TY  - JOUR
AU  - Ražić, Slavica
AU  - Gadžurić, Slobodan
AU  - Trtić-Petrović, Tatjana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5299
AB  - The widespread use of ionic liquids (ILs) as greener solvents in analytical sciences, especially in sample pretreatment, has focused attention on exploiting their enormous potential, not only on eliminating and improving the drawbacks faced by scientists. These ionic compounds with unique physicochemical properties can be tuned through smart synthesis, combining cations and anions, so that the compound exhibits excellent properties for its intended purpose. Ionic liquids are rightly referred to as designer solvents. Validation of a newly proposed analytical methods using ionic liquids, either in sample preparation or in further analysis, is a critical process to demonstrate that a particular analytical method is fit for purpose and provides reliable and accurate results. In addition, this article specially addressed the potential toxicity of ionic liquids with the modest goal of assisting researchers in this field by expanding their target areas. Graphical Abstract: [Figure not available: see fulltext.].
PB  - Springer Nature
T2  - Analytical and Bioanalytical Chemistry
T1  - Ionic liquids in green analytical chemistry—are they that good and green enough?
DO  - 10.1007/s00216-023-05045-3
ER  - 

@article{
author = "Ražić, Slavica and Gadžurić, Slobodan and Trtić-Petrović, Tatjana",
year = "2023",
abstract = "The widespread use of ionic liquids (ILs) as greener solvents in analytical sciences, especially in sample pretreatment, has focused attention on exploiting their enormous potential, not only on eliminating and improving the drawbacks faced by scientists. These ionic compounds with unique physicochemical properties can be tuned through smart synthesis, combining cations and anions, so that the compound exhibits excellent properties for its intended purpose. Ionic liquids are rightly referred to as designer solvents. Validation of a newly proposed analytical methods using ionic liquids, either in sample preparation or in further analysis, is a critical process to demonstrate that a particular analytical method is fit for purpose and provides reliable and accurate results. In addition, this article specially addressed the potential toxicity of ionic liquids with the modest goal of assisting researchers in this field by expanding their target areas. Graphical Abstract: [Figure not available: see fulltext.].",
publisher = "Springer Nature",
journal = "Analytical and Bioanalytical Chemistry",
title = "Ionic liquids in green analytical chemistry—are they that good and green enough?",
doi = "10.1007/s00216-023-05045-3"
}

Ražić, S., Gadžurić, S.,& Trtić-Petrović, T.. (2023). Ionic liquids in green analytical chemistry—are they that good and green enough?. in Analytical and Bioanalytical Chemistry
Springer Nature..
https://doi.org/10.1007/s00216-023-05045-3

Ražić S, Gadžurić S, Trtić-Petrović T. Ionic liquids in green analytical chemistry—are they that good and green enough?. in Analytical and Bioanalytical Chemistry. 2023;.
doi:10.1007/s00216-023-05045-3 .

Ražić, Slavica, Gadžurić, Slobodan, Trtić-Petrović, Tatjana, "Ionic liquids in green analytical chemistry—are they that good and green enough?" in Analytical and Bioanalytical Chemistry (2023),
https://doi.org/10.1007/s00216-023-05045-3 . .

