TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Bjelaković, Bojko
AU  - Jovanović, Milovan
AU  - Zvrko, Elvir
AU  - Stanišić, Verica
AU  - Ninić, Ana
AU  - Šćepanović, Anđelka
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3239
AB  - Reynolds Risk Score (RRS) is regarded as a good screening tool for cardiovascular disease (CVD) risk. Since CVD is the leading cause of death in Montenegro, we aimed to assess the risk of CVD as assessed by RRS and to examine its association with cardiometabolic parameters in apparently healthy middle-aged population. In addition, we aimed to test whether obesity had an independent influence on RRS. A total of 132 participants (mean age 56.2 +/- 6.73 years, 69% females) were included. Body mass index (BMI), waist circumference (WC), blood pressure (BP) and biochemical parameters (fasting glucose, insulin, lipid parameters, creatinine and high sensitivity C-reactive protein) were determined. Insulin resistance (HOMA-IR) and glomerular filtration rate (eGFR) were calculated. Compared with females, a significantly higher number of males were in the high RRS subgroup (chi(2) =45.9, p lt 0.001). Furthermore, significantly higher fasting glucose (p=0.030), insulin, HOMA-IR, triglycerides (p lt 0.001 all), anthropometric parameters (e.g., BMI and WC; p=0.004 and p lt 0.001, respectively), and creatinine, but lower eGFR and HDL-c (p lt 0.001 both) were recorded in the high-risk subgroup compared with low and medium risk subgroups. In all participants, in addition to LDL-c, diastolic BP and creatinine, WC was independently positively associated with RRS (beta=0.194, p=0.006; lt b> beta=0186, p=0.001; beta=0167, p=0.001; and beta=0.305, p=0.019, respectively), and 40% of variation in RRS could be explained with this model. In conclusion, middle-aged population with higher WC should be screened for RRS in order to estimate CVD risk.
PB  - Sestre Milosrdnice Univ Hospital, Zagreb
T2  - Acta Clinica Croatica
T1  - Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro
VL  - 57
IS  - 1
SP  - 22
EP  - 30
DO  - 10.20471/acc.2018.57.01.03
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Bjelaković, Bojko and Jovanović, Milovan and Zvrko, Elvir and Stanišić, Verica and Ninić, Ana and Šćepanović, Anđelka",
year = "2018",
abstract = "Reynolds Risk Score (RRS) is regarded as a good screening tool for cardiovascular disease (CVD) risk. Since CVD is the leading cause of death in Montenegro, we aimed to assess the risk of CVD as assessed by RRS and to examine its association with cardiometabolic parameters in apparently healthy middle-aged population. In addition, we aimed to test whether obesity had an independent influence on RRS. A total of 132 participants (mean age 56.2 +/- 6.73 years, 69% females) were included. Body mass index (BMI), waist circumference (WC), blood pressure (BP) and biochemical parameters (fasting glucose, insulin, lipid parameters, creatinine and high sensitivity C-reactive protein) were determined. Insulin resistance (HOMA-IR) and glomerular filtration rate (eGFR) were calculated. Compared with females, a significantly higher number of males were in the high RRS subgroup (chi(2) =45.9, p lt 0.001). Furthermore, significantly higher fasting glucose (p=0.030), insulin, HOMA-IR, triglycerides (p lt 0.001 all), anthropometric parameters (e.g., BMI and WC; p=0.004 and p lt 0.001, respectively), and creatinine, but lower eGFR and HDL-c (p lt 0.001 both) were recorded in the high-risk subgroup compared with low and medium risk subgroups. In all participants, in addition to LDL-c, diastolic BP and creatinine, WC was independently positively associated with RRS (beta=0.194, p=0.006; lt b> beta=0186, p=0.001; beta=0167, p=0.001; and beta=0.305, p=0.019, respectively), and 40% of variation in RRS could be explained with this model. In conclusion, middle-aged population with higher WC should be screened for RRS in order to estimate CVD risk.",
publisher = "Sestre Milosrdnice Univ Hospital, Zagreb",
journal = "Acta Clinica Croatica",
title = "Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro",
volume = "57",
number = "1",
pages = "22-30",
doi = "10.20471/acc.2018.57.01.03"
}

Klisić, A., Kavarić, N., Bjelaković, B., Jovanović, M., Zvrko, E., Stanišić, V., Ninić, A.,& Šćepanović, A.. (2018). Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro. in Acta Clinica Croatica
Sestre Milosrdnice Univ Hospital, Zagreb., 57(1), 22-30.
https://doi.org/10.20471/acc.2018.57.01.03

Klisić A, Kavarić N, Bjelaković B, Jovanović M, Zvrko E, Stanišić V, Ninić A, Šćepanović A. Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro. in Acta Clinica Croatica. 2018;57(1):22-30.
doi:10.20471/acc.2018.57.01.03 .

