snežana",
year = "2012",
abstract = "To formulate a consumer-acceptable cosmetic product, numerous demands have to be fulfilled, and as the most important, efficacy (both real and perceived), adequate aesthetic (visual perception) and all sensorial characteristics have to be achieved. In this study, four model water-in-oil creams intended for hand care, varying in one emollient component, were submitted to rheological, sensory and textural characterization, and their efficacy was evaluated in in vivo study on human volunteers. Our results indicate that certain alteration restricted to the oil phase induced a change in all investigated characteristics, showing that each instrumental measurement can be used as a sensitive tool in the characterization of cream samples. Regarding the correlation between physical measurements and certain sensory attributes, it is possible to formulate a product with specific sensory characteristics by using pre-defined rheological or textural parameters. To obtain a complete sensory profile of a cosmetic product, a detailed sensory evaluation should be carried out according to the existing standard practices, which are both time- and money-consuming. However, a modified sensory study could be useful for fast in-line screening along with instrumental characterization of a novel cosmetic emulsion product and could be particularly helpful in the process of distinguishing a single formulation from several differing in one component.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "International Journal of Cosmetic Science",
title = "A combined approach in characterization of an effective w/o hand cream: the influence of emollient on textural, sensorial and in vivo skin performance",
volume = "34",
number = "2",
pages = "140-149",
doi = "10.1111/j.1468-2494.2011.00693.x"
}

Lukić, M., Jaksić, I., Krstonosić, V., Cekić, N.,& Savić, S.. (2012). A combined approach in characterization of an effective w/o hand cream: the influence of emollient on textural, sensorial and in vivo skin performance. in International Journal of Cosmetic Science
Wiley-Blackwell, Hoboken., 34(2), 140-149.
https://doi.org/10.1111/j.1468-2494.2011.00693.x

Lukić M, Jaksić I, Krstonosić V, Cekić N, Savić S. A combined approach in characterization of an effective w/o hand cream: the influence of emollient on textural, sensorial and in vivo skin performance. in International Journal of Cosmetic Science. 2012;34(2):140-149.
doi:10.1111/j.1468-2494.2011.00693.x .

Lukić, Milica, Jaksić, I., Krstonosić, Veljko, Cekić, Nebojša, Savić, Snežana, "A combined approach in characterization of an effective w/o hand cream: the influence of emollient on textural, sensorial and in vivo skin performance" in International Journal of Cosmetic Science, 34, no. 2 (2012):140-149,
https://doi.org/10.1111/j.1468-2494.2011.00693.x . .

TY  - JOUR
AU  - Tasić-Kostov, Marija
AU  - Pavlović, Dragana R.
AU  - Lukić, Milica
AU  - Jaksić, I.
AU  - Arsić, I.
AU  - Savić, Snežana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1643
AB  - Synopsis Cosmeceutical antioxidants may protect the skin against oxidative injury, involved in the pathogenesis of many skin disorders. However, an unsuitable topical delivery system with compromising safety profile can affect the efficacy of an antioxidant active. This study investigated the antioxidant potential of lactobionic acid (LA), a newer cosmeceutical active, per se (in solution) and incorporated into natural alkyl polyglucoside (APG) emulsifier-based system using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and lipid peroxidation inhibition assays. The a-tocopherol was used as a reference compound. The physical stability (using rheology, polarization microscopy, pH and conductivity measurements) of an Alkyl glucoside-based emulsion was evaluated with and without the active (LA); colloidal structure was assessed using polarization and transmission electron microscopy, rheology, thermal and texture analysis. Additionally, the safety profile and moisturizing potential were investigated using the methods of skin bioengineering. Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle. LA per se and in APG-based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin. Employed assays were shown as suitable for the antioxidant activity evaluation of LA in APG-based emulsions, but not for a-tocopherol in the same vehicle.
PB  - Wiley-Blackwell, Hoboken
T2  - International Journal of Cosmetic Science
T1  - Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation
VL  - 34
IS  - 5
SP  - 424
EP  - 434
DO  - 10.1111/j.1468-2494.2012.00732.x
ER  - 

