TY  - JOUR
AU  - Roksandić Milenković, M.
AU  - Klisić, Aleksandra
AU  - Ceriman, V.
AU  - Kotur-Stevuljević, Jelena
AU  - Savić-Vujović, Katarina
AU  - Mirkov, D.
AU  - Gajić, M.
AU  - Ilić, B.
AU  - Dimić, N.
AU  - Samardžić, N.
AU  - Jovanović, D.
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4171
AB  - Objective: The pathophysiological mechanisms of idiopathic pulmonary fibrosis (IPF) are not well elucidated. It is assumed that oxidative stress and inflammation are the key underlying culprits for its onset and progression. To gain deeper insight into these processes, we have evaluated several oxidative stress parameters, inflammation markers [i.e., high sensitivity C-reactive protein (hsCRP), serum amyloid A1 (SAA1)], soluble programmed cell death-ligand 1 (sPD-L1), and 25-hydroxyvitamin D [25(OH)D] in IPF patients. Patients and Methods: Biochemistry analyses were done in 30 consecutive IPF patients and 30 age and gender-matched healthy control group (CG). Results: IPF patients had significantly higher advanced oxidation protein products (p<0.001), pro-oxidant-antioxidant balance (p=0.010), total oxidative status (p<0.001), and ischemia modified albumin (p<0.001) compared to CG. Lower total antioxidant status and total sulfhydryl groups (tSGH) and significantly higher sPD-L1, hsCRP (p<0.001 for all), SAA1 proteins (p=0.014) and [25(OH)D] severe deficiency [11.0 (9.6-15.1) nmol/L] in IPF patients compared to CG were observed. Paraoxonase 1 activity and hsCRP level were lower, while tSHG and sPD-L1 were higher in IPF patients with more severe disease (i.e., II+III stage compared to I stage, p<0.05 for all). Conclusions: IPF patients are in a state of profound oxidative stress compared to healthy people. The inflammatory component of the disease was confirmed by higher hsCRP and SAA1, but lower [25(OH)D] in IPF than in healthy people. Also, higher levels of sPD-L1 in patients with IPF compared to healthy individuals suggest that sPD-L1 may have a significant role in immune response in IPF. © 2022 Verduci Editore s.r.l. All rights reserved.
PB  - Verduci Editore s.r.l
T2  - European Review for Medical and Pharmacological Sciences
T1  - Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis
VL  - 26
IS  - 3
SP  - 927
EP  - 934
DO  - 10.26355/eurrev_202202_28002
ER  - 

@article{
author = "Roksandić Milenković, M. and Klisić, Aleksandra and Ceriman, V. and Kotur-Stevuljević, Jelena and Savić-Vujović, Katarina and Mirkov, D. and Gajić, M. and Ilić, B. and Dimić, N. and Samardžić, N. and Jovanović, D.",
year = "2022",
abstract = "Objective: The pathophysiological mechanisms of idiopathic pulmonary fibrosis (IPF) are not well elucidated. It is assumed that oxidative stress and inflammation are the key underlying culprits for its onset and progression. To gain deeper insight into these processes, we have evaluated several oxidative stress parameters, inflammation markers [i.e., high sensitivity C-reactive protein (hsCRP), serum amyloid A1 (SAA1)], soluble programmed cell death-ligand 1 (sPD-L1), and 25-hydroxyvitamin D [25(OH)D] in IPF patients. Patients and Methods: Biochemistry analyses were done in 30 consecutive IPF patients and 30 age and gender-matched healthy control group (CG). Results: IPF patients had significantly higher advanced oxidation protein products (p<0.001), pro-oxidant-antioxidant balance (p=0.010), total oxidative status (p<0.001), and ischemia modified albumin (p<0.001) compared to CG. Lower total antioxidant status and total sulfhydryl groups (tSGH) and significantly higher sPD-L1, hsCRP (p<0.001 for all), SAA1 proteins (p=0.014) and [25(OH)D] severe deficiency [11.0 (9.6-15.1) nmol/L] in IPF patients compared to CG were observed. Paraoxonase 1 activity and hsCRP level were lower, while tSHG and sPD-L1 were higher in IPF patients with more severe disease (i.e., II+III stage compared to I stage, p<0.05 for all). Conclusions: IPF patients are in a state of profound oxidative stress compared to healthy people. The inflammatory component of the disease was confirmed by higher hsCRP and SAA1, but lower [25(OH)D] in IPF than in healthy people. Also, higher levels of sPD-L1 in patients with IPF compared to healthy individuals suggest that sPD-L1 may have a significant role in immune response in IPF. © 2022 Verduci Editore s.r.l. All rights reserved.",
publisher = "Verduci Editore s.r.l",
journal = "European Review for Medical and Pharmacological Sciences",
title = "Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis",
volume = "26",
number = "3",
pages = "927-934",
doi = "10.26355/eurrev_202202_28002"
}

