Mirkov, D.

Link to this page

Authority KeyName Variants
01df765a-bc56-47f2-b4db-8ef60fa270b4
  • Mirkov, D. (2)
Projects

Author's Bibliography

Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis

Roksandić Milenković, M.; Klisić, Aleksandra; Ceriman, V.; Kotur-Stevuljević, Jelena; Savić-Vujović, Katarina; Mirkov, D.; Gajić, M.; Ilić, B.; Dimić, N.; Samardžić, N.; Jovanović, D.

(Verduci Editore s.r.l, 2022)

TY  - JOUR
AU  - Roksandić Milenković, M.
AU  - Klisić, Aleksandra
AU  - Ceriman, V.
AU  - Kotur-Stevuljević, Jelena
AU  - Savić-Vujović, Katarina
AU  - Mirkov, D.
AU  - Gajić, M.
AU  - Ilić, B.
AU  - Dimić, N.
AU  - Samardžić, N.
AU  - Jovanović, D.
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4171
AB  - Objective: The pathophysiological mechanisms of idiopathic pulmonary fibrosis (IPF) are not well elucidated. It is assumed that oxidative stress and inflammation are the key underlying culprits for its onset and progression. To gain deeper insight into these processes, we have evaluated several oxidative stress parameters, inflammation markers [i.e., high sensitivity C-reactive protein (hsCRP), serum amyloid A1 (SAA1)], soluble programmed cell death-ligand 1 (sPD-L1), and 25-hydroxyvitamin D [25(OH)D] in IPF patients. Patients and Methods: Biochemistry analyses were done in 30 consecutive IPF patients and 30 age and gender-matched healthy control group (CG). Results: IPF patients had significantly higher advanced oxidation protein products (p<0.001), pro-oxidant-antioxidant balance (p=0.010), total oxidative status (p<0.001), and ischemia modified albumin (p<0.001) compared to CG. Lower total antioxidant status and total sulfhydryl groups (tSGH) and significantly higher sPD-L1, hsCRP (p<0.001 for all), SAA1 proteins (p=0.014) and [25(OH)D] severe deficiency [11.0 (9.6-15.1) nmol/L] in IPF patients compared to CG were observed. Paraoxonase 1 activity and hsCRP level were lower, while tSHG and sPD-L1 were higher in IPF patients with more severe disease (i.e., II+III stage compared to I stage, p<0.05 for all). Conclusions: IPF patients are in a state of profound oxidative stress compared to healthy people. The inflammatory component of the disease was confirmed by higher hsCRP and SAA1, but lower [25(OH)D] in IPF than in healthy people. Also, higher levels of sPD-L1 in patients with IPF compared to healthy individuals suggest that sPD-L1 may have a significant role in immune response in IPF. © 2022 Verduci Editore s.r.l. All rights reserved.
PB  - Verduci Editore s.r.l
T2  - European Review for Medical and Pharmacological Sciences
T1  - Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis
VL  - 26
IS  - 3
SP  - 927
EP  - 934
DO  - 10.26355/eurrev_202202_28002
ER  - 
@article{
author = "Roksandić Milenković, M. and Klisić, Aleksandra and Ceriman, V. and Kotur-Stevuljević, Jelena and Savić-Vujović, Katarina and Mirkov, D. and Gajić, M. and Ilić, B. and Dimić, N. and Samardžić, N. and Jovanović, D.",
year = "2022",
