TY  - CONF
AU  - Ćirić, Ana
AU  - Lukić, Milica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5351
AB  - Due to sustainability requirements, a particular interest is focused on cosmetic ingredients derived from plant waste materials (1).  ...
PB  - APGI – “Association de Pharmacie Galénique Industrielle”
C3  - 6th Symposium Skin and Formulation, 2-3 October, 2023, Nantes - France
T1  - Waste materials from wheat, corn and sunflower in cosmetic products
SP  - 61
EP  - 61
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5351
ER  - 

@conference{
author = "Ćirić, Ana and Lukić, Milica",
year = "2023",
abstract = "Due to sustainability requirements, a particular interest is focused on cosmetic ingredients derived from plant waste materials (1).  ...",
publisher = "APGI – “Association de Pharmacie Galénique Industrielle”",
journal = "6th Symposium Skin and Formulation, 2-3 October, 2023, Nantes - France",
title = "Waste materials from wheat, corn and sunflower in cosmetic products",
pages = "61-61",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5351"
}

Ćirić, A.,& Lukić, M.. (2023). Waste materials from wheat, corn and sunflower in cosmetic products. in 6th Symposium Skin and Formulation, 2-3 October, 2023, Nantes - France
APGI – “Association de Pharmacie Galénique Industrielle”., 61-61.
https://hdl.handle.net/21.15107/rcub_farfar_5351

Ćirić A, Lukić M. Waste materials from wheat, corn and sunflower in cosmetic products. in 6th Symposium Skin and Formulation, 2-3 October, 2023, Nantes - France. 2023;:61-61.
https://hdl.handle.net/21.15107/rcub_farfar_5351 .

Ćirić, Ana, Lukić, Milica, "Waste materials from wheat, corn and sunflower in cosmetic products" in 6th Symposium Skin and Formulation, 2-3 October, 2023, Nantes - France (2023):61-61,
https://hdl.handle.net/21.15107/rcub_farfar_5351 .

TY  - CONF
AU  - Ćirić, Ana
AU  - Božić, Dragana
AU  - Filipović, Mila
AU  - Lukić, Milica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5350
AB  - An important contribution to sustainability is research into the usability of ingredients from waste materials (1). Therefore, the aim of our work was to investigate the contribution of ethanol extracts from wheat, corn, ...
PB  - APGI – “Association de Pharmacie Galénique Industrielle”
C3  - 6th Symposium Skin and Formulation, 2-3 October, 2023, Nantes - France
T1  - Contribution of ethanol extracts from wheat, corn and sunflower waste material to the properties and effects of cosmetic products
SP  - 48
EP  - 48
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5350
ER  - 

@conference{
author = "Ćirić, Ana and Božić, Dragana and Filipović, Mila and Lukić, Milica",
year = "2023",
abstract = "An important contribution to sustainability is research into the usability of ingredients from waste materials (1). Therefore, the aim of our work was to investigate the contribution of ethanol extracts from wheat, corn, ...",
publisher = "APGI – “Association de Pharmacie Galénique Industrielle”",
journal = "6th Symposium Skin and Formulation, 2-3 October, 2023, Nantes - France",
title = "Contribution of ethanol extracts from wheat, corn and sunflower waste material to the properties and effects of cosmetic products",
pages = "48-48",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5350"
}

Ćirić, A., Božić, D., Filipović, M.,& Lukić, M.. (2023). Contribution of ethanol extracts from wheat, corn and sunflower waste material to the properties and effects of cosmetic products. in 6th Symposium Skin and Formulation, 2-3 October, 2023, Nantes - France
APGI – “Association de Pharmacie Galénique Industrielle”., 48-48.
https://hdl.handle.net/21.15107/rcub_farfar_5350

Ćirić A, Božić D, Filipović M, Lukić M. Contribution of ethanol extracts from wheat, corn and sunflower waste material to the properties and effects of cosmetic products. in 6th Symposium Skin and Formulation, 2-3 October, 2023, Nantes - France. 2023;:48-48.
https://hdl.handle.net/21.15107/rcub_farfar_5350 .

Ćirić, Ana, Božić, Dragana, Filipović, Mila, Lukić, Milica, "Contribution of ethanol extracts from wheat, corn and sunflower waste material to the properties and effects of cosmetic products" in 6th Symposium Skin and Formulation, 2-3 October, 2023, Nantes - France (2023):48-48,
https://hdl.handle.net/21.15107/rcub_farfar_5350 .

TY  - JOUR
AU  - Kurćubić, Ivana
AU  - Cvijić, Sandra
AU  - Lukić, Milica
AU  - Ibrić, Svetlana
AU  - Đuriš, Jelena
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3878
AB  - The development of solid dosage forms that are both convenient for administration and allow precise drug dosing for pediatric patients is one of the great challenges in contemporary pharmaceutical technology. The presented study has utilized propranolol hydrochloride, as one of the most frequently prescribed drugs that require manipulation of the conventional dosage forms to be administered to children. Multiparticulate oral formulations, powder- and granule-filled capsules, as well as mini tablets, were prepared and characterized in terms of their mass and content uniformity and compared to conventional marketed tablets split into halves and quarters. The obtained results have demonstrated the superiority of the multiparticulate formulations, in terms of their average mass and drug content uniformity. It has also been demonstrated that, due to improved flowability, granule-filled capsules are more conveniently compounded and provide higher  content  uniformity  compared  to  powder-filled  capsules.  The  presented  compounding method could be easily employed in community pharmacy settings. Mini tablets with high and uniform  content  of  propranolol  hydrochloride  have  been  successfully  prepared,  thereby presenting a viable strategy for efficient drug dose adjustment.
AB  - Razvoj čvrstih farmaceutskih oblika lekova koji su prikladni za primenu kod pedijatrijske populacije pacijenata, ali koji istovremeno omogućavaju i precizno doziranje lekovite supstance, predstavlja jedan od vodećih izazova u farmaceutskoj tehnologiji. Prikazana studija koristi propranolol-hidrohlorid, kao jedan od najčešće primenjivanih lekova koji zahteva prilagođavanje farmaceutskih oblika za primenu kod dece. Višečestični farmaceutski oblici u vidu kapsula napunjenih praškom ili granulama, kao i mini tablete, su izrađene i ispitane u pogledu variranja mase i ujednačenosti sadržaja lekovite supstance. Dobijeni rezultati su upoređeni sa variranjem mase uzoraka koji se dobijaju deljenjem konvencionalnih registrovanih tableta na polovine i četvrtine. Dobijeni rezultati ukazuju na superiornost višečestičnih farmaceutskih oblika, zbog visokog stepena ujednačenosti mase i sadržaja lekovite supstance. Takođe je pokazano da se, zbog unapređene protočnosti, kapsule lakše pune granulama u odnosu na praškove, kao i da takvi farmaceutski oblici imaju veću ujednačenost mase i sadržaja lekovite supstance. Predstavljeni postupak izrade je jednostavan za izvođenje u uslovima apoteke. Mini tablete sa visokim udelom i ujednačenim sadržajem propranolol-hidrohlorida su uspešno izrađene, i predstavljaju značajnu strategiju koja može da omogući efikasno prilagođavanje doze lekovite supstance.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Multiparticulate oral formulations as a viable strategy for precise drug dosing in pediatrics: propranolol case study
T1  - Višečestične formulacije lekova za oralnu primenu kao strategija za precizno doziranje kod pedijatrijskih pacijenata - studija slučaja propranolola
VL  - 71
IS  - 2
SP  - 141
EP  - 159
DO  - 10.5937/arhfarm71‐30717
ER  - 

@article{
author = "Kurćubić, Ivana and Cvijić, Sandra and Lukić, Milica and Ibrić, Svetlana and Đuriš, Jelena",
year = "2021",
abstract = "The development of solid dosage forms that are both convenient for administration and allow precise drug dosing for pediatric patients is one of the great challenges in contemporary pharmaceutical technology. The presented study has utilized propranolol hydrochloride, as one of the most frequently prescribed drugs that require manipulation of the conventional dosage forms to be administered to children. Multiparticulate oral formulations, powder- and granule-filled capsules, as well as mini tablets, were prepared and characterized in terms of their mass and content uniformity and compared to conventional marketed tablets split into halves and quarters. The obtained results have demonstrated the superiority of the multiparticulate formulations, in terms of their average mass and drug content uniformity. It has also been demonstrated that, due to improved flowability, granule-filled capsules are more conveniently compounded and provide higher  content  uniformity  compared  to  powder-filled  capsules.  The  presented  compounding method could be easily employed in community pharmacy settings. Mini tablets with high and uniform  content  of  propranolol  hydrochloride  have  been  successfully  prepared,  thereby presenting a viable strategy for efficient drug dose adjustment., Razvoj čvrstih farmaceutskih oblika lekova koji su prikladni za primenu kod pedijatrijske populacije pacijenata, ali koji istovremeno omogućavaju i precizno doziranje lekovite supstance, predstavlja jedan od vodećih izazova u farmaceutskoj tehnologiji. Prikazana studija koristi propranolol-hidrohlorid, kao jedan od najčešće primenjivanih lekova koji zahteva prilagođavanje farmaceutskih oblika za primenu kod dece. Višečestični farmaceutski oblici u vidu kapsula napunjenih praškom ili granulama, kao i mini tablete, su izrađene i ispitane u pogledu variranja mase i ujednačenosti sadržaja lekovite supstance. Dobijeni rezultati su upoređeni sa variranjem mase uzoraka koji se dobijaju deljenjem konvencionalnih registrovanih tableta na polovine i četvrtine. Dobijeni rezultati ukazuju na superiornost višečestičnih farmaceutskih oblika, zbog visokog stepena ujednačenosti mase i sadržaja lekovite supstance. Takođe je pokazano da se, zbog unapređene protočnosti, kapsule lakše pune granulama u odnosu na praškove, kao i da takvi farmaceutski oblici imaju veću ujednačenost mase i sadržaja lekovite supstance. Predstavljeni postupak izrade je jednostavan za izvođenje u uslovima apoteke. Mini tablete sa visokim udelom i ujednačenim sadržajem propranolol-hidrohlorida su uspešno izrađene, i predstavljaju značajnu strategiju koja može da omogući efikasno prilagođavanje doze lekovite supstance.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Multiparticulate oral formulations as a viable strategy for precise drug dosing in pediatrics: propranolol case study, Višečestične formulacije lekova za oralnu primenu kao strategija za precizno doziranje kod pedijatrijskih pacijenata - studija slučaja propranolola",
volume = "71",
number = "2",
pages = "141-159",
doi = "10.5937/arhfarm71‐30717"
}

Kurćubić, I., Cvijić, S., Lukić, M., Ibrić, S.,& Đuriš, J.. (2021). Multiparticulate oral formulations as a viable strategy for precise drug dosing in pediatrics: propranolol case study. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 71(2), 141-159.
https://doi.org/10.5937/arhfarm71‐30717

Kurćubić I, Cvijić S, Lukić M, Ibrić S, Đuriš J. Multiparticulate oral formulations as a viable strategy for precise drug dosing in pediatrics: propranolol case study. in Arhiv za farmaciju. 2021;71(2):141-159.
doi:10.5937/arhfarm71‐30717 .

Kurćubić, Ivana, Cvijić, Sandra, Lukić, Milica, Ibrić, Svetlana, Đuriš, Jelena, "Multiparticulate oral formulations as a viable strategy for precise drug dosing in pediatrics: propranolol case study" in Arhiv za farmaciju, 71, no. 2 (2021):141-159,
https://doi.org/10.5937/arhfarm71‐30717 . .

TY  - CONF
AU  - Todorović, Jelena
AU  - Lukić, Milica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4674
AB  - Microflora or microbiota is a term that describes millions of different organisms
(bacteria, yeasts, fungi, viruses) that live on human skin (1). The microbiome of human skin
has become the focus of the dermatological and cosmetic research, and latter studies suggest
that its’ maintenance is essential for healthy and good looking skin. Cosmetic products can
shape specific microbial communities of the skin by changing their chemical environment.
Cosmetic cleansing products are effective in maintaining skin hygiene and a healthy biofilm,
and special attention is given to antibacterial soaps which could eliminate both pathogenic
and beneficial microorganisms. Consequently, the reduction in the number of good bacteria
caused by the frequent use of antibacterial soaps can lead to negative effects on skin health
in the long run. A study evaluating the impact and effects of regular use of cosmetic products
on skin microbiome showed that cosmetic products alter bacterial diversity – inducing a
temporary change in the number and proportion of bacteria on the skin, this being specific
for the type of cosmetic product, the place of application and the person (2). The results
obtained in another study indicate that the use of synthetic ingredients could cause the
damage of skin microbiome (3). The cosmetics industry has focused on the production of
new cosmetic products that would affect the microbiome in order to improve the appearance
and condition of the skin, and the development of these products involves one of three basic
approaches: balancing or improvement of the skin microbiome, protection of skin
microbiome and activation of skin microbiome in order to achieve beneficial effects on the
skin. Data on the importance of microbiome and its metabolites in functioning of the skin
barrier drew the attention of cosmetic scientists to bacterial lysates, fermentation products
and metabolites to be used as cosmetic active ingredients that can achieve positive effects on
the skin in various types of cosmetics. The main challenges in the development of cosmetic
active ingredients and cosmetic products in the service of microbiome are their safety,
stability and efficacy investigation, and substation of microbiome claims for these products.
AB  - Mikroflora ili mikrobiota je termin koji opisuje milione različitih mikroorganizama
(bakterije, kvasci, gljivice, virusi) koji žive na ljudskoj koži (1). Mikrobiom ljudske kože
postao je fokus u oblasti dermatologije i kozmetologije, a brojna istraživanja upućuju na to da
je održavanje njegovog balansa od suštinskog značaja za zdravu kožu i njen lep izgled.
Kozmetički proizvodi mogu uticati na oblikovanje specifičnih mikrobnih zajednica kože usled
promena njihovog hemijskog okruženja. Kozmetički proizvodi za čišćenje kože su efikasni u
održavanju higijene kože i zdravog biofilma, a posebna pažnja posvećuje se antibakterijskim
sapunima, koji mogu eliminisati i patogene i korisne mikroorganizme. Shodno tome,
smanjenje broja dobrih bakterija izazvano čestom upotrebom antibakterijskih sapuna
dugoročno može dovesti do negativnih efekata na zdravlje kože. U studiji u kojoj je procenjen
uticaj i efekti redovne upotrebe kozmetičkih proizvoda na mikrobiom kože pokazano je da
kozmetički proizvodi menjaju mikrobiom utičući na bakterijski diverzitet, dovodeći do
privremenih promena u količini i odnosu prisutnih bakterija, pri čemu su promene specifične
za vrstu kozmetičkog proizvoda, mesto primene i osobu (2). U drugoj studiji dobijeni
rezultati ukazuju na to da upotreba sintetičkih sastojaka iz kozmetičkih proizvoda može
dovesti do oštećenja mikrobioma kože (3). Kozmetička industrija usmerila se na proizvodnju
novih kozmetičkih proizvoda koji bi delovanjem na mikrobiom uticali na poboljšanje izgleda
i stanja kože, a razvoj ovih proizvoda podrazumeva jedan od tri osnovna pristupa: pokušaj
balansiranja ili poboljšanja mikrobioma kože, zaštitu mikrobioma kože i aktiviranje
mikrobioma u ostvarivanju različitih efekata na koži. Podaci o značaju mikrobioma i njegovih
metabolita u funkcionisanju kožne barijere usmerile su pažnju kozmetologa na mogućnost
upotrebe bakterijskih lizata, fermentacionih produkata i metabolita, kao kozmetički aktivnih
sastojaka koji mogu ostvariti pozitivne efekte na kožu u različitim vrstama kozmetičkih
proizvoda. Glavni izazov u razvoju kozmetički aktivnih supstanci ili kozmetičkih proizvoda u
službi mikrobioma je ispitivanje njihove bezbednosti, stabilnosti i efikasnosti, odnosno
potkrepljivanje tvrdnji vezanih za ove proizvode odgovarajućim dokazima.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Skin microbiome and cosmetic products
T1  - Mikrobiom kože i kozmetički proizvodi
VL  - 71
IS  - 5 suplement
SP  - S100
EP  - S101
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4674
ER  - 