TY  - JOUR
AU  - Ražić, Slavica
AU  - Arsenijević, Jelena
AU  - Đogo-Mračević, Svetlana
AU  - Mušović, Jasmina
AU  - Trtić-Petrović, Tatjana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4920
AB  - More environment-friendly solvents in analytical chemistry are almost inevitable in both sample preparation and analysis to meet the high standards of sustainable chemistry and human welfare. In this review paper, a critical look at the advantages and still unsolved problems of most potential classes of green solvents is presented to give an overview of the current state-of-the-art in this field. Replacing volatile organic compounds (VOCs) by ecofriendly and benign solvents in extractions/separations in sample preparation, as the most tedious and demanding step in analysis, is one of roads toward sustainable chemistry. Water under sub- and supercritical conditions, carbon-dioxide, ionic liquids (ILs), deep eutectic solvents (DESs), and those of natural origin (NADES) belong to the most promising classes of solvents in green analytical chemistry. Basic theory and mechanisms of their use illustrated by representative but not exhaustive list of examples related to complex matrices (environmental and natural food products) from analytical practice are presented in this review. Perspectives of QuEChERS, in line with GAC principles, are highlighted, in line with current trends of “going green” for quick, easy, cheap, effective, rugged, and safe analytical methods. Compliance with green chemistry (GC), especially green analytical chemistry (GAC) principles, is not a fashionable issue but, more the trend toward a sustainable future with greener chemistry; thus, green metrics are an unavoidable tool to measure how green the applied method or procedure is. Herein, the most common tools will be presented and discussed, such as national environmental method index (NEMI), analytical ecoscale, green analytical procedure index (GAPI), analytical greenness calculator (AGREE), complementary green analytical procedure index (ComplexGAPI), and analytical greenness metric for sample preparation (AGREEprep). The future trends for research and development in this still expanding field are presented in a critical view of advantages and disadvantages as well as improvement of the validation of analytical procedures. The creation of new certified reference materials (CRMs) and validated methods for specified analytes in complex matrices is a demanding task in the coming years. Tailor-made solvents with physicochemical properties for intended use are required for the selective extraction and separation and open numerous possibilities and huge potential for future research and industrial applications.
PB  - Royal Society of Chemistry
T2  - Analyst
T1  - Greener chemistry in analytical sciences: from green solvents to applications in complex matrices. Current challenges and future perspectives: a critical review
DO  - 10.1039/d3an00498h
ER  - 

@article{
author = "Ražić, Slavica and Arsenijević, Jelena and Đogo-Mračević, Svetlana and Mušović, Jasmina and Trtić-Petrović, Tatjana",
year = "2023",
abstract = "More environment-friendly solvents in analytical chemistry are almost inevitable in both sample preparation and analysis to meet the high standards of sustainable chemistry and human welfare. In this review paper, a critical look at the advantages and still unsolved problems of most potential classes of green solvents is presented to give an overview of the current state-of-the-art in this field. Replacing volatile organic compounds (VOCs) by ecofriendly and benign solvents in extractions/separations in sample preparation, as the most tedious and demanding step in analysis, is one of roads toward sustainable chemistry. Water under sub- and supercritical conditions, carbon-dioxide, ionic liquids (ILs), deep eutectic solvents (DESs), and those of natural origin (NADES) belong to the most promising classes of solvents in green analytical chemistry. Basic theory and mechanisms of their use illustrated by representative but not exhaustive list of examples related to complex matrices (environmental and natural food products) from analytical practice are presented in this review. Perspectives of QuEChERS, in line with GAC principles, are highlighted, in line with current trends of “going green” for quick, easy, cheap, effective, rugged, and safe analytical methods. Compliance with green chemistry (GC), especially green analytical chemistry (GAC) principles, is not a fashionable issue but, more the trend toward a sustainable future with greener chemistry; thus, green metrics are an unavoidable tool to measure how green the applied method or procedure is. Herein, the most common tools will be presented and discussed, such as national environmental method index (NEMI), analytical ecoscale, green analytical procedure index (GAPI), analytical greenness calculator (AGREE), complementary green analytical procedure index (ComplexGAPI), and analytical greenness metric for sample preparation (AGREEprep). The future trends for research and development in this still expanding field are presented in a critical view of advantages and disadvantages as well as improvement of the validation of analytical procedures. The creation of new certified reference materials (CRMs) and validated methods for specified analytes in complex matrices is a demanding task in the coming years. Tailor-made solvents with physicochemical properties for intended use are required for the selective extraction and separation and open numerous possibilities and huge potential for future research and industrial applications.",
publisher = "Royal Society of Chemistry",
journal = "Analyst",
title = "Greener chemistry in analytical sciences: from green solvents to applications in complex matrices. Current challenges and future perspectives: a critical review",
doi = "10.1039/d3an00498h"
}

Ražić, S., Arsenijević, J., Đogo-Mračević, S., Mušović, J.,& Trtić-Petrović, T.. (2023). Greener chemistry in analytical sciences: from green solvents to applications in complex matrices. Current challenges and future perspectives: a critical review. in Analyst
Royal Society of Chemistry..
https://doi.org/10.1039/d3an00498h

Ražić S, Arsenijević J, Đogo-Mračević S, Mušović J, Trtić-Petrović T. Greener chemistry in analytical sciences: from green solvents to applications in complex matrices. Current challenges and future perspectives: a critical review. in Analyst. 2023;.
doi:10.1039/d3an00498h .