Roksandić Milenković, M., Klisić, A., Ceriman, V., Kotur-Stevuljević, J., Savić-Vujović, K., Mirkov, D., Gajić, M., Ilić, B., Dimić, N., Samardžić, N.,& Jovanović, D.. (2022). Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis. in European Review for Medical and Pharmacological Sciences
Verduci Editore s.r.l., 26(3), 927-934.
https://doi.org/10.26355/eurrev_202202_28002

Roksandić Milenković M, Klisić A, Ceriman V, Kotur-Stevuljević J, Savić-Vujović K, Mirkov D, Gajić M, Ilić B, Dimić N, Samardžić N, Jovanović D. Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis. in European Review for Medical and Pharmacological Sciences. 2022;26(3):927-934.
doi:10.26355/eurrev_202202_28002 .

Roksandić Milenković, M., Klisić, Aleksandra, Ceriman, V., Kotur-Stevuljević, Jelena, Savić-Vujović, Katarina, Mirkov, D., Gajić, M., Ilić, B., Dimić, N., Samardžić, N., Jovanović, D., "Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis" in European Review for Medical and Pharmacological Sciences, 26, no. 3 (2022):927-934,
https://doi.org/10.26355/eurrev_202202_28002 . .

TY  - JOUR
AU  - Simić-Ogrizović, Sanja
AU  - Jovanović, D.
AU  - Dopsaj, Violeta
AU  - Radović, M.
AU  - Šumarac, Zorica
AU  - Bogavac-Stanojević, Nataša
AU  - Stošović, Milan
AU  - Stanojević, M.
AU  - Nesić, V.
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1251
AB  - The aims of the present study were to determine the prevalence of depression in our dialysis patients, to detect the most powerful variables associated with depression, and to determine the role of depression in prediction of mortality. The prospective follow-up study of 128 patients (77 HD and 51 CAPD, 65 male, aged 53.8 +/- 13.5 years, dialysis duration 64.7 +/- 64.8 months) was carried out over 3 6 months. Depression by the Beck Depression Inventory-BDI-II score, laboratory parameters (hemoglobin, serum albumin and creatinine concentration), immunological status (cytokines and hsCRP), comorbidity by Index of Physical Impairment (IPI) and adequacy of dialysis by Kt/V were monitored. The overall prevalence of depression in the dialysis patients (BDI score >= 14) was 45.3%, and 28.2%, respectively, for moderate and severe depression (BDI >= 20). The most powerful variable associated with depression was IL-6, but associations with albumin, hemoglobin, creatinine and IPI score were also found. During the follow-up period 36 patients died, 7 patients left the cohort and 2 patients were transplanted. If IPI score was not included in the multivariate Cox analysis, the BDI score remained one of the best predictors of mortality along with albumin. In conclusion, because of the close association of depression with inflammation, malnutrition, and cardiovascular mortality, it could be speculated that depression is one branch of the MIA (malnutrition, inflammation, atherosclerosis) syndrome.
PB  - Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen
T2  - Clinical Nephrology
T1  - Could depression be a new branch of MIA syndrome?
VL  - 71
IS  - 2
SP  - 164
EP  - 172
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1251
ER  - 

