TY  - JOUR
AU  - Pantelić, Ivana
AU  - Lukić, Milica
AU  - Malenović, Anđelija
AU  - Reichl, Stephan
AU  - Hoffmann, Christine
AU  - Mueller-Goymann, Christel
AU  - Daniels, Rolf
AU  - Savić, Snežana
PY  - 2012
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1721
AB  - Recently, healthcare professionals again began realizing the benefits of preparing customized medications to meet specific patient needs. The objective of this work was to develop and evaluate simple pharmaceutical bases stabilized with natural-origin surfactant of alkyl polyglucoside (APG) type as prospective ready-to-use bases and compare them to widely used pharmacopoeial ones. Additionally, the ability of the formulated bases to sustain isopropyl alcohol was assessed as well as its influence on ketoprofen skin absorption (as a co-solvent and potential penetration enhancer). In order to evaluate the manifold characteristics a topical drug product should possess, a comprehensive characterization was performed using different techniques. Physicochemical characterization demonstrated satisfactory physical stability of APG-stabilized bases upon the addition of alcohol. In vitro release/permeation studies failed to show significant difference in ketoprofen liberation/permeation profiles from different bases. However, the extent of ketoprofen delivery in vivo was clearly increased from APG bases, relative to that obtained from pharmacopoeia quality one, implying a distinct influence of the emulsion systems' colloidal structures. Taking also into account the rheological behavior of APG bases, revealing their ameliorated sensory characteristics, it could be concluded that the investigated APG bases could be considered as preferential option in drug compounding related to the conventional ones.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutics and Biopharmaceutics
T1  - Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study
VL  - 80
IS  - 1
SP  - 164
EP  - 175
DO  - 10.1016/j.ejpb.2011.09.001
ER  - 

@article{
author = "Pantelić, Ivana and Lukić, Milica and Malenović, Anđelija and Reichl, Stephan and Hoffmann, Christine and Mueller-Goymann, Christel and Daniels, Rolf and Savić, Snežana",
year = "2012",
abstract = "Recently, healthcare professionals again began realizing the benefits of preparing customized medications to meet specific patient needs. The objective of this work was to develop and evaluate simple pharmaceutical bases stabilized with natural-origin surfactant of alkyl polyglucoside (APG) type as prospective ready-to-use bases and compare them to widely used pharmacopoeial ones. Additionally, the ability of the formulated bases to sustain isopropyl alcohol was assessed as well as its influence on ketoprofen skin absorption (as a co-solvent and potential penetration enhancer). In order to evaluate the manifold characteristics a topical drug product should possess, a comprehensive characterization was performed using different techniques. Physicochemical characterization demonstrated satisfactory physical stability of APG-stabilized bases upon the addition of alcohol. In vitro release/permeation studies failed to show significant difference in ketoprofen liberation/permeation profiles from different bases. However, the extent of ketoprofen delivery in vivo was clearly increased from APG bases, relative to that obtained from pharmacopoeia quality one, implying a distinct influence of the emulsion systems' colloidal structures. Taking also into account the rheological behavior of APG bases, revealing their ameliorated sensory characteristics, it could be concluded that the investigated APG bases could be considered as preferential option in drug compounding related to the conventional ones.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutics and Biopharmaceutics",
title = "Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study",
volume = "80",
number = "1",
pages = "164-175",
doi = "10.1016/j.ejpb.2011.09.001"
}

Pantelić, I., Lukić, M., Malenović, A., Reichl, S., Hoffmann, C., Mueller-Goymann, C., Daniels, R.,& Savić, S.. (2012). Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study. in European Journal of Pharmaceutics and Biopharmaceutics
Elsevier Science BV, Amsterdam., 80(1), 164-175.
https://doi.org/10.1016/j.ejpb.2011.09.001

Pantelić I, Lukić M, Malenović A, Reichl S, Hoffmann C, Mueller-Goymann C, Daniels R, Savić S. Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study. in European Journal of Pharmaceutics and Biopharmaceutics. 2012;80(1):164-175.
doi:10.1016/j.ejpb.2011.09.001 .