@conference{
author = "Todorović, Jelena and Lukić, Milica",
year = "2021",
abstract = "Microflora or microbiota is a term that describes millions of different organisms
(bacteria, yeasts, fungi, viruses) that live on human skin (1). The microbiome of human skin
has become the focus of the dermatological and cosmetic research, and latter studies suggest
that its’ maintenance is essential for healthy and good looking skin. Cosmetic products can
shape specific microbial communities of the skin by changing their chemical environment.
Cosmetic cleansing products are effective in maintaining skin hygiene and a healthy biofilm,
and special attention is given to antibacterial soaps which could eliminate both pathogenic
and beneficial microorganisms. Consequently, the reduction in the number of good bacteria
caused by the frequent use of antibacterial soaps can lead to negative effects on skin health
in the long run. A study evaluating the impact and effects of regular use of cosmetic products
on skin microbiome showed that cosmetic products alter bacterial diversity – inducing a
temporary change in the number and proportion of bacteria on the skin, this being specific
for the type of cosmetic product, the place of application and the person (2). The results
obtained in another study indicate that the use of synthetic ingredients could cause the
damage of skin microbiome (3). The cosmetics industry has focused on the production of
new cosmetic products that would affect the microbiome in order to improve the appearance
and condition of the skin, and the development of these products involves one of three basic
approaches: balancing or improvement of the skin microbiome, protection of skin
microbiome and activation of skin microbiome in order to achieve beneficial effects on the
skin. Data on the importance of microbiome and its metabolites in functioning of the skin
barrier drew the attention of cosmetic scientists to bacterial lysates, fermentation products
and metabolites to be used as cosmetic active ingredients that can achieve positive effects on
the skin in various types of cosmetics. The main challenges in the development of cosmetic
active ingredients and cosmetic products in the service of microbiome are their safety,
stability and efficacy investigation, and substation of microbiome claims for these products., Mikroflora ili mikrobiota je termin koji opisuje milione različitih mikroorganizama
(bakterije, kvasci, gljivice, virusi) koji žive na ljudskoj koži (1). Mikrobiom ljudske kože
postao je fokus u oblasti dermatologije i kozmetologije, a brojna istraživanja upućuju na to da
je održavanje njegovog balansa od suštinskog značaja za zdravu kožu i njen lep izgled.
Kozmetički proizvodi mogu uticati na oblikovanje specifičnih mikrobnih zajednica kože usled
promena njihovog hemijskog okruženja. Kozmetički proizvodi za čišćenje kože su efikasni u
održavanju higijene kože i zdravog biofilma, a posebna pažnja posvećuje se antibakterijskim
sapunima, koji mogu eliminisati i patogene i korisne mikroorganizme. Shodno tome,
smanjenje broja dobrih bakterija izazvano čestom upotrebom antibakterijskih sapuna
dugoročno može dovesti do negativnih efekata na zdravlje kože. U studiji u kojoj je procenjen
uticaj i efekti redovne upotrebe kozmetičkih proizvoda na mikrobiom kože pokazano je da
kozmetički proizvodi menjaju mikrobiom utičući na bakterijski diverzitet, dovodeći do
privremenih promena u količini i odnosu prisutnih bakterija, pri čemu su promene specifične
za vrstu kozmetičkog proizvoda, mesto primene i osobu (2). U drugoj studiji dobijeni
rezultati ukazuju na to da upotreba sintetičkih sastojaka iz kozmetičkih proizvoda može
dovesti do oštećenja mikrobioma kože (3). Kozmetička industrija usmerila se na proizvodnju
novih kozmetičkih proizvoda koji bi delovanjem na mikrobiom uticali na poboljšanje izgleda
i stanja kože, a razvoj ovih proizvoda podrazumeva jedan od tri osnovna pristupa: pokušaj
balansiranja ili poboljšanja mikrobioma kože, zaštitu mikrobioma kože i aktiviranje
mikrobioma u ostvarivanju različitih efekata na koži. Podaci o značaju mikrobioma i njegovih
metabolita u funkcionisanju kožne barijere usmerile su pažnju kozmetologa na mogućnost
upotrebe bakterijskih lizata, fermentacionih produkata i metabolita, kao kozmetički aktivnih
sastojaka koji mogu ostvariti pozitivne efekte na kožu u različitim vrstama kozmetičkih
proizvoda. Glavni izazov u razvoju kozmetički aktivnih supstanci ili kozmetičkih proizvoda u
službi mikrobioma je ispitivanje njihove bezbednosti, stabilnosti i efikasnosti, odnosno
potkrepljivanje tvrdnji vezanih za ove proizvode odgovarajućim dokazima.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Skin microbiome and cosmetic products, Mikrobiom kože i kozmetički proizvodi",
volume = "71",
number = "5 suplement",
pages = "S100-S101",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4674"
}

Todorović, J.,& Lukić, M.. (2021). Skin microbiome and cosmetic products. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 71(5 suplement), S100-S101.
https://hdl.handle.net/21.15107/rcub_farfar_4674

Todorović J, Lukić M. Skin microbiome and cosmetic products. in Arhiv za farmaciju. 2021;71(5 suplement):S100-S101.
https://hdl.handle.net/21.15107/rcub_farfar_4674 .

Todorović, Jelena, Lukić, Milica, "Skin microbiome and cosmetic products" in Arhiv za farmaciju, 71, no. 5 suplement (2021):S100-S101,
https://hdl.handle.net/21.15107/rcub_farfar_4674 .

TY  - JOUR
AU  - Lukić, Milica
AU  - Filipović, Mila
AU  - Pajić, Nevena
AU  - Lunter, Dominique
AU  - Božić, Dragana
AU  - Savić, Snežana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3912
AB  - Objective: The acidic skin pH is one of the regulating factors of skin barrier homeostasis. Topical products as extrinsic factors which influence skin pH could be used for acidification of the skin and consequent beneficial effect. To formulate stabile and safe topical emulsion product with low pH is on-going challenge and areas interesting to explore are related to the effect of acidic products on the skin pH together with development of protocols for these studies. Aim of our work was to investigate formulations of acidic topical products with glycolic acid (GA) stabilized with long chain alkyl polyglucoside emulsifier, in regard to the specific colloidal structure of the vehicle, together with effect of products with different concentration of acidic active on skin pH. Methods: Investigated formulations were basic vehicle and two creams with glycolic acid (concentration 2 and 10 wt%). Microstructure was investigated by polarization microscopy, Raman spectral imaging, thermal analysis and rheological measurements. Effects on the skin were assessed by measurement of biophysical skin parameters in vivo studies (5-hour, 24-hour and 7-days). In vitro screening of antimicrobial activity was performed against bacteria Staphylococcus epidermidis. Results: Polarization micrographs and Raman images have shown that GA does not disturb the specific colloidal structure. Together with rheological and thermal analysis obtained results have shown that GA in higher concentrations contributes to vehicles’ lamellar structure. In 5-hour study the mean values of skin pH ranged from 3.98-4.25 and 3.89-4.10 after application of products with smaller and higher GA concentration. GA samples lowered skin surface pH to 5 and less in 24-hour and 7-day study, with stronger effect of sample with more GA. Sample with 10% of GA had significant inhibitory effect on growth of S. epidermidis in 1:1 concentration. Conclusions: Investigated APG emulsifier could be used as a stabilizer for acidic topical products with GA which are characterized by satisfactory safety profile. Topical products induce acidification of the skin after short- and long-term application without barrier impairment or sign of irritation. Acidification of the skin depends on presence of ingredients which are proton donors and their concentrations.
PB  - Blackwell Publishing Ltd
T2  - International Journal of Cosmetic Science
T1  - Formulation of topical acidic products and acidification of the skin – Contribution of glycolic acid
DO  - 10.1111/ics.12707
ER  - 

@article{
author = "Lukić, Milica and Filipović, Mila and Pajić, Nevena and Lunter, Dominique and Božić, Dragana and Savić, Snežana",
year = "2021",
abstract = "Objective: The acidic skin pH is one of the regulating factors of skin barrier homeostasis. Topical products as extrinsic factors which influence skin pH could be used for acidification of the skin and consequent beneficial effect. To formulate stabile and safe topical emulsion product with low pH is on-going challenge and areas interesting to explore are related to the effect of acidic products on the skin pH together with development of protocols for these studies. Aim of our work was to investigate formulations of acidic topical products with glycolic acid (GA) stabilized with long chain alkyl polyglucoside emulsifier, in regard to the specific colloidal structure of the vehicle, together with effect of products with different concentration of acidic active on skin pH. Methods: Investigated formulations were basic vehicle and two creams with glycolic acid (concentration 2 and 10 wt%). Microstructure was investigated by polarization microscopy, Raman spectral imaging, thermal analysis and rheological measurements. Effects on the skin were assessed by measurement of biophysical skin parameters in vivo studies (5-hour, 24-hour and 7-days). In vitro screening of antimicrobial activity was performed against bacteria Staphylococcus epidermidis. Results: Polarization micrographs and Raman images have shown that GA does not disturb the specific colloidal structure. Together with rheological and thermal analysis obtained results have shown that GA in higher concentrations contributes to vehicles’ lamellar structure. In 5-hour study the mean values of skin pH ranged from 3.98-4.25 and 3.89-4.10 after application of products with smaller and higher GA concentration. GA samples lowered skin surface pH to 5 and less in 24-hour and 7-day study, with stronger effect of sample with more GA. Sample with 10% of GA had significant inhibitory effect on growth of S. epidermidis in 1:1 concentration. Conclusions: Investigated APG emulsifier could be used as a stabilizer for acidic topical products with GA which are characterized by satisfactory safety profile. Topical products induce acidification of the skin after short- and long-term application without barrier impairment or sign of irritation. Acidification of the skin depends on presence of ingredients which are proton donors and their concentrations.",
publisher = "Blackwell Publishing Ltd",
journal = "International Journal of Cosmetic Science",
title = "Formulation of topical acidic products and acidification of the skin – Contribution of glycolic acid",
doi = "10.1111/ics.12707"
}

Lukić, M., Filipović, M., Pajić, N., Lunter, D., Božić, D.,& Savić, S.. (2021). Formulation of topical acidic products and acidification of the skin – Contribution of glycolic acid. in International Journal of Cosmetic Science
Blackwell Publishing Ltd..
https://doi.org/10.1111/ics.12707

Lukić M, Filipović M, Pajić N, Lunter D, Božić D, Savić S. Formulation of topical acidic products and acidification of the skin – Contribution of glycolic acid. in International Journal of Cosmetic Science. 2021;.
doi:10.1111/ics.12707 .

Lukić, Milica, Filipović, Mila, Pajić, Nevena, Lunter, Dominique, Božić, Dragana, Savić, Snežana, "Formulation of topical acidic products and acidification of the skin – Contribution of glycolic acid" in International Journal of Cosmetic Science (2021),
https://doi.org/10.1111/ics.12707 . .

TY  - JOUR
AU  - Lukić, Milica
AU  - Pantelić, Ivana
AU  - Savić, Snežana
PY  - 2021
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112290407&doi=10.3390%2fcosmetics8030069&partnerID=40&md5=4998ada2cb26d6660cf9ee55c84e03c9
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3940
AB  - Acidic pH of the skin surface has been recognized as a regulating factor for the maintenance of the stratum corneum homeostasis and barrier permeability. The most important functions of acidic pH seem to be related to the keratinocyte differentiation process, the formation and function of epidermal lipids and the corneocyte lipid envelope, the maintenance of the skin microbiome and, consequently, skin disturbances and diseases. As acknowledged extrinsic factors that affect skin pH, topically applied products could contribute to skin health maintenance via skin pH value control. The obtained knowledge on skins’ pH could be used in the formulation of more effective topical products, which would add to the development of the so-called products ‘for skin health maintenance’. There is a high level of agreement that topical products should be acidified and possess pH in the range of 4 to 6. However, formulators, dermatologists and consumers would benefit from some more precise guidance concerning favorable products pH values and the selection of cosmetic ingredients which could be responsible for acidification, together with a more extensive understanding of the mechanisms underlaying the process of skin acidification by topical products.
PB  - MDPI AG
T2  - Cosmetics
T1  - Towards optimal ph of the skin and topical formulations: From the current state of the art to tailored products
VL  - 8
IS  - 3
DO  - 10.3390/cosmetics8030069
ER  - 

@article{
author = "Lukić, Milica and Pantelić, Ivana and Savić, Snežana",
year = "2021",
abstract = "Acidic pH of the skin surface has been recognized as a regulating factor for the maintenance of the stratum corneum homeostasis and barrier permeability. The most important functions of acidic pH seem to be related to the keratinocyte differentiation process, the formation and function of epidermal lipids and the corneocyte lipid envelope, the maintenance of the skin microbiome and, consequently, skin disturbances and diseases. As acknowledged extrinsic factors that affect skin pH, topically applied products could contribute to skin health maintenance via skin pH value control. The obtained knowledge on skins’ pH could be used in the formulation of more effective topical products, which would add to the development of the so-called products ‘for skin health maintenance’. There is a high level of agreement that topical products should be acidified and possess pH in the range of 4 to 6. However, formulators, dermatologists and consumers would benefit from some more precise guidance concerning favorable products pH values and the selection of cosmetic ingredients which could be responsible for acidification, together with a more extensive understanding of the mechanisms underlaying the process of skin acidification by topical products.",
publisher = "MDPI AG",
journal = "Cosmetics",
title = "Towards optimal ph of the skin and topical formulations: From the current state of the art to tailored products",
volume = "8",
number = "3",
doi = "10.3390/cosmetics8030069"
}

Lukić, M., Pantelić, I.,& Savić, S.. (2021). Towards optimal ph of the skin and topical formulations: From the current state of the art to tailored products. in Cosmetics
MDPI AG., 8(3).
https://doi.org/10.3390/cosmetics8030069

Lukić M, Pantelić I, Savić S. Towards optimal ph of the skin and topical formulations: From the current state of the art to tailored products. in Cosmetics. 2021;8(3).
doi:10.3390/cosmetics8030069 .

Lukić, Milica, Pantelić, Ivana, Savić, Snežana, "Towards optimal ph of the skin and topical formulations: From the current state of the art to tailored products" in Cosmetics, 8, no. 3 (2021),
https://doi.org/10.3390/cosmetics8030069 . .

