TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Pavlović, Radmila
AU  - Soldatović, Ivan
AU  - Ninić, Ana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3342
AB  - Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO (OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 mu mol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R-2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD, MDA and AOPP, NOx is not associated with MetS.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Nitric oxide products are not associated with metabolic syndrome
VL  - 38
IS  - 3
SP  - 361
EP  - 367
DO  - 10.2478/jomb-2018-0035
ER  - 

@article{
author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Pavlović, Radmila and Soldatović, Ivan and Ninić, Ana",
year = "2019",
abstract = "Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO (OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 mu mol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R-2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD, MDA and AOPP, NOx is not associated with MetS.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Nitric oxide products are not associated with metabolic syndrome",
volume = "38",
number = "3",
pages = "361-367",
doi = "10.2478/jomb-2018-0035"
}

Klisić, A., Kocić, G., Kavarić, N., Pavlović, R., Soldatović, I.,& Ninić, A.. (2019). Nitric oxide products are not associated with metabolic syndrome. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(3), 361-367.
https://doi.org/10.2478/jomb-2018-0035

Klisić A, Kocić G, Kavarić N, Pavlović R, Soldatović I, Ninić A. Nitric oxide products are not associated with metabolic syndrome. in Journal of Medical Biochemistry. 2019;38(3):361-367.
doi:10.2478/jomb-2018-0035 .

Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Pavlović, Radmila, Soldatović, Ivan, Ninić, Ana, "Nitric oxide products are not associated with metabolic syndrome" in Journal of Medical Biochemistry, 38, no. 3 (2019):361-367,
https://doi.org/10.2478/jomb-2018-0035 . .