TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Jovanović, M
AU  - Stanišić, Verica
AU  - Ninić, Ana
PY  - 2020
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3142
AB  - Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity. Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained. Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = − 0.489, p < 0.001) are the independent predictors of XO activity (R2-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction. Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population. Level of Evidence: Level V: cross-sectional descriptive study.
PB  - Springer International Publishing
T2  - Eating and Weight Disorders
T1  - Body mass index is independently associated with xanthine oxidase activity in overweight/obese population
VL  - 25
IS  - 1
SP  - 9
EP  - 15
DO  - 10.1007/s40519-018-0490-5
ER  - 

@article{
author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Jovanović, M and Stanišić, Verica and Ninić, Ana",
year = "2020",
abstract = "Purpose: The pathophysiological mechanism of the relationship between xanthine oxidase (XO) activity and obesity has not been completely elucidated. Since inflammation and oxidative stress are regarded as key determinants of enlarged adipose tissue, we aimed to investigate the association between oxidative stress (as measured with XO activity), inflammation [as measured with high-sensitivity C-reactive protein (hsCRP)] and obesity [as measured with body mass index (BMI)]. In addition, we wanted to examine whether hsCRP itself plays an independent role in XO activity increase or it is only mediated through obesity. Methods: A total of 118 overweight/obese volunteers (mean age 54.76 ± 15.13 years) were included in the current cross-sectional study. Anthropometric, biochemical parameters, and blood pressure were obtained. Results: Significant differences between age, BMI, waist circumference, concentrations of uric acid and hsCRP, as well as xanthine dehydrogenase (XDH) activities were evident among XO tertile groups. Multiple linear regression analysis revealed that BMI (beta = 0.241, p = 0.012) and XDH (beta = − 0.489, p < 0.001) are the independent predictors of XO activity (R2-adjusted = 0.333), whereas hsCRP lost its independent role in XO activity prediction. Conclusion: Obesity (as determined with increased BMI) is an independent predictor of high XO activity in overweight/obese population. Level of Evidence: Level V: cross-sectional descriptive study.",
publisher = "Springer International Publishing",
journal = "Eating and Weight Disorders",
title = "Body mass index is independently associated with xanthine oxidase activity in overweight/obese population",
volume = "25",
number = "1",
pages = "9-15",
doi = "10.1007/s40519-018-0490-5"
}

Klisić, A., Kocić, G., Kavarić, N., Jovanović, M., Stanišić, V.,& Ninić, A.. (2020). Body mass index is independently associated with xanthine oxidase activity in overweight/obese population. in Eating and Weight Disorders
Springer International Publishing., 25(1), 9-15.
https://doi.org/10.1007/s40519-018-0490-5

Klisić A, Kocić G, Kavarić N, Jovanović M, Stanišić V, Ninić A. Body mass index is independently associated with xanthine oxidase activity in overweight/obese population. in Eating and Weight Disorders. 2020;25(1):9-15.
doi:10.1007/s40519-018-0490-5 .

Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Jovanović, M, Stanišić, Verica, Ninić, Ana, "Body mass index is independently associated with xanthine oxidase activity in overweight/obese population" in Eating and Weight Disorders, 25, no. 1 (2020):9-15,
https://doi.org/10.1007/s40519-018-0490-5 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Pavlović, Radmila
AU  - Soldatović, Ivan
AU  - Ninić, Ana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3342
AB  - Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO (OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 mu mol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R-2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD, MDA and AOPP, NOx is not associated with MetS.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Nitric oxide products are not associated with metabolic syndrome
VL  - 38
IS  - 3
SP  - 361
EP  - 367
DO  - 10.2478/jomb-2018-0035
ER  - 

