TY  - JOUR
AU  - Vučinić, Slavica
AU  - Kilibarda, Vesna
AU  - Đorđević, Snežana
AU  - Đorđević, Dragana
AU  - Perković-Vukcević, Nataša
AU  - Vuković-Ercegović, Gordana
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Antonijević, Evica
AU  - Brajković, Gordana
PY  - 2018
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3196
AB  - A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Tachycardia was established in 53, mydriasis in 31, somnolence, nausea. vomiting, and agitation in 16, dizziness in 10, disorientation in 9, dyspnoea and chest pain in 4, and loss of consciousness, pallor, paraesthesia, muscle twitches, and short-term memory impairment in 2 patients. After receiving symptomatic and supportive treatment in the emergency ward, all patients had fully recovered within 8 h and were discharged shortly afterwards. Another part of the study was focused on the analysis of the products known under their local street names as "Biljni tamjan" (herbal incense), "Beli slez", and "Rainbow Special" and the analysis of urine sampled from the patients with gas chromatography - mass spectrometry, and high performance liquid chromatography. The detected synthetic cannabinoids were AB-PINACA, JWH-018, JWH-122, JWH-210, 5F-AKB48, and MDMB-CHMICA in herbal products and AB-FUBINACA, AB-CHMINACA, and MDMB-CHIvIICA in the urine samples. Our findings have shown the great capacity of NPCC to I) monitor NPS abuse in Serbia, II) reliably detect SCs in illicit products and biological samples, and III) clinically manage the adverse effects in their users. Future commitments of the NPCC will include systematic collection of relevant data on SCs and their adverse effects, detection of changes in purity and composition of the controlled NPS-based products, and raising the public awareness of NPS to improve the effectiveness of the national Early Warning System.
PB  - Inst Medical Research & Occupational Health, Zagreb
T2  - Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
T1  - Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids
VL  - 69
IS  - 2
SP  - 178
EP  - 185
DO  - 10.2478/aiht-2018-69-3096
ER  - 

@article{
author = "Vučinić, Slavica and Kilibarda, Vesna and Đorđević, Snežana and Đorđević, Dragana and Perković-Vukcević, Nataša and Vuković-Ercegović, Gordana and Antonijević, Biljana and Ćurčić, Marijana and Antonijević, Evica and Brajković, Gordana",
year = "2018",
abstract = "A rising number of patients are being treated for overdosing with new psychoactive substances (NPS) available at the illegal drug market in Serbia. The aim of this study was to report clinical and analytical experience of the National Poison Control Centre of Serbia (NPCC) with synthetic cannabinoids (SCs) and point to the NPS available at the illegal drug market in our country. From January 2013 to December 2016, 58 patients (aged between 14 and 25) were treated for the effects of synthetic cannabinoids at the NPCC. Tachycardia was established in 53, mydriasis in 31, somnolence, nausea. vomiting, and agitation in 16, dizziness in 10, disorientation in 9, dyspnoea and chest pain in 4, and loss of consciousness, pallor, paraesthesia, muscle twitches, and short-term memory impairment in 2 patients. After receiving symptomatic and supportive treatment in the emergency ward, all patients had fully recovered within 8 h and were discharged shortly afterwards. Another part of the study was focused on the analysis of the products known under their local street names as "Biljni tamjan" (herbal incense), "Beli slez", and "Rainbow Special" and the analysis of urine sampled from the patients with gas chromatography - mass spectrometry, and high performance liquid chromatography. The detected synthetic cannabinoids were AB-PINACA, JWH-018, JWH-122, JWH-210, 5F-AKB48, and MDMB-CHMICA in herbal products and AB-FUBINACA, AB-CHMINACA, and MDMB-CHIvIICA in the urine samples. Our findings have shown the great capacity of NPCC to I) monitor NPS abuse in Serbia, II) reliably detect SCs in illicit products and biological samples, and III) clinically manage the adverse effects in their users. Future commitments of the NPCC will include systematic collection of relevant data on SCs and their adverse effects, detection of changes in purity and composition of the controlled NPS-based products, and raising the public awareness of NPS to improve the effectiveness of the national Early Warning System.",
publisher = "Inst Medical Research & Occupational Health, Zagreb",
journal = "Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology",
title = "Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids",
volume = "69",
number = "2",
pages = "178-185",
doi = "10.2478/aiht-2018-69-3096"
}

Vučinić, S., Kilibarda, V., Đorđević, S., Đorđević, D., Perković-Vukcević, N., Vuković-Ercegović, G., Antonijević, B., Ćurčić, M., Antonijević, E.,& Brajković, G.. (2018). Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology
Inst Medical Research & Occupational Health, Zagreb., 69(2), 178-185.
https://doi.org/10.2478/aiht-2018-69-3096

Vučinić S, Kilibarda V, Đorđević S, Đorđević D, Perković-Vukcević N, Vuković-Ercegović G, Antonijević B, Ćurčić M, Antonijević E, Brajković G. Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids. in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology. 2018;69(2):178-185.
doi:10.2478/aiht-2018-69-3096 .