Pantelić, Ivana, Lukić, Milica, Malenović, Anđelija, Reichl, Stephan, Hoffmann, Christine, Mueller-Goymann, Christel, Daniels, Rolf, Savić, Snežana, "Compounding of a topical drug with prospective natural surfactant-stabilized pharmaceutical bases: Physicochemical and in vitro/in vivo characterization - A ketoprofen case study" in European Journal of Pharmaceutics and Biopharmaceutics, 80, no. 1 (2012):164-175,
https://doi.org/10.1016/j.ejpb.2011.09.001 . .

TY  - JOUR
AU  - Savić, Snežana
AU  - Lukić, Milica
AU  - Pantelić, Ivana
AU  - Reichl, Stephan
AU  - Tamburić, Slobodanka
AU  - Mueller-Goymann, Christel
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1533
AB  - To be considered as a suitable vehicle for drugs/cosmetic actives, an emulsion system should have a number of desirable properties mainly dependent on surfactant used for its stabilization. In the current study, C12-14 alkyl polyglucoside (APG)-mixed emulsifier of natural origin has been investigated in a series of binary (emulsifier concentration 10-25% (w/w)) and ternary systems with fixed emulsifier content (15% (w/w)) with or without glycerol. To elucidate the systems' colloidal structure the following physicochemical techniques were employed: polarization and transmission electron microscopy, X-ray diffraction (WAXD and SAXD), thermal analysis (DSC and TGA), complex rheological, pH, and conductivity measurements. Additionally, the emulsion vehicles' skin hydration potential was tested in vivo, on human skin under occlusion. In a series of binary systems with fixed emulsifier/water ratios ranging from 10/90 to 25/75 the predominance of a lamellar mesophase was found, changing its character from a liquid crystalline to a gel crystalline type. The same was observed in gel emulsions containing equal amounts of emulsifier and oil (15% (w/w)), but varying in glycerol content (0-25%). Different emulsion samples exhibited different water distribution modes in the structure, reflecting their rheological behavior and also their skin hydration capacity.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Journal of Colloid and Interface Science
T1  - An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential
VL  - 358
IS  - 1
SP  - 182
EP  - 191
DO  - 10.1016/j.jcis.2011.02.049
ER  - 

@article{
author = "Savić, Snežana and Lukić, Milica and Pantelić, Ivana and Reichl, Stephan and Tamburić, Slobodanka and Mueller-Goymann, Christel",
year = "2011",
abstract = "To be considered as a suitable vehicle for drugs/cosmetic actives, an emulsion system should have a number of desirable properties mainly dependent on surfactant used for its stabilization. In the current study, C12-14 alkyl polyglucoside (APG)-mixed emulsifier of natural origin has been investigated in a series of binary (emulsifier concentration 10-25% (w/w)) and ternary systems with fixed emulsifier content (15% (w/w)) with or without glycerol. To elucidate the systems' colloidal structure the following physicochemical techniques were employed: polarization and transmission electron microscopy, X-ray diffraction (WAXD and SAXD), thermal analysis (DSC and TGA), complex rheological, pH, and conductivity measurements. Additionally, the emulsion vehicles' skin hydration potential was tested in vivo, on human skin under occlusion. In a series of binary systems with fixed emulsifier/water ratios ranging from 10/90 to 25/75 the predominance of a lamellar mesophase was found, changing its character from a liquid crystalline to a gel crystalline type. The same was observed in gel emulsions containing equal amounts of emulsifier and oil (15% (w/w)), but varying in glycerol content (0-25%). Different emulsion samples exhibited different water distribution modes in the structure, reflecting their rheological behavior and also their skin hydration capacity.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Journal of Colloid and Interface Science",
title = "An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential",
volume = "358",
number = "1",
pages = "182-191",
doi = "10.1016/j.jcis.2011.02.049"
}