Klisić, Aleksandra, Kavarić, Nebojša, Bjelaković, Bojko, Jovanović, Milovan, Zvrko, Elvir, Stanišić, Verica, Ninić, Ana, Šćepanović, Anđelka, "Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro" in Acta Clinica Croatica, 57, no. 1 (2018):22-30,
https://doi.org/10.20471/acc.2018.57.01.03 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Bjelaković, Bojko
AU  - Zvrko, Elvir
AU  - Soldatović, Ivan
AU  - Kotur-Stevuljević, Jelena
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3120
AB  - Objective: Better than simple anthropometric parameters, the visceral adiposity index (VAI) has recently been proposed as a predictor of cardiometabolic risk in adults. However, there are conflicting results on the associations of these parameters in children and adolescents. Therefore, we aimed to estimate this potential relationship between VAI, anthropometric parameters (i.e., body mass index [BMI], waist circumference [WC], and waist-to-height ratio [WHtR], respectively), and inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) levels in a cohort of adolescent girls. Methods: A total of 90 adolescent girls from 16 to 19 years old were included in cross-sectional study. Anthropometric and biochemical parameters (glucose, lipid parameters, and hsCRP) were measured. The VAI, derived from anthropometric and lipid parameters, calculated {[WC/36.58 + (1.89 x BMI)] x (triglycerides/0.81) x (1.52/ HDL-cholesterol)} was calculated. Results: A comparison of the receiver operating characteristic (ROC) curves showed that all the curves for the anthropometric parameters (e.g., BMI, WC, WHtR) had excellent discriminatory capability with regard to inflammation level status (low vs. high level) and significantly larger areas under the curve (AUC = 0.885, AUC = 0.863, AUC = 0.860, respectively; P lt 0.001) than the ROC curve for VAI did (AUC = 0.686; P = 0.021). Conclusion: Visceral adiposity index is not superior over anthropometric parameters in relation to inflammation as measured by high sensitivity C-reactive protein in adolescent girls.
PB  - Univ Puerto Rico Medical Sciences Campus, San Juan
T2  - Puerto Rico Health Sciences Journal
T1  - Visceral Adiposity Index is not Superior over Anthropometric Parameters with regards to Inflammation in Healthy Adolescent Girls
VL  - 37
IS  - 4
SP  - 195
EP  - 199
UR  - https://hdl.handle.net/21.15107/rcub_farfar_3120
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Bjelaković, Bojko and Zvrko, Elvir and Soldatović, Ivan and Kotur-Stevuljević, Jelena",
year = "2018",
abstract = "Objective: Better than simple anthropometric parameters, the visceral adiposity index (VAI) has recently been proposed as a predictor of cardiometabolic risk in adults. However, there are conflicting results on the associations of these parameters in children and adolescents. Therefore, we aimed to estimate this potential relationship between VAI, anthropometric parameters (i.e., body mass index [BMI], waist circumference [WC], and waist-to-height ratio [WHtR], respectively), and inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) levels in a cohort of adolescent girls. Methods: A total of 90 adolescent girls from 16 to 19 years old were included in cross-sectional study. Anthropometric and biochemical parameters (glucose, lipid parameters, and hsCRP) were measured. The VAI, derived from anthropometric and lipid parameters, calculated {[WC/36.58 + (1.89 x BMI)] x (triglycerides/0.81) x (1.52/ HDL-cholesterol)} was calculated. Results: A comparison of the receiver operating characteristic (ROC) curves showed that all the curves for the anthropometric parameters (e.g., BMI, WC, WHtR) had excellent discriminatory capability with regard to inflammation level status (low vs. high level) and significantly larger areas under the curve (AUC = 0.885, AUC = 0.863, AUC = 0.860, respectively; P lt 0.001) than the ROC curve for VAI did (AUC = 0.686; P = 0.021). Conclusion: Visceral adiposity index is not superior over anthropometric parameters in relation to inflammation as measured by high sensitivity C-reactive protein in adolescent girls.",
publisher = "Univ Puerto Rico Medical Sciences Campus, San Juan",
journal = "Puerto Rico Health Sciences Journal",
title = "Visceral Adiposity Index is not Superior over Anthropometric Parameters with regards to Inflammation in Healthy Adolescent Girls",
volume = "37",
number = "4",
pages = "195-199",
url = "https://hdl.handle.net/21.15107/rcub_farfar_3120"
}