@article{
author = "Simić-Ogrizović, Sanja and Jovanović, D. and Dopsaj, Violeta and Radović, M. and Šumarac, Zorica and Bogavac-Stanojević, Nataša and Stošović, Milan and Stanojević, M. and Nesić, V.",
year = "2009",
abstract = "The aims of the present study were to determine the prevalence of depression in our dialysis patients, to detect the most powerful variables associated with depression, and to determine the role of depression in prediction of mortality. The prospective follow-up study of 128 patients (77 HD and 51 CAPD, 65 male, aged 53.8 +/- 13.5 years, dialysis duration 64.7 +/- 64.8 months) was carried out over 3 6 months. Depression by the Beck Depression Inventory-BDI-II score, laboratory parameters (hemoglobin, serum albumin and creatinine concentration), immunological status (cytokines and hsCRP), comorbidity by Index of Physical Impairment (IPI) and adequacy of dialysis by Kt/V were monitored. The overall prevalence of depression in the dialysis patients (BDI score >= 14) was 45.3%, and 28.2%, respectively, for moderate and severe depression (BDI >= 20). The most powerful variable associated with depression was IL-6, but associations with albumin, hemoglobin, creatinine and IPI score were also found. During the follow-up period 36 patients died, 7 patients left the cohort and 2 patients were transplanted. If IPI score was not included in the multivariate Cox analysis, the BDI score remained one of the best predictors of mortality along with albumin. In conclusion, because of the close association of depression with inflammation, malnutrition, and cardiovascular mortality, it could be speculated that depression is one branch of the MIA (malnutrition, inflammation, atherosclerosis) syndrome.",
publisher = "Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen",
journal = "Clinical Nephrology",
title = "Could depression be a new branch of MIA syndrome?",
volume = "71",
number = "2",
pages = "164-172",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1251"
}

Simić-Ogrizović, S., Jovanović, D., Dopsaj, V., Radović, M., Šumarac, Z., Bogavac-Stanojević, N., Stošović, M., Stanojević, M.,& Nesić, V.. (2009). Could depression be a new branch of MIA syndrome?. in Clinical Nephrology
Dustri-Verlag Dr Karl Feistle, Deisenhofen-Muenchen., 71(2), 164-172.
https://hdl.handle.net/21.15107/rcub_farfar_1251

Simić-Ogrizović S, Jovanović D, Dopsaj V, Radović M, Šumarac Z, Bogavac-Stanojević N, Stošović M, Stanojević M, Nesić V. Could depression be a new branch of MIA syndrome?. in Clinical Nephrology. 2009;71(2):164-172.
https://hdl.handle.net/21.15107/rcub_farfar_1251 .

Simić-Ogrizović, Sanja, Jovanović, D., Dopsaj, Violeta, Radović, M., Šumarac, Zorica, Bogavac-Stanojević, Nataša, Stošović, Milan, Stanojević, M., Nesić, V., "Could depression be a new branch of MIA syndrome?" in Clinical Nephrology, 71, no. 2 (2009):164-172,
https://hdl.handle.net/21.15107/rcub_farfar_1251 .

TY  - CONF
AU  - Vučinić, Slavica
AU  - Jovanović, D.
AU  - Antonijević, Biljana
AU  - Vučinić, Žarko
AU  - Đorđević, D.
AU  - Potrebić, O.
AU  - Rezić, T.
PY  - 2009
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1281
PB  - Informa Healthcare, New York
C3  - Clinical Toxicology
T1  - Acute Carbamate Poisoning Treated in the National Poison Control Centre During the Ten Years Period
VL  - 47
IS  - 5
SP  - 506
EP  - 507
UR  - https://hdl.handle.net/21.15107/rcub_farfar_1281
ER  - 