Savić, S., Lukić, M., Pantelić, I., Reichl, S., Tamburić, S.,& Mueller-Goymann, C.. (2011). An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential. in Journal of Colloid and Interface Science
Academic Press Inc Elsevier Science, San Diego., 358(1), 182-191.
https://doi.org/10.1016/j.jcis.2011.02.049

Savić S, Lukić M, Pantelić I, Reichl S, Tamburić S, Mueller-Goymann C. An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential. in Journal of Colloid and Interface Science. 2011;358(1):182-191.
doi:10.1016/j.jcis.2011.02.049 .

Savić, Snežana, Lukić, Milica, Pantelić, Ivana, Reichl, Stephan, Tamburić, Slobodanka, Mueller-Goymann, Christel, "An alkyl polyglucoside-mixed emulsifier as stabilizer of emulsion systems: The influence of colloidal structure on emulsions skin hydration potential" in Journal of Colloid and Interface Science, 358, no. 1 (2011):182-191,
https://doi.org/10.1016/j.jcis.2011.02.049 . .

TY  - JOUR
AU  - Tasić-Kostov, Marija
AU  - Reichl, Stephan
AU  - Lukić, Milica
AU  - Jaksić, I. N.
AU  - Savić, Snežana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1513
AB  - Moisturizing creams are the most prescribed products in dermatology, essential in maintaining healthy skin as well as in the topical treatment of some diseases. The irritation potential of commonly used emulsifiers and moisturizing ingredients, but also their mutual interactions, could affect the functionality and safety of those dermopharmaceutics. The aim of this study was to promote moisturizing alkyl polyglucoside (APG)-based emulsion as vehicle for lactobionic acid (LA), advantageous representative of the alphahydroxyacids (AHAs)-multifunctional moisturizers, assessing the safety for use (in vitro acute skin irritation test using cytotoxicity assay compared with in vivo data obtained using skin bioengineering methods) and in vivo moisturizing capacity (bioengineering of the skin). In order to investigate possible interactions between APG mild natural emulsifier-based emulsion and LA, a deeper insight into the colloidal structure of the placebo and the emulsion with LA was given using polarization and transmission electron microscopy, rheology, thermal and texture analysis. This study showed that APG-based emulsions could be promoted as safe cosmetic/dermopharmaceutical vehicles and carriers for extremely acidic and hygroscopic AHA class of actives (specifically LA); prospective safety for human use of both APG and LA with the correlation between in vivo and in vitro findings was shown. However, it was revealed that LA strongly influenced the colloidal structure of the emulsion based on APGs and promoted the formation of lamellar structures which reflects onto the mode of water distribution within the cream. The advantageous skin hydrating potential of LA-containing emulsion vs. placebo was unlikely to be achieved, pointing that emulsions stabilized by lamellar liquid crystalline structures probably are not satisfying carriers for highly hygroscopic actives in order to reach the full moisturizing potential. Safe and effective use on dry skin is presumed.
PB  - Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn
T2  - Pharmazie
T1  - Does lactobionic acid affect the colloidal structure and skin moisturizing potential of the alkyl polyglucoside-based emulsion systems?
VL  - 66
IS  - 11
SP  - 862
EP  - 870
DO  - 10.1691/ph.2011.1066
ER  - 