TY  - JOUR
AU  - Pantelić, Ivana
AU  - Lukić, Milica
AU  - Gojgić-Cvijović, Gordana
AU  - Jakovljević, Dragica
AU  - Nikolić, Ines
AU  - Lunter, Dominique Jasmin
AU  - Daniels, Rolf
AU  - Savić, Snežana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3500
AB  - Ongoing demand in sustainable and biocompatible drug dosage forms is reflected in the search for novel pharmaceutical excipients with equal properties. A group of microbial exopolysaccharides offers a variety of biopolymers with many alleged uses and effects. This study aims to assess applicative properties of levan obtained from Bacillus licheniformis NS032, focusing on its potential co-stabilizing and drug release-controlling functions in pertaining emulsion systems. Despite its high molecular weight and partial existence in globular nanometric structures (180-190 nm), levan was successfully incorporated into both tested colloidal systems: those stabilized with synthetic/anionic or natural-origin/non-ionic emulsifiers. In the tested levan concentrations range (0.2-3.0% w/w) the monitored flow and thermal parameters failed to show linear concentration dependence, which prompted us to revisit certain colloidal fundamentals of this biopolymer. Being a part of the external phase of the investigated emulsion systems, levan contributed to formation of a matrix-like environment, offering additional stabilization of the microstructure and rheology modifying properties (hysteresis loop elevation as high as 4167±98 to 20792±3166 Pa•s−1), especially in case of the samples where lamellar liquid crystalline formation occurred. Apart from its good water solubility and considerable conformational flexibility, the investigated homofructan easily saturated the external phase of the samples stabilized with a conventional anionic emulsifier, leading to similar properties of 0.2% and 3.0% levan-containing samples. After closer consideration of thermal and release behavior, this was considered as a favorable property for a novel excipient, offering tailored formulation characteristics even with lower levan concentrations, consequently not compromising the potential cost of the final drug dosage form.
PB  - Elsevier
T2  - European Journal of Pharmaceutical Sciences
T1  - Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application
VL  - 142
DO  - 10.1016/j.ejps.2019.105109
ER  - 

@article{
author = "Pantelić, Ivana and Lukić, Milica and Gojgić-Cvijović, Gordana and Jakovljević, Dragica and Nikolić, Ines and Lunter, Dominique Jasmin and Daniels, Rolf and Savić, Snežana",
year = "2020",
abstract = "Ongoing demand in sustainable and biocompatible drug dosage forms is reflected in the search for novel pharmaceutical excipients with equal properties. A group of microbial exopolysaccharides offers a variety of biopolymers with many alleged uses and effects. This study aims to assess applicative properties of levan obtained from Bacillus licheniformis NS032, focusing on its potential co-stabilizing and drug release-controlling functions in pertaining emulsion systems. Despite its high molecular weight and partial existence in globular nanometric structures (180-190 nm), levan was successfully incorporated into both tested colloidal systems: those stabilized with synthetic/anionic or natural-origin/non-ionic emulsifiers. In the tested levan concentrations range (0.2-3.0% w/w) the monitored flow and thermal parameters failed to show linear concentration dependence, which prompted us to revisit certain colloidal fundamentals of this biopolymer. Being a part of the external phase of the investigated emulsion systems, levan contributed to formation of a matrix-like environment, offering additional stabilization of the microstructure and rheology modifying properties (hysteresis loop elevation as high as 4167±98 to 20792±3166 Pa•s−1), especially in case of the samples where lamellar liquid crystalline formation occurred. Apart from its good water solubility and considerable conformational flexibility, the investigated homofructan easily saturated the external phase of the samples stabilized with a conventional anionic emulsifier, leading to similar properties of 0.2% and 3.0% levan-containing samples. After closer consideration of thermal and release behavior, this was considered as a favorable property for a novel excipient, offering tailored formulation characteristics even with lower levan concentrations, consequently not compromising the potential cost of the final drug dosage form.",
publisher = "Elsevier",
journal = "European Journal of Pharmaceutical Sciences",
title = "Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application",
volume = "142",
doi = "10.1016/j.ejps.2019.105109"
}

Pantelić, I., Lukić, M., Gojgić-Cvijović, G., Jakovljević, D., Nikolić, I., Lunter, D. J., Daniels, R.,& Savić, S.. (2020). Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application. in European Journal of Pharmaceutical Sciences
Elsevier., 142.
https://doi.org/10.1016/j.ejps.2019.105109

Pantelić I, Lukić M, Gojgić-Cvijović G, Jakovljević D, Nikolić I, Lunter DJ, Daniels R, Savić S. Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application. in European Journal of Pharmaceutical Sciences. 2020;142.
doi:10.1016/j.ejps.2019.105109 .

Pantelić, Ivana, Lukić, Milica, Gojgić-Cvijović, Gordana, Jakovljević, Dragica, Nikolić, Ines, Lunter, Dominique Jasmin, Daniels, Rolf, Savić, Snežana, "Bacillus licheniformis levan as a functional biopolymer in topical drug dosage forms: From basic colloidal considerations to actual pharmaceutical application" in European Journal of Pharmaceutical Sciences, 142 (2020),
https://doi.org/10.1016/j.ejps.2019.105109 . .

TY  - JOUR
AU  - Lukić, Milica
AU  - Pantelić, Ivana
AU  - Savić, Snežana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3725
AB  - Emollients are acknowledged as a part of standard care in therapeutic and prevention protocols as well as a part of everyday skin care routine. When it comes to making a final decision between two emollient products, the ingredient list, that is, the formulation composition could be the determining factor. In such cases the consumer, and some healthcare providers, believe that products with the same qualitative composition (ingredient list) must have the same efficacy. In this study, we have investigated the skin hydration performance of two emollient preparations (DBG and MBG), which appear to contain the same ingredients, and hence, could be considered interchangeable in everyday practice. Our studies showed that the effects of DBG were overall superior to the ones attributed to MBG at each investigated time point (1, 2, 4, and 24 h post application) when tested on normal and dry skin. Consequently, it is shown that two apparently qualitatively identical products do not necessarily provide matching efficacy.
PB  - Blackwell Publishing Inc
T2  - Dermatologic Therapy
T1  - A comparison of Myribase and Doublebase gel: Does qualitative similarity of emollient products imply their direct interchangeability in everyday practice?
VL  - 33
IS  - 6
DO  - 10.1111/dth.14020
ER  - 

@article{
author = "Lukić, Milica and Pantelić, Ivana and Savić, Snežana",
year = "2020",
abstract = "Emollients are acknowledged as a part of standard care in therapeutic and prevention protocols as well as a part of everyday skin care routine. When it comes to making a final decision between two emollient products, the ingredient list, that is, the formulation composition could be the determining factor. In such cases the consumer, and some healthcare providers, believe that products with the same qualitative composition (ingredient list) must have the same efficacy. In this study, we have investigated the skin hydration performance of two emollient preparations (DBG and MBG), which appear to contain the same ingredients, and hence, could be considered interchangeable in everyday practice. Our studies showed that the effects of DBG were overall superior to the ones attributed to MBG at each investigated time point (1, 2, 4, and 24 h post application) when tested on normal and dry skin. Consequently, it is shown that two apparently qualitatively identical products do not necessarily provide matching efficacy.",
publisher = "Blackwell Publishing Inc",
journal = "Dermatologic Therapy",
title = "A comparison of Myribase and Doublebase gel: Does qualitative similarity of emollient products imply their direct interchangeability in everyday practice?",
volume = "33",
number = "6",
doi = "10.1111/dth.14020"
}

Lukić, M., Pantelić, I.,& Savić, S.. (2020). A comparison of Myribase and Doublebase gel: Does qualitative similarity of emollient products imply their direct interchangeability in everyday practice?. in Dermatologic Therapy
Blackwell Publishing Inc., 33(6).
https://doi.org/10.1111/dth.14020

Lukić M, Pantelić I, Savić S. A comparison of Myribase and Doublebase gel: Does qualitative similarity of emollient products imply their direct interchangeability in everyday practice?. in Dermatologic Therapy. 2020;33(6).
doi:10.1111/dth.14020 .

Lukić, Milica, Pantelić, Ivana, Savić, Snežana, "A comparison of Myribase and Doublebase gel: Does qualitative similarity of emollient products imply their direct interchangeability in everyday practice?" in Dermatologic Therapy, 33, no. 6 (2020),
https://doi.org/10.1111/dth.14020 . .

TY  - CONF
AU  - Lukić, Milica
AU  - Pantelić, Ivana
AU  - Savić, Snežana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3367
PB  - Wiley, Hoboken
C3  - Journal of the European Academy of Dermatology and Venereology
T1  - Novel anti-inflammatory emollient gel: assessment of efficacy in SLS provoked/irritated skin
VL  - 33
IS  - Supplement 3
SP  - 78
EP  - 78
DO  - 10.1111/jdv.15514
ER  - 

@conference{
author = "Lukić, Milica and Pantelić, Ivana and Savić, Snežana",
year = "2019",
publisher = "Wiley, Hoboken",
journal = "Journal of the European Academy of Dermatology and Venereology",
title = "Novel anti-inflammatory emollient gel: assessment of efficacy in SLS provoked/irritated skin",
volume = "33",
number = "Supplement 3",
pages = "78-78",
doi = "10.1111/jdv.15514"
}

Lukić, M., Pantelić, I.,& Savić, S.. (2019). Novel anti-inflammatory emollient gel: assessment of efficacy in SLS provoked/irritated skin. in Journal of the European Academy of Dermatology and Venereology
Wiley, Hoboken., 33(Supplement 3), 78-78.
https://doi.org/10.1111/jdv.15514

Lukić M, Pantelić I, Savić S. Novel anti-inflammatory emollient gel: assessment of efficacy in SLS provoked/irritated skin. in Journal of the European Academy of Dermatology and Venereology. 2019;33(Supplement 3):78-78.
doi:10.1111/jdv.15514 .

Lukić, Milica, Pantelić, Ivana, Savić, Snežana, "Novel anti-inflammatory emollient gel: assessment of efficacy in SLS provoked/irritated skin" in Journal of the European Academy of Dermatology and Venereology, 33, no. Supplement 3 (2019):78-78,
https://doi.org/10.1111/jdv.15514 . .

TY  - JOUR
AU  - Filipović, Mila
AU  - Lukić, Milica
AU  - Savić, Snežana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3489
AB  - Promene na koži i njenim adneksima, do kojih dolazi tokom trudnoće, često su uzrok
nezadovoljstva i razlog zbog koga trudnice i dojilje svakodnevno koriste brojne kozmetičke
proizvode i pokazuju interesovanje za različite estetske procedure. Premda bezbednost
kozmetičkih proizvoda mora biti potvrđena pre pojavljivanja na tržištu, činjenica je da se
njihova bezbednost, kao ni bezbednost estetskih procedura, ne procenjuje na trudnicama i
dojiljama. Izbor odgovarajućih proizvoda dodatno komplikuje odsustvo zvanične liste sastojaka
koje bi trebalo uzeti u razmatranje tokom trudnoće i laktacije, poput poznatih ili potencijalnih
endokrinih disruptora/ometača ili jedinjenja (potencijalno) toksičnih po reprodukciju. Dodatno,
ne postoje zvanične preporuke regulatornih tela i udruženja zdravstvenih profesionalaca, koje bi
olakšale izbor kozmetičkih proizvoda koje trudnice i dojilje mogu da koriste, ali i otklonile
eventualni strah od izlaganja ploda/bebe nebezbednim supstancama.
U ovom radu dat je pregled podataka vezanih za bezbednost određenih kozmetičkih
sastojaka, kao i različitih kategorija kozmetičkih proizvoda i neinvazivnih estetskih procedura,
uz pokušaj konsolidovanja podataka u konkretne preporuke vezane za izbor i njihovu primenu
tokom trudnoće i laktacije.
AB  - Changes of the skin and skin appendages, which occur during pregnancy, are often the
cause of discontentment and the reason why pregnant and breastfeeding women use numerous
cosmetic products on the daily basis and show the interest for the different aesthetic procedures.
Although safety of cosmetic products must be confirmed before the product is placed on the
market, the fact is that their safety, as well as the safety of aesthetic procedures, is not estimated
on pregnant or breastfeeding women. The selection of an appropriate product is further
complicated by the absence of the list of allowed raw materials which should be considered
during pregnancy and lactation, especially for substances that are known or potential endocrine
disruptors or substances which are (potentially) toxic for the reproduction. Additionally, there
are no official recommendations issued by the regulatory bodies or any healthcare associations,
which would facilitate the selection of cosmetic products during pregnancy and breastfeeding
and reduce the possible fear regarding the exposure of fetus/baby to unsafe ingredients.
The paper provides an overview of the safety data of the specified cosmetic ingredients,
different categories of cosmetic products and non-invasive aesthetic procedures, with an attempt
to consolidate those data into the specific recommendations regarding selection and their usage
during pregnancy and lactation.
PB  - Beograd : Savez farmaceutskih udruženja Srbije
T2  - Arhiv za farmaciju
T1  - Cosmetic products and non-invasive aesthetic procedures: safety of usage and recommendations regarding selection during pregnancy and lactation / Kozmetički proizvodi i neinvazivne estetske procedure: bezbednost primene i preporuke za izbor tokom trudnoće i laktacije
VL  - 69
IS  - 3
SP  - 199
EP  - 212
DO  - 10.5937/arhfarm1903199F
ER  - 

@article{
author = "Filipović, Mila and Lukić, Milica and Savić, Snežana",
year = "2019",
abstract = "Promene na koži i njenim adneksima, do kojih dolazi tokom trudnoće, često su uzrok
nezadovoljstva i razlog zbog koga trudnice i dojilje svakodnevno koriste brojne kozmetičke
proizvode i pokazuju interesovanje za različite estetske procedure. Premda bezbednost
kozmetičkih proizvoda mora biti potvrđena pre pojavljivanja na tržištu, činjenica je da se
njihova bezbednost, kao ni bezbednost estetskih procedura, ne procenjuje na trudnicama i
dojiljama. Izbor odgovarajućih proizvoda dodatno komplikuje odsustvo zvanične liste sastojaka
koje bi trebalo uzeti u razmatranje tokom trudnoće i laktacije, poput poznatih ili potencijalnih
endokrinih disruptora/ometača ili jedinjenja (potencijalno) toksičnih po reprodukciju. Dodatno,
ne postoje zvanične preporuke regulatornih tela i udruženja zdravstvenih profesionalaca, koje bi
olakšale izbor kozmetičkih proizvoda koje trudnice i dojilje mogu da koriste, ali i otklonile
eventualni strah od izlaganja ploda/bebe nebezbednim supstancama.
U ovom radu dat je pregled podataka vezanih za bezbednost određenih kozmetičkih
sastojaka, kao i različitih kategorija kozmetičkih proizvoda i neinvazivnih estetskih procedura,
uz pokušaj konsolidovanja podataka u konkretne preporuke vezane za izbor i njihovu primenu
tokom trudnoće i laktacije., Changes of the skin and skin appendages, which occur during pregnancy, are often the
cause of discontentment and the reason why pregnant and breastfeeding women use numerous
cosmetic products on the daily basis and show the interest for the different aesthetic procedures.
Although safety of cosmetic products must be confirmed before the product is placed on the
market, the fact is that their safety, as well as the safety of aesthetic procedures, is not estimated
on pregnant or breastfeeding women. The selection of an appropriate product is further
complicated by the absence of the list of allowed raw materials which should be considered
during pregnancy and lactation, especially for substances that are known or potential endocrine
disruptors or substances which are (potentially) toxic for the reproduction. Additionally, there
are no official recommendations issued by the regulatory bodies or any healthcare associations,
which would facilitate the selection of cosmetic products during pregnancy and breastfeeding
and reduce the possible fear regarding the exposure of fetus/baby to unsafe ingredients.
The paper provides an overview of the safety data of the specified cosmetic ingredients,
different categories of cosmetic products and non-invasive aesthetic procedures, with an attempt
to consolidate those data into the specific recommendations regarding selection and their usage
during pregnancy and lactation.",
publisher = "Beograd : Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za farmaciju",
title = "Cosmetic products and non-invasive aesthetic procedures: safety of usage and recommendations regarding selection during pregnancy and lactation / Kozmetički proizvodi i neinvazivne estetske procedure: bezbednost primene i preporuke za izbor tokom trudnoće i laktacije",
volume = "69",
number = "3",
pages = "199-212",
doi = "10.5937/arhfarm1903199F"
}

Filipović, M., Lukić, M.,& Savić, S.. (2019). Cosmetic products and non-invasive aesthetic procedures: safety of usage and recommendations regarding selection during pregnancy and lactation / Kozmetički proizvodi i neinvazivne estetske procedure: bezbednost primene i preporuke za izbor tokom trudnoće i laktacije. in Arhiv za farmaciju
Beograd : Savez farmaceutskih udruženja Srbije., 69(3), 199-212.
https://doi.org/10.5937/arhfarm1903199F

Filipović M, Lukić M, Savić S. Cosmetic products and non-invasive aesthetic procedures: safety of usage and recommendations regarding selection during pregnancy and lactation / Kozmetički proizvodi i neinvazivne estetske procedure: bezbednost primene i preporuke za izbor tokom trudnoće i laktacije. in Arhiv za farmaciju. 2019;69(3):199-212.
doi:10.5937/arhfarm1903199F .

