TY  - JOUR
AU  - Topić, Aleksandra
AU  - Prokic, Dragan
AU  - Stankovic, Ivica
PY  - 2011
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/1481
AB  - Alpha-1-antitrypsin deficiency (AATD), which predisposes liver disease in children, is often undiagnosed. Isoelectric focusing in 161 infants with liver dysfunction revealed 14.7% severe and 12.2% moderate AATD. Positive PAS-D and immunohistochemical staining was found in 60% of severe AATD, but in moderate AATD, only immunohistochemistry was positive in 100%. Bilirubinostasis, hepatomegaly, splenomegaly, cholestasis, hepatomegaly associated with cholestasis, acholia, high transaminases, and low birthweight were significantly more frequent in severe than in moderate AATD. Both AATDs showed significant portal inflammation, hepatic fibrosis, and viral infection. Early screening in children with liver dysfunction can contribute to the successful detection of AATD.
PB  - Taylor & Francis Inc, Philadelphia
T2  - Fetal and Pediatric Pathology
T1  - Alpha-1-Antitrypsin Deficiency in Early Childhood
VL  - 30
IS  - 5
SP  - 312
EP  - 319
DO  - 10.3109/15513815.2011.572961
ER  - 

@article{
author = "Topić, Aleksandra and Prokic, Dragan and Stankovic, Ivica",
year = "2011",
abstract = "Alpha-1-antitrypsin deficiency (AATD), which predisposes liver disease in children, is often undiagnosed. Isoelectric focusing in 161 infants with liver dysfunction revealed 14.7% severe and 12.2% moderate AATD. Positive PAS-D and immunohistochemical staining was found in 60% of severe AATD, but in moderate AATD, only immunohistochemistry was positive in 100%. Bilirubinostasis, hepatomegaly, splenomegaly, cholestasis, hepatomegaly associated with cholestasis, acholia, high transaminases, and low birthweight were significantly more frequent in severe than in moderate AATD. Both AATDs showed significant portal inflammation, hepatic fibrosis, and viral infection. Early screening in children with liver dysfunction can contribute to the successful detection of AATD.",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Fetal and Pediatric Pathology",
title = "Alpha-1-Antitrypsin Deficiency in Early Childhood",
volume = "30",
number = "5",
pages = "312-319",
doi = "10.3109/15513815.2011.572961"
}

Topić, A., Prokic, D.,& Stankovic, I.. (2011). Alpha-1-Antitrypsin Deficiency in Early Childhood. in Fetal and Pediatric Pathology
Taylor & Francis Inc, Philadelphia., 30(5), 312-319.
https://doi.org/10.3109/15513815.2011.572961

Topić A, Prokic D, Stankovic I. Alpha-1-Antitrypsin Deficiency in Early Childhood. in Fetal and Pediatric Pathology. 2011;30(5):312-319.
doi:10.3109/15513815.2011.572961 .

Topić, Aleksandra, Prokic, Dragan, Stankovic, Ivica, "Alpha-1-Antitrypsin Deficiency in Early Childhood" in Fetal and Pediatric Pathology, 30, no. 5 (2011):312-319,
https://doi.org/10.3109/15513815.2011.572961 . .