TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Bjelaković, Bojko
AU  - Jovanović, Milovan
AU  - Zvrko, Elvir
AU  - Stanišić, Verica
AU  - Ninić, Ana
AU  - Šćepanović, Anđelka
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3239
AB  - Reynolds Risk Score (RRS) is regarded as a good screening tool for cardiovascular disease (CVD) risk. Since CVD is the leading cause of death in Montenegro, we aimed to assess the risk of CVD as assessed by RRS and to examine its association with cardiometabolic parameters in apparently healthy middle-aged population. In addition, we aimed to test whether obesity had an independent influence on RRS. A total of 132 participants (mean age 56.2 +/- 6.73 years, 69% females) were included. Body mass index (BMI), waist circumference (WC), blood pressure (BP) and biochemical parameters (fasting glucose, insulin, lipid parameters, creatinine and high sensitivity C-reactive protein) were determined. Insulin resistance (HOMA-IR) and glomerular filtration rate (eGFR) were calculated. Compared with females, a significantly higher number of males were in the high RRS subgroup (chi(2) =45.9, p lt 0.001). Furthermore, significantly higher fasting glucose (p=0.030), insulin, HOMA-IR, triglycerides (p lt 0.001 all), anthropometric parameters (e.g., BMI and WC; p=0.004 and p lt 0.001, respectively), and creatinine, but lower eGFR and HDL-c (p lt 0.001 both) were recorded in the high-risk subgroup compared with low and medium risk subgroups. In all participants, in addition to LDL-c, diastolic BP and creatinine, WC was independently positively associated with RRS (beta=0.194, p=0.006; lt b> beta=0186, p=0.001; beta=0167, p=0.001; and beta=0.305, p=0.019, respectively), and 40% of variation in RRS could be explained with this model. In conclusion, middle-aged population with higher WC should be screened for RRS in order to estimate CVD risk.
PB  - Sestre Milosrdnice Univ Hospital, Zagreb
T2  - Acta Clinica Croatica
T1  - Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro
VL  - 57
IS  - 1
SP  - 22
EP  - 30
DO  - 10.20471/acc.2018.57.01.03
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Bjelaković, Bojko and Jovanović, Milovan and Zvrko, Elvir and Stanišić, Verica and Ninić, Ana and Šćepanović, Anđelka",
year = "2018",
abstract = "Reynolds Risk Score (RRS) is regarded as a good screening tool for cardiovascular disease (CVD) risk. Since CVD is the leading cause of death in Montenegro, we aimed to assess the risk of CVD as assessed by RRS and to examine its association with cardiometabolic parameters in apparently healthy middle-aged population. In addition, we aimed to test whether obesity had an independent influence on RRS. A total of 132 participants (mean age 56.2 +/- 6.73 years, 69% females) were included. Body mass index (BMI), waist circumference (WC), blood pressure (BP) and biochemical parameters (fasting glucose, insulin, lipid parameters, creatinine and high sensitivity C-reactive protein) were determined. Insulin resistance (HOMA-IR) and glomerular filtration rate (eGFR) were calculated. Compared with females, a significantly higher number of males were in the high RRS subgroup (chi(2) =45.9, p lt 0.001). Furthermore, significantly higher fasting glucose (p=0.030), insulin, HOMA-IR, triglycerides (p lt 0.001 all), anthropometric parameters (e.g., BMI and WC; p=0.004 and p lt 0.001, respectively), and creatinine, but lower eGFR and HDL-c (p lt 0.001 both) were recorded in the high-risk subgroup compared with low and medium risk subgroups. In all participants, in addition to LDL-c, diastolic BP and creatinine, WC was independently positively associated with RRS (beta=0.194, p=0.006; lt b> beta=0186, p=0.001; beta=0167, p=0.001; and beta=0.305, p=0.019, respectively), and 40% of variation in RRS could be explained with this model. In conclusion, middle-aged population with higher WC should be screened for RRS in order to estimate CVD risk.",
publisher = "Sestre Milosrdnice Univ Hospital, Zagreb",
journal = "Acta Clinica Croatica",
title = "Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro",
volume = "57",
number = "1",
pages = "22-30",
doi = "10.20471/acc.2018.57.01.03"
}

Klisić, A., Kavarić, N., Bjelaković, B., Jovanović, M., Zvrko, E., Stanišić, V., Ninić, A.,& Šćepanović, A.. (2018). Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro. in Acta Clinica Croatica
Sestre Milosrdnice Univ Hospital, Zagreb., 57(1), 22-30.
https://doi.org/10.20471/acc.2018.57.01.03

Klisić A, Kavarić N, Bjelaković B, Jovanović M, Zvrko E, Stanišić V, Ninić A, Šćepanović A. Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro. in Acta Clinica Croatica. 2018;57(1):22-30.
doi:10.20471/acc.2018.57.01.03 .

Klisić, Aleksandra, Kavarić, Nebojša, Bjelaković, Bojko, Jovanović, Milovan, Zvrko, Elvir, Stanišić, Verica, Ninić, Ana, Šćepanović, Anđelka, "Cardiovascular risk assessed by reynolds risk score in relation to waist circumference in apparently healthy middle-aged population in Montenegro" in Acta Clinica Croatica, 57, no. 1 (2018):22-30,
https://doi.org/10.20471/acc.2018.57.01.03 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Isaković, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Zvrko, Elvir
AU  - Skerović, Verica
AU  - Ninić, Ana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3233
AB  - Introduction/Aim Considering the high prevalence of nonalcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate the potential benefit of determining markers of oxidative stress, inflammation and dyslipidemia for prediction of NAFLD, as estimated with fatty liver index (FLI) in individuals with DM2. Methods A total of 139 individuals with DM2 (of them 49.9 % females) were enrolled in cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure were obtained. A FLI was calculated. Results Multivariate logistic regression analysis showed that high density lipoprotein cholesterol (HDL-c) and malondialdehyde (MDA) were independent predictors of higher FLI [Odds ratio (OR) = 0.056, p = 0.029; and OR = 1.105, p = 0.016, respectively]. In Receiver Operating Characteristic curve analysis, the addition of fatty liver risk factors (e.g., age, gender, body height, smoking status, diabetes duration and drugs metabolized in liver) to each analysed biochemical parameter [HDL-c, non-HDL-c, high sensitivity C-reactive protein (hsCRP), MDA and advanced oxidant protein products (AOPP)] in Model 1, increased the ability to discriminate patients with and without fatty liver [Area under the curve (AUC) = 0.832, AUC = 0.808, AUC = 0.798, AUC = 0.824 and AUC = 0.743, respectively]. Model 2 (which included all five examined predictors, e.g., HDL-c, non-HDL-c, hsCRP, MDA, AOPP, and fatty liver risk factors) improved discriminative abilities for fatty liver status (AUC = 0.909). Even more, Model 2 had the highest sensitivity and specificity (89.3 % and 87.5 %, respectively) together than each predictor in Model 1. Conclusion Multimarker approach, including biomarkers of oxidative stress, dyslipidemia and inflammation, could be of benefit in identifying patients with diabetes being at high risk of fatty liver disease.
PB  - Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart
T2  - Experimental and Clinical Endocrinology & Diabetes
T1  - Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus
VL  - 126
IS  - 6
SP  - 371
EP  - 378
DO  - 10.1055/s-0043-118667
ER  - 