Filipović, Mila, Lukić, Milica, Savić, Snežana, "Cosmetic products and non-invasive aesthetic procedures: safety of usage and recommendations regarding selection during pregnancy and lactation / Kozmetički proizvodi i neinvazivne estetske procedure: bezbednost primene i preporuke za izbor tokom trudnoće i laktacije" in Arhiv za farmaciju, 69, no. 3 (2019):199-212,
https://doi.org/10.5937/arhfarm1903199F . .

TY  - JOUR
AU  - Tasić-Kostov, Marija
AU  - Lukić, Milica
AU  - Savić, Snežana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3290
AB  - Background/Objectives: Stratum corneum acidification is a newer strategy in management of inflammatory dermatoses; acidifying emollients are normally used for that purpose. However, a decrease in pH of the skin is commonly connected to an increase in irritation. The aim of this study was to investigate whether lactobionic acid (LA), cosmeceutical active and "superacid" belonging to the class of alpha-hydroxy acids (AHAs), could decrease pH of skin surface without irritation. Methods: Safety profile of emulsion based on alkyl polyglucosides (APGs) sugar emulsifiers with 10% LA was evaluated in vitro (acute skin irritation test using cytotoxicity assay), and in vivo in safety study employing measurements of the relevant biophysical human skin parameters upon cessation of 24 hours occlusive treatment: transepidermal water loss (TEWL), stratum corneum hydration (SCH), and skin erythema index (EI). The effect on the pH of human skin surface was investigated by pH measurements prior and 1 hour after application of the emulsion with 10% LA. Results: The pH of the skin was significantly reduced after application of LA-containing emulsion. The results for in vitro skin irritation potential assessment were in line with the in vivo safety study, indicating a satisfactory safety profile of both APG-based emulsion vehicle per se and emulsion with 10% LA. Conclusion: Lactobionic acid (10%) in emulsion based on APGs reduces skin surface pH without irritation and skin barrier impairment; it could be proposed as an alternative to low-molecular AHAs in acidifying emollients.
PB  - Blackwell Publishing Ltd
T2  - Journal of Cosmetic Dermatology
T1  - A 10% Lactobionic acid-containing moisturizer reduces skin surface pH without irritation—An in vivo/in vitro study
DO  - 10.1111/jocd.12908
ER  - 

@article{
author = "Tasić-Kostov, Marija and Lukić, Milica and Savić, Snežana",
year = "2019",
abstract = "Background/Objectives: Stratum corneum acidification is a newer strategy in management of inflammatory dermatoses; acidifying emollients are normally used for that purpose. However, a decrease in pH of the skin is commonly connected to an increase in irritation. The aim of this study was to investigate whether lactobionic acid (LA), cosmeceutical active and "superacid" belonging to the class of alpha-hydroxy acids (AHAs), could decrease pH of skin surface without irritation. Methods: Safety profile of emulsion based on alkyl polyglucosides (APGs) sugar emulsifiers with 10% LA was evaluated in vitro (acute skin irritation test using cytotoxicity assay), and in vivo in safety study employing measurements of the relevant biophysical human skin parameters upon cessation of 24 hours occlusive treatment: transepidermal water loss (TEWL), stratum corneum hydration (SCH), and skin erythema index (EI). The effect on the pH of human skin surface was investigated by pH measurements prior and 1 hour after application of the emulsion with 10% LA. Results: The pH of the skin was significantly reduced after application of LA-containing emulsion. The results for in vitro skin irritation potential assessment were in line with the in vivo safety study, indicating a satisfactory safety profile of both APG-based emulsion vehicle per se and emulsion with 10% LA. Conclusion: Lactobionic acid (10%) in emulsion based on APGs reduces skin surface pH without irritation and skin barrier impairment; it could be proposed as an alternative to low-molecular AHAs in acidifying emollients.",
publisher = "Blackwell Publishing Ltd",
journal = "Journal of Cosmetic Dermatology",
title = "A 10% Lactobionic acid-containing moisturizer reduces skin surface pH without irritation—An in vivo/in vitro study",
doi = "10.1111/jocd.12908"
}

Tasić-Kostov, M., Lukić, M.,& Savić, S.. (2019). A 10% Lactobionic acid-containing moisturizer reduces skin surface pH without irritation—An in vivo/in vitro study. in Journal of Cosmetic Dermatology
Blackwell Publishing Ltd..
https://doi.org/10.1111/jocd.12908

Tasić-Kostov M, Lukić M, Savić S. A 10% Lactobionic acid-containing moisturizer reduces skin surface pH without irritation—An in vivo/in vitro study. in Journal of Cosmetic Dermatology. 2019;.
doi:10.1111/jocd.12908 .

Tasić-Kostov, Marija, Lukić, Milica, Savić, Snežana, "A 10% Lactobionic acid-containing moisturizer reduces skin surface pH without irritation—An in vivo/in vitro study" in Journal of Cosmetic Dermatology (2019),
https://doi.org/10.1111/jocd.12908 . .

TY  - JOUR
AU  - Pantelić, Ivana
AU  - Ilić, Tanja
AU  - Marković, Bojan
AU  - Savić, Sanela
AU  - Lukić, Milica
AU  - Savić, Snežana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3151
AB  - After decades long absence of an official consensus on the most appropriate evaluation method for in vitro skin performance of topical semisolid drugs, United States Pharmacopoeia (USP 39) finally suggested three types of testing equipment; however, all these provide data on drug release using inert synthetic membranes. Considering the need for a readily available membrane that would be more structurally similar to human skin, this paper provides a detailed protocol of a method for drug permeation assessment that uses heat-separated porcine ear epidermis and modified Franz diffusion cells. Phases that were shown to be critical for variability of the results are identified (e.g., membrane preparation), and process parameters optimized. Applicability of the method was tested on four cream samples loaded with aceclofenac as a model drug. Sample compositions were designed in such a way to provide, large "variations (variation of the main stabilizer: natural-origin versus synthetic emulsifier) and relatively, minor" variations (co-solvent variation: none/isopropanol/glycerol). The developed protocol is a straightforward and reliable in vitro test for the evaluation of rate and extent of drug delivery into/through the skin. Moreover, this protocol may be routinely applied even in averagely equipped laboratories during formulation development or preliminary bioequivalence assessment of generic topical semisolids.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - A stepwise protocol for drug permeation assessment that combines heat-separated porcine ear epidermis and vertical diffusion cells
VL  - 72
IS  - 1
SP  - 47
EP  - 53
DO  - 10.2298/HEMIND170726019P
ER  - 

@article{
author = "Pantelić, Ivana and Ilić, Tanja and Marković, Bojan and Savić, Sanela and Lukić, Milica and Savić, Snežana",
year = "2018",
abstract = "After decades long absence of an official consensus on the most appropriate evaluation method for in vitro skin performance of topical semisolid drugs, United States Pharmacopoeia (USP 39) finally suggested three types of testing equipment; however, all these provide data on drug release using inert synthetic membranes. Considering the need for a readily available membrane that would be more structurally similar to human skin, this paper provides a detailed protocol of a method for drug permeation assessment that uses heat-separated porcine ear epidermis and modified Franz diffusion cells. Phases that were shown to be critical for variability of the results are identified (e.g., membrane preparation), and process parameters optimized. Applicability of the method was tested on four cream samples loaded with aceclofenac as a model drug. Sample compositions were designed in such a way to provide, large "variations (variation of the main stabilizer: natural-origin versus synthetic emulsifier) and relatively, minor" variations (co-solvent variation: none/isopropanol/glycerol). The developed protocol is a straightforward and reliable in vitro test for the evaluation of rate and extent of drug delivery into/through the skin. Moreover, this protocol may be routinely applied even in averagely equipped laboratories during formulation development or preliminary bioequivalence assessment of generic topical semisolids.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "A stepwise protocol for drug permeation assessment that combines heat-separated porcine ear epidermis and vertical diffusion cells",
volume = "72",
number = "1",
pages = "47-53",
doi = "10.2298/HEMIND170726019P"
}

Pantelić, I., Ilić, T., Marković, B., Savić, S., Lukić, M.,& Savić, S.. (2018). A stepwise protocol for drug permeation assessment that combines heat-separated porcine ear epidermis and vertical diffusion cells. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 72(1), 47-53.
https://doi.org/10.2298/HEMIND170726019P

Pantelić I, Ilić T, Marković B, Savić S, Lukić M, Savić S. A stepwise protocol for drug permeation assessment that combines heat-separated porcine ear epidermis and vertical diffusion cells. in Hemijska industrija. 2018;72(1):47-53.
doi:10.2298/HEMIND170726019P .

Pantelić, Ivana, Ilić, Tanja, Marković, Bojan, Savić, Sanela, Lukić, Milica, Savić, Snežana, "A stepwise protocol for drug permeation assessment that combines heat-separated porcine ear epidermis and vertical diffusion cells" in Hemijska industrija, 72, no. 1 (2018):47-53,
https://doi.org/10.2298/HEMIND170726019P . .

TY  - JOUR
AU  - Zhang, Z.
AU  - Lukić, Milica
AU  - Savić, Snežana
AU  - Lunter, Dominique
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3043
AB  - Objective The aim of the study was to develop formulations to deliver physiological lipids into skin in an attempt to repair defective barrier function. MethodsResultsPhysiological cholesterol and linoleic acid were incorporated into basic cream and non-ionic cream to prepare skin repair formulations. Homogeneity and storage stability of the developed creams were examined by polarized light microscopy. Ex vivo evaluation was conducted using lipid-deficient skin samples and confocal Raman microspectroscopy. A 7-day invivo study was performed on volunteers to study the repairing efficacy. Homogeneous texture was seen in the prepared skin repair formulations. The application of the creams led to substantially increased lipid levels compared to the reference in the lipid-deficient skin in exvivo study. Twice-a-day application of the skin repair creams provided a reinforcement of the skin barrier as transepidermal water loss (TEWL) was significantly decreased. ConclusionResumeThe skin repair creams showed excellent efficacy in skin recovery. They have great potentials for treating impaired skin barrier associated with depletion of lipids in stratum corneum. ObjectifMethodesl'objectif de l'etude etait de developper des formulations pour delivrer des lipides physiologiques dans la peau dans le but de reparer une fonction barriere defectueuse. du cholesterol et de l'acide linoleique physiologiques ont ete incorpores dans une creme basique et une creme non-ionique afin de realiser des formulations pour la reparation de la peau. L'homogeneite et la stabilite au cours de la conservation des cremes developpees ont ete examinees par microscopie en lumiere polarisee. Une evaluation exvivo a ete realisee en utilisant des echantillons de peau delipidee et la microspectroscopie confocale Raman. Une etude invivo de 7jours a ete realisee sur des volontaires pour etudier l'efficacite de la reparation. ResultatsConclusionune texture homogene a ete observee dans les formulations preparees pour reparation cutanee. L'application des cremes a conduit a une augmentation substantielle des taux de lipides par rapport au temoin dans l'etude exvivo sur la peau delipidee. Une application deux fois par jour des cremes reparatrices cutanees a permis de renforcer la barriere cutanee, car la perte d'eau transepidermique (transepidermal water loss, TEWL) a ete significativement diminuee. les cremes reparatrices cutanees ont montre une excellente efficacite au niveau de la regeneration de la peau. Elles possedent des potentiels eleves pour traiter une alteration de la barriere cutanee associee a un appauvrissement en lipides de la couche cornee.
PB  - Wiley, Hoboken
T2  - International Journal of Cosmetic Science
T1  - Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin
VL  - 40
IS  - 5
SP  - 494
EP  - 501
DO  - 10.1111/ics.12491
ER  - 

@article{
author = "Zhang, Z. and Lukić, Milica and Savić, Snežana and Lunter, Dominique",
year = "2018",
abstract = "Objective The aim of the study was to develop formulations to deliver physiological lipids into skin in an attempt to repair defective barrier function. MethodsResultsPhysiological cholesterol and linoleic acid were incorporated into basic cream and non-ionic cream to prepare skin repair formulations. Homogeneity and storage stability of the developed creams were examined by polarized light microscopy. Ex vivo evaluation was conducted using lipid-deficient skin samples and confocal Raman microspectroscopy. A 7-day invivo study was performed on volunteers to study the repairing efficacy. Homogeneous texture was seen in the prepared skin repair formulations. The application of the creams led to substantially increased lipid levels compared to the reference in the lipid-deficient skin in exvivo study. Twice-a-day application of the skin repair creams provided a reinforcement of the skin barrier as transepidermal water loss (TEWL) was significantly decreased. ConclusionResumeThe skin repair creams showed excellent efficacy in skin recovery. They have great potentials for treating impaired skin barrier associated with depletion of lipids in stratum corneum. ObjectifMethodesl'objectif de l'etude etait de developper des formulations pour delivrer des lipides physiologiques dans la peau dans le but de reparer une fonction barriere defectueuse. du cholesterol et de l'acide linoleique physiologiques ont ete incorpores dans une creme basique et une creme non-ionique afin de realiser des formulations pour la reparation de la peau. L'homogeneite et la stabilite au cours de la conservation des cremes developpees ont ete examinees par microscopie en lumiere polarisee. Une evaluation exvivo a ete realisee en utilisant des echantillons de peau delipidee et la microspectroscopie confocale Raman. Une etude invivo de 7jours a ete realisee sur des volontaires pour etudier l'efficacite de la reparation. ResultatsConclusionune texture homogene a ete observee dans les formulations preparees pour reparation cutanee. L'application des cremes a conduit a une augmentation substantielle des taux de lipides par rapport au temoin dans l'etude exvivo sur la peau delipidee. Une application deux fois par jour des cremes reparatrices cutanees a permis de renforcer la barriere cutanee, car la perte d'eau transepidermique (transepidermal water loss, TEWL) a ete significativement diminuee. les cremes reparatrices cutanees ont montre une excellente efficacite au niveau de la regeneration de la peau. Elles possedent des potentiels eleves pour traiter une alteration de la barriere cutanee associee a un appauvrissement en lipides de la couche cornee.",
publisher = "Wiley, Hoboken",
journal = "International Journal of Cosmetic Science",
title = "Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin",
volume = "40",
number = "5",
pages = "494-501",
doi = "10.1111/ics.12491"
}

Zhang, Z., Lukić, M., Savić, S.,& Lunter, D.. (2018). Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin. in International Journal of Cosmetic Science
Wiley, Hoboken., 40(5), 494-501.
https://doi.org/10.1111/ics.12491

Zhang Z, Lukić M, Savić S, Lunter D. Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin. in International Journal of Cosmetic Science. 2018;40(5):494-501.
doi:10.1111/ics.12491 .

Zhang, Z., Lukić, Milica, Savić, Snežana, Lunter, Dominique, "Reinforcement of barrier function - skin repair formulations to deliver physiological lipids into skin" in International Journal of Cosmetic Science, 40, no. 5 (2018):494-501,
https://doi.org/10.1111/ics.12491 . .

