TY  - JOUR
AU  - Perić, Aleksandar
AU  - Gaćeša, Dejan
AU  - Vezmar-Kovačević, Sandra
AU  - Perić, Aneta V.
AU  - Vojvodić, Danilo
AU  - Georgiou, Stella
AU  - Protopapadakis, Evdokia
AU  - Alevizopoulos, Konstantinos
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5346
AB  - Objective. To investigate epidermal growth factor (EGF), transforming growth factor (TGF)- a and interleukin (IL)-8 production in nasal mucosa irrigated with hypertonic 2.3% solution with algae extracts, in comparison to 0.9% NaCl during the first two weeks after surgery for nasal polyposis (NP), in relation to symptoms and local findings. Methods. This prospective study included 20 NP patients postoperatively irrigated with hypertonic and 20 with isotonic solution. We evaluated symptoms (NSS), endoscopic findings (ES) and mediator levels in nasal secretions before and after irrigation. Results. Following treatment, NSS and ES were significantly lower in the hypertonic solution group (p = 0.023; p < 0.001, respectively). The increase in the EGF and the decrease in the TGF-a and IL-8 concentration were higher in the hypertonic group (p < 0.001 for all mediators). Conclusion. Irrigation with a hypertonic solution was found to be more effective than an isotonic solution in nasal mucosa reparation.
PB  - Cambridge University Press
T2  - Journal of Laryngology and Otology
T1  - The effect of nasal douching by hypertonic 2.3% sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment
DO  - 10.1017/S0022215123001974
ER  - 

@article{
author = "Perić, Aleksandar and Gaćeša, Dejan and Vezmar-Kovačević, Sandra and Perić, Aneta V. and Vojvodić, Danilo and Georgiou, Stella and Protopapadakis, Evdokia and Alevizopoulos, Konstantinos",
year = "2023",
abstract = "Objective. To investigate epidermal growth factor (EGF), transforming growth factor (TGF)- a and interleukin (IL)-8 production in nasal mucosa irrigated with hypertonic 2.3% solution with algae extracts, in comparison to 0.9% NaCl during the first two weeks after surgery for nasal polyposis (NP), in relation to symptoms and local findings. Methods. This prospective study included 20 NP patients postoperatively irrigated with hypertonic and 20 with isotonic solution. We evaluated symptoms (NSS), endoscopic findings (ES) and mediator levels in nasal secretions before and after irrigation. Results. Following treatment, NSS and ES were significantly lower in the hypertonic solution group (p = 0.023; p < 0.001, respectively). The increase in the EGF and the decrease in the TGF-a and IL-8 concentration were higher in the hypertonic group (p < 0.001 for all mediators). Conclusion. Irrigation with a hypertonic solution was found to be more effective than an isotonic solution in nasal mucosa reparation.",
publisher = "Cambridge University Press",
journal = "Journal of Laryngology and Otology",
title = "The effect of nasal douching by hypertonic 2.3% sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment",
doi = "10.1017/S0022215123001974"
}

Perić, A., Gaćeša, D., Vezmar-Kovačević, S., Perić, A. V., Vojvodić, D., Georgiou, S., Protopapadakis, E.,& Alevizopoulos, K.. (2023). The effect of nasal douching by hypertonic 2.3% sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment. in Journal of Laryngology and Otology
Cambridge University Press..
https://doi.org/10.1017/S0022215123001974

Perić A, Gaćeša D, Vezmar-Kovačević S, Perić AV, Vojvodić D, Georgiou S, Protopapadakis E, Alevizopoulos K. The effect of nasal douching by hypertonic 2.3% sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment. in Journal of Laryngology and Otology. 2023;.
doi:10.1017/S0022215123001974 .

Perić, Aleksandar, Gaćeša, Dejan, Vezmar-Kovačević, Sandra, Perić, Aneta V., Vojvodić, Danilo, Georgiou, Stella, Protopapadakis, Evdokia, Alevizopoulos, Konstantinos, "The effect of nasal douching by hypertonic 2.3% sea water with algae extracts on the concentration of epidermal growth factor, transforming growth factor-α and interleukin-8 in nasal secretions of patients with nasal polyposis following endoscopic surgical treatment" in Journal of Laryngology and Otology (2023),
https://doi.org/10.1017/S0022215123001974 . .