Ražić, Slavica, Arsenijević, Jelena, Đogo-Mračević, Svetlana, Mušović, Jasmina, Trtić-Petrović, Tatjana, "Greener chemistry in analytical sciences: from green solvents to applications in complex matrices. Current challenges and future perspectives: a critical review" in Analyst (2023),
https://doi.org/10.1039/d3an00498h . .

TY  - JOUR
AU  - Mušović, Jasmina
AU  - Vraneš, Milan
AU  - Papović, Snežana
AU  - Gadžurić, Slobodan
AU  - Ražić, Slavica
AU  - Trtić-Petrović, Tatjana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4382
AB  - Although sample preparation, as an unavoidable step of the analytical process should be simple, it is very often identified as a bottleneck. Simplicity of sample preparation based on cost-effective and non-hazardous materials is mandatory for any sustainable and environmental friendly approach. Aqueous biphasic systems (ABS), based on functionalized ionic liquids (FILs) are acceptable alternatives to classical extraction procedures, due to the replacement of organic solvent with diluted aqueous-soluble ionic liquids. In this work, two water soluble FILs based on 2-mercaptobenzothiazolate anion, [mbt]: 1-butyl-3-methylimidazolium [mbt] ([bmim][mbt]) and 1-ethyl-3-methylimidazolium [mbt] ([emim][mbt]), were designed and synthesized in order to selectively extract Cd(II) and Pb(II) from the river sediment. It was found that [mbt]– anion acts as the ligand and forms complexes with Cd(II) and Pb(II) which are responsible for their efficient extraction, while cation is more responsible for the formation of ABS. Partition coefficients of 408 and 180 for Cd(II) and Pb(II), respectively, were obtained using ABS based on [bmim][mbt]. Direct extraction of Cd(II) and Pb(II) from the river sediment has been investigated and obtained optimal conditions are: 60 min direct contact of the aqueous solution of [bmim][mbt] and the sediment sample at 90 °C, followed by formation of ABS upon addition of potassium citrate. Using AGRE and AGREEprep tools greenness of the proposed method for direct extraction of Cd(II) and Pb(II) from the sediment are calculated. Obtained values of 0.69 and 0.71 for Cd(II) and Pb(II) extraction, respectively, showed a high level of the greenness of the proposed method.
PB  - Elsevier B.V.
T2  - Journal of Molecular Liquids
T1  - Greener sample preparation method for direct determination of Cd(II) and Pb(II) in river sediment based on an aqueous biphasic system with functionalized ionic liquids
VL  - 369
DO  - 10.1016/j.molliq.2022.120974
ER  - 

@article{
author = "Mušović, Jasmina and Vraneš, Milan and Papović, Snežana and Gadžurić, Slobodan and Ražić, Slavica and Trtić-Petrović, Tatjana",
year = "2023",
abstract = "Although sample preparation, as an unavoidable step of the analytical process should be simple, it is very often identified as a bottleneck. Simplicity of sample preparation based on cost-effective and non-hazardous materials is mandatory for any sustainable and environmental friendly approach. Aqueous biphasic systems (ABS), based on functionalized ionic liquids (FILs) are acceptable alternatives to classical extraction procedures, due to the replacement of organic solvent with diluted aqueous-soluble ionic liquids. In this work, two water soluble FILs based on 2-mercaptobenzothiazolate anion, [mbt]: 1-butyl-3-methylimidazolium [mbt] ([bmim][mbt]) and 1-ethyl-3-methylimidazolium [mbt] ([emim][mbt]), were designed and synthesized in order to selectively extract Cd(II) and Pb(II) from the river sediment. It was found that [mbt]– anion acts as the ligand and forms complexes with Cd(II) and Pb(II) which are responsible for their efficient extraction, while cation is more responsible for the formation of ABS. Partition coefficients of 408 and 180 for Cd(II) and Pb(II), respectively, were obtained using ABS based on [bmim][mbt]. Direct extraction of Cd(II) and Pb(II) from the river sediment has been investigated and obtained optimal conditions are: 60 min direct contact of the aqueous solution of [bmim][mbt] and the sediment sample at 90 °C, followed by formation of ABS upon addition of potassium citrate. Using AGRE and AGREEprep tools greenness of the proposed method for direct extraction of Cd(II) and Pb(II) from the sediment are calculated. Obtained values of 0.69 and 0.71 for Cd(II) and Pb(II) extraction, respectively, showed a high level of the greenness of the proposed method.",
publisher = "Elsevier B.V.",
journal = "Journal of Molecular Liquids",
title = "Greener sample preparation method for direct determination of Cd(II) and Pb(II) in river sediment based on an aqueous biphasic system with functionalized ionic liquids",
volume = "369",
doi = "10.1016/j.molliq.2022.120974"
}

