TY  - JOUR
AU  - Vučinić, Slavica
AU  - Kilibarda, Vesna
AU  - Đorđević, Snežana
AU  - Đorđević, Dragana
AU  - Perković-Vukcević, Nataša
AU  - Vuković-Ercegović, Gordana
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Antonijević, Evica
AU  - Brajković, Gordana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3196
AB  - A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Tachycardia was established in 53, mydriasis in 31, somnolence, nausea. vomiting, and agitation in 16, dizziness in 10, disorientation in 9, dyspnoea and chest pain in 4, and loss of consciousness, pallor, paraesthesia, muscle twitches, and short-term memory impairment in 2 patients. After receiving symptomatic and supportive treatment in the emergency ward, all patients had fully recovered within 8 h and were discharged shortly afterwards. Another part of the study was focused on the analysis of the products known under their local street names as "Biljni tamjan" (herbal incense), "Beli slez", and "Rainbow Special" and the analysis of urine sampled from the patients with gas chromatography - mass spectrometry, and high performance liquid chromatography. The detected synthetic cannabinoids were AB-PINACA, JWH-018, JWH-122, JWH-210, 5F-AKB48, and MDMB-CHMICA in herbal products and AB-FUBINACA, AB-CHMINACA, and MDMB-CHIvIICA in the urine samples. Our findings have shown the great capacity of NPCC to I) monitor NPS abuse in Serbia, II) reliably detect SCs in illicit products and biological samples, and III) clinically manage the adverse effects in their users. Future commitments of the NPCC will include systematic collection of relevant data on SCs and their adverse effects, detection of changes in purity and composition of the controlled NPS-based products, and raising the public awareness of NPS to improve the effectiveness of the national Early Warning System.
PB  - Inst Medical Research & Occupational Health, Zagreb
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids
VL  - 69
IS  - 2
SP  - 178
EP  - 185
DO  - 10.2478/aiht-2018-69-3096
ER  - 

@article{
author = "Vučinić, Slavica and Kilibarda, Vesna and Đorđević, Snežana and Đorđević, Dragana and Perković-Vukcević, Nataša and Vuković-Ercegović, Gordana and Antonijević, Biljana and Ćurčić, Marijana and Antonijević, Evica and Brajković, Gordana",
year = "2018",
abstract = "A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Tachycardia was established in 53, mydriasis in 31, somnolence, nausea. vomiting, and agitation in 16, dizziness in 10, disorientation in 9, dyspnoea and chest pain in 4, and loss of consciousness, pallor, paraesthesia, muscle twitches, and short-term memory impairment in 2 patients. After receiving symptomatic and supportive treatment in the emergency ward, all patients had fully recovered within 8 h and were discharged shortly afterwards. Another part of the study was focused on the analysis of the products known under their local street names as "Biljni tamjan" (herbal incense), "Beli slez", and "Rainbow Special" and the analysis of urine sampled from the patients with gas chromatography - mass spectrometry, and high performance liquid chromatography. The detected synthetic cannabinoids were AB-PINACA, JWH-018, JWH-122, JWH-210, 5F-AKB48, and MDMB-CHMICA in herbal products and AB-FUBINACA, AB-CHMINACA, and MDMB-CHIvIICA in the urine samples. Our findings have shown the great capacity of NPCC to I) monitor NPS abuse in Serbia, II) reliably detect SCs in illicit products and biological samples, and III) clinically manage the adverse effects in their users. Future commitments of the NPCC will include systematic collection of relevant data on SCs and their adverse effects, detection of changes in purity and composition of the controlled NPS-based products, and raising the public awareness of NPS to improve the effectiveness of the national Early Warning System.",
publisher = "Inst Medical Research & Occupational Health, Zagreb",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids",
volume = "69",
number = "2",
pages = "178-185",
doi = "10.2478/aiht-2018-69-3096"
}

Vučinić, S., Kilibarda, V., Đorđević, S., Đorđević, D., Perković-Vukcević, N., Vuković-Ercegović, G., Antonijević, B., Ćurčić, M., Antonijević, E.,& Brajković, G.. (2018). Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Inst Medical Research & Occupational Health, Zagreb., 69(2), 178-185.
https://doi.org/10.2478/aiht-2018-69-3096

Vučinić S, Kilibarda V, Đorđević S, Đorđević D, Perković-Vukcević N, Vuković-Ercegović G, Antonijević B, Ćurčić M, Antonijević E, Brajković G. Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2018;69(2):178-185.
doi:10.2478/aiht-2018-69-3096 .

Vučinić, Slavica, Kilibarda, Vesna, Đorđević, Snežana, Đorđević, Dragana, Perković-Vukcević, Nataša, Vuković-Ercegović, Gordana, Antonijević, Biljana, Ćurčić, Marijana, Antonijević, Evica, Brajković, Gordana, "Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 69, no. 2 (2018):178-185,
https://doi.org/10.2478/aiht-2018-69-3096 . .