@article{
author = "Klisić, Aleksandra and Isaković, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Jovanović, Milovan and Zvrko, Elvir and Skerović, Verica and Ninić, Ana",
year = "2018",
abstract = "Introduction/Aim Considering the high prevalence of nonalcoholic fatty liver disease (NAFLD) in individuals with type 2 diabetes mellitus (DM2), we aimed to investigate the potential benefit of determining markers of oxidative stress, inflammation and dyslipidemia for prediction of NAFLD, as estimated with fatty liver index (FLI) in individuals with DM2. Methods A total of 139 individuals with DM2 (of them 49.9 % females) were enrolled in cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure were obtained. A FLI was calculated. Results Multivariate logistic regression analysis showed that high density lipoprotein cholesterol (HDL-c) and malondialdehyde (MDA) were independent predictors of higher FLI [Odds ratio (OR) = 0.056, p = 0.029; and OR = 1.105, p = 0.016, respectively]. In Receiver Operating Characteristic curve analysis, the addition of fatty liver risk factors (e.g., age, gender, body height, smoking status, diabetes duration and drugs metabolized in liver) to each analysed biochemical parameter [HDL-c, non-HDL-c, high sensitivity C-reactive protein (hsCRP), MDA and advanced oxidant protein products (AOPP)] in Model 1, increased the ability to discriminate patients with and without fatty liver [Area under the curve (AUC) = 0.832, AUC = 0.808, AUC = 0.798, AUC = 0.824 and AUC = 0.743, respectively]. Model 2 (which included all five examined predictors, e.g., HDL-c, non-HDL-c, hsCRP, MDA, AOPP, and fatty liver risk factors) improved discriminative abilities for fatty liver status (AUC = 0.909). Even more, Model 2 had the highest sensitivity and specificity (89.3 % and 87.5 %, respectively) together than each predictor in Model 1. Conclusion Multimarker approach, including biomarkers of oxidative stress, dyslipidemia and inflammation, could be of benefit in identifying patients with diabetes being at high risk of fatty liver disease.",
publisher = "Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart",
journal = "Experimental and Clinical Endocrinology & Diabetes",
title = "Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus",
volume = "126",
number = "6",
pages = "371-378",
doi = "10.1055/s-0043-118667"
}

Klisić, A., Isaković, A., Kocić, G., Kavarić, N., Jovanović, M., Zvrko, E., Skerović, V.,& Ninić, A.. (2018). Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus. in Experimental and Clinical Endocrinology & Diabetes
Johann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh, Stuttgart., 126(6), 371-378.
https://doi.org/10.1055/s-0043-118667

Klisić A, Isaković A, Kocić G, Kavarić N, Jovanović M, Zvrko E, Skerović V, Ninić A. Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus. in Experimental and Clinical Endocrinology & Diabetes. 2018;126(6):371-378.
doi:10.1055/s-0043-118667 .

Klisić, Aleksandra, Isaković, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Jovanović, Milovan, Zvrko, Elvir, Skerović, Verica, Ninić, Ana, "Relationship between Oxidative Stress, Inflammation and Dyslipidemia with Fatty Liver Index in Patients with Type 2 Diabetes Mellitus" in Experimental and Clinical Endocrinology & Diabetes, 126, no. 6 (2018):371-378,
https://doi.org/10.1055/s-0043-118667 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kocić, Gordana
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Stanišić, Verica
AU  - Ninić, Ana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3161
AB  - Xanthine oxidase (XO) is an important enzyme responsible for conversion of purine bases to uric acid and represents the major source of reactive oxygen species (ROS) production in circulation. Since pathophysiological mechanism of the relationship between XO activity and urinary albumin excretion (UAE) rate is not well elucidated, we aimed to investigate this association in patients with diabetes mellitus type 2 (DM2). In addition, we wanted to examine whether uric acid itself plays an independent role in albuminuria onset and progression, or it is only mediated through XO activity. A total of 83 patients with DM2 (of them 56.6% females) were included in this cross-sectional study. Anthropometric, biochemical parameters and blood pressure were obtained. Multivariate logistic regression analysis showed that uric acid and XO were the independent predictors for albuminuria onset in patients with DM2 [odds ratio (OR) 1.015, 95% CI (1.008-1.028), p = 0.026 and OR 1.015, 95% CI (1.006-1.026), p = 0.040, respectively]. Rise in uric acid for 1 mu mol/L enhanced the probability for albuminuria by 1.5%. Also, elevation in XO activity for 1 U/L increased the probability for albuminuria for 1.5%. A total of 66.7% of variation in UAE could be explained with this Model. Both XO and uric acid are independently associated with albuminuria in diabetes. Better understanding of pathophysiological relationship between oxidative stress and albuminuria could lead to discoveries of best pharmacological treatment of XO- and/or uric acid-induced ROS, in order to prevent albuminuria onset and progression.
PB  - Springer-Verlag Italia Srl, Milan
T2  - Clinical and Experimental Medicine
T1  - Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2
VL  - 18
IS  - 2
SP  - 283
EP  - 290
DO  - 10.1007/s10238-017-0483-0
ER  - 

@article{
author = "Klisić, Aleksandra and Kocić, Gordana and Kavarić, Nebojša and Jovanović, Milovan and Stanišić, Verica and Ninić, Ana",
year = "2018",
abstract = "Xanthine oxidase (XO) is an important enzyme responsible for conversion of purine bases to uric acid and represents the major source of reactive oxygen species (ROS) production in circulation. Since pathophysiological mechanism of the relationship between XO activity and urinary albumin excretion (UAE) rate is not well elucidated, we aimed to investigate this association in patients with diabetes mellitus type 2 (DM2). In addition, we wanted to examine whether uric acid itself plays an independent role in albuminuria onset and progression, or it is only mediated through XO activity. A total of 83 patients with DM2 (of them 56.6% females) were included in this cross-sectional study. Anthropometric, biochemical parameters and blood pressure were obtained. Multivariate logistic regression analysis showed that uric acid and XO were the independent predictors for albuminuria onset in patients with DM2 [odds ratio (OR) 1.015, 95% CI (1.008-1.028), p = 0.026 and OR 1.015, 95% CI (1.006-1.026), p = 0.040, respectively]. Rise in uric acid for 1 mu mol/L enhanced the probability for albuminuria by 1.5%. Also, elevation in XO activity for 1 U/L increased the probability for albuminuria for 1.5%. A total of 66.7% of variation in UAE could be explained with this Model. Both XO and uric acid are independently associated with albuminuria in diabetes. Better understanding of pathophysiological relationship between oxidative stress and albuminuria could lead to discoveries of best pharmacological treatment of XO- and/or uric acid-induced ROS, in order to prevent albuminuria onset and progression.",
publisher = "Springer-Verlag Italia Srl, Milan",
journal = "Clinical and Experimental Medicine",
title = "Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2",
volume = "18",
number = "2",
pages = "283-290",
doi = "10.1007/s10238-017-0483-0"
}

Klisić, A., Kocić, G., Kavarić, N., Jovanović, M., Stanišić, V.,& Ninić, A.. (2018). Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2. in Clinical and Experimental Medicine
Springer-Verlag Italia Srl, Milan., 18(2), 283-290.
https://doi.org/10.1007/s10238-017-0483-0

Klisić A, Kocić G, Kavarić N, Jovanović M, Stanišić V, Ninić A. Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2. in Clinical and Experimental Medicine. 2018;18(2):283-290.
doi:10.1007/s10238-017-0483-0 .

