TY  - JOUR
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Baralić, Katarina
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/5033
AB  - The purpose of this study was to examine the impact of low doses of lead (Pb) on levels of thyroid hormones (T3, T4, FT3, and FT4) and thyroid-related antibodies (anti-Tg and anti-TPO) in the rat model, as well as genes that are related to Pb and thyroid function, relationships between genes, biological processes, molecular processes, and pathways using an in silico approach. Male rats were randomized into seven groups (n = 42), one control group and six groups that received a range of Pb doses: 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg body weight (b.w.). Dose-response modelling was performed by PROAST software using model averaging method. The Comparative Toxicogenomics Database, GeneMANIA server, and ToppGene Suite portal were used as the main bioinformatic tools in this analysis. The results of our study have shown that low Pb doses induced elevation of thyroid hormones (T4, FT4, and TSH) in rats after subacute exposure, while had no impact on T3, FT3, anti-TPO, and anti-Tg, indicating hyperthyroidism. Dose-dependent effects were increases in T4 and FT4, with the lowest benchmark dose derived for FT4 levels. In silico toxicogenomic data analysis showed that the main molecular pathways/process related to Pb-induced hyperthyroidism are connected with 14 genes involved in antioxidant defense and Se-dependent processes. The results presented here may be useful in further investigation of the health impacts of low-level Pb exposure on thyroid function and endocrine disruption effects.
PB  - Elsevier
T2  - Environmental Research
T1  - In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function
VL  - 237
DO  - 10.1016/j.envres.2023.117035
ER  - 

@article{
author = "Vukelić, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Baralić, Katarina and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "The purpose of this study was to examine the impact of low doses of lead (Pb) on levels of thyroid hormones (T3, T4, FT3, and FT4) and thyroid-related antibodies (anti-Tg and anti-TPO) in the rat model, as well as genes that are related to Pb and thyroid function, relationships between genes, biological processes, molecular processes, and pathways using an in silico approach. Male rats were randomized into seven groups (n = 42), one control group and six groups that received a range of Pb doses: 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg body weight (b.w.). Dose-response modelling was performed by PROAST software using model averaging method. The Comparative Toxicogenomics Database, GeneMANIA server, and ToppGene Suite portal were used as the main bioinformatic tools in this analysis. The results of our study have shown that low Pb doses induced elevation of thyroid hormones (T4, FT4, and TSH) in rats after subacute exposure, while had no impact on T3, FT3, anti-TPO, and anti-Tg, indicating hyperthyroidism. Dose-dependent effects were increases in T4 and FT4, with the lowest benchmark dose derived for FT4 levels. In silico toxicogenomic data analysis showed that the main molecular pathways/process related to Pb-induced hyperthyroidism are connected with 14 genes involved in antioxidant defense and Se-dependent processes. The results presented here may be useful in further investigation of the health impacts of low-level Pb exposure on thyroid function and endocrine disruption effects.",
publisher = "Elsevier",
journal = "Environmental Research",
title = "In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function",
volume = "237",
doi = "10.1016/j.envres.2023.117035"
}

Vukelić, D., Buha-Đorđević, A., Anđelković, M., Baralić, K., Ćurčić, M., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2023). In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function. in Environmental Research
Elsevier., 237.
https://doi.org/10.1016/j.envres.2023.117035

Vukelić D, Buha-Đorđević A, Anđelković M, Baralić K, Ćurčić M, Đukić-Ćosić D, Antonijević B, Bulat Z. In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function. in Environmental Research. 2023;237.
doi:10.1016/j.envres.2023.117035 .

Vukelić, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Baralić, Katarina, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "In vivo and in silico approach in revealing the influence of lead (Pb) on thyroid gland function" in Environmental Research, 237 (2023),
https://doi.org/10.1016/j.envres.2023.117035 . .

TY  - JOUR
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Baralić, Katarina
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Boričić, Novica
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4385
AB  - The objectives of the study were to simulate low-level Pb exposure scenario in an animal model and to examine reproductive adverse effects. Based on obtained data, we have performed Benchmark dose (BMD)-response modelling. Male Wistar rats were randomized in seven groups (n = 6): one control and six treated with: 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg body weight, daily for 28 days by oral gavage. The rats were sacrificed and the blood and testes were used for further analysis of testosterone levels in serum, testicular essential metal levels and histological analysis. The Pb treatment led to a dose-dependent decrease of serum testosterone levels with a negative trend (BMDI 0.17–6.13 mg Pb/kg). Increase of Zn (dose-dependent, BMDI 0.004–19.7 mg Pb/kg) and Cu and a decrease of Mn testicular levels were also detected with unscathed histology of the testes. The presented results might be used in further evaluation of the point of departure in human health risk assessment for Pb.
PB  - Elsevier Ireland Ltd
T2  - Toxicology Letters
T1  - Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats
VL  - 375
SP  - 69
EP  - 76
DO  - 10.1016/j.toxlet.2023.01.001
ER  - 

@article{
author = "Vukelić, Dragana and Buha-Đorđević, Aleksandra and Anđelković, Milena and Repić, Aleksandra and Baralić, Katarina and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Boričić, Novica and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "The objectives of the study were to simulate low-level Pb exposure scenario in an animal model and to examine reproductive adverse effects. Based on obtained data, we have performed Benchmark dose (BMD)-response modelling. Male Wistar rats were randomized in seven groups (n = 6): one control and six treated with: 0.1, 0.5, 1, 3, 7, and 15 mg Pb/kg body weight, daily for 28 days by oral gavage. The rats were sacrificed and the blood and testes were used for further analysis of testosterone levels in serum, testicular essential metal levels and histological analysis. The Pb treatment led to a dose-dependent decrease of serum testosterone levels with a negative trend (BMDI 0.17–6.13 mg Pb/kg). Increase of Zn (dose-dependent, BMDI 0.004–19.7 mg Pb/kg) and Cu and a decrease of Mn testicular levels were also detected with unscathed histology of the testes. The presented results might be used in further evaluation of the point of departure in human health risk assessment for Pb.",
publisher = "Elsevier Ireland Ltd",
journal = "Toxicology Letters",
title = "Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats",
volume = "375",
pages = "69-76",
doi = "10.1016/j.toxlet.2023.01.001"
}

Vukelić, D., Buha-Đorđević, A., Anđelković, M., Repić, A., Baralić, K., Ćurčić, M., Đukić-Ćosić, D., Boričić, N., Antonijević, B.,& Bulat, Z.. (2023). Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats. in Toxicology Letters
Elsevier Ireland Ltd., 375, 69-76.
https://doi.org/10.1016/j.toxlet.2023.01.001

Vukelić D, Buha-Đorđević A, Anđelković M, Repić A, Baralić K, Ćurčić M, Đukić-Ćosić D, Boričić N, Antonijević B, Bulat Z. Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats. in Toxicology Letters. 2023;375:69-76.
doi:10.1016/j.toxlet.2023.01.001 .

Vukelić, Dragana, Buha-Đorđević, Aleksandra, Anđelković, Milena, Repić, Aleksandra, Baralić, Katarina, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Boričić, Novica, Antonijević, Biljana, Bulat, Zorica, "Derivation of benchmark doses for male reproductive toxicity in a subacute low-level Pb exposure model in rats" in Toxicology Letters, 375 (2023):69-76,
https://doi.org/10.1016/j.toxlet.2023.01.001 . .

TY  - JOUR
AU  - Gladović, Ana
AU  - Petrović, Bojana
AU  - Vukelić, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Šoštarić, Andrej
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4582
AB  - With global urbanization and industrialization, air pollution has become an inevitable problem. Among air pollutants, toxic metals bound to particulate matter (PM) have a high hazardous potential, contributing to the development of several diseases, including various types of cancer. Due to PM pollution, Serbia is considered to be among the most polluted countries in Europe. Therefore, the objective of the study was to assess and characterize the non-carcinogenic and carcinogenic risks of children’s and adults’ exposure to metal(oid)s (Pb, Cd, Ni, and As) bound to PM10 in five of the most polluted areas in the Republic of Serbia (Subotica, Smederevo, Bor, Valjevo, and Kraljevo). Non-carcinogenic (HQ and HI) and carcinogenic risk (CR) were calculated using USEPA methodology. Our results show that PM10 concentrations exceeded the annual limit of 40 μg/m3 at four out of five monitoring sites (ranging from 44.33 to 63.25 μg/m3). Results obtained from Bor monitoring station show that safe limits were exceeded for both children and adults, indicating an unacceptable risk (> 1) obtained for inhalation exposure to the As (HQ = 6.14) and Cd (HQ = 1.17), while total HI was 7.43, which characterized the risk as unacceptable. For the same station, the CR value was 1.44E−04 (> 1 × 10−4). In other sites, the risks were acceptable. The characterized risk from exposure to the toxic elements via PM10 in critical locations in Serbia contributes to improving air quality by requiring regulatory organs to take new actions and adopt new measures to reduce air pollution.
PB  - Springer Nature
T2  - Environmental Science and Pollution Research
T1  - Carcinogenic and human health risk assessment of children’s and adults’ exposure to toxic metal(oid)s from air PM10 in critical sites of the Republic of Serbia
VL  - 30
IS  - 22
SP  - 61753
EP  - 61765
DO  - 10.1007/s11356-023-26375-w
ER  - 

@article{
author = "Gladović, Ana and Petrović, Bojana and Vukelić, Dragana and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Šoštarić, Andrej and Antonijević, Biljana and Bulat, Zorica",
year = "2023",
abstract = "With global urbanization and industrialization, air pollution has become an inevitable problem. Among air pollutants, toxic metals bound to particulate matter (PM) have a high hazardous potential, contributing to the development of several diseases, including various types of cancer. Due to PM pollution, Serbia is considered to be among the most polluted countries in Europe. Therefore, the objective of the study was to assess and characterize the non-carcinogenic and carcinogenic risks of children’s and adults’ exposure to metal(oid)s (Pb, Cd, Ni, and As) bound to PM10 in five of the most polluted areas in the Republic of Serbia (Subotica, Smederevo, Bor, Valjevo, and Kraljevo). Non-carcinogenic (HQ and HI) and carcinogenic risk (CR) were calculated using USEPA methodology. Our results show that PM10 concentrations exceeded the annual limit of 40 μg/m3 at four out of five monitoring sites (ranging from 44.33 to 63.25 μg/m3). Results obtained from Bor monitoring station show that safe limits were exceeded for both children and adults, indicating an unacceptable risk (> 1) obtained for inhalation exposure to the As (HQ = 6.14) and Cd (HQ = 1.17), while total HI was 7.43, which characterized the risk as unacceptable. For the same station, the CR value was 1.44E−04 (> 1 × 10−4). In other sites, the risks were acceptable. The characterized risk from exposure to the toxic elements via PM10 in critical locations in Serbia contributes to improving air quality by requiring regulatory organs to take new actions and adopt new measures to reduce air pollution.",
publisher = "Springer Nature",
journal = "Environmental Science and Pollution Research",
title = "Carcinogenic and human health risk assessment of children’s and adults’ exposure to toxic metal(oid)s from air PM10 in critical sites of the Republic of Serbia",
volume = "30",
number = "22",
pages = "61753-61765",
doi = "10.1007/s11356-023-26375-w"
}

Gladović, A., Petrović, B., Vukelić, D., Buha-Đorđević, A., Ćurčić, M., Đukić-Ćosić, D., Šoštarić, A., Antonijević, B.,& Bulat, Z.. (2023). Carcinogenic and human health risk assessment of children’s and adults’ exposure to toxic metal(oid)s from air PM10 in critical sites of the Republic of Serbia. in Environmental Science and Pollution Research
Springer Nature., 30(22), 61753-61765.
https://doi.org/10.1007/s11356-023-26375-w

Gladović A, Petrović B, Vukelić D, Buha-Đorđević A, Ćurčić M, Đukić-Ćosić D, Šoštarić A, Antonijević B, Bulat Z. Carcinogenic and human health risk assessment of children’s and adults’ exposure to toxic metal(oid)s from air PM10 in critical sites of the Republic of Serbia. in Environmental Science and Pollution Research. 2023;30(22):61753-61765.
doi:10.1007/s11356-023-26375-w .

Gladović, Ana, Petrović, Bojana, Vukelić, Dragana, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Šoštarić, Andrej, Antonijević, Biljana, Bulat, Zorica, "Carcinogenic and human health risk assessment of children’s and adults’ exposure to toxic metal(oid)s from air PM10 in critical sites of the Republic of Serbia" in Environmental Science and Pollution Research, 30, no. 22 (2023):61753-61765,
https://doi.org/10.1007/s11356-023-26375-w . .

TY  - JOUR
AU  - Božić, Dragica
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4425
AB  - Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. It becomes bioactive after hydrolytic reaction mediated by myrosinase or human gastrointestinal microbiota. Sulforaphane gained scientific popularity due to its antioxidant and anti-cancer properties. However, its toxicity profile and potential to cause adverse effects remain largely unidentified. Thus, this study aimed to generate SFN-triggered adverse outcome pathway (AOP) by looking at the relationship between SFN-chemical structure and its toxicity, as well as SFN-gene interactions. Quantitative structure-activity relationship (QSAR) analysis identified 2 toxophores (Derek Nexus software) that have the potential to cause chromosomal damage and skin sensitization in mammals or mutagenicity in bacteria. Data extracted from Comparative Toxicogenomics Database (CTD) linked SFN with previously proposed outcomes via gene interactions. The total of 11 and 146 genes connected SFN with chromosomal damage and skin diseases, respectively. However, network analysis (NetworkAnalyst tool) revealed that these genes function in wider networks containing 490 and 1986 nodes, respectively. The over-representation analysis (ExpressAnalyst tool) pointed out crucial biological pathways regulated by SFN-interfering genes. These pathways are uploaded to AOP-helpFinder tool which found the 2321 connections between 19 enriched pathways and SFN which were further considered as key events. Two major, interconnected AOPs were generated: first starting from disruption of biological pathways involved in cell cycle and cell proliferation leading to increased apoptosis, and the second one connecting activated immune system signaling pathways to inflammation and apoptosis. In both cases, chromosomal damage and/or skin diseases such as dermatitis or psoriasis appear as adverse outcomes.
PB  - Elsevier
T2  - Biomedicine and Pharmacotherapy
T1  - Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells
VL  - 160
DO  - 10.1016/j.biopha.2023.114316
ER  - 

@article{
author = "Božić, Dragica and Živančević, Katarina and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Sulforaphane (SFN) is a naturally occurring molecule present in plants from Brassica family. It becomes bioactive after hydrolytic reaction mediated by myrosinase or human gastrointestinal microbiota. Sulforaphane gained scientific popularity due to its antioxidant and anti-cancer properties. However, its toxicity profile and potential to cause adverse effects remain largely unidentified. Thus, this study aimed to generate SFN-triggered adverse outcome pathway (AOP) by looking at the relationship between SFN-chemical structure and its toxicity, as well as SFN-gene interactions. Quantitative structure-activity relationship (QSAR) analysis identified 2 toxophores (Derek Nexus software) that have the potential to cause chromosomal damage and skin sensitization in mammals or mutagenicity in bacteria. Data extracted from Comparative Toxicogenomics Database (CTD) linked SFN with previously proposed outcomes via gene interactions. The total of 11 and 146 genes connected SFN with chromosomal damage and skin diseases, respectively. However, network analysis (NetworkAnalyst tool) revealed that these genes function in wider networks containing 490 and 1986 nodes, respectively. The over-representation analysis (ExpressAnalyst tool) pointed out crucial biological pathways regulated by SFN-interfering genes. These pathways are uploaded to AOP-helpFinder tool which found the 2321 connections between 19 enriched pathways and SFN which were further considered as key events. Two major, interconnected AOPs were generated: first starting from disruption of biological pathways involved in cell cycle and cell proliferation leading to increased apoptosis, and the second one connecting activated immune system signaling pathways to inflammation and apoptosis. In both cases, chromosomal damage and/or skin diseases such as dermatitis or psoriasis appear as adverse outcomes.",
publisher = "Elsevier",
journal = "Biomedicine and Pharmacotherapy",
title = "Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells",
volume = "160",
doi = "10.1016/j.biopha.2023.114316"
}

Božić, D., Živančević, K., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells. in Biomedicine and Pharmacotherapy
Elsevier., 160.
https://doi.org/10.1016/j.biopha.2023.114316

Božić D, Živančević K, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells. in Biomedicine and Pharmacotherapy. 2023;160.
doi:10.1016/j.biopha.2023.114316 .

Božić, Dragica, Živančević, Katarina, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Conducting bioinformatics analysis to predict sulforaphane-triggered adverse outcome pathways in healthy human cells" in Biomedicine and Pharmacotherapy, 160 (2023),
https://doi.org/10.1016/j.biopha.2023.114316 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Marić, Đurđica
AU  - Božić, Dragica
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4651
AB  - Toxic metals (cadmium (Cd), lead (Pb), mercury (Hg) and arsenic (As)) and plastificators (bis (2 – ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP)) and bisphenol A (BPA)) have been suggested to aid in colorectal carcinoma (CRC) advancement. Sulforaphane (SFN), isothiocyanate from cruciferous vegetables, diminishes chemical carcinogenesis susceptibility, but has been shown to act as a friend or a foe depending on various factors. By conducting the mechanistic toxicogenomic data mining approach, this research aimed to determine if SFN can alleviate toxic-metal and/or phthalate/BPA mixture-induced CRC at the gene level. Comparative Toxicogenomics Database, ToppGene Suite portal, Cytoscape software, InteractiVenn and Gene Expression Omnibus (GEO) database (GEO2R tool) was used. Among the mutual genes for all the investigated substances, SFN had a protective impact only through PTGS2. Other proposed protective SFN-targets included ABCA1, ALDH2, BMP2, DPYD, MYC, SLCO2A1, and SOD2, only in the case of phthalates/BPA exposure. The only additional gene relevant for SFN protection against the toxic metal mixture-induced CRC was ABCB1. Additionally, the majority of the top 15 molecular pathways extracted for SFN impact on phthalate and BPA mixture-linked CRC development were directly linked with cancer development, which was not the case with the toxic metal mixture. The current research has indicated that SFN is a more effective chemoprotective agent against CRC induced by phthalates/BPA mixture than by toxic-metal mixture. It has also presented the value of computational methods as a simple tool for directing further research, selecting appropriate biomarkers and exploring the mechanisms of toxicity.
PB  - Academic Press Inc.
T2  - Environmental Research
T1  - Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study
VL  - 227
DO  - 10.1016/j.envres.2023.115818
ER  - 

@article{
author = "Baralić, Katarina and Živančević, Katarina and Marić, Đurđica and Božić, Dragica and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Toxic metals (cadmium (Cd), lead (Pb), mercury (Hg) and arsenic (As)) and plastificators (bis (2 – ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP)) and bisphenol A (BPA)) have been suggested to aid in colorectal carcinoma (CRC) advancement. Sulforaphane (SFN), isothiocyanate from cruciferous vegetables, diminishes chemical carcinogenesis susceptibility, but has been shown to act as a friend or a foe depending on various factors. By conducting the mechanistic toxicogenomic data mining approach, this research aimed to determine if SFN can alleviate toxic-metal and/or phthalate/BPA mixture-induced CRC at the gene level. Comparative Toxicogenomics Database, ToppGene Suite portal, Cytoscape software, InteractiVenn and Gene Expression Omnibus (GEO) database (GEO2R tool) was used. Among the mutual genes for all the investigated substances, SFN had a protective impact only through PTGS2. Other proposed protective SFN-targets included ABCA1, ALDH2, BMP2, DPYD, MYC, SLCO2A1, and SOD2, only in the case of phthalates/BPA exposure. The only additional gene relevant for SFN protection against the toxic metal mixture-induced CRC was ABCB1. Additionally, the majority of the top 15 molecular pathways extracted for SFN impact on phthalate and BPA mixture-linked CRC development were directly linked with cancer development, which was not the case with the toxic metal mixture. The current research has indicated that SFN is a more effective chemoprotective agent against CRC induced by phthalates/BPA mixture than by toxic-metal mixture. It has also presented the value of computational methods as a simple tool for directing further research, selecting appropriate biomarkers and exploring the mechanisms of toxicity.",
publisher = "Academic Press Inc.",
journal = "Environmental Research",
title = "Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study",
volume = "227",
doi = "10.1016/j.envres.2023.115818"
}

Baralić, K., Živančević, K., Marić, Đ., Božić, D., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study. in Environmental Research
Academic Press Inc.., 227.
https://doi.org/10.1016/j.envres.2023.115818

Baralić K, Živančević K, Marić Đ, Božić D, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study. in Environmental Research. 2023;227.
doi:10.1016/j.envres.2023.115818 .

Baralić, Katarina, Živančević, Katarina, Marić, Đurđica, Božić, Dragica, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Testing sulforaphane as a strategy against toxic chemicals of public health concern by toxicogenomic data analysis: Friend or foe at the gene level – Colorectal carcinoma case study" in Environmental Research, 227 (2023),
https://doi.org/10.1016/j.envres.2023.115818 . .