Vučinić, Slavica, Kilibarda, Vesna, Đorđević, Snežana, Đorđević, Dragana, Perković-Vukcević, Nataša, Vuković-Ercegović, Gordana, Antonijević, Biljana, Ćurčić, Marijana, Antonijević, Evica, Brajković, Gordana, "Clinical and analytical experience of the National Poison Control Centre with synthetic cannabinoids" in Arhiv za higijenu rada i toksikologiju - Archives of Industrial Hygiene and Toxicology, 69, no. 2 (2018):178-185,
https://doi.org/10.2478/aiht-2018-69-3096 . .

TY  - CONF
AU  - Brajković, Gordana
AU  - Jović-Stošić, Jasmina
AU  - Đorđević, Snežana
AU  - Kilibarda, Vesna
AU  - Ćurčić, Marijana
AU  - Radosavljević-Stevanović, Nataša
AU  - Brajković, Zorica
AU  - Vučinić, Slavica
PY  - 2017
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2890
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Determination of JWH-210, JWH-122 and JWH-081 in urine by Liquid Chromatography Mass Spectrometric method
VL  - 280
IS  - Supplement 1
SP  - S292
EP  - S292
DO  - 10.1016/j.toxlet.2017.07.820
ER  - 

@conference{
author = "Brajković, Gordana and Jović-Stošić, Jasmina and Đorđević, Snežana and Kilibarda, Vesna and Ćurčić, Marijana and Radosavljević-Stevanović, Nataša and Brajković, Zorica and Vučinić, Slavica",
year = "2017",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Determination of JWH-210, JWH-122 and JWH-081 in urine by Liquid Chromatography Mass Spectrometric method",
volume = "280",
number = "Supplement 1",
pages = "S292-S292",
doi = "10.1016/j.toxlet.2017.07.820"
}

Brajković, G., Jović-Stošić, J., Đorđević, S., Kilibarda, V., Ćurčić, M., Radosavljević-Stevanović, N., Brajković, Z.,& Vučinić, S.. (2017). Determination of JWH-210, JWH-122 and JWH-081 in urine by Liquid Chromatography Mass Spectrometric method. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 280(Supplement 1), S292-S292.
https://doi.org/10.1016/j.toxlet.2017.07.820

Brajković G, Jović-Stošić J, Đorđević S, Kilibarda V, Ćurčić M, Radosavljević-Stevanović N, Brajković Z, Vučinić S. Determination of JWH-210, JWH-122 and JWH-081 in urine by Liquid Chromatography Mass Spectrometric method. in Toxicology Letters. 2017;280(Supplement 1):S292-S292.
doi:10.1016/j.toxlet.2017.07.820 .

Brajković, Gordana, Jović-Stošić, Jasmina, Đorđević, Snežana, Kilibarda, Vesna, Ćurčić, Marijana, Radosavljević-Stevanović, Nataša, Brajković, Zorica, Vučinić, Slavica, "Determination of JWH-210, JWH-122 and JWH-081 in urine by Liquid Chromatography Mass Spectrometric method" in Toxicology Letters, 280, no. Supplement 1 (2017):S292-S292,
https://doi.org/10.1016/j.toxlet.2017.07.820 . .