@article{
author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Pavlović, Radmila and Soldatović, Ivan and Ninić, Ana",
year = "2019",
abstract = "Background: Nitric oxide (NO) is oxidative stress biomarker which is regarded as one of the key determinants of energy metabolism and vascular tone. Considering the controversial reports on the association between nitric oxide products (NOx) and metabolic syndrome (MetS), the aim of the current study was to examine that potential relationship. Additionally, we aimed to evaluate a broad spectrum of other oxidative stress biomarkers [i.e., malondialdehyde (MDA), advanced oxidation protein products (AOPP), xanthine oxidoreductase (XOD), xanthine oxidase (XO) xanthine dehydrogenase (XDH)] in relation with MetS. Methods: A total of 109 volunteers (46.8% of them with MetS) were included in this cross-sectional study. Biohemical and anthropometric parameters, as well as blood pressure, were obtained. The MetS was diagnosed according to the International Diabetes Federation criteria. Results: Multivariate logistic regression analysis showed that XOD (OR=1.011; 95% CI 1.002-1.019; p=0.016), XO (OR=1.014; 95% CI 1.003-1.026; p=0.016), MDA (OR=1.113; 95% CI 1.038-1.192; p=0.003) and AOPP (OR=1.022; 95% CI 1.005-1.039; p=0.012) were the independent predictors of MetS, whereas no association between NOx and MetS was found. As XOD rose for 1 U/L, XO for 1 U/L, MDA for 1 mu mol/L and AOPP for 1 T/L, probability for MetS rose for 1.1%, 1.4%, 11.3% and 2.2%, respectively. Adjusted R-2 for the Model was 0.531, which means that 53.1% of variation in MetS could be explained with this Model. Conclusions: Unlike XOD, MDA and AOPP, NOx is not associated with MetS.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Nitric oxide products are not associated with metabolic syndrome",
volume = "38",
number = "3",
pages = "361-367",
doi = "10.2478/jomb-2018-0035"
}

Klisić, A., Kocić, G., Kavarić, N., Pavlović, R., Soldatović, I.,& Ninić, A.. (2019). Nitric oxide products are not associated with metabolic syndrome. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 38(3), 361-367.
https://doi.org/10.2478/jomb-2018-0035

Klisić A, Kocić G, Kavarić N, Pavlović R, Soldatović I, Ninić A. Nitric oxide products are not associated with metabolic syndrome. in Journal of Medical Biochemistry. 2019;38(3):361-367.
doi:10.2478/jomb-2018-0035 .

Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Pavlović, Radmila, Soldatović, Ivan, Ninić, Ana, "Nitric oxide products are not associated with metabolic syndrome" in Journal of Medical Biochemistry, 38, no. 3 (2019):361-367,
https://doi.org/10.2478/jomb-2018-0035 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Abenavoli, Ludovico
AU  - Fagoonee, Sharmila
AU  - Kavarić, Nebojša
AU  - Kocić, Gordana
AU  - Ninić, Ana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3302
AB  - BACKGROUND: It is known that non-alcoholic fatty liver disease (NAFLD), and in particular non-alcoholic steatohepatitis, can progress to advanced fibrosis. However, pathophysiological mechanisms implicated in this evolution are not elucidated yet. We aimed to investigate the independent predictors of liver fibrosis in patients with NAFLD, determined by BARD score, one of the most used algorithms for fibrosis evaluation. METHODS: This prospective study enrolled a total of 301 participants with NAFLD, as determined by a Fatty Liver Index (FLI) >= 60. All patients were categorized into two groups: with no/mild fibrosis (BARD score 1, N.=62) and with advanced fibrosis (BARD score 2, 3 and 4 N.=239). RESULTS: Serum high density lipoprotein cholesterol (HDL-c), glucose and glycated hemoglobin were higher (P=0.028, P lt 0.001 and P=0.002, respectively), whereas serum transaminases and gamma glutamil transferase levels were lower in patients with advanced fibrosis than in those with no/ mild fibrosis (P=0.010, P lt 0.001 and P=0.005, respectively). There were no significant differences in oxidative stress (i.e., advanced oxidant protein products and malondialdehyde) and anti-oxidative protection markers (i.e., catalase) between patients with no/ mild fibrosis and advanced fibrosis. Multivariate ordinal regression analysis showed independent associations and predictions of ages (OR=1.071, 95% CI 1.004-1.097, P lt 0.001), and HDL-c levels (OR= 2.549, 95% CI 1.087-5.989, P=0.032) on BARD score categories in patients with NAFLD. CONCLUSIONS: In conclusion, we found that older age and higher HDL-c, are independent predictors for advanced liver fibrosis assessed with the BARD score. Future investigations are needed to further explore this relationship.
PB  - Edizioni Minerva Medica, Turin
T2  - Minerva Medica
T1  - Older age and HDL-cholesterol as independent predictors of liver fibrosis assessed by BARD score
VL  - 110
IS  - 3
SP  - 191
EP  - 198
DO  - 10.23736/S0026-4806.19.05978-0
ER  - 