@article{
author = "Tasić-Kostov, Marija and Pavlović, Dragana R. and Lukić, Milica and Jaksić, I. and Arsić, I. and Savić, Snežana",
year = "2012",
abstract = "Synopsis Cosmeceutical antioxidants may protect the skin against oxidative injury, involved in the pathogenesis of many skin disorders. However, an unsuitable topical delivery system with compromising safety profile can affect the efficacy of an antioxidant active. This study investigated the antioxidant potential of lactobionic acid (LA), a newer cosmeceutical active, per se (in solution) and incorporated into natural alkyl polyglucoside (APG) emulsifier-based system using 1,1-diphenyl-2-picrylhydrazyl free radical scavenging and lipid peroxidation inhibition assays. The a-tocopherol was used as a reference compound. The physical stability (using rheology, polarization microscopy, pH and conductivity measurements) of an Alkyl glucoside-based emulsion was evaluated with and without the active (LA); colloidal structure was assessed using polarization and transmission electron microscopy, rheology, thermal and texture analysis. Additionally, the safety profile and moisturizing potential were investigated using the methods of skin bioengineering. Good physical stability and applicative characteristics were obtained although LA strongly influenced the colloidal structure of the vehicle. LA per se and in APG-based emulsion showed satisfying antioxidant activity that promotes it as mild multifunctional cosmeceutical efficient in the treatment and prevention of the photoaged skin. Employed assays were shown as suitable for the antioxidant activity evaluation of LA in APG-based emulsions, but not for a-tocopherol in the same vehicle.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "International Journal of Cosmetic Science",
title = "Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation",
volume = "34",
number = "5",
pages = "424-434",
doi = "10.1111/j.1468-2494.2012.00732.x"
}

Tasić-Kostov, M., Pavlović, D. R., Lukić, M., Jaksić, I., Arsić, I.,& Savić, S.. (2012). Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation. in International Journal of Cosmetic Science
Wiley-Blackwell, Hoboken., 34(5), 424-434.
https://doi.org/10.1111/j.1468-2494.2012.00732.x

Tasić-Kostov M, Pavlović DR, Lukić M, Jaksić I, Arsić I, Savić S. Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation. in International Journal of Cosmetic Science. 2012;34(5):424-434.
doi:10.1111/j.1468-2494.2012.00732.x .

Tasić-Kostov, Marija, Pavlović, Dragana R., Lukić, Milica, Jaksić, I., Arsić, I., Savić, Snežana, "Lactobionic acid as antioxidant and moisturizing active in alkyl polyglucoside-based topical emulsions: the colloidal structure, stability and efficacy evaluation" in International Journal of Cosmetic Science, 34, no. 5 (2012):424-434,
https://doi.org/10.1111/j.1468-2494.2012.00732.x . .

TY  - JOUR
AU  - Tasić-Kostov, Marija
AU  - Reichl, Stephan
AU  - Lukić, Milica
AU  - Jaksić, I.
AU  - Savić, Snežana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1490
AB  - There is a growing need for research into new skin and environmentally-friendly actives and surfactants in the field of cosmetics. This paper focuses on different natural alkylpolyglucoside (APG) emulsifiers (cetearyl alcohol and coco glucoside; arachidyl behenyl alcohol and arachidyl glucoside), which can form lyotropic liquid crystals, in order to promote them as cosmetic excipients. APG-based emulsions as carriers for extremely hygroscopic and acidic cosmetic active, lactobionic acid (LA), belonging to alpha-hydroxy acids (AHAs) were also studied. In the first part of the study, physicochemical properties (assessed by rheology, polarization microscopy and pH and conductivity measurements) and in vitro safety profile (skin irritation test using a cytotoxicity assay) of vehicles were determined in order to compare and estimate their applicability as cosmetic excipients. In the second part, the same methods were conducted in order to establish how those emulsions perform as carriers for different percents of LA. The study showed that both vehicles based on different APGs could be promoted as cosmetic excipients. Either of the APG based emulsions could be vehicles for 6% LA. Cetearyl alcohol and coco glucoside, more hydrophillic emulsifier, is acceptable carrier for 10% LA due to better cytotoxicity profile. The importance of a better cytotoxicity profile without neglecting satisfying physical stability for cosmetic formulations was emphasized.
PB  - Servizi Editoriali Assoc Srl, Como
T2  - RSC Advances
T1  - Two alkyl polyglucoside natural surfactants varying in chain length in stabilization of lactobionic acid containing emulsions: physicochemical characterization and in vitro irritation potential assessment
VL  - 88
IS  - 4
SP  - 256
EP  - 264
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1490
ER  - 