TY  - JOUR
AU  - Đekić, Ljiljana
AU  - Krajišnik, Danina
AU  - Martinović, Martina
AU  - Đorđević, Dragana
AU  - Primorac, Marija
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2468
AB  - Suitability of liquid lecithin (i.e., solution of lecithin in soy bean oil with similar to 60% w/w of phospholipids) for formation of gels, upon addition of water solution of poloxamer 407, was investigated, and formulated systems were evaluated as carriers for percutaneous delivery of ibuprofen. Formulation study of pseudoternary system liquid lecithin/poloxamer 407/water at constant liquid lecithin/poloxamer 407 mass ratio (2.0) revealed that minimum concentrations of liquid lecithin and poloxamer 407 required for formation of gel like systems were 15.75% w/w and 13.13% w/w, respectively, while the maximum content of water was 60.62% w/w. The systems comprising water concentrations in a range from 55 to 60.62% w/w were soft semisolids suitable for topical application, and they were selected for physicochemical and biopharmaceutical evaluation. Analysis of conductivity results and light microscopy examination revealed that investigated systems were water dilutable dispersions of spherical oligolamellar associates of phospholipids and triglyceride molecules in the copolymer water solution. Rheological behavior evaluation results indicated that the investigated gels were thermosensitive shear thinning systems. Ibuprofen (5% w/w) was incorporated by dispersing into the previously prepared carriers. Drug-loaded systems were physically stable at storage temperature from 5 +/- 3 degrees C to 40 +/- 2 degrees C, for 30 days. In vitro ibuprofen release was in accordance with the Higuchi model (r(H) > 0.95) and sustained for 12 h. The obtained results implicated that formulated LLPBGs, optimized regarding drug release and organoleptic properties, represent promising carriers for sustained percutaneous drug delivery of poorly soluble drugs.
PB  - Elsevier Science BV, Amsterdam
T2  - International Journal of Pharmaceutics
T1  - Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen
VL  - 490
IS  - 1-2
SP  - 180
EP  - 189
DO  - 10.1016/j.ijpharm.2015.05.040
ER  - 

@article{
author = "Đekić, Ljiljana and Krajišnik, Danina and Martinović, Martina and Đorđević, Dragana and Primorac, Marija",
year = "2015",
abstract = "Suitability of liquid lecithin (i.e., solution of lecithin in soy bean oil with similar to 60% w/w of phospholipids) for formation of gels, upon addition of water solution of poloxamer 407, was investigated, and formulated systems were evaluated as carriers for percutaneous delivery of ibuprofen. Formulation study of pseudoternary system liquid lecithin/poloxamer 407/water at constant liquid lecithin/poloxamer 407 mass ratio (2.0) revealed that minimum concentrations of liquid lecithin and poloxamer 407 required for formation of gel like systems were 15.75% w/w and 13.13% w/w, respectively, while the maximum content of water was 60.62% w/w. The systems comprising water concentrations in a range from 55 to 60.62% w/w were soft semisolids suitable for topical application, and they were selected for physicochemical and biopharmaceutical evaluation. Analysis of conductivity results and light microscopy examination revealed that investigated systems were water dilutable dispersions of spherical oligolamellar associates of phospholipids and triglyceride molecules in the copolymer water solution. Rheological behavior evaluation results indicated that the investigated gels were thermosensitive shear thinning systems. Ibuprofen (5% w/w) was incorporated by dispersing into the previously prepared carriers. Drug-loaded systems were physically stable at storage temperature from 5 +/- 3 degrees C to 40 +/- 2 degrees C, for 30 days. In vitro ibuprofen release was in accordance with the Higuchi model (r(H) > 0.95) and sustained for 12 h. The obtained results implicated that formulated LLPBGs, optimized regarding drug release and organoleptic properties, represent promising carriers for sustained percutaneous drug delivery of poorly soluble drugs.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen",
volume = "490",
number = "1-2",
pages = "180-189",
doi = "10.1016/j.ijpharm.2015.05.040"
}

Đekić, L., Krajišnik, D., Martinović, M., Đorđević, D.,& Primorac, M.. (2015). Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen. in International Journal of Pharmaceutics
Elsevier Science BV, Amsterdam., 490(1-2), 180-189.
https://doi.org/10.1016/j.ijpharm.2015.05.040

Đekić L, Krajišnik D, Martinović M, Đorđević D, Primorac M. Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen. in International Journal of Pharmaceutics. 2015;490(1-2):180-189.
doi:10.1016/j.ijpharm.2015.05.040 .

Đekić, Ljiljana, Krajišnik, Danina, Martinović, Martina, Đorđević, Dragana, Primorac, Marija, "Characterization of gelation process and drug release profile of thermosensitive liquid lecithin/poloxamer 407 based gels as carriers for percutaneous delivery of ibuprofen" in International Journal of Pharmaceutics, 490, no. 1-2 (2015):180-189,
https://doi.org/10.1016/j.ijpharm.2015.05.040 . .