TY  - JOUR
AU  - Radović, Biljana
AU  - Stojilković, Nikola
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Vukelić-Javorac, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4613
AB  - The current study aimed to assess the connection between the mixture of lead (Pb), cadmium (Cd), arsenic (As), methylmercury (MeHg) and decabrominated diphenyl ether (decaBDE) and thyroid function, by using in silico toxicogenomic data-mining approach. To obtain the linkage between investigated toxic mixture and thyroid diseases (TDs), the Comparative Toxicogenomics Database (CTD) was used, while gene ontology (GO) enrichment analysis was performed by ToppGeneSuite portal. The analysis has shown 10 genes connected to all chemicals present in the mixture and TDs (CAT, GSR, IFNG, IL1B, IL4, IL6, MAPK1, SOD2, TGFB1, TNF), most of which were in co-expression (45.68%), or belonged to the same pathway (30.47%). Top 5 biological processes and molecular functions affected by the investigated mixture emphasized the role of two common mechanisms – oxidative stress and inflammation. Cytokines and inflammatory response was listed as the main molecular pathway that may be triggered by simultaneous exposure to toxic metal(oid)s and decaBDE and connected to TDs. The direct relations between Pb/decaBDE and redox status impairment in thyroid tissue was confirmed by our chemical-phenotype interaction analysis, while the strongest linkage between Pb, As and decaBDE and thyroid disorders was found. The obtained results provide better understanding of molecular mechanisms involved in the thyrotoxicity of the investigated mixture, and can be used to direct further research.
PB  - Elsevier Ireland Ltd
T2  - Toxicology
T1  - In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether
VL  - 489
DO  - 10.1016/j.tox.2023.153496
ER  - 

@article{
author = "Radović, Biljana and Stojilković, Nikola and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Vukelić-Javorac, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana",
year = "2023",
abstract = "The current study aimed to assess the connection between the mixture of lead (Pb), cadmium (Cd), arsenic (As), methylmercury (MeHg) and decabrominated diphenyl ether (decaBDE) and thyroid function, by using in silico toxicogenomic data-mining approach. To obtain the linkage between investigated toxic mixture and thyroid diseases (TDs), the Comparative Toxicogenomics Database (CTD) was used, while gene ontology (GO) enrichment analysis was performed by ToppGeneSuite portal. The analysis has shown 10 genes connected to all chemicals present in the mixture and TDs (CAT, GSR, IFNG, IL1B, IL4, IL6, MAPK1, SOD2, TGFB1, TNF), most of which were in co-expression (45.68%), or belonged to the same pathway (30.47%). Top 5 biological processes and molecular functions affected by the investigated mixture emphasized the role of two common mechanisms – oxidative stress and inflammation. Cytokines and inflammatory response was listed as the main molecular pathway that may be triggered by simultaneous exposure to toxic metal(oid)s and decaBDE and connected to TDs. The direct relations between Pb/decaBDE and redox status impairment in thyroid tissue was confirmed by our chemical-phenotype interaction analysis, while the strongest linkage between Pb, As and decaBDE and thyroid disorders was found. The obtained results provide better understanding of molecular mechanisms involved in the thyrotoxicity of the investigated mixture, and can be used to direct further research.",
publisher = "Elsevier Ireland Ltd",
journal = "Toxicology",
title = "In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether",
volume = "489",
doi = "10.1016/j.tox.2023.153496"
}

Radović, B., Stojilković, N., Ćurčić, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Vukelić-Javorac, D., Baralić, K., Đukić-Ćosić, D., Bulat, Z.,& Antonijević, B.. (2023). In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether. in Toxicology
Elsevier Ireland Ltd., 489.
https://doi.org/10.1016/j.tox.2023.153496

Radović B, Stojilković N, Ćurčić M, Antonijević-Miljaković E, Buha-Đorđević A, Vukelić-Javorac D, Baralić K, Đukić-Ćosić D, Bulat Z, Antonijević B. In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether. in Toxicology. 2023;489.
doi:10.1016/j.tox.2023.153496 .

Radović, Biljana, Stojilković, Nikola, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Vukelić-Javorac, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, "In silico assessment of mixture toxicity mechanisms involved in the pathogenesis of thyroid diseases: The combination of toxic metal(oid)s and decabrominated diphenyl ether" in Toxicology, 489 (2023),
https://doi.org/10.1016/j.tox.2023.153496 . .

TY  - JOUR
AU  - Baralić, Katarina
AU  - Pavić, Aleksandar
AU  - Javorac, Dragana
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Radaković, Nataša
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4334
AB  - Connections between the mixture containing bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) and liver injury were explored through in silico investigation and 2 in vivo models. Comparative Toxicogenomics Database (CTD), ShinyGO, ToppCluster and Cytoscape were used for bioinformatic analysis. In vivo subacute study was performed on rats - five groups (n = 6): (1) Control: corn oil, (2) DEHP: 50 mg/kg b.w./day, (3) DBP: 50 mg/kg b.w./day, (4) BPA: 25 mg/kg b.w./day, (5) MIX: DEHP + DBP + BPA. Zebrafish embryos were exposed to the investigated substances in different doses, singularly and combined (binary and ternary mixtures). Liver injury was linked to 75 DEHP, DBP, and BPA genes, mostly connected to inflammation/oxidative stress. In rats, significant alterations in redox status/bioelements and pathohistology were most notable or exclusively present in MIX (probable additive effects). BPA decreased liver area (LA) index in dose-dependent manner. DEHP (< 2 µg/mL) and DBP (≤ 5 µg/mL) reduced LA values, while their higher doses increased LA index. The effect of DBP in binary mixtures led to a lethal outcome at the two highest concentrations, while the hepatotoxicity of DEHP/DBP/BPA mixture was dictated by BPA (confirmed by the benchmark dose analysis).
PB  - Elsevier B.V.
T2  - Journal of Hazardous Materials
T1  - Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A
VL  - 445
DO  - 10.1016/j.jhazmat.2022.130404
ER  - 

@article{
author = "Baralić, Katarina and Pavić, Aleksandar and Javorac, Dragana and Živančević, Katarina and Božić, Dragica and Radaković, Nataša and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2023",
abstract = "Connections between the mixture containing bis(2- ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP) and bisphenol A (BPA) and liver injury were explored through in silico investigation and 2 in vivo models. Comparative Toxicogenomics Database (CTD), ShinyGO, ToppCluster and Cytoscape were used for bioinformatic analysis. In vivo subacute study was performed on rats - five groups (n = 6): (1) Control: corn oil, (2) DEHP: 50 mg/kg b.w./day, (3) DBP: 50 mg/kg b.w./day, (4) BPA: 25 mg/kg b.w./day, (5) MIX: DEHP + DBP + BPA. Zebrafish embryos were exposed to the investigated substances in different doses, singularly and combined (binary and ternary mixtures). Liver injury was linked to 75 DEHP, DBP, and BPA genes, mostly connected to inflammation/oxidative stress. In rats, significant alterations in redox status/bioelements and pathohistology were most notable or exclusively present in MIX (probable additive effects). BPA decreased liver area (LA) index in dose-dependent manner. DEHP (< 2 µg/mL) and DBP (≤ 5 µg/mL) reduced LA values, while their higher doses increased LA index. The effect of DBP in binary mixtures led to a lethal outcome at the two highest concentrations, while the hepatotoxicity of DEHP/DBP/BPA mixture was dictated by BPA (confirmed by the benchmark dose analysis).",
publisher = "Elsevier B.V.",
journal = "Journal of Hazardous Materials",
title = "Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A",
volume = "445",
doi = "10.1016/j.jhazmat.2022.130404"
}

Baralić, K., Pavić, A., Javorac, D., Živančević, K., Božić, D., Radaković, N., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2023). Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A. in Journal of Hazardous Materials
Elsevier B.V.., 445.
https://doi.org/10.1016/j.jhazmat.2022.130404

Baralić K, Pavić A, Javorac D, Živančević K, Božić D, Radaković N, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A. in Journal of Hazardous Materials. 2023;445.
doi:10.1016/j.jhazmat.2022.130404 .

Baralić, Katarina, Pavić, Aleksandar, Javorac, Dragana, Živančević, Katarina, Božić, Dragica, Radaković, Nataša, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Comprehensive investigation of hepatotoxicity of the mixture containing phthalates and bisphenol A" in Journal of Hazardous Materials, 445 (2023),
https://doi.org/10.1016/j.jhazmat.2022.130404 . .

TY  - JOUR
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, Vesna
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
AU  - Janković, Saša
AU  - Vučinić, Slavica
AU  - Hayes, Wallace
AU  - Antonijević, Biljana
PY  - 2023
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4326
AB  - The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per group) were given by oral gavage Aroclor 1254 dissolved in corn oil at doses of 0.0, 0.5, 1, 2, 4, 8, or 16 mg/kg b.w./day for 28 days. The PCB nephrotoxicity was manifested by a dose-dependent changes in serum urea levels. The study has also revealed PCB-induced oxidative stress induction in kidneys. The observed nephrotoxic effects can be partly explained by oxidative damage of lipids and proteins in the kidneys due to observed reduced CuZnSOD activity and disturbances in antioxidant protection. Аll the renal oxidative stress parameters showed dependence on PCB oral doses as well as internal, measure kidney PCB levels. Calculated BMDL values were lower than estimated no observed adverse effect levels (NOAEL) based on the study, suggesting the importance of BMD approach use in future risk assessment.
PB  - Elsevier Inc
T2  - Environmental Research
T1  - New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model
VL  - 217
DO  - 10.1016/j.envres.2022.114829
ER  - 

@article{
author = "Buha-Đorđević, Aleksandra and Milovanović, Vesna and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Bulat, Zorica and Đukić-Ćosić, Danijela and Janković, Saša and Vučinić, Slavica and Hayes, Wallace and Antonijević, Biljana",
year = "2023",
abstract = "The present study investigated the effects of PCBs on the rat kidneys with attention given to the determination critical effect dose (CED) using the Benchmark dose (BMD) approach. Male albino Wistar rats (7 animals per group) were given by oral gavage Aroclor 1254 dissolved in corn oil at doses of 0.0, 0.5, 1, 2, 4, 8, or 16 mg/kg b.w./day for 28 days. The PCB nephrotoxicity was manifested by a dose-dependent changes in serum urea levels. The study has also revealed PCB-induced oxidative stress induction in kidneys. The observed nephrotoxic effects can be partly explained by oxidative damage of lipids and proteins in the kidneys due to observed reduced CuZnSOD activity and disturbances in antioxidant protection. Аll the renal oxidative stress parameters showed dependence on PCB oral doses as well as internal, measure kidney PCB levels. Calculated BMDL values were lower than estimated no observed adverse effect levels (NOAEL) based on the study, suggesting the importance of BMD approach use in future risk assessment.",
publisher = "Elsevier Inc",
journal = "Environmental Research",
title = "New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model",
volume = "217",
doi = "10.1016/j.envres.2022.114829"
}

Buha-Đorđević, A., Milovanović, V., Ćurčić, M., Antonijević-Miljaković, E., Bulat, Z., Đukić-Ćosić, D., Janković, S., Vučinić, S., Hayes, W.,& Antonijević, B.. (2023). New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model. in Environmental Research
Elsevier Inc., 217.
https://doi.org/10.1016/j.envres.2022.114829

Buha-Đorđević A, Milovanović V, Ćurčić M, Antonijević-Miljaković E, Bulat Z, Đukić-Ćosić D, Janković S, Vučinić S, Hayes W, Antonijević B. New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model. in Environmental Research. 2023;217.
doi:10.1016/j.envres.2022.114829 .

Buha-Đorđević, Aleksandra, Milovanović, Vesna, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Bulat, Zorica, Đukić-Ćosić, Danijela, Janković, Saša, Vučinić, Slavica, Hayes, Wallace, Antonijević, Biljana, "New insight into the perplexing toxic features of PCBs: A study of nephrotoxicity in an animal model" in Environmental Research, 217 (2023),
https://doi.org/10.1016/j.envres.2022.114829 . .

TY  - CONF
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Anđelković, Milena
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Mandić-Rajčević, Stefan
AU  - Aćimović, Miodrag
AU  - Buha-Đorđević, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4609
AB  - Exposure to lead (Pb) and cadmium (Cd) poses risk to human health. It is known that
these metals have toxic impact on male reproductive system, leading to physiological
disorders and infertility. Limited data indicates the carcinogenic potential of Pb, while Cd has
been recognized as carcinogen. Benchmark dose-effect modeling can be applied to data from
human, animal and ecotoxicological studies with the aim to obtain Benchmark dose (BMD),
starting point in human health risk assessment. The aim of this study was to use Benchmark
modeling to determine the dose-effect relationship between Pb and Cd levels in tissues of
testicular and prostate cancer patients and serum testosterone levels. The study was
conducted at the Clinical Center of Serbia, and included 104 patients with prostate and
testicular cancer. Cd and Pb levels (ng/g) were measured by atomic absorption
spectrophotometry in isolated healthy surrounding and carcinoma-affected tissues.
Testosterone levels (ng/mL) were measured using the chemiluminescence immunoassay
(CLIA) method. Dose-effect modeling was performed using PROAST70.1 software with
continuous data. The dose dependence was obtained between Cd levels in tumor tissue and
testosterone levels (BMD: 0.0024 ng Cd/g, prostate cancer and 0.0038 ng Cd/g, testicular
cancer). Dose dependence was obtained between Cd levels in healthy surrounding tissue and
testosterone levels (BMD: 0.0092 ng Cd/g). No dose dependence was obtained when
modeling Pb levels as a dose. The data from this study indicate a potential link between Cd
and testosterone levels, i.e. potential association of Cd exposure with male reproductive
health.
AB  - Izloženost olovu (Pb) i kadmijumu (Cd) predstavlja rizik po zdravlje ljudi. Poznato je da ovi
metali deluju toksično na muški reproduktivni sistem dovodeći do poremećaja fizioloških
funkcija i neplodnosti. Ograničen broj studija ukazuje na kancerogeni potencijal Pb, dok je Cd
poznatihumani karcinogen. Benchmark modelovanje odnosa doza-efekat se teoretski može
primeniti na podacima iz humanih, animalnih i ekotoksikoloških studija, sa ciljem dobijanja
Benchmark doze (BMD) kao polazne tačke u proceni rizika po zdravlje ljudi. Cilj ovog rada
bio je da se Benchmark modelovanjem utvrdi odnos doza-efekat između nivoa Pb i Cd u
tkivima karcinoma testisa i prostate pacijenata i nivoa testosterona u serumu. Studija je
sprovedena na Kliničkom centru Srbije i uključila je 104 pacijenta sa karcinomom prostate i
testisa. Nivoi Cd i Pb (ng/g) su izmereni metodom atomske apsorpcione spektrofotometrije u
izolovanim zdravim okolonim i karcinomom zahvaćenim tkivima. Nivoi testosterona
(ng/mL) su mereni pomoću metode direktnog kompetitivnog hemiluminiscentnog
imunoeseja (CLIA). Modelovanje odnosa doza-efekat je vršeno pomoću PROAST 70.1
softvera (RIVM, Holandija) uz upotrebu kontinuiranih podataka. Dozna zavisnost je dobijena
između nivoa Cd u tumorskom tkivu i nivoa testosterona gde je BMD vrednost iznosila
0,0024 ng Cd/g (karcinom prostate) i 0,0038 ng Cd/g (karcinom testisa). Dozna zavisnost je
dobijena i za modelovanje odnosa nivoa Cd u zdravom tkivu i testosterona, sa BMD
vrednošću 0,0092 ng Cd/g. Pri modelovanju nivoa Pb nije dobijena dozna zavisnost. Podaci
ove studije ukazuju na potencijalnu vezu između nivoa Cd u tkivu i nivoa testosterona,
ukazujući na efekte izloženosti ovom metalu na muško reproduktivno zdravlje.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Modeling of dose-response relationships between Pb and Cd levels in testicular and prostate cancer tissues and testosterone levels
T1  - Modelovanje odnosa doza‐odgovor između nivoa Pb i Cd u tkivima karcinoma testisa i prostate i nivoa testosterona
VL  - 72
IS  - 4 suplement
SP  - S569
EP  - S570
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4609
ER  - 

@conference{
author = "Javorac, Dragana and Baralić, Katarina and Marić, Đurđica and Antonijević-Miljaković, Evica and Anđelković, Milena and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Bulat, Zorica and Antonijević, Biljana and Mandić-Rajčević, Stefan and Aćimović, Miodrag and Buha-Đorđević, Aleksandra",
year = "2022",
abstract = "Exposure to lead (Pb) and cadmium (Cd) poses risk to human health. It is known that
these metals have toxic impact on male reproductive system, leading to physiological
disorders and infertility. Limited data indicates the carcinogenic potential of Pb, while Cd has
been recognized as carcinogen. Benchmark dose-effect modeling can be applied to data from
human, animal and ecotoxicological studies with the aim to obtain Benchmark dose (BMD),
starting point in human health risk assessment. The aim of this study was to use Benchmark
modeling to determine the dose-effect relationship between Pb and Cd levels in tissues of
testicular and prostate cancer patients and serum testosterone levels. The study was
conducted at the Clinical Center of Serbia, and included 104 patients with prostate and
testicular cancer. Cd and Pb levels (ng/g) were measured by atomic absorption
spectrophotometry in isolated healthy surrounding and carcinoma-affected tissues.
Testosterone levels (ng/mL) were measured using the chemiluminescence immunoassay
(CLIA) method. Dose-effect modeling was performed using PROAST70.1 software with
continuous data. The dose dependence was obtained between Cd levels in tumor tissue and
testosterone levels (BMD: 0.0024 ng Cd/g, prostate cancer and 0.0038 ng Cd/g, testicular
cancer). Dose dependence was obtained between Cd levels in healthy surrounding tissue and
testosterone levels (BMD: 0.0092 ng Cd/g). No dose dependence was obtained when
modeling Pb levels as a dose. The data from this study indicate a potential link between Cd
and testosterone levels, i.e. potential association of Cd exposure with male reproductive
health., Izloženost olovu (Pb) i kadmijumu (Cd) predstavlja rizik po zdravlje ljudi. Poznato je da ovi
metali deluju toksično na muški reproduktivni sistem dovodeći do poremećaja fizioloških
funkcija i neplodnosti. Ograničen broj studija ukazuje na kancerogeni potencijal Pb, dok je Cd
poznatihumani karcinogen. Benchmark modelovanje odnosa doza-efekat se teoretski može
primeniti na podacima iz humanih, animalnih i ekotoksikoloških studija, sa ciljem dobijanja
Benchmark doze (BMD) kao polazne tačke u proceni rizika po zdravlje ljudi. Cilj ovog rada
bio je da se Benchmark modelovanjem utvrdi odnos doza-efekat između nivoa Pb i Cd u
tkivima karcinoma testisa i prostate pacijenata i nivoa testosterona u serumu. Studija je
sprovedena na Kliničkom centru Srbije i uključila je 104 pacijenta sa karcinomom prostate i
testisa. Nivoi Cd i Pb (ng/g) su izmereni metodom atomske apsorpcione spektrofotometrije u
izolovanim zdravim okolonim i karcinomom zahvaćenim tkivima. Nivoi testosterona
(ng/mL) su mereni pomoću metode direktnog kompetitivnog hemiluminiscentnog
imunoeseja (CLIA). Modelovanje odnosa doza-efekat je vršeno pomoću PROAST 70.1
softvera (RIVM, Holandija) uz upotrebu kontinuiranih podataka. Dozna zavisnost je dobijena
između nivoa Cd u tumorskom tkivu i nivoa testosterona gde je BMD vrednost iznosila
0,0024 ng Cd/g (karcinom prostate) i 0,0038 ng Cd/g (karcinom testisa). Dozna zavisnost je
dobijena i za modelovanje odnosa nivoa Cd u zdravom tkivu i testosterona, sa BMD
vrednošću 0,0092 ng Cd/g. Pri modelovanju nivoa Pb nije dobijena dozna zavisnost. Podaci
ove studije ukazuju na potencijalnu vezu između nivoa Cd u tkivu i nivoa testosterona,
ukazujući na efekte izloženosti ovom metalu na muško reproduktivno zdravlje.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Modeling of dose-response relationships between Pb and Cd levels in testicular and prostate cancer tissues and testosterone levels, Modelovanje odnosa doza‐odgovor između nivoa Pb i Cd u tkivima karcinoma testisa i prostate i nivoa testosterona",
volume = "72",
number = "4 suplement",
pages = "S569-S570",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4609"
}

Javorac, D., Baralić, K., Marić, Đ., Antonijević-Miljaković, E., Anđelković, M., Ćurčić, M., Đukić-Ćosić, D., Bulat, Z., Antonijević, B., Mandić-Rajčević, S., Aćimović, M.,& Buha-Đorđević, A.. (2022). Modeling of dose-response relationships between Pb and Cd levels in testicular and prostate cancer tissues and testosterone levels. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S569-S570.
https://hdl.handle.net/21.15107/rcub_farfar_4609

Javorac D, Baralić K, Marić Đ, Antonijević-Miljaković E, Anđelković M, Ćurčić M, Đukić-Ćosić D, Bulat Z, Antonijević B, Mandić-Rajčević S, Aćimović M, Buha-Đorđević A. Modeling of dose-response relationships between Pb and Cd levels in testicular and prostate cancer tissues and testosterone levels. in Arhiv za farmaciju. 2022;72(4 suplement):S569-S570.
https://hdl.handle.net/21.15107/rcub_farfar_4609 .

Javorac, Dragana, Baralić, Katarina, Marić, Đurđica, Antonijević-Miljaković, Evica, Anđelković, Milena, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Bulat, Zorica, Antonijević, Biljana, Mandić-Rajčević, Stefan, Aćimović, Miodrag, Buha-Đorđević, Aleksandra, "Modeling of dose-response relationships between Pb and Cd levels in testicular and prostate cancer tissues and testosterone levels" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S569-S570,
https://hdl.handle.net/21.15107/rcub_farfar_4609 .