TY  - JOUR
AU  - Lukić, Milica
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3118
AB  - Preservatives, colourants and UV filters are important groups of cosmetic product ingredients and without them many of these products could not exist. Regarding the fact that these substances are in the focus of consumers' interest, as substances which are toxic, in this paper their safety aspects are more precisely defined and explained. These substances are of special importance when safety of cosmetics is discussed and regulatory bodies work on the constant improvement of their safety use. The use of those substances in EU is regulated under Regulation EC No 1223/2009 for cosmetic products and Annexes listed in the Regulation. In this work information related to safety of preservatives, colourants and UV filters from the EU regulation in force, mentioned Regulation EC No 1223/2009, with the consideration of other important regulations and latest scientific literature on this topic are presented.
AB  - Konzervansi, sredstva za bojenje i UV filteri su važne grupe sastojaka kozmetičkih proizvoda, bez kojih se ovi proizvodi danas ne mogu zamisliti. Zbog činjenice da su ovi sastojci u žiži interesovanja korisnika, kao supstance koje imaju potencijal da izazovu štetan efekat, u ovom radu su bliže definisani i objašnjeni aspekti bezbedne primene sastojaka kozmetičkih proizvoda iz ovih grupa. Ovi sastojci imaju poseban značaj kada se govori o bezbednosti i regulatorna tela konstantno rade na unapređenju zakonskih propisa u cilju njihove bezbedne primene. Upotreba navedenih sastojaka u kozmetičkim proizvodima je na nivou EU zakonski regulisana zahtevima koji se navode u Uredbi EC 1223/2009 o kozmetičkim proizvodima i njenim Prilozima. U radu su prikazani podaci o bezbednosti konzervanasa, sredstava za bojenje i UV filtera iz važećeg zakonskog propisa EU, pomenute Uredbe, uz osvrta na druge značajne propise i savremenu naučnu literaturu koja se bavi ovim pitanjima.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Preservatives, colorants and UV filters in cosmetic products: Safety aspects
T1  - Konzervansi, sredstva za bojenje i UV filteri u kozmetičkim proizvodima - aspekti bezbedne primene
VL  - 68
IS  - 5
SP  - 934
EP  - 948
DO  - 10.5937/ArhFarm1805934L
ER  - 

@article{
author = "Lukić, Milica",
year = "2018",
abstract = "Preservatives, colourants and UV filters are important groups of cosmetic product ingredients and without them many of these products could not exist. Regarding the fact that these substances are in the focus of consumers' interest, as substances which are toxic, in this paper their safety aspects are more precisely defined and explained. These substances are of special importance when safety of cosmetics is discussed and regulatory bodies work on the constant improvement of their safety use. The use of those substances in EU is regulated under Regulation EC No 1223/2009 for cosmetic products and Annexes listed in the Regulation. In this work information related to safety of preservatives, colourants and UV filters from the EU regulation in force, mentioned Regulation EC No 1223/2009, with the consideration of other important regulations and latest scientific literature on this topic are presented., Konzervansi, sredstva za bojenje i UV filteri su važne grupe sastojaka kozmetičkih proizvoda, bez kojih se ovi proizvodi danas ne mogu zamisliti. Zbog činjenice da su ovi sastojci u žiži interesovanja korisnika, kao supstance koje imaju potencijal da izazovu štetan efekat, u ovom radu su bliže definisani i objašnjeni aspekti bezbedne primene sastojaka kozmetičkih proizvoda iz ovih grupa. Ovi sastojci imaju poseban značaj kada se govori o bezbednosti i regulatorna tela konstantno rade na unapređenju zakonskih propisa u cilju njihove bezbedne primene. Upotreba navedenih sastojaka u kozmetičkim proizvodima je na nivou EU zakonski regulisana zahtevima koji se navode u Uredbi EC 1223/2009 o kozmetičkim proizvodima i njenim Prilozima. U radu su prikazani podaci o bezbednosti konzervanasa, sredstava za bojenje i UV filtera iz važećeg zakonskog propisa EU, pomenute Uredbe, uz osvrta na druge značajne propise i savremenu naučnu literaturu koja se bavi ovim pitanjima.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Preservatives, colorants and UV filters in cosmetic products: Safety aspects, Konzervansi, sredstva za bojenje i UV filteri u kozmetičkim proizvodima - aspekti bezbedne primene",
volume = "68",
number = "5",
pages = "934-948",
doi = "10.5937/ArhFarm1805934L"
}

Lukić, M.. (2018). Preservatives, colorants and UV filters in cosmetic products: Safety aspects. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 68(5), 934-948.
https://doi.org/10.5937/ArhFarm1805934L

Lukić M. Preservatives, colorants and UV filters in cosmetic products: Safety aspects. in Arhiv za farmaciju. 2018;68(5):934-948.
doi:10.5937/ArhFarm1805934L .

Lukić, Milica, "Preservatives, colorants and UV filters in cosmetic products: Safety aspects" in Arhiv za farmaciju, 68, no. 5 (2018):934-948,
https://doi.org/10.5937/ArhFarm1805934L . .

TY  - JOUR
AU  - Filipović, Mila
AU  - Lukić, Milica
AU  - Savić, Snežana
AU  - Vuleta, Gordana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3100
AB  - In the cosmetic industry, a frequent anti-aging approach is the protection of cells responsible for the continuous skin renewal and the maintenance of its barrier function - epidermal stem cells, using the secondary metabolites and epigenetic factors of the plant stem cells. Alp rose stem cells (ARSC) extract in liposomes is used as a cosmetic active ingredient in the cosmetic products for the skin care and its protection. According to the manufacturer, this cosmetic active ingredient possess the ability to increase the vitality of epidermal stem cells, protects them against the negative external influences, affects the regeneration of epidermal cells, improves the skin barrier function and has certain anti-aging effects. However, in order for these effects to be observed in in vivo conditions and for ARSC epigenetic factors and secondary metabolites to reach their target places, liposomes in the cosmetic products should remain intact and unchanged. Therefore, according to the EU regulations on the cosmetic products (Regulations 1223/2009 and 655/2013), cosmetic products with plant (alp rose) stem cells can not be attributed to the effects of the containing cosmetic ingredients, and any claims about the each product efficacy has to be supported by the data obtained on the human volunteers.
AB  - U industriji kozmetičkih proizvoda, čest anti-aging pristup jeste zaštita ćelija odgovornih za kontinuirano obnavljanje kože i održavanje njene barijerne funkcije - epidermalnih matičnih ćelija, upotrebom sekundarnih metabolita i epigenetskih faktora biljnih matičnih ćelija. Kao kozmetički aktivna supstanca (KAS) u proizvodima za negu i zaštitu kože, koristi se i ekstrakt matičnih ćelija alpske ruže (MĆAR) inkapsuliran u liposome, za koji proizvođač navodi da povećava otpornost humanih matičnih ćelija kože, štiti ih od negativnih spoljašnjih uticaja, utiče na regeneraciju epidermalnih ćelija, popravlja barijernu funkciju kože i ima određene anti-aging efekte. Međutim, da bi pomenuti efekti bili ispoljeni i u in vivo uslovima, a epigenetski faktori i sekundarni metaboliti MĆAR stigli do ciljnih mesta njihovog delovanja, liposomi u kozmetičkom proizvodu treba da ostanu neoštećeni i neizmenjenih osobina. Stoga, shodno važećim propisima o kozmetičkim proizvodima u EU (Uredbe 1223/2009 i 655/2013), gotovim kozmetičkim proizvodima sa biljnim matičnim ćelijama (alpske ruže) se ne mogu pripisati kozmetički efekti sastojaka koje sadrže, već eventualne tvrdnje o efikasnosti svakog proizvoda treba potkrepiti dokumentacijom o proceni njegovih efekata na humanim dobrovoljcima.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin
T1  - Matične ćelije alpske ruže kao sastojci kozmetičkih kremova - očekivani i utvrđeni efekti kremova na koži
VL  - 68
IS  - 4
SP  - 874
EP  - 884
DO  - 10.5937/ArhFarm1804874F
ER  - 

@article{
author = "Filipović, Mila and Lukić, Milica and Savić, Snežana and Vuleta, Gordana",
year = "2018",
abstract = "In the cosmetic industry, a frequent anti-aging approach is the protection of cells responsible for the continuous skin renewal and the maintenance of its barrier function - epidermal stem cells, using the secondary metabolites and epigenetic factors of the plant stem cells. Alp rose stem cells (ARSC) extract in liposomes is used as a cosmetic active ingredient in the cosmetic products for the skin care and its protection. According to the manufacturer, this cosmetic active ingredient possess the ability to increase the vitality of epidermal stem cells, protects them against the negative external influences, affects the regeneration of epidermal cells, improves the skin barrier function and has certain anti-aging effects. However, in order for these effects to be observed in in vivo conditions and for ARSC epigenetic factors and secondary metabolites to reach their target places, liposomes in the cosmetic products should remain intact and unchanged. Therefore, according to the EU regulations on the cosmetic products (Regulations 1223/2009 and 655/2013), cosmetic products with plant (alp rose) stem cells can not be attributed to the effects of the containing cosmetic ingredients, and any claims about the each product efficacy has to be supported by the data obtained on the human volunteers., U industriji kozmetičkih proizvoda, čest anti-aging pristup jeste zaštita ćelija odgovornih za kontinuirano obnavljanje kože i održavanje njene barijerne funkcije - epidermalnih matičnih ćelija, upotrebom sekundarnih metabolita i epigenetskih faktora biljnih matičnih ćelija. Kao kozmetički aktivna supstanca (KAS) u proizvodima za negu i zaštitu kože, koristi se i ekstrakt matičnih ćelija alpske ruže (MĆAR) inkapsuliran u liposome, za koji proizvođač navodi da povećava otpornost humanih matičnih ćelija kože, štiti ih od negativnih spoljašnjih uticaja, utiče na regeneraciju epidermalnih ćelija, popravlja barijernu funkciju kože i ima određene anti-aging efekte. Međutim, da bi pomenuti efekti bili ispoljeni i u in vivo uslovima, a epigenetski faktori i sekundarni metaboliti MĆAR stigli do ciljnih mesta njihovog delovanja, liposomi u kozmetičkom proizvodu treba da ostanu neoštećeni i neizmenjenih osobina. Stoga, shodno važećim propisima o kozmetičkim proizvodima u EU (Uredbe 1223/2009 i 655/2013), gotovim kozmetičkim proizvodima sa biljnim matičnim ćelijama (alpske ruže) se ne mogu pripisati kozmetički efekti sastojaka koje sadrže, već eventualne tvrdnje o efikasnosti svakog proizvoda treba potkrepiti dokumentacijom o proceni njegovih efekata na humanim dobrovoljcima.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin, Matične ćelije alpske ruže kao sastojci kozmetičkih kremova - očekivani i utvrđeni efekti kremova na koži",
volume = "68",
number = "4",
pages = "874-884",
doi = "10.5937/ArhFarm1804874F"
}

Filipović, M., Lukić, M., Savić, S.,& Vuleta, G.. (2018). Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 68(4), 874-884.
https://doi.org/10.5937/ArhFarm1804874F

Filipović M, Lukić M, Savić S, Vuleta G. Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin. in Arhiv za farmaciju. 2018;68(4):874-884.
doi:10.5937/ArhFarm1804874F .

Filipović, Mila, Lukić, Milica, Savić, Snežana, Vuleta, Gordana, "Alp rose stem cells as cosmetic creams ingredient: Expected and established creams effects on the skin" in Arhiv za farmaciju, 68, no. 4 (2018):874-884,
https://doi.org/10.5937/ArhFarm1804874F . .

TY  - JOUR
AU  - Bubić-Pajić, Nataša
AU  - Todosijević, Marija N.
AU  - Vuleta, Gordana
AU  - Cekić, Nebojša
AU  - Dobričić, Vladimir
AU  - Vučen, Sonja
AU  - Čalija, Bojan
AU  - Lukić, Milica
AU  - Ilić, Tanja
AU  - Savić, Snežana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2837
AB  - Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth-7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs.
PB  - Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb
T2  - Acta Pharmaceutica
T1  - Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance
VL  - 67
IS  - 4
SP  - 415
EP  - 439
DO  - 10.1515/acph-2017-0036
ER  - 

@article{
author = "Bubić-Pajić, Nataša and Todosijević, Marija N. and Vuleta, Gordana and Cekić, Nebojša and Dobričić, Vladimir and Vučen, Sonja and Čalija, Bojan and Lukić, Milica and Ilić, Tanja and Savić, Snežana",
year = "2017",
abstract = "Two types of biocompatible surfactants were evaluated for their capability to formulate skin-friendly/non-irritant microemulsions as vehicles for two poorly water-soluble model drugs differing in properties and concentrations: alkyl polyglucosides (decyl glucoside and caprylyl/capryl glucoside) and ethoxylated surfactants (glycereth-7-caprylate/caprate and polysorbate 80). Phase behavior, structural inversion and microemulsion solubilization potential for sertaconazole nitrate and adapalene were found to be highly dependent on the surfactants structure and HLB value. Performed characterization (polarized light microscopy, pH, electrical conductivity, rheological, FTIR and DSC measurements) indicated a formulation containing glycereth-7-caprylate/caprate as suitable for incorporation of both drugs, whereas alkyl polyglucoside-based systems did not exhibit satisfying solubilization capacity for sertaconazole nitrate. Further, monitored parameters were strongly affected by sertaconazole nitrate incorporation, while they remained almost unchanged in adapalene-loaded vehicles. In addition, results of the in vivo skin performance study supported acceptable tolerability for all investigated formulations, suggesting selected microemulsions as promising carriers worth exploring further for effective skin delivery of model drugs.",
publisher = "Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb",
journal = "Acta Pharmaceutica",
title = "Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance",
volume = "67",
number = "4",
pages = "415-439",
doi = "10.1515/acph-2017-0036"
}

Bubić-Pajić, N., Todosijević, M. N., Vuleta, G., Cekić, N., Dobričić, V., Vučen, S., Čalija, B., Lukić, M., Ilić, T.,& Savić, S.. (2017). Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance. in Acta Pharmaceutica
Hrvatsko Farmaceutsko Drustov (HFD)-Croation Pharmaceutical Soc, Zagreb., 67(4), 415-439.
https://doi.org/10.1515/acph-2017-0036

Bubić-Pajić N, Todosijević MN, Vuleta G, Cekić N, Dobričić V, Vučen S, Čalija B, Lukić M, Ilić T, Savić S. Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance. in Acta Pharmaceutica. 2017;67(4):415-439.
doi:10.1515/acph-2017-0036 .

Bubić-Pajić, Nataša, Todosijević, Marija N., Vuleta, Gordana, Cekić, Nebojša, Dobričić, Vladimir, Vučen, Sonja, Čalija, Bojan, Lukić, Milica, Ilić, Tanja, Savić, Snežana, "Alkyl polyglucoside vs. ethoxylated surfactant-based microemulsions as vehicles for two poorly water-soluble drugs: physicochemical characterization and in vivo skin performance" in Acta Pharmaceutica, 67, no. 4 (2017):415-439,
https://doi.org/10.1515/acph-2017-0036 . .