Mušović, J., Vraneš, M., Papović, S., Gadžurić, S., Ražić, S.,& Trtić-Petrović, T.. (2023). Greener sample preparation method for direct determination of Cd(II) and Pb(II) in river sediment based on an aqueous biphasic system with functionalized ionic liquids. in Journal of Molecular Liquids
Elsevier B.V.., 369.
https://doi.org/10.1016/j.molliq.2022.120974

Mušović J, Vraneš M, Papović S, Gadžurić S, Ražić S, Trtić-Petrović T. Greener sample preparation method for direct determination of Cd(II) and Pb(II) in river sediment based on an aqueous biphasic system with functionalized ionic liquids. in Journal of Molecular Liquids. 2023;369.
doi:10.1016/j.molliq.2022.120974 .

Mušović, Jasmina, Vraneš, Milan, Papović, Snežana, Gadžurić, Slobodan, Ražić, Slavica, Trtić-Petrović, Tatjana, "Greener sample preparation method for direct determination of Cd(II) and Pb(II) in river sediment based on an aqueous biphasic system with functionalized ionic liquids" in Journal of Molecular Liquids, 369 (2023),
https://doi.org/10.1016/j.molliq.2022.120974 . .

TY  - CONF
AU  - Arsenijević, Jelena
AU  - Drobac, Milica
AU  - Trtić-Petrović, Tatjana
AU  - Kovačević, Nada
AU  - Ražić, Slavica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5158
PB  - European Chemical Society
C3  - 1st European Sample Preparation e-Conference, March 11-12, 2021, Book of Abstracts
T1  - Green approach to extraction of plant volatiles from herbal teas using ionic liquids
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5158
ER  - 

@conference{
author = "Arsenijević, Jelena and Drobac, Milica and Trtić-Petrović, Tatjana and Kovačević, Nada and Ražić, Slavica",
year = "2021",
publisher = "European Chemical Society",
journal = "1st European Sample Preparation e-Conference, March 11-12, 2021, Book of Abstracts",
title = "Green approach to extraction of plant volatiles from herbal teas using ionic liquids",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5158"
}

Arsenijević, J., Drobac, M., Trtić-Petrović, T., Kovačević, N.,& Ražić, S.. (2021). Green approach to extraction of plant volatiles from herbal teas using ionic liquids. in 1st European Sample Preparation e-Conference, March 11-12, 2021, Book of Abstracts
European Chemical Society..
https://hdl.handle.net/21.15107/rcub_farfar_5158

Arsenijević J, Drobac M, Trtić-Petrović T, Kovačević N, Ražić S. Green approach to extraction of plant volatiles from herbal teas using ionic liquids. in 1st European Sample Preparation e-Conference, March 11-12, 2021, Book of Abstracts. 2021;.
https://hdl.handle.net/21.15107/rcub_farfar_5158 .

Arsenijević, Jelena, Drobac, Milica, Trtić-Petrović, Tatjana, Kovačević, Nada, Ražić, Slavica, "Green approach to extraction of plant volatiles from herbal teas using ionic liquids" in 1st European Sample Preparation e-Conference, March 11-12, 2021, Book of Abstracts (2021),
https://hdl.handle.net/21.15107/rcub_farfar_5158 .