@conference{
author = "Vučinić, Slavica and Jovanović, D. and Antonijević, Biljana and Vučinić, Žarko and Đorđević, D. and Potrebić, O. and Rezić, T.",
year = "2009",
publisher = "Informa Healthcare, New York",
journal = "Clinical Toxicology",
title = "Acute Carbamate Poisoning Treated in the National Poison Control Centre During the Ten Years Period",
volume = "47",
number = "5",
pages = "506-507",
url = "https://hdl.handle.net/21.15107/rcub_farfar_1281"
}

Vučinić, S., Jovanović, D., Antonijević, B., Vučinić, Ž., Đorđević, D., Potrebić, O.,& Rezić, T.. (2009). Acute Carbamate Poisoning Treated in the National Poison Control Centre During the Ten Years Period. in Clinical Toxicology
Informa Healthcare, New York., 47(5), 506-507.
https://hdl.handle.net/21.15107/rcub_farfar_1281

Vučinić S, Jovanović D, Antonijević B, Vučinić Ž, Đorđević D, Potrebić O, Rezić T. Acute Carbamate Poisoning Treated in the National Poison Control Centre During the Ten Years Period. in Clinical Toxicology. 2009;47(5):506-507.
https://hdl.handle.net/21.15107/rcub_farfar_1281 .

Vučinić, Slavica, Jovanović, D., Antonijević, Biljana, Vučinić, Žarko, Đorđević, D., Potrebić, O., Rezić, T., "Acute Carbamate Poisoning Treated in the National Poison Control Centre During the Ten Years Period" in Clinical Toxicology, 47, no. 5 (2009):506-507,
https://hdl.handle.net/21.15107/rcub_farfar_1281 .

TY  - JOUR
AU  - Kovacević, I
AU  - Miljković, Branislava
AU  - Jovanović, D
AU  - Prostran, Milica
PY  - 2006
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/845
AB  - A comparison study on fluoxetine (FL) and norfluoxetine (NORFL) quantitation in human plasma was carried out between the recently developed liquid chromatographic method with fluorescence detection (LC-FLD) and an earlier established liquid chromatography-mass spectrometry (LC-MS) laboratory procedure. Comparative method evaluation was based on the analysis of plasma samples obtained from Parkinsonian patients receiving 20 mg of FL per day. The LC-FLD method involves a two-step liquid extraction procedure without any derivatization, followed by direct chromatography on a Zorbax C8 reversed-phase column. The analytical results are discussed in terms of the method validation and the corresponding experimental protocol (r >= 0.998; CV  lt  9%; LOQ 20 mu g/l). There was good correlation between FL, as well as NORFL, plasma levels as determined by the LC-MS and LC-FLD techniques (r = 0.9597, N = 16 and r = 0.9852, N = 14 for FL and NORFL, respectively). The results confirm that direct FL/NORFL fluorimetric determination is acceptable for routine use in pharmacokinetic and clinical studies.
PB  - Elsevier Science BV, Amsterdam
T2  - Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
T1  - Comparison of liquid chromatography with fluorescence detection to liquid chromatography-mass spectrometry for the determination of fluoxetine and norfluoxetine in human plasma
VL  - 830
IS  - 2
SP  - 372
EP  - 376
DO  - 10.1016/j.jchromb.2005.11.034
ER  - 

@article{
author = "Kovacević, I and Miljković, Branislava and Jovanović, D and Prostran, Milica",
year = "2006",
abstract = "A comparison study on fluoxetine (FL) and norfluoxetine (NORFL) quantitation in human plasma was carried out between the recently developed liquid chromatographic method with fluorescence detection (LC-FLD) and an earlier established liquid chromatography-mass spectrometry (LC-MS) laboratory procedure. Comparative method evaluation was based on the analysis of plasma samples obtained from Parkinsonian patients receiving 20 mg of FL per day. The LC-FLD method involves a two-step liquid extraction procedure without any derivatization, followed by direct chromatography on a Zorbax C8 reversed-phase column. The analytical results are discussed in terms of the method validation and the corresponding experimental protocol (r >= 0.998; CV  lt  9%; LOQ 20 mu g/l). There was good correlation between FL, as well as NORFL, plasma levels as determined by the LC-MS and LC-FLD techniques (r = 0.9597, N = 16 and r = 0.9852, N = 14 for FL and NORFL, respectively). The results confirm that direct FL/NORFL fluorimetric determination is acceptable for routine use in pharmacokinetic and clinical studies.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences",
title = "Comparison of liquid chromatography with fluorescence detection to liquid chromatography-mass spectrometry for the determination of fluoxetine and norfluoxetine in human plasma",
volume = "830",
number = "2",
pages = "372-376",
doi = "10.1016/j.jchromb.2005.11.034"
}