Klisić, Aleksandra, Kocić, Gordana, Kavarić, Nebojša, Jovanović, Milovan, Stanišić, Verica, Ninić, Ana, "Xanthine oxidase and uric acid as independent predictors of albuminuria in patients with diabetes mellitus type 2" in Clinical and Experimental Medicine, 18, no. 2 (2018):283-290,
https://doi.org/10.1007/s10238-017-0483-0 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Stanišić, Verica
AU  - Jovanović, Milovan
AU  - Kavarić, Nebojša
AU  - Ninić, Ana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2973
AB  - Aim: Retinol-binding protein 4 (RBP4) is a novel adipokine closely related to insulin resistance. However, data on the influence of menopausal status on serum RBP4 are scarce. Therefore, the aim of the current study was to examine whether RBP4 levels are associated with menopausal status per se, independently of insulin resistance. Methods: A total of 30 premenopausal and 100 postmenopausal women non-treated with medications were included in the cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure (BP) were obtained. The homeostasis model assessment of insulin resistance (HOMA-IR) and estimated glomerular filtration rate (eGFR) were calculated. Results: Postmenopausal women displayed higher RBP4 and an unfavorable cardiometabolic profile, compared to premenopausal ones. Multiple linear regression analysis showed that in addition to high triglycerides level (beta=0.315; p=0.002), decreased eGFR (beta=-0.258; p=0.004) and high systolic BP (beta=0.418; p=0.028), menopause per se is an independent predictor of higher RBP4 levels (beta=0.240; p=0.016), (R2-adjusted=0.310; F=6,522; p lt 0.001). Conclusions: Serum RBP4 levels are dependent of menopausal status, which should be taken into account when examining the role of this adipokine in cardiometabolic diseases' occurrence.
AB  - Cilj: Retinol-vezujući protein 4 (RBP4) je novi adipokin, usko povezan sa insulinskom rezistencijom. Međutim, nema dovoljno podataka u literaturi o uticaju menopauze na vrednosti ovog proteina u serumu. Zato je cilj ove studije bio da se ispita da li je povezanost menopauze i RBP4 nezavisna ili je posredovana insulinskom rezistencijom. Metode: Ukupno 30 žena u premenopauzi i 100 žena u postmenopauzi, koje nisu na terapiji su uključene u studiju preseka. Mereni su antropometrijski i biohemijski parametri, kao i krvni pritisak (KP), HOMA indeksi, procenjena jačina glomerularne filtracije (JGF) i izračunati su. Rezultati: Kod žena u postmenopauzi zabeležene su veće vrednosti RBP4 i nepovoljniji kardiometabolički profil, u poređenju sa ženama u premenopauzi. Višestruka linearnaregresiona analiza je pokazala da su više vrednosti triglicerida (beta=0,315; p=0,002), smanjena JGF (beta=-0,258; p=0,004), više vrednosti sistolnog KP (beta=0,418; p=0,028), i menopauza (beta=0,240; p=0,016), nezavisni prediktori povišenih vrednosti RBP4 u serumu (R2-adjusted=0,310; F=6,522; p lt 0,001). Zaključak: Menopauza utiče na vrednosti RBP4 u serumu, što treba uzeti u obzir prilikom ispitivanja uloge ovog adipokina u pojavi kardiometaboličkih poremećaja.
PB  - Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar
T2  - Timočki medicinski glasnik
T1  - Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels
T1  - Menopauza kao nezavisni prediktor povišenih vrednosti retinolvezujućeg proteina 4 u serumu
VL  - 42
IS  - 4
SP  - 199
EP  - 205
DO  - 10.5937/tmg1704199K
ER  - 

@article{
author = "Klisić, Aleksandra and Stanišić, Verica and Jovanović, Milovan and Kavarić, Nebojša and Ninić, Ana",
year = "2017",
abstract = "Aim: Retinol-binding protein 4 (RBP4) is a novel adipokine closely related to insulin resistance. However, data on the influence of menopausal status on serum RBP4 are scarce. Therefore, the aim of the current study was to examine whether RBP4 levels are associated with menopausal status per se, independently of insulin resistance. Methods: A total of 30 premenopausal and 100 postmenopausal women non-treated with medications were included in the cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure (BP) were obtained. The homeostasis model assessment of insulin resistance (HOMA-IR) and estimated glomerular filtration rate (eGFR) were calculated. Results: Postmenopausal women displayed higher RBP4 and an unfavorable cardiometabolic profile, compared to premenopausal ones. Multiple linear regression analysis showed that in addition to high triglycerides level (beta=0.315; p=0.002), decreased eGFR (beta=-0.258; p=0.004) and high systolic BP (beta=0.418; p=0.028), menopause per se is an independent predictor of higher RBP4 levels (beta=0.240; p=0.016), (R2-adjusted=0.310; F=6,522; p lt 0.001). Conclusions: Serum RBP4 levels are dependent of menopausal status, which should be taken into account when examining the role of this adipokine in cardiometabolic diseases' occurrence., Cilj: Retinol-vezujući protein 4 (RBP4) je novi adipokin, usko povezan sa insulinskom rezistencijom. Međutim, nema dovoljno podataka u literaturi o uticaju menopauze na vrednosti ovog proteina u serumu. Zato je cilj ove studije bio da se ispita da li je povezanost menopauze i RBP4 nezavisna ili je posredovana insulinskom rezistencijom. Metode: Ukupno 30 žena u premenopauzi i 100 žena u postmenopauzi, koje nisu na terapiji su uključene u studiju preseka. Mereni su antropometrijski i biohemijski parametri, kao i krvni pritisak (KP), HOMA indeksi, procenjena jačina glomerularne filtracije (JGF) i izračunati su. Rezultati: Kod žena u postmenopauzi zabeležene su veće vrednosti RBP4 i nepovoljniji kardiometabolički profil, u poređenju sa ženama u premenopauzi. Višestruka linearnaregresiona analiza je pokazala da su više vrednosti triglicerida (beta=0,315; p=0,002), smanjena JGF (beta=-0,258; p=0,004), više vrednosti sistolnog KP (beta=0,418; p=0,028), i menopauza (beta=0,240; p=0,016), nezavisni prediktori povišenih vrednosti RBP4 u serumu (R2-adjusted=0,310; F=6,522; p lt 0,001). Zaključak: Menopauza utiče na vrednosti RBP4 u serumu, što treba uzeti u obzir prilikom ispitivanja uloge ovog adipokina u pojavi kardiometaboličkih poremećaja.",
publisher = "Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar",
journal = "Timočki medicinski glasnik",
title = "Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels, Menopauza kao nezavisni prediktor povišenih vrednosti retinolvezujućeg proteina 4 u serumu",
volume = "42",
number = "4",
pages = "199-205",
doi = "10.5937/tmg1704199K"
}

Klisić, A., Stanišić, V., Jovanović, M., Kavarić, N.,& Ninić, A.. (2017). Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels. in Timočki medicinski glasnik
Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar., 42(4), 199-205.
https://doi.org/10.5937/tmg1704199K

Klisić A, Stanišić V, Jovanović M, Kavarić N, Ninić A. Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels. in Timočki medicinski glasnik. 2017;42(4):199-205.
doi:10.5937/tmg1704199K .