@article{
author = "Klisić, Aleksandra and Abenavoli, Ludovico and Fagoonee, Sharmila and Kavarić, Nebojša and Kocić, Gordana and Ninić, Ana",
year = "2019",
abstract = "BACKGROUND: It is known that non-alcoholic fatty liver disease (NAFLD), and in particular non-alcoholic steatohepatitis, can progress to advanced fibrosis. However, pathophysiological mechanisms implicated in this evolution are not elucidated yet. We aimed to investigate the independent predictors of liver fibrosis in patients with NAFLD, determined by BARD score, one of the most used algorithms for fibrosis evaluation. METHODS: This prospective study enrolled a total of 301 participants with NAFLD, as determined by a Fatty Liver Index (FLI) >= 60. All patients were categorized into two groups: with no/mild fibrosis (BARD score 1, N.=62) and with advanced fibrosis (BARD score 2, 3 and 4 N.=239). RESULTS: Serum high density lipoprotein cholesterol (HDL-c), glucose and glycated hemoglobin were higher (P=0.028, P lt 0.001 and P=0.002, respectively), whereas serum transaminases and gamma glutamil transferase levels were lower in patients with advanced fibrosis than in those with no/ mild fibrosis (P=0.010, P lt 0.001 and P=0.005, respectively). There were no significant differences in oxidative stress (i.e., advanced oxidant protein products and malondialdehyde) and anti-oxidative protection markers (i.e., catalase) between patients with no/ mild fibrosis and advanced fibrosis. Multivariate ordinal regression analysis showed independent associations and predictions of ages (OR=1.071, 95% CI 1.004-1.097, P lt 0.001), and HDL-c levels (OR= 2.549, 95% CI 1.087-5.989, P=0.032) on BARD score categories in patients with NAFLD. CONCLUSIONS: In conclusion, we found that older age and higher HDL-c, are independent predictors for advanced liver fibrosis assessed with the BARD score. Future investigations are needed to further explore this relationship.",
publisher = "Edizioni Minerva Medica, Turin",
journal = "Minerva Medica",
title = "Older age and HDL-cholesterol as independent predictors of liver fibrosis assessed by BARD score",
volume = "110",
number = "3",
pages = "191-198",
doi = "10.23736/S0026-4806.19.05978-0"
}

Klisić, A., Abenavoli, L., Fagoonee, S., Kavarić, N., Kocić, G.,& Ninić, A.. (2019). Older age and HDL-cholesterol as independent predictors of liver fibrosis assessed by BARD score. in Minerva Medica
Edizioni Minerva Medica, Turin., 110(3), 191-198.
https://doi.org/10.23736/S0026-4806.19.05978-0

Klisić A, Abenavoli L, Fagoonee S, Kavarić N, Kocić G, Ninić A. Older age and HDL-cholesterol as independent predictors of liver fibrosis assessed by BARD score. in Minerva Medica. 2019;110(3):191-198.
doi:10.23736/S0026-4806.19.05978-0 .

Klisić, Aleksandra, Abenavoli, Ludovico, Fagoonee, Sharmila, Kavarić, Nebojša, Kocić, Gordana, Ninić, Ana, "Older age and HDL-cholesterol as independent predictors of liver fibrosis assessed by BARD score" in Minerva Medica, 110, no. 3 (2019):191-198,
https://doi.org/10.23736/S0026-4806.19.05978-0 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Isaković, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Zvrko, Elvir
AU  - Skerović, Verica
AU  - Ninić, Ana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3233
AB  - Introduction/Aim Considering the high prevalence of nonalcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate the potential benefit of determining markers of oxidative stress, inflammation and dyslipidemia for prediction of NAFLD, as estimated with fatty liver index (FLI) in individuals with DM2. Methods A total of 139 individuals with DM2 (of them 49.9 % females) were enrolled in cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure were obtained. A FLI was calculated. Results Multivariate logistic regression analysis showed that high density lipoprotein cholesterol (HDL-c) and malondialdehyde (MDA) were independent predictors of higher FLI [Odds ratio (OR) = 0.056, p = 0.029; and OR = 1.105, p = 0.016, respectively]. In Receiver Operating Characteristic curve analysis, the addition of fatty liver risk factors (e.g., age, gender, body height, smoking status, diabetes duration and drugs metabolized in liver) to each analysed biochemical parameter [HDL-c, non-HDL-c, high sensitivity C-reactive protein (hsCRP), MDA and advanced oxidant protein products (AOPP)] in Model 1, increased the ability to discriminate patients with and without fatty liver [Area under the curve (AUC) = 0.832, AUC = 0.808, AUC = 0.798, AUC = 0.824 and AUC = 0.743, respectively]. Model 2 (which included all five examined predictors, e.g., HDL-c, non-HDL-c, hsCRP, MDA, AOPP, and fatty liver risk factors) improved discriminative abilities for fatty liver status (AUC = 0.909). Even more, Model 2 had the highest sensitivity and specificity (89.3 % and 87.5 %, respectively) together than each predictor in Model 1. Conclusion Multimarker approach, including biomarkers of oxidative stress, dyslipidemia and inflammation, could be of benefit in identifying patients with diabetes being at high risk of fatty liver disease.
PB  - Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart
T2  - Experimental and Clinical Endocrinology & Diabetes
T1  - Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus
VL  - 126
IS  - 6
SP  - 371
EP  - 378
DO  - 10.1055/s-0043-118667
ER  - 

