TY  - JOUR
AU  - Tešić, Milorad
AU  - Travica, Lazar
AU  - Giga, Vojislav
AU  - Jovanović, Ivana
AU  - Trifunović-Zamaklar, Danijela
AU  - Popović, Dejana
AU  - Mladenović, Đorđe
AU  - Radomirović, Marija
AU  - Vratonjić, Jelena
AU  - Bošković, Nikola
AU  - Dedić, Srđan
AU  - Nedeljković Arsenović, Olga
AU  - Aleksandrić, Srđan
AU  - Juričić, Stefan
AU  - Beleslin, Branko
AU  - Đorđević Dikić, Ana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5203
AB  - Background and Objectives: Mitral valve pathology and mitral regurgitation (MR) are very common in patients with hypertrophic cardiomyopathy (HCM), and the evaluation of mitral valve anatomy and degree of MR is important in patients with HCM. The aim of our study was to examine the potential influence of moderate or moderately severe MR on the prognosis, clinical presentation, and structural characteristics of HCM patients. Materials and Methods: A prospective study examined 176 patients diagnosed with primary asymmetric HCM. According to the severity of the MR, the patients were divided into two groups: Group 1 (n = 116) with no/trace or mild MR and Group 2 (n = 60) with moderate or moderately severe MR. All patients had clinical and echocardiographic examinations, as well as a 24 h Holter ECG. Results: Group 2 had significantly more often the presence of the obstructive type of HCM (p < 0.001), syncope (p = 0.030), NYHA II class (p < 0.001), and atrial fibrillation (p = 0.023). Also, Group 2 had an enlarged left atrial dimension (p < 0.001), left atrial volume index (p < 0.001), and indirectly measured systolic pressure in the right ventricle (p < 0.001). Patients with a higher grade of MR had a significantly higher E/e' (p < 0.001) and, as a result, higher values of Nt pro BNP values (p < 0.001) compared to Group 1. Kaplan-Meier analysis demonstrated that the event-free survival rate during a median follow-up of 88 (IQR 40-112) months was significantly higher in Group 1 compared to Group 2 (84% vs. 45% at 8 years; log-rank 20.4, p < 0.001). After adjustment for relevant confounders, the presence of moderate or moderately severe MR remained as an independent predictor of adverse outcomes (HR 2.788; 95% CI 1.221-6.364, p = 0.015). Conclusions: The presence of moderate or moderately severe MR was associated with unfavorable long-term outcomes in HCM patients.
PB  - MDPI
T2  - Medicina (Kaunas, Lithuania)
T1  - Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy
VL  - 59
IS  - 10
DO  - 10.3390/medicina59101798
ER  - 

@article{
author = "Tešić, Milorad and Travica, Lazar and Giga, Vojislav and Jovanović, Ivana and Trifunović-Zamaklar, Danijela and Popović, Dejana and Mladenović, Đorđe and Radomirović, Marija and Vratonjić, Jelena and Bošković, Nikola and Dedić, Srđan and Nedeljković Arsenović, Olga and Aleksandrić, Srđan and Juričić, Stefan and Beleslin, Branko and Đorđević Dikić, Ana",
year = "2023",
abstract = "Background and Objectives: Mitral valve pathology and mitral regurgitation (MR) are very common in patients with hypertrophic cardiomyopathy (HCM), and the evaluation of mitral valve anatomy and degree of MR is important in patients with HCM. The aim of our study was to examine the potential influence of moderate or moderately severe MR on the prognosis, clinical presentation, and structural characteristics of HCM patients. Materials and Methods: A prospective study examined 176 patients diagnosed with primary asymmetric HCM. According to the severity of the MR, the patients were divided into two groups: Group 1 (n = 116) with no/trace or mild MR and Group 2 (n = 60) with moderate or moderately severe MR. All patients had clinical and echocardiographic examinations, as well as a 24 h Holter ECG. Results: Group 2 had significantly more often the presence of the obstructive type of HCM (p < 0.001), syncope (p = 0.030), NYHA II class (p < 0.001), and atrial fibrillation (p = 0.023). Also, Group 2 had an enlarged left atrial dimension (p < 0.001), left atrial volume index (p < 0.001), and indirectly measured systolic pressure in the right ventricle (p < 0.001). Patients with a higher grade of MR had a significantly higher E/e' (p < 0.001) and, as a result, higher values of Nt pro BNP values (p < 0.001) compared to Group 1. Kaplan-Meier analysis demonstrated that the event-free survival rate during a median follow-up of 88 (IQR 40-112) months was significantly higher in Group 1 compared to Group 2 (84% vs. 45% at 8 years; log-rank 20.4, p < 0.001). After adjustment for relevant confounders, the presence of moderate or moderately severe MR remained as an independent predictor of adverse outcomes (HR 2.788; 95% CI 1.221-6.364, p = 0.015). Conclusions: The presence of moderate or moderately severe MR was associated with unfavorable long-term outcomes in HCM patients.",
publisher = "MDPI",
journal = "Medicina (Kaunas, Lithuania)",
title = "Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy",
volume = "59",
number = "10",
doi = "10.3390/medicina59101798"
}