Klisić, Aleksandra, Stanišić, Verica, Jovanović, Milovan, Kavarić, Nebojša, Ninić, Ana, "Menopausal status as an independent predictor of high serum retinol-binding protein 4 levels" in Timočki medicinski glasnik, 42, no. 4 (2017):199-205,
https://doi.org/10.5937/tmg1704199K . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Stanišić, Verica
AU  - Jovanović, Milovan
AU  - Kavarić, Nebojša
AU  - Ninić, Ana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2914
AB  - Aim: Although previous studies confirmed the association between obesity and hypertension, the underlying pathophysiological mechanism is not well elucidated, specially considering the fact that discordant results exist when examining the independent role of obesity and/or insulin resistance on risk for hypertension onset. Therefore, we aimed to examine if obesity [as measured with body mass index (BMI)] is a predictor for hypertension, independently of insulin resistance [as measured with Homeostasis model assessment of insulin resistance (HOMA-IR)] in the cohort of postmenopausal women. Methods: A total of 150 postmenopausal women non-treated with medications(among them 44.7% hypertensive)were included in cross-sectional study. Anthropometric and biochemical parameters, so as blood pressure were obtained. HOMA-IR was calculated. Results: Multivariate logistic regression analysisrevealed that both, BMI and HOMA-IR were the independent predictors of blood pressure in postmenopausal women (OR=1.240, p=0.035 and OR=2.419, p=0.008, respectively). Rise in BMI for 1 kg/m2 enhanced the probability for higher blood pressure by 24%. Also, elevation in HOMA-IR for 1 unit, rose the probability for higher blood pressure almost 2.5 times. Even 47% of variation in blood pressure could be explained with this Model. Also, this Model correctly classified 76% of postmenopausal women having hypertension. Conclusions: Both, obesity and insulin resistance are the independent predictors of blood pressure in postmenopausal women.
AB  - Cilj: Premda su ranije studije potvrdile vezu između gojaznosti i hipertenzije, patofiziološki mehanizam ove povezanosti još uvek nije rasvetljen, naročito što postoje oprečni rezultati kada je u pitanju nezavisna uloga gojaznosti i/ili insulinske rezistencije u nastanku hipertenzije. Stoga je cilj studije bio da se ispita da li je gojaznost [merena indeksom telesne mase (ITM)] prediktor za nastanak hipertenzije, nezavisno od insulinske rezistencije [merene HOMA indeksom (HOMA-IR)] u kohorti žena u postmenopauzi. Metode: Ukupno 150 žena u postmenopauzi koje nisu na terapiji (među njima 44,7% sa hipertenzijom) su uključene u studiju preseka. Antropometrijski i biohemijski parametri, kao i krvni pritisak su mereni. HOMA-IR je računat. Rezultati: Multivarijantna logistička regresiona analiza je pokazala da su i ITM (OR=1,240; p=0,035) i HOMA-IR (OR=2,419; p=0,008)nezavisni prediktori krvnog pritiska kod žena u postmenopauzi. Povećanje ITMza1 kg/m2 povećava verovatnoću za pojavu hipertenzije za 24%. Takođe, porast HOMA-IR za 1 jedinicu povećava verovatnoću za pojavu hipertenzije za skoro 2,5 puta. Čak 47% varijacije u vrednosti krvnog pritiska može biti objašnjeno ovim modelom. Takođe, ovaj model je ispravno klasifikovao 76% žena u postmenopauzi koje imaju hipertenziju. Zaključak: I gojaznost, i insulinska rezistencija su nezavisni prediktori krvnog pritiska kod žena u postmenopauzi.
PB  - Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar
T2  - Timočki medicinski glasnik
T1  - Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women
T1  - Indeks telesne mase i insulinska rezistencija kao nezavisni prediktori hipertenzije kod žena u postmenopauzi
VL  - 42
IS  - 3
SP  - 165
EP  - 172
DO  - 10.5937/tmg1703165K
ER  - 

@article{
author = "Klisić, Aleksandra and Stanišić, Verica and Jovanović, Milovan and Kavarić, Nebojša and Ninić, Ana",
year = "2017",
abstract = "Aim: Although previous studies confirmed the association between obesity and hypertension, the underlying pathophysiological mechanism is not well elucidated, specially considering the fact that discordant results exist when examining the independent role of obesity and/or insulin resistance on risk for hypertension onset. Therefore, we aimed to examine if obesity [as measured with body mass index (BMI)] is a predictor for hypertension, independently of insulin resistance [as measured with Homeostasis model assessment of insulin resistance (HOMA-IR)] in the cohort of postmenopausal women. Methods: A total of 150 postmenopausal women non-treated with medications(among them 44.7% hypertensive)were included in cross-sectional study. Anthropometric and biochemical parameters, so as blood pressure were obtained. HOMA-IR was calculated. Results: Multivariate logistic regression analysisrevealed that both, BMI and HOMA-IR were the independent predictors of blood pressure in postmenopausal women (OR=1.240, p=0.035 and OR=2.419, p=0.008, respectively). Rise in BMI for 1 kg/m2 enhanced the probability for higher blood pressure by 24%. Also, elevation in HOMA-IR for 1 unit, rose the probability for higher blood pressure almost 2.5 times. Even 47% of variation in blood pressure could be explained with this Model. Also, this Model correctly classified 76% of postmenopausal women having hypertension. Conclusions: Both, obesity and insulin resistance are the independent predictors of blood pressure in postmenopausal women., Cilj: Premda su ranije studije potvrdile vezu između gojaznosti i hipertenzije, patofiziološki mehanizam ove povezanosti još uvek nije rasvetljen, naročito što postoje oprečni rezultati kada je u pitanju nezavisna uloga gojaznosti i/ili insulinske rezistencije u nastanku hipertenzije. Stoga je cilj studije bio da se ispita da li je gojaznost [merena indeksom telesne mase (ITM)] prediktor za nastanak hipertenzije, nezavisno od insulinske rezistencije [merene HOMA indeksom (HOMA-IR)] u kohorti žena u postmenopauzi. Metode: Ukupno 150 žena u postmenopauzi koje nisu na terapiji (među njima 44,7% sa hipertenzijom) su uključene u studiju preseka. Antropometrijski i biohemijski parametri, kao i krvni pritisak su mereni. HOMA-IR je računat. Rezultati: Multivarijantna logistička regresiona analiza je pokazala da su i ITM (OR=1,240; p=0,035) i HOMA-IR (OR=2,419; p=0,008)nezavisni prediktori krvnog pritiska kod žena u postmenopauzi. Povećanje ITMza1 kg/m2 povećava verovatnoću za pojavu hipertenzije za 24%. Takođe, porast HOMA-IR za 1 jedinicu povećava verovatnoću za pojavu hipertenzije za skoro 2,5 puta. Čak 47% varijacije u vrednosti krvnog pritiska može biti objašnjeno ovim modelom. Takođe, ovaj model je ispravno klasifikovao 76% žena u postmenopauzi koje imaju hipertenziju. Zaključak: I gojaznost, i insulinska rezistencija su nezavisni prediktori krvnog pritiska kod žena u postmenopauzi.",
publisher = "Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar",
journal = "Timočki medicinski glasnik",
title = "Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women, Indeks telesne mase i insulinska rezistencija kao nezavisni prediktori hipertenzije kod žena u postmenopauzi",
volume = "42",
number = "3",
pages = "165-172",
doi = "10.5937/tmg1703165K"
}