Klisić, A., Kavarić, N., Bjelaković, B., Zvrko, E., Soldatović, I.,& Kotur-Stevuljević, J.. (2018). Visceral Adiposity Index is not Superior over Anthropometric Parameters with regards to Inflammation in Healthy Adolescent Girls. in Puerto Rico Health Sciences Journal
Univ Puerto Rico Medical Sciences Campus, San Juan., 37(4), 195-199.
https://hdl.handle.net/21.15107/rcub_farfar_3120

Klisić A, Kavarić N, Bjelaković B, Zvrko E, Soldatović I, Kotur-Stevuljević J. Visceral Adiposity Index is not Superior over Anthropometric Parameters with regards to Inflammation in Healthy Adolescent Girls. in Puerto Rico Health Sciences Journal. 2018;37(4):195-199.
https://hdl.handle.net/21.15107/rcub_farfar_3120 .

Klisić, Aleksandra, Kavarić, Nebojša, Bjelaković, Bojko, Zvrko, Elvir, Soldatović, Ivan, Kotur-Stevuljević, Jelena, "Visceral Adiposity Index is not Superior over Anthropometric Parameters with regards to Inflammation in Healthy Adolescent Girls" in Puerto Rico Health Sciences Journal, 37, no. 4 (2018):195-199,
https://hdl.handle.net/21.15107/rcub_farfar_3120 .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Bjelaković, Bojko
AU  - Soldatović, Ivan
AU  - Martinović, Milica
AU  - Kotur-Stevuljević, Jelena
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3017
AB  - Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge, there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Therefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6 +/- 1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e.g., sex, high-density lipoprotein cholesterol (HDL-c), non-HDL-c, smoking, blood pressure and fasting glycemia). According to the risk status, we divided adolescent girls into low, medium and high risk groups (-2  lt = CVRS  lt = 1, 2  lt = CVRS 54 and CVRS >= 5, respectively). We found significantly higher RBP4 in the high risk group as compared with low risk group (p lt 0.001). However, multiple linear regression analysis showed waist circumference (beta=0.257, p=0.031) to be the only independent predictor of higher cardiovascular risk (adjusted R'=0.342, p lt 0.001). In conclusion, RBP4 may be associated with higher cardiovascular risk in overweight/obese adolescent girls, but this association is mediated by abdominal obesity.
PB  - Sestre Milosrdnice Univ Hospital, Zagreb
T2  - Acta Clinica Croatica
T1  - The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls
VL  - 56
IS  - 1
SP  - 92
EP  - 98
DO  - 10.20471/acc.2017.56.01.14
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Bjelaković, Bojko and Soldatović, Ivan and Martinović, Milica and Kotur-Stevuljević, Jelena",
year = "2017",
abstract = "Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge, there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Therefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6 +/- 1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e.g., sex, high-density lipoprotein cholesterol (HDL-c), non-HDL-c, smoking, blood pressure and fasting glycemia). According to the risk status, we divided adolescent girls into low, medium and high risk groups (-2  lt = CVRS  lt = 1, 2  lt = CVRS 54 and CVRS >= 5, respectively). We found significantly higher RBP4 in the high risk group as compared with low risk group (p lt 0.001). However, multiple linear regression analysis showed waist circumference (beta=0.257, p=0.031) to be the only independent predictor of higher cardiovascular risk (adjusted R'=0.342, p lt 0.001). In conclusion, RBP4 may be associated with higher cardiovascular risk in overweight/obese adolescent girls, but this association is mediated by abdominal obesity.",
publisher = "Sestre Milosrdnice Univ Hospital, Zagreb",
journal = "Acta Clinica Croatica",
title = "The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls",
volume = "56",
number = "1",
pages = "92-98",
doi = "10.20471/acc.2017.56.01.14"
}

Klisić, A., Kavarić, N., Bjelaković, B., Soldatović, I., Martinović, M.,& Kotur-Stevuljević, J.. (2017). The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls. in Acta Clinica Croatica
Sestre Milosrdnice Univ Hospital, Zagreb., 56(1), 92-98.
https://doi.org/10.20471/acc.2017.56.01.14

Klisić A, Kavarić N, Bjelaković B, Soldatović I, Martinović M, Kotur-Stevuljević J. The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls. in Acta Clinica Croatica. 2017;56(1):92-98.
doi:10.20471/acc.2017.56.01.14 .