@article{
author = "Klisić, Aleksandra and Isaković, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Jovanović, Milovan and Zvrko, Elvir and Skerović, Verica and Ninić, Ana",
year = "2018",
abstract = "Introduction/Aim Considering the high prevalence of nonalcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate the potential benefit of determining markers of oxidative stress, inflammation and dyslipidemia for prediction of NAFLD, as estimated with fatty liver index (FLI) in individuals with DM2. Methods A total of 139 individuals with DM2 (of them 49.9 % females) were enrolled in cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure were obtained. A FLI was calculated. Results Multivariate logistic regression analysis showed that high density lipoprotein cholesterol (HDL-c) and malondialdehyde (MDA) were independent predictors of higher FLI [Odds ratio (OR) = 0.056, p = 0.029; and OR = 1.105, p = 0.016, respectively]. In Receiver Operating Characteristic curve analysis, the addition of fatty liver risk factors (e.g., age, gender, body height, smoking status, diabetes duration and drugs metabolized in liver) to each analysed biochemical parameter [HDL-c, non-HDL-c, high sensitivity C-reactive protein (hsCRP), MDA and advanced oxidant protein products (AOPP)] in Model 1, increased the ability to discriminate patients with and without fatty liver [Area under the curve (AUC) = 0.832, AUC = 0.808, AUC = 0.798, AUC = 0.824 and AUC = 0.743, respectively]. Model 2 (which included all five examined predictors, e.g., HDL-c, non-HDL-c, hsCRP, MDA, AOPP, and fatty liver risk factors) improved discriminative abilities for fatty liver status (AUC = 0.909). Even more, Model 2 had the highest sensitivity and specificity (89.3 % and 87.5 %, respectively) together than each predictor in Model 1. Conclusion Multimarker approach, including biomarkers of oxidative stress, dyslipidemia and inflammation, could be of benefit in identifying patients with diabetes being at high risk of fatty liver disease.",
publisher = "Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart",
journal = "Experimental and Clinical Endocrinology & Diabetes",
title = "Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus",
volume = "126",
number = "6",
pages = "371-378",
doi = "10.1055/s-0043-118667"
}

Klisić, A., Isaković, A., Kocić, G., Kavarić, N., Jovanović, M., Zvrko, E., Skerović, V.,& Ninić, A.. (2018). Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus. in Experimental and Clinical Endocrinology & Diabetes
Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart., 126(6), 371-378.
https://doi.org/10.1055/s-0043-118667

Klisić A, Isaković A, Kocić G, Kavarić N, Jovanović M, Zvrko E, Skerović V, Ninić A. Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus. in Experimental and Clinical Endocrinology & Diabetes. 2018;126(6):371-378.
doi:10.1055/s-0043-118667 .