Kovacević, I., Miljković, B., Jovanović, D.,& Prostran, M.. (2006). Comparison of liquid chromatography with fluorescence detection to liquid chromatography-mass spectrometry for the determination of fluoxetine and norfluoxetine in human plasma. in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
Elsevier Science BV, Amsterdam., 830(2), 372-376.
https://doi.org/10.1016/j.jchromb.2005.11.034

Kovacević I, Miljković B, Jovanović D, Prostran M. Comparison of liquid chromatography with fluorescence detection to liquid chromatography-mass spectrometry for the determination of fluoxetine and norfluoxetine in human plasma. in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences. 2006;830(2):372-376.
doi:10.1016/j.jchromb.2005.11.034 .

Kovacević, I, Miljković, Branislava, Jovanović, D, Prostran, Milica, "Comparison of liquid chromatography with fluorescence detection to liquid chromatography-mass spectrometry for the determination of fluoxetine and norfluoxetine in human plasma" in Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences, 830, no. 2 (2006):372-376,
https://doi.org/10.1016/j.jchromb.2005.11.034 . .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Đurić, Zorica
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Kilibarda, Vesna
AU  - Jovanović, D
AU  - Kovacević, I
PY  - 2005
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/594
AB  - With the increased interest in modified release dosage forms and drug delivery systems, there is an increasing concern for biopharmaceutical characterization of the formulation in the early stages of drug product development. The main objectives of biopharmaceutical characterization are the in vitro and in vivo evaluation of the selected formulations in order to identify the factors influencing drug release; define the in vitro test methodology that would be predictive of drug products in vivo behavior and develop quantitative in vitro - in vivo correlation. The purpose of this study was to assess the potential of novel carbomer polymers, Carbopol 971P and Carbopol 71G, as a sustained release agents in matrix tablets containing high dosage drug substance. Although chemically identical, the two polymers exhibited substantially different drug release properties in vitro. Hypothetical in vivo drug release profiles were calculated by numerical deconvolution from cumulative urinary excretion data observed in vivo. The obtained results indicated that sound and reliable in vivo drug release profiles could be obtained from urinary excretion data and also, emphasized the need for in vitro testing under a range of experimental conditions in order to develop the biorelevant drug release methodology.
PB  - Springer France, Paris
T2  - European Journal of Drug Metabolism and Pharmacokinetics
T1  - Biopharmaceutical characterization of sustained release matrix tablets based on novel carbomer polymers: formulation and in vivo investigation
VL  - 30
IS  - 1-2
SP  - 99
EP  - 104
DO  - 10.1007/BF03226414
ER  - 