TY  - CONF
AU  - Anđelković, Milena
AU  - Buha-Đorđević, Aleksandra
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Čolaković, Nataša
AU  - Aćimović, Miodrag
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4497
AB  - The endocrine potential of Cd and Pb, an important mechanism of their toxicity, has
been established in certain hormone-dependent cancers (1,2). This study aimed to
determine Cd and Pb levels in blood, tumor and healthy surrounding tissue of patients with
breast, prostate and testis cancer and investigate the correlation of Cd and Pb with sex
hormone levels in the patient's blood. The study involved 55 breast, 41 prostate and 52 testis
cancer patients, while healthy women (41) and men (61) represented control groups.
Electrothermal atomic absorption spectrophotometry was used for Cd and Pb levels
determination. Significantly higher Cd levels, i.e. lower Pb in tumor tissue compared to the
healthy surrounding tissue were found in patients with breast cancer. A positive correlation
was confirmed between Cd levels in the changed tissue and both human gonadotropins, and
a negative correlation with estradiol, as well between Pb in tumor tissue and testosterone
levels. Patients with prostate and testis cancer were characterized by significantly higher
blood Cd levels compared to healthy subjects. Furthermore, significant Cd and Pb tumor
tissue accumulation was shown in prostate and testis cancer patients. A significant positive
correlation was found between blood Cd and estradiol levels in patients with prostate
cancer. The study highlighted higher Cd level as a significant predictor of cancer, and
confirmed impaired sex hormone homeostasis as pivotal mechanism of toxicity underlying
the toxic effects of Cd and Pb in patients with breast, prostate and testis cancer.
AB  - Endokrini potencijal kadmijuma (Cd) i olova (Pb), kao važan mehanizam toksičnosti
oba metala, potvrđen je kod određenih hormon-zavisnih karcinoma (1,2). Ova studija je
imala za cilj da utvrdi koncentracije Cd i Pb u krvi, tumorskom i okolnom zdravom tkivu
pacijenata sa karcinomom dojke, prostate i testisa i ispita korelaciju Cd i Pb sa nivoom polnih
hormona u krvi pacijenata. Obuhvatila je 55 pacijentkinja sa karcinomom dojke, 41 pacijenta
sa karcinomom prostate i 52 pacijenta sa karcinomom testisa, dok su u kontrolnu grupu bile
uključene zdrave žene (41) i zdravi muškarci (61). Koncentracije Cd i Pb su analizirane
elektrotermalnom atomskom apsorpcionom spektrofotometrijom. Značajno više
koncentracije Cd, odnosno niže Pb u tumorskom u odnosu na okolno zdravo tkivo utvrđene
su kod pacijentkinja sa karcinomom dojke. Pozitivna korelacija je potvrđena između
koncentracija Cd u tkivu izmenjene strukture i oba humana gonadotropina, a negativna sa
estradiolom, te između Pb u tumorskom tkivu i testosterona. Pacijente sa karcinomom
prostate i testisa karakterisale su značajno više koncentracije Cd u krvi u odnosu na zdrave
ispitanike, a pokazana je i značajna akumulacija Cd i Pb u tumorskom tkivu prostate i testisa.
Značajna pozitivna korelacija utvrđena je između koncentracije Cd i estradiola u krvi kod
pacijenata sa karcinom prostate. Studija je pokazala da su više koncentracije Cd značajan
prediktor za nastanak karcinoma i potvrdilanarušenu homeostazu polnih hormona kao
važan mehanizam toksičnosti koji se nalazi u osnovi toksičnih efekata Cd i Pb kod obolelih od
karcinoma dojke, prostate i testisa.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?
T1  - Narušena homeostaza polnih hormona kod pacijenata sa karcinom dojke, prostate i testisa: koja je uloga kadmijuma i olova
VL  - 72
IS  - 4 suplement
SP  - S211
EP  - S212
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4497
ER  - 

@conference{
author = "Anđelković, Milena and Buha-Đorđević, Aleksandra and Javorac, Dragana and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević, Biljana and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Čolaković, Nataša and Aćimović, Miodrag and Bulat, Zorica",
year = "2022",
abstract = "The endocrine potential of Cd and Pb, an important mechanism of their toxicity, has
been established in certain hormone-dependent cancers (1,2). This study aimed to
determine Cd and Pb levels in blood, tumor and healthy surrounding tissue of patients with
breast, prostate and testis cancer and investigate the correlation of Cd and Pb with sex
hormone levels in the patient's blood. The study involved 55 breast, 41 prostate and 52 testis
cancer patients, while healthy women (41) and men (61) represented control groups.
Electrothermal atomic absorption spectrophotometry was used for Cd and Pb levels
determination. Significantly higher Cd levels, i.e. lower Pb in tumor tissue compared to the
healthy surrounding tissue were found in patients with breast cancer. A positive correlation
was confirmed between Cd levels in the changed tissue and both human gonadotropins, and
a negative correlation with estradiol, as well between Pb in tumor tissue and testosterone
levels. Patients with prostate and testis cancer were characterized by significantly higher
blood Cd levels compared to healthy subjects. Furthermore, significant Cd and Pb tumor
tissue accumulation was shown in prostate and testis cancer patients. A significant positive
correlation was found between blood Cd and estradiol levels in patients with prostate
cancer. The study highlighted higher Cd level as a significant predictor of cancer, and
confirmed impaired sex hormone homeostasis as pivotal mechanism of toxicity underlying
the toxic effects of Cd and Pb in patients with breast, prostate and testis cancer., Endokrini potencijal kadmijuma (Cd) i olova (Pb), kao važan mehanizam toksičnosti
oba metala, potvrđen je kod određenih hormon-zavisnih karcinoma (1,2). Ova studija je
imala za cilj da utvrdi koncentracije Cd i Pb u krvi, tumorskom i okolnom zdravom tkivu
pacijenata sa karcinomom dojke, prostate i testisa i ispita korelaciju Cd i Pb sa nivoom polnih
hormona u krvi pacijenata. Obuhvatila je 55 pacijentkinja sa karcinomom dojke, 41 pacijenta
sa karcinomom prostate i 52 pacijenta sa karcinomom testisa, dok su u kontrolnu grupu bile
uključene zdrave žene (41) i zdravi muškarci (61). Koncentracije Cd i Pb su analizirane
elektrotermalnom atomskom apsorpcionom spektrofotometrijom. Značajno više
koncentracije Cd, odnosno niže Pb u tumorskom u odnosu na okolno zdravo tkivo utvrđene
su kod pacijentkinja sa karcinomom dojke. Pozitivna korelacija je potvrđena između
koncentracija Cd u tkivu izmenjene strukture i oba humana gonadotropina, a negativna sa
estradiolom, te između Pb u tumorskom tkivu i testosterona. Pacijente sa karcinomom
prostate i testisa karakterisale su značajno više koncentracije Cd u krvi u odnosu na zdrave
ispitanike, a pokazana je i značajna akumulacija Cd i Pb u tumorskom tkivu prostate i testisa.
Značajna pozitivna korelacija utvrđena je između koncentracije Cd i estradiola u krvi kod
pacijenata sa karcinom prostate. Studija je pokazala da su više koncentracije Cd značajan
prediktor za nastanak karcinoma i potvrdilanarušenu homeostazu polnih hormona kao
važan mehanizam toksičnosti koji se nalazi u osnovi toksičnih efekata Cd i Pb kod obolelih od
karcinoma dojke, prostate i testisa.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?, Narušena homeostaza polnih hormona kod pacijenata sa karcinom dojke, prostate i testisa: koja je uloga kadmijuma i olova",
volume = "72",
number = "4 suplement",
pages = "S211-S212",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4497"
}

Anđelković, M., Buha-Đorđević, A., Javorac, D., Baralić, K., Đukić-Ćosić, D., Antonijević, B., Ćurčić, M., Antonijević-Miljaković, E., Čolaković, N., Aćimović, M.,& Bulat, Z.. (2022). Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S211-S212.
https://hdl.handle.net/21.15107/rcub_farfar_4497

Anđelković M, Buha-Đorđević A, Javorac D, Baralić K, Đukić-Ćosić D, Antonijević B, Ćurčić M, Antonijević-Miljaković E, Čolaković N, Aćimović M, Bulat Z. Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?. in Arhiv za farmaciju. 2022;72(4 suplement):S211-S212.
https://hdl.handle.net/21.15107/rcub_farfar_4497 .

Anđelković, Milena, Buha-Đorđević, Aleksandra, Javorac, Dragana, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević, Biljana, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Čolaković, Nataša, Aćimović, Miodrag, Bulat, Zorica, "Impaired sex hormone homeostasis in patients with breast, prostate and testis cancer: What is the role of cadmium and lead?" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S211-S212,
https://hdl.handle.net/21.15107/rcub_farfar_4497 .

TY  - CONF
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Anđelković, Milena
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4496
AB  - Lead (Pb) is one of the most important toxic metals without known physiological role.
Recent data indicate that any exposure, even low, can be harmful. Therefore, safe blood lead
levels, as well as tolerating daily intake, have not been identified. In adults, the most sensitive
effect is increase in systolic blood pressure, while in children, the most sensitive effect is on
cognition. Therefore, the aim of this study was to examine the effects of low lead doses on the
central nervous and cardiovascular system in a rat model. The study was conducted on
Wistar rats (n = 42; 7 groups) treated for 28 days, with increasing doses of 0.1; 0.5; 1; 3; 7;
15 mgPb/kg b.w./day to simulate real exposure. After the sacrifice, the brain and heart were
isolated, in which the parameters of oxidative status, bioelements and lead levels were
determined. Benchmark modelling of the dose-effect relationship was performed using
PROAST 70.1 software (RIVM, Netherlands). The obtained results indicate that lead leads to
the induction of oxidative stress and dishomeostasis of bioelements. The lowest value of the
Benchmark dose (BMD) was obtained for increase the total oxidative status in the brain
(4.49e-06 mgPb/kg/b.w./day), which is the most sensitive effect. In the case of heart, the
most sensitive effect was increase in malondialdehyde (BMD: 0.000248 mgPb/kg/b.w./day).
Obtained results indicate that low lead doses have toxic effects on heart and brain. Obtained
BMD may be useful in assessing human health risk of low lead dose exposure.
AB  - Olovo (Pb) je jedan od najznačajnijih toksičnih metala bez poznate fiziološke uloge u
organizmu. Novija istraživanja ukazuju da potencijalno svaka izloženost olovu, čak i niskim
dozama, može biti štetna, te tolerišući dnevni unos, kao ni bezbedan nivo u krvi, nisu
utvrđeni. Kod odraslih, kao najosetljiviji efekat izdvaja se povećanje sistolnog krvnog
pritiska, dok je kod dece to poremećaj kognicije. Imajući navedeno u vidu, cilj ove studije bio
je da se na animalnom modelu ispita uticaj niskih doza olova na centralni nervni i
kardiovaskularni sistem, koji su do sada identifikovani kao najosetljiviji na dejstvo olova, i
odrede Benchmark doze (BMD). Studija je sprovedena na modelu Wistar pacova koji su
podeljeni u 7 grupa tretiranih tokom 28 dana rastućim dozama olova 0, 0,1; 0,5; 1; 3; 7; 15
mg Pb/kg t.m./dan kako bi se simulirala realna izloženost. Nakon žrtvovanja pacova,
izolovani su mozak i srce u kojima su određeni olovo, bioelementi i parametri oksidativnog
statusa. Benchmark modelovanje odnosa doza-efekat vršeno je pomoću PROAST 70.1
softvera (RIVM, Holandija). Dobijeni rezultati ukazuju da olovo dovodi do indukcije
oksidativnog stresa i poremećaja homeostaze bioelemenata. Najniža BMD dobijena je za
povećanje totalnog oksidativnog statusa u mozgu (4,49e-06 mg Pb/kg t.m./dan), što
predstavlja najosetljiviji efekat, a u srcu je to povećanje koncentracije malondialdehida
(BMD: 0,000248 mg Pb/kg t.m./dan). Dobijeni rezultati ukazuju da i niske doze olova mogu
ispoljiti toksične efekte na srce i mozak, a dobijene BMD su od značaja za procenu rizika
olova po zdravlje ljudi.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Old lead, new challenges: Is there a safe level of exposure?
T1  - Staro olovo, novi izazovi: postoji li bezbedan nivo izloženosti?
VL  - 72
IS  - 4 suplement
SP  - S209
EP  - S210
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4496
ER  - 

@conference{
author = "Javorac, Dragana and Marić, Đurđica and Baralić, Katarina and Anđelković, Milena and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2022",
abstract = "Lead (Pb) is one of the most important toxic metals without known physiological role.
Recent data indicate that any exposure, even low, can be harmful. Therefore, safe blood lead
levels, as well as tolerating daily intake, have not been identified. In adults, the most sensitive
effect is increase in systolic blood pressure, while in children, the most sensitive effect is on
cognition. Therefore, the aim of this study was to examine the effects of low lead doses on the
central nervous and cardiovascular system in a rat model. The study was conducted on
Wistar rats (n = 42; 7 groups) treated for 28 days, with increasing doses of 0.1; 0.5; 1; 3; 7;
15 mgPb/kg b.w./day to simulate real exposure. After the sacrifice, the brain and heart were
isolated, in which the parameters of oxidative status, bioelements and lead levels were
determined. Benchmark modelling of the dose-effect relationship was performed using
PROAST 70.1 software (RIVM, Netherlands). The obtained results indicate that lead leads to
the induction of oxidative stress and dishomeostasis of bioelements. The lowest value of the
Benchmark dose (BMD) was obtained for increase the total oxidative status in the brain
(4.49e-06 mgPb/kg/b.w./day), which is the most sensitive effect. In the case of heart, the
most sensitive effect was increase in malondialdehyde (BMD: 0.000248 mgPb/kg/b.w./day).
Obtained results indicate that low lead doses have toxic effects on heart and brain. Obtained
BMD may be useful in assessing human health risk of low lead dose exposure., Olovo (Pb) je jedan od najznačajnijih toksičnih metala bez poznate fiziološke uloge u
organizmu. Novija istraživanja ukazuju da potencijalno svaka izloženost olovu, čak i niskim
dozama, može biti štetna, te tolerišući dnevni unos, kao ni bezbedan nivo u krvi, nisu
utvrđeni. Kod odraslih, kao najosetljiviji efekat izdvaja se povećanje sistolnog krvnog
pritiska, dok je kod dece to poremećaj kognicije. Imajući navedeno u vidu, cilj ove studije bio
je da se na animalnom modelu ispita uticaj niskih doza olova na centralni nervni i
kardiovaskularni sistem, koji su do sada identifikovani kao najosetljiviji na dejstvo olova, i
odrede Benchmark doze (BMD). Studija je sprovedena na modelu Wistar pacova koji su
podeljeni u 7 grupa tretiranih tokom 28 dana rastućim dozama olova 0, 0,1; 0,5; 1; 3; 7; 15
mg Pb/kg t.m./dan kako bi se simulirala realna izloženost. Nakon žrtvovanja pacova,
izolovani su mozak i srce u kojima su određeni olovo, bioelementi i parametri oksidativnog
statusa. Benchmark modelovanje odnosa doza-efekat vršeno je pomoću PROAST 70.1
softvera (RIVM, Holandija). Dobijeni rezultati ukazuju da olovo dovodi do indukcije
oksidativnog stresa i poremećaja homeostaze bioelemenata. Najniža BMD dobijena je za
povećanje totalnog oksidativnog statusa u mozgu (4,49e-06 mg Pb/kg t.m./dan), što
predstavlja najosetljiviji efekat, a u srcu je to povećanje koncentracije malondialdehida
(BMD: 0,000248 mg Pb/kg t.m./dan). Dobijeni rezultati ukazuju da i niske doze olova mogu
ispoljiti toksične efekte na srce i mozak, a dobijene BMD su od značaja za procenu rizika
olova po zdravlje ljudi.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Old lead, new challenges: Is there a safe level of exposure?, Staro olovo, novi izazovi: postoji li bezbedan nivo izloženosti?",
volume = "72",
number = "4 suplement",
pages = "S209-S210",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4496"
}

Javorac, D., Marić, Đ., Baralić, K., Anđelković, M., Antonijević-Miljaković, E., Buha-Đorđević, A., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2022). Old lead, new challenges: Is there a safe level of exposure?. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S209-S210.
https://hdl.handle.net/21.15107/rcub_farfar_4496

Javorac D, Marić Đ, Baralić K, Anđelković M, Antonijević-Miljaković E, Buha-Đorđević A, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Old lead, new challenges: Is there a safe level of exposure?. in Arhiv za farmaciju. 2022;72(4 suplement):S209-S210.
https://hdl.handle.net/21.15107/rcub_farfar_4496 .

Javorac, Dragana, Marić, Đurđica, Baralić, Katarina, Anđelković, Milena, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Old lead, new challenges: Is there a safe level of exposure?" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S209-S210,
https://hdl.handle.net/21.15107/rcub_farfar_4496 .

TY  - CONF
AU  - Đukić-Ćosić, Danijela
AU  - Baralić, Katarina
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Anđelković, Milena
AU  - Ćurčić, Marijana
AU  - Repić, Aleksandra
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
AU  - Buha-Đorđević, Aleksandra
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4346
PB  - Elsevier B.V.
C3  - Toxicology Letters
T1  - The linkage between cadmium and insulin resistance - integrating bioinformatics approach with Benchmark modeling of human data
VL  - 368
IS  - Supplement
SP  - S277
EP  - S277
DO  - 10.1016/j.toxlet.2022.07.732
ER  - 

@conference{
author = "Đukić-Ćosić, Danijela and Baralić, Katarina and Javorac, Dragana and Marić, Đurđica and Anđelković, Milena and Ćurčić, Marijana and Repić, Aleksandra and Antonijević, Biljana and Bulat, Zorica and Buha-Đorđević, Aleksandra",
year = "2022",
publisher = "Elsevier B.V.",
journal = "Toxicology Letters",
title = "The linkage between cadmium and insulin resistance - integrating bioinformatics approach with Benchmark modeling of human data",
volume = "368",
number = "Supplement",
pages = "S277-S277",
doi = "10.1016/j.toxlet.2022.07.732"
}

Đukić-Ćosić, D., Baralić, K., Javorac, D., Marić, Đ., Anđelković, M., Ćurčić, M., Repić, A., Antonijević, B., Bulat, Z.,& Buha-Đorđević, A.. (2022). The linkage between cadmium and insulin resistance - integrating bioinformatics approach with Benchmark modeling of human data. in Toxicology Letters
Elsevier B.V.., 368(Supplement), S277-S277.
https://doi.org/10.1016/j.toxlet.2022.07.732

Đukić-Ćosić D, Baralić K, Javorac D, Marić Đ, Anđelković M, Ćurčić M, Repić A, Antonijević B, Bulat Z, Buha-Đorđević A. The linkage between cadmium and insulin resistance - integrating bioinformatics approach with Benchmark modeling of human data. in Toxicology Letters. 2022;368(Supplement):S277-S277.
doi:10.1016/j.toxlet.2022.07.732 .

Đukić-Ćosić, Danijela, Baralić, Katarina, Javorac, Dragana, Marić, Đurđica, Anđelković, Milena, Ćurčić, Marijana, Repić, Aleksandra, Antonijević, Biljana, Bulat, Zorica, Buha-Đorđević, Aleksandra, "The linkage between cadmium and insulin resistance - integrating bioinformatics approach with Benchmark modeling of human data" in Toxicology Letters, 368, no. Supplement (2022):S277-S277,
https://doi.org/10.1016/j.toxlet.2022.07.732 . .

TY  - JOUR
AU  - Javorac, Dragana
AU  - Tatović, Simona
AU  - Anđelković, Milena
AU  - Repić, Aleksandra
AU  - Baralić, Katarina
AU  - Buha-Đorđević, Aleksandra
AU  - Mihajlović, Marija
AU  - Kotur-Stevuljević, Jelena
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4046
AB  - Exposure to toxic metals, including lead (Pb), were found as important risk factor for cardiovascular diseases. The aim of the study was to simulate low-level subacute Pb exposure scenario and to determine redox status, redox scores (OXY-score, damage score and protective score) and copper (Cu), zinc (Zn), iron (Fe) and manganese (Mn) levels in cardiac tissue of Wistar rats. Based on the obtained results we have established dose-toxic response relationship and derived Benchmark dose. The male Wistar rats were divided in seven groups (n = 6), six threated groups that received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, by oral gavage and control group. The results of the presented study demonstrated that Pb affect cardiac tissue by inducing production of superoxide anion radical (O2.-) and consequently raising malondialdehyde (MDA) levels. The positive trend in OXY-score and damage score were determined. Effect size analysis showed that the main toxic effects were oxidative damage and elevation of MDA. The lowest BMD was calculated for MDA (2.2e-0.6 mg Pb/kg b.w./day). Obtained BMD may be useful in further assessing point of departure in the human health risks assessment of low-level Pb exposure scenario.
PB  - Elsevier Ltd
T2  - Food and Chemical Toxicology
T1  - Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling
VL  - 161
DO  - 10.1016/j.fct.2022.112825
ER  - 

@article{
author = "Javorac, Dragana and Tatović, Simona and Anđelković, Milena and Repić, Aleksandra and Baralić, Katarina and Buha-Đorđević, Aleksandra and Mihajlović, Marija and Kotur-Stevuljević, Jelena and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2022",
abstract = "Exposure to toxic metals, including lead (Pb), were found as important risk factor for cardiovascular diseases. The aim of the study was to simulate low-level subacute Pb exposure scenario and to determine redox status, redox scores (OXY-score, damage score and protective score) and copper (Cu), zinc (Zn), iron (Fe) and manganese (Mn) levels in cardiac tissue of Wistar rats. Based on the obtained results we have established dose-toxic response relationship and derived Benchmark dose. The male Wistar rats were divided in seven groups (n = 6), six threated groups that received 0.1; 0.5; 1; 3; 7; 15 mg Pb/kg body weight/day for 28 days, by oral gavage and control group. The results of the presented study demonstrated that Pb affect cardiac tissue by inducing production of superoxide anion radical (O2.-) and consequently raising malondialdehyde (MDA) levels. The positive trend in OXY-score and damage score were determined. Effect size analysis showed that the main toxic effects were oxidative damage and elevation of MDA. The lowest BMD was calculated for MDA (2.2e-0.6 mg Pb/kg b.w./day). Obtained BMD may be useful in further assessing point of departure in the human health risks assessment of low-level Pb exposure scenario.",
publisher = "Elsevier Ltd",
journal = "Food and Chemical Toxicology",
title = "Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling",
volume = "161",
doi = "10.1016/j.fct.2022.112825"
}

Javorac, D., Tatović, S., Anđelković, M., Repić, A., Baralić, K., Buha-Đorđević, A., Mihajlović, M., Kotur-Stevuljević, J., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2022). Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling. in Food and Chemical Toxicology
Elsevier Ltd., 161.
https://doi.org/10.1016/j.fct.2022.112825

Javorac D, Tatović S, Anđelković M, Repić A, Baralić K, Buha-Đorđević A, Mihajlović M, Kotur-Stevuljević J, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling. in Food and Chemical Toxicology. 2022;161.
doi:10.1016/j.fct.2022.112825 .