TY  - JOUR
AU  - Culicov, Otilia Ana
AU  - Trtić-Petrović, Tatjana
AU  - Balvanović, Roman
AU  - Petković, Anđelka
AU  - Ražić, Slavica
PY  - 2021
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/3904
AB  - Recent studies show that lanthanides (Ln) are becoming emerging pollutants due to their wide application in new technologies,but their environmental fate, transport, and possible accumulation are still relatively unknown. This study aims to determinemajor and trace elements including Ln in the Danube River sediment which either belong or close to the Iron Gate Reservoir. TheIron Gate Reservoir is characterized by accumulation of sediments as an effect of building hydropower dam Iron Gate I. Thesurface sediments were collected on the Danube River—1141 to 864 km and three tributaries along this waterway. Two samplesof deep sediments were used for comparison. The results indicate the significant upward enrichment of Zn, Sb, Cr, Nd, and Dy insediments belongs to the Iron Gate Reservoir. The sample 4-Smed is labelled as a hot spot of contamination with Zn, Cr, As, Sb,Nd, and Dy. Also, a trend of increasing concentration in the time period from 1995 to 2016 was found for elements Zn, Cr, and Niin sediment samples in the Iron Gate Reservoir. Chemometric analysis shows the grouping of sample sites into clusters charac-terized by the following properties: (i) increased concentration of all measured elements (samples within the Iron Gate Reservoir);(ii) increased Cu concentration (11-Pek); and (iii) lower concentrations of the measured elements (deep sediments). The datapresented hereby contribute to the monitoring of pollution of the River Danube sediments and give the first view of Ln profile inthe studied sediments.
PB  - Springer Science and Business Media Deutschland GmbH
T2  - Environmental Science and Pollution Research
T1  - Spatial distribution of multielements including lanthanides in sediments of Iron Gate I Reservoir in the Danube River
VL  - 28
SP  - 44877
EP  - 44889
DO  - 10.1007/s11356-021-13752-6
ER  - 

@article{
author = "Culicov, Otilia Ana and Trtić-Petrović, Tatjana and Balvanović, Roman and Petković, Anđelka and Ražić, Slavica",
year = "2021",
abstract = "Recent studies show that lanthanides (Ln) are becoming emerging pollutants due to their wide application in new technologies,but their environmental fate, transport, and possible accumulation are still relatively unknown. This study aims to determinemajor and trace elements including Ln in the Danube River sediment which either belong or close to the Iron Gate Reservoir. TheIron Gate Reservoir is characterized by accumulation of sediments as an effect of building hydropower dam Iron Gate I. Thesurface sediments were collected on the Danube River—1141 to 864 km and three tributaries along this waterway. Two samplesof deep sediments were used for comparison. The results indicate the significant upward enrichment of Zn, Sb, Cr, Nd, and Dy insediments belongs to the Iron Gate Reservoir. The sample 4-Smed is labelled as a hot spot of contamination with Zn, Cr, As, Sb,Nd, and Dy. Also, a trend of increasing concentration in the time period from 1995 to 2016 was found for elements Zn, Cr, and Niin sediment samples in the Iron Gate Reservoir. Chemometric analysis shows the grouping of sample sites into clusters charac-terized by the following properties: (i) increased concentration of all measured elements (samples within the Iron Gate Reservoir);(ii) increased Cu concentration (11-Pek); and (iii) lower concentrations of the measured elements (deep sediments). The datapresented hereby contribute to the monitoring of pollution of the River Danube sediments and give the first view of Ln profile inthe studied sediments.",
publisher = "Springer Science and Business Media Deutschland GmbH",
journal = "Environmental Science and Pollution Research",
title = "Spatial distribution of multielements including lanthanides in sediments of Iron Gate I Reservoir in the Danube River",
volume = "28",
pages = "44877-44889",
doi = "10.1007/s11356-021-13752-6"
}

Culicov, O. A., Trtić-Petrović, T., Balvanović, R., Petković, A.,& Ražić, S.. (2021). Spatial distribution of multielements including lanthanides in sediments of Iron Gate I Reservoir in the Danube River. in Environmental Science and Pollution Research
Springer Science and Business Media Deutschland GmbH., 28, 44877-44889.
https://doi.org/10.1007/s11356-021-13752-6

Culicov OA, Trtić-Petrović T, Balvanović R, Petković A, Ražić S. Spatial distribution of multielements including lanthanides in sediments of Iron Gate I Reservoir in the Danube River. in Environmental Science and Pollution Research. 2021;28:44877-44889.
doi:10.1007/s11356-021-13752-6 .