@article{
author = "Parojčić, Jelena and Đurić, Zorica and Jovanović, M and Ibrić, Svetlana and Kilibarda, Vesna and Jovanović, D and Kovacević, I",
year = "2005",
abstract = "With the increased interest in modified release dosage forms and drug delivery systems, there is an increasing concern for biopharmaceutical characterization of the formulation in the early stages of drug product development. The main objectives of biopharmaceutical characterization are the in vitro and in vivo evaluation of the selected formulations in order to identify the factors influencing drug release; define the in vitro test methodology that would be predictive of drug products in vivo behavior and develop quantitative in vitro - in vivo correlation. The purpose of this study was to assess the potential of novel carbomer polymers, Carbopol 971P and Carbopol 71G, as a sustained release agents in matrix tablets containing high dosage drug substance. Although chemically identical, the two polymers exhibited substantially different drug release properties in vitro. Hypothetical in vivo drug release profiles were calculated by numerical deconvolution from cumulative urinary excretion data observed in vivo. The obtained results indicated that sound and reliable in vivo drug release profiles could be obtained from urinary excretion data and also, emphasized the need for in vitro testing under a range of experimental conditions in order to develop the biorelevant drug release methodology.",
publisher = "Springer France, Paris",
journal = "European Journal of Drug Metabolism and Pharmacokinetics",
title = "Biopharmaceutical characterization of sustained release matrix tablets based on novel carbomer polymers: formulation and in vivo investigation",
volume = "30",
number = "1-2",
pages = "99-104",
doi = "10.1007/BF03226414"
}

Parojčić, J., Đurić, Z., Jovanović, M., Ibrić, S., Kilibarda, V., Jovanović, D.,& Kovacević, I.. (2005). Biopharmaceutical characterization of sustained release matrix tablets based on novel carbomer polymers: formulation and in vivo investigation. in European Journal of Drug Metabolism and Pharmacokinetics
Springer France, Paris., 30(1-2), 99-104.
https://doi.org/10.1007/BF03226414

Parojčić J, Đurić Z, Jovanović M, Ibrić S, Kilibarda V, Jovanović D, Kovacević I. Biopharmaceutical characterization of sustained release matrix tablets based on novel carbomer polymers: formulation and in vivo investigation. in European Journal of Drug Metabolism and Pharmacokinetics. 2005;30(1-2):99-104.
doi:10.1007/BF03226414 .

Parojčić, Jelena, Đurić, Zorica, Jovanović, M, Ibrić, Svetlana, Kilibarda, Vesna, Jovanović, D, Kovacević, I, "Biopharmaceutical characterization of sustained release matrix tablets based on novel carbomer polymers: formulation and in vivo investigation" in European Journal of Drug Metabolism and Pharmacokinetics, 30, no. 1-2 (2005):99-104,
https://doi.org/10.1007/BF03226414 . .

TY  - JOUR
AU  - Parojčić, Jelena
AU  - Durić, J
AU  - Jovanović, M
AU  - Ibrić, Svetlana
AU  - Jovanović, D
PY  - 2004
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/486
AB  - The influence of dissolution media composition on drug release kinetics and in-vitro/in-vivo correlation (IVIVC) for hydrophilic matrix tablets based on Carbopol 971P and Carbopol 71G was investigated. A number of buffered and unbuffered media differing with respect to their pH value, ionic strength and ionic species was evaluated. The observed in-vitro drug release profiles were compared with the hypothetical drug release profiles in-vivo calculated by numerical deconvolution from the results of an in-vivo study. The obtained IVIVC plots were examined using linear and non-linear (proportional odds, proportional hazards and proportional reversed hazards) mathematical models. Although the studied sustained release agents were chemically identical, they exhibited pronounced differences in drug product behaviour both in-vitro and in-vivo. The use of non-linear modelling resulted in an improved level of correlation, especially in the case of Carbopol 71G matrices. The obtained results indicated the susceptibility of drug release kinetics and hence IVIVC in the case of anionic polymer matrices to media composition, and emphasized the need for thorough evaluation of applied media during the development of biorelevant dissolution methodology. Although the use of non-linear modelling could be advantageous, the need for a simple and meaningful nonlinear relationship is pointed out.
PB  - Wiley, Hoboken
T2  - Journal of Pharmacy and Pharmacology
T1  - Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers
VL  - 56
IS  - 6
SP  - 735
EP  - 741
DO  - 10.1211/0022357023583
ER  - 