TY  - CONF
AU  - Đorđević, S.
AU  - Antunović, M.
AU  - Kilibarda, Vesna
AU  - Brajković, Gordana
AU  - Ćurčić, Marijana
AU  - Jović-Stošić, Jasmina
AU  - Vučinić, Slavica
PY  - 2016
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2644
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Abusing of psychoactive substance in 2015-National Poison Control Center Serbia Data
VL  - 258
SP  - S104
EP  - S105
DO  - 10.1016/j.toxlet.2016.06.1440
ER  - 

@conference{
author = "Đorđević, S. and Antunović, M. and Kilibarda, Vesna and Brajković, Gordana and Ćurčić, Marijana and Jović-Stošić, Jasmina and Vučinić, Slavica",
year = "2016",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Abusing of psychoactive substance in 2015-National Poison Control Center Serbia Data",
volume = "258",
pages = "S104-S105",
doi = "10.1016/j.toxlet.2016.06.1440"
}

Đorđević, S., Antunović, M., Kilibarda, V., Brajković, G., Ćurčić, M., Jović-Stošić, J.,& Vučinić, S.. (2016). Abusing of psychoactive substance in 2015-National Poison Control Center Serbia Data. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 258, S104-S105.
https://doi.org/10.1016/j.toxlet.2016.06.1440

Đorđević S, Antunović M, Kilibarda V, Brajković G, Ćurčić M, Jović-Stošić J, Vučinić S. Abusing of psychoactive substance in 2015-National Poison Control Center Serbia Data. in Toxicology Letters. 2016;258:S104-S105.
doi:10.1016/j.toxlet.2016.06.1440 .

Đorđević, S., Antunović, M., Kilibarda, Vesna, Brajković, Gordana, Ćurčić, Marijana, Jović-Stošić, Jasmina, Vučinić, Slavica, "Abusing of psychoactive substance in 2015-National Poison Control Center Serbia Data" in Toxicology Letters, 258 (2016):S104-S105,
https://doi.org/10.1016/j.toxlet.2016.06.1440 . .

TY  - CONF
AU  - Vučinić, Slavica
AU  - Kilibarda, Vesna
AU  - Jović-Stošić, Jasmina
AU  - Jovanović, M.
AU  - Antonijević, Biljana
AU  - Antonijević, Evica
AU  - Brajković, Gordana
PY  - 2015
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2371
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions
VL  - 238
IS  - 2, Supplement
SP  - S145
EP  - S145
DO  - 10.1016/j.toxlet.2015.08.456
ER  - 

@conference{
author = "Vučinić, Slavica and Kilibarda, Vesna and Jović-Stošić, Jasmina and Jovanović, M. and Antonijević, Biljana and Antonijević, Evica and Brajković, Gordana",
year = "2015",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions",
volume = "238",
number = "2, Supplement",
pages = "S145-S145",
doi = "10.1016/j.toxlet.2015.08.456"
}

Vučinić, S., Kilibarda, V., Jović-Stošić, J., Jovanović, M., Antonijević, B., Antonijević, E.,& Brajković, G.. (2015). Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 238(2, Supplement), S145-S145.
https://doi.org/10.1016/j.toxlet.2015.08.456

Vučinić S, Kilibarda V, Jović-Stošić J, Jovanović M, Antonijević B, Antonijević E, Brajković G. Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions. in Toxicology Letters. 2015;238(2, Supplement):S145-S145.
doi:10.1016/j.toxlet.2015.08.456 .

Vučinić, Slavica, Kilibarda, Vesna, Jović-Stošić, Jasmina, Jovanović, M., Antonijević, Biljana, Antonijević, Evica, Brajković, Gordana, "Dramatic increase of "Herbal incense" and "Sharp Blueberry" users: Clinical patterns, analytical data and the impact to regulatory actions" in Toxicology Letters, 238, no. 2, Supplement (2015):S145-S145,
https://doi.org/10.1016/j.toxlet.2015.08.456 . .