@article{
author = "Tasić-Kostov, Marija and Reichl, Stephan and Lukić, Milica and Jaksić, I. N. and Savić, Snežana",
year = "2011",
abstract = "Moisturizing creams are the most prescribed products in dermatology, essential in maintaining healthy skin as well as in the topical treatment of some diseases. The irritation potential of commonly used emulsifiers and moisturizing ingredients, but also their mutual interactions, could affect the functionality and safety of those dermopharmaceutics. The aim of this study was to promote moisturizing alkyl polyglucoside (APG)-based emulsion as vehicle for lactobionic acid (LA), advantageous representative of the alphahydroxyacids (AHAs)-multifunctional moisturizers, assessing the safety for use (in vitro acute skin irritation test using cytotoxicity assay compared with in vivo data obtained using skin bioengineering methods) and in vivo moisturizing capacity (bioengineering of the skin). In order to investigate possible interactions between APG mild natural emulsifier-based emulsion and LA, a deeper insight into the colloidal structure of the placebo and the emulsion with LA was given using polarization and transmission electron microscopy, rheology, thermal and texture analysis. This study showed that APG-based emulsions could be promoted as safe cosmetic/dermopharmaceutical vehicles and carriers for extremely acidic and hygroscopic AHA class of actives (specifically LA); prospective safety for human use of both APG and LA with the correlation between in vivo and in vitro findings was shown. However, it was revealed that LA strongly influenced the colloidal structure of the emulsion based on APGs and promoted the formation of lamellar structures which reflects onto the mode of water distribution within the cream. The advantageous skin hydrating potential of LA-containing emulsion vs. placebo was unlikely to be achieved, pointing that emulsions stabilized by lamellar liquid crystalline structures probably are not satisfying carriers for highly hygroscopic actives in order to reach the full moisturizing potential. Safe and effective use on dry skin is presumed.",
publisher = "Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn",
journal = "Pharmazie",
title = "Does lactobionic acid affect the colloidal structure and skin moisturizing potential of the alkyl polyglucoside-based emulsion systems?",
volume = "66",
number = "11",
pages = "862-870",
doi = "10.1691/ph.2011.1066"
}

Tasić-Kostov, M., Reichl, S., Lukić, M., Jaksić, I. N.,& Savić, S.. (2011). Does lactobionic acid affect the colloidal structure and skin moisturizing potential of the alkyl polyglucoside-based emulsion systems?. in Pharmazie
Govi-Verlag  Pharmazeutischer Verlag Gmbh, Eschborn., 66(11), 862-870.
https://doi.org/10.1691/ph.2011.1066

Tasić-Kostov M, Reichl S, Lukić M, Jaksić IN, Savić S. Does lactobionic acid affect the colloidal structure and skin moisturizing potential of the alkyl polyglucoside-based emulsion systems?. in Pharmazie. 2011;66(11):862-870.
doi:10.1691/ph.2011.1066 .

Tasić-Kostov, Marija, Reichl, Stephan, Lukić, Milica, Jaksić, I. N., Savić, Snežana, "Does lactobionic acid affect the colloidal structure and skin moisturizing potential of the alkyl polyglucoside-based emulsion systems?" in Pharmazie, 66, no. 11 (2011):862-870,
https://doi.org/10.1691/ph.2011.1066 . .

TY  - JOUR
AU  - Tasić-Kostov, Marija
AU  - Reichl, Stephan
AU  - Lukić, Milica
AU  - Jaksić, I.
AU  - Savić, Snežana
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1490
AB  - There is a growing need for research into new skin and environmentally-friendly actives and surfactants in the field of cosmetics. This paper focuses on different natural alkylpolyglucoside (APG) emulsifiers (cetearyl alcohol and coco glucoside; arachidyl behenyl alcohol and arachidyl glucoside), which can form lyotropic liquid crystals, in order to promote them as cosmetic excipients. APG-based emulsions as carriers for extremely hygroscopic and acidic cosmetic active, lactobionic acid (LA), belonging to alpha-hydroxy acids (AHAs) were also studied. In the first part of the study, physicochemical properties (assessed by rheology, polarization microscopy and pH and conductivity measurements) and in vitro safety profile (skin irritation test using a cytotoxicity assay) of vehicles were determined in order to compare and estimate their applicability as cosmetic excipients. In the second part, the same methods were conducted in order to establish how those emulsions perform as carriers for different percents of LA. The study showed that both vehicles based on different APGs could be promoted as cosmetic excipients. Either of the APG based emulsions could be vehicles for 6% LA. Cetearyl alcohol and coco glucoside, more hydrophillic emulsifier, is acceptable carrier for 10% LA due to better cytotoxicity profile. The importance of a better cytotoxicity profile without neglecting satisfying physical stability for cosmetic formulations was emphasized.
PB  - Servizi Editoriali Assoc Srl, Como
T2  - RSC Advances
T1  - Two alkyl polyglucoside natural surfactants varying in chain length in stabilization of lactobionic acid containing emulsions: physicochemical characterization and in vitro irritation potential assessment
VL  - 88
IS  - 4
SP  - 256
EP  - 264
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1490
ER  - 