Klisić, Aleksandra, Isaković, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Jovanović, Milovan, Zvrko, Elvir, Skerović, Verica, Ninić, Ana, "Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus" in Experimental and Clinical Endocrinology & Diabetes, 126, no. 6 (2018):371-378,
https://doi.org/10.1055/s-0043-118667 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Stanišić, Verica
AU  - Ninić, Ana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3161
AB  - Xanthine oxidase (XO) is an important enzyme responsible for conversion of purine bases to uric acid and represents the major source of reactive oxygen species (ROS) production in circulation. Since pathophysiological mechanism of the relationship between XO activity and urinary albumin excretion (UAE) rate is not well elucidated, we aimed to investigate this association in patients with diabetes mellitus type 2 (DM2). In addition, we wanted to examine whether uric acid itself plays an independent role in albuminuria onset and progression, or it is only mediated through XO activity. A total of 83 patients with DM2 (of them 56.6% females) were included in this cross-sectional study. Anthropometric, biochemical parameters and blood pressure were obtained. Multivariate logistic regression analysis showed that uric acid and XO were the independent predictors for albuminuria onset in patients with DM2 [odds ratio (OR) 1.015, 95% CI (1.008-1.028), p = 0.026 and OR 1.015, 95% CI (1.006-1.026), p = 0.040, respectively]. Rise in uric acid for 1 mu mol/L enhanced the probability for albuminuria by 1.5%. Also, elevation in XO activity for 1 U/L increased the probability for albuminuria for 1.5%. A total of 66.7% of variation in UAE could be explained with this Model. Both XO and uric acid are independently associated with albuminuria in diabetes. Better understanding of pathophysiological relationship between oxidative stress and albuminuria could lead to discoveries of best pharmacological treatment of XO- and/or uric acid-induced ROS, in order to prevent albuminuria onset and progression.
PB  - Springer-Verlag Italia Srl, Milan
T2  - Clinical and Experimental Medicine
T1  - Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2
VL  - 18
IS  - 2
SP  - 283
EP  - 290
DO  - 10.1007/s10238-017-0483-0
ER  - 

@article{
author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Jovanović, Milovan and Stanišić, Verica and Ninić, Ana",
year = "2018",
abstract = "Xanthine oxidase (XO) is an important enzyme responsible for conversion of purine bases to uric acid and represents the major source of reactive oxygen species (ROS) production in circulation. Since pathophysiological mechanism of the relationship between XO activity and urinary albumin excretion (UAE) rate is not well elucidated, we aimed to investigate this association in patients with diabetes mellitus type 2 (DM2). In addition, we wanted to examine whether uric acid itself plays an independent role in albuminuria onset and progression, or it is only mediated through XO activity. A total of 83 patients with DM2 (of them 56.6% females) were included in this cross-sectional study. Anthropometric, biochemical parameters and blood pressure were obtained. Multivariate logistic regression analysis showed that uric acid and XO were the independent predictors for albuminuria onset in patients with DM2 [odds ratio (OR) 1.015, 95% CI (1.008-1.028), p = 0.026 and OR 1.015, 95% CI (1.006-1.026), p = 0.040, respectively]. Rise in uric acid for 1 mu mol/L enhanced the probability for albuminuria by 1.5%. Also, elevation in XO activity for 1 U/L increased the probability for albuminuria for 1.5%. A total of 66.7% of variation in UAE could be explained with this Model. Both XO and uric acid are independently associated with albuminuria in diabetes. Better understanding of pathophysiological relationship between oxidative stress and albuminuria could lead to discoveries of best pharmacological treatment of XO- and/or uric acid-induced ROS, in order to prevent albuminuria onset and progression.",
publisher = "Springer-Verlag Italia Srl, Milan",
journal = "Clinical and Experimental Medicine",
title = "Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2",
volume = "18",
number = "2",
pages = "283-290",
doi = "10.1007/s10238-017-0483-0"
}

Klisić, A., Kocić, G., Kavarić, N., Jovanović, M., Stanišić, V.,& Ninić, A.. (2018). Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2. in Clinical and Experimental Medicine
Springer-Verlag Italia Srl, Milan., 18(2), 283-290.
https://doi.org/10.1007/s10238-017-0483-0

Klisić A, Kocić G, Kavarić N, Jovanović M, Stanišić V, Ninić A. Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2. in Clinical and Experimental Medicine. 2018;18(2):283-290.
doi:10.1007/s10238-017-0483-0 .

Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Jovanović, Milovan, Stanišić, Verica, Ninić, Ana, "Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2" in Clinical and Experimental Medicine, 18, no. 2 (2018):283-290,
https://doi.org/10.1007/s10238-017-0483-0 . .