TY  - JOUR
AU  - Šuvakov, Sonja
AU  - Jerotić, D
AU  - Damjanović, Tatjana
AU  - Milić, N
AU  - Pekmezović, T
AU  - Đukić, Tatjana
AU  - Jelić-Ivanović, Zorana
AU  - Savić-Radojević, Ana
AU  - Pljesa-Ercegovac, Marija
AU  - Matić, Marija
AU  - McClements, L
AU  - Dimković, Nada
AU  - Garović, V.D
AU  - Albright, R.C
AU  - Simić, Tatjana
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3277
AB  - Introduction: Overall survival of patients with end-stage renal disease (ESRD) remains poor. Oxidative stress is one of the major risk factors associated with mortality in this patient group. As glutathione S-transferases (GST) are well-established antioxidants, we hypothesized that a model including GST gene polymorphisms, oxidative damage byproducts and cell adhesion markers has a prognostic role in ESRD patient survival. Methods: A prospective study of 199 patients with ESRD on haemodialysis was conducted. GST genotype, oxidative stress byproducts and cell adhesion molecules were measured in plasma. Multivariate Cox regression and Kaplan-Meier survival analyses were performed to test the predictive ability of these parameters in the 8-year follow-up period. Results: GSTM1-null genotype was associated with significantly shorter overall (HR 1.6, p = 0.018) and cardiovascular-specific (HR 2.1, p = 0.010) survival. Oxidative stress byproducts (advanced oxidation protein products [AOPP], prooxidant-antioxidant balance [PAB], malondialdehyde [MDA]) and cell adhesion molecules (soluble vascular cell adhesion molecule-1 [sVCAM-1] and soluble intercellular adhesion molecule-1 [sICAM-1]) demonstrated a significant predictive role in terms of overall and cardiovascular survival. When 6 biomarkers (GSTM1 genotype, high AOPP/PAB/MDA/-sVCAM-1/sICAM-1) were combined into a scoring model, a significantly shorter overall and cardiovascular survival was observed for patients with the highest score (p  lt  0.001). Conclusion: We identified a novel panel of biomarkers that can be utilized in predicting survival in ESRD patients. This biomarker signature could enable better monitoring of patients and stratification into appropriate treatment groups.
PB  - S. Karger AG
T2  - American Journal of Nephrology
T1  - Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival
DO  - 10.1159/000501300
ER  - 

@article{
author = "Šuvakov, Sonja and Jerotić, D and Damjanović, Tatjana and Milić, N and Pekmezović, T and Đukić, Tatjana and Jelić-Ivanović, Zorana and Savić-Radojević, Ana and Pljesa-Ercegovac, Marija and Matić, Marija and McClements, L and Dimković, Nada and Garović, V.D and Albright, R.C and Simić, Tatjana",
year = "2019",
abstract = "Introduction: Overall survival of patients with end-stage renal disease (ESRD) remains poor. Oxidative stress is one of the major risk factors associated with mortality in this patient group. As glutathione S-transferases (GST) are well-established antioxidants, we hypothesized that a model including GST gene polymorphisms, oxidative damage byproducts and cell adhesion markers has a prognostic role in ESRD patient survival. Methods: A prospective study of 199 patients with ESRD on haemodialysis was conducted. GST genotype, oxidative stress byproducts and cell adhesion molecules were measured in plasma. Multivariate Cox regression and Kaplan-Meier survival analyses were performed to test the predictive ability of these parameters in the 8-year follow-up period. Results: GSTM1-null genotype was associated with significantly shorter overall (HR 1.6, p = 0.018) and cardiovascular-specific (HR 2.1, p = 0.010) survival. Oxidative stress byproducts (advanced oxidation protein products [AOPP], prooxidant-antioxidant balance [PAB], malondialdehyde [MDA]) and cell adhesion molecules (soluble vascular cell adhesion molecule-1 [sVCAM-1] and soluble intercellular adhesion molecule-1 [sICAM-1]) demonstrated a significant predictive role in terms of overall and cardiovascular survival. When 6 biomarkers (GSTM1 genotype, high AOPP/PAB/MDA/-sVCAM-1/sICAM-1) were combined into a scoring model, a significantly shorter overall and cardiovascular survival was observed for patients with the highest score (p  lt  0.001). Conclusion: We identified a novel panel of biomarkers that can be utilized in predicting survival in ESRD patients. This biomarker signature could enable better monitoring of patients and stratification into appropriate treatment groups.",
publisher = "S. Karger AG",
journal = "American Journal of Nephrology",
title = "Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival",
doi = "10.1159/000501300"
}

Šuvakov, S., Jerotić, D., Damjanović, T., Milić, N., Pekmezović, T., Đukić, T., Jelić-Ivanović, Z., Savić-Radojević, A., Pljesa-Ercegovac, M., Matić, M., McClements, L., Dimković, N., Garović, V.D, Albright, R.C,& Simić, T.. (2019). Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival. in American Journal of Nephrology
S. Karger AG..
https://doi.org/10.1159/000501300

Šuvakov S, Jerotić D, Damjanović T, Milić N, Pekmezović T, Đukić T, Jelić-Ivanović Z, Savić-Radojević A, Pljesa-Ercegovac M, Matić M, McClements L, Dimković N, Garović V, Albright R, Simić T. Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival. in American Journal of Nephrology. 2019;.
doi:10.1159/000501300 .

Šuvakov, Sonja, Jerotić, D, Damjanović, Tatjana, Milić, N, Pekmezović, T, Đukić, Tatjana, Jelić-Ivanović, Zorana, Savić-Radojević, Ana, Pljesa-Ercegovac, Marija, Matić, Marija, McClements, L, Dimković, Nada, Garović, V.D, Albright, R.C, Simić, Tatjana, "Markers of Oxidative Stress and Endothelial Dysfunction Predict Haemodialysis Patients Survival" in American Journal of Nephrology (2019),
https://doi.org/10.1159/000501300 . .