Klisić, A., Stanišić, V., Jovanović, M., Kavarić, N.,& Ninić, A.. (2017). Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women. in Timočki medicinski glasnik
Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar., 42(3), 165-172.
https://doi.org/10.5937/tmg1703165K

Klisić A, Stanišić V, Jovanović M, Kavarić N, Ninić A. Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women. in Timočki medicinski glasnik. 2017;42(3):165-172.
doi:10.5937/tmg1703165K .

Klisić, Aleksandra, Stanišić, Verica, Jovanović, Milovan, Kavarić, Nebojša, Ninić, Ana, "Body mass index and insulin resistance as independent predictors of hypertension in postmenopausal women" in Timočki medicinski glasnik, 42, no. 3 (2017):165-172,
https://doi.org/10.5937/tmg1703165K . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Zvrko, Elvir
AU  - Skerović, Verica
AU  - Šćepanović, Anđelka
AU  - Medin, Darko
AU  - Ninić, Ana
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2835
AB  - Background: Recent studies hypothesize that dyslipidemia can predict glycated hemoglobin (HbA1c) and could be important contributing factor to the pathogenesis of type 2 diabetes mellitus (DM2). Therefore, we aimed to evaluate the influence of lipid parameters on long-term glycemic control in DM2. Materials and Methods: A total of 275 sedentary DM2 (mean [+/- standard deviation] age 60.6 [+/- 10.0] years) who volunteered to participate in this cross-sectional study were enrolled. Anthropometric (body weight, body hight, and waist circumference), biochemical parameters (fasting glucose, HbA1c, lipid parameters, creatinine), as well as blood pressure were obtained. Results: Total cholesterol (odds ratio [OR] = 1.30, 95% confidence interval [CI] [1.02-1.66], P = 0.032), triglycerides (OR = 1.34, 95% CI (1.07-1.67), P = 0.010), and low density lipoprotein cholesterol (OR = 1.42, 95% CI [1.10-1.83], P = 0.006) were the independent predictors of higher HBA1c, and as they increased by 1 mmol/L each, probabilities of higher HBA1c increased by 30%, 34%, and 42%, respectively. Low level of high-density lipoprotein cholesterol (HDL-c) was found to be the independent predictor of higher HBA1c (OR = 0.44, 95% CI [0.20-0.67], P = 0.039), and increase in HDL-c by 1 mmol/L, reduced the probability of higher HBA1c by 56%. Conclusion: Unfavorable lipid profile can predict HbA1c level in DM2 patients. Early diagnosis of dyslipidemia, as well as its monitoring and maintaining good lipids control can be used as a preventive measure for optimal long-term glycemic control.
PB  - Wolters Kluwer Medknow Publications, Mumbai
T2  - Journal of Research in Medical Sciences
T1  - Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus
VL  - 22
DO  - 10.4103/jrms.JRMS_284_17
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Jovanović, Milovan and Zvrko, Elvir and Skerović, Verica and Šćepanović, Anđelka and Medin, Darko and Ninić, Ana",
year = "2017",
abstract = "Background: Recent studies hypothesize that dyslipidemia can predict glycated hemoglobin (HbA1c) and could be important contributing factor to the pathogenesis of type 2 diabetes mellitus (DM2). Therefore, we aimed to evaluate the influence of lipid parameters on long-term glycemic control in DM2. Materials and Methods: A total of 275 sedentary DM2 (mean [+/- standard deviation] age 60.6 [+/- 10.0] years) who volunteered to participate in this cross-sectional study were enrolled. Anthropometric (body weight, body hight, and waist circumference), biochemical parameters (fasting glucose, HbA1c, lipid parameters, creatinine), as well as blood pressure were obtained. Results: Total cholesterol (odds ratio [OR] = 1.30, 95% confidence interval [CI] [1.02-1.66], P = 0.032), triglycerides (OR = 1.34, 95% CI (1.07-1.67), P = 0.010), and low density lipoprotein cholesterol (OR = 1.42, 95% CI [1.10-1.83], P = 0.006) were the independent predictors of higher HBA1c, and as they increased by 1 mmol/L each, probabilities of higher HBA1c increased by 30%, 34%, and 42%, respectively. Low level of high-density lipoprotein cholesterol (HDL-c) was found to be the independent predictor of higher HBA1c (OR = 0.44, 95% CI [0.20-0.67], P = 0.039), and increase in HDL-c by 1 mmol/L, reduced the probability of higher HBA1c by 56%. Conclusion: Unfavorable lipid profile can predict HbA1c level in DM2 patients. Early diagnosis of dyslipidemia, as well as its monitoring and maintaining good lipids control can be used as a preventive measure for optimal long-term glycemic control.",
publisher = "Wolters Kluwer Medknow Publications, Mumbai",
journal = "Journal of Research in Medical Sciences",
title = "Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus",
volume = "22",
doi = "10.4103/jrms.JRMS_284_17"
}

Klisić, A., Kavarić, N., Jovanović, M., Zvrko, E., Skerović, V., Šćepanović, A., Medin, D.,& Ninić, A.. (2017). Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus. in Journal of Research in Medical Sciences
Wolters Kluwer Medknow Publications, Mumbai., 22.
https://doi.org/10.4103/jrms.JRMS_284_17

Klisić A, Kavarić N, Jovanović M, Zvrko E, Skerović V, Šćepanović A, Medin D, Ninić A. Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus. in Journal of Research in Medical Sciences. 2017;22.
doi:10.4103/jrms.JRMS_284_17 .

