TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kotur-Stevuljević, Jelena
AU  - Kavarić, Nebojša
AU  - Martinović, Milica
AU  - Matić, Marija
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3039
AB  - Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P  lt  0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.
PB  - Springer, New York
T2  - Eating and Weight Disorders
T1  - The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women
VL  - 23
IS  - 1
SP  - 133
EP  - 141
DO  - 10.1007/s40519-016-0325-1
ER  - 

@article{
author = "Klisić, Aleksandra and Kotur-Stevuljević, Jelena and Kavarić, Nebojša and Martinović, Milica and Matić, Marija",
year = "2018",
abstract = "Purpose Menopause is frequently associated with an increase in visceral fat, thus modifying redox status by promoting oxidative damage and decreasing antioxidant defense systems. It is known that at higher concentrations estradiol has some antioxidant properties, while its decline in postmenopause is associated with pro-oxidant effects. However, the role of follicle stimulating hormone (FSH) in antioxidant defense in postmenopausal women is still not well elucidated. Therefore, we aimed to evaluate the potential complex association between visceral obesity, FSH and enzymatic antioxidant defense as measured by glutathione peroxidase (GPx) in postmenopausal women. Methods A total of 150 postmenopausal women (mean age 56.6 +/- 4.8 years), among them 50 normal weight and 100 overweight/obese, were included. GPx activity, FSH, luteinizing hormone, estradiol, total testosterone, cardiometabolic and anthropometric parameters, were determined. Results With increasing tertiles of serum FSH levels, significant increase in GPx activity (P = 0.005) was found. Also, the highest number of overweight/obese subjects were in the group with the lowest FSH values (chi(2) = 14.9, P  lt  0.001). After multiple linear regression analysis, the relationship between GPx and FSH disappeared, whereas only higher waist circumference (beta = -0.218, P = 0.045) predicted lower FSH level (adjusted R-2 = 0.227). Conclusion Higher GPx activity is associated with higher FSH level, but abdominal obesity may be the underlying determinant of this relationship.",
publisher = "Springer, New York",
journal = "Eating and Weight Disorders",
title = "The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women",
volume = "23",
number = "1",
pages = "133-141",
doi = "10.1007/s40519-016-0325-1"
}

Klisić, A., Kotur-Stevuljević, J., Kavarić, N., Martinović, M.,& Matić, M.. (2018). The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. in Eating and Weight Disorders
Springer, New York., 23(1), 133-141.
https://doi.org/10.1007/s40519-016-0325-1

Klisić A, Kotur-Stevuljević J, Kavarić N, Martinović M, Matić M. The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women. in Eating and Weight Disorders. 2018;23(1):133-141.
doi:10.1007/s40519-016-0325-1 .

Klisić, Aleksandra, Kotur-Stevuljević, Jelena, Kavarić, Nebojša, Martinović, Milica, Matić, Marija, "The association between follicle stimulating hormone and glutathione peroxidase activity is dependent on abdominal obesity in postmenopausal women" in Eating and Weight Disorders, 23, no. 1 (2018):133-141,
https://doi.org/10.1007/s40519-016-0325-1 . .

TY  - JOUR
AU  - Klisić, Aleksandra
AU  - Kavarić, Nebojša
AU  - Bjelaković, Bojko
AU  - Soldatović, Ivan
AU  - Martinović, Milica
AU  - Kotur-Stevuljević, Jelena
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3017
AB  - Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge, there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Therefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6 +/- 1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e.g., sex, high-density lipoprotein cholesterol (HDL-c), non-HDL-c, smoking, blood pressure and fasting glycemia). According to the risk status, we divided adolescent girls into low, medium and high risk groups (-2  lt = CVRS  lt = 1, 2  lt = CVRS 54 and CVRS >= 5, respectively). We found significantly higher RBP4 in the high risk group as compared with low risk group (p lt 0.001). However, multiple linear regression analysis showed waist circumference (beta=0.257, p=0.031) to be the only independent predictor of higher cardiovascular risk (adjusted R'=0.342, p lt 0.001). In conclusion, RBP4 may be associated with higher cardiovascular risk in overweight/obese adolescent girls, but this association is mediated by abdominal obesity.
PB  - Sestre Milosrdnice Univ Hospital, Zagreb
T2  - Acta Clinica Croatica
T1  - The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls
VL  - 56
IS  - 1
SP  - 92
EP  - 98
DO  - 10.20471/acc.2017.56.01.14
ER  - 

@article{
author = "Klisić, Aleksandra and Kavarić, Nebojša and Bjelaković, Bojko and Soldatović, Ivan and Martinović, Milica and Kotur-Stevuljević, Jelena",
year = "2017",
abstract = "Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge, there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Therefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6 +/- 1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e.g., sex, high-density lipoprotein cholesterol (HDL-c), non-HDL-c, smoking, blood pressure and fasting glycemia). According to the risk status, we divided adolescent girls into low, medium and high risk groups (-2  lt = CVRS  lt = 1, 2  lt = CVRS 54 and CVRS >= 5, respectively). We found significantly higher RBP4 in the high risk group as compared with low risk group (p lt 0.001). However, multiple linear regression analysis showed waist circumference (beta=0.257, p=0.031) to be the only independent predictor of higher cardiovascular risk (adjusted R'=0.342, p lt 0.001). In conclusion, RBP4 may be associated with higher cardiovascular risk in overweight/obese adolescent girls, but this association is mediated by abdominal obesity.",
publisher = "Sestre Milosrdnice Univ Hospital, Zagreb",
journal = "Acta Clinica Croatica",
title = "The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls",
volume = "56",
number = "1",
pages = "92-98",
doi = "10.20471/acc.2017.56.01.14"
}

Klisić, A., Kavarić, N., Bjelaković, B., Soldatović, I., Martinović, M.,& Kotur-Stevuljević, J.. (2017). The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls. in Acta Clinica Croatica
Sestre Milosrdnice Univ Hospital, Zagreb., 56(1), 92-98.
https://doi.org/10.20471/acc.2017.56.01.14

Klisić A, Kavarić N, Bjelaković B, Soldatović I, Martinović M, Kotur-Stevuljević J. The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls. in Acta Clinica Croatica. 2017;56(1):92-98.
doi:10.20471/acc.2017.56.01.14 .

Klisić, Aleksandra, Kavarić, Nebojša, Bjelaković, Bojko, Soldatović, Ivan, Martinović, Milica, Kotur-Stevuljević, Jelena, "The association between retinol-binding protein 4 and cardiovascular risk score is mediated by waist circumference in overweight/obese adolescent girls" in Acta Clinica Croatica, 56, no. 1 (2017):92-98,
https://doi.org/10.20471/acc.2017.56.01.14 . .