abstract = "Objective: The pathophysiological mechanisms of idiopathic pulmonary fibrosis (IPF) are not well elucidated. It is assumed that oxidative stress and inflammation are the key underlying culprits for its onset and progression. To gain deeper insight into these processes, we have evaluated several oxidative stress parameters, inflammation markers [i.e., high sensitivity C-reactive protein (hsCRP), serum amyloid A1 (SAA1)], soluble programmed cell death-ligand 1 (sPD-L1), and 25-hydroxyvitamin D [25(OH)D] in IPF patients. Patients and Methods: Biochemistry analyses were done in 30 consecutive IPF patients and 30 age and gender-matched healthy control group (CG). Results: IPF patients had significantly higher advanced oxidation protein products (p<0.001), pro-oxidant-antioxidant balance (p=0.010), total oxidative status (p<0.001), and ischemia modified albumin (p<0.001) compared to CG. Lower total antioxidant status and total sulfhydryl groups (tSGH) and significantly higher sPD-L1, hsCRP (p<0.001 for all), SAA1 proteins (p=0.014) and [25(OH)D] severe deficiency [11.0 (9.6-15.1) nmol/L] in IPF patients compared to CG were observed. Paraoxonase 1 activity and hsCRP level were lower, while tSHG and sPD-L1 were higher in IPF patients with more severe disease (i.e., II+III stage compared to I stage, p<0.05 for all). Conclusions: IPF patients are in a state of profound oxidative stress compared to healthy people. The inflammatory component of the disease was confirmed by higher hsCRP and SAA1, but lower [25(OH)D] in IPF than in healthy people. Also, higher levels of sPD-L1 in patients with IPF compared to healthy individuals suggest that sPD-L1 may have a significant role in immune response in IPF. © 2022 Verduci Editore s.r.l. All rights reserved.",
publisher = "Verduci Editore s.r.l",
journal = "European Review for Medical and Pharmacological Sciences",
title = "Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis",
volume = "26",
number = "3",
pages = "927-934",
doi = "10.26355/eurrev_202202_28002"
}
Roksandić Milenković, M., Klisić, A., Ceriman, V., Kotur-Stevuljević, J., Savić-Vujović, K., Mirkov, D., Gajić, M., Ilić, B., Dimić, N., Samardžić, N.,& Jovanović, D.. (2022). Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis. in European Review for Medical and Pharmacological Sciences
Verduci Editore s.r.l., 26(3), 927-934.
https://doi.org/10.26355/eurrev_202202_28002
Roksandić Milenković M, Klisić A, Ceriman V, Kotur-Stevuljević J, Savić-Vujović K, Mirkov D, Gajić M, Ilić B, Dimić N, Samardžić N, Jovanović D. Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis. in European Review for Medical and Pharmacological Sciences. 2022;26(3):927-934.
doi:10.26355/eurrev_202202_28002 .
Roksandić Milenković, M., Klisić, Aleksandra, Ceriman, V., Kotur-Stevuljević, Jelena, Savić-Vujović, Katarina, Mirkov, D., Gajić, M., Ilić, B., Dimić, N., Samardžić, N., Jovanović, D., "Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis" in European Review for Medical and Pharmacological Sciences, 26, no. 3 (2022):927-934,
https://doi.org/10.26355/eurrev_202202_28002 . .
14
14