Javorac, Dragana, Tatović, Simona, Anđelković, Milena, Repić, Aleksandra, Baralić, Katarina, Buha-Đorđević, Aleksandra, Mihajlović, Marija, Kotur-Stevuljević, Jelena, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "Low-lead doses induce oxidative damage in cardiac tissue: Subacute toxicity study in Wistar rats and Benchmark dose modelling" in Food and Chemical Toxicology, 161 (2022),
https://doi.org/10.1016/j.fct.2022.112825 . .

TY  - CONF
AU  - Petrović, Bojana
AU  - Gladović, Ana
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Šoštarić, Andrej
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4643
AB  - One of the most polluted cities in Serbia and Europe is Bor, due to mining and
smelting processes in Mining-Metallurgical Complex in Bor. Mining activities release mainly
SO2 and paritculate matter in air (1) and, as arsenic is usually found in copper and lead ores,
air quality monitoring in Bor has been showing its presence in exceeded annual limit
concentrations in past few years. Exposure to arsenic is related with anemia, skin changes,
peripheral neuropathy and cancer development. This study was carried out to assess
children’s and adult’s exposure to arsenic bound to PM10 and to charcterize risk from their
exposure through the air in the city of Bor. Mean yearly concentrations of arsenic were used
from Reports of the Serbian Enviromental Protection Agency, for measuring stations: Bor-
City park, Bor 1, Bor 2 and Bor-Jugopetrol. The USEPA method was used to assess non-
carcinogenic and carcinogenic risk, which classifies non-carcinogenic risk as acceptable (<1)
or unacceptable (>1) based on hazard quotient (HQ) values for three main exposure
pathways, while cancer risk classification is based on CR values also as acceptable (<1×10 -4 )
or unacceptable (>1×10 -4 ) (2). HQinh values exceeded safe level both for children and adults
on all measuring stations, describing risk as unacceptable via inhalation exposure.
Unacceptable carcinogenic risk for children was calculated on measuring station Bor-
Jugopetrol and for adults on measuring stations Bor-City park, Bor 1 and Bor-Jugopetrol.
Actions for reduction of arsenic release into the air should be taken due to obtained results
for city of Bor.
AB  - Grad Bor spada među najzagađenije gradove u Republici Srbiji i Evropi. Najveći izvor
zagađenja u ovom gradu predstavlja rudnik bakra, Rudarsko-topioničarski basen Bor, usled
emisije, predominantno, SO2 i suspendovanih čestica (1). Arsen je čest pratilac ruda bakra i
olova, te se iz godine u godinu monitoringom kvaliteta vazduha uočava njegovo prisustvo u
koncentracijama koje prelaze dozvoljene godišnje granice. Izloženost arsenu može dovesti
do razvoja anemije, promena na koži, periferne neuropatije, ali i razvoja karcinoma. Cilj rada
bio je da se proceni izloženost i okarakteriše rizik dece i odraslih od izloženosti arsenu iz
PM10 čestica tj. putem zagađenog vazduha u gradu Boru. Vrednosti prosečnih godišnjih
koncentracija arsena u vazduhu su preuzete iz godišnjih izveštaja Agencije za zaštitu životne
sredine, za merne stanice: Bor-Gradski park, Bor 1, Bor 2 i Bor-Jugopetrol. Zdravstveni rizik
je procenjen metodologijom koju preporučuje Američka agencija za zaštitu životne sredine.
Na osnovu vrednosti količnika hazarda (HQ) za oralni, inhalacioni i dermalni put unosa, ne-
karcinogeni rizik se klasifikuje kao prihvatljiv (<1) ili neprihvatljiv (>1), dok se karcinogeni
rizik klasifikuje na osnovu vrednosti CR, takođe kao prihvatljiv (<1×10-4 ) ili neprihvaljiv
(>1×10 -4 ) (2). Izračunate vrednosti HQinh za decu i odrasle prelaze vrednost 1 ukazujući na
neprihvatljiv rizik od izloženosti arsenu preko PM10 čestica iz zagađenog vazduha na svim
razmatranim mernim stanicama. Neprihvatljiv karcinogeni rizik za decu je izračunat na
stanici Bor-Jugopetrol, a za odrasle na stanicama Bor-Gradski park, Bor 1 i Bor-Jugopetrol.
Dobijeni rezultati ukazuju na preku potrebu preduzimanja mera u cilju smanjenja emisije
arsena u vazduh u Boru.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Health risk assessment of children’s and adult’s exposure to arsenic bound to PM10 in the city of Bor
T1  - Procena rizika od izloženosti dece i odraslih arsenu u PM10 česticama putem zagađenog vazduha u Boru
VL  - 72
IS  - 4 suplement
SP  - S615
EP  - S616
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4643
ER  - 

@conference{
author = "Petrović, Bojana and Gladović, Ana and Javorac, Dragana and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Šoštarić, Andrej and Antonijević, Biljana and Bulat, Zorica",
year = "2022",
abstract = "One of the most polluted cities in Serbia and Europe is Bor, due to mining and
smelting processes in Mining-Metallurgical Complex in Bor. Mining activities release mainly
SO2 and paritculate matter in air (1) and, as arsenic is usually found in copper and lead ores,
air quality monitoring in Bor has been showing its presence in exceeded annual limit
concentrations in past few years. Exposure to arsenic is related with anemia, skin changes,
peripheral neuropathy and cancer development. This study was carried out to assess
children’s and adult’s exposure to arsenic bound to PM10 and to charcterize risk from their
exposure through the air in the city of Bor. Mean yearly concentrations of arsenic were used
from Reports of the Serbian Enviromental Protection Agency, for measuring stations: Bor-
City park, Bor 1, Bor 2 and Bor-Jugopetrol. The USEPA method was used to assess non-
carcinogenic and carcinogenic risk, which classifies non-carcinogenic risk as acceptable (<1)
or unacceptable (>1) based on hazard quotient (HQ) values for three main exposure
pathways, while cancer risk classification is based on CR values also as acceptable (<1×10 -4 )
or unacceptable (>1×10 -4 ) (2). HQinh values exceeded safe level both for children and adults
on all measuring stations, describing risk as unacceptable via inhalation exposure.
Unacceptable carcinogenic risk for children was calculated on measuring station Bor-
Jugopetrol and for adults on measuring stations Bor-City park, Bor 1 and Bor-Jugopetrol.
Actions for reduction of arsenic release into the air should be taken due to obtained results
for city of Bor., Grad Bor spada među najzagađenije gradove u Republici Srbiji i Evropi. Najveći izvor
zagađenja u ovom gradu predstavlja rudnik bakra, Rudarsko-topioničarski basen Bor, usled
emisije, predominantno, SO2 i suspendovanih čestica (1). Arsen je čest pratilac ruda bakra i
olova, te se iz godine u godinu monitoringom kvaliteta vazduha uočava njegovo prisustvo u
koncentracijama koje prelaze dozvoljene godišnje granice. Izloženost arsenu može dovesti
do razvoja anemije, promena na koži, periferne neuropatije, ali i razvoja karcinoma. Cilj rada
bio je da se proceni izloženost i okarakteriše rizik dece i odraslih od izloženosti arsenu iz
PM10 čestica tj. putem zagađenog vazduha u gradu Boru. Vrednosti prosečnih godišnjih
koncentracija arsena u vazduhu su preuzete iz godišnjih izveštaja Agencije za zaštitu životne
sredine, za merne stanice: Bor-Gradski park, Bor 1, Bor 2 i Bor-Jugopetrol. Zdravstveni rizik
je procenjen metodologijom koju preporučuje Američka agencija za zaštitu životne sredine.
Na osnovu vrednosti količnika hazarda (HQ) za oralni, inhalacioni i dermalni put unosa, ne-
karcinogeni rizik se klasifikuje kao prihvatljiv (<1) ili neprihvatljiv (>1), dok se karcinogeni
rizik klasifikuje na osnovu vrednosti CR, takođe kao prihvatljiv (<1×10-4 ) ili neprihvaljiv
(>1×10 -4 ) (2). Izračunate vrednosti HQinh za decu i odrasle prelaze vrednost 1 ukazujući na
neprihvatljiv rizik od izloženosti arsenu preko PM10 čestica iz zagađenog vazduha na svim
razmatranim mernim stanicama. Neprihvatljiv karcinogeni rizik za decu je izračunat na
stanici Bor-Jugopetrol, a za odrasle na stanicama Bor-Gradski park, Bor 1 i Bor-Jugopetrol.
Dobijeni rezultati ukazuju na preku potrebu preduzimanja mera u cilju smanjenja emisije
arsena u vazduh u Boru.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Health risk assessment of children’s and adult’s exposure to arsenic bound to PM10 in the city of Bor, Procena rizika od izloženosti dece i odraslih arsenu u PM10 česticama putem zagađenog vazduha u Boru",
volume = "72",
number = "4 suplement",
pages = "S615-S616",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4643"
}

Petrović, B., Gladović, A., Javorac, D., Buha-Đorđević, A., Ćurčić, M., Đukić-Ćosić, D., Šoštarić, A., Antonijević, B.,& Bulat, Z.. (2022). Health risk assessment of children’s and adult’s exposure to arsenic bound to PM10 in the city of Bor. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S615-S616.
https://hdl.handle.net/21.15107/rcub_farfar_4643

Petrović B, Gladović A, Javorac D, Buha-Đorđević A, Ćurčić M, Đukić-Ćosić D, Šoštarić A, Antonijević B, Bulat Z. Health risk assessment of children’s and adult’s exposure to arsenic bound to PM10 in the city of Bor. in Arhiv za farmaciju. 2022;72(4 suplement):S615-S616.
https://hdl.handle.net/21.15107/rcub_farfar_4643 .

Petrović, Bojana, Gladović, Ana, Javorac, Dragana, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Šoštarić, Andrej, Antonijević, Biljana, Bulat, Zorica, "Health risk assessment of children’s and adult’s exposure to arsenic bound to PM10 in the city of Bor" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S615-S616,
https://hdl.handle.net/21.15107/rcub_farfar_4643 .

TY  - CONF
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Baralić, Katarina
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Đukić-Ćosić, Danijela
AU  - Ćurčić, Marijana
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4642
AB  - Polluted air is significant factor with a negative impact on human health. Solving the
problem of polluted air requires involvement of the health system and health workers,
among whom pharmacists in public pharmacies can stand out as the most accessible health
workers with the highest knowledge in the field of toxicology. Considering the indisputable
role of pharmacists in improving health and disease prevention, raising public awareness of
air pollution health impact and advising patients on activities in case of air pollution,
pharmacists would contribute to maintaining health, reducing the burden on the health
system and its efficiency and sustainability. The pharmaceutical profession can make a
significant contribution to combating the impact of air pollution on human health by
increasing the availability of guidelines in the case of polluted air, increasing the availability
of air quality monitoring tools, strengthening educational capacity models, participating in
regulatory frameworks and improving funding for pharmaceutical services. In order for
these responsibilities to be fully incorporated into pharmaceutical practice, it is necessary to:
implement education in the field of toxicology, both at basic and higher levels of study in
order to develop the necessary competencies; increase public awareness of the health
consequences of air pollution, as well as the new roles of pharmacists; develop appropriate
guidelines, regulatory and financial support as well as screening tools. With this in mind, the
role of pharmacists in reducing the impact of air pollution on human health should be
recognized and developed in order to protect human health.
AB  - Zagađen vazduh predstavlja značajan faktor koji ima negativan uticaj na zdravlje ljudi.
Rešavanje problema zagađenog vazduha zahteva uključivanje zdravstvenog sistema i
zdravstvenih radnika, među kojima se mogu istaći farmaceuti u javnim apotekama kao
najdostupniji zdravstveni radnici, sa najvišim znanjima iz oblasti toksikologije. Imajući u
vidu neospornu ulogu farmaceuta u unapređenju zdravlja i prevenciji bolesti, podizanjem
svesti javnosti o uticaju zagađenja vazduha na zdravlje ljudi i davanjem saveta pacijentima o
aktivnostima u slučaju zagađenja vazduha, farmaceuti bi doprineli očuvanju zdravlja,
smanjenju opterećenja zdravstvenog sistema i njegovoj efikasnosti i održivosti.
Farmaceutska profesija može značajno doprineti suzbijanju uticaja zagađenja vazduha na
zdravlje ljudi i to: povećanjem dostupnosti smernica u slučaju zagađenog vazduha,
povećanjem dostupnosti alata za monitoring kvaliteta vazduha, jačanjem obrazovnih
kapaciteta, učestvovanjem u donošenju regulatornih okvira i poboljšanjem modela
finansiranja farmaceutskih usluga kako bi se obezbedila održivost. Da bi navedene
odgovornosti bile u potpunosti inkorporirane u farmaceutsku praksu, potrebno je:
implementirati edukaciju iz oblasti toksikologije, kako na osnovnim tako i na višim nivoima
studija kako bi se razvile neophodne kompetencije; povećati svest javnosti o zdravstvenim
posledicama zagađenja vazduha, kao i o novim ulogama farmaceuta; razviti odgovarajuće
smernice, regulatornu i finansijsku podršku kao i alate za skrining. Imajući navedeno u vidu,
uloga farmaceuta u smanjenju uticaja zagađenja vazduha na zdravlje ljudi treba biti
prepoznata i razvijena sa ciljem očuvanja zdravlja.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - The role of pharmacist in reducing the impact of air pollution on human health
T1  - Uloga farmaceuta u smanjenju uticaja zagađenja vazduha na zdravlje ljudi
VL  - 72
IS  - 4 suplement
SP  - S613
EP  - S614
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4642
ER  - 

@conference{
author = "Javorac, Dragana and Marić, Đurđica and Baralić, Katarina and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Đukić-Ćosić, Danijela and Ćurčić, Marijana and Antonijević, Biljana and Bulat, Zorica",
year = "2022",
abstract = "Polluted air is significant factor with a negative impact on human health. Solving the
problem of polluted air requires involvement of the health system and health workers,
among whom pharmacists in public pharmacies can stand out as the most accessible health
workers with the highest knowledge in the field of toxicology. Considering the indisputable
role of pharmacists in improving health and disease prevention, raising public awareness of
air pollution health impact and advising patients on activities in case of air pollution,
pharmacists would contribute to maintaining health, reducing the burden on the health
system and its efficiency and sustainability. The pharmaceutical profession can make a
significant contribution to combating the impact of air pollution on human health by
increasing the availability of guidelines in the case of polluted air, increasing the availability
of air quality monitoring tools, strengthening educational capacity models, participating in
regulatory frameworks and improving funding for pharmaceutical services. In order for
these responsibilities to be fully incorporated into pharmaceutical practice, it is necessary to:
implement education in the field of toxicology, both at basic and higher levels of study in
order to develop the necessary competencies; increase public awareness of the health
consequences of air pollution, as well as the new roles of pharmacists; develop appropriate
guidelines, regulatory and financial support as well as screening tools. With this in mind, the
role of pharmacists in reducing the impact of air pollution on human health should be
recognized and developed in order to protect human health., Zagađen vazduh predstavlja značajan faktor koji ima negativan uticaj na zdravlje ljudi.
Rešavanje problema zagađenog vazduha zahteva uključivanje zdravstvenog sistema i
zdravstvenih radnika, među kojima se mogu istaći farmaceuti u javnim apotekama kao
najdostupniji zdravstveni radnici, sa najvišim znanjima iz oblasti toksikologije. Imajući u
vidu neospornu ulogu farmaceuta u unapređenju zdravlja i prevenciji bolesti, podizanjem
svesti javnosti o uticaju zagađenja vazduha na zdravlje ljudi i davanjem saveta pacijentima o
aktivnostima u slučaju zagađenja vazduha, farmaceuti bi doprineli očuvanju zdravlja,
smanjenju opterećenja zdravstvenog sistema i njegovoj efikasnosti i održivosti.
Farmaceutska profesija može značajno doprineti suzbijanju uticaja zagađenja vazduha na
zdravlje ljudi i to: povećanjem dostupnosti smernica u slučaju zagađenog vazduha,
povećanjem dostupnosti alata za monitoring kvaliteta vazduha, jačanjem obrazovnih
kapaciteta, učestvovanjem u donošenju regulatornih okvira i poboljšanjem modela
finansiranja farmaceutskih usluga kako bi se obezbedila održivost. Da bi navedene
odgovornosti bile u potpunosti inkorporirane u farmaceutsku praksu, potrebno je:
implementirati edukaciju iz oblasti toksikologije, kako na osnovnim tako i na višim nivoima
studija kako bi se razvile neophodne kompetencije; povećati svest javnosti o zdravstvenim
posledicama zagađenja vazduha, kao i o novim ulogama farmaceuta; razviti odgovarajuće
smernice, regulatornu i finansijsku podršku kao i alate za skrining. Imajući navedeno u vidu,
uloga farmaceuta u smanjenju uticaja zagađenja vazduha na zdravlje ljudi treba biti
prepoznata i razvijena sa ciljem očuvanja zdravlja.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "The role of pharmacist in reducing the impact of air pollution on human health, Uloga farmaceuta u smanjenju uticaja zagađenja vazduha na zdravlje ljudi",
volume = "72",
number = "4 suplement",
pages = "S613-S614",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4642"
}

Javorac, D., Marić, Đ., Baralić, K., Antonijević-Miljaković, E., Buha-Đorđević, A., Đukić-Ćosić, D., Ćurčić, M., Antonijević, B.,& Bulat, Z.. (2022). The role of pharmacist in reducing the impact of air pollution on human health. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S613-S614.
https://hdl.handle.net/21.15107/rcub_farfar_4642

Javorac D, Marić Đ, Baralić K, Antonijević-Miljaković E, Buha-Đorđević A, Đukić-Ćosić D, Ćurčić M, Antonijević B, Bulat Z. The role of pharmacist in reducing the impact of air pollution on human health. in Arhiv za farmaciju. 2022;72(4 suplement):S613-S614.
https://hdl.handle.net/21.15107/rcub_farfar_4642 .

Javorac, Dragana, Marić, Đurđica, Baralić, Katarina, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Đukić-Ćosić, Danijela, Ćurčić, Marijana, Antonijević, Biljana, Bulat, Zorica, "The role of pharmacist in reducing the impact of air pollution on human health" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S613-S614,
https://hdl.handle.net/21.15107/rcub_farfar_4642 .