TY  - JOUR
AU  - Joksimović, Srđan
AU  - Divljaković, Jovana
AU  - van Linn, Michael
AU  - Varagić, Zdravko
AU  - Brajković, Gordana
AU  - Milinković, Marija M.
AU  - Yin, Wenyuan
AU  - Timić, Tamara
AU  - Sieghart, Werner
AU  - Cook, James M.
AU  - Savić, Miroslav
PY  - 2013
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/2028
AB  - Despite significant advances in understanding the role of benzodiazepine (BZ)-sensitive populations of GABA A receptors, containing the α 1 , α 2 , α 3 or α 5 subunit, factual substrates of BZ-induced learning and memory deficits are not yet fully elucidated. It was shown that α 1 -subunit affinity-selective antagonist Β-CCt almost completely abolished spatial learning deficits induced by diazepam (DZP) in the Morris water maze. We examined a novel, highly (105 fold) α 1 -subunit selective ligand-WYS8 (0.2, 1 and 10mg/kg), on its own and in combination with the non-selective agonist DZP (2mg/kg) or Β-CCt (5mg/kg) in the water maze in rats. The in vitro efficacy study revealed that WYS8 acts as α 1 -subtype selective weak partial positive modulator (40% potentiation at 100nM). Measurement of concentrations of WYS8 and DZP in rat serum and brain tissues suggested that they did not substantially cross-influence the respective disposition. In the water maze, DZP impaired spatial learning (acquisition trials) and memory (probe trial). WYS8 caused no effect per se, did not affect the overall influence of DZP on the water-maze performance and was devoid of any activity in this task when combined with Β-CCt. Nonetheless, an additional analysis of the latency to reach the platform and the total distance swam suggested that WYS8 addition attenuated the run-down of the spatial impairment induced by DZP at the end of acquisition trials. These results demonstrate a clear difference in the influence of an α 1 subtype-selective antagonist and a partial agonist on the effects of DZP on the water-maze acquisition.
T2  - European Neuropsychopharmacology
T1  - Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α 1 GABA A receptors
VL  - 23
IS  - 5
SP  - 390
EP  - 399
DO  - 10.1016/j.euroneuro.2012.05.003
ER  - 

@article{
author = "Joksimović, Srđan and Divljaković, Jovana and van Linn, Michael and Varagić, Zdravko and Brajković, Gordana and Milinković, Marija M. and Yin, Wenyuan and Timić, Tamara and Sieghart, Werner and Cook, James M. and Savić, Miroslav",
year = "2013",
abstract = "Despite significant advances in understanding the role of benzodiazepine (BZ)-sensitive populations of GABA A receptors, containing the α 1 , α 2 , α 3 or α 5 subunit, factual substrates of BZ-induced learning and memory deficits are not yet fully elucidated. It was shown that α 1 -subunit affinity-selective antagonist Β-CCt almost completely abolished spatial learning deficits induced by diazepam (DZP) in the Morris water maze. We examined a novel, highly (105 fold) α 1 -subunit selective ligand-WYS8 (0.2, 1 and 10mg/kg), on its own and in combination with the non-selective agonist DZP (2mg/kg) or Β-CCt (5mg/kg) in the water maze in rats. The in vitro efficacy study revealed that WYS8 acts as α 1 -subtype selective weak partial positive modulator (40% potentiation at 100nM). Measurement of concentrations of WYS8 and DZP in rat serum and brain tissues suggested that they did not substantially cross-influence the respective disposition. In the water maze, DZP impaired spatial learning (acquisition trials) and memory (probe trial). WYS8 caused no effect per se, did not affect the overall influence of DZP on the water-maze performance and was devoid of any activity in this task when combined with Β-CCt. Nonetheless, an additional analysis of the latency to reach the platform and the total distance swam suggested that WYS8 addition attenuated the run-down of the spatial impairment induced by DZP at the end of acquisition trials. These results demonstrate a clear difference in the influence of an α 1 subtype-selective antagonist and a partial agonist on the effects of DZP on the water-maze acquisition.",
journal = "European Neuropsychopharmacology",
title = "Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α 1 GABA A receptors",
volume = "23",
number = "5",
pages = "390-399",
doi = "10.1016/j.euroneuro.2012.05.003"
}

Joksimović, S., Divljaković, J., van Linn, M., Varagić, Z., Brajković, G., Milinković, M. M., Yin, W., Timić, T., Sieghart, W., Cook, J. M.,& Savić, M.. (2013). Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α 1 GABA A receptors. in European Neuropsychopharmacology, 23(5), 390-399.
https://doi.org/10.1016/j.euroneuro.2012.05.003

Joksimović S, Divljaković J, van Linn M, Varagić Z, Brajković G, Milinković MM, Yin W, Timić T, Sieghart W, Cook JM, Savić M. Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α 1 GABA A receptors. in European Neuropsychopharmacology. 2013;23(5):390-399.
doi:10.1016/j.euroneuro.2012.05.003 .

Joksimović, Srđan, Divljaković, Jovana, van Linn, Michael, Varagić, Zdravko, Brajković, Gordana, Milinković, Marija M., Yin, Wenyuan, Timić, Tamara, Sieghart, Werner, Cook, James M., Savić, Miroslav, "Benzodiazepine-induced spatial learning deficits in rats are regulated by the degree of modulation of α 1 GABA A receptors" in European Neuropsychopharmacology, 23, no. 5 (2013):390-399,
https://doi.org/10.1016/j.euroneuro.2012.05.003 . .