Anthropometric, strength, endurance and flexibility characteristics of male elite ice climbers and sport climbers

Vujić, Siniša; Mirkov, D.; Dikić, N.; Küpper, Thomas; Totić, S.; Đoković, A.; Radivojević, N.; Anđelković, M.; Oblaković, B.J.; Baralić, Ivana; Manovski, K.

(Dynamic Media Sales Verlag, 2021)

TY  - JOUR
AU  - Vujić, Siniša
AU  - Mirkov, D.
AU  - Dikić, N.
AU  - Küpper, Thomas
AU  - Totić, S.
AU  - Đoković, A.
AU  - Radivojević, N.
AU  - Anđelković, M.
AU  - Oblaković, B.J.
AU  - Baralić, Ivana
AU  - Manovski, K.
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3815
AB  - Objective: Purpose of this study was to compare elite male ice climbers and sport climbers for their anthropometry, muscular strength, endurance, and flexibility. Although there is a certain overlap between these two activities, sport climbing, which recently became an Olympic discipline, has been studied significantly more than the ice climbing. Hence, the second aim was to indirectly determine whether sport climbing training processes and nutrition can be beneficial for the ice climbing athletes. › Methods: 23 male ice climbers of the Ice Climbing World Cup 2010 in Saas Fee (Switzerland) who all reached the final round were compared to 23 elite male sport climbers, which refers to “on sight” climbing grade of VII+/6b (UIAA/French) or higher. Measurements included anthropometry, three different tests for flexibility, two for strength and two for endurance. › Results: Ice climbers have more fat in the trunk region (Fat%-T), have significantly less handgrip strength in both hands, as well as strength to mass ratio (SMR) of the dominant hand. In the test “foot raise”, ice climbers showed significantly less flexibility. › Conclusion: Results indicate that ice climbers have not only higher body fat percentage, probably as an adaption to cold environment but also lower strength and flexibility than sport climbers. With such data, we can conclude that sport climbing training protocols for development of strength, endurance and flexibility can be potentially beneficial to ice climbers.
AB  - Ziel: Ziel dieser Studie war es, männliche Elite-Eisk letterer und Sportk letterer hinsichtlich ihrer Anthropometrie, Muskelkraft, Ausdauer und Flexibilität zu vergleichen. Das zweite Ziel war zu bestimmen, ob Trainingsprozesse und Ernährung auf der Grundlage  von  Untersuchungen  an  Sportk letterern  auch  für  Eiskletterer von Vorteil sein können.›Methoden: 23 männliche Eisk letterer des Ice Climbing World Cup 2010 in Saas Fee (Schweiz), die alle in die Finalrunde kamen, w urden mit 23 männlichen Elite-Sportkletterern verglichen, die „on sight“ einen K lettergrad von V II+/6b (UIA A/French) oder hö-her aufw iesen. Die Messungen umfassten die Anthropometrie, drei verschiedene Tests für Flexibilität, zwei für K raft und zwei für Ausdauer.›Ergebnisse: Eisk letterer haben mehr Fett im Rumpf bereich (Fat%-T), signifikant weniger Handgriff kraft in beiden Händen sowie Kraft-zu-Masse-Verhältnis (SMR) der dominanten Hand. Eiskletterer zeigten deutlich weniger Flexibilität imHüftbereich.›Schlussfolgerung: Die Ergebnisse zeigen, dass Eisk letterer nicht nur einen höheren Körperfettanteil haben, wahrscheinlich als Anpassung an eine kalte Umgebung, sondern auch eine gerin-gere Kraft und Flexibilität als Sportkletterer. Sportkletter-Trai-ningsprotokolle können zur Entw ick lung von Kraft, Ausdauer und Flexibilität für Eisk letterer potenziell von Vorteil sein.
PB  - Dynamic Media Sales Verlag
T2  - Deutsche Zeitschrift fur Sportmedizin
T1  - Anthropometric, strength, endurance and flexibility characteristics of male elite ice climbers and sport climbers
T1  - Anthropometrische, kraft-, ausdauer-und flexibilitätsmerkmale männlicher elite-eiskletterer und sportkletterer
VL  - 72
IS  - 2
SP  - 75
EP  - 80
DO  - 10.5960/dzsm.2020.452
ER  - 
@article{
author = "Vujić, Siniša and Mirkov, D. and Dikić, N. and Küpper, Thomas and Totić, S. and Đoković, A. and Radivojević, N. and Anđelković, M. and Oblaković, B.J. and Baralić, Ivana and Manovski, K.",
year = "2021",