@article{
author = "Tasić-Kostov, Marija and Reichl, Stephan and Lukić, Milica and Jaksić, I. and Savić, Snežana",
year = "2011",
abstract = "There is a growing need for research into new skin and environmentally-friendly actives and surfactants in the field of cosmetics. This paper focuses on different natural alkylpolyglucoside (APG) emulsifiers (cetearyl alcohol and coco glucoside; arachidyl behenyl alcohol and arachidyl glucoside), which can form lyotropic liquid crystals, in order to promote them as cosmetic excipients. APG-based emulsions as carriers for extremely hygroscopic and acidic cosmetic active, lactobionic acid (LA), belonging to alpha-hydroxy acids (AHAs) were also studied. In the first part of the study, physicochemical properties (assessed by rheology, polarization microscopy and pH and conductivity measurements) and in vitro safety profile (skin irritation test using a cytotoxicity assay) of vehicles were determined in order to compare and estimate their applicability as cosmetic excipients. In the second part, the same methods were conducted in order to establish how those emulsions perform as carriers for different percents of LA. The study showed that both vehicles based on different APGs could be promoted as cosmetic excipients. Either of the APG based emulsions could be vehicles for 6% LA. Cetearyl alcohol and coco glucoside, more hydrophillic emulsifier, is acceptable carrier for 10% LA due to better cytotoxicity profile. The importance of a better cytotoxicity profile without neglecting satisfying physical stability for cosmetic formulations was emphasized.",
publisher = "Servizi Editoriali Assoc Srl, Como",
journal = "RSC Advances",
title = "Two alkyl polyglucoside natural surfactants varying in chain length in stabilization of lactobionic acid containing emulsions: physicochemical characterization and in vitro irritation potential assessment",
volume = "88",
number = "4",
pages = "256-264",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1490"
}

Tasić-Kostov, M., Reichl, S., Lukić, M., Jaksić, I.,& Savić, S.. (2011). Two alkyl polyglucoside natural surfactants varying in chain length in stabilization of lactobionic acid containing emulsions: physicochemical characterization and in vitro irritation potential assessment. in RSC Advances
Servizi Editoriali Assoc Srl, Como., 88(4), 256-264.
https://hdl.handle.net/21.15107/rcub_farfar_1490

Tasić-Kostov M, Reichl S, Lukić M, Jaksić I, Savić S. Two alkyl polyglucoside natural surfactants varying in chain length in stabilization of lactobionic acid containing emulsions: physicochemical characterization and in vitro irritation potential assessment. in RSC Advances. 2011;88(4):256-264.
https://hdl.handle.net/21.15107/rcub_farfar_1490 .

Tasić-Kostov, Marija, Reichl, Stephan, Lukić, Milica, Jaksić, I., Savić, Snežana, "Two alkyl polyglucoside natural surfactants varying in chain length in stabilization of lactobionic acid containing emulsions: physicochemical characterization and in vitro irritation potential assessment" in RSC Advances, 88, no. 4 (2011):256-264,
https://hdl.handle.net/21.15107/rcub_farfar_1490 .