TY  - JOUR
AU  - Savić, Vedrana
AU  - Todosijević, Marija N.
AU  - Ilić, Tanja
AU  - Lukić, Milica
AU  - Mitsou, Evgenia
AU  - Papadimitriou, Vassiliki
AU  - Avramiotis, Spyridon
AU  - Marković, Bojan
AU  - Cekić, Nebojša
AU  - Savić, Snežana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2823
AB  - In order to improve skin penetration of tacrolimus we aimed to develop potentially non-irritant, lecithin-based microemulsions containing ethanol, isopropanol and/or propylene glycol as cosurfactants, varying caprylic/capric triglycerides and propylene glycol monocaprylate as oil phase. The influence of excipients on the size of microemulsion region in pseudo-ternary phase diagrams and their ability to form different types of microemulsions was evaluated. The comprehensive physicochemical characterization of microemulsions and the evaluation of their structure was performed, while the localization of tacrolimus in microemulsions was further investigated using electron paramagnetic resonance spectroscopy. Moreover, stability studies proved no change in tacrolimus content during one year of storage at room temperature. In addition, in vivo skin performance indicated no skin irritation potential of blank microemulsions, whereas in vitro release testing using Franz diffusion cells showed superior release rate of tacrolimus from microemulsions (0.98 +/- 0.10 and 0.92 +/- 0.11 mu g/cm(2)/h for two bicontinuous and 1.00 +/- 0.24 mu g/cm(2)/h for oil-in-water microemulsion) compared to referent Protopic ointment (0.15 +/- 0.08 mu g/cm(2)/h). Furthermore, ex vivo penetration assessed through porcine ear skin using tape stripping, confirmed superiority of two microemulsions related to the reference, implying developed microemulsions as promising carriers for dermal delivery of tacrolimus.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances
VL  - 529
IS  - 1-2
SP  - 491
EP  - 505
DO  - 10.1016/j.ijpharm.2017.07.036
ER  - 

@article{
author = "Savić, Vedrana and Todosijević, Marija N. and Ilić, Tanja and Lukić, Milica and Mitsou, Evgenia and Papadimitriou, Vassiliki and Avramiotis, Spyridon and Marković, Bojan and Cekić, Nebojša and Savić, Snežana",
year = "2017",
abstract = "In order to improve skin penetration of tacrolimus we aimed to develop potentially non-irritant, lecithin-based microemulsions containing ethanol, isopropanol and/or propylene glycol as cosurfactants, varying caprylic/capric triglycerides and propylene glycol monocaprylate as oil phase. The influence of excipients on the size of microemulsion region in pseudo-ternary phase diagrams and their ability to form different types of microemulsions was evaluated. The comprehensive physicochemical characterization of microemulsions and the evaluation of their structure was performed, while the localization of tacrolimus in microemulsions was further investigated using electron paramagnetic resonance spectroscopy. Moreover, stability studies proved no change in tacrolimus content during one year of storage at room temperature. In addition, in vivo skin performance indicated no skin irritation potential of blank microemulsions, whereas in vitro release testing using Franz diffusion cells showed superior release rate of tacrolimus from microemulsions (0.98 +/- 0.10 and 0.92 +/- 0.11 mu g/cm(2)/h for two bicontinuous and 1.00 +/- 0.24 mu g/cm(2)/h for oil-in-water microemulsion) compared to referent Protopic ointment (0.15 +/- 0.08 mu g/cm(2)/h). Furthermore, ex vivo penetration assessed through porcine ear skin using tape stripping, confirmed superiority of two microemulsions related to the reference, implying developed microemulsions as promising carriers for dermal delivery of tacrolimus.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances",
volume = "529",
number = "1-2",
pages = "491-505",
doi = "10.1016/j.ijpharm.2017.07.036"
}

Savić, V., Todosijević, M. N., Ilić, T., Lukić, M., Mitsou, E., Papadimitriou, V., Avramiotis, S., Marković, B., Cekić, N.,& Savić, S.. (2017). Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 529(1-2), 491-505.
https://doi.org/10.1016/j.ijpharm.2017.07.036

Savić V, Todosijević MN, Ilić T, Lukić M, Mitsou E, Papadimitriou V, Avramiotis S, Marković B, Cekić N, Savić S. Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances. in International Journal of Pharmaceutics. 2017;529(1-2):491-505.
doi:10.1016/j.ijpharm.2017.07.036 .

Savić, Vedrana, Todosijević, Marija N., Ilić, Tanja, Lukić, Milica, Mitsou, Evgenia, Papadimitriou, Vassiliki, Avramiotis, Spyridon, Marković, Bojan, Cekić, Nebojša, Savić, Snežana, "Tacrolimus loaded biocompatible lecithin-based microemulsions with improved skin penetration: Structure characterization and in vitro/in vivo performances" in International Journal of Pharmaceutics, 529, no. 1-2 (2017):491-505,
https://doi.org/10.1016/j.ijpharm.2017.07.036 . .

TY  - JOUR
AU  - Filipović, M.
AU  - Lukić, Milica
AU  - Đorđević, S.
AU  - Krstonosić, Veljko
AU  - Pantelić, Ivana
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2839
AB  - OBJECTIVE: Consumers' demand for improved products' performance, alongside with the obligation of meeting the safety and efficacy goals, presents a key reason for the reformulation, as well as a challenging task for formulators. Any change of the formulation, whether it is wanted - in order to innovate the product (new actives and raw materials) or necessary - due to, for example legislative changes (restriction of ingredients), ingredients market unavailability, new manufacturing equipment, may have a number of consequences, desired or otherwise. The aim of the study was to evaluate the influence of multiple factors - variations of the composition, manufacturing conditions and their interactions, on emulsion textural and rheological characteristics, applying the general experimental factorial design and, subsequently, to establish the approach that could replace, to some extent, certain expensive and time-consuming tests (e.g. certain sensory analysis), often required, partly or completely, after the reformulation. METHODS: An experimental design strategy was utilized to reveal the influence of reformulation factors (addition of new actives, preparation method change) on textural and rheological properties of cosmetic emulsions, especially those linked to certain sensorial attributes, and droplet size. RESULTS: The general experimental factorial design revealed a significant direct effect of each factor, as well as their interaction effects, on certain characteristics of the system and provided some valuable information necessary for fine-tuning reformulation conditions. Upon addition of STEM-liposomes, consistency, index of viscosity, firmness and cohesiveness were decreased, as along with certain rheology parameters (elastic and viscous modulus), whereas maximal and minimal apparent viscosities and droplet size were increased. The presence of an emollient (squalene) affected all the investigated parameters in a concentration-dependent manner. Modification of the preparation method (using Ultra Turrax instead of a propeller stirrer) produced emulsions with higher firmness and maximal apparent viscosity, but led to a decrease in minimal apparent viscosity, hysteresis loop area, all monitored parameters of oscillatory rheology and droplet size. CONCLUSION: The study showed that the established approach which combines a general experimental design and instrumental, rheological and textural measurements could be appropriate, more objective, repeatable and time and money-saving step towards developing cosmetic emulsions with satisfying, improved or unchanged, consumer-acceptable performance during the reformulation.
PB  - Wiley, Hoboken
T2  - International Journal of Cosmetic Science
T1  - Towards satisfying performance of an O/W cosmetic emulsion: screening of reformulation factors on textural and rheological properties using general experimental design
VL  - 39
IS  - 5
SP  - 486
EP  - 499
DO  - 10.1111/ics.12402
ER  - 

@article{
author = "Filipović, M. and Lukić, Milica and Đorđević, S. and Krstonosić, Veljko and Pantelić, Ivana and Vuleta, Gordana and Savić, Snežana",
year = "2017",
abstract = "OBJECTIVE: Consumers' demand for improved products' performance, alongside with the obligation of meeting the safety and efficacy goals, presents a key reason for the reformulation, as well as a challenging task for formulators. Any change of the formulation, whether it is wanted - in order to innovate the product (new actives and raw materials) or necessary - due to, for example legislative changes (restriction of ingredients), ingredients market unavailability, new manufacturing equipment, may have a number of consequences, desired or otherwise. The aim of the study was to evaluate the influence of multiple factors - variations of the composition, manufacturing conditions and their interactions, on emulsion textural and rheological characteristics, applying the general experimental factorial design and, subsequently, to establish the approach that could replace, to some extent, certain expensive and time-consuming tests (e.g. certain sensory analysis), often required, partly or completely, after the reformulation. METHODS: An experimental design strategy was utilized to reveal the influence of reformulation factors (addition of new actives, preparation method change) on textural and rheological properties of cosmetic emulsions, especially those linked to certain sensorial attributes, and droplet size. RESULTS: The general experimental factorial design revealed a significant direct effect of each factor, as well as their interaction effects, on certain characteristics of the system and provided some valuable information necessary for fine-tuning reformulation conditions. Upon addition of STEM-liposomes, consistency, index of viscosity, firmness and cohesiveness were decreased, as along with certain rheology parameters (elastic and viscous modulus), whereas maximal and minimal apparent viscosities and droplet size were increased. The presence of an emollient (squalene) affected all the investigated parameters in a concentration-dependent manner. Modification of the preparation method (using Ultra Turrax instead of a propeller stirrer) produced emulsions with higher firmness and maximal apparent viscosity, but led to a decrease in minimal apparent viscosity, hysteresis loop area, all monitored parameters of oscillatory rheology and droplet size. CONCLUSION: The study showed that the established approach which combines a general experimental design and instrumental, rheological and textural measurements could be appropriate, more objective, repeatable and time and money-saving step towards developing cosmetic emulsions with satisfying, improved or unchanged, consumer-acceptable performance during the reformulation.",
publisher = "Wiley, Hoboken",
journal = "International Journal of Cosmetic Science",
title = "Towards satisfying performance of an O/W cosmetic emulsion: screening of reformulation factors on textural and rheological properties using general experimental design",
volume = "39",
number = "5",
pages = "486-499",
doi = "10.1111/ics.12402"
}

Filipović, M., Lukić, M., Đorđević, S., Krstonosić, V., Pantelić, I., Vuleta, G.,& Savić, S.. (2017). Towards satisfying performance of an O/W cosmetic emulsion: screening of reformulation factors on textural and rheological properties using general experimental design. in International Journal of Cosmetic Science
Wiley, Hoboken., 39(5), 486-499.
https://doi.org/10.1111/ics.12402

Filipović M, Lukić M, Đorđević S, Krstonosić V, Pantelić I, Vuleta G, Savić S. Towards satisfying performance of an O/W cosmetic emulsion: screening of reformulation factors on textural and rheological properties using general experimental design. in International Journal of Cosmetic Science. 2017;39(5):486-499.
doi:10.1111/ics.12402 .

Filipović, M., Lukić, Milica, Đorđević, S., Krstonosić, Veljko, Pantelić, Ivana, Vuleta, Gordana, Savić, Snežana, "Towards satisfying performance of an O/W cosmetic emulsion: screening of reformulation factors on textural and rheological properties using general experimental design" in International Journal of Cosmetic Science, 39, no. 5 (2017):486-499,
https://doi.org/10.1111/ics.12402 . .

TY  - JOUR
AU  - Denić, Dragana
AU  - Lukić, Milica
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3021
AB  - Cosmetic products, labelled and advertised as anti-age, are more precisely cosmetic products intended for the reduction of the visible signs of skin aging. Joint influence of internal and external factors contributes to the process of skin aging, so that dominant signs of aged skin, like hyperpigmentation, fine lines and wrinkles, loss of tone and elasticity of the skin become visible. Aging skin loses its radiance and gloss, while the skin colour becomes uneven. Regular use of appropriate cosmetic products (usually creams and serums) can be useful in the maintenance of youthful-looking skin. The efficacy of these products must be confirmed, and the manufacturers have a number of available techniques and methods for testing the surface of the skin and measuring its biophysical parameters. Users rely on claims when they make a decision on products' choice. Claims that stand out for cosmetic products, which are related to the properties, active ingredients or efficacy of the product, must be substantiated in accordance with the requirements of Cosmetic Regulation EU 1223/2009. Additional relevant regulation is the EU Regulation 655/2013 on cosmetic claims, alongside with corresponding guidelines.
AB  - Kozmetički proizvodi koji su obeleženi i reklamiraju se kao anti-age, čine vrstu kozmetičkih proizvoda namenjenih umanjenju pojave vidljivih znakova starenja kože. Pod uticajem udruženih unutrašnjih i spoljašnjih faktora koji doprinose procesu starenja kože, javljaju se dominantni znakovi poput hiperpigmentacija, finih linija i bora, gubitka tonusa i elastičnosti kože. Koža koja stari gubi blistavost, a ton i boja kože postaju neujednačeni. Redovnom upotrebom odgovarajućih kozmetičkih proizvoda (najčešće krema i seruma), mogu se postići značajni rezultati u očuvanju mladalačkog izgleda kože. Efikasnost ovih proizvoda mora biti potvrđena, a proizvođačima su dostupne brojne tehnike i metode za ispitivanje površine kože i merenje njenih biofizičkih parametara. Tvrdnje koje se ističu o kozmetičkom proizvodu, a u vezi su sa osobinama, aktivnim supstancama ili efikasnošću proizvoda, moraju se dokazati u skladu sa zahtevima Kozmetičke Uredbe EU 1223/2009, kako bi korisnici bili sigurni u proizvod koji su odabrali. U iznošenju tvrdnji o efektima, odnosno karakteristikama kozmetičkog proizvoda, dodatno se moraju poštovati zahtevi Uredbe EU 655/2013 o kozmetičkim tvrdnjama i odgovarajućih smernica/vodiča.
PB  - Savez farmaceutskih udruženja Srbije, Beograd
T2  - Arhiv za farmaciju
T1  - Effects of anti-age cosmetic products: Claims substantiation
T1  - Efekti anti-age kozmetičkih proizvoda - dokazivanje tvrdnji
VL  - 67
IS  - 3
SP  - 209
EP  - 219
DO  - 10.5937/arhfarm1703209D
ER  - 

@article{
author = "Denić, Dragana and Lukić, Milica and Vuleta, Gordana and Savić, Snežana",
year = "2017",
abstract = "Cosmetic products, labelled and advertised as anti-age, are more precisely cosmetic products intended for the reduction of the visible signs of skin aging. Joint influence of internal and external factors contributes to the process of skin aging, so that dominant signs of aged skin, like hyperpigmentation, fine lines and wrinkles, loss of tone and elasticity of the skin become visible. Aging skin loses its radiance and gloss, while the skin colour becomes uneven. Regular use of appropriate cosmetic products (usually creams and serums) can be useful in the maintenance of youthful-looking skin. The efficacy of these products must be confirmed, and the manufacturers have a number of available techniques and methods for testing the surface of the skin and measuring its biophysical parameters. Users rely on claims when they make a decision on products' choice. Claims that stand out for cosmetic products, which are related to the properties, active ingredients or efficacy of the product, must be substantiated in accordance with the requirements of Cosmetic Regulation EU 1223/2009. Additional relevant regulation is the EU Regulation 655/2013 on cosmetic claims, alongside with corresponding guidelines., Kozmetički proizvodi koji su obeleženi i reklamiraju se kao anti-age, čine vrstu kozmetičkih proizvoda namenjenih umanjenju pojave vidljivih znakova starenja kože. Pod uticajem udruženih unutrašnjih i spoljašnjih faktora koji doprinose procesu starenja kože, javljaju se dominantni znakovi poput hiperpigmentacija, finih linija i bora, gubitka tonusa i elastičnosti kože. Koža koja stari gubi blistavost, a ton i boja kože postaju neujednačeni. Redovnom upotrebom odgovarajućih kozmetičkih proizvoda (najčešće krema i seruma), mogu se postići značajni rezultati u očuvanju mladalačkog izgleda kože. Efikasnost ovih proizvoda mora biti potvrđena, a proizvođačima su dostupne brojne tehnike i metode za ispitivanje površine kože i merenje njenih biofizičkih parametara. Tvrdnje koje se ističu o kozmetičkom proizvodu, a u vezi su sa osobinama, aktivnim supstancama ili efikasnošću proizvoda, moraju se dokazati u skladu sa zahtevima Kozmetičke Uredbe EU 1223/2009, kako bi korisnici bili sigurni u proizvod koji su odabrali. U iznošenju tvrdnji o efektima, odnosno karakteristikama kozmetičkog proizvoda, dodatno se moraju poštovati zahtevi Uredbe EU 655/2013 o kozmetičkim tvrdnjama i odgovarajućih smernica/vodiča.",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Effects of anti-age cosmetic products: Claims substantiation, Efekti anti-age kozmetičkih proizvoda - dokazivanje tvrdnji",
volume = "67",
number = "3",
pages = "209-219",
doi = "10.5937/arhfarm1703209D"
}

Denić, D., Lukić, M., Vuleta, G.,& Savić, S.. (2017). Effects of anti-age cosmetic products: Claims substantiation. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 67(3), 209-219.
https://doi.org/10.5937/arhfarm1703209D

Denić D, Lukić M, Vuleta G, Savić S. Effects of anti-age cosmetic products: Claims substantiation. in Arhiv za farmaciju. 2017;67(3):209-219.
doi:10.5937/arhfarm1703209D .