@article{
author = "Parojčić, Jelena and Durić, J and Jovanović, M and Ibrić, Svetlana and Jovanović, D",
year = "2004",
abstract = "The influence of dissolution media composition on drug release kinetics and in-vitro/in-vivo correlation (IVIVC) for hydrophilic matrix tablets based on Carbopol 971P and Carbopol 71G was investigated. A number of buffered and unbuffered media differing with respect to their pH value, ionic strength and ionic species was evaluated. The observed in-vitro drug release profiles were compared with the hypothetical drug release profiles in-vivo calculated by numerical deconvolution from the results of an in-vivo study. The obtained IVIVC plots were examined using linear and non-linear (proportional odds, proportional hazards and proportional reversed hazards) mathematical models. Although the studied sustained release agents were chemically identical, they exhibited pronounced differences in drug product behaviour both in-vitro and in-vivo. The use of non-linear modelling resulted in an improved level of correlation, especially in the case of Carbopol 71G matrices. The obtained results indicated the susceptibility of drug release kinetics and hence IVIVC in the case of anionic polymer matrices to media composition, and emphasized the need for thorough evaluation of applied media during the development of biorelevant dissolution methodology. Although the use of non-linear modelling could be advantageous, the need for a simple and meaningful nonlinear relationship is pointed out.",
publisher = "Wiley, Hoboken",
journal = "Journal of Pharmacy and Pharmacology",
title = "Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers",
volume = "56",
number = "6",
pages = "735-741",
doi = "10.1211/0022357023583"
}

Parojčić, J., Durić, J., Jovanović, M., Ibrić, S.,& Jovanović, D.. (2004). Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers. in Journal of Pharmacy and Pharmacology
Wiley, Hoboken., 56(6), 735-741.
https://doi.org/10.1211/0022357023583

Parojčić J, Durić J, Jovanović M, Ibrić S, Jovanović D. Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers. in Journal of Pharmacy and Pharmacology. 2004;56(6):735-741.
doi:10.1211/0022357023583 .

Parojčić, Jelena, Durić, J, Jovanović, M, Ibrić, Svetlana, Jovanović, D, "Influence of dissolution media composition on drug release and in-vitro/in-vivo correlation for paracetamol matrix tablets prepared with novel carbomer polymers" in Journal of Pharmacy and Pharmacology, 56, no. 6 (2004):735-741,
https://doi.org/10.1211/0022357023583 . .

TY  - CONF
AU  - Jovanović, D.
AU  - Ćurčić, Marijana
AU  - Nedeljković, Mirjana
PY  - 2002
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/386
PB  - Savez farmaceutskih udruženja Srbije, Beograd
C3  - Arhiv za farmaciju
T1  - Fluoride content in potable water on territory of Vranje
T1  - Sadržaj fluorida u vodi za piće na teritoriji Vranja
VL  - 52
IS  - 4
SP  - 772
EP  - 773
UR  - https://hdl.handle.net/21.15107/rcub_farfar_386
ER  - 

@conference{
author = "Jovanović, D. and Ćurčić, Marijana and Nedeljković, Mirjana",
year = "2002",
publisher = "Savez farmaceutskih udruženja Srbije, Beograd",
journal = "Arhiv za farmaciju",
title = "Fluoride content in potable water on territory of Vranje, Sadržaj fluorida u vodi za piće na teritoriji Vranja",
volume = "52",
number = "4",
pages = "772-773",
url = "https://hdl.handle.net/21.15107/rcub_farfar_386"
}

Jovanović, D., Ćurčić, M.,& Nedeljković, M.. (2002). Fluoride content in potable water on territory of Vranje. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije, Beograd., 52(4), 772-773.
https://hdl.handle.net/21.15107/rcub_farfar_386

Jovanović D, Ćurčić M, Nedeljković M. Fluoride content in potable water on territory of Vranje. in Arhiv za farmaciju. 2002;52(4):772-773.
https://hdl.handle.net/21.15107/rcub_farfar_386 .

Jovanović, D., Ćurčić, Marijana, Nedeljković, Mirjana, "Fluoride content in potable water on territory of Vranje" in Arhiv za farmaciju, 52, no. 4 (2002):772-773,
https://hdl.handle.net/21.15107/rcub_farfar_386 .