Culicov, Otilia Ana, Trtić-Petrović, Tatjana, Balvanović, Roman, Petković, Anđelka, Ražić, Slavica, "Spatial distribution of multielements including lanthanides in sediments of Iron Gate I Reservoir in the Danube River" in Environmental Science and Pollution Research, 28 (2021):44877-44889,
https://doi.org/10.1007/s11356-021-13752-6 . .

TY  - CONF
AU  - Dimitrijević, Aleksandra
AU  - Jocić, Ana
AU  - Marić, Slađana
AU  - Zdolšek, Nikola
AU  - Trtić-Petrović, Tatjana
AU  - Vraneš, Milan
AU  - Gadžurić, Slobodan
AU  - Arsenijević, Jelena
AU  - Ražić, Slavica
AU  - Tavares, Ana Paula M.
AU  - Freire, Mara G.
PY  - 2019
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5288
AB  - The chemotherapeutic parthenolide (PTL) has an excellent
potential in the treatment of acute lymphoblastic leukemia and
much attention has been focused to overcome its poor aqueous
solubility, which limits PTL bioavailability. The most promising
approach is using micellar structures of Pluronics (class of triblock
copolymer of poly(ethylene)-poly(propylene)-poly(ethylene)),
as a drug delivery vectors. Pluronic PE6200 (PL6200) is selected
as one of the phase formers of aqueous biphasic system (ABS)
having in mind the amphiphilic nature of Pluronics which enables
good solubilization of hydrophobic molecules, their biocompatibility,
water solubility and complex mesophase behaviour. ABSs
are formed by combination of aqueous solutions of two polymers,
two salts or polymer/salt above certain concentrations with water
as the main constituent of both phases of ABS. In the quest for
more selective, performant and “greener” extraction technique of
PTL from natural matrices, a novel ABS comprised of a hydrophilic
ionic liquid (IL) - cholinium pyruvate (ChPyr) and PL6200
was investigated. In order to design selective Pluronic-mediated
purification process, (1) the ternary phase diagram was determinated
and characterised and (2) the partition of hydrophobic
PTL in this system was evaluated. A solution composed of 20
wt% of ChPyr + 30 wt% of PL6200 + 50 wt% of water with PTL
concentration of 2 mgml-1 led to high PTL extraction efficiency in
PL6200-rich phase (above 82%) with partition coefficient of 4.96.
The partition of PTL is mainly driven by its hydrophobic interaction
with poloxamer. For lower PL6200 concentrations in ABS,
formation of micelle particles was observed, what enabled solubilization
of PTL and its migration to hydrophilic IL-rich phase.
That decreased the PTL extraction efficiency toward PL6200-
rich phase. The obtained results showed that using cholinium-IL
/ Pluronic based ABS is promising alternative to volatile organic solvents that are nowdays used for extraction of PTL. Moreover,
using the Pluronic as constituent of ABS can provide the possibility
to simultaneously deal with low aqueous solubility of PTL by
forming the drug-loaded micelle particles and selective extraction
of active compound from real matrix.
PB  - Turkish Chemical Society
C3  - XX Euroanalysis 2019 Conference, Abstracts and Proceedings
T1  - Controlling of the parthenolide partition using micelle structures of block copolymer in ionic liquid based aqueous biphasic system
SP  - 212
EP  - 214
UR  - https://hdl.handle.net/21.15107/rcub_farfar_5288
ER  - 