Denić, Dragana, Lukić, Milica, Vuleta, Gordana, Savić, Snežana, "Effects of anti-age cosmetic products: Claims substantiation" in Arhiv za farmaciju, 67, no. 3 (2017):209-219,
https://doi.org/10.5937/arhfarm1703209D . .

TY  - JOUR
AU  - Heck, Rouven
AU  - Lukić, Milica
AU  - Savić, Snežana
AU  - Daniels, Rolf
AU  - Lunter, Dominique
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2806
AB  - Aim: The purpose of this study was to evaluate skin permeation and penetration of nonivamide which has been formulated in novel film-forming formulations (FFFs). These formulations aim to prolong the availability of capsaicinoids which are used in long-term treatment of chronic pruritus. Methods: An oily solution of nonivamide was loaded into porous silica particles which then were suspended in an aqueous dispersion of a sustained release polymer. Permeation and penetration experiments were performed ex vivo with postauricular porcine skin using modified Franz diffusion cells. The penetrated drug amount was assessed ex vivo by skin surface biopsy followed by cryo-sectioning. Furthermore, in vivo skin irritation experiments were performed to compare the potential skin irritation caused by the FFFs to conventionally used semi-solid formulations. Results: Permeation rates of nonivamide from FFF through the skin are comparable to that from clinically used immediate release formulations. This elucidates the therapeutic safety profile of the novel FFF. Penetration studies confirmed the prolonged drug availability at the site of action. FFFs were found not to irritate the skin of healthy volunteers. Conclusion: FFFs with sustained nonivamide penetration represent safe and easy-to-use formulations. They therefore may improve the treatment of chronic pruritus with capsaicinoids by enhancing patient compliance through a sustained release regime.
PB  - Elsevier Science BV, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - Ex vivo skin permeation and penetration of nonivamide from and in vivo skin tolerability of film-forming formulations containing porous silica
VL  - 106
SP  - 34
EP  - 40
DO  - 10.1016/j.ejps.2017.05.045
ER  - 

@article{
author = "Heck, Rouven and Lukić, Milica and Savić, Snežana and Daniels, Rolf and Lunter, Dominique",
year = "2017",
abstract = "Aim: The purpose of this study was to evaluate skin permeation and penetration of nonivamide which has been formulated in novel film-forming formulations (FFFs). These formulations aim to prolong the availability of capsaicinoids which are used in long-term treatment of chronic pruritus. Methods: An oily solution of nonivamide was loaded into porous silica particles which then were suspended in an aqueous dispersion of a sustained release polymer. Permeation and penetration experiments were performed ex vivo with postauricular porcine skin using modified Franz diffusion cells. The penetrated drug amount was assessed ex vivo by skin surface biopsy followed by cryo-sectioning. Furthermore, in vivo skin irritation experiments were performed to compare the potential skin irritation caused by the FFFs to conventionally used semi-solid formulations. Results: Permeation rates of nonivamide from FFF through the skin are comparable to that from clinically used immediate release formulations. This elucidates the therapeutic safety profile of the novel FFF. Penetration studies confirmed the prolonged drug availability at the site of action. FFFs were found not to irritate the skin of healthy volunteers. Conclusion: FFFs with sustained nonivamide penetration represent safe and easy-to-use formulations. They therefore may improve the treatment of chronic pruritus with capsaicinoids by enhancing patient compliance through a sustained release regime.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Ex vivo skin permeation and penetration of nonivamide from and in vivo skin tolerability of film-forming formulations containing porous silica",
volume = "106",
pages = "34-40",
doi = "10.1016/j.ejps.2017.05.045"
}

Heck, R., Lukić, M., Savić, S., Daniels, R.,& Lunter, D.. (2017). Ex vivo skin permeation and penetration of nonivamide from and in vivo skin tolerability of film-forming formulations containing porous silica. in European Journal of Pharmaceutical Sciences
Elsevier Science BV, Amsterdam., 106, 34-40.
https://doi.org/10.1016/j.ejps.2017.05.045

Heck R, Lukić M, Savić S, Daniels R, Lunter D. Ex vivo skin permeation and penetration of nonivamide from and in vivo skin tolerability of film-forming formulations containing porous silica. in European Journal of Pharmaceutical Sciences. 2017;106:34-40.
doi:10.1016/j.ejps.2017.05.045 .

Heck, Rouven, Lukić, Milica, Savić, Snežana, Daniels, Rolf, Lunter, Dominique, "Ex vivo skin permeation and penetration of nonivamide from and in vivo skin tolerability of film-forming formulations containing porous silica" in European Journal of Pharmaceutical Sciences, 106 (2017):34-40,
https://doi.org/10.1016/j.ejps.2017.05.045 . .

TY  - JOUR
AU  - Isailović, Tanja
AU  - Đorđević, Sanela
AU  - Marković, Bojan
AU  - Randelović, Danijela
AU  - Cekić, Nebojša
AU  - Lukić, Milica
AU  - Pantelić, Ivana
AU  - Daniels, Rolf
AU  - Savić, Snežana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2716
AB  - We aimed to develop lecithin-based nanoemulsions intended for effective aceclofenac (ACF) skin delivery utilizing sucrose esters [sucrose palmitate (SP) and sucrose stearate (SS)] as additional stabilizers and penetration enhancers. To find the suitable surfactant mixtures and levels of process variables (homogenization pressure and number of cycles-high pressure homogenization manufacturing method) that result in drug-loaded nanoemulsions with minimal droplet size and narrow size distribution, a combined mixture-process experimental design was employed. Based on optimization data, selected nanoemulsions were evaluated regarding morphology, surface charge, drug-excipient interactions, physical stability, and in vivo skin performances (skin penetration and irritation potential). The predicted physicochemical properties and storage stability were proved satisfying for ACF-loaded nanoemulsions containing 2% of SP in the blend with 0%-1% of SS and 1%-2% of egg lecithin (produced at 50 degrees C/20 cycles/800 bar). Additionally, the in vivo tape stripping demonstrated superior ACF skin absorption from these nanoemulsions, particularly from those containing 2% of SP, 0.5% of SS, and 1.5% of egg lecithin, when comparing with the sample costabilized by conventional surfactant-polysorbate 80. In summary, the combined mixture-process experimental design was shown as a feasible tool for formulation development of multisurfactant-based nanosized delivery systems with potentially improved overall product performances.
PB  - Elsevier Science Inc, New York
T2  - Journal of Pharmaceutical Sciences
T1  - Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design
VL  - 105
IS  - 1
SP  - 308
EP  - 323
DO  - 10.1002/jps.24706
ER  - 

@article{
author = "Isailović, Tanja and Đorđević, Sanela and Marković, Bojan and Randelović, Danijela and Cekić, Nebojša and Lukić, Milica and Pantelić, Ivana and Daniels, Rolf and Savić, Snežana",
year = "2016",
abstract = "We aimed to develop lecithin-based nanoemulsions intended for effective aceclofenac (ACF) skin delivery utilizing sucrose esters [sucrose palmitate (SP) and sucrose stearate (SS)] as additional stabilizers and penetration enhancers. To find the suitable surfactant mixtures and levels of process variables (homogenization pressure and number of cycles-high pressure homogenization manufacturing method) that result in drug-loaded nanoemulsions with minimal droplet size and narrow size distribution, a combined mixture-process experimental design was employed. Based on optimization data, selected nanoemulsions were evaluated regarding morphology, surface charge, drug-excipient interactions, physical stability, and in vivo skin performances (skin penetration and irritation potential). The predicted physicochemical properties and storage stability were proved satisfying for ACF-loaded nanoemulsions containing 2% of SP in the blend with 0%-1% of SS and 1%-2% of egg lecithin (produced at 50 degrees C/20 cycles/800 bar). Additionally, the in vivo tape stripping demonstrated superior ACF skin absorption from these nanoemulsions, particularly from those containing 2% of SP, 0.5% of SS, and 1.5% of egg lecithin, when comparing with the sample costabilized by conventional surfactant-polysorbate 80. In summary, the combined mixture-process experimental design was shown as a feasible tool for formulation development of multisurfactant-based nanosized delivery systems with potentially improved overall product performances.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Pharmaceutical Sciences",
title = "Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design",
volume = "105",
number = "1",
pages = "308-323",
doi = "10.1002/jps.24706"
}

Isailović, T., Đorđević, S., Marković, B., Randelović, D., Cekić, N., Lukić, M., Pantelić, I., Daniels, R.,& Savić, S.. (2016). Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design. in Journal of Pharmaceutical Sciences
Elsevier Science Inc, New York., 105(1), 308-323.
https://doi.org/10.1002/jps.24706

Isailović T, Đorđević S, Marković B, Randelović D, Cekić N, Lukić M, Pantelić I, Daniels R, Savić S. Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design. in Journal of Pharmaceutical Sciences. 2016;105(1):308-323.
doi:10.1002/jps.24706 .

Isailović, Tanja, Đorđević, Sanela, Marković, Bojan, Randelović, Danijela, Cekić, Nebojša, Lukić, Milica, Pantelić, Ivana, Daniels, Rolf, Savić, Snežana, "Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design" in Journal of Pharmaceutical Sciences, 105, no. 1 (2016):308-323,
https://doi.org/10.1002/jps.24706 . .

TY  - JOUR
AU  - Filipović, Mila
AU  - Gledović, Ana
AU  - Lukić, Milica
AU  - Tasić-Kostov, Marija
AU  - Isailović, Tanja
AU  - Pantelić, Ivana
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2628
AB  - Background/Aim. Since skin moisturization may be achieved by both actives and chosen carrier, plant stem cells, squalene and natural alkyl polyglucoside emulsifier may be potential components of contemporary cosmetic products. The aim of the study was in vivo evaluation of the skin irritation potential and the efficacy of Alpine Rose stem cells incorporated into liposomes and olive oil squalene as ingredients of moisturizing creams, with respect to the novel emulsifier used for creams' stabilization. Methods. With the employment of noninvasive skin biophysical measurements, skin hydration (EC), transepidermal water loss (TEWL), erythema index (EI) and viscoelasticity were measured on 76 healthy volunteers. In the first phase, skin irritation after a 24-hour occlusion and the long-term efficacy of creams (a 21-day study) on healthy skin were evaluated. Phase II of the study focused on the cream efficacy assessment after a 6-day treatment of sodium lauryl sulfate-irritated skin. Results. After a 24-hour occlusion, there were no significant changes in the EI for any tested sample. In the second phase of the study, the EI was not significantly altered for the cream containing squalene, while the application of all active samples resulted in a significant reduction of TEWL. In both phases of the study an EC increase was recorded, especially for the squalene-containing cream. Conclusion. Due to the lack of skin irritation and skin barrier impairment along with the marked hydration effect, it could be said that the investigated actives incorporated into alkyl polyglucoside emulsifier-stabilized creams may be safely applied as ingredients for "tailor-made" cosmetic moisturizers intended for normal and dry skin care, whereas olive oil squalene could be used for the treatment of irritated or sensitive skin as well.
AB  - Uvod/Cilj. S obzirom na to da vlaženje kože može biti postignuto izborom kako aktivnih supstanci, tako i odgovarajućeg nosača, biljne matične ćelije, skvalen i prirodni alkil poliglukozidni emulgator mogu biti potencijalni sastojci savremenih kozmetičkih proizvoda. Cilj ovog rada bio je in vivo procena iritiranog potencijala i efikasnosti matičnih ćelija alpske ruže dodatih u liposome i skvalena maslinovog ulja, kao sastojaka vlažećih krema, imajući u vidu nov emulgator koji je korišćen za njihovu stabilizaciju. Metode. Upotrebom neinvazivnih metoda zasnovanih na biofizičkim merenjima na koži, kod 76 zdravih dobrovoljaca mereni su: hidratacija kože (EC), transepidermalni gubitak vlage (TEWL), eritema indeks (EI) i viskoelastičnost kože. U prvoj fazi studije vršena je procena iritacije kože nakon 24-h okluzije, kao i procena efikasnosti krema nakon primene na zdravoj koži dobrovoljaca u trajanju od 21 dana. Druga faza studije bila je bazirana na proceni efikasnosti krema nakon 6-dnevnog tretmana kože prethodno iritirane natrijum-lauril-sulfatom. Rezultati. Nakon 24-h okluzije nije bilo značajne promene vrednosti EI ni kod jednog ispitivanog krema. U drugoj fazi studije, krem sa skvalenom nije značajno uticao na promenu vrednosti EI, dok je primena svih aktivnih krema dovela do značajnog sniženja vrednosti TEWL. U obe faze studije zabeležen je porast EC, naročito nakon primene krema koji sadrži skvalen. Zaključak. Uzevši u obzir odsustvo nadraženosti kože i narušavanja kožne barijere, kao i porast hidratacije površinskog sloja kože, može se reći da se ispitivane aktivne supstance ubačene u kreme stabilizovane alkil-poliglukozidnim emulgatorom mogu bezbedno koristiti kao komponente tzv. "skrojenih" kozmetičkih ovlaživača namenjenih za negu zdrave i suve kože, dok se skvalen maslinovog ulja može koristiti i za negu iritirane i osetljive kože.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficiency on normal and sodium lauryl sulfate-irritated skin?
T1  - Matične ćelije alpske ruže, skvalen maslinovog ulja i prirodni alkil-poliglukozidni emulgator - da li su odgovarajući sastojci kremova za vlaženje - in vivo efikasnost na zdravoj i koži iritiranoj natrijum lauril sulfatom?
VL  - 73
IS  - 11
SP  - 991
EP  - 1002
DO  - 10.2298/VSP150116122F
ER  - 