abstract = "Objective: Purpose of this study was to compare elite male ice climbers and sport climbers for their anthropometry, muscular strength, endurance, and flexibility. Although there is a certain overlap between these two activities, sport climbing, which recently became an Olympic discipline, has been studied significantly more than the ice climbing. Hence, the second aim was to indirectly determine whether sport climbing training processes and nutrition can be beneficial for the ice climbing athletes. › Methods: 23 male ice climbers of the Ice Climbing World Cup 2010 in Saas Fee (Switzerland) who all reached the final round were compared to 23 elite male sport climbers, which refers to “on sight” climbing grade of VII+/6b (UIAA/French) or higher. Measurements included anthropometry, three different tests for flexibility, two for strength and two for endurance. › Results: Ice climbers have more fat in the trunk region (Fat%-T), have significantly less handgrip strength in both hands, as well as strength to mass ratio (SMR) of the dominant hand. In the test “foot raise”, ice climbers showed significantly less flexibility. › Conclusion: Results indicate that ice climbers have not only higher body fat percentage, probably as an adaption to cold environment but also lower strength and flexibility than sport climbers. With such data, we can conclude that sport climbing training protocols for development of strength, endurance and flexibility can be potentially beneficial to ice climbers., Ziel: Ziel dieser Studie war es, männliche Elite-Eisk letterer und Sportk letterer hinsichtlich ihrer Anthropometrie, Muskelkraft, Ausdauer und Flexibilität zu vergleichen. Das zweite Ziel war zu bestimmen, ob Trainingsprozesse und Ernährung auf der Grundlage  von  Untersuchungen  an  Sportk letterern  auch  für  Eiskletterer von Vorteil sein können.›Methoden: 23 männliche Eisk letterer des Ice Climbing World Cup 2010 in Saas Fee (Schweiz), die alle in die Finalrunde kamen, w urden mit 23 männlichen Elite-Sportkletterern verglichen, die „on sight“ einen K lettergrad von V II+/6b (UIA A/French) oder hö-her aufw iesen. Die Messungen umfassten die Anthropometrie, drei verschiedene Tests für Flexibilität, zwei für K raft und zwei für Ausdauer.›Ergebnisse: Eisk letterer haben mehr Fett im Rumpf bereich (Fat%-T), signifikant weniger Handgriff kraft in beiden Händen sowie Kraft-zu-Masse-Verhältnis (SMR) der dominanten Hand. Eiskletterer zeigten deutlich weniger Flexibilität imHüftbereich.›Schlussfolgerung: Die Ergebnisse zeigen, dass Eisk letterer nicht nur einen höheren Körperfettanteil haben, wahrscheinlich als Anpassung an eine kalte Umgebung, sondern auch eine gerin-gere Kraft und Flexibilität als Sportkletterer. Sportkletter-Trai-ningsprotokolle können zur Entw ick lung von Kraft, Ausdauer und Flexibilität für Eisk letterer potenziell von Vorteil sein.",
publisher = "Dynamic Media Sales Verlag",
journal = "Deutsche Zeitschrift fur Sportmedizin",
title = "Anthropometric, strength, endurance and flexibility characteristics of male elite ice climbers and sport climbers, Anthropometrische, kraft-, ausdauer-und flexibilitätsmerkmale männlicher elite-eiskletterer und sportkletterer",
volume = "72",
number = "2",
pages = "75-80",
doi = "10.5960/dzsm.2020.452"
}
Vujić, S., Mirkov, D., Dikić, N., Küpper, T., Totić, S., Đoković, A., Radivojević, N., Anđelković, M., Oblaković, B.J., Baralić, I.,& Manovski, K.. (2021). Anthropometric, strength, endurance and flexibility characteristics of male elite ice climbers and sport climbers. in Deutsche Zeitschrift fur Sportmedizin
Dynamic Media Sales Verlag., 72(2), 75-80.
https://doi.org/10.5960/dzsm.2020.452
Vujić S, Mirkov D, Dikić N, Küpper T, Totić S, Đoković A, Radivojević N, Anđelković M, Oblaković B, Baralić I, Manovski K. Anthropometric, strength, endurance and flexibility characteristics of male elite ice climbers and sport climbers. in Deutsche Zeitschrift fur Sportmedizin. 2021;72(2):75-80.
doi:10.5960/dzsm.2020.452 .
Vujić, Siniša, Mirkov, D., Dikić, N., Küpper, Thomas, Totić, S., Đoković, A., Radivojević, N., Anđelković, M., Oblaković, B.J., Baralić, Ivana, Manovski, K., "Anthropometric, strength, endurance and flexibility characteristics of male elite ice climbers and sport climbers" in Deutsche Zeitschrift fur Sportmedizin, 72, no. 2 (2021):75-80,
https://doi.org/10.5960/dzsm.2020.452 . .
1
1