Klisić, Aleksandra, Kavarić, Nebojša, Jovanović, Milovan, Zvrko, Elvir, Skerović, Verica, Šćepanović, Anđelka, Medin, Darko, Ninić, Ana, "Association between unfavorable lipid profile and glycemic control in patients with type 2 diabetes mellitus" in Journal of Research in Medical Sciences, 22 (2017),
https://doi.org/10.4103/jrms.JRMS_284_17 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Soldatović, Ivan
AU  - Gligorović-Barhanović, Najdana
AU  - Kotur-Stevuljević, Jelena
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2800
AB  - Introduction: Previous studies have examined the correlation between hyperandrogenemia and non-alcoholic fatty liver disease (NAFLD) in women and showed contradictory results. Therefore, we aimed to evaluate the relationship between testosterone level and Fatty Liver Index (FLI), as a surrogate marker for NAFLD, in a cohort of postmenopausal women. Material and methods: A total of 150 postmenopausal women were included in this cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure, were obtained. Non-alcoholic fatty liver disease is assessed by FLI, an algorithm based on body mass index, waist circumference, triglycerides and gamma-glutamyl transferase, as a simple and accurate predictor of hepatic steatosis. Women were divided into three groups (FLI  lt  30, n = 80; 30 = FLI  lt  60, n = 44; FLI = 60, n = 26). Homeostasis model assessment of insulin resistance (HOMA-IR) as a surrogate marker of insulin resistance was calculated. Results: Multiple linear regression analysis revealed that the best model consisted of 4 parameters (e.g., bioavailable testosterone (beta = 0.288, p = 0.001), log HOMA-IR (beta = 0.227, p = 0.005), log high-sensitivity C-reactive protein (beta = 0.322, p  lt  0.001), and retinol-binding protein 4 (beta = 0.226, p  lt  0.001)). Adjusted R-2 for the best model was 0.550, which means that as much as 55.0% of variation in FLI could be explained with this model. Conclusions: Bioavailable testosterone is independently associated with FLI in postmenopausal women.
PB  - Termedia Publishing House Ltd, Poznan
T2  - Archives of Medical Science
T1  - Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women
VL  - 13
IS  - 5
SP  - 1188
EP  - 1196
DO  - 10.5114/aoms.2017.68972
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Jovanović, Milovan and Soldatović, Ivan and Gligorović-Barhanović, Najdana and Kotur-Stevuljević, Jelena",
year = "2017",
abstract = "Introduction: Previous studies have examined the correlation between hyperandrogenemia and non-alcoholic fatty liver disease (NAFLD) in women and showed contradictory results. Therefore, we aimed to evaluate the relationship between testosterone level and Fatty Liver Index (FLI), as a surrogate marker for NAFLD, in a cohort of postmenopausal women. Material and methods: A total of 150 postmenopausal women were included in this cross-sectional study. Anthropometric and biochemical parameters, as well as blood pressure, were obtained. Non-alcoholic fatty liver disease is assessed by FLI, an algorithm based on body mass index, waist circumference, triglycerides and gamma-glutamyl transferase, as a simple and accurate predictor of hepatic steatosis. Women were divided into three groups (FLI  lt  30, n = 80; 30 = FLI  lt  60, n = 44; FLI = 60, n = 26). Homeostasis model assessment of insulin resistance (HOMA-IR) as a surrogate marker of insulin resistance was calculated. Results: Multiple linear regression analysis revealed that the best model consisted of 4 parameters (e.g., bioavailable testosterone (beta = 0.288, p = 0.001), log HOMA-IR (beta = 0.227, p = 0.005), log high-sensitivity C-reactive protein (beta = 0.322, p  lt  0.001), and retinol-binding protein 4 (beta = 0.226, p  lt  0.001)). Adjusted R-2 for the best model was 0.550, which means that as much as 55.0% of variation in FLI could be explained with this model. Conclusions: Bioavailable testosterone is independently associated with FLI in postmenopausal women.",
publisher = "Termedia Publishing House Ltd, Poznan",
journal = "Archives of Medical Science",
title = "Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women",
volume = "13",
number = "5",
pages = "1188-1196",
doi = "10.5114/aoms.2017.68972"
}

Klisić, A., Kavarić, N., Jovanović, M., Soldatović, I., Gligorović-Barhanović, N.,& Kotur-Stevuljević, J.. (2017). Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women. in Archives of Medical Science
Termedia Publishing House Ltd, Poznan., 13(5), 1188-1196.
https://doi.org/10.5114/aoms.2017.68972

Klisić A, Kavarić N, Jovanović M, Soldatović I, Gligorović-Barhanović N, Kotur-Stevuljević J. Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women. in Archives of Medical Science. 2017;13(5):1188-1196.
doi:10.5114/aoms.2017.68972 .

Klisić, Aleksandra, Kavarić, Nebojša, Jovanović, Milovan, Soldatović, Ivan, Gligorović-Barhanović, Najdana, Kotur-Stevuljević, Jelena, "Bioavailable testosterone is independently associated with Fatty Liver Index in postmenopausal women" in Archives of Medical Science, 13, no. 5 (2017):1188-1196,
https://doi.org/10.5114/aoms.2017.68972 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2766
AB  - Introduction: At physiological concentrations uric acid (UA) is a powerful antioxidant. However, at higher concentrations UA acts as an oxidant leading to cell damage and consequent risk for many diseases. The underlying mechanism of the relationship between higher UA level and obesityrelated diseases is not well elucidated. Therefore, the aim of the study was to determine the influence of obesity on serum UA level in postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Anthropometric parameters: height, weight and waist circumference (WC) were measured, and body mass index was calculated in all participants. Biochemical parameters: uric acid, fasting glycemia, insulin resistance ((HOMA-IR) was calculated), lipid profile, cystatin C, retinol-binding protein 4 (RBP4), high sensitivity C-reactive protein were determined. Results: After dividing patients according to tertile values of UA concentration, significant increase in anthropometric measurements, HOMA-IR, cystatin C, RBP4, and blood pressure were found in the highest UA tertile. In multiple linear regression analysis, WC (Beta=0.414, p lt 0.001), and cystatin C (Beta=0.300, p lt 0.001), (R2=0.467; p lt 0.001) were the best predictors of higher UA level. Conclusion: Abdominal obesity is the imoprtant determinant of higher UA level in postmenopausal women. A better understanding of underlying mechanisms of hyperuricaemia and adipose tissue disfunction in obesity, such as dysregulation of adipokines and chronic inflammation, together with discovering new target therapy may be of paramount importantance for treating obestity complications.
AB  - Cilj: U fiziološkim koncentracijama mokraćna kiselina (MK) je moćan neenzimski antioksidans. Ipak, u povišenoj koncentraciji, MK ispoljava oksidativno dejstvo, dovodeći do oštećenja ćelije sa posledičnim rizikom za nastanak brojnih oboljenja. Mehanizam putem kojeg povećana koncentracija MK dovodi do oboljenja uzrokovanih gojaznošću nije u potpunosti razjašnjen. Zato je cilj naše studije da se ispita uticaj gojaznosti na serumski nivo MK kod žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama su izvršena antropometrijska merenja, koja su obuhvatila merenje telesne visine, telesne mase i obima struka. Indeks telesne mase je izračunat. Određivani su sledeći biohemijski parametri: MK, glikemija, (insulinska rezistencija [HOMA-IR]), lipidni status, cistatin C, retinol - vezujući protein (RBP4) i visokosenzitivni C-reaktivni protein. Rezultati: Podelom MK na tercilne vrednosti, uočene su najveće vrednosti antropometrijskih parametara, HOMA-IR, RBP4, cistatina C i krvnog pritiska u grupi sa najvišim vrednostima MK. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet MK pokazao je obim struka (Beta=0,414; p lt 0,001), zatim cistatin C (Beta=0,300; p lt 0,001), (R2=0,467; p lt 0,001). Zaključak: Abdominalna gojaznost je važna determinanta povišenih vrednosti MK kod žena u postmenopauzi. Bolje razumevanje mehanizama koji dovode do hiperurikemije i disfunkcije masnog tkiva u gojaznosti, kao što su poremećena regulacija adipocitokina i hronična inflamacija, te otkrivanje dodatnih terapijskih ciljeva, može biti od velikog značaja u lečenju komplikacija gojaznosti.
PB  - Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar
T2  - Timočki medicinski glasnik
T1  - Influence of obesity on serum uric acid level in postmenopausal women
T1  - Uticaj gojaznosti na serumski nivo mokraćne kiseline kod žena u postmenopauzi
VL  - 41
IS  - 1
SP  - 20
EP  - 26
DO  - 10.5937/tmg1601020K
ER  - 