TY  - CONF
AU  - Šuić, Ana
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đorđević, Snežana
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4640
AB  - According to the current regulations in Serbia, the cultivation and sale of hemp-based
products (Cannabis sativa L.) containing up to 0.3% of substances from the group of
tetrahydrocannabinol is allowed. ∆-9-tetrahydrocannabinol (THC) is responsible for the
psychoactive effects and the development of cannabis addiction. A growing number of products
based on parts or the whole cannabis plant are on free sale. Since cannabis is the most
commonly used psychoactive substance, there is a greater need for quick and easy detection
in the body. The Aim of this project was to examine the effect of commercial cannabis-based
products consuption on urine THC detection by using immunochromatographic test strips.
Eight healthy volunteers consumed commercially available hemp-based products (four tea
products, two ground and two whole seeds products). The products were consumed according to
the instructions given by the manufacturer, for three consecutive days, and on the fourth day the
first morning urine was tested for the presence of THC using multicomponent One Step Rapid
Test®-Ameritek® test strips. Urine samples from five subjects gave a negative test result, and three
samples, from subjects who consumed hemp ground seeds and tea in bulk, gave a positive THC
test. Further analysis of positive urine samples by the conformative method (HPLC-PDA) did not
prove the presence of THC. Consumption of certain commercial cannabis-based products can lead
to false-positive results in the detection of THC in urine by immunochromatographic test strips.
Therefore, it is necessary to perform further analysis of urine by conformative methods.
AB  - Prema važećoj regulativi u Srbiji je dozvoljeno gajenje i prodaja proizvoda na bazi
konoplje (Cannabis sativa L.) koji sadrže do 0,3% supstanci iz grupe tetrahidrokanabinola od
kojih se ∆-9-tetrahidrokanabinolu (THC) pripisuju psihoaktivni efekti i razvoj zavisnosti
povezan sa zloupotrebom kanabisa. U slobodnoj prodaji se nalazi sve veći broj proizvoda
baziranih na delovima ili celoj biljci kanabisa. S obzirom na to da je kanabis najčešće
korišćena psihoaktivna supstanca postoji i veća potreba za brzom i lakom detekcijom u
organizmu. Cilj ovog rada je ispitati uticaj konzumiranja komercijalnih proizvoda na bazi
konoplje na dokazivanje THC u urinu imunohromatografskim test trakama (1,2). U
ispitivanje je uključeno osam zdravih dobrovoljaca koji su konzumirali komercijalno
dostupne preparate na bazi konoplje (četiri čaja, dva mlevena i dva cela semena). Preparati
su konzumirani prema uputstvu datom od strane proizvođača, tri uzastopna dana, a četvrtog
dana je vršeno testiranje prvog jutarnjeg urina na prisustvo THC, upotrebom
višekomponentnih One Step Rapid Test®‐Ameritek® test traka. Uzorci pet ispitanika su dali
negativan rezultat testa, a tri uzorka, poreklom od ispitanika koji su konzumirali mleveno
seme konoplje i čaj u rinfuzu, dala su pozitivan test na THC. Daljom analizom urina koji su
dali pozitivan rezultat, konfirmativnom metodom (HPLC-PDA) nije dokazano prisustvo THC.
Konzumacija pojedinih preparata na bazi konoplje, koji se mogu naći u slobodnoj prodaji,
može da dovede do pojave lažno pozitivnih rezultata pri dokazivanju THC u urinu
imunohromatografskim test trakama, zbog čega je neophodno izvršiti dalju analizu urina
konfirmativnim metodama.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Influence of consumption of commercial hemp-based products on the detection of tetrahydrocanabinol in urine by immunochromatographic test strips
T1  - Uticaj konzumiranja komercijalnih proizvoda na bazi konoplje na dokazivanje tetrahidrokanabinola imunohromatografskim test trakama u urinu
VL  - 72
IS  - 4 suplement
SP  - S605
EP  - S606
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4640
ER  - 

@conference{
author = "Šuić, Ana and Javorac, Dragana and Baralić, Katarina and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Đorđević, Snežana and Đukić-Ćosić, Danijela and Antonijević, Biljana and Bulat, Zorica",
year = "2022",
abstract = "According to the current regulations in Serbia, the cultivation and sale of hemp-based
products (Cannabis sativa L.) containing up to 0.3% of substances from the group of
tetrahydrocannabinol is allowed. ∆-9-tetrahydrocannabinol (THC) is responsible for the
psychoactive effects and the development of cannabis addiction. A growing number of products
based on parts or the whole cannabis plant are on free sale. Since cannabis is the most
commonly used psychoactive substance, there is a greater need for quick and easy detection
in the body. The Aim of this project was to examine the effect of commercial cannabis-based
products consuption on urine THC detection by using immunochromatographic test strips.
Eight healthy volunteers consumed commercially available hemp-based products (four tea
products, two ground and two whole seeds products). The products were consumed according to
the instructions given by the manufacturer, for three consecutive days, and on the fourth day the
first morning urine was tested for the presence of THC using multicomponent One Step Rapid
Test®-Ameritek® test strips. Urine samples from five subjects gave a negative test result, and three
samples, from subjects who consumed hemp ground seeds and tea in bulk, gave a positive THC
test. Further analysis of positive urine samples by the conformative method (HPLC-PDA) did not
prove the presence of THC. Consumption of certain commercial cannabis-based products can lead
to false-positive results in the detection of THC in urine by immunochromatographic test strips.
Therefore, it is necessary to perform further analysis of urine by conformative methods., Prema važećoj regulativi u Srbiji je dozvoljeno gajenje i prodaja proizvoda na bazi
konoplje (Cannabis sativa L.) koji sadrže do 0,3% supstanci iz grupe tetrahidrokanabinola od
kojih se ∆-9-tetrahidrokanabinolu (THC) pripisuju psihoaktivni efekti i razvoj zavisnosti
povezan sa zloupotrebom kanabisa. U slobodnoj prodaji se nalazi sve veći broj proizvoda
baziranih na delovima ili celoj biljci kanabisa. S obzirom na to da je kanabis najčešće
korišćena psihoaktivna supstanca postoji i veća potreba za brzom i lakom detekcijom u
organizmu. Cilj ovog rada je ispitati uticaj konzumiranja komercijalnih proizvoda na bazi
konoplje na dokazivanje THC u urinu imunohromatografskim test trakama (1,2). U
ispitivanje je uključeno osam zdravih dobrovoljaca koji su konzumirali komercijalno
dostupne preparate na bazi konoplje (četiri čaja, dva mlevena i dva cela semena). Preparati
su konzumirani prema uputstvu datom od strane proizvođača, tri uzastopna dana, a četvrtog
dana je vršeno testiranje prvog jutarnjeg urina na prisustvo THC, upotrebom
višekomponentnih One Step Rapid Test®‐Ameritek® test traka. Uzorci pet ispitanika su dali
negativan rezultat testa, a tri uzorka, poreklom od ispitanika koji su konzumirali mleveno
seme konoplje i čaj u rinfuzu, dala su pozitivan test na THC. Daljom analizom urina koji su
dali pozitivan rezultat, konfirmativnom metodom (HPLC-PDA) nije dokazano prisustvo THC.
Konzumacija pojedinih preparata na bazi konoplje, koji se mogu naći u slobodnoj prodaji,
može da dovede do pojave lažno pozitivnih rezultata pri dokazivanju THC u urinu
imunohromatografskim test trakama, zbog čega je neophodno izvršiti dalju analizu urina
konfirmativnim metodama.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Influence of consumption of commercial hemp-based products on the detection of tetrahydrocanabinol in urine by immunochromatographic test strips, Uticaj konzumiranja komercijalnih proizvoda na bazi konoplje na dokazivanje tetrahidrokanabinola imunohromatografskim test trakama u urinu",
volume = "72",
number = "4 suplement",
pages = "S605-S606",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4640"
}

Šuić, A., Javorac, D., Baralić, K., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Đorđević, S., Đukić-Ćosić, D., Antonijević, B.,& Bulat, Z.. (2022). Influence of consumption of commercial hemp-based products on the detection of tetrahydrocanabinol in urine by immunochromatographic test strips. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S605-S606.
https://hdl.handle.net/21.15107/rcub_farfar_4640

Šuić A, Javorac D, Baralić K, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Đorđević S, Đukić-Ćosić D, Antonijević B, Bulat Z. Influence of consumption of commercial hemp-based products on the detection of tetrahydrocanabinol in urine by immunochromatographic test strips. in Arhiv za farmaciju. 2022;72(4 suplement):S605-S606.
https://hdl.handle.net/21.15107/rcub_farfar_4640 .

Šuić, Ana, Javorac, Dragana, Baralić, Katarina, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Đorđević, Snežana, Đukić-Ćosić, Danijela, Antonijević, Biljana, Bulat, Zorica, "Influence of consumption of commercial hemp-based products on the detection of tetrahydrocanabinol in urine by immunochromatographic test strips" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S605-S606,
https://hdl.handle.net/21.15107/rcub_farfar_4640 .

TY  - CONF
AU  - Gladović, Ana
AU  - Petrović, Bojana
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Đukić-Ćosić, Danijela
AU  - Šoštarić, Andrej
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4638
AB  - PM10 particles present in excessive concentrations in polluted air can negatively affect
respiratory and cardiovascular system, whereas lead exposure shows adverse effects on
renal, hematological, immunological, reproductive and neurological system, especially in
children (1). This study was carried out to assess children’s exposure to PM 10 and lead
through the air in critical districts of Serbia. Mean yearly concentrations of PM10 and lead
were used from reports of the Serbian Enviromental Protection Agency, for selected
measuring sites in the cities of Subotica, Smederevo, Bor, Valjevo and Kraljevo. Measuring
sites were selected based on air quality (over-polluted air) and being close to places where
children spend their time during the day. The US EPA method was used to assess health risk,
which classifies risk as acceptable (≤1) or unacceptable (>1) based on hazard quotient (HQ)
and hazard index (HI) values (2). HQ for PM10 particles was higher than 1 in all critical
districts, indicating risk as unacceptable. Values of HI for lead were lower than 1 in all critical
districts, indicating risk as acceptable. Results are showing that actions for reduction of air
pollution in Serbia should be taken due to obtained results for particulate matter and lead.
AB  - PM10 čestice prisutne u prekomernim koncentracijama u zagađenom vazduhu
ispoljavaju štetne efekte na respiratorni i kardiovaskularni sistem, dok olovo negativno utiče
i na renalni, hematopoetski, endokrini, imunološki, reproduktivni i nervni sistem, naročito
kod dece (1). Cilj ovog rada bio je da se proceni izloženost dece PM10 česticama i olovu putem
zagađenog vazduha u kritičnim područjima Srbije. Vrednosti prosečnih godišnjih
koncentracija PM 10 čestica i olova su preuzete iz godišnjih izveštaja Agencije za zaštitu
životne sredine, za odabrane merne stanice u gradovima Subotica, Smederevo, Bor, Valjevo i
Kraljevo. Kriterijum za izbor područja, odnosno mernih stanica, bio je kvalitet vazduha
(prekomerno zagađen vazduh) i blizina mesta gde deca provode značajan deo vremena.
Zdravstveni rizik je procenjen metodologijom koju preporučuje Američka agencija za zaštitu
životne sredine. Na osnovu vrednosti količnika hazarda (HQ) i indeksa hazarda (HI) rizik se
klasifikuje kao prihvatljiv (≤1) ili neprihvatljiv (>1) (2). HQ za PM10 čestice prelazi vrednost 1
u svim razmatranim područjima, ukazujući na neprihvatljiv rizik dok su vrednosti HI za
olovo manje od 1 ukazujući na prihvatljiv rizik u svim područjima. Dobijeni rezultati ukazuju
na potrebu preduzimanja mera u cilju smanjenja zagađenja vazduha u Republici Srbiji na
osnovu izračunatog zdravstvenog rizika od izloženosti suspendovanim česticama i olovu.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Assessment of children’s exposure to air pollutant PM10 and lead in crtitical districts in the Republic of Serbia
T1  - Procena izloženosti dece PM10 česticama i olovu putem zagađenog vazduha u kritičnim područjima Srbije
VL  - 72
IS  - 4 suplement
SP  - S601
EP  - S602
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4638
ER  - 

@conference{
author = "Gladović, Ana and Petrović, Bojana and Javorac, Dragana and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Đukić-Ćosić, Danijela and Šoštarić, Andrej and Antonijević, Biljana and Bulat, Zorica",
year = "2022",
abstract = "PM10 particles present in excessive concentrations in polluted air can negatively affect
respiratory and cardiovascular system, whereas lead exposure shows adverse effects on
renal, hematological, immunological, reproductive and neurological system, especially in
children (1). This study was carried out to assess children’s exposure to PM 10 and lead
through the air in critical districts of Serbia. Mean yearly concentrations of PM10 and lead
were used from reports of the Serbian Enviromental Protection Agency, for selected
measuring sites in the cities of Subotica, Smederevo, Bor, Valjevo and Kraljevo. Measuring
sites were selected based on air quality (over-polluted air) and being close to places where
children spend their time during the day. The US EPA method was used to assess health risk,
which classifies risk as acceptable (≤1) or unacceptable (>1) based on hazard quotient (HQ)
and hazard index (HI) values (2). HQ for PM10 particles was higher than 1 in all critical
districts, indicating risk as unacceptable. Values of HI for lead were lower than 1 in all critical
districts, indicating risk as acceptable. Results are showing that actions for reduction of air
pollution in Serbia should be taken due to obtained results for particulate matter and lead., PM10 čestice prisutne u prekomernim koncentracijama u zagađenom vazduhu
ispoljavaju štetne efekte na respiratorni i kardiovaskularni sistem, dok olovo negativno utiče
i na renalni, hematopoetski, endokrini, imunološki, reproduktivni i nervni sistem, naročito
kod dece (1). Cilj ovog rada bio je da se proceni izloženost dece PM10 česticama i olovu putem
zagađenog vazduha u kritičnim područjima Srbije. Vrednosti prosečnih godišnjih
koncentracija PM 10 čestica i olova su preuzete iz godišnjih izveštaja Agencije za zaštitu
životne sredine, za odabrane merne stanice u gradovima Subotica, Smederevo, Bor, Valjevo i
Kraljevo. Kriterijum za izbor područja, odnosno mernih stanica, bio je kvalitet vazduha
(prekomerno zagađen vazduh) i blizina mesta gde deca provode značajan deo vremena.
Zdravstveni rizik je procenjen metodologijom koju preporučuje Američka agencija za zaštitu
životne sredine. Na osnovu vrednosti količnika hazarda (HQ) i indeksa hazarda (HI) rizik se
klasifikuje kao prihvatljiv (≤1) ili neprihvatljiv (>1) (2). HQ za PM10 čestice prelazi vrednost 1
u svim razmatranim područjima, ukazujući na neprihvatljiv rizik dok su vrednosti HI za
olovo manje od 1 ukazujući na prihvatljiv rizik u svim područjima. Dobijeni rezultati ukazuju
na potrebu preduzimanja mera u cilju smanjenja zagađenja vazduha u Republici Srbiji na
osnovu izračunatog zdravstvenog rizika od izloženosti suspendovanim česticama i olovu.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Assessment of children’s exposure to air pollutant PM10 and lead in crtitical districts in the Republic of Serbia, Procena izloženosti dece PM10 česticama i olovu putem zagađenog vazduha u kritičnim područjima Srbije",
volume = "72",
number = "4 suplement",
pages = "S601-S602",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4638"
}

Gladović, A., Petrović, B., Javorac, D., Buha-Đorđević, A., Ćurčić, M., Đukić-Ćosić, D., Šoštarić, A., Antonijević, B.,& Bulat, Z.. (2022). Assessment of children’s exposure to air pollutant PM10 and lead in crtitical districts in the Republic of Serbia. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S601-S602.
https://hdl.handle.net/21.15107/rcub_farfar_4638

Gladović A, Petrović B, Javorac D, Buha-Đorđević A, Ćurčić M, Đukić-Ćosić D, Šoštarić A, Antonijević B, Bulat Z. Assessment of children’s exposure to air pollutant PM10 and lead in crtitical districts in the Republic of Serbia. in Arhiv za farmaciju. 2022;72(4 suplement):S601-S602.
https://hdl.handle.net/21.15107/rcub_farfar_4638 .

Gladović, Ana, Petrović, Bojana, Javorac, Dragana, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Đukić-Ćosić, Danijela, Šoštarić, Andrej, Antonijević, Biljana, Bulat, Zorica, "Assessment of children’s exposure to air pollutant PM10 and lead in crtitical districts in the Republic of Serbia" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S601-S602,
https://hdl.handle.net/21.15107/rcub_farfar_4638 .

TY  - CONF
AU  - Atanacković, Milica
AU  - Baralić, Katarina
AU  - Ćurčić, Marijana
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Antonijević, Biljana
AU  - Bulat, Zorica
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4636
AB  - Opioids are a wide group of natural, semi-synthetic and synthetic substances, used in
the pharmacotherapy of painful conditions. However, due to their psychoactive properties,
they are often abused. Immunochromatographic test panels are used for substance abuse
monitoring and are quick, simple and based on the principle of competitive binding. Main
disadvantage of immunochromatographic analysis is cross-reactivity, because of sufficient
specificity of test antibodies for the analyte of interest. This study aimed to examine the
effect of codeine-based OTC preparation (Caffetin®) on false positive results of preliminary
opiate urineanalysis, and determine the time period during which these results may occur.
The study included two female healthy subjects, 23 and 24 years old. One of them
administered double oral dose of Caffetin® (two tablets - total of 20 mg of codeine) and the
other administred single oral dose of Caffetin® (one tablet - 10mg of codeine). Urine samples
were collected for 48h. Analysis was performed by AmeritekOPI® monocomponent test
strips and DOAMultiGnost 3 Test Panel® multicomponent test strips. The use of Caffetin®
gave false positive results for opiates after 4,7h (Subject 1) and 3,3 h (Subject 2). The first
negative result occurred after 39h (Subject 1) and 37,9h (Subject 2). After application of
codeine-based OTC preparations, false positive results were obtained in less than 48h.
Literature data indicate that positive results on opiates might occur 48h after consuming of
codeine-based medication. Hence, it is necessary to carry out further research with aim to
avoid doubts during interpretation of immunochromatographic test results.
AB  - Opioidi predstavljaju široku grupu supstanci prirodnog, polusintetskog i sintetskog
porekla, koje se osim primene u farmakoterapiji bolnih stanja, , često zloupotrebljavaju. Za
kontrolu zloupotrebe koriste se imunohromatografske test trake, brza i jednostavna analiza
zasnovana na principu kompetitivnog vezivanja. Glavni nedostatak im je pojava ukrštene
reaktivnosti usled niske specifičnosti antitela za analit od interesa. Cilj ovog rada je bio
ispitati uticaj primene OTC preparata koji sadrži kodein (Caffetin®) na pojavu lažno
pozitivnih rezultata preliminarne imunohromatografske analize opijata u urinu i utvrditi
vremenski period njihove pojave od trenutka primene analgetika. U istraživanju su
učestvovale dve zdrave ženske osobe starosti 23 i 24 godine. Jedna ispitanica je primenila
dozu koja sadrži 20 mg kodeina (2 tablete), a druga 10 mg kodeina (1 tableta). Uzorci urina
su sakupljani tokom narednih 48 h i analiza je vršena pomoću dve vrste
imunohromatografskih test traka: monokomponentnim AmeritekOPI ® i trokomponentnim
DOAMultiGnost 3 Test Panel® . Primenom Caffetin® tableta dobijeni su lažno pozitivni
rezultati na opijate prvi put nakon 4,7 h (Ispitanica 1) i 3,3 h (Ispitanica 2), a prvi negativan
rezultat se javio posle 39 h (Ispitanica 1) i 37,9 h (Ispitanica 2). Utvrđeno je da se nakon
primene OTC preparata sa kodeinom dobijaju lažno pozitivni rezultati na opijate u
vremenskom periodu kraćem od 48 h. Imajući u vidu da literaturni podaci ukazuju na to da
uzorak može biti pozitivan na opijate i do 48 h pri primeni kodeina, neophodno je sprovesti
detaljnija ispitivanja kako bi ova pojava u manjoj meri dovodila do nedoumica prilikom
tumačenju rezultata imunohromatografskih testova.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Time-dependent occurrence of false-positive results of opiate test strips after CAFFETIN® use
T1  - Vremenski zavisna pojava lažno pozitivnih rezultata test traka na opijate nakon primene leka CAFFETIN®
VL  - 72
IS  - 4 suplement
SP  - S599
EP  - S600
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4636
ER  - 

@conference{
author = "Atanacković, Milica and Baralić, Katarina and Ćurčić, Marijana and Javorac, Dragana and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Antonijević, Biljana and Bulat, Zorica and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "Opioids are a wide group of natural, semi-synthetic and synthetic substances, used in
the pharmacotherapy of painful conditions. However, due to their psychoactive properties,
they are often abused. Immunochromatographic test panels are used for substance abuse
monitoring and are quick, simple and based on the principle of competitive binding. Main
disadvantage of immunochromatographic analysis is cross-reactivity, because of sufficient
specificity of test antibodies for the analyte of interest. This study aimed to examine the
effect of codeine-based OTC preparation (Caffetin®) on false positive results of preliminary
opiate urineanalysis, and determine the time period during which these results may occur.
The study included two female healthy subjects, 23 and 24 years old. One of them
administered double oral dose of Caffetin® (two tablets - total of 20 mg of codeine) and the
other administred single oral dose of Caffetin® (one tablet - 10mg of codeine). Urine samples
were collected for 48h. Analysis was performed by AmeritekOPI® monocomponent test
strips and DOAMultiGnost 3 Test Panel® multicomponent test strips. The use of Caffetin®
gave false positive results for opiates after 4,7h (Subject 1) and 3,3 h (Subject 2). The first
negative result occurred after 39h (Subject 1) and 37,9h (Subject 2). After application of
codeine-based OTC preparations, false positive results were obtained in less than 48h.
Literature data indicate that positive results on opiates might occur 48h after consuming of
codeine-based medication. Hence, it is necessary to carry out further research with aim to
avoid doubts during interpretation of immunochromatographic test results., Opioidi predstavljaju široku grupu supstanci prirodnog, polusintetskog i sintetskog
porekla, koje se osim primene u farmakoterapiji bolnih stanja, , često zloupotrebljavaju. Za
kontrolu zloupotrebe koriste se imunohromatografske test trake, brza i jednostavna analiza
zasnovana na principu kompetitivnog vezivanja. Glavni nedostatak im je pojava ukrštene
reaktivnosti usled niske specifičnosti antitela za analit od interesa. Cilj ovog rada je bio
ispitati uticaj primene OTC preparata koji sadrži kodein (Caffetin®) na pojavu lažno
pozitivnih rezultata preliminarne imunohromatografske analize opijata u urinu i utvrditi
vremenski period njihove pojave od trenutka primene analgetika. U istraživanju su
učestvovale dve zdrave ženske osobe starosti 23 i 24 godine. Jedna ispitanica je primenila
dozu koja sadrži 20 mg kodeina (2 tablete), a druga 10 mg kodeina (1 tableta). Uzorci urina
su sakupljani tokom narednih 48 h i analiza je vršena pomoću dve vrste
imunohromatografskih test traka: monokomponentnim AmeritekOPI ® i trokomponentnim
DOAMultiGnost 3 Test Panel® . Primenom Caffetin® tableta dobijeni su lažno pozitivni
rezultati na opijate prvi put nakon 4,7 h (Ispitanica 1) i 3,3 h (Ispitanica 2), a prvi negativan
rezultat se javio posle 39 h (Ispitanica 1) i 37,9 h (Ispitanica 2). Utvrđeno je da se nakon
primene OTC preparata sa kodeinom dobijaju lažno pozitivni rezultati na opijate u
vremenskom periodu kraćem od 48 h. Imajući u vidu da literaturni podaci ukazuju na to da
uzorak može biti pozitivan na opijate i do 48 h pri primeni kodeina, neophodno je sprovesti
detaljnija ispitivanja kako bi ova pojava u manjoj meri dovodila do nedoumica prilikom
tumačenju rezultata imunohromatografskih testova.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Time-dependent occurrence of false-positive results of opiate test strips after CAFFETIN® use, Vremenski zavisna pojava lažno pozitivnih rezultata test traka na opijate nakon primene leka CAFFETIN®",
volume = "72",
number = "4 suplement",
pages = "S599-S600",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4636"
}

Atanacković, M., Baralić, K., Ćurčić, M., Javorac, D., Buha-Đorđević, A., Antonijević-Miljaković, E., Antonijević, B., Bulat, Z.,& Đukić-Ćosić, D.. (2022). Time-dependent occurrence of false-positive results of opiate test strips after CAFFETIN® use. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S599-S600.
https://hdl.handle.net/21.15107/rcub_farfar_4636

Atanacković M, Baralić K, Ćurčić M, Javorac D, Buha-Đorđević A, Antonijević-Miljaković E, Antonijević B, Bulat Z, Đukić-Ćosić D. Time-dependent occurrence of false-positive results of opiate test strips after CAFFETIN® use. in Arhiv za farmaciju. 2022;72(4 suplement):S599-S600.
https://hdl.handle.net/21.15107/rcub_farfar_4636 .