Tešić, M., Travica, L., Giga, V., Jovanović, I., Trifunović-Zamaklar, D., Popović, D., Mladenović, Đ., Radomirović, M., Vratonjić, J., Bošković, N., Dedić, S., Nedeljković Arsenović, O., Aleksandrić, S., Juričić, S., Beleslin, B.,& Đorđević Dikić, A.. (2023). Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy. in Medicina (Kaunas, Lithuania)
MDPI., 59(10).
https://doi.org/10.3390/medicina59101798

Tešić M, Travica L, Giga V, Jovanović I, Trifunović-Zamaklar D, Popović D, Mladenović Đ, Radomirović M, Vratonjić J, Bošković N, Dedić S, Nedeljković Arsenović O, Aleksandrić S, Juričić S, Beleslin B, Đorđević Dikić A. Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy. in Medicina (Kaunas, Lithuania). 2023;59(10).
doi:10.3390/medicina59101798 .

Tešić, Milorad, Travica, Lazar, Giga, Vojislav, Jovanović, Ivana, Trifunović-Zamaklar, Danijela, Popović, Dejana, Mladenović, Đorđe, Radomirović, Marija, Vratonjić, Jelena, Bošković, Nikola, Dedić, Srđan, Nedeljković Arsenović, Olga, Aleksandrić, Srđan, Juričić, Stefan, Beleslin, Branko, Đorđević Dikić, Ana, "Prognostic Value of Mitral Regurgitation in Patients with Primary Hypertrophic Cardiomyopathy" in Medicina (Kaunas, Lithuania), 59, no. 10 (2023),
https://doi.org/10.3390/medicina59101798 . .

TY  - JOUR
AU  - Vidojević, Dejana
AU  - Seman, Stefan
AU  - Lasica, Ratko
AU  - Tešić, Milorad
AU  - Sarić-Matutinović, Marija
AU  - Jovičić, Snežana
AU  - Ignjatović, Svetlana
AU  - Arena, Ross
AU  - Damjanović, Svetozar
AU  - Popović, Dejana
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3779
AB  - Purpose: Alpha-melanocyte-stimulating hormone (alpha-MSH) has proven cardiovascular effects and plays a significant role as an endogenous countermeasure to ischemia-reperfusion injury. The aim of the current study was to examine the response of alpha-MSH during exercise in patients diagnosed with coronary artery disease (CAD) and evaluate its value in the assessment of severity and prognosis. Methods: Forty subjects with documented CAD (i.e., lesions on coronary angiography ≥ 50%) were included. Cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits, 2–4 days apart, during 2 months of coronary angiography; subsequently, the subjects were followed up for 32 ± 10 months. At rest, at peak CPET, and after 3 min of recovery, plasma levels of alpha-MSH were measured by enzyme-linked immunosorbent assay technique. Results: Mean ejection fraction was 56.7 ± 9.6%. Alpha-MSH similarly increased from rest to peak CPET on both modalities. There were no significant differences in alpha-MSH values during testing in patients with 1,2- and 3-vesel CAD, nor in patients with a SYNTAX score </≥ 23 (p > 0.05). Among CPET and hormonal parameters, ∆alpha-MSH recovery/peak during RE CPET was the best predictor of cardiac event occurrence (chi-square 6.67, HR = 0.51, CI = 0.25–1.02, p = 0.010). Conclusion: ∆alpha-MSH recovery/peak during RE CPET has predictive value for CAD prognosis, demonstrating involvement of alpha-MSH in CAD and a link between stress hormones and cardiac events.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - Hormones
T1  - Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease
VL  - 20
SP  - 381
EP  - 387
DO  - 10.1007/s42000-020-00270-2
ER  - 