@article{
author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Kavarić, Nebojša and Jovanović, Milovan",
year = "2016",
abstract = "Introduction: At physiological concentrations uric acid (UA) is a powerful antioxidant. However, at higher concentrations UA acts as an oxidant leading to cell damage and consequent risk for many diseases. The underlying mechanism of the relationship between higher UA level and obesityrelated diseases is not well elucidated. Therefore, the aim of the study was to determine the influence of obesity on serum UA level in postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Anthropometric parameters: height, weight and waist circumference (WC) were measured, and body mass index was calculated in all participants. Biochemical parameters: uric acid, fasting glycemia, insulin resistance ((HOMA-IR) was calculated), lipid profile, cystatin C, retinol-binding protein 4 (RBP4), high sensitivity C-reactive protein were determined. Results: After dividing patients according to tertile values of UA concentration, significant increase in anthropometric measurements, HOMA-IR, cystatin C, RBP4, and blood pressure were found in the highest UA tertile. In multiple linear regression analysis, WC (Beta=0.414, p lt 0.001), and cystatin C (Beta=0.300, p lt 0.001), (R2=0.467; p lt 0.001) were the best predictors of higher UA level. Conclusion: Abdominal obesity is the imoprtant determinant of higher UA level in postmenopausal women. A better understanding of underlying mechanisms of hyperuricaemia and adipose tissue disfunction in obesity, such as dysregulation of adipokines and chronic inflammation, together with discovering new target therapy may be of paramount importantance for treating obestity complications., Cilj: U fiziološkim koncentracijama mokraćna kiselina (MK) je moćan neenzimski antioksidans. Ipak, u povišenoj koncentraciji, MK ispoljava oksidativno dejstvo, dovodeći do oštećenja ćelije sa posledičnim rizikom za nastanak brojnih oboljenja. Mehanizam putem kojeg povećana koncentracija MK dovodi do oboljenja uzrokovanih gojaznošću nije u potpunosti razjašnjen. Zato je cilj naše studije da se ispita uticaj gojaznosti na serumski nivo MK kod žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama su izvršena antropometrijska merenja, koja su obuhvatila merenje telesne visine, telesne mase i obima struka. Indeks telesne mase je izračunat. Određivani su sledeći biohemijski parametri: MK, glikemija, (insulinska rezistencija [HOMA-IR]), lipidni status, cistatin C, retinol - vezujući protein (RBP4) i visokosenzitivni C-reaktivni protein. Rezultati: Podelom MK na tercilne vrednosti, uočene su najveće vrednosti antropometrijskih parametara, HOMA-IR, RBP4, cistatina C i krvnog pritiska u grupi sa najvišim vrednostima MK. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet MK pokazao je obim struka (Beta=0,414; p lt 0,001), zatim cistatin C (Beta=0,300; p lt 0,001), (R2=0,467; p lt 0,001). Zaključak: Abdominalna gojaznost je važna determinanta povišenih vrednosti MK kod žena u postmenopauzi. Bolje razumevanje mehanizama koji dovode do hiperurikemije i disfunkcije masnog tkiva u gojaznosti, kao što su poremećena regulacija adipocitokina i hronična inflamacija, te otkrivanje dodatnih terapijskih ciljeva, može biti od velikog značaja u lečenju komplikacija gojaznosti.",
publisher = "Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar",
journal = "Timočki medicinski glasnik",
title = "Influence of obesity on serum uric acid level in postmenopausal women, Uticaj gojaznosti na serumski nivo mokraćne kiseline kod žena u postmenopauzi",
volume = "41",
number = "1",
pages = "20-26",
doi = "10.5937/tmg1601020K"
}

Klisić, A., Kotur-Stevuljević, J., Kavarić, N.,& Jovanović, M.. (2016). Influence of obesity on serum uric acid level in postmenopausal women. in Timočki medicinski glasnik
Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar., 41(1), 20-26.
https://doi.org/10.5937/tmg1601020K

Klisić A, Kotur-Stevuljević J, Kavarić N, Jovanović M. Influence of obesity on serum uric acid level in postmenopausal women. in Timočki medicinski glasnik. 2016;41(1):20-26.
doi:10.5937/tmg1601020K .

Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Kavarić, Nebojša, Jovanović, Milovan, "Influence of obesity on serum uric acid level in postmenopausal women" in Timočki medicinski glasnik, 41, no. 1 (2016):20-26,
https://doi.org/10.5937/tmg1601020K . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Kavarić, Nebojša
AU  - Jovanović, Milovan
AU  - Škerović, Verica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2709
AB  - Higher fibrinogen levels may play an important role in cardiovascular diseases in postmenopausal women. Previous studies have reported its higher levels in obese individuals, as compared with normal weight counterparts. However, the mechanism of the relationship between fibrinogen and cardiometabolic risk factors is not well elucidated. Therefore, we aimed to examine this relationship in overweight/obese postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Blood pressure and anthropometric parameters: height, weight and waist circumference were measured, and body mass index (BMI) was calculated in all participants. Biochemical parameters: fibrinogen, glycemia, (insulin resistance (HOMA-IR) was calculated) and lipid profile (total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, triglycerides/HDLcholesterol ratio, non-HDL-cholesterol) were determined. Results: After dividing patients according to tertile values of fibrinogen concentration, significant increase in BMI (P=0.039), waist circumference (P=0.002), insulin (P=0.005), HOMA-IR (P=0.006), triglycerides (P=0.001), triglycerides/HDL-c ratio (P=0.002) and non-HDL-c (P=0.014) were found in the second and the third fibrinogen tertile, as compared with the first, the lowest level fibrinogen tertile. In multiple linear regression analysis, HOMAIR (Beta=0.225; p=0.007) and triglycerides (Beta=0.188; p=0.023), (R2=0.213; p lt 0.001) were the best predictors of higher fibrinogen level. Conclusion: Fibrinogen may be a useful marker in determining cardiovascular risk in obese postmenopausal women.
AB  - Visoke vrednosti fibrinogena mogu imati važnu ulogu u nastanku kardiovaskularnih bolesti, koje su vodeći uzrok smrtnosti kod žena u postmenopauzi. Ranije studije su pokazale više vrednosti fibrinogena kod gojaznih, u poređenju sa normalno uhranjenim osobama. Ipak, nedovoljno je rasvetljen mehanizam povezanosti fibrinogena sa kardiometaboličkim faktorima rizika koji prate gojaznost. Zato je cilj ove studije bio da se ispita ova povezanost u populaciji predgojaznih/gojaznih žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama meren je krvni pritisak i izvršena su antropometrijska merenja koja su obuhvatila merenje telesne visine, telesne mase i obima struka; izračunat je i indeks telesne mase (ITM). Određivani su sledeći biohemijski parametri: fibrinogen, glikemija, (insulinska rezistencija (HOMA-IR) je izračunata), lipidni status (ukupni holesterol, trigliceridi, LDL-holesterol, HDL-holesterol, odnos trigliceridi/HDL-holesterol, non-HDL-holesterol). Rezultati: Podelom fibrinogena na tercilne vrednosti, u drugoj i trećoj tercilnoj grupi uočene su više vrednosti ITM (P=0,039), obima struka (P=0,002), insulina (P=0,005), HOMA-IR (P=0,006), trigliceridi (P=0,001), odnos trigliceridi/HDL-holesterol (P=0,002) i non- HDL-holesterol (P=0,014) u poređenju sa prvom tercilnom grupom, tj. grupom sa najnižim vrednostima fibrinogena. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet fibrinogena pokazali su HOMA-IR (beta=0,225; p=0,007) i nivo triglicerida (beta=0,188; p=0,023), (R2=0,213; p lt 0,001). Zaključak: Fibrinogen može biti koristan marker za procenu kardiometaboličkog rizika kod gojaznih žena u postmenopauzi.
PB  - Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar
T2  - Timočki medicinski glasnik
T1  - Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women
T1  - Korelacija fibrinogena sa kardiometaboličkim faktorima rizika kod predgojaznih/gojaznih žena u postmenopauzi
VL  - 41
IS  - 2
SP  - 83
EP  - 90
DO  - 10.5937/tmg1602083K
ER  - 

@article{
author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Kavarić, Nebojša and Jovanović, Milovan and Škerović, Verica",
year = "2016",
abstract = "Higher fibrinogen levels may play an important role in cardiovascular diseases in postmenopausal women. Previous studies have reported its higher levels in obese individuals, as compared with normal weight counterparts. However, the mechanism of the relationship between fibrinogen and cardiometabolic risk factors is not well elucidated. Therefore, we aimed to examine this relationship in overweight/obese postmenopausal women. Methods: A total of 100 overweight/obese postmenopausal women were included in this study. Blood pressure and anthropometric parameters: height, weight and waist circumference were measured, and body mass index (BMI) was calculated in all participants. Biochemical parameters: fibrinogen, glycemia, (insulin resistance (HOMA-IR) was calculated) and lipid profile (total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, triglycerides/HDLcholesterol ratio, non-HDL-cholesterol) were determined. Results: After dividing patients according to tertile values of fibrinogen concentration, significant increase in BMI (P=0.039), waist circumference (P=0.002), insulin (P=0.005), HOMA-IR (P=0.006), triglycerides (P=0.001), triglycerides/HDL-c ratio (P=0.002) and non-HDL-c (P=0.014) were found in the second and the third fibrinogen tertile, as compared with the first, the lowest level fibrinogen tertile. In multiple linear regression analysis, HOMAIR (Beta=0.225; p=0.007) and triglycerides (Beta=0.188; p=0.023), (R2=0.213; p lt 0.001) were the best predictors of higher fibrinogen level. Conclusion: Fibrinogen may be a useful marker in determining cardiovascular risk in obese postmenopausal women., Visoke vrednosti fibrinogena mogu imati važnu ulogu u nastanku kardiovaskularnih bolesti, koje su vodeći uzrok smrtnosti kod žena u postmenopauzi. Ranije studije su pokazale više vrednosti fibrinogena kod gojaznih, u poređenju sa normalno uhranjenim osobama. Ipak, nedovoljno je rasvetljen mehanizam povezanosti fibrinogena sa kardiometaboličkim faktorima rizika koji prate gojaznost. Zato je cilj ove studije bio da se ispita ova povezanost u populaciji predgojaznih/gojaznih žena u postmenopauzi. Metode: U ovom istraživanju je bilo uključeno 100 predgojaznih/gojaznih žena u postmenopauzi. Svim ispitanicama meren je krvni pritisak i izvršena su antropometrijska merenja koja su obuhvatila merenje telesne visine, telesne mase i obima struka; izračunat je i indeks telesne mase (ITM). Određivani su sledeći biohemijski parametri: fibrinogen, glikemija, (insulinska rezistencija (HOMA-IR) je izračunata), lipidni status (ukupni holesterol, trigliceridi, LDL-holesterol, HDL-holesterol, odnos trigliceridi/HDL-holesterol, non-HDL-holesterol). Rezultati: Podelom fibrinogena na tercilne vrednosti, u drugoj i trećoj tercilnoj grupi uočene su više vrednosti ITM (P=0,039), obima struka (P=0,002), insulina (P=0,005), HOMA-IR (P=0,006), trigliceridi (P=0,001), odnos trigliceridi/HDL-holesterol (P=0,002) i non- HDL-holesterol (P=0,014) u poređenju sa prvom tercilnom grupom, tj. grupom sa najnižim vrednostima fibrinogena. Primenom višestruke linearne regresije, najveći uticaj na varijabilitet fibrinogena pokazali su HOMA-IR (beta=0,225; p=0,007) i nivo triglicerida (beta=0,188; p=0,023), (R2=0,213; p lt 0,001). Zaključak: Fibrinogen može biti koristan marker za procenu kardiometaboličkog rizika kod gojaznih žena u postmenopauzi.",
publisher = "Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar",
journal = "Timočki medicinski glasnik",
title = "Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women, Korelacija fibrinogena sa kardiometaboličkim faktorima rizika kod predgojaznih/gojaznih žena u postmenopauzi",
volume = "41",
number = "2",
pages = "83-90",
doi = "10.5937/tmg1602083K"
}

Klisić, A., Kotur-Stevuljević, J., Kavarić, N., Jovanović, M.,& Škerović, V.. (2016). Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women. in Timočki medicinski glasnik
Srpsko lekarsko društvo - Podružnica Zaječar, Zaječar., 41(2), 83-90.
https://doi.org/10.5937/tmg1602083K

Klisić A, Kotur-Stevuljević J, Kavarić N, Jovanović M, Škerović V. Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women. in Timočki medicinski glasnik. 2016;41(2):83-90.
doi:10.5937/tmg1602083K .

Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Kavarić, Nebojša, Jovanović, Milovan, Škerović, Verica, "Correlation between fibrinogen level and cardiometabolic risk factors in overweight/obese postmenopausal women" in Timočki medicinski glasnik, 41, no. 2 (2016):83-90,
https://doi.org/10.5937/tmg1602083K . .