Klisić, Aleksandra, Kavarić, Nebojša, Bjelaković, Bojko, Soldatović, Ivan, Martinović, Milica, Kotur-Stevuljević, Jelena, "The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls" in Acta Clinica Croatica, 56, no. 1 (2017):92-98,
https://doi.org/10.20471/acc.2017.56.01.14 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Soldatović, Ivan
AU  - Bjelaković, Bojko
AU  - Kotur-Stevuljević, Jelena
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2661
AB  - Background: Since the cardiovascular (CV) risk score in the young population, children and adolescents, is underestimated, especially in developing countries such as Montenegro, where a strong interaction exists between the genetically conditioned CV risk and environmental factors, the purpose of this study was to estimate CV risk in apparently healthy adolescent girls. Moreover, we aimed to test some new, emerging CV risk factors and their interaction with the traditional ones, such as obesity. Precisely, we aimed to assess the impact of low bilirubin levels, as a routine biochemical parameter, as an additional risk factor for atherosclerotic disease in the adult phase. Methods: Forty-five obese adolescent girls (mean age 17.8 +/- 1.22 years) and forty-five age-and sex-matched normal weight controls, all nonsmokers, were included. Anthropometric and biochemical parameters were measured. Cardiovascular Risk Score (CVRS) was calculated by adding the points for each risk factor (e.g. sex, HDL-c, non-HDLc, blood pressure and fasting glycemia). Results: A significant positive relationship between CVRS and ALT, hsCRP and TG/HDL-c, but an opposite relationship between CVRS and total bilirubin were found (P lt 0.001). Multiple linear regression analysis showed that higher waist circumference (WC) and LDL-c, but lower HDL-c were independent predictors of lower bilirubin values (adjusted R-2=0.603, P lt 0.001). Conclusions: Obese adolescent girls are at an increased risk of cardiovascular disease late in life. In addition to the traditional risk factors, total bilirubin may have the potential to discriminate between low and higher risk for cardiovascular disturbances in healthy adolescent girls.
PB  - Društvo medicinskih biohemičara Srbije, Beograd i Versita
T2  - Journal of Medical Biochemistry
T1  - Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls
VL  - 35
IS  - 3
SP  - 282
EP  - 292
DO  - 10.1515/jomb-2016-0005
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Soldatović, Ivan and Bjelaković, Bojko and Kotur-Stevuljević, Jelena",
year = "2016",
abstract = "Background: Since the cardiovascular (CV) risk score in the young population, children and adolescents, is underestimated, especially in developing countries such as Montenegro, where a strong interaction exists between the genetically conditioned CV risk and environmental factors, the purpose of this study was to estimate CV risk in apparently healthy adolescent girls. Moreover, we aimed to test some new, emerging CV risk factors and their interaction with the traditional ones, such as obesity. Precisely, we aimed to assess the impact of low bilirubin levels, as a routine biochemical parameter, as an additional risk factor for atherosclerotic disease in the adult phase. Methods: Forty-five obese adolescent girls (mean age 17.8 +/- 1.22 years) and forty-five age-and sex-matched normal weight controls, all nonsmokers, were included. Anthropometric and biochemical parameters were measured. Cardiovascular Risk Score (CVRS) was calculated by adding the points for each risk factor (e.g. sex, HDL-c, non-HDLc, blood pressure and fasting glycemia). Results: A significant positive relationship between CVRS and ALT, hsCRP and TG/HDL-c, but an opposite relationship between CVRS and total bilirubin were found (P lt 0.001). Multiple linear regression analysis showed that higher waist circumference (WC) and LDL-c, but lower HDL-c were independent predictors of lower bilirubin values (adjusted R-2=0.603, P lt 0.001). Conclusions: Obese adolescent girls are at an increased risk of cardiovascular disease late in life. In addition to the traditional risk factors, total bilirubin may have the potential to discriminate between low and higher risk for cardiovascular disturbances in healthy adolescent girls.",
publisher = "Društvo medicinskih biohemičara Srbije, Beograd i Versita",
journal = "Journal of Medical Biochemistry",
title = "Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls",
volume = "35",
number = "3",
pages = "282-292",
doi = "10.1515/jomb-2016-0005"
}

Klisić, A., Kavarić, N., Soldatović, I., Bjelaković, B.,& Kotur-Stevuljević, J.. (2016). Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls. in Journal of Medical Biochemistry
Društvo medicinskih biohemičara Srbije, Beograd i Versita., 35(3), 282-292.
https://doi.org/10.1515/jomb-2016-0005

Klisić A, Kavarić N, Soldatović I, Bjelaković B, Kotur-Stevuljević J. Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls. in Journal of Medical Biochemistry. 2016;35(3):282-292.
doi:10.1515/jomb-2016-0005 .

Klisić, Aleksandra, Kavarić, Nebojša, Soldatović, Ivan, Bjelaković, Bojko, Kotur-Stevuljević, Jelena, "Relationship between cardiovascular risk score and traditional and nontraditional cardiometabolic parameters in obese adolescent girls" in Journal of Medical Biochemistry, 35, no. 3 (2016):282-292,
https://doi.org/10.1515/jomb-2016-0005 . .