@article{
author = "Tasić-Kostov, Marija and Reichl, Stephan and Lukić, Milica and Jaksić, I. and Savić, Snežana",
year = "2011",
abstract = "There is a growing need for research into new skin and environmentally-friendly actives and surfactants in the field of cosmetics. This paper focuses on different natural alkylpolyglucoside (APG) emulsifiers (cetearyl alcohol and coco glucoside; arachidyl behenyl alcohol and arachidyl glucoside), which can form lyotropic liquid crystals, in order to promote them as cosmetic excipients. APG-based emulsions as carriers for extremely hygroscopic and acidic cosmetic active, lactobionic acid (LA), belonging to alpha-hydroxy acids (AHAs) were also studied. In the first part of the study, physicochemical properties (assessed by rheology, polarization microscopy and pH and conductivity measurements) and in vitro safety profile (skin irritation test using a cytotoxicity assay) of vehicles were determined in order to compare and estimate their applicability as cosmetic excipients. In the second part, the same methods were conducted in order to establish how those emulsions perform as carriers for different percents of LA. The study showed that both vehicles based on different APGs could be promoted as cosmetic excipients. Either of the APG based emulsions could be vehicles for 6% LA. Cetearyl alcohol and coco glucoside, more hydrophillic emulsifier, is acceptable carrier for 10% LA due to better cytotoxicity profile. The importance of a better cytotoxicity profile without neglecting satisfying physical stability for cosmetic formulations was emphasized.",
publisher = "Servizi Editoriali Assoc Srl, Como",
journal = "RSC Advances",
title = "Two alkyl polyglucoside natural surfactants varying in chain length in stabilization of lactobionic acid containing emulsions: physicochemical characterization and in vitro irritation potential assessment",
volume = "88",
number = "4",
pages = "256-264",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1490"
}

Tasić-Kostov, M., Reichl, S., Lukić, M., Jaksić, I.,& Savić, S.. (2011). Two alkyl polyglucoside natural surfactants varying in chain length in stabilization of lactobionic acid containing emulsions: physicochemical characterization and in vitro irritation potential assessment. in RSC Advances
Servizi Editoriali Assoc Srl, Como., 88(4), 256-264.
https://hdl.handle.net/21.15107/rcub_farfar_1490

Tasić-Kostov M, Reichl S, Lukić M, Jaksić I, Savić S. Two alkyl polyglucoside natural surfactants varying in chain length in stabilization of lactobionic acid containing emulsions: physicochemical characterization and in vitro irritation potential assessment. in RSC Advances. 2011;88(4):256-264.
https://hdl.handle.net/21.15107/rcub_farfar_1490 .

Tasić-Kostov, Marija, Reichl, Stephan, Lukić, Milica, Jaksić, I., Savić, Snežana, "Two alkyl polyglucoside natural surfactants varying in chain length in stabilization of lactobionic acid containing emulsions: physicochemical characterization and in vitro irritation potential assessment" in RSC Advances, 88, no. 4 (2011):256-264,
https://hdl.handle.net/21.15107/rcub_farfar_1490 .