Atanacković, Milica, Baralić, Katarina, Ćurčić, Marijana, Javorac, Dragana, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Antonijević, Biljana, Bulat, Zorica, Đukić-Ćosić, Danijela, "Time-dependent occurrence of false-positive results of opiate test strips after CAFFETIN® use" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S599-S600,
https://hdl.handle.net/21.15107/rcub_farfar_4636 .

TY  - CONF
AU  - Kovačević, Milica
AU  - Baralić, Katarina
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Antonijević-Miljaković, Evica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4635
AB  - Acute poisonings by drugs used for cardiovascular diseases treatment are less
frequent than poisonings by other drugs, but often lead to serious disorders in various organ
systems and are characterized by relatively high mortality. When it comes to polydrug
poisoning by drugs with a depressant effect on the cardiovascular system, hospital care of
the patients is necessary. This research aimed to present data on acute poisonings by drugs
used in the cardiovascular diseases treatment in the Republic of Serbia in the period 2010-
2018 based on the published Annual reports of the National Poison Control Center of the
Military Medical Academy (1). Number of patients examined on suspicion of poisoning by
drugs for cardiovascular diseases treatment, in the period 2010-2018, ranged from 4-6% of
all examined due to acute drug poisoning per year, while number of hospitalizations due to
drug poisoning ranged from 7 to 11% of all hospitalized patients. Of the total number of
deaths resulting from drug poisoning, 27% are patients who died due to the poisoning by
drugs used for cardiovascular diseases treatment. The most common causes of poisoning in
the examined patients were beta blockers (45%), followed by Ca 2+ channel blockers (25%)
and ACE inhibitors (21%), and these three groups of drugs are the most common causes in
hospitalized patients as well. Lethal outcomes are most often the result of acute poisoning by
Ca 2+ channel blockers (50%) and beta blockers (40%), mainly in combination with drugs
used in psychiatric illnesses treatment, such as benzodiazepines, antiepileptics and
antipsychotics.
AB  - Akutna trovanja lekovima za lečenje kardiovaskularnih bolesti su ređa u odnosu na
trovanja drugim lekovima, ali često dovode do ozbiljnih poremećaja u funkcionisanju
različitih sistema organa i karakterišu se relativno visokim mortalitetom. Kada su u pitanju
polimedikamentozna trovanja lekovima koji imaju depresorno dejstvo na kardiovaskularni
sistem, neophodno je bolničko zbrinjavanje pacijenata. Cilj ovog rada je bio prikazati analizu
podataka o akutnim trovanjima lekovima koji se koriste u terapiji kardiovaskularnih
oboljenja u Republici Srbiji u periodu od 2010 do 2018. godine na osnovu publikovanih
Godišnjaka Nacionalanog centra za kontrolu trovanja Vojnomedicinske akademije (1). Broj
pacijenata koji su pregledani pod sumnjom na trovanje lekovima za lečenje
kardiovaskularnih bolesti u periodu 2010-2018. godine kretao se od 4-6% svih pacijenata
pregledanih usled akutnog trovanja lekovima godišnje, dok se broj pacijenata
hospitalizovanih usled trovanja lekovima kretao 7-11% svih hospitalizovanih pacijenata. Od
ukupnog broja letalnih ishoda koji su posledica trovanja lekovima, 27% čine pacijenti
preminuli zbog trovanja lekovima za lečenje kardiovaskularnih bolesti. Najčešći uzročnici
trovanja kod pregledanih pacijenata su beta blokatori (45%), zatim blokatori Ca 2+ kanala
(25%) i ACE inhibitori (21%), a ove tri grupe lekova su najzastupljenije i kod
hospitalizovanih pacijenata. Letalni ishodi su najčešće posledica akutnog trovanja
blokatorima Ca 2+ kanala (50%) i beta blokatorima (40%), uglavnom u kombinaciji sa
lekovima koji se koriste u terapiji psihijatrijskih oboljenja poput benzodiazepina,
antiepileptika i antipsihotika.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Acute poisonings by drugs used for the treatment of cardiovascular diseases in the Republic of Serbia
T1  - Akutna trovanja lekovima za terapiju kardiovaskularnih bolesti u Republici Srbiji
VL  - 72
IS  - 4 suplement
SP  - S597
EP  - S598
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4635
ER  - 

@conference{
author = "Kovačević, Milica and Baralić, Katarina and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Antonijević-Miljaković, Evica and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "Acute poisonings by drugs used for cardiovascular diseases treatment are less
frequent than poisonings by other drugs, but often lead to serious disorders in various organ
systems and are characterized by relatively high mortality. When it comes to polydrug
poisoning by drugs with a depressant effect on the cardiovascular system, hospital care of
the patients is necessary. This research aimed to present data on acute poisonings by drugs
used in the cardiovascular diseases treatment in the Republic of Serbia in the period 2010-
2018 based on the published Annual reports of the National Poison Control Center of the
Military Medical Academy (1). Number of patients examined on suspicion of poisoning by
drugs for cardiovascular diseases treatment, in the period 2010-2018, ranged from 4-6% of
all examined due to acute drug poisoning per year, while number of hospitalizations due to
drug poisoning ranged from 7 to 11% of all hospitalized patients. Of the total number of
deaths resulting from drug poisoning, 27% are patients who died due to the poisoning by
drugs used for cardiovascular diseases treatment. The most common causes of poisoning in
the examined patients were beta blockers (45%), followed by Ca 2+ channel blockers (25%)
and ACE inhibitors (21%), and these three groups of drugs are the most common causes in
hospitalized patients as well. Lethal outcomes are most often the result of acute poisoning by
Ca 2+ channel blockers (50%) and beta blockers (40%), mainly in combination with drugs
used in psychiatric illnesses treatment, such as benzodiazepines, antiepileptics and
antipsychotics., Akutna trovanja lekovima za lečenje kardiovaskularnih bolesti su ređa u odnosu na
trovanja drugim lekovima, ali često dovode do ozbiljnih poremećaja u funkcionisanju
različitih sistema organa i karakterišu se relativno visokim mortalitetom. Kada su u pitanju
polimedikamentozna trovanja lekovima koji imaju depresorno dejstvo na kardiovaskularni
sistem, neophodno je bolničko zbrinjavanje pacijenata. Cilj ovog rada je bio prikazati analizu
podataka o akutnim trovanjima lekovima koji se koriste u terapiji kardiovaskularnih
oboljenja u Republici Srbiji u periodu od 2010 do 2018. godine na osnovu publikovanih
Godišnjaka Nacionalanog centra za kontrolu trovanja Vojnomedicinske akademije (1). Broj
pacijenata koji su pregledani pod sumnjom na trovanje lekovima za lečenje
kardiovaskularnih bolesti u periodu 2010-2018. godine kretao se od 4-6% svih pacijenata
pregledanih usled akutnog trovanja lekovima godišnje, dok se broj pacijenata
hospitalizovanih usled trovanja lekovima kretao 7-11% svih hospitalizovanih pacijenata. Od
ukupnog broja letalnih ishoda koji su posledica trovanja lekovima, 27% čine pacijenti
preminuli zbog trovanja lekovima za lečenje kardiovaskularnih bolesti. Najčešći uzročnici
trovanja kod pregledanih pacijenata su beta blokatori (45%), zatim blokatori Ca 2+ kanala
(25%) i ACE inhibitori (21%), a ove tri grupe lekova su najzastupljenije i kod
hospitalizovanih pacijenata. Letalni ishodi su najčešće posledica akutnog trovanja
blokatorima Ca 2+ kanala (50%) i beta blokatorima (40%), uglavnom u kombinaciji sa
lekovima koji se koriste u terapiji psihijatrijskih oboljenja poput benzodiazepina,
antiepileptika i antipsihotika.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Acute poisonings by drugs used for the treatment of cardiovascular diseases in the Republic of Serbia, Akutna trovanja lekovima za terapiju kardiovaskularnih bolesti u Republici Srbiji",
volume = "72",
number = "4 suplement",
pages = "S597-S598",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4635"
}

Kovačević, M., Baralić, K., Buha-Đorđević, A., Ćurčić, M., Antonijević-Miljaković, E., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2022). Acute poisonings by drugs used for the treatment of cardiovascular diseases in the Republic of Serbia. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S597-S598.
https://hdl.handle.net/21.15107/rcub_farfar_4635

Kovačević M, Baralić K, Buha-Đorđević A, Ćurčić M, Antonijević-Miljaković E, Bulat Z, Antonijević B, Đukić-Ćosić D. Acute poisonings by drugs used for the treatment of cardiovascular diseases in the Republic of Serbia. in Arhiv za farmaciju. 2022;72(4 suplement):S597-S598.
https://hdl.handle.net/21.15107/rcub_farfar_4635 .

Kovačević, Milica, Baralić, Katarina, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Antonijević-Miljaković, Evica, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Acute poisonings by drugs used for the treatment of cardiovascular diseases in the Republic of Serbia" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S597-S598,
https://hdl.handle.net/21.15107/rcub_farfar_4635 .

TY  - CONF
AU  - Ćirić, Teodora
AU  - Baralić, Katarina
AU  - Marić, Đurđica
AU  - Javorac, Dragana
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4633
AB  - The aim of this investigation was to present data analysis on acute poisonings with
fatal outcome in the Republic of Serbia in from 2010 to 2018, based on the published Annual
reports of the National Poison Control Center of the Military Medical Academy (1). In the
observed 9-year period, the most common cause of acute poisoning was alcohol (50%),
followed by drugs (30.1%), while in the third and fourth place were psychoactive substances
(7.1%) and gases 4%. Corrosive and pesticide poisoning was present in only 2% of the total
number of examined patients per year. The most common reason for the hospitalization was
due to drug poisoning (71%), corrosives (9%), pesticides (5%), psychoactive substances
(4%), gases (4%) and other pathogens (7%). From 2010 to 2018, number of deaths due to
acute poisoning ranged from 26 to 43 annually with an average value of 33. Of 290 deceased
patients, 101 (34.9%) were of drug poisoning, 108 (38.5%) corrosives, 28 (9.8%) pesticides,
4 (1.4%) gases, 14 (4.6%) psychoactive substances and 37 (12.4%) other substances,
predominantly alcohols and mushrooms. Combination of two or more drugs most often led
to death (n=51), while among corrosives, hydrochloric acid was the most common (n=40). Of
the pesticides, the most common were organophosphorus insecticides (n=14), while heroin
was the most common psychoactive substance (n=7). The analyzed data indicated the
importance of preventive measures that need to be carried out in our country to reduce the
number of acute poisonings, especially the most severe forms that lead to death.
AB  - Cilj ovog rada bio je da se prikaže analiza podataka o akutnim trovanjima sa smrtnim
ishodom u Republici Srbiji u periodu od 2010. do 2018. godine na osnovu publikovanih
Godišnjaka Nacionalanog centra za kontrolu trovanja Vojnomedicinske akademije (1). U
posmatranom devetogodišnjem periodu najčešći uzročnik akutnih trovanja je alkohol (50%),
zatim lekovi (30,1%), dok su na trećem i četvrtom mestu psihoaktivne supstance (7,1%) i
gasovi 4%. Samo oko 2% od ukupnog broja pregledanih pacijenata godišnje su slučajevi
trovanja korozivima i pesticidima. Najčešći razlog hospitalizacije je usled trovanja lekovima
(71%), zatim korozivima (9%), pesticidima (5%), psihoaktivnim supstancama (4%),
gasovima (4%) i drugim uzročnicima (7%). Od 2010. do 2018. godine broj letalnih ishoda
usled akutnog trovanja se kretao od 26 do 43 slučaja godišnje sa prosečnom vrednošću od 33
slučaja po godini. Od 290 preminula pacijenta, 101 (34,9%) slučaj je bilo trovanje lekovima,
108 (38,5%) korozivima, 28 (9,8%) pesticidima, 4 (1,3%) gasovima, 14 (4,6%)
psihoaktivnim supstancama i 37 (12,4%) ostalim supstancama, dominantno alkoholima i
gljivama. Kombinacija dva i više lekova je najčešće dovela do smrtnog ishoda (n=51), dok je
među korozivima, najzastupljenija bila hlorovodonična kiselina (n=40). Od pesticida kao
uzročnika akutnih trovanja sa smrtnim ishodom najzastupljeniji su organofosforni
insekticidi (n=14), a prema broju smrtnih ishoda od psihoaktivnih supstanci najviše je
zastupljen heroin (n=7). Analizirani podaci ukazuju na značaj preventivnih aktivnosti koje je
u našoj zemlji potrebno sprovesti kako bi se smanjio broj akutnih trovanja, a time i onih
najtežih oblika koji dovode do smrtnog ishoda.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Causes of acute poisoning with a fatal outcome in the Republic of Serbia in the period from 2010 to 2018
T1  - Uzročnici akutnih trovanja sa smrtnim ishodom u Republici Srbiji u periodu od 2010. do 2018. godine
VL  - 72
IS  - 4 suplement
SP  - S593
EP  - S594
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4633
ER  - 

@conference{
author = "Ćirić, Teodora and Baralić, Katarina and Marić, Đurđica and Javorac, Dragana and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "The aim of this investigation was to present data analysis on acute poisonings with
fatal outcome in the Republic of Serbia in from 2010 to 2018, based on the published Annual
reports of the National Poison Control Center of the Military Medical Academy (1). In the
observed 9-year period, the most common cause of acute poisoning was alcohol (50%),
followed by drugs (30.1%), while in the third and fourth place were psychoactive substances
(7.1%) and gases 4%. Corrosive and pesticide poisoning was present in only 2% of the total
number of examined patients per year. The most common reason for the hospitalization was
due to drug poisoning (71%), corrosives (9%), pesticides (5%), psychoactive substances
(4%), gases (4%) and other pathogens (7%). From 2010 to 2018, number of deaths due to
acute poisoning ranged from 26 to 43 annually with an average value of 33. Of 290 deceased
patients, 101 (34.9%) were of drug poisoning, 108 (38.5%) corrosives, 28 (9.8%) pesticides,
4 (1.4%) gases, 14 (4.6%) psychoactive substances and 37 (12.4%) other substances,
predominantly alcohols and mushrooms. Combination of two or more drugs most often led
to death (n=51), while among corrosives, hydrochloric acid was the most common (n=40). Of
the pesticides, the most common were organophosphorus insecticides (n=14), while heroin
was the most common psychoactive substance (n=7). The analyzed data indicated the
importance of preventive measures that need to be carried out in our country to reduce the
number of acute poisonings, especially the most severe forms that lead to death., Cilj ovog rada bio je da se prikaže analiza podataka o akutnim trovanjima sa smrtnim
ishodom u Republici Srbiji u periodu od 2010. do 2018. godine na osnovu publikovanih
Godišnjaka Nacionalanog centra za kontrolu trovanja Vojnomedicinske akademije (1). U
posmatranom devetogodišnjem periodu najčešći uzročnik akutnih trovanja je alkohol (50%),
zatim lekovi (30,1%), dok su na trećem i četvrtom mestu psihoaktivne supstance (7,1%) i
gasovi 4%. Samo oko 2% od ukupnog broja pregledanih pacijenata godišnje su slučajevi
trovanja korozivima i pesticidima. Najčešći razlog hospitalizacije je usled trovanja lekovima
(71%), zatim korozivima (9%), pesticidima (5%), psihoaktivnim supstancama (4%),
gasovima (4%) i drugim uzročnicima (7%). Od 2010. do 2018. godine broj letalnih ishoda
usled akutnog trovanja se kretao od 26 do 43 slučaja godišnje sa prosečnom vrednošću od 33
slučaja po godini. Od 290 preminula pacijenta, 101 (34,9%) slučaj je bilo trovanje lekovima,
108 (38,5%) korozivima, 28 (9,8%) pesticidima, 4 (1,3%) gasovima, 14 (4,6%)
psihoaktivnim supstancama i 37 (12,4%) ostalim supstancama, dominantno alkoholima i
gljivama. Kombinacija dva i više lekova je najčešće dovela do smrtnog ishoda (n=51), dok je
među korozivima, najzastupljenija bila hlorovodonična kiselina (n=40). Od pesticida kao
uzročnika akutnih trovanja sa smrtnim ishodom najzastupljeniji su organofosforni
insekticidi (n=14), a prema broju smrtnih ishoda od psihoaktivnih supstanci najviše je
zastupljen heroin (n=7). Analizirani podaci ukazuju na značaj preventivnih aktivnosti koje je
u našoj zemlji potrebno sprovesti kako bi se smanjio broj akutnih trovanja, a time i onih
najtežih oblika koji dovode do smrtnog ishoda.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Causes of acute poisoning with a fatal outcome in the Republic of Serbia in the period from 2010 to 2018, Uzročnici akutnih trovanja sa smrtnim ishodom u Republici Srbiji u periodu od 2010. do 2018. godine",
volume = "72",
number = "4 suplement",
pages = "S593-S594",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4633"
}

Ćirić, T., Baralić, K., Marić, Đ., Javorac, D., Buha-Đorđević, A., Antonijević-Miljaković, E., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2022). Causes of acute poisoning with a fatal outcome in the Republic of Serbia in the period from 2010 to 2018. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S593-S594.
https://hdl.handle.net/21.15107/rcub_farfar_4633

Ćirić T, Baralić K, Marić Đ, Javorac D, Buha-Đorđević A, Antonijević-Miljaković E, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Causes of acute poisoning with a fatal outcome in the Republic of Serbia in the period from 2010 to 2018. in Arhiv za farmaciju. 2022;72(4 suplement):S593-S594.
https://hdl.handle.net/21.15107/rcub_farfar_4633 .

Ćirić, Teodora, Baralić, Katarina, Marić, Đurđica, Javorac, Dragana, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Causes of acute poisoning with a fatal outcome in the Republic of Serbia in the period from 2010 to 2018" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S593-S594,
https://hdl.handle.net/21.15107/rcub_farfar_4633 .