@article{
author = "Vidojević, Dejana and Seman, Stefan and Lasica, Ratko and Tešić, Milorad and Sarić-Matutinović, Marija and Jovičić, Snežana and Ignjatović, Svetlana and Arena, Ross and Damjanović, Svetozar and Popović, Dejana",
year = "2021",
abstract = "Purpose: Alpha-melanocyte-stimulating hormone (alpha-MSH) has proven cardiovascular effects and plays a significant role as an endogenous countermeasure to ischemia-reperfusion injury. The aim of the current study was to examine the response of alpha-MSH during exercise in patients diagnosed with coronary artery disease (CAD) and evaluate its value in the assessment of severity and prognosis. Methods: Forty subjects with documented CAD (i.e., lesions on coronary angiography ≥ 50%) were included. Cardiopulmonary exercise testing (CPET) on a treadmill (TM) and recumbent ergometer (RE) were performed on two visits, 2–4 days apart, during 2 months of coronary angiography; subsequently, the subjects were followed up for 32 ± 10 months. At rest, at peak CPET, and after 3 min of recovery, plasma levels of alpha-MSH were measured by enzyme-linked immunosorbent assay technique. Results: Mean ejection fraction was 56.7 ± 9.6%. Alpha-MSH similarly increased from rest to peak CPET on both modalities. There were no significant differences in alpha-MSH values during testing in patients with 1,2- and 3-vesel CAD, nor in patients with a SYNTAX score </≥ 23 (p > 0.05). Among CPET and hormonal parameters, ∆alpha-MSH recovery/peak during RE CPET was the best predictor of cardiac event occurrence (chi-square 6.67, HR = 0.51, CI = 0.25–1.02, p = 0.010). Conclusion: ∆alpha-MSH recovery/peak during RE CPET has predictive value for CAD prognosis, demonstrating involvement of alpha-MSH in CAD and a link between stress hormones and cardiac events.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "Hormones",
title = "Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease",
volume = "20",
pages = "381-387",
doi = "10.1007/s42000-020-00270-2"
}

Vidojević, D., Seman, S., Lasica, R., Tešić, M., Sarić-Matutinović, M., Jovičić, S., Ignjatović, S., Arena, R., Damjanović, S.,& Popović, D.. (2021). Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease. in Hormones
Springer Science and Business Media Deutschland GmbH., 20, 381-387.
https://doi.org/10.1007/s42000-020-00270-2

Vidojević D, Seman S, Lasica R, Tešić M, Sarić-Matutinović M, Jovičić S, Ignjatović S, Arena R, Damjanović S, Popović D. Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease. in Hormones. 2021;20:381-387.
doi:10.1007/s42000-020-00270-2 .

Vidojević, Dejana, Seman, Stefan, Lasica, Ratko, Tešić, Milorad, Sarić-Matutinović, Marija, Jovičić, Snežana, Ignjatović, Svetlana, Arena, Ross, Damjanović, Svetozar, Popović, Dejana, "Alpha-melanocyte-stimulating hormone during exercise recovery has prognostic value for coronary artery disease" in Hormones, 20 (2021):381-387,
https://doi.org/10.1007/s42000-020-00270-2 . .