@article{
author = "Filipović, Mila and Gledović, Ana and Lukić, Milica and Tasić-Kostov, Marija and Isailović, Tanja and Pantelić, Ivana and Vuleta, Gordana and Savić, Snežana",
year = "2016",
abstract = "Background/Aim. Since skin moisturization may be achieved by both actives and chosen carrier, plant stem cells, squalene and natural alkyl polyglucoside emulsifier may be potential components of contemporary cosmetic products. The aim of the study was in vivo evaluation of the skin irritation potential and the efficacy of Alpine Rose stem cells incorporated into liposomes and olive oil squalene as ingredients of moisturizing creams, with respect to the novel emulsifier used for creams' stabilization. Methods. With the employment of noninvasive skin biophysical measurements, skin hydration (EC), transepidermal water loss (TEWL), erythema index (EI) and viscoelasticity were measured on 76 healthy volunteers. In the first phase, skin irritation after a 24-hour occlusion and the long-term efficacy of creams (a 21-day study) on healthy skin were evaluated. Phase II of the study focused on the cream efficacy assessment after a 6-day treatment of sodium lauryl sulfate-irritated skin. Results. After a 24-hour occlusion, there were no significant changes in the EI for any tested sample. In the second phase of the study, the EI was not significantly altered for the cream containing squalene, while the application of all active samples resulted in a significant reduction of TEWL. In both phases of the study an EC increase was recorded, especially for the squalene-containing cream. Conclusion. Due to the lack of skin irritation and skin barrier impairment along with the marked hydration effect, it could be said that the investigated actives incorporated into alkyl polyglucoside emulsifier-stabilized creams may be safely applied as ingredients for "tailor-made" cosmetic moisturizers intended for normal and dry skin care, whereas olive oil squalene could be used for the treatment of irritated or sensitive skin as well., Uvod/Cilj. S obzirom na to da vlaženje kože može biti postignuto izborom kako aktivnih supstanci, tako i odgovarajućeg nosača, biljne matične ćelije, skvalen i prirodni alkil poliglukozidni emulgator mogu biti potencijalni sastojci savremenih kozmetičkih proizvoda. Cilj ovog rada bio je in vivo procena iritiranog potencijala i efikasnosti matičnih ćelija alpske ruže dodatih u liposome i skvalena maslinovog ulja, kao sastojaka vlažećih krema, imajući u vidu nov emulgator koji je korišćen za njihovu stabilizaciju. Metode. Upotrebom neinvazivnih metoda zasnovanih na biofizičkim merenjima na koži, kod 76 zdravih dobrovoljaca mereni su: hidratacija kože (EC), transepidermalni gubitak vlage (TEWL), eritema indeks (EI) i viskoelastičnost kože. U prvoj fazi studije vršena je procena iritacije kože nakon 24-h okluzije, kao i procena efikasnosti krema nakon primene na zdravoj koži dobrovoljaca u trajanju od 21 dana. Druga faza studije bila je bazirana na proceni efikasnosti krema nakon 6-dnevnog tretmana kože prethodno iritirane natrijum-lauril-sulfatom. Rezultati. Nakon 24-h okluzije nije bilo značajne promene vrednosti EI ni kod jednog ispitivanog krema. U drugoj fazi studije, krem sa skvalenom nije značajno uticao na promenu vrednosti EI, dok je primena svih aktivnih krema dovela do značajnog sniženja vrednosti TEWL. U obe faze studije zabeležen je porast EC, naročito nakon primene krema koji sadrži skvalen. Zaključak. Uzevši u obzir odsustvo nadraženosti kože i narušavanja kožne barijere, kao i porast hidratacije površinskog sloja kože, može se reći da se ispitivane aktivne supstance ubačene u kreme stabilizovane alkil-poliglukozidnim emulgatorom mogu bezbedno koristiti kao komponente tzv. "skrojenih" kozmetičkih ovlaživača namenjenih za negu zdrave i suve kože, dok se skvalen maslinovog ulja može koristiti i za negu iritirane i osetljive kože.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficiency on normal and sodium lauryl sulfate-irritated skin?, Matične ćelije alpske ruže, skvalen maslinovog ulja i prirodni alkil-poliglukozidni emulgator - da li su odgovarajući sastojci kremova za vlaženje - in vivo efikasnost na zdravoj i koži iritiranoj natrijum lauril sulfatom?",
volume = "73",
number = "11",
pages = "991-1002",
doi = "10.2298/VSP150116122F"
}

Filipović, M., Gledović, A., Lukić, M., Tasić-Kostov, M., Isailović, T., Pantelić, I., Vuleta, G.,& Savić, S.. (2016). Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficiency on normal and sodium lauryl sulfate-irritated skin?. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 73(11), 991-1002.
https://doi.org/10.2298/VSP150116122F

Filipović M, Gledović A, Lukić M, Tasić-Kostov M, Isailović T, Pantelić I, Vuleta G, Savić S. Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficiency on normal and sodium lauryl sulfate-irritated skin?. in Vojnosanitetski pregled. 2016;73(11):991-1002.
doi:10.2298/VSP150116122F .

Filipović, Mila, Gledović, Ana, Lukić, Milica, Tasić-Kostov, Marija, Isailović, Tanja, Pantelić, Ivana, Vuleta, Gordana, Savić, Snežana, "Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers - in vivo efficiency on normal and sodium lauryl sulfate-irritated skin?" in Vojnosanitetski pregled, 73, no. 11 (2016):991-1002,
https://doi.org/10.2298/VSP150116122F . .

TY  - JOUR
AU  - Filipović, Mila
AU  - Lukić, Milica
AU  - Krstonosić, Veljko
AU  - Đorđević, Sanela
AU  - Pantelić, Ivana
AU  - Gledović, Ana
AU  - Vuleta, Gordana
AU  - Savić, Snežana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2527
AB  - During the formulation of liposome-containing products different problems can occur and the selection of a suitable carrier remains the greatest challenge. To estimate feasibility of a novel alkyl polyglucoside surfactant (hydroxystearyl alcohol and hydroxystearyl glucoside) as an emulsifier for cosmetics with liposome-encapsulated plant stem cells, we performed a two-phase study. In the first, the pre-formulation phase, the emulsifier's critical micelle concentration (CMC) and liposome-encapsulated active-emulsifier interactions were determined. The second phase was carried out to develop and characterize a cosmetic emulsion suitable to serve as a carrier for liposomes. The investigated emulsifier, with the obtained CMC value of 0.0085 wt.%, could be classified as liposome-friendly and can be used to develop stable and aesthetically acceptable cosmetics or even prospective pharmaceutical liposome-containing emulsions.
PB  - Carl Hanser Verlag, Munich
T2  - Tenside Surfactants Detergents
T1  - Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies
VL  - 53
IS  - 3
SP  - 214
EP  - 226
DO  - 10.3139/113.110426
ER  - 

@article{
author = "Filipović, Mila and Lukić, Milica and Krstonosić, Veljko and Đorđević, Sanela and Pantelić, Ivana and Gledović, Ana and Vuleta, Gordana and Savić, Snežana",
year = "2016",
abstract = "During the formulation of liposome-containing products different problems can occur and the selection of a suitable carrier remains the greatest challenge. To estimate feasibility of a novel alkyl polyglucoside surfactant (hydroxystearyl alcohol and hydroxystearyl glucoside) as an emulsifier for cosmetics with liposome-encapsulated plant stem cells, we performed a two-phase study. In the first, the pre-formulation phase, the emulsifier's critical micelle concentration (CMC) and liposome-encapsulated active-emulsifier interactions were determined. The second phase was carried out to develop and characterize a cosmetic emulsion suitable to serve as a carrier for liposomes. The investigated emulsifier, with the obtained CMC value of 0.0085 wt.%, could be classified as liposome-friendly and can be used to develop stable and aesthetically acceptable cosmetics or even prospective pharmaceutical liposome-containing emulsions.",
publisher = "Carl Hanser Verlag, Munich",
journal = "Tenside Surfactants Detergents",
title = "Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies",
volume = "53",
number = "3",
pages = "214-226",
doi = "10.3139/113.110426"
}

Filipović, M., Lukić, M., Krstonosić, V., Đorđević, S., Pantelić, I., Gledović, A., Vuleta, G.,& Savić, S.. (2016). Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies. in Tenside Surfactants Detergents
Carl Hanser Verlag, Munich., 53(3), 214-226.
https://doi.org/10.3139/113.110426

Filipović M, Lukić M, Krstonosić V, Đorđević S, Pantelić I, Gledović A, Vuleta G, Savić S. Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies. in Tenside Surfactants Detergents. 2016;53(3):214-226.
doi:10.3139/113.110426 .

Filipović, Mila, Lukić, Milica, Krstonosić, Veljko, Đorđević, Sanela, Pantelić, Ivana, Gledović, Ana, Vuleta, Gordana, Savić, Snežana, "Feasibility of a Natural Surfactant as a Stabilizer for Cosmetics with Liposome-Encapsulated Plant Stem Cells: Pre-Formulation and Formulation Through Stability Studies" in Tenside Surfactants Detergents, 53, no. 3 (2016):214-226,
https://doi.org/10.3139/113.110426 . .

TY  - JOUR
AU  - Lukić, Milica
AU  - Pantelić, Ivana
AU  - Savić, Snežana
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2559
AB  - Novel surfactants which are nowadays available for incorporation into various formulations of personal care and cosmetic products are numerous, implying a permanent need for their classification. This overview provides essential information relating to synthesis, basic physicochemical characteristics, application and other relevant data on surfactants currently used in cosmetic products. In the second part of the paper an outline of acidic active substances with significant application in cosmetic products is given, as well as the problems that arise during preparation/manufacture of the containing formulations, accompanied with the review of scientific publications and other available reliable data dealing with the incorporation of these actives in the cosmetic formulations stabilized with novel (mainly natural) surfactants.
PB  - Carl Hanser Verlag, Munich
T2  - Tenside Surfactants Detergents
T1  - An Overview of Novel Surfactants for Formulation of Cosmetics with Certain Emphasis on Acidic Active Substances
VL  - 53
IS  - 1
SP  - 7
EP  - 19
DO  - 10.3139/113.110405
ER  - 

@article{
author = "Lukić, Milica and Pantelić, Ivana and Savić, Snežana",
year = "2016",
abstract = "Novel surfactants which are nowadays available for incorporation into various formulations of personal care and cosmetic products are numerous, implying a permanent need for their classification. This overview provides essential information relating to synthesis, basic physicochemical characteristics, application and other relevant data on surfactants currently used in cosmetic products. In the second part of the paper an outline of acidic active substances with significant application in cosmetic products is given, as well as the problems that arise during preparation/manufacture of the containing formulations, accompanied with the review of scientific publications and other available reliable data dealing with the incorporation of these actives in the cosmetic formulations stabilized with novel (mainly natural) surfactants.",
publisher = "Carl Hanser Verlag, Munich",
journal = "Tenside Surfactants Detergents",
title = "An Overview of Novel Surfactants for Formulation of Cosmetics with Certain Emphasis on Acidic Active Substances",
volume = "53",
number = "1",
pages = "7-19",
doi = "10.3139/113.110405"
}

Lukić, M., Pantelić, I.,& Savić, S.. (2016). An Overview of Novel Surfactants for Formulation of Cosmetics with Certain Emphasis on Acidic Active Substances. in Tenside Surfactants Detergents
Carl Hanser Verlag, Munich., 53(1), 7-19.
https://doi.org/10.3139/113.110405

Lukić M, Pantelić I, Savić S. An Overview of Novel Surfactants for Formulation of Cosmetics with Certain Emphasis on Acidic Active Substances. in Tenside Surfactants Detergents. 2016;53(1):7-19.
doi:10.3139/113.110405 .

Lukić, Milica, Pantelić, Ivana, Savić, Snežana, "An Overview of Novel Surfactants for Formulation of Cosmetics with Certain Emphasis on Acidic Active Substances" in Tenside Surfactants Detergents, 53, no. 1 (2016):7-19,
https://doi.org/10.3139/113.110405 . .

TY  - JOUR
AU  - Todosijević, Marija N.
AU  - Savić, Miroslav
AU  - Batinić, Bojan
AU  - Marković, Bojan
AU  - Gasperlin, Mirjana
AU  - Ranđelović, Danijela
AU  - Lukić, Milica
AU  - Savić, Snežana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2362
AB  - To elaborate the decisive role of surfactants in promotion of aceclofenac' skin absorption, potentially avoiding irritation, we developed non-ionic microemulsions varying natural or synthetic surfactants: sucrose esters (laurate or myristate) vs. polysorbate 80. A comprehensive physicochemical characterization indicated no significant influence of the solubilized nonsteroidal anti-inflammatory drug on the bicontinuous structure of blank formulations. To evaluate skin tolerability of isopropyl alcohol, a sucrose ester-based microemulsion containing transcutol P as a cosurfactant was also developed. The measured skin parameters strongly depended on the (co)surfactant type, showing higher compatibility of the microemulsions containing sucrose ester and isopropyl alcohol. In vitro release results, in vivo tape stripping and pharmacokinetics in rats confirmed superiority of the sucrose ester-over polysorbate-based microemulsions (total amounts of aceclofenac penetrated 60.81 +/- 5.97 and 60.86 +/- 3.67 vs. 27.00 +/- 5.09 mu g/cm(2), and its maximum plasma concentrations 275.57 +/- 109.49 and 281.31 +/- 76.76 vs. 150.23 +/- 69.74 ng/ml for sucrose laurate- and myristate- vs. polysorbate 80-based microemulsions, respectively). Hence, sugar-based excipients increased delivery of aceclofenac through stratum corneum by increasing its fluidity, showing overall more satisfying safety profiles. In conclusion, sucrose ester-based microemulsions proved to be promising carriers for dermal/transdermal aceclofenac delivery.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance
VL  - 496
IS  - 2
SP  - 931
EP  - 941
DO  - 10.1016/j.ijpharm.2015.10.048
ER  - 

@article{
author = "Todosijević, Marija N. and Savić, Miroslav and Batinić, Bojan and Marković, Bojan and Gasperlin, Mirjana and Ranđelović, Danijela and Lukić, Milica and Savić, Snežana",
year = "2015",
abstract = "To elaborate the decisive role of surfactants in promotion of aceclofenac' skin absorption, potentially avoiding irritation, we developed non-ionic microemulsions varying natural or synthetic surfactants: sucrose esters (laurate or myristate) vs. polysorbate 80. A comprehensive physicochemical characterization indicated no significant influence of the solubilized nonsteroidal anti-inflammatory drug on the bicontinuous structure of blank formulations. To evaluate skin tolerability of isopropyl alcohol, a sucrose ester-based microemulsion containing transcutol P as a cosurfactant was also developed. The measured skin parameters strongly depended on the (co)surfactant type, showing higher compatibility of the microemulsions containing sucrose ester and isopropyl alcohol. In vitro release results, in vivo tape stripping and pharmacokinetics in rats confirmed superiority of the sucrose ester-over polysorbate-based microemulsions (total amounts of aceclofenac penetrated 60.81 +/- 5.97 and 60.86 +/- 3.67 vs. 27.00 +/- 5.09 mu g/cm(2), and its maximum plasma concentrations 275.57 +/- 109.49 and 281.31 +/- 76.76 vs. 150.23 +/- 69.74 ng/ml for sucrose laurate- and myristate- vs. polysorbate 80-based microemulsions, respectively). Hence, sugar-based excipients increased delivery of aceclofenac through stratum corneum by increasing its fluidity, showing overall more satisfying safety profiles. In conclusion, sucrose ester-based microemulsions proved to be promising carriers for dermal/transdermal aceclofenac delivery.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance",
volume = "496",
number = "2",
pages = "931-941",
doi = "10.1016/j.ijpharm.2015.10.048"
}

Todosijević, M. N., Savić, M., Batinić, B., Marković, B., Gasperlin, M., Ranđelović, D., Lukić, M.,& Savić, S.. (2015). Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 496(2), 931-941.
https://doi.org/10.1016/j.ijpharm.2015.10.048

Todosijević MN, Savić M, Batinić B, Marković B, Gasperlin M, Ranđelović D, Lukić M, Savić S. Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance. in International Journal of Pharmaceutics. 2015;496(2):931-941.
doi:10.1016/j.ijpharm.2015.10.048 .

Todosijević, Marija N., Savić, Miroslav, Batinić, Bojan, Marković, Bojan, Gasperlin, Mirjana, Ranđelović, Danijela, Lukić, Milica, Savić, Snežana, "Biocompatible microemulsions of a model NSAID for skin delivery: A decisive role of surfactants in skin penetration/irritation profiles and pharmacokinetic performance" in International Journal of Pharmaceutics, 496, no. 2 (2015):931-941,
https://doi.org/10.1016/j.ijpharm.2015.10.048 . .