TY  - CONF
AU  - Živančević, Katarina
AU  - Baralić, Katarina
AU  - Božić, Dragica
AU  - Javorac, Dragana
AU  - Marić, Đurđica
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
AU  - Đukić-Ćosić, Danijela
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4632
AB  - Alternative form of cancer treatment includes targeting natural compounds such as
sulfur-rich dietary phytochemical sulforaphane (SFN). However, data on SFN safety,
interactions on the protein level and target of SFN in human organism are limited (1). The
aim of this study was to elucidate the target interactions of SFN in human body in order to
rationalize possible side-effects and predict off-targets by using in silico approach. STITCH
database (http://stitch.embl.de) was used to obtain the information about chemical–protein
interactions, while Metascape (https://metascape.org/) highlighted protein-protein
interaction enrichment (PPIE).
SwissTargetPrediction (http://www.swisstargetprediction.ch/) indicated the target
molecule classes of SFN in human. Human genes that had the strongest interaction with SFN
were NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1 and
GSTM1. PPIE analysis singled out fluid shear stress and atherosclerosis, NRF2 pathway and
chemical carcinogenesis - reactive oxygen species (ROS) as the most significant interactions.
The most represented class of SFN targeted molecules in human organism were enzymes
(26.7%). Epidermal growth factor receptor erbB1, macrophage migration inhibitory factor,
nitric oxide synthase (inducible) showed the highest probability target rate. In our previous
study (2), we pointed out that the genome of cancer patients could affect SFN safety. The
current study provides a set of target genes, emphasizes the importance of oxidative stress in
the suggested genetic interactions and predicts classes of target molecules, which should
further be examined.
AB  - Alternativni oblik lečenja raka uključuje upotrebu prirodnih jedinjenja kao što je
fitohemikalija bogata sumporom, sulforafan (SFN). Međutim, podaci o interakcijama SFN na
nivou proteina i ciljnih mesta dejstva SFN u ljudskom organizmu su ograničeni (1). Cilj ove
studije bio je da se ukaže na ciljne interakcije SFN kod ljudi kako bi se racionalizovali mogući
neželjeni efekti i predvidela nova ciljna mesta toksičnosti korišćenjem in silico pristupa.
STITCH baza podataka (http://stitch.embl.de) korišć ena je za dobijanje informacija o
interakcijama između hemikalija i proteina, dok je Metascape (https://metascape.org/)
izdvojio protein-protein interakcije (PPIE).
SwissTargetPrediction (http://vvv.svisstargetprediction.ch/) ukazao je na ciljana
mesta dejstva SFN kod ljudi. Izdvojeni su geni koji kod ljudi imaju najjaču interakciju sa SFN:
NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1, GSTM1.
Ateroskleroza, NRF2 signalni put i hemijska karcinogeneza - reaktivne vrste kiseonika (ROS)
označeni su kao najznačajnije protein-protein interakcije. Najzastupljenija klasa SFN ciljanih
molekula u ljudskom organizmu bili su enzimi (26,7%). Receptor epidermalnog faktora rasta
erbB1, faktor inhibitora migracije makrofaga i sintaza azot oksida (inducibilna) pokazali su
najveć u stopu verovatnoć e ciljnog mesta dejstva. U našoj prethodnoj studiji (2) istakli smo
da bi genom pacijenata obolelih od raka mogao uticati na bezbednost primene SFN. Međutim,
ova studija daje dodatni set ciljnih gena i naglašava važnost oksidativnog stresa u
predloženim interakcijama između gena, kao i predviđenim klasama ciljnih molekula na koje
deluje SFN i koje bi trebalo dalje ispitati.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes
T1  - Predviđanje štetnih efekata sulforafana in silico ispitivanjem njegovog ciljanog dejstva na gene, protein‐protein interakcije i klase molekula
VL  - 72
IS  - 4 suplement
SP  - S591
EP  - S592
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4632
ER  - 

@conference{
author = "Živančević, Katarina and Baralić, Katarina and Božić, Dragica and Javorac, Dragana and Marić, Đurđica and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana and Đukić-Ćosić, Danijela",
year = "2022",
abstract = "Alternative form of cancer treatment includes targeting natural compounds such as
sulfur-rich dietary phytochemical sulforaphane (SFN). However, data on SFN safety,
interactions on the protein level and target of SFN in human organism are limited (1). The
aim of this study was to elucidate the target interactions of SFN in human body in order to
rationalize possible side-effects and predict off-targets by using in silico approach. STITCH
database (http://stitch.embl.de) was used to obtain the information about chemical–protein
interactions, while Metascape (https://metascape.org/) highlighted protein-protein
interaction enrichment (PPIE).
SwissTargetPrediction (http://www.swisstargetprediction.ch/) indicated the target
molecule classes of SFN in human. Human genes that had the strongest interaction with SFN
were NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1 and
GSTM1. PPIE analysis singled out fluid shear stress and atherosclerosis, NRF2 pathway and
chemical carcinogenesis - reactive oxygen species (ROS) as the most significant interactions.
The most represented class of SFN targeted molecules in human organism were enzymes
(26.7%). Epidermal growth factor receptor erbB1, macrophage migration inhibitory factor,
nitric oxide synthase (inducible) showed the highest probability target rate. In our previous
study (2), we pointed out that the genome of cancer patients could affect SFN safety. The
current study provides a set of target genes, emphasizes the importance of oxidative stress in
the suggested genetic interactions and predicts classes of target molecules, which should
further be examined., Alternativni oblik lečenja raka uključuje upotrebu prirodnih jedinjenja kao što je
fitohemikalija bogata sumporom, sulforafan (SFN). Međutim, podaci o interakcijama SFN na
nivou proteina i ciljnih mesta dejstva SFN u ljudskom organizmu su ograničeni (1). Cilj ove
studije bio je da se ukaže na ciljne interakcije SFN kod ljudi kako bi se racionalizovali mogući
neželjeni efekti i predvidela nova ciljna mesta toksičnosti korišćenjem in silico pristupa.
STITCH baza podataka (http://stitch.embl.de) korišć ena je za dobijanje informacija o
interakcijama između hemikalija i proteina, dok je Metascape (https://metascape.org/)
izdvojio protein-protein interakcije (PPIE).
SwissTargetPrediction (http://vvv.svisstargetprediction.ch/) ukazao je na ciljana
mesta dejstva SFN kod ljudi. Izdvojeni su geni koji kod ljudi imaju najjaču interakciju sa SFN:
NQO1, NFE2L2, CASP3, HSP90AA1, MAPK14, HDAC6, HPGDS, KEAP1, GSTA1, GSTM1.
Ateroskleroza, NRF2 signalni put i hemijska karcinogeneza - reaktivne vrste kiseonika (ROS)
označeni su kao najznačajnije protein-protein interakcije. Najzastupljenija klasa SFN ciljanih
molekula u ljudskom organizmu bili su enzimi (26,7%). Receptor epidermalnog faktora rasta
erbB1, faktor inhibitora migracije makrofaga i sintaza azot oksida (inducibilna) pokazali su
najveć u stopu verovatnoć e ciljnog mesta dejstva. U našoj prethodnoj studiji (2) istakli smo
da bi genom pacijenata obolelih od raka mogao uticati na bezbednost primene SFN. Međutim,
ova studija daje dodatni set ciljnih gena i naglašava važnost oksidativnog stresa u
predloženim interakcijama između gena, kao i predviđenim klasama ciljnih molekula na koje
deluje SFN i koje bi trebalo dalje ispitati.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes, Predviđanje štetnih efekata sulforafana in silico ispitivanjem njegovog ciljanog dejstva na gene, protein‐protein interakcije i klase molekula",
volume = "72",
number = "4 suplement",
pages = "S591-S592",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4632"
}

Živančević, K., Baralić, K., Božić, D., Javorac, D., Marić, Đ., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z., Antonijević, B.,& Đukić-Ćosić, D.. (2022). Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S591-S592.
https://hdl.handle.net/21.15107/rcub_farfar_4632

Živančević K, Baralić K, Božić D, Javorac D, Marić Đ, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B, Đukić-Ćosić D. Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes. in Arhiv za farmaciju. 2022;72(4 suplement):S591-S592.
https://hdl.handle.net/21.15107/rcub_farfar_4632 .

Živančević, Katarina, Baralić, Katarina, Božić, Dragica, Javorac, Dragana, Marić, Đurđica, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, Đukić-Ćosić, Danijela, "Prediction of adverse effects of sulforaphane by in silico testing of targeted genes, protein- protein interactions and molecular classes" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S591-S592,
https://hdl.handle.net/21.15107/rcub_farfar_4632 .

TY  - CONF
AU  - Jorgovanović, Sonja
AU  - Božić, Dragica
AU  - Jorgovanović, Slaviša
AU  - Ćurčić, Marijana
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4628
AB  - The rapid global growth of drugs production and consumption undoubtedly leads to
contamination of the environment with pharmaceutical substances, as well as the products
of their decomposition and metabolism. Therefore, the ecosystem is exposed to
pharmaceutical waste, what may result in various unwanted effects, such as the
development of microorganism’s resistance to antibiotics. A brief review of the European
Union regulations, as well as the United States of America and Australia amadments,
revealed the diversity of approaches and regulatory measures adopted with the purpose of
proper hazardous waste handling. However, none of proposed systems show enviable
results. We conducted the research in the period of March-May 2020, to find out how citizens
of Bor municipality handle the pharmaceutical waste. A total of 226 responses were collected
by surveying patients, in person and in electronic form. The obtained results were analyzed
using the statistical software SPSS 21.0. The presented results show that the awareness of
the potential toxicity of pharmaceutical waste is developed in more than a third of
respondents (37.5%), but also low level of knowleadge about the proper way of disposing
generated waste. Over 36% of men and 42% of women throw away their medicines together
with other household waste, while 9% of men and 11% of women take them to pharmacies.
The legal regulations and accompanying guidelines, together with appropriate media
campaign, would contribute to a better understanding of the given problem and the adoption
of new citizens habits when it comes to hazardous waste handling.
AB  - Brz rast proizvodnje i potrošnje lekova na globalnom nivou, nesumnjivo dovodi do
kontaminacije životne sredine farmaceutskim supstancama, njihovim metabolitima, kao i
proizvodima njihove dodatne razgradnje u životnoj sredini. Posledično, živi svet biva izložen
uticaju farmaceutskog otpada usled čega dolazi do ispoljavanja različitih neželjenih efekata,
kao, na primer, razvoja rezistencije mikroorganizama na antibiotike. Kratkim pregledom
regulative zemalja članica Evropske unije, Sjedinjenih Američkih Država i Australije, uočena
je različitost pristupa i regulatornih mera donetih u cilju pravilnog rukovanja otpadom,
između ostalih i farmaceutskim otpadom, pri čemu ni jedan sistem ne pokazuje zavidne
rezultate. Istraživanjem rađenim u periodu mart-maj 2020. godine pokušali smo da dođemo
do saznanja koliko je razvijena svest građana opštine Bor, o postojanju farmaceutskog
otpada kao posebne kategorije koja može da ugrozi zdravlje ljudi ali i životnu sredinu.
Anketiranjem pacijenata, kako ličnim kontaktom, tako i u elektronskoj formi prikupljeno je
ukupno 226 odgovora, a dobijeni rezultati analizirani su pomoću statističkog softvera SPSS
21.0. Dobijeni rezultati pokazuju da je svest o štetnosti farmaceutskog otpada razvijena kod
više od trećine ispitanika (37,5%), ali i postojanje niskog stepena informisanosti o pravilnom
načinu zbrinjavanja generisanog otpada. Zbog toga, preko 36% muškaraca i 42% žena lekove
baca u komunalni otpad., dok ih 9% muškaraca i 11% žena odnosi u apoteke. Dopuna
zakonske regulative kao i pratećih pravilnika, propraćena odgovarajućom medijskom
kampanjom doprinela bi boljem razumevanju datog problema i usvajanju novih navika kod
građana u načinu rukovanja neiskorišćenim lekovima iz domaćinstva.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Awareness of the citizens from the municipality of Bor on the influence of pharmaceutical waste on human health and environment
T1  - Svest stanovništva opštine Bor o uticaju farmaceutskog otpada na zdravlje ljudi i životnu sredinu
VL  - 72
IS  - 4 suplement
SP  - S579
EP  - S580
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4628
ER  - 

@conference{
author = "Jorgovanović, Sonja and Božić, Dragica and Jorgovanović, Slaviša and Ćurčić, Marijana and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Javorac, Dragana and Baralić, Katarina and Bulat, Zorica and Antonijević, Biljana",
year = "2022",
abstract = "The rapid global growth of drugs production and consumption undoubtedly leads to
contamination of the environment with pharmaceutical substances, as well as the products
of their decomposition and metabolism. Therefore, the ecosystem is exposed to
pharmaceutical waste, what may result in various unwanted effects, such as the
development of microorganism’s resistance to antibiotics. A brief review of the European
Union regulations, as well as the United States of America and Australia amadments,
revealed the diversity of approaches and regulatory measures adopted with the purpose of
proper hazardous waste handling. However, none of proposed systems show enviable
results. We conducted the research in the period of March-May 2020, to find out how citizens
of Bor municipality handle the pharmaceutical waste. A total of 226 responses were collected
by surveying patients, in person and in electronic form. The obtained results were analyzed
using the statistical software SPSS 21.0. The presented results show that the awareness of
the potential toxicity of pharmaceutical waste is developed in more than a third of
respondents (37.5%), but also low level of knowleadge about the proper way of disposing
generated waste. Over 36% of men and 42% of women throw away their medicines together
with other household waste, while 9% of men and 11% of women take them to pharmacies.
The legal regulations and accompanying guidelines, together with appropriate media
campaign, would contribute to a better understanding of the given problem and the adoption
of new citizens habits when it comes to hazardous waste handling., Brz rast proizvodnje i potrošnje lekova na globalnom nivou, nesumnjivo dovodi do
kontaminacije životne sredine farmaceutskim supstancama, njihovim metabolitima, kao i
proizvodima njihove dodatne razgradnje u životnoj sredini. Posledično, živi svet biva izložen
uticaju farmaceutskog otpada usled čega dolazi do ispoljavanja različitih neželjenih efekata,
kao, na primer, razvoja rezistencije mikroorganizama na antibiotike. Kratkim pregledom
regulative zemalja članica Evropske unije, Sjedinjenih Američkih Država i Australije, uočena
je različitost pristupa i regulatornih mera donetih u cilju pravilnog rukovanja otpadom,
između ostalih i farmaceutskim otpadom, pri čemu ni jedan sistem ne pokazuje zavidne
rezultate. Istraživanjem rađenim u periodu mart-maj 2020. godine pokušali smo da dođemo
do saznanja koliko je razvijena svest građana opštine Bor, o postojanju farmaceutskog
otpada kao posebne kategorije koja može da ugrozi zdravlje ljudi ali i životnu sredinu.
Anketiranjem pacijenata, kako ličnim kontaktom, tako i u elektronskoj formi prikupljeno je
ukupno 226 odgovora, a dobijeni rezultati analizirani su pomoću statističkog softvera SPSS
21.0. Dobijeni rezultati pokazuju da je svest o štetnosti farmaceutskog otpada razvijena kod
više od trećine ispitanika (37,5%), ali i postojanje niskog stepena informisanosti o pravilnom
načinu zbrinjavanja generisanog otpada. Zbog toga, preko 36% muškaraca i 42% žena lekove
baca u komunalni otpad., dok ih 9% muškaraca i 11% žena odnosi u apoteke. Dopuna
zakonske regulative kao i pratećih pravilnika, propraćena odgovarajućom medijskom
kampanjom doprinela bi boljem razumevanju datog problema i usvajanju novih navika kod
građana u načinu rukovanja neiskorišćenim lekovima iz domaćinstva.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Awareness of the citizens from the municipality of Bor on the influence of pharmaceutical waste on human health and environment, Svest stanovništva opštine Bor o uticaju farmaceutskog otpada na zdravlje ljudi i životnu sredinu",
volume = "72",
number = "4 suplement",
pages = "S579-S580",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4628"
}

Jorgovanović, S., Božić, D., Jorgovanović, S., Ćurčić, M., Buha-Đorđević, A., Antonijević-Miljaković, E., Đukić-Ćosić, D., Javorac, D., Baralić, K., Bulat, Z.,& Antonijević, B.. (2022). Awareness of the citizens from the municipality of Bor on the influence of pharmaceutical waste on human health and environment. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S579-S580.
https://hdl.handle.net/21.15107/rcub_farfar_4628

Jorgovanović S, Božić D, Jorgovanović S, Ćurčić M, Buha-Đorđević A, Antonijević-Miljaković E, Đukić-Ćosić D, Javorac D, Baralić K, Bulat Z, Antonijević B. Awareness of the citizens from the municipality of Bor on the influence of pharmaceutical waste on human health and environment. in Arhiv za farmaciju. 2022;72(4 suplement):S579-S580.
https://hdl.handle.net/21.15107/rcub_farfar_4628 .

Jorgovanović, Sonja, Božić, Dragica, Jorgovanović, Slaviša, Ćurčić, Marijana, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Javorac, Dragana, Baralić, Katarina, Bulat, Zorica, Antonijević, Biljana, "Awareness of the citizens from the municipality of Bor on the influence of pharmaceutical waste on human health and environment" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S579-S580,
https://hdl.handle.net/21.15107/rcub_farfar_4628 .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Ćatović, Rialda
AU  - Ćirović, Tatjana
AU  - Stojilković, Nikola
AU  - Buha-Đorđević, Aleksandra
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4627
AB  - The aim of this study was to evaluate the awareness of livestock breeders on the used
veterinary drugs in order to assess potential environmental contamination in the region of
Sjenica. Veterinary drugs can enter the environment mostly due to widespread usage, but
also as metabolites eliminated from the organisms. In order to evaluate the awareness of
livestock breeders, a survey questionnaire was used. Questions were related to the most
frequently used veterinary drugs without the supervision of a veterinary medical doctor. The
obtained data show that the awareness of domestic animal breeders on the use of veterinary
drugs is very low in the region of Sjenica. The most commonly used veterinary medicines
were antibiotics, streptomycin, and benzylpenicillin-procaine, antihelmintic, albendazole.
Unexpectedly, the animal breeders identified formaldehyde as veterinary medicine and used
it as a disinfectant in poultry raising. The results also show that breeders frequently treat
animals with drugs on their own, without control by veterinary medical doctors. Because of
the wide use of veterinary medicines in the region of Sjenica, it monitoring of the
environmental concentration of streptomycin, benzylpenicillin-procaine, and albendazole, as
well as metabolites in soil and water should be recommended. Moreover, human exposure to
these veterinary medicines could occur because of the abuse of veterinary medicines, no
consultations with veterinary medical doctors, and non-proper handling of waste from
animals.
AB  - Veterinarski lekovi dospevaju u životnu sredinu najčešće usled neadekvatnog
odlaganja otpada, ali i kao metaboliti iz organizma životinja. Cilj studije je bio procena nivoa
svesti uzgajivača stoke o upotrebi veterinarskih lekova u regionu Sjenice sa ciljem procene
potencijalne kontaminacije životne sredine. Za procenu nivoa svesti uzgajivača stoke
korišćen je anketni upitnik. Pitanja iz upitnika su se odnosila na najčešće korišćene
veterinarske lekove i korišćenje bez nadzora veterinara. Dobijeni podaci pokazuju da je nivo
svestu uzgajivača stoke u regionu Sjenice nizak jer koriste veterinarske lekove bez nadzora
veterinara. Najčešće koriste antibiotike, streptomicin i benzoil-penicilin, antihelmintik –
abendazol i, iznenađujuće, koriste formaldehid za dezinfekciju prostorija za smeštaj
životinja, pri čemu ga smatraju veterinarskim lekom. Zbog rasprostranjene upoutrebe
veterinarskih lekova u regionu Sjenice od strane uzgajivača stoke, a bez kontrole veterinara
preporučuje se monitoring streptomicina, benzoilpenicilina i abendazola kao i njihovih
metabolita u životnoj sredini, zemljištu i vodi. Potrebno je preduzeti dodatne mere opreza da
zbog niskog nivoa svesti ne bi došlo do izloženosti ljudi ovim veterinarskim lekovima i
njihovim metabolitima naročito zbog neadekvatnog tretiranja stajnjaka i drugog otpada.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Awareness on the use of veterinary drugs in the region of Sjenica as potential environmental pollutants
T1  - Svest o korišćenju veterinarskih lekova u regionu Sjenice kao potencijalnih zagađivača životne sredine
VL  - 72
IS  - 4 suplement
SP  - S577
EP  - S578
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4627
ER  - 

@conference{
author = "Ćurčić, Marijana and Ćatović, Rialda and Ćirović, Tatjana and Stojilković, Nikola and Buha-Đorđević, Aleksandra and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Javorac, Dragana and Baralić, Katarina and Bulat, Zorica and Antonijević, Biljana",
year = "2022",
abstract = "The aim of this study was to evaluate the awareness of livestock breeders on the used
veterinary drugs in order to assess potential environmental contamination in the region of
Sjenica. Veterinary drugs can enter the environment mostly due to widespread usage, but
also as metabolites eliminated from the organisms. In order to evaluate the awareness of
livestock breeders, a survey questionnaire was used. Questions were related to the most
frequently used veterinary drugs without the supervision of a veterinary medical doctor. The
obtained data show that the awareness of domestic animal breeders on the use of veterinary
drugs is very low in the region of Sjenica. The most commonly used veterinary medicines
were antibiotics, streptomycin, and benzylpenicillin-procaine, antihelmintic, albendazole.
Unexpectedly, the animal breeders identified formaldehyde as veterinary medicine and used
it as a disinfectant in poultry raising. The results also show that breeders frequently treat
animals with drugs on their own, without control by veterinary medical doctors. Because of
the wide use of veterinary medicines in the region of Sjenica, it monitoring of the
environmental concentration of streptomycin, benzylpenicillin-procaine, and albendazole, as
well as metabolites in soil and water should be recommended. Moreover, human exposure to
these veterinary medicines could occur because of the abuse of veterinary medicines, no
consultations with veterinary medical doctors, and non-proper handling of waste from
animals., Veterinarski lekovi dospevaju u životnu sredinu najčešće usled neadekvatnog
odlaganja otpada, ali i kao metaboliti iz organizma životinja. Cilj studije je bio procena nivoa
svesti uzgajivača stoke o upotrebi veterinarskih lekova u regionu Sjenice sa ciljem procene
potencijalne kontaminacije životne sredine. Za procenu nivoa svesti uzgajivača stoke
korišćen je anketni upitnik. Pitanja iz upitnika su se odnosila na najčešće korišćene
veterinarske lekove i korišćenje bez nadzora veterinara. Dobijeni podaci pokazuju da je nivo
svestu uzgajivača stoke u regionu Sjenice nizak jer koriste veterinarske lekove bez nadzora
veterinara. Najčešće koriste antibiotike, streptomicin i benzoil-penicilin, antihelmintik –
abendazol i, iznenađujuće, koriste formaldehid za dezinfekciju prostorija za smeštaj
životinja, pri čemu ga smatraju veterinarskim lekom. Zbog rasprostranjene upoutrebe
veterinarskih lekova u regionu Sjenice od strane uzgajivača stoke, a bez kontrole veterinara
preporučuje se monitoring streptomicina, benzoilpenicilina i abendazola kao i njihovih
metabolita u životnoj sredini, zemljištu i vodi. Potrebno je preduzeti dodatne mere opreza da
zbog niskog nivoa svesti ne bi došlo do izloženosti ljudi ovim veterinarskim lekovima i
njihovim metabolitima naročito zbog neadekvatnog tretiranja stajnjaka i drugog otpada.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Awareness on the use of veterinary drugs in the region of Sjenica as potential environmental pollutants, Svest o korišćenju veterinarskih lekova u regionu Sjenice kao potencijalnih zagađivača životne sredine",
volume = "72",
number = "4 suplement",
pages = "S577-S578",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4627"
}

Ćurčić, M., Ćatović, R., Ćirović, T., Stojilković, N., Buha-Đorđević, A., Antonijević-Miljaković, E., Đukić-Ćosić, D., Javorac, D., Baralić, K., Bulat, Z.,& Antonijević, B.. (2022). Awareness on the use of veterinary drugs in the region of Sjenica as potential environmental pollutants. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S577-S578.
https://hdl.handle.net/21.15107/rcub_farfar_4627

Ćurčić M, Ćatović R, Ćirović T, Stojilković N, Buha-Đorđević A, Antonijević-Miljaković E, Đukić-Ćosić D, Javorac D, Baralić K, Bulat Z, Antonijević B. Awareness on the use of veterinary drugs in the region of Sjenica as potential environmental pollutants. in Arhiv za farmaciju. 2022;72(4 suplement):S577-S578.
https://hdl.handle.net/21.15107/rcub_farfar_4627 .