@conference{
author = "Dimitrijević, Aleksandra and Jocić, Ana and Marić, Slađana and Zdolšek, Nikola and Trtić-Petrović, Tatjana and Vraneš, Milan and Gadžurić, Slobodan and Arsenijević, Jelena and Ražić, Slavica and Tavares, Ana Paula M. and Freire, Mara G.",
year = "2019",
abstract = "The chemotherapeutic parthenolide (PTL) has an excellent
potential in the treatment of acute lymphoblastic leukemia and
much attention has been focused to overcome its poor aqueous
solubility, which limits PTL bioavailability. The most promising
approach is using micellar structures of Pluronics (class of triblock
copolymer of poly(ethylene)-poly(propylene)-poly(ethylene)),
as a drug delivery vectors. Pluronic PE6200 (PL6200) is selected
as one of the phase formers of aqueous biphasic system (ABS)
having in mind the amphiphilic nature of Pluronics which enables
good solubilization of hydrophobic molecules, their biocompatibility,
water solubility and complex mesophase behaviour. ABSs
are formed by combination of aqueous solutions of two polymers,
two salts or polymer/salt above certain concentrations with water
as the main constituent of both phases of ABS. In the quest for
more selective, performant and “greener” extraction technique of
PTL from natural matrices, a novel ABS comprised of a hydrophilic
ionic liquid (IL) - cholinium pyruvate (ChPyr) and PL6200
was investigated. In order to design selective Pluronic-mediated
purification process, (1) the ternary phase diagram was determinated
and characterised and (2) the partition of hydrophobic
PTL in this system was evaluated. A solution composed of 20
wt% of ChPyr + 30 wt% of PL6200 + 50 wt% of water with PTL
concentration of 2 mgml-1 led to high PTL extraction efficiency in
PL6200-rich phase (above 82%) with partition coefficient of 4.96.
The partition of PTL is mainly driven by its hydrophobic interaction
with poloxamer. For lower PL6200 concentrations in ABS,
formation of micelle particles was observed, what enabled solubilization
of PTL and its migration to hydrophilic IL-rich phase.
That decreased the PTL extraction efficiency toward PL6200-
rich phase. The obtained results showed that using cholinium-IL
/ Pluronic based ABS is promising alternative to volatile organic solvents that are nowdays used for extraction of PTL. Moreover,
using the Pluronic as constituent of ABS can provide the possibility
to simultaneously deal with low aqueous solubility of PTL by
forming the drug-loaded micelle particles and selective extraction
of active compound from real matrix.",
publisher = "Turkish Chemical Society",
journal = "XX Euroanalysis 2019 Conference, Abstracts and Proceedings",
title = "Controlling of the parthenolide partition using micelle structures of block copolymer in ionic liquid based aqueous biphasic system",
pages = "212-214",
url = "https://hdl.handle.net/21.15107/rcub_farfar_5288"
}

Dimitrijević, A., Jocić, A., Marić, S., Zdolšek, N., Trtić-Petrović, T., Vraneš, M., Gadžurić, S., Arsenijević, J., Ražić, S., Tavares, A. P. M.,& Freire, M. G.. (2019). Controlling of the parthenolide partition using micelle structures of block copolymer in ionic liquid based aqueous biphasic system. in XX Euroanalysis 2019 Conference, Abstracts and Proceedings
Turkish Chemical Society., 212-214.
https://hdl.handle.net/21.15107/rcub_farfar_5288

Dimitrijević A, Jocić A, Marić S, Zdolšek N, Trtić-Petrović T, Vraneš M, Gadžurić S, Arsenijević J, Ražić S, Tavares APM, Freire MG. Controlling of the parthenolide partition using micelle structures of block copolymer in ionic liquid based aqueous biphasic system. in XX Euroanalysis 2019 Conference, Abstracts and Proceedings. 2019;:212-214.
https://hdl.handle.net/21.15107/rcub_farfar_5288 .

Dimitrijević, Aleksandra, Jocić, Ana, Marić, Slađana, Zdolšek, Nikola, Trtić-Petrović, Tatjana, Vraneš, Milan, Gadžurić, Slobodan, Arsenijević, Jelena, Ražić, Slavica, Tavares, Ana Paula M., Freire, Mara G., "Controlling of the parthenolide partition using micelle structures of block copolymer in ionic liquid based aqueous biphasic system" in XX Euroanalysis 2019 Conference, Abstracts and Proceedings (2019):212-214,
https://hdl.handle.net/21.15107/rcub_farfar_5288 .