Ćurčić, Marijana, Ćatović, Rialda, Ćirović, Tatjana, Stojilković, Nikola, Buha-Đorđević, Aleksandra, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Javorac, Dragana, Baralić, Katarina, Bulat, Zorica, Antonijević, Biljana, "Awareness on the use of veterinary drugs in the region of Sjenica as potential environmental pollutants" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S577-S578,
https://hdl.handle.net/21.15107/rcub_farfar_4627 .

TY  - CONF
AU  - Ćurčić, Marijana
AU  - Janković, Saša
AU  - Buha-Đorđević, Aleksandra
AU  - Milovanović, Vesna
AU  - Antonijević-Miljaković, Evica
AU  - Đukić-Ćosić, Danijela
AU  - Javorac, Dragana
AU  - Baralić, Katarina
AU  - Živančević, Katarina
AU  - Božić, Dragica
AU  - Durgo, Ksenija
AU  - Vučinić, Slavica
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4626
AB  - Humans are exposed to the chemicals from very different sources. Therefore, the
exposure assessment should be focused on mixtures rather than single chemicals. In this
study, bioelements (Zn and Cu) homeostasis effects of mixture of Cd and BDE-209, widely
spread persistent environmental pollutants, has been evaluated. In order to evaluate the
potential of mixture on Zn and Cu homeosthasis in rats kidneys, Wistar rats were treated by
oral gavage during 28 days with three doses of Cd 2.5, 7.5, and 15 mg/bw/day, three
combinations of Cd with 1000 mg BDE-209/kg/day, and water as a control group. Kidney
tissue samples were collected, mineralised, and Cu and Zn levels were measured by flame
atomic absorbtion spectrophotometer. Possible interactions were evaluated comparing the
dose-response curves slopes and lower confidence limit of Benchmark dose of 10%
(BMDL10) were calculated by PROAST software (RIVM, Netherlands). Cd alone can disturb
Zn in kidneys and calculated BMDL10 was 1.713 mg Cd/kg/day, while in combination with
BDE-209 it was 1.719 mg/kg/day. Cd disturbs Cu in kidney in significantly higher dose of
5.679 mg Cd/kg/day. However, in combination with the BDE-209, derived BMDL10 was 10
times lower, 0.517 mg Cd/kg/day. Dose-response curve slope for the effect on Cu was
significantly lower in the case of mixture effect than in the case of Cd effect. Since Cu plays a
major role in the blood cells creation and health of other systems, our results indicate more
potent activity of the mixture than single Cd.
AB  - Ljudi mogu biti izloženi hemikalijama iz različitih izvora, te je potrebno procenjivati
efekte na bazi izloženosti smešama hemikalija, pre nego pojedinačnim hemikalijama. U
studiji je analiziran uticaj smeše Cd i BDE-209, široko rasprostranjenih zagađujućih
perzistentnih supstanci, na homeostazu bioelemenata, cinka (Zn) i bakra (Cu). U cilju
evaluacije potencijala smeše da naruši homeostazu Zn i Cu u bubrezima pacova, Wistar
pacovi su oralnom gavažom bili tretirani tokom 28 dana dozama Cd od 2,5, 7,5 i 15
mg/kg/dan, kombinacijama ove tri doze sa 1000 mg BDE-209/kg/dan i vodom kao
kontrolom. Tkivo bubrega je izdvojeno, zatim mineralizovano, a sadržaj Zn i Cu je meren
atomskom apsorpcionom spektrofotometrijom. Moguće interakcije su procenjivane
poređenjem nagiba krivih doza-odgovor, a izračunate su i donje granice pouzdanosti
Benchmark doze od 10% (BMDL10) korišćenjem PROAST softvera (RIVM, Holandija). Cd
primenjen sam utiče na homeostazu Zn u bubregu i izračunata BMDL10 iznosi 1,713
mg/kg/dan, dok u kombinacji sa BDE-209 iznosi 1,719 mg/kg/dan. Cd ometa homeostazu Cu
u bubregu pacova i BMDL10 iznosi 5,679 mg/kg/dan, dok je u kombinaciji sa BDE-209 BMDL
10 puta niža i iznosi 0,517 mg/kg/dan. Nagib krive doza odgovor za smešu Cd i BDE-209 bio
je daleko niži od nagiba krive doza-odgovor za Cd. S obzirom na to da Cu igra značajnu ulogu
u nastanku krvnih ćelija, ali i u očuvanju durgih sistema organa, dobijeni rezultati iziskuju
pažnju zbog daleko potentnijeg uticaja smeše na nivo Cu u odnosu na uticaj samog Cd.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats
T1  - Uticaj smeše Cd i BDE‐209 na homeostazu Zn i Cu u bubregu pacova
VL  - 72
IS  - 4 suplement
SP  - S575
EP  - S576
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4626
ER  - 

@conference{
author = "Ćurčić, Marijana and Janković, Saša and Buha-Đorđević, Aleksandra and Milovanović, Vesna and Antonijević-Miljaković, Evica and Đukić-Ćosić, Danijela and Javorac, Dragana and Baralić, Katarina and Živančević, Katarina and Božić, Dragica and Durgo, Ksenija and Vučinić, Slavica and Bulat, Zorica and Antonijević, Biljana",
year = "2022",
abstract = "Humans are exposed to the chemicals from very different sources. Therefore, the
exposure assessment should be focused on mixtures rather than single chemicals. In this
study, bioelements (Zn and Cu) homeostasis effects of mixture of Cd and BDE-209, widely
spread persistent environmental pollutants, has been evaluated. In order to evaluate the
potential of mixture on Zn and Cu homeosthasis in rats kidneys, Wistar rats were treated by
oral gavage during 28 days with three doses of Cd 2.5, 7.5, and 15 mg/bw/day, three
combinations of Cd with 1000 mg BDE-209/kg/day, and water as a control group. Kidney
tissue samples were collected, mineralised, and Cu and Zn levels were measured by flame
atomic absorbtion spectrophotometer. Possible interactions were evaluated comparing the
dose-response curves slopes and lower confidence limit of Benchmark dose of 10%
(BMDL10) were calculated by PROAST software (RIVM, Netherlands). Cd alone can disturb
Zn in kidneys and calculated BMDL10 was 1.713 mg Cd/kg/day, while in combination with
BDE-209 it was 1.719 mg/kg/day. Cd disturbs Cu in kidney in significantly higher dose of
5.679 mg Cd/kg/day. However, in combination with the BDE-209, derived BMDL10 was 10
times lower, 0.517 mg Cd/kg/day. Dose-response curve slope for the effect on Cu was
significantly lower in the case of mixture effect than in the case of Cd effect. Since Cu plays a
major role in the blood cells creation and health of other systems, our results indicate more
potent activity of the mixture than single Cd., Ljudi mogu biti izloženi hemikalijama iz različitih izvora, te je potrebno procenjivati
efekte na bazi izloženosti smešama hemikalija, pre nego pojedinačnim hemikalijama. U
studiji je analiziran uticaj smeše Cd i BDE-209, široko rasprostranjenih zagađujućih
perzistentnih supstanci, na homeostazu bioelemenata, cinka (Zn) i bakra (Cu). U cilju
evaluacije potencijala smeše da naruši homeostazu Zn i Cu u bubrezima pacova, Wistar
pacovi su oralnom gavažom bili tretirani tokom 28 dana dozama Cd od 2,5, 7,5 i 15
mg/kg/dan, kombinacijama ove tri doze sa 1000 mg BDE-209/kg/dan i vodom kao
kontrolom. Tkivo bubrega je izdvojeno, zatim mineralizovano, a sadržaj Zn i Cu je meren
atomskom apsorpcionom spektrofotometrijom. Moguće interakcije su procenjivane
poređenjem nagiba krivih doza-odgovor, a izračunate su i donje granice pouzdanosti
Benchmark doze od 10% (BMDL10) korišćenjem PROAST softvera (RIVM, Holandija). Cd
primenjen sam utiče na homeostazu Zn u bubregu i izračunata BMDL10 iznosi 1,713
mg/kg/dan, dok u kombinacji sa BDE-209 iznosi 1,719 mg/kg/dan. Cd ometa homeostazu Cu
u bubregu pacova i BMDL10 iznosi 5,679 mg/kg/dan, dok je u kombinaciji sa BDE-209 BMDL
10 puta niža i iznosi 0,517 mg/kg/dan. Nagib krive doza odgovor za smešu Cd i BDE-209 bio
je daleko niži od nagiba krive doza-odgovor za Cd. S obzirom na to da Cu igra značajnu ulogu
u nastanku krvnih ćelija, ali i u očuvanju durgih sistema organa, dobijeni rezultati iziskuju
pažnju zbog daleko potentnijeg uticaja smeše na nivo Cu u odnosu na uticaj samog Cd.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats, Uticaj smeše Cd i BDE‐209 na homeostazu Zn i Cu u bubregu pacova",
volume = "72",
number = "4 suplement",
pages = "S575-S576",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4626"
}

Ćurčić, M., Janković, S., Buha-Đorđević, A., Milovanović, V., Antonijević-Miljaković, E., Đukić-Ćosić, D., Javorac, D., Baralić, K., Živančević, K., Božić, D., Durgo, K., Vučinić, S., Bulat, Z.,& Antonijević, B.. (2022). Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S575-S576.
https://hdl.handle.net/21.15107/rcub_farfar_4626

Ćurčić M, Janković S, Buha-Đorđević A, Milovanović V, Antonijević-Miljaković E, Đukić-Ćosić D, Javorac D, Baralić K, Živančević K, Božić D, Durgo K, Vučinić S, Bulat Z, Antonijević B. Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats. in Arhiv za farmaciju. 2022;72(4 suplement):S575-S576.
https://hdl.handle.net/21.15107/rcub_farfar_4626 .

Ćurčić, Marijana, Janković, Saša, Buha-Đorđević, Aleksandra, Milovanović, Vesna, Antonijević-Miljaković, Evica, Đukić-Ćosić, Danijela, Javorac, Dragana, Baralić, Katarina, Živančević, Katarina, Božić, Dragica, Durgo, Ksenija, Vučinić, Slavica, Bulat, Zorica, Antonijević, Biljana, "Influence of the mixture of Cd and BDE-209 on Zn and Cu homeostasis in rats" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S575-S576,
https://hdl.handle.net/21.15107/rcub_farfar_4626 .

TY  - CONF
AU  - Umićević, Nina
AU  - Baralić, Katarina
AU  - Đukić-Ćosić, Danijela
AU  - Antonijević-Miljaković, Evica
AU  - Buha-Đorđević, Aleksandra
AU  - Ćurčić, Marijana
AU  - Bulat, Zorica
AU  - Antonijević, Biljana
PY  - 2022
UR  - https://farfar.pharmacy.bg.ac.rs/handle/123456789/4608
AB  - Organic solvents are still widely used in various industries and considered the most
common chemicals associated with liver injury in workers. For research into the
relationships between these chemicals and genes, interactions among chemicals, molecular
pathways and biological processes, a significant place in toxicity testing has been taken by in
silico methodologies. This study aims to provide evidence for the involvement of a selected
mixture of organic solvents (toluene, styrene, ethanol) in liver disease development and
show the potential of in silico toxicogenomic data-mining in determining possible
mechanisms of mixture toxicity. The Comparative Toxicogenomics Database (CTD),
GeneMania and ToppGene Suite were used for data-mining. The results showed that there
were 17 genes connected with liver injury common for all the tested solvents. Co-expression
(61.73%) was the most prominent interaction between the genes, while physical
interactions were present at 14.56%, co-localization at 12.54% and interactions predicted by
the server at 6.62%. Gene ontology analysis revealed biological processes affected by the
investigated mixture (reactive oxygen species metabolic and biosynthetic process, response
to oxidative stress, and response to organic cyclic compound). Oxidative stress response,
antioxidant and oxidoreductase activity, vitamin B12 metabolism were noted as the key
molecular pathways contributing to liver disease development. Our results emphasize the
role of oxidative stress as one of the mechanisms of organic solvents' mixture toxicity and
provide new insights into molecular mechanisms involved in hepatotoxicity.
AB  - Organski rastvarači se još uvek široko koriste u raznim industrijama i smatraju se
najčešćim hemikalijama povezanim sa oštećenjem jetre kod radnika. Za istraživanje odnosa
između ovih hemikalija i gena, interakcija među hemikalijama, molekularnih puteva i
bioloških procesa, značajno mjesto pripada i in silico metodologijama. Cilj ove studije je da
pruži dokaze za povezanost odabrane smeše organskih rastvarača (toluen, stiren, etanol) u
razvoju bolesti jetre, i da pokaže potencijal in silico toksikogenomičke analize podataka u
određivanju mogućih mehanizama toksičnosti smješe. Za prikupljanje podataka korišteni su
Comparative Toxicogenomics Database (CTD), GeneMania i ToppGene Suite. Rezultati ove
analize su pokazali da postoji 17 gena povezanih s oštećenjem jetre zajedničkih za sva tri
navedena rastvarača. Koekspresija (61,73%) bila je najistaknutija interakcija između gena,
dok su fizičke interakcije bile prisutne sa 14,56%, kolokalizacije sa 12,54%, a interakcije
predviđene od strane servera sa 6,62%. Analiza ontologije gena izdvojila je biološke procese
na koje utiče ispitivana smeša (metabolički i biosintetski proces reaktivnih kiseonikovih
vrsta, odgovor na oksidativni stres i odgovor na organska ciklična jedinjenja). Odgovor na
oksidativni stres, aktivnost antioksidanata i oksidoreduktaze, i metabolizam vitamina B12 su
navedeni kao ključni molekularni putevi koji dobrinose razvoju bolesti jetre. Rezultati ovog
rada naglašavaju ulogu oksidativnog stresa kao jednog od mehanizama toksičnosti smeše
organskih rastvarača i daju novi uvid u molekularne mehanizme uključene u
hepatotoksičnost.
PB  - Savez farmaceutskih udruženja Srbije (SFUS)
C3  - Arhiv za farmaciju
T1  - The hepatotoxic potential of a mixture of toluene, styrene and ethanol: in silico toxicogenomic data-mining
T1  - Hepatotoksični potencijal smeše toluena, stirena i etanola: in silico toksikogenomička analiza
VL  - 72
IS  - 4 suplement
SP  - S567
EP  - S568
UR  - https://hdl.handle.net/21.15107/rcub_farfar_4608
ER  - 

@conference{
author = "Umićević, Nina and Baralić, Katarina and Đukić-Ćosić, Danijela and Antonijević-Miljaković, Evica and Buha-Đorđević, Aleksandra and Ćurčić, Marijana and Bulat, Zorica and Antonijević, Biljana",
year = "2022",
abstract = "Organic solvents are still widely used in various industries and considered the most
common chemicals associated with liver injury in workers. For research into the
relationships between these chemicals and genes, interactions among chemicals, molecular
pathways and biological processes, a significant place in toxicity testing has been taken by in
silico methodologies. This study aims to provide evidence for the involvement of a selected
mixture of organic solvents (toluene, styrene, ethanol) in liver disease development and
show the potential of in silico toxicogenomic data-mining in determining possible
mechanisms of mixture toxicity. The Comparative Toxicogenomics Database (CTD),
GeneMania and ToppGene Suite were used for data-mining. The results showed that there
were 17 genes connected with liver injury common for all the tested solvents. Co-expression
(61.73%) was the most prominent interaction between the genes, while physical
interactions were present at 14.56%, co-localization at 12.54% and interactions predicted by
the server at 6.62%. Gene ontology analysis revealed biological processes affected by the
investigated mixture (reactive oxygen species metabolic and biosynthetic process, response
to oxidative stress, and response to organic cyclic compound). Oxidative stress response,
antioxidant and oxidoreductase activity, vitamin B12 metabolism were noted as the key
molecular pathways contributing to liver disease development. Our results emphasize the
role of oxidative stress as one of the mechanisms of organic solvents' mixture toxicity and
provide new insights into molecular mechanisms involved in hepatotoxicity., Organski rastvarači se još uvek široko koriste u raznim industrijama i smatraju se
najčešćim hemikalijama povezanim sa oštećenjem jetre kod radnika. Za istraživanje odnosa
između ovih hemikalija i gena, interakcija među hemikalijama, molekularnih puteva i
bioloških procesa, značajno mjesto pripada i in silico metodologijama. Cilj ove studije je da
pruži dokaze za povezanost odabrane smeše organskih rastvarača (toluen, stiren, etanol) u
razvoju bolesti jetre, i da pokaže potencijal in silico toksikogenomičke analize podataka u
određivanju mogućih mehanizama toksičnosti smješe. Za prikupljanje podataka korišteni su
Comparative Toxicogenomics Database (CTD), GeneMania i ToppGene Suite. Rezultati ove
analize su pokazali da postoji 17 gena povezanih s oštećenjem jetre zajedničkih za sva tri
navedena rastvarača. Koekspresija (61,73%) bila je najistaknutija interakcija između gena,
dok su fizičke interakcije bile prisutne sa 14,56%, kolokalizacije sa 12,54%, a interakcije
predviđene od strane servera sa 6,62%. Analiza ontologije gena izdvojila je biološke procese
na koje utiče ispitivana smeša (metabolički i biosintetski proces reaktivnih kiseonikovih
vrsta, odgovor na oksidativni stres i odgovor na organska ciklična jedinjenja). Odgovor na
oksidativni stres, aktivnost antioksidanata i oksidoreduktaze, i metabolizam vitamina B12 su
navedeni kao ključni molekularni putevi koji dobrinose razvoju bolesti jetre. Rezultati ovog
rada naglašavaju ulogu oksidativnog stresa kao jednog od mehanizama toksičnosti smeše
organskih rastvarača i daju novi uvid u molekularne mehanizme uključene u
hepatotoksičnost.",
publisher = "Savez farmaceutskih udruženja Srbije (SFUS)",
journal = "Arhiv za farmaciju",
title = "The hepatotoxic potential of a mixture of toluene, styrene and ethanol: in silico toxicogenomic data-mining, Hepatotoksični potencijal smeše toluena, stirena i etanola: in silico toksikogenomička analiza",
volume = "72",
number = "4 suplement",
pages = "S567-S568",
url = "https://hdl.handle.net/21.15107/rcub_farfar_4608"
}

Umićević, N., Baralić, K., Đukić-Ćosić, D., Antonijević-Miljaković, E., Buha-Đorđević, A., Ćurčić, M., Bulat, Z.,& Antonijević, B.. (2022). The hepatotoxic potential of a mixture of toluene, styrene and ethanol: in silico toxicogenomic data-mining. in Arhiv za farmaciju
Savez farmaceutskih udruženja Srbije (SFUS)., 72(4 suplement), S567-S568.
https://hdl.handle.net/21.15107/rcub_farfar_4608

Umićević N, Baralić K, Đukić-Ćosić D, Antonijević-Miljaković E, Buha-Đorđević A, Ćurčić M, Bulat Z, Antonijević B. The hepatotoxic potential of a mixture of toluene, styrene and ethanol: in silico toxicogenomic data-mining. in Arhiv za farmaciju. 2022;72(4 suplement):S567-S568.
https://hdl.handle.net/21.15107/rcub_farfar_4608 .

Umićević, Nina, Baralić, Katarina, Đukić-Ćosić, Danijela, Antonijević-Miljaković, Evica, Buha-Đorđević, Aleksandra, Ćurčić, Marijana, Bulat, Zorica, Antonijević, Biljana, "The hepatotoxic potential of a mixture of toluene, styrene and ethanol: in silico toxicogenomic data-mining" in Arhiv za farmaciju, 72, no. 4 suplement (2022):S567-S568,
https://hdl.handle.net/21.15